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SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-84 13 1984-98 48 1998-01 06 2001-11 43 2011-17 09 20 09
White 1975-87 16 1987-98 54 1998-01 -08 2001-11 49 2011-17 17 27 17
Black 1975-02 29 2002-09 62 2009-17 04 10 04
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-02 19 2002-07 48 2007-15 25 2015-17 -14 16 05
White 2000-02 06 2002-06 56 2006-14 34 2014-17 00 22 09
White NHef 2000-14 38 2014-17 01 25 10
Black 2000-12 42 2012-17 -05 15 -05
Black NHef 2000-09 50 2009-17 10 14 10
APIe 2000-07 09 2007-17 -19 -19 -19
AIANeg 2000-17 34 34 34
Hispanicf 2000-14 26 2014-17 -22 10 -10
US Cancer Mortalityc 1975-2017
All Races 1975-80 02 1980-87 20 1987-95 38 1995-07 19 2007-13 32 2013-17 06 20 06
White 1975-78 -12 1978-87 16 1987-96 39 1996-00 05 2000-13 28 2013-17 14 22 14
Black 1975-88 08 1988-95 32 1995-00 03 2000-13 25 2013-17 01 14 01
US Cancer Mortalityc 2000-2017
All Races 2000-04 27 2004-07 16 2007-13 31 2013-17 07 20 07
White 2000-08 24 2008-13 33 2013-17 11 23 11
White NHef 2000-08 23 2008-12 36 2012-17 13 23 13
Black 2000-13 25 2013-17 01 14 01
Black NHef 2000-13 26 2013-17 01 15 01
APIe 2000-17 -12 -12 -12
AIANeg 2000-17 18 18 18
Hispanicf 2000-17 14 14 14
Table 141
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Both Sexes by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-84 22 1984-11 39 2011-17 07 17 07
White 1975-87 18 1987-98 54 1998-01 -07 2001-11 50 2011-17 10 23 10
Black 1975-02 31 2002-09 66 2009-17 00 08 00
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-08 43 2008-15 21 2015-17 -13 13 04
White 2000-02 03 2002-06 63 2006-14 30 2014-17 -03 19 05
White NHef 2000-02 -10 2002-05 70 2005-14 33 2014-17 -01 21 07
Black 2000-09 50 2009-17 09 14 09
Black NHef 2000-09 49 2009-17 10 14 10
APIe 2000-17 -09 -09 -09
AIANeg 2000-17 38 38 38
Hispanicf 2000-10 35 2010-17 -02 06 -02
US Cancer Mortalityc 1975-2017
All Races 1975-85 15 1985-96 38 1996-99 03 1999-13 27 2013-17 06 17 06
White 1975-85 14 1985-95 39 1995-06 20 2006-12 34 2012-17 11 21 11
Black 1975-01 16 2001-12 30 2012-17 -02 12 -02
US Cancer Mortalityc 2000-2017
All Races 2000-13 27 2013-17 06 17 06
White 2000-07 23 2007-12 35 2012-17 11 21 11
White NHef 2000-07 22 2007-12 35 2012-17 10 21 10
Black 2000-12 29 2012-17 -01 12 -01
Black NHef 2000-12 30 2012-17 -02 12 -02
APIe 2000-03 05 2003-06 -33 2006-13 02 2013-17 -34 -14 -34
AIANeg 2000-17 23 23 23
Hispanicf 2000-17 13 13 13
Table 142
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Males by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-83 06 1983-96 42 1996-17 28 28 28
White 1975-85 08 1985-99 40 1999-02 -19 2002-17 39 39 39
Black 1975-17 28 28 28
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-14 32 2014-17 03 22 10
White 2000-17 33 33 33
White NHef 2000-17 31 31 31
Black 2000-13 39 2013-17 -16 14 -16
Black NHef 2000-13 38 2013-17 -18 13 -18
APIe 2000-17 -11 -11 -11
AIANeg 2000-17 26 26 26
Hispanicf 2000-17 23 23 23
US Cancer Mortalityc 1975-2017
All Races 1975-84 02 1984-95 31 1995-08 12 2008-13 33 2013-17 13 24 13
White 1975-87 06 1987-96 35 1996-01 -03 2001-17 23 23 23
Black 1975-17 15 15 15
US Cancer Mortalityc 2000-2017
All Races 2000-04 24 2004-08 07 2008-13 33 2013-17 13 24 13
White 2000-05 24 2005-08 07 2008-13 34 2013-17 17 26 17
White NHef 2000-17 22 22 22
Black 2000-17 17 17 17
Black NHef 2000-17 18 18 18
APIe 2000-17 -14 -14 -14
AIANeg 2000-17 08 08 08
Hispanicf 2000-17 12 12 12
Table 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 1271986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 1821989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 807 1255 417 661 1025 337 1189 1953 5832010 820 1255 441 677 1038 357 1192 1956 6032011 863 1328 456 725 1112 380 1175 1979 5352012 868 1349 449 740 1159 366 1223 2061 5802013 878 1345 468 754 1144 401 1195 1965 5922014 891 1352 483 770 1175 402 1163 1940 5762015 923 1413 498 789 1190 430 1247 2062 6292016 908 1365 505 785 1179 429 1239 1917 7152017 903 1369 499 798 1189 447 1183 2003 578
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-2017 587 909 321 479 741 263 851 1393 4331975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 -1986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 -1989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 806 1254 416 660 1024 337 1187 1950 5822010 818 1252 440 676 1036 356 1189 1951 6012011 860 1324 454 722 1108 379 1171 1972 5332012 865 1343 447 737 1154 365 1217 2051 5772013 874 1338 465 750 1138 399 1188 1953 5892014 886 1344 480 765 1167 400 1155 1927 5722015 914 1399 493 780 1176 425 1233 2038 6222016 892 1342 496 771 1158 420 1215 1879 7012017 866 1313 478 761 1134 427 1129 1911 552
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-84 22 1984-11 39 2011-17 07 17 07
White 1975-87 18 1987-98 54 1998-01 -07 2001-11 50 2011-17 10 23 10
Black 1975-02 31 2002-09 66 2009-17 00 08 00
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-08 43 2008-15 21 2015-17 -13 13 04
White 2000-02 03 2002-06 63 2006-14 30 2014-17 -03 19 05
White NHef 2000-02 -10 2002-05 70 2005-14 33 2014-17 -01 21 07
Black 2000-09 50 2009-17 09 14 09
Black NHef 2000-09 49 2009-17 10 14 10
APIe 2000-17 -09 -09 -09
AIANeg 2000-17 38 38 38
Hispanicf 2000-10 35 2010-17 -02 06 -02
US Cancer Mortalityc 1975-2017
All Races 1975-85 15 1985-96 38 1996-99 03 1999-13 27 2013-17 06 17 06
White 1975-85 14 1985-95 39 1995-06 20 2006-12 34 2012-17 11 21 11
Black 1975-01 16 2001-12 30 2012-17 -02 12 -02
US Cancer Mortalityc 2000-2017
All Races 2000-13 27 2013-17 06 17 06
White 2000-07 23 2007-12 35 2012-17 11 21 11
White NHef 2000-07 22 2007-12 35 2012-17 10 21 10
Black 2000-12 29 2012-17 -01 12 -01
Black NHef 2000-12 30 2012-17 -02 12 -02
APIe 2000-03 05 2003-06 -33 2006-13 02 2013-17 -34 -14 -34
AIANeg 2000-17 23 23 23
