SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-80 -05 1980-87 40 1987-94 -02 1994-99 18 1999-04 -23 2004-17 04 04 04

White 1975-80 -05 1980-87 41 1987-94 -02 1994-99 20 1999-04 -25 2004-17 03 03 03

Black 1975-78 -24 1978-88 34 1988-17 03 03 03

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-04 -21 2004-17 04 04 04

White 2000-04 -23 2004-17 03 03 03

White NHef 2000-04 -23 2004-17 04 04 04

Black 2000-17 08 08 08

Black NHef 2000-17 08 08 08

APIe 2000-06 01 2006-17 17 17 17

AIANeg 2000-17 08 08 08

Hispanicf 2000-17 06 06 06

US Cancer Mortalityc 1975-2017

All Races 1975-90 04 1990-95 -18 1995-98 -33 1998-11 -19 2011-17 -13 -15 -13

White 1975-90 03 1990-95 -20 1995-98 -35 1998-11 -19 2011-17 -13 -15 -13

Black 1975-93 14 1993-17 -15 -15 -15

US Cancer Mortalityc 2000-2017

All Races 2000-09 -20 2009-17 -14 -15 -14

White 2000-08 -21 2008-17 -15 -15 -15

White NHef 2000-08 -20 2008-14 -16 2014-17 -09 -14 -11

Black 2000-17 -15 -15 -15

Black NHef 2000-17 -14 -14 -14

APIe 2000-17 -07 -07 -07

AIANeg 2000-04 75 2004-13 -37 2013-17 52 01 52

Hispanicf 2000-17 -11 -11 -11

Table 41

Cancer of the Female Breast (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

All Ages by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-80 -13 1980-87 27 1987-94 -08 1994-17 03 03 03

White 1975-80 -11 1980-87 27 1987-94 -09 1994-17 03 03 03

Black 1975-90 13 1990-17 -01 -01 -01

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 04 04 04

White 2000-17 04 04 04

White NHef 2000-17 05 05 05

Black 2000-17 05 05 05

Black NHef 2000-17 06 06 06

APIe 2000-17 13 13 13

AIANeg 2000-17 -01 -01 -01

Hispanicf 2000-06 -10 2006-17 13 13 13

US Cancer Mortalityc 1975-2017

All Races 1975-90 -04 1990-07 -32 2007-17 -13 -13 -13

White 1975-90 -06 1990-05 -36 2005-17 -14 -14 -14

Black 1975-89 16 1989-17 -22 -22 -22

US Cancer Mortalityc 2000-2017

All Races 2000-08 -29 2008-17 -12 -12 -12

White 2000-07 -31 2007-17 -12 -12 -12

White NHef 2000-07 -30 2007-17 -13 -13 -13

Black 2000-17 -22 -22 -22

Black NHef 2000-17 -21 -21 -21

APIe 2000-08 -52 2008-17 13 13 13

AIANeg 2000-17 -15 -15 -15

Hispanicf 2000-17 -15 -15 -15

Table 42

Cancer of the Female Breast (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Ages lt50 by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-82 09 1982-87 53 1987-94 -01 1994-99 23 1999-04 -30 2004-17 03 03 03

White 1975-82 09 1982-87 55 1987-93 -03 1993-00 17 2000-04 -39 2004-17 03 03 03

Black 1975-92 26 1992-17 04 04 04

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-04 -28 2004-17 03 03 03

White 2000-04 -30 2004-17 02 02 02

White NHef 2000-04 -31 2004-17 03 03 03

Black 2000-17 09 09 09

Black NHef 2000-17 09 09 09

APIe 2000-06 -02 2006-17 18 18 18

AIANeg 2000-17 10 10 10

Hispanicf 2000-17 05 05 05

US Cancer Mortalityc 1975-2017

All Races 1975-90 06 1990-08 -20 2008-17 -15 -15 -15

White 1975-89 05 1989-95 -14 1995-98 -34 1998-17 -17 -17 -17

Black 1975-93 16 1993-17 -13 -13 -13

US Cancer Mortalityc 2000-2017

All Races 2000-13 -18 2013-17 -11 -15 -11

White 2000-09 -20 2009-17 -15 -15 -15

White NHef 2000-13 -18 2013-17 -10 -15 -10

Black 2000-17 -14 -14 -14

Black NHef 2000-17 -13 -13 -13

APIe 2000-17 -05 -05 -05

AIANeg 2000-04 91 2004-13 -40 2013-17 57 02 57

Hispanicf 2000-17 -10 -10 -10

Table 43

Cancer of the Female Breast (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Ages 50+ by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Observed Incidencea 1975-2017

