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DEVELOPMENTAL PSYCHOLOGY
Week 2:
Foundations of Development
DEVELOPMENTAL PSYCHOLOGY
Influences on development
Genetic foundations
Environmental context
Genetic foundations of development Genetic code conveyed in deoxyribonucleic acid (DNA)
Gene: segment of DNA along length of chromosome
Allele: viable DNA (deoxyribonucleic acid) coding that occupies a given locus (position) on a chromosome.
DNALadder-like molecule, formed of chains of
nucleotide subunits. - deoxyribose sugar- a phosphate- a base. A set of three bases – a codon – acts as a
blueprint for the incorporation of a particular amino acid, the subunit of a protein molecule.
The two halves are joined together by the bases – a purine (adenine or guanine) or pyrimidine (cytosine or thymine) – forming pairs (the rungs of the ladder).
The bases form into two specific base pairs: adenine with thymine and guanine with cytosine.
National Human Genome Research Institute (NHGRI) http://www.genome.gov/12514471 by artist Darryl Leja
Genes
Length of a gene varies greatly
Gene concordance between human and chimpanzee is high (98% - 99%)
Only one base pair change is enough to influence human traits and capacities
Beginning of life
Gametes have 23 chromosomes
Combination of two gametes → zygote
Cell division (meiosis) – exchange of material causing variation
TwinsMonozygote- Identical- 100% concordance - 1 / 285
Dizygote- Non-identical, Fraternal
- 50% concordance
Patterns of genetic inheritance
An organism in which the two copies of the gene are identical — that is, have the same allele — is called homozygous for that gene.
An organism which has two different alleles of the gene is called heterozygous.
Class Activity
Dominance / recessive inheritance
Phenotypes: the expressed characteristics
Dominant characteristic: when only one allele affects the expression
Recessive characteristic: needs two alleles of the same type before it is expressed
Allele
Father/Mother
B b
B BB
(dom)
Bb(carrier)
b Bb(carrier)
bb
(rec)
Importance of genetic inheritance Understanding of how we express physical characteristicsUnderstanding of how some diseases/defects are
transmittede.g. PKU, an inability to metabolise amino acid
phenylalanine, causing CNS damage in first year of life, is a recessive code, that strikes 1 / 8k births. Both parents must have recessive allele for child to get PKU
Incomplete dominance
Cases where the pattern of inheritance in which both alleles are expressed, resulting in a combined trait or one that is intermediate between the two
For example, red flower and blue flower, after cross pollination, we get purple flowers
X-linked inheritance
In cases where the harmful allele is carried on the X chromosome, there is greater chance of the male expressing the disorder due to the fact that males only have one X chromosome
Usually is passed on by mother to sonHemophilia, muscular dystrophy, adrenoleukodystrophy, green colourblindness, fragile-x syndrome
Genetic imprinting
This refers to the chemical marking of a particular allele, such that the trait is always expressed
Genetic imprinting is a vaguely similar to monosomy but with different sequelae.
Genetic imprinting is the process by which certain mammalian genes are switched off during early embryo development, according to whether they were inherited from the father or mother.
Mutation
Sudden changes in the DNA which may affect one, two, or many genes. Such mutations could occur spontaneously or as by-product of harmful environmental agent (tetragenic)
Chromosomal abnormalities
Abnormalities within the chromosomes – give rise to developmental problems
Down syndrome: consequences include MR, memory and speech problems, slow motor development
Sex chromosome abnormalities: XYY syndrome, Klinefelter syndrome, Turner Syndrome
Class Discussion• Referring to ecological systems theory, explain why
parents of children with genetic disorders often experience increased stress. What factors, within and beyond the family, can help these parents support their children’s development?
Genetic counselling
Process by which to help ensure healthy babies
Maternal age, family background
Prenatal Diagnostic Methods
Method Description Timing
Amniocentesis Obtaining sample of uterine fluid by drawing fluid with syringe through abdominal wall
11-15weeks
Chronic Villus sampling
Removal of plug of tissue for analysis, entry via vagina
6-8weeks
Fetoscopy Visual analysis of the fetus, possible to obtain blood sample
5-18weeks
Ultrasound Beaming of high frequency sound waves at uterus
Caution <5x
Maternal blood analysis
Testing for elevated level of alpha-fetoprotein
By 2nd month
Preimplantation genetic diagnosis
Associated with in vitro fertilisation and duplication of zygote
Advantages of GC
Improving chances of healthy babies
Better prepared for what may come to pass
Prenatal diagnosis has led to advances in fetal medicine – administration of drugs, surgery, blood transfusions for fetus.