Hispanicf 2000-17 13 13 13
Table 142
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Males by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-83 06 1983-96 42 1996-17 28 28 28
White 1975-85 08 1985-99 40 1999-02 -19 2002-17 39 39 39
Black 1975-17 28 28 28
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-14 32 2014-17 03 22 10
White 2000-17 33 33 33
White NHef 2000-17 31 31 31
Black 2000-13 39 2013-17 -16 14 -16
Black NHef 2000-13 38 2013-17 -18 13 -18
APIe 2000-17 -11 -11 -11
AIANeg 2000-17 26 26 26
Hispanicf 2000-17 23 23 23
US Cancer Mortalityc 1975-2017
All Races 1975-84 02 1984-95 31 1995-08 12 2008-13 33 2013-17 13 24 13
White 1975-87 06 1987-96 35 1996-01 -03 2001-17 23 23 23
Black 1975-17 15 15 15
US Cancer Mortalityc 2000-2017
All Races 2000-04 24 2004-08 07 2008-13 33 2013-17 13 24 13
White 2000-05 24 2005-08 07 2008-13 34 2013-17 17 26 17
White NHef 2000-17 22 22 22
Black 2000-17 17 17 17
Black NHef 2000-17 18 18 18
APIe 2000-17 -14 -14 -14
AIANeg 2000-17 08 08 08
Hispanicf 2000-17 12 12 12
Table 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 1271986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 1821989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 807 1255 417 661 1025 337 1189 1953 5832010 820 1255 441 677 1038 357 1192 1956 6032011 863 1328 456 725 1112 380 1175 1979 5352012 868 1349 449 740 1159 366 1223 2061 5802013 878 1345 468 754 1144 401 1195 1965 5922014 891 1352 483 770 1175 402 1163 1940 5762015 923 1413 498 789 1190 430 1247 2062 6292016 908 1365 505 785 1179 429 1239 1917 7152017 903 1369 499 798 1189 447 1183 2003 578
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-2017 587 909 321 479 741 263 851 1393 4331975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 -1986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 -1989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 806 1254 416 660 1024 337 1187 1950 5822010 818 1252 440 676 1036 356 1189 1951 6012011 860 1324 454 722 1108 379 1171 1972 5332012 865 1343 447 737 1154 365 1217 2051 5772013 874 1338 465 750 1138 399 1188 1953 5892014 886 1344 480 765 1167 400 1155 1927 5722015 914 1399 493 780 1176 425 1233 2038 6222016 892 1342 496 771 1158 420 1215 1879 7012017 866 1313 478 761 1134 427 1129 1911 552
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding
SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska
Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series
JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd
Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17
SEER 9 Delay-Adjusted Incidencea 1975-2017
All Races 1975-83 06 1983-96 42 1996-17 28 28 28
White 1975-85 08 1985-99 40 1999-02 -19 2002-17 39 39 39
Black 1975-17 28 28 28
SEER 21 Delay-Adjusted Incidenceb 2000-2017
All Races 2000-14 32 2014-17 03 22 10
White 2000-17 33 33 33
White NHef 2000-17 31 31 31
Black 2000-13 39 2013-17 -16 14 -16
Black NHef 2000-13 38 2013-17 -18 13 -18
APIe 2000-17 -11 -11 -11
AIANeg 2000-17 26 26 26
Hispanicf 2000-17 23 23 23
US Cancer Mortalityc 1975-2017
All Races 1975-84 02 1984-95 31 1995-08 12 2008-13 33 2013-17 13 24 13
White 1975-87 06 1987-96 35 1996-01 -03 2001-17 23 23 23
Black 1975-17 15 15 15
US Cancer Mortalityc 2000-2017
All Races 2000-04 24 2004-08 07 2008-13 33 2013-17 13 24 13
White 2000-05 24 2005-08 07 2008-13 34 2013-17 17 26 17
White NHef 2000-17 22 22 22
Black 2000-17 17 17 17
Black NHef 2000-17 18 18 18
APIe 2000-17 -14 -14 -14
AIANeg 2000-17 08 08 08
Hispanicf 2000-17 12 12 12
Table 143
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program
1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints
Females by RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 1271986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 1821989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 807 1255 417 661 1025 337 1189 1953 5832010 820 1255 441 677 1038 357 1192 1956 6032011 863 1328 456 725 1112 380 1175 1979 5352012 868 1349 449 740 1159 366 1223 2061 5802013 878 1345 468 754 1144 401 1195 1965 5922014 891 1352 483 770 1175 402 1163 1940 5762015 923 1413 498 789 1190 430 1247 2062 6292016 908 1365 505 785 1179 429 1239 1917 7152017 903 1369 499 798 1189 447 1183 2003 578
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-2017 587 909 321 479 741 263 851 1393 4331975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 -1986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 -1989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 806 1254 416 660 1024 337 1187 1950 5822010 818 1252 440 676 1036 356 1189 1951 6012011 860 1324 454 722 1108 379 1171 1972 5332012 865 1343 447 737 1154 365 1217 2051 5772013 874 1338 465 750 1138 399 1188 1953 5892014 886 1344 480 765 1167 400 1155 1927 5722015 914 1399 493 780 1176 425 1233 2038 6222016 892 1342 496 771 1158 420 1215 1879 7012017 866 1313 478 761 1134 427 1129 1911 552
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review
a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 1271986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 1821989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 807 1255 417 661 1025 337 1189 1953 5832010 820 1255 441 677 1038 357 1192 1956 6032011 863 1328 456 725 1112 380 1175 1979 5352012 868 1349 449 740 1159 366 1223 2061 5802013 878 1345 468 754 1144 401 1195 1965 5922014 891 1352 483 770 1175 402 1163 1940 5762015 923 1413 498 789 1190 430 1247 2062 6292016 908 1365 505 785 1179 429 1239 1917 7152017 903 1369 499 798 1189 447 1183 2003 578