All Races 1975-81 -31 1981-87 252 1987-94 38 1994-98 97 1998-09 11 2009-17 -12 -10 -12

White 1975-81 -29 1981-87 254 1987-95 39 1995-98 111 1998-09 09 2009-17 -17 -14 -17

Black 1975-83 62 1983-88 232 1988-93 37 1993-98 108 1998-14 13 2014-17 -39 -04 -26

SEER 21 Observed Incidenceb 2000-2017

All Races 2000-05 01 2005-08 45 2008-17 -11 -11 -11

White 2000-05 -01 2005-08 46 2008-17 -18 -18 -18

White NHef 2000-05 -02 2005-08 50 2008-17 -18 -18 -18

Black 2000-12 30 2012-17 -11 07 -11

Black NHef 2000-13 29 2013-17 -20 07 -20

APIe 2000-05 04 2005-08 63 2008-17 08 08 08

AIANeg 2000-17 00 00 00

Hispanicf 2000-07 31 2007-17 09 09 09

Table 44

Cancer of the Female Breast (In Situ)

Trends in SEER Incidenceab Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

All Ages by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 6915 112 12678 7062 111 13032 6864 176 119531975-1979 5665 096 10213 5819 094 10481 4971 144 87941980 5691 090 10224 5855 093 10514 5059 - 89481981 5933 100 10635 6123 093 10989 5433 - 94201982 5924 098 10650 6107 094 10994 5393 - 93581983 6188 104 11111 6370 113 11446 5899 - 103641984 6448 093 11599 6658 094 11989 5839 - 102411985 6914 096 12430 7098 098 12779 6421 - 111891986 7047 095 12686 7229 096 13040 6644 - 115331987 7479 096 13451 7780 098 14025 6313 - 109531988 7313 124 13139 7560 116 13627 6919 276 119011989 7079 112 12730 7341 107 13245 6075 - 105231990 7321 113 13191 7535 115 13627 6875 - 118981991 7411 112 13388 7664 117 13891 6748 - 117511992 7307 104 13213 7474 102 13574 7180 - 124391993 7135 108 12924 7315 104 13310 6905 - 119861994 7211 113 13101 7429 108 13572 7088 - 122961995 7291 095 13276 7514 091 13766 7181 - 124091996 7342 131 13383 7539 132 13825 7191 - 124731997 7565 110 13811 7761 106 14267 7310 - 126331998 7737 107 14148 7961 112 14651 7248 - 126381999 7722 096 14158 7961 095 14714 7321 - 126742000 7445 115 13666 7729 113 14307 6930 286 119412001 7570 124 13894 7835 124 14509 6736 166 116702002 7378 115 13594 7595 114 14126 7178 195 124542003 6901 133 12713 7090 134 13190 7139 185 123922004 6953 121 12837 7085 122 13211 7179 169 124782005 6848 104 12676 7026 114 13142 6836 - 119252006 6831 113 12651 6975 115 13064 7226 164 125782007 6924 108 12846 7062 111 13263 7201 167 124972008 6921 116 12863 7002 118 13169 7391 143 128802009 7048 114 13104 7152 119 13461 7445 - 129852010 6837 121 12726 6954 110 13117 7108 293 123212011 7008 133 13058 7093 126 13398 7408 273 128792012 6994 132 13035 7035 133 13293 7695 214 133842013 7016 118 13120 7051 122 13369 7428 189 129612014 7015 116 13155 7056 111 13426 7304 185 128182015 7021 118 13182 7061 117 13461 7418 159 129922016 6962 121 13068 7008 105 13373 7446 300 129492017 7004 132 13161 7077 134 13514 6968 201 12192