Environmental context for development (1)Family – having family support gives potential for social interaction
Direct influence: parents, grandparents
Indirect influence: third party effects such as emotional influences
Environmental context for development (2)Socioeconomic status – affects duration and timing of phases of family life cycle
- Early Vs late marriage- Number of children- Family interactions
Environmental context for development (3)Affluence and poverty
Collectivist Vs individualistic societies
Legal system and society support
Policies for the family
MCDYS- Promoting marriages- Supporting families- Nurturing and protecting the young
National family week – “eat with your family day”
Relationship between hereditary and environmentHereditary estimate: extent to which individual differences in complex traits in a specific population are due to genetic factors
Kinship studies compare characteristics of family members
Concordance rate: refers to the percentage of instances in which both twins show a trait when it is present in one twin
LifeSpan Development
Name the times in life that come to your mind
What is lifespan development?
When does lifespan development start?
Life Span Perspective
Leading dynamic systems approach- Lifelong - Multidimensional and multidirectional- Highly plastic- Affected by multiple interacting forces
27
Stages in development
Conception Embryonic developmentFetal developmentInfant ToddlerChildhoodAdolescenceYoung adulthoodMiddle adulthoodLate adulthood
Conception / Germinal stageConception occurs when a sperm joins with an egg
When fertilisation has occurred, the newly formed zygote will make its way down to the womb
By the end of a week, the blastocyst will implant in the uterine lining
Period of Zygote
First two weeks, within first trimester
Single cell zygote will multiply and form blastocyst
Embryonic period
3 – 8 weeks (first trimester)
Many major organs developed e.g. CNS, heart, muscles, ribs, backbone, digestive track, arms, legs, feet, toes, fingers
Period of the Fetus
This is the time of physical growth
Organs now get connected
New behaviours are learned
9 – 12 weeks – still within first trimester, lasts until birth of the infant
Teratogens
Any environmental agent that causes damage during the prenatal period
Effect is dependent on a few factors- Age- Dose- Heredity- Other negative influences
TeratogensSubstances that can produce birth defects
Especially harmful during embryonic period
E.g., Alcohol Use may cause Fetal Alcohol Syndrome (leading cause of preventable Mental Retardation)
-- Smoking during pregnancy restricts oxygen to the unborn: greater risks for several problems
Effect of teratogens (1)Prescriptive and OTC Drugs: for
relief from simple ailments – asprin, anti-depressants, caffeine – far reaching consequences
Illegal drugs: often consumed as a way of escaping reality – LT potential –ve effect
Tobacco: first, second and even third hand, has effect on reducing birth weight
Alcohol: fetal OH syndrome, effects
Radiation: possibility of physical defects, LBW, miscarriage, etc.
Environmental pollution: increased chance of life threatening diseases and future health problems
Infectious diseases: possible correlation with cataracts, deafness, heart, genital, urinary and intestinal abnormalities, and even MR
Effect of teratogens (2)
Effect of Maternal Factors
Maternal nutrition
Emotional stress
Rh factor incompatibility
Maternal age and previous birth experience
Group Discussion
• If you had to choose five environmental influences to publicize in a campaign aimed at promoting healthy prenatal development, which ones would you choose, and why?
Stages of Childbirth
Dilation and effacement of the cervix (12 – 14 hours 1st birth) to Transition
Delivery of the baby (pushing and birth)
Delivery of the placenta
Developmental scales
Apgar scales: measures physical condition- Five different scales: Appearance (colour), Pulse (heartrate), Grimace (reflex/irritability), Activity (muscle tone), Respiration (breathing)
- Score 0, 1, 2
New-born Baby’s CapacitiesNewborn Reflexes- Eye blink- Rooting- Sucking- Moro- Palmer grasp- Tonic neck- Stepping- Babinski
New-born states: Arousal
Infant States of Arousal
Regular sleep
Irregular sleepQuiet alertness
DrowsinessWaking actively and crying
New-born states: Senses
Touch – highly sensitive to pain
Taste – able to distinguish basic tastes
Smell – shows distinct preference
Hearing – preference for complex tones
Vision – least developed in the newborn