Table 144Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Delay-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-2017 587 909 321 479 741 263 851 1393 4331975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 -1986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 -1989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 806 1254 416 660 1024 337 1187 1950 5822010 818 1252 440 676 1036 356 1189 1951 6012011 860 1324 454 722 1108 379 1171 1972 5332012 865 1343 447 737 1154 365 1217 2051 5772013 874 1338 465 750 1138 399 1188 1953 5892014 886 1344 480 765 1167 400 1155 1927 5722015 914 1399 493 780 1176 425 1233 2038 6222016 892 1342 496 771 1158 420 1215 1879 7012017 866 1313 478 761 1134 427 1129 1911 552
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Diagnosis1975-2017 587 909 321 479 741 263 851 1393 4331975-1979 267 405 164 223 331 145 408 632 2291980 263 394 167 226 328 156 362 501 2471981 293 465 166 249 388 151 459 709 2531982 294 437 188 240 348 164 385 540 2631983 291 468 158 238 374 141 411 630 2331984 286 427 187 232 341 161 334 526 1911985 316 509 173 260 415 151 391 751 -1986 320 478 202 261 389 170 503 756 3201987 339 484 221 266 364 187 546 769 3731988 339 545 182 271 425 159 484 886 -1989 360 558 217 286 428 189 528 907 2601990 394 604 230 306 466 186 650 1061 3471991 433 668 258 353 555 212 595 924 3481992 400 609 239 319 483 194 563 842 3431993 451 716 248 370 591 207 619 1012 3091994 445 699 248 360 560 209 505 952 1861995 455 680 281 357 537 224 610 858 4041996 542 829 314 441 676 263 672 1096 3551997 537 805 317 439 656 261 747 1137 4521998 548 834 314 454 695 257 651 964 4061999 584 887 335 475 722 273 778 1232 4392000 563 851 323 469 705 273 700 1173 3522001 561 869 314 435 660 255 789 1379 3402002 576 876 325 464 705 259 740 1195 3892003 616 946 333 500 773 266 777 1252 3992004 646 1011 335 517 804 268 946 1589 4532005 686 1045 376 552 858 289 943 1498 4892006 720 1109 381 586 920 293 978 1527 5332007 746 1164 383 602 945 300 1011 1755 4502008 766 1177 413 639 973 346 1101 1922 4882009 806 1254 416 660 1024 337 1187 1950 5822010 818 1252 440 676 1036 356 1189 1951 6012011 860 1324 454 722 1108 379 1171 1972 5332012 865 1343 447 737 1154 365 1217 2051 5772013 874 1338 465 750 1138 399 1188 1953 5892014 886 1344 480 765 1167 400 1155 1927 5722015 914 1399 493 780 1176 425 1233 2038 6222016 892 1342 496 771 1158 420 1215 1879 7012017 866 1313 478 761 1134 427 1129 1911 552
Table 145Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted SEER Incidencea Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention
Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
Year of Death1975-2017 473 696 296 433 632 276 658 1028 3841975-1979 278 385 199 257 349 191 445 679 2681980 278 388 200 256 351 191 449 678 2781981 287 411 199 267 376 191 440 667 2731982 294 420 205 269 379 193 469 716 2931983 292 420 200 263 372 187 480 727 3001984 302 435 207 274 385 198 482 793 2651985 311 440 219 285 394 208 457 718 2741986 315 453 215 288 408 203 472 726 2901987 320 456 220 292 414 204 476 690 3231988 330 482 221 302 438 208 476 724 3031989 344 502 229 313 451 215 510 800 3091990 361 527 243 327 474 225 529 781 3591991 369 532 251 335 480 232 529 797 3481992 391 571 259 356 517 240 545 850 3321993 404 582 274 371 532 256 549 810 3591994 413 602 273 377 542 255 572 890 3531995 436 631 291 397 571 269 621 930 4111996 444 646 291 408 587 273 590 907 3681997 450 653 297 411 591 275 602 889 3921998 459 674 292 419 608 273 638 1013 3701999 452 650 295 415 595 273 595 876 3822000 464 680 294 422 615 271 608 954 3582001 472 694 298 433 637 273 625 912 4082002 488 718 303 449 653 284 633 996 3652003 502 739 312 458 673 285 665 1030 4032004 513 742 323 468 673 298 692 1067 4112005 527 778 321 484 709 299 697 1118 3792006 530 772 329 488 704 309 696 1092 3912007 537 791 326 498 723 309 701 1132 3812008 557 834 326 515 763 305 735 1192 3942009 578 858 343 534 786 321 776 1217 4332010 591 874 354 547 800 332 773 1228 4262011 613 905 364 568 834 339 811 1277 4542012 634 937 377 591 865 354 827 1326 4462013 647 955 385 604 880 364 839 1346 4552014 649 949 393 605 879 368 839 1306 4792015 660 966 399 621 896 381 836 1337 4532016 667 970 408 628 906 385 852 1301 5112017 665 970 406 629 908 387 842 1318 481
Table 146Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-adjusted US Deatha Rates by Year Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted
b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted
c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 90 138 48 81 124 44 107 177 54Under 65 46 72 21 41 64 19 61 100 2865 and over 393 587 239 359 533 219 428 713 230
All ages (WHO world std)c 70 108 36 63 96 33 88 146 42
Age-Specific Rates 2013-2017lt1 15 18 13 15 17 12 14 - -1-4 06 08 05 07 08 05 04 - -5-9 01 01 01 01 - - - - -10-14 01 02 - 01 02 - - - -15-19 02 01 02 02 02 02 - - -20-24 02 02 02 02 02 02 - - -25-29 03 04 02 03 04 02 04 05 -30-34 05 07 04 04 04 04 08 14 -35-39 10 12 07 07 07 07 14 20 0840-44 18 25 12 14 18 10 21 28 1545-49 42 64 21 37 55 19 38 56 2250-54 110 173 49 103 162 46 111 170 6055-59 244 397 98 224 362 91 316 520 14160-64 372 609 155 329 536 135 612 1064 24665-69 396 630 190 349 545 170 633 1136 25070-74 373 558 217 340 503 200 413 696 21375-79 421 599 282 395 565 260 337 510 22580-84 423 620 286 396 581 263 332 531 22085+ 344 494 265 316 456 241 280 374 241
US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 66 96 40 62 90 38 84 132 48Under 65 28 44 14 26 39 13 42 68 2065 and over 326 461 220 311 436 211 379 580 241
All ages (WHO world std)c 43 65 24 40 59 23 60 97 31
Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 01 01 01 01 02 01 - - -5-9 00 01 00 00 00 - - - -10-14 00 - 00 00 - 00 - - -15-19 00 01 00 00 01 00 - - -20-24 01 01 01 01 01 01 01 - -25-29 01 02 01 01 02 01 02 03 -30-34 03 04 02 02 03 02 05 07 0335-39 06 07 04 04 05 04 09 14 0440-44 11 14 08 09 11 07 14 19 0945-49 26 37 15 23 33 13 27 38 1850-54 68 103 34 65 98 32 84 125 4855-59 154 245 69 143 226 64 224 364 10360-64 237 380 105 213 338 96 406 704 16265-69 256 391 134 233 351 126 419 721 18470-74 280 399 179 266 374 171 342 535 20275-79 355 482 254 345 470 243 352 481 26780-84 417 569 310 403 549 296 404 583 30385+ 420 579 335 408 562 325 385 525 326