Table 45Cancer of the Breast (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 1522 031 2694 1505 030 2677 1924 054 32721975-1979 1803 035 3174 1817 034 3200 1798 053 31161980 1804 030 3168 1815 030 3193 1837 042 31681981 1820 032 3192 1828 031 3212 1895 046 32551982 1839 033 3219 1842 032 3231 1968 056 33751983 1833 031 3207 1836 029 3220 1957 050 33531984 1879 029 3290 1876 028 3290 2097 047 35941985 1884 034 3298 1888 034 3311 2035 043 34851986 1876 028 3287 1876 027 3293 2069 042 35441987 1866 034 3266 1857 034 3257 2153 047 36731988 1898 033 3320 1885 028 3309 2235 088 37781989 1900 033 3323 1895 033 3323 2156 045 36611990 1893 028 3314 1879 026 3302 2249 052 38001991 1866 028 3269 1846 027 3245 2262 044 38281992 1807 031 3164 1789 030 3143 2188 045 37091993 1798 036 3139 1774 034 3109 2262 066 38041994 1767 035 3092 1740 034 3056 2244 060 37741995 1744 035 3055 1711 032 3009 2270 077 38181996 1683 034 2949 1652 031 2905 2209 072 37131997 1607 032 2821 1567 030 2762 2225 063 37431998 1567 032 2754 1532 031 2701 2108 056 35531999 1518 034 2661 1477 032 2598 2093 069 35212000 1519 037 2664 1486 035 2617 2048 063 34362001 1477 035 2601 1437 033 2543 2052 065 34522002 1454 031 2562 1413 029 2502 2032 061 34142003 1431 031 2527 1389 030 2466 2024 047 34102004 1382 029 2449 1344 028 2394 1911 056 32292005 1361 029 2414 1318 028 2349 1937 049 32812006 1325 029 2356 1287 029 2302 1873 047 31622007 1290 028 2296 1251 027 2240 1851 045 31362008 1266 031 2255 1226 029 2199 1837 060 30962009 1243 028 2224 1209 028 2176 1778 041 30192010 1226 030 2192 1185 028 2133 1778 059 30162011 1202 030 2155 1160 028 2094 1771 050 30172012 1183 026 2128 1144 025 2072 1723 042 29402013 1153 030 2075 1120 028 2030 1658 055 28222014 1141 029 2057 1104 027 2005 1646 054 28082015 1126 028 2034 1089 026 1981 1616 054 27622016 1108 027 2006 1075 026 1959 1596 044 27362017 1100 029 1988 1063 027 1937 1570 050 2690

Table 46Cancer of the Breast (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

Year of Diagnosis1975-1979 10213 3934 26656 10481 3977 27512 8794 3933 215221980 10224 3775 27112 10514 3828 28024 8948 3769 225121981 10635 3919 28222 10989 4005 29275 9420 3866 239641982 10650 4057 27914 10994 4126 28980 9358 3802 239061983 11111 4026 29664 11446 4084 30722 10364 4160 266091984 11599 4239 30872 11989 4317 32079 10241 4466 253621985 12430 4440 33352 12779 4437 34622 11189 4587 284761986 12686 4453 34243 13040 4532 35318 11533 4564 297821987 13451 4554 36748 14025 4647 38580 10953 4309 283481988 13139 4401 36020 13627 4492 37547 11901 4300 318061989 12730 4347 34682 13245 4454 36265 10523 4233 269961990 13191 4565 35779 13627 4541 37419 11898 4905 302081991 13388 4731 36058 13891 4732 37875 11751 5100 291671992 13213 4347 36427 13574 4364 37691 12439 4686 327421993 12924 4287 35541 13310 4322 36847 11986 4550 314601994 13101 4243 36296 13572 4281 37899 12296 4774 319941995 13276 4327 36710 13766 4377 38350 12409 4584 329001996 13383 4363 37001 13825 4401 38500 12473 4450 334801997 13811 4359 38563 14267 4408 40083 12633 4495 339421998 14148 4555 39269 14651 4543 41119 12638 4743 333141999 14158 4389 39738 14714 4510 41433 12674 4411 343112000 13666 4355 38046 14307 4399 40251 11941 4530 313492001 13894 4407 38735 14509 4486 40757 11670 4002 317512002 13594 4293 37950 14126 4353 39718 12454 4167 341552003 12713 4345 34624 13190 4432 36122 12392 4348 334542004 12837 4512 34638 13211 4491 36047 12478 4837 324862005 12676 4417 34303 13142 4452 35899 11925 4584 311502006 12651 4423 34198 13064 4514 35453 12578 4530 336522007 12846 4542 34588 13263 4577 36007 12497 4549 333102008 12863 4562 34601 13169 4561 35711 12880 4540 347182009 13113 4559 35511 13472 4612 36674 13003 4587 350412010 12744 4436 34498 13140 4522 35706 12356 4447 330672011 13085 4562 35405 13432 4567 36644 12936 4881 340302012 13071 4449 35649 13338 4515 36441 13464 4259 375672013 13165 4563 35690 13426 4612 36506 13053 4222 361792014 13209 4621 35698 13494 4605 36771 12928 4638 346372015 13255 4680 35708 13549 4685 36761 13145 4608 354982016 13162 4563 35680 13497 4570 36873 13148 4854 348662017 13306 4749 35712 13711 4908 36760 12455 4320 33756