Table 147Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)
Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey
Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017
d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)
e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - - - - - - -1970-1973a - - - - - - - - -1975-1977b 34 18 63 34 20 58 18 00 561978-1980b 33 22 54 33 22 48 36 30 501981-1983b 37 29 52 40 30 55 28 21 471984-1986b 56 36 95 57 37 91 44 21 911987-1989b 49 32 80 57 34 94 27 16 491990-1992b 56 50 70 63 51 83 26 20 361993-1995b 55 53 60 52 49 57 40 28 731996-1998b 86 83 91 84 76 102 46 59 201999-2001b 113 109 121 103 96 117 76 68 952002-2004b 148 149 147 141 146 130 96 73 1582005-2009b 176 177 173 168 171 162 127 124 1362010-2016b 208f 208f 209f 199f 202f 190f 187f 183 197f
5-Year Period Survival (Percent)cd
2016 206 203 211 195 195 198 184 178 199
Stage Distribution () 2010-2016ce
All StagesNumber of cases 51112 37202 13910 35853 26237 9616 6689 4952 1737Percent 100 100 100 100 100 100 100 100 100Localized 44 44 44 44 45 43 42 41 44Regional 27 27 24 26 27 25 29 30 27Distant 18 18 19 18 17 19 19 20 18UnstagedUnknown 11 10 12 11 11 13 9 9 10
5-Year Relative Survival (Percent) 2010-2016c
Age at DiagnosisAges lt45 416 390 462 493 477 519 264 242 301g
Ages 45-54 213 197 275 205 189 267 173 151 236Ages 55-64 219 212 247 214 210 231 176 158 242Ages 65-74 185 179 198 167 163 174 171 172 169Ages 75+ 98 97 100 81 80 82 85 71 95Ages lt65 230 217 277 227 216 270 181 161 247Ages 65+ 149 149 147 131 133 126 148 151 140
StageeAll Stages 196 193 205 187 186 189 171 159 205Localized 342 338 351 325 324 329 300 281 349Regional 120 116 134 120 116 133 105 99 122Distant 25 21 35 27 22 37 23 20 34UnstagedUnknown 70 64 81 57 54 64 93 89 103
Table 148Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 137 149 178 214 234 247 277 268 277 290 312 329 363 383 391 392 421 448 446 484 470 465 490 491 525 5252-year 66 83 98 124 137 150 174 170 178 199 217 223 248 263 270 288 303 325 312 361 335 324 353 368 3933-year 48 61 73 87 95 109 125 131 143 154 160 176 205 207 212 234 240 258 243 279 263 248 273 2954-year 41 46 63 69 69 92 101 107 120 124 138 155 171 176 184 199 210 216 198 226 227 205 2325-year 34 38 53 56 57 82 82 94 101 117 120 141 156 147 168 171 185 187 170 194 203 1806-year 30 36 50 50 49 71 74 84 91 108 110 120 150 133 154 156 165 169 153 173 1867-year 28 31 48 46 44 67 67 70 83 100 99 114 133 127 141 146 146 156 145 1588-year 27 29 44 44 42 65 59 66 78 96 89 104 123 121 135 137 137 143 1319-year 25 29 42 43 41 60 57 56 75 94 85 101 117 116 124 130 130 13610-year 25 29 40 42 36 57 55 55 74 90 79 93 112 108 117 126 12011-year 25 27 40 40 32 56 55 48 69 87 78 87 109 103 116 12112-year 25 27 38 39 31 53 55 46 68 86 76 81 106 99 11613-year 23 25 38 38 31 51 55 45 66 84 75 76 102 9714-year 23 25 37 37 31 49 55 45 61 84 72 74 10015-year 22 25 37 37 30 41 51 45 59 83 68 7216-year 22 24 37 36 30 40 48 45 54 82 6617-year 21 24 37 35 29 40 46 44 53 8118-year 20 23 37 34 28 40 44 41 5319-year 20 22 37 33 28 40 44 4120-year 20 22 37 33 28 39 44
Table 149Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males and Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 113 128 148 202 219 247 268 254 287 285 307 322 353 375 400 394 413 455 455 492 469 465 485 495 526 5252-year 48 65 73 114 122 160 166 162 178 193 206 213 248 256 278 297 298 330 318 368 335 323 350 371 3933-year 32 49 52 81 90 113 121 121 138 156 153 180 201 199 217 238 242 261 245 290 266 244 268 2994-year 27 34 45 63 62 94 97 106 114 124 129 158 169 175 186 200 205 220 198 230 230 202 2275-year 20 28 35 52 50 80 80 89 101 114 111 145 158 144 170 170 182 190 174 199 204 1776-year 17 26 33 48 43 70 75 77 90 106 102 122 150 130 156 154 161 170 156 174 1887-year 14 22 33 43 37 66 69 62 83 101 93 113 134 123 141 145 140 159 146 1618-year 14 19 30 41 35 65 57 61 77 100 81 102 122 117 133 137 132 149 1299-year 13 19 30 39 34 60 56 53 75 99 76 97 114 113 122 129 127 14210-year 13 19 29 38 28 56 56 53 74 96 71 87 107 104 117 127 11911-year 13 18 29 37 23 53 56 44 69 93 71 79 105 98 116 12112-year 13 17 27 36 21 51 56 43 69 92 70 74 101 96 11613-year 11 14 27 35 21 50 56 43 68 88 68 70 98 9414-year 11 14 26 35 21 46 55 42 63 88 62 66 9515-year 10 14 26 35 21 40 52 42 63 88 56 6516-year 10 14 26 34 21 40 46 41 59 86 5517-year 10 14 26 34 21 40 43 40 58 8518-year 10 14 26 33 21 40 39 37 5719-year 10 14 26 32 21 40 39 3720-year 10 14 26 32 21 40 39
Table 1410Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Males
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables
1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
SurvivalTime
1-year 184 190 237 240 263 246 296 297 256 301 324 345 386 407 370 387 445 430 423 464 473 466 504 482 524 5242-year 100 117 145 143 165 129 189 187 179 212 245 247 247 280 251 265 320 314 295 340 335 328 363 357 3933-year 78 83 114 101 104 99 132 152 153 151 178 167 215 229 202 225 236 249 237 250 256 259 287 2834-year 66 68 99 81 83 87 110 108 133 123 159 149 177 181 178 196 223 207 197 213 219 214 2445-year 61 57 88 63 70 85 84 102 103 121 140 133 151 155 162 173 194 179 158 180 200 1926-year 54 53 84 56 60 73 73 99 92 111 127 118 149 143 148 159 178 169 146 171 1807-year 54 49 77 51 57 67 62 87 82 97 113 116 131 139 139 149 161 150 142 1478-year 52 47 70 51 54 64 62 75 80 90 108 108 126 131 139 137 151 130 1369-year 49 46 66 50 54 59 58 62 74 81 106 108 121 123 128 131 136 12210-year 49 45 62 50 51 59 52 59 74 79 95 105 121 121 116 126 12211-year 49 45 60 45 48 59 52 56 69 74 92 103 119 117 115 12212-year 45 45 60 44 48 57 52 53 64 74 90 98 117 106 11113-year 44 44 58 44 48 54 52 50 60 74 90 90 112 10414-year 44 44 58 42 48 54 52 50 54 74 90 90 11215-year 44 43 58 40 45 43 50 50 50 73 90 8616-year 43 43 58 40 45 39 50 50 43 73 8917-year 40 41 58 38 41 39 50 50 43 7218-year 38 39 57 36 37 39 50 50 4319-year 38 36 57 36 37 35 50 5020-year 38 36 56 34 37 35 50
Table 1411Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEERa Relative Survival (Percent)By Year of Diagnosis
All Races Females
Year of Diagnosis
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 103 078 Asian 0 001 001 001 179 143
10 000 000 001 103 079 Pacific 10 000 000 002 180 145
20 000 001 004 104 079 Islander 20 000 002 008 180 145
30 001 004 020 104 080 30 002 007 026 180 145
40 003 019 052 105 081 40 006 025 066 180 145
50 016 050 080 104 081 50 019 061 114 176 143
60 036 068 088 093 075 60 042 097 143 161 135
70 036 059 - 064 058 70 058 108 - 127 118
80 030 - - 037 040 80 058 - - 081 089
White 0 001 001 001 093 074 American 0 001 001 001 162 113
10 000 000 001 094 075 Indian 10 000 000 001 163 114
20 000 001 004 094 075 Alaska 20 000 001 007 163 115
30 001 003 018 094 076 Nativea 30 001 007 035 166 117
40 003 017 047 095 076 40 006 034 096 169 120
50 015 045 073 095 077 50 030 094 138 170 124
60 032 061 080 084 071 60 069 117 143 151 117
70 033 054 - 059 056 70 055 084 - 094 097
80 028 - - 034 038 80 039 - - 052 063
Black 0 000 001 001 110 087 Hispanicb 0 001 001 001 176 131
10 000 000 002 111 089 10 000 000 001 176 133
20 000 001 004 112 089 20 000 001 005 177 133
30 001 004 023 113 090 30 001 005 028 178 134
40 003 022 071 114 092 40 004 027 076 179 135
50 020 071 098 115 093 50 024 074 126 178 135
60 056 085 099 103 086 60 052 107 147 162 127
70 035 052 - 057 058 70 060 104 - 120 105
80 023 - - 030 038 80 054 - - 074 075
Table 1412
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Both Sexes 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 001 001 001 146 103 Asian 0 001 001 002 254 193
10 000 001 002 146 104 Pacific 10 000 001 003 255 195
20 000 001 006 147 104 Islander 20 001 003 012 256 195
30 001 006 030 148 106 30 002 012 045 256 196
40 005 030 081 150 107 40 010 043 108 256 196
50 026 079 121 150 108 50 034 100 173 250 193
60 057 102 128 133 099 60 068 145 202 224 180
70 052 082 - 088 074 70 083 146 - 170 152
80 042 - - 050 050 80 078 - - 107 115
White 0 001 001 001 131 097 American 0 001 001 001 228 137
10 000 000 001 131 098 Indian 10 000 000 002 229 139
20 000 001 005 132 098 Alaska 20 000 002 010 231 140
30 001 004 027 133 099 Nativea 30 002 010 050 235 143
40 004 027 072 135 101 40 008 050 141 242 149
50 024 070 109 135 102 50 044 140 202 246 155
60 050 091 115 119 093 60 106 174 208 222 144
70 047 075 - 080 070 70 080 120 - 136 113
80 039 - - 046 048 80 056 - - 079 075
Black 0 000 001 001 164 121 Hispanicb 0 001 001 001 236 166
10 000 001 002 167 123 10 000 000 001 237 167
20 000 002 006 168 124 20 000 001 007 238 168
30 002 006 036 171 127 30 001 007 043 240 170
40 004 035 116 173 129 40 006 043 118 243 172
50 032 117 159 177 132 50 038 115 185 243 172
60 094 141 158 161 123 60 081 156 204 216 160
70 058 080 - 083 077 70 084 138 - 153 127
80 034 - - 038 048 80 071 - - 090 088
Table 1413
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Males 2015-2017 By RaceEthnicity
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta
San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US
a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties
b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry
- Statistic could not be calculatedA percent of 000 represents a value that is below 0005
Risk of Being Risk of Being
Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying
Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer
All Races 0 000 001 001 062 054 Asian 0 000 001 001 115 102
10 000 000 001 062 055 Pacific 10 000 000 001 116 103
20 000 001 003 062 055 Islander 20 000 001 003 116 103
30 001 002 009 062 055 30 001 003 010 116 103
40 002 008 024 062 055 40 002 009 029 115 103
50 007 023 042 062 055 50 007 027 063 114 103
60 017 037 053 057 052 60 021 057 094 109 100
70 022 039 - 045 045 70 038 077 - 093 092
80 022 - - 028 033 80 045 - - 063 072
White 0 001 001 001 057 052 American 0 001 001 001 100 089
10 000 000 001 057 052 Indian 10 000 000 001 099 090
20 000 001 002 057 052 Alaska 20 000 001 004 100 090
30 001 002 008 057 052 Nativea 30 000 004 019 101 091
40 002 008 022 057 053 40 003 019 052 102 093
50 006 020 038 056 053 50 017 051 079 102 095
60 015 033 048 052 050 60 036 066 086 090 094
70 020 036 - 041 043 70 034 055 - 060 084
80 020 - - 026 031 80 027 - - 034 054
Black 0 000 000 001 061 057 Hispanicb 0 000 001 001 121 100
10 000 000 001 062 058 10 000 000 001 121 101
20 000 001 003 062 058 20 000 001 003 121 101
30 001 002 011 062 059 30 001 002 012 121 101
40 002 011 032 062 059 40 002 011 037 121 102
50 009 031 047 062 059 50 009 036 073 121 102
60 024 040 052 057 056 60 027 066 099 115 099
70 019 032 - 038 045 70 042 078 - 095 088
80 017 - - 025 033 80 043 - - 063 066
Table 1414
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Risk of Being Diagnosed With Cancer in 10 20 and 30 Years
Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and
Lifetime Risk of Dying from Cancer Given Alive at Current Age
Females 2015-2017 By RaceEthnicity
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute
- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval
a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts
c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017
d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017
e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry
f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties
g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)
SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb
Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d
Rate per 100000 persons AAPC () AAPC ()
Total Males Females Total Males Females Total Males Females RaceEthnicity
All Races 90 138 48 11 08 17 17 14 27
White 81 124 44 17 12 23 24 19 37White Hispanice 142 211 83 02 -05 08 - - -White Non-Hispanice 72 110 38 20 13 29 - - -
Black 107 177 54 11 09 10 07 04 28
AsianPacific Islander 129 199 72 -23 -21 -30 - - -
Amer IndAlaska Natf 149 216 90 29 33 21 - - -
Hispanice 137 203 81 05 02 21 - - -
US Mortalityg Rate 2013-2017 Trend 2008-2017h
Rate per 100000 persons AAPC ()
Total Males Females Total Males FemalesRaceEthnicity
All Races 66 96 40 20 17 24
White 62 90 38 23 21 26White Hispanice 99 141 64 15 09 13White Non-Hispanice 58 84 35 23 21 22
Black 84 132 48 14 12 17
AsianPacific Islander 91 135 56 -12 -14 -14
Amer IndAlaska NatTotal US 75 104 50 12 16 05PRCDA Counties 106 148 71 18 23 08Non-PRCDA Counties 40 57 24 10 12 06
Hispanice 93 133 60 14 13 12
Table 1415Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa
By RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta
The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Incidence Ratesa 2013-2017
California 987 1478 553 914 1351 517 1103 1764 562Greater Bay Area 1058 1607 570 918 1355 513 1383 2297 631San Francisco-Oakland 1065 1641 559 913 1366 493 1332 2288 568San Jose-Monterey 1044 1545 591 928 1335 548 1737 2394 1088
Los Angeles 943 1385 569 889 1276 549 969 1492 571Greater California 982 1477 539 924 1383 506 1093 1747 515
Connecticut 788 1245 396 739 1179 359 997 1581 559Detroit 832 1279 457 714 1097 384 1236 2025 666Georgia 818 1259 447 776 1173 425 867 1408 460Atlanta 864 1337 482 697 1050 392 1021 1689 549Rural Georgia 743 1150 412 925 1338 - - - -Greater Georgia 804 1234 434 807 1223 438 767 1230 401
Hawaii 1121 1678 623 864 1249 442 - - -Idaho 733 1090 402 697 1041 374 - - -Iowa 677 992 393 633 923 373 1872 2942 764Kentucky 851 1297 466 833 1266 455 1063 1690 554Louisiana 997 1626 450 854 1342 418 1276 2261 494Massachusetts 803 1295 393 728 1172 357 1077 1762 527New Jersey 780 1227 409 746 1162 395 895 1492 457New Mexico 1041 1587 544 993 1520 511 857 1123 -New York 909 1421 481 793 1227 424 1105 1854 569Seattle-Puget Sound 981 1474 536 838 1254 456 1772 2540 948Utah 619 890 372 575 830 342 - - -
SEER 9 Areasb 887 1349 483 766 1156 415 1187 1946 610SEER 13 Areasb 908 1367 509 799 1189 449 1140 1842 603SEER 18 Areasb 905 1378 493 829 1247 454 1062 1747 527SEER 21 Areasb 897 1375 483 813 1235 441 1074 1774 538
Table 1416Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Incidence Ratesa
By Registry Race and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)
b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts
- Statistic not shown Rate based on less than 16 cases for the time interval
All Races Whites Blacks Total Males Females Total Males Females Total Males Females
SEER Death Ratesa 2013-2017
California 776 1113 487 730 1030 466 864 1301 511Greater Bay Area 748 1112 437 650 946 390 1018 1641 511San Francisco-Oakland 752 1145 422 647 973 364 1060 1758 510San Jose-Monterey 740 1047 467 655 898 434 746 949 -
Los Angeles 815 1150 542 781 1068 538 803 1124 559Greater California 768 1098 480 734 1042 460 854 1309 463
Connecticut 566 837 342 540 806 318 801 1141 550Detroit 630 912 397 560 795 357 868 1355 525Georgia 641 939 396 612 878 383 698 1094 411Atlanta 635 925 407 524 741 350 757 1184 457Rural Georgia 558 678 444 652 741 - - - -Greater Georgia 651 958 393 645 935 392 672 1056 388
Hawaii 836 1238 481 664 979 317 - - -Idaho 584 815 372 566 797 354 - - -Iowa 537 766 337 510 726 322 1341 1991 -Kentucky 668 967 417 656 946 412 820 1218 497Louisiana 882 1354 482 755 1138 424 1179 1880 627Massachusetts 652 1006 366 623 951 357 794 1294 400New Jersey 584 869 355 572 850 345 687 1082 403New Mexico 801 1165 476 790 1162 453 671 - -New York 605 917 353 565 843 337 692 1146 380Seattle-Puget Sound 680 986 409 609 877 369 1083 1502 642Utah 481 659 320 447 609 299 - - -
SEER 9 Areasb 650 951 394 577 835 351 865 1358 499SEER 13 Areasb 691 998 430 622 884 393 842 1283 509SEER 18 Areasb 703 1021 432 654 938 407 842 1304 487SEER 21 Areasb 681 999 413 635 921 390 802 1266 455
Total US 658 963 398 618 895 378 843 1324 477
Table 1417Cancer of the Liver And Intrahepatic Bile Duct (Invasive)
Age-Adjusted SEER Death Ratesa
By Registry Race and Sex
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 658 002
High Five StatesDC 929 053 01(0106) 4113c
Louisiana 882 018 02(0104) 3398c
Hawaii 836 031 03(0108) 2698c
Texas 821 008 04(0206) 2467c
New Mexico 801 025 05(0209) 2171c
Low Five StatesMaine 512 024 47(3551) -2226c
Utah 481 020 48(4251) -2690c
North Dakota 464 033 49(3851) -2955c
Vermont 456 033 50(4051) -3076c
Nebraska 451 020 51(4651) -3155c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 708 015 09(0717) 750 Montana 544 029 43(2450) -1735c
Alaska 663 047 17(0545) 063 Nebraska 451 020 51(4651) -3155c
Arizona 642 012 21(1332) -255 Nevada 628 020 27(1239) -460Arkansas 680 019 14(0827) 326 New Hampshire 533 025 46(3050) -1902c
California 776 006 07(0408) 1784c New Jersey 584 010 37(2942) -1134Colorado 549 014 41(3547) -1661c New Mexico 801 025 05(0209) 2171c
Connecticut 566 016 38(2946) -1402 New York 605 007 31(2537) -810Delaware 692 034 11(0534) 504 North Carolina 659 011 18(1127) 004DC 929 053 01(0106) 4113c North Dakota 464 033 49(3851) -2955c
Florida 627 007 28(2032) -482 Ohio 606 009 30(2438) -803Georgia 641 011 23(1331) -260 Oklahoma 701 018 10(0820) 642Hawaii 836 031 03(0108) 2698c Oregon 673 016 15(0827) 219Idaho 584 025 36(1747) -1129 Pennsylvania 633 009 26(1732) -393Illinois 637 009 24(1631) -328 Rhode Island 719 033 08(0427) 928Indiana 593 012 34(2542) -999 South Carolina 642 015 22(1234) -256Iowa 537 017 45(3549) -1839c South Dakota 546 033 42(2151) -1711c