Table 47Cancer of the Female Breast (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

Year of Diagnosis1975-2017 12678 4386 34392 13032 4424 35574 11953 4453 315921975-1979 10213 3934 26656 10481 3977 27512 8794 3933 215221980 10224 3775 27112 10514 3828 28024 8948 3769 225121981 10635 3919 28222 10989 4005 29275 9420 3866 239641982 10650 4057 27914 10994 4126 28980 9358 3802 239061983 11111 4026 29664 11446 4084 30722 10364 4160 266091984 11599 4239 30872 11989 4317 32079 10241 4466 253621985 12430 4440 33352 12779 4437 34622 11189 4587 284761986 12686 4453 34243 13040 4532 35318 11533 4564 297821987 13451 4554 36748 14025 4647 38580 10953 4309 283481988 13139 4401 36020 13627 4492 37547 11901 4300 318061989 12730 4347 34682 13245 4454 36265 10523 4233 269961990 13191 4565 35779 13627 4541 37419 11898 4905 302081991 13388 4731 36058 13891 4732 37875 11751 5100 291671992 13213 4347 36427 13574 4364 37691 12439 4686 327421993 12924 4287 35541 13310 4322 36847 11986 4550 314601994 13101 4243 36296 13572 4281 37899 12296 4774 319941995 13276 4327 36710 13766 4377 38350 12409 4584 329001996 13383 4363 37001 13825 4401 38500 12473 4450 334801997 13811 4359 38563 14267 4408 40083 12633 4495 339421998 14148 4555 39269 14651 4543 41119 12638 4743 333141999 14158 4389 39738 14714 4510 41433 12674 4411 343112000 13666 4355 38046 14307 4399 40251 11941 4530 313492001 13894 4407 38735 14509 4486 40757 11670 4002 317512002 13594 4293 37950 14126 4353 39718 12454 4167 341552003 12713 4345 34624 13190 4432 36122 12392 4348 334542004 12837 4512 34638 13211 4491 36047 12478 4837 324862005 12676 4417 34303 13142 4452 35899 11925 4584 311502006 12651 4423 34198 13064 4514 35453 12578 4530 336522007 12846 4542 34588 13263 4577 36007 12497 4549 333102008 12863 4562 34601 13169 4561 35711 12880 4540 347182009 13104 4556 35487 13461 4608 36642 12985 4581 349912010 12726 4429 34452 13117 4514 35645 12321 4435 329692011 13058 4552 35332 13398 4556 36550 12879 4861 338742012 13035 4436 35552 13293 4501 36316 13384 4237 373372013 13120 4547 35569 13369 4594 36349 12961 4192 359242014 13155 4602 35553 13426 4583 36584 12818 4598 343402015 13182 4655 35513 13461 4656 36516 12992 4556 350822016 13068 4531 35421 13373 4531 36529 12949 4782 343342017 13161 4701 35317 13514 4841 36226 12192 4234 33030

Table 48Cancer of the Female Breast (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