Kansas 585 019 35(2245) -1116 Tennessee 691 013 12(0820) 499Kentucky 668 016 16(0929) 147 Texas 821 008 04(0206) 2467c
Louisiana 882 018 02(0104) 3398c Utah 481 020 48(4251) -2690c
Maine 512 024 47(3551) -2226c Vermont 456 033 50(4051) -3076c
Maryland 656 014 19(1129) -037 Virginia 600 011 33(2440) -892Massachusetts 652 013 20(1130) -097 Washington 681 013 13(0822) 348Michigan 604 010 32(2439) -821 West Virginia 633 023 25(1039) -380Minnesota 539 013 44(3648) -1812c Wisconsin 552 013 40(3447) -1612c
Mississippi 784 021 06(0309) 1908c Wyoming 559 040 39(1351) -1512c
Missouri 622 013 29(1637) -546
Table 1418Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males and Females
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 963 003
High Five StatesDC 1373 097 01(0108) 4251c
Louisiana 1354 034 02(0103) 4054c
Hawaii 1238 055 03(0109) 2856c
Texas 1199 014 04(0207) 2454c
Mississippi 1168 039 05(0210) 2128c
Low Five StatesMontana 745 048 47(2851) -2263c
Utah 659 034 48(4551) -3156c
Nebraska 651 036 49(4451) -3237c
Vermont 637 058 50(4051) -3382c
North Dakota 621 058 51(4151) -3550c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 1071 029 09(0517) 1120 Montana 745 048 47(2851) -2263c
Alaska 912 078 26(0548) -528 Nebraska 651 036 49(4451) -3237c
Arizona 914 022 25(1736) -505 Nevada 868 034 34(1944) -993Arkansas 1006 035 14(0728) 443 New Hampshire 846 047 37(1547) -1220California 1113 011 07(0510) 1556c New Jersey 869 019 33(2341) -982Colorado 765 024 45(3748) -2052c New Mexico 1165 045 06(0212) 2093c
Connecticut 837 029 38(2346) -1305 New York 917 013 24(1933) -474Delaware 1017 061 12(0437) 559 North Carolina 995 019 15(0923) 331DC 1373 097 01(0108) 4251c North Dakota 621 058 51(4151) -3550c
Florida 925 012 23(1831) -391 Ohio 873 016 31(2440) -940Georgia 939 020 22(1432) -255 Oklahoma 1025 031 11(0723) 645Hawaii 1238 055 03(0109) 2856c Oregon 965 028 20(0931) 017Idaho 815 043 40(2148) -1543c Pennsylvania 942 016 21(1530) -217Illinois 892 017 29(2038) -736 Rhode Island 1089 061 08(0327) 1310Indiana 870 022 32(2242) -969 South Carolina 986 027 17(0928) 238Iowa 766 029 44(3549) -2047c South Dakota 806 059 41(1650) -1635c
Kansas 832 033 39(2347) -1357 Tennessee 1040 024 10(0719) 801Kentucky 967 029 19(1032) 040 Texas 1199 014 04(0207) 2454c
Louisiana 1354 034 02(0103) 4054c Utah 659 034 48(4551) -3156c
Maine 764 043 46(2950) -2065c Vermont 637 058 50(4051) -3382c
Maryland 993 025 16(0826) 313 Virginia 886 020 30(2040) -797Massachusetts 1006 024 13(0823) 450 Washington 976 023 18(1028) 129Michigan 850 017 35(2742) -1173 West Virginia 904 040 28(1142) -610Minnesota 778 023 43(3648) -1925c Wisconsin 795 022 42(3447) -1742c
Mississippi 1168 039 05(0210) 2128c Wyoming 850 071 36(0950) -1178Missouri 909 023 27(1638) -564
Table 1419Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Males
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)
b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval
State Rate SE Rank(CI)d PD TOTAL US 398 002
High Five StatesDC 558 056 01(0117) 4009c
Texas 491 008 02(0108) 2320c
California 487 007 03(0108) 2226c
Louisiana 482 019 04(0111) 2103c
Hawaii 481 032 05(0123) 2067c
Low Five StatesMaine 297 024 47(2751) -2555c
Vermont 291 037 48(1651) -2693c
Wyoming 283 040 49(1751) -2885c
Nebraska 278 022 50(3851) -3018c
New Hampshire 261 025 51(4051) -3438c
State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD
Alabama 410 016 15(0633) 285 Montana 350 032 39(0750) -1224Alaska 406 053 16(0150) 195 Nebraska 278 022 50(3851) -3018c
Arizona 399 013 19(0836) 014 Nevada 401 022 18(0543) 074Arkansas 405 021 17(0641) 166 New Hampshire 261 025 51(4051) -3438c
California 487 007 03(0108) 2226c New Jersey 355 011 36(2245) -1098Colorado 353 015 38(1647) -1147 New Mexico 476 027 06(0119) 1942c
Connecticut 342 017 41(1948) -1412 New York 353 007 37(2644) -1145Delaware 417 035 12(0146) 460 North Carolina 383 011 24(1238) -386DC 558 056 01(0117) 4009c North Dakota 313 036 45(1151) -2146c
Florida 369 007 31(2040) -742 Ohio 380 010 25(1338) -473Georgia 396 012 20(0934) -054 Oklahoma 412 018 13(0634) 353Hawaii 481 032 05(0123) 2067c Oregon 412 018 14(0635) 332Idaho 372 028 30(0748) -653 Pennsylvania 374 009 28(1640) -604Illinois 424 010 09(0621) 644 Rhode Island 424 035 08(0145) 647Indiana 358 013 34(1745) -1015 South Carolina 357 015 35(1646) -1049Iowa 337 018 42(2149) -1548c South Dakota 301 033 46(1551) -2439c
Kansas 373 021 29(0946) -645 Tennessee 395 014 21(0836) -079Kentucky 417 017 11(0632) 467 Texas 491 008 02(0108) 2320c
Louisiana 482 019 04(0111) 2103c Utah 320 022 44(2151) -1967c
Maine 297 024 47(2751) -2555c Vermont 291 037 48(1651) -2693c
Maryland 378 014 26(1142) -502 Virginia 359 012 33(2045) -997Massachusetts 366 013 32(1544) -816 Washington 421 014 10(0626) 560Michigan 392 011 22(0934) -153 West Virginia 391 024 23(0645) -184Minnesota 331 014 43(2749) -1693c Wisconsin 344 014 40(2247) -1367Mississippi 469 022 07(0117) 1780c Wyoming 283 040 49(1751) -2885c
Missouri 377 014 27(1142) -527
Table 1420Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017
Females
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years
b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997
Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available
Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee
Race Sex All Races Both Sexes 59658 16682 6951 2563 1124 86978 2972 89950
Males 42348 11786 4810 1574 690 61209 836 62044Females 17310 4896 2141 989 433 25769 2137 27905
White Both Sexes 44649 12441 5179 1867 863 65001 + +Males 31790 8787 3654 1103 548 45882 + +Females 12860 3654 1525 764 315 19119 + +
Black Both Sexes 8690 1858 571 147 67 11334 + +Males 6211 1311 293 84 18 7917 + +Females 2478 547 278 63 50 3416 + +