Year of Death1975-2017 2694 640 8075 2677 606 8103 3272 989 92521975-1979 3174 880 9181 3200 864 9318 3116 1084 84381980 3168 857 9222 3193 839 9356 3168 1082 86311981 3192 846 9333 3212 820 9477 3255 1148 87741982 3219 842 9443 3231 819 9546 3375 1119 92831983 3207 816 9470 3220 789 9585 3353 1117 92101984 3290 858 9657 3290 822 9755 3594 1255 97211985 3298 856 9690 3311 830 9809 3485 1204 94581986 3287 864 9632 3293 826 9753 3544 1286 94581987 3266 844 9608 3257 799 9693 3673 1294 99041988 3320 839 9818 3309 801 9878 3778 1271 103421989 3323 842 9822 3323 806 9916 3661 1241 99961990 3314 832 9814 3302 799 9855 3800 1199 106131991 3269 816 9691 3245 773 9715 3828 1231 106291992 3164 777 9415 3143 737 9445 3709 1203 102731993 3139 741 9418 3109 699 9420 3804 1165 107141994 3092 737 9258 3056 692 9247 3774 1170 105911995 3055 729 9146 3009 680 9107 3818 1171 107491996 2949 695 8853 2905 640 8835 3713 1174 103611997 2821 671 8453 2762 622 8364 3743 1103 106561998 2754 634 8305 2701 582 8250 3553 1065 100681999 2661 575 8122 2598 520 8040 3521 1027 100522000 2664 589 8099 2617 537 8064 3436 994 98312001 2601 586 7877 2543 536 7798 3452 985 99122002 2562 563 7797 2502 507 7728 3414 1002 97312003 2527 558 7685 2466 508 7590 3410 962 98192004 2449 521 7499 2394 467 7438 3229 926 92602005 2414 520 7374 2349 465 7283 3281 946 93952006 2356 505 7201 2302 458 7132 3162 888 91172007 2296 477 7060 2240 428 6985 3136 855 91102008 2255 474 6920 2199 432 6823 3096 823 90472009 2224 481 6788 2176 448 6701 3019 796 88392010 2192 453 6747 2133 408 6653 3016 802 88142011 2155 447 6628 2094 403 6520 3017 783 88652012 2128 459 6498 2072 415 6408 2940 789 85732013 2075 442 6353 2030 407 6278 2822 732 82952014 2057 437 6299 2005 397 6216 2808 755 81852015 2034 427 6240 1981 394 6137 2762 695 81762016 2006 439 6109 1959 401 6040 2736 744 79542017 1988 420 6094 1937 383 6005 2690 696 7913

Table 49Cancer of the Female Breast (Invasive)

Age-adjusted US Deatha Rates by Year Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

Year of Diagnosis1975-2017 2520 1026 6431 2497 1032 6333 2557 874 69641975-1979 486 284 1016 496 293 1027 369 199 8131980 480 296 963 502 307 1012 371 - -1981 497 264 1105 495 252 1131 411 - 8841982 530 273 1203 534 271 1224 555 273 12941983 609 303 1409 621 302 1457 541 - 13201984 862 479 1866 919 520 1964 635 237 16771985 1153 591 2624 1211 627 2740 828 345 20921986 1362 677 3156 1422 719 3263 953 512 21091987 1738 782 4239 1825 827 4436 1220 564 29401988 1758 815 4227 1811 850 4328 1603 706 39521989 1654 702 4148 1711 728 4284 1464 552 38531990 1914 838 4730 1988 870 4916 1524 566 40321991 1979 879 4861 2051 892 5087 1552 729 37081992 2143 901 5397 2215 923 5600 1904 693 50761993 2070 836 5304 2134 877 5425 1672 606 44651994 2231 874 5784 2288 900 5922 2010 756 52961995 2472 962 6424 2509 999 6464 2280 650 65501996 2539 985 6607 2596 987 6811 2301 768 63131997 2835 1104 7366 2889 1117 7529 2867 1158 73431998 3277 1200 8716 3374 1231 8986 3089 1096 83091999 3275 1201 8706 3324 1224 8825 2994 1056 80682000 3286 1181 8797 3392 1250 8999 3012 804 87932001 3369 1158 9159 3420 1199 9234 3212 925 92002002 3405 1189 9207 3456 1228 9293 2889 885 81372003 3251 1204 8609 3352 1253 8847 3022 950 84482004 3324 1280 8677 3399 1302 8890 3076 1026 84452005 3264 1252 8533 3354 1301 8729 3256 1050 90322006 3327 1383 8416 3361 1440 8392 3628 1174 100552007 3539 1437 9042 3586 1487 9083 3375 1116 92892008 3691 1415 9653 3724 1476 9611 3688 1173 102732009 3702 1443 9617 3777 1499 9742 3569 1146 99112010 3392 1316 8828 3432 1322 8957 3319 1223 88082011 3561 1442 9109 3600 1484 9140 3412 1084 95092012 3342 1362 8525 3308 1394 8320 3526 1171 96952013 3491 1445 8847 3441 1451 8652 3692 1221 101622014 3459 1438 8751 3384 1455 8436 3734 1198 103742015 3357 1312 8712 3278 1311 8431 3576 1039 102192016 3205 1315 8154 3161 1351 7898 3440 1175 93722017 3233 1298 8300 3154 1257 8121 3262 1079 8978