Asian Both Sexes 4884 2010 1025 455 126 8501 + +Pacific Males 3325 1418 732 326 94 5895 + +Islander Females 1560 592 293 129 32 2606 + +
Hispanic Both Sexes 8666 2428 927 314 188 12523 + +Males 6061 1655 679 167 136 8699 + +Females 2605 773 248 147 52 3825 + +
Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages
Race Sex All Races Both Sexes 00268 00031 00035 00021 00021 00064 00323 01052 00930 00647 00213
Males 00383 00032 00037 00024 00023 00083 00487 01685 01354 00970 00315Females 00157 00030 00032 00018 00019 00046 00165 00478 00575 00446 00123
White Both Sexes 00257 00033 00039 00023 00019 00057 00299 00934 00829 00576 00193Males 00366 00032 00042 00025 00021 00074 00453 01482 01198 00861 00282Females 00150 00034 00035 00020 00018 00040 00148 00427 00514 00396 00113
Black Both Sexes 00249 00013 00013 00009 00026 00056 00306 01570 01028 00507 00242Males 00362 00017 00013 00014 00027 00063 00410 02689 01651 00808 00385Females 00144 00008 00013 00005 00026 00051 00215 00677 00593 00356 00134
Asian Both Sexes 00408 00039 00042 00019 00027 00139 00592 01541 02310 02139 00426Pacific Males 00590 00046 00044 00020 00034 00204 00986 02580 03396 03139 00653Islander Females 00240 00032 00040 00018 00021 00082 00252 00704 01442 01487 00244
Hispanic Both Sexes 00215 00037 00037 00019 00013 00068 00480 01359 01578 00942 00303Males 00296 00041 00042 00020 00014 00092 00752 02142 02306 01261 00449Females 00133 00032 00033 00018 00011 00044 00212 00664 01018 00744 00178
Table 1421Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis
Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding
a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives
Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma arising from liver parenchyma are referred to as hepatocellular carcinomae Other carcinoma include histologies 8010 8012-8013 8020-8022 8031 8035 8041-8042 8046 8050 8124 8142 8154 8161-8162
8180 8190 8211 8240 8246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 85508574 8576
f Other specific carcinoma include histologies 8012-8013 8035 8041-8042 8124 8142 8154 8161-8162 8180 8190 8211 82408246 8249 8255 8290 8310 8323 8337 8440 8450 8453 8470-8471 8500 8503 8510 8521 8550 8574 8576
g Sarcoma includes histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 8920 8935-89368940 8963 8990 9040-9041 9044 9120 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
h Other sarcomas include histologies 8800-8806 8810 8815 8830 8850 8852 8854 8890-8891 8894-8896 8900 8910 89208935-8936 8940 8963 8990 9040-9041 9044 9124 9130 9133 9150 9180 9220 9260 9364 9473 9500 9540 9560 9581
- Statistic not shown due to fewer than 16 cases during the time period
AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc
Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent
Carcinoma (8010-8576) 34621 976 24847 975 4650 978 4527 978 288 963 5883 967Hepatocellular carcinomad 24131 680 16573 651 3608 759 3480 752 233 779 4285 704(8170-8175)
Cholangiocarcinoma 9215 260 7362 289 856 180 893 193 46 154 1405 231(8032-80338070-80718140-8141816082608480-848184908560)
Other carcinomae 1260 36 904 35 186 39 147 32 - - 191 31Other specific carcinomaf 900 25 655 26 117 25 113 24 - - 132 22Unspecified Carcinoma NOS 360 10 249 10 69 15 34 07 - - 59 10(80108020-8022803180468050)
Hepatoblastoma (8970) 304 09 219 09 38 08 35 08 - - 92 15
Sarcomag 297 08 224 09 29 06 40 09 - - 45 07Hemangiosarcoma (9120) 141 04 108 04 - - 21 05 - - 19 03Other sarcomash 156 04 116 05 18 04 19 04 - - 26 04
Other specific types 55 02 38 01 - - - - - - - -(872089808991906190649070-907190809100)
Unspecified (8000-8004) 195 05 143 06 25 05 20 04 - - 49 08
Totald 35481 1000 25477 1000 4754 1000 4629 1000 299 1000 6086 1000
Table 1422
Cancer of the Liver and Intrahepatic Bile Duct (Invasive)
Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Both Sexes by Race
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
0
5
10
15
20
25
1975 1985 1995 2005 20170
5
10
15
20
25
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 20170
1
2
3
4
5
6
7
8
1975 1985 1995 2005 2017
Delay-Adj IncidenceDelay-Adj Incidence
Observed IncidenceObserved Incidence
SEER Observed Incidence and Delay Adjusted Incidence RatesCancer of the Liver and Intrahepatic Bile Duct by Race and Sex
a
Figure 141
Source SEER 9 areas Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)
a
White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000
Year of Diagnosis Year of Diagnosis Year of Diagnosis Year of Diagnosis
SEER Incidence APCsDelay Adj 2011-17 = 10Observed 2012-17 = -03
SEER Incidence APCsDelay Adj 2009-17 = 00Observed 2009-17 = -04
SEER Incidence APCsDelay Adj 2002-17 = 39Observed 2002-17 = 37
SEER Incidence APCsDelay Adj 1975-17 = 28Observed 1975-17 = 28
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017
0
5
10
15
20
1975 1985 1995 2005 20170
5
10
15
20
1975 1985 1995 2005 2017
White
Black
API
AIAN
Hispanic
SEER Incidence and US Death RatesCancer of the Liver and Intrahepatic Bile Duct Both Sexes
Figure 142
Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry
Incidence MortalityRate per 100000 Rate per 100000
Year of Diagnosis Year of Death
a
d
a
b
c
c
b
d
SEE
R C
ancer Statistics Review
1975-2017N
ational Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
Figure 143
Cancer of the Liver and Intrahepatic Bile Duct5-Year SEER Conditional Relative Survival and
95 Confidence Intervals
Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error
0
20
40
60
80
100Percent Surviving Next 5 Years
Stage at Diagnosis
Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years
2000-2015 by stage at diagnosis
Survival Time Since Diagnosis
Localized Regional Distant Unstaged
0 year (at diagnosis) 1 year 3 years
SEER Cancer Statistics Review 1975-2017 National Cancer Institute