Table 410Cancer of the Female Breast (In Situ)

Age-adjusted SEER Incidencea Rates by Year Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 689 12 1285 695 12 1313 713 18 1248Under 65 435 05 848 432 04 855 454 08 83965 and over 2441 65 4303 2514 66 4477 2503 87 4075

All ages (WHO world std)c 539 09 1018 542 09 1037 558 13 992

Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 - - - - - - - - -5-9 - - - - - - - - -10-14 - - - - - - - - -15-19 01 - 02 01 - 01 - - -20-24 08 - 16 08 - 16 10 - 2025-29 49 - 100 48 - 99 57 - 11430-34 146 01 294 142 - 289 169 - 32535-39 324 02 644 313 02 635 378 - 71040-44 662 04 1307 651 03 1310 677 10 126145-49 1001 08 1971 995 07 1991 975 16 181850-54 1210 12 2364 1205 12 2385 1248 19 232155-59 1394 21 2690 1387 19 2712 1506 36 276660-64 1803 31 3423 1816 31 3495 1865 42 334165-69 2286 46 4265 2333 45 4413 2318 77 402170-74 2583 60 4702 2658 59 4895 2543 83 428175-79 2608 71 4589 2706 74 4808 2706 87 439680-84 2472 90 4135 2566 92 4333 2558 104 393485+ 2167 79 3261 2222 83 3353 2409 100 3381

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 113 03 203 109 03 198 162 05 276Under 65 51 01 99 47 01 92 84 02 15565 and over 539 16 926 538 16 931 701 29 1117

All ages (WHO world std)c 70 02 130 67 02 126 105 03 185

Age-Specific Rates 2013-2017lt1 - - - - - - - - -1-4 - - - - - - - - -5-9 - - - - - - - - -10-14 - - - - - - - - -15-19 - - - - - - - - -20-24 00 - 01 00 - 01 01 - 0225-29 04 - 07 03 - 06 08 - 1530-34 14 - 28 12 - 25 25 - 4835-39 33 00 66 30 - 61 57 - 10740-44 61 01 121 55 01 111 109 - 20545-49 96 02 189 87 01 173 167 04 31150-54 146 03 284 134 02 263 246 05 45855-59 196 04 378 184 04 357 308 08 56760-64 254 06 481 243 06 465 380 09 68265-69 323 10 604 315 09 594 474 20 82670-74 406 12 743 403 11 746 536 24 90575-79 523 16 929 522 15 936 681 28 111080-84 687 23 1160 689 23 1174 880 40 135685+ 1148 31 1738 1158 31 1762 1373 45 1931

Table 411Cancer of the Breast (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Females White Females Black Females Age-Adjusted Rates 2013-2017Age at Diagnosis

All ages 330 328 330Under 65 251 251 22765 and over 874 854 1042

All ages (WHO world std)b 269 267 267

Age-Specific Rates 2013-2017Age at Diagnosis

lt1 - - -1-4 - - -5-9 - - -10-14 - - -15-19 - - -20-24 02 02 -25-29 09 08 0930-34 33 33 2935-39 105 105 10440-44 456 460 36545-49 692 702 53350-54 778 787 66755-59 767 757 77860-64 895 870 101965-69 1074 1040 123670-74 1082 1056 128475-79 895 880 111680-84 621 616 74185+ 261 256 330

Table 412Cancer of the Female Breast(In Situ)

SEER Incidencea Rates Age-Adjusted and Age-Specific Rates by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage pointsj In situ cases are not included in the All Stages group- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 63 - - 46 - -1970-1973a - - - 68 - - 51 - -1975-1977b 748 765 743 756 778 749 622 624 6201978-1980b 744 755 741 751 761 749 634 670 6151981-1983b 761 774 757 771 786 767 634 650 6261984-1986b 789 778 793 800 795 801 651 640 6591987-1989b 840 814 849 851 827 859 711 696 7191990-1992b 852 834 859 865 851 869 715 701 7241993-1995b 864 843 871 876 862 881 728 705 7421996-1998b 882 866 888 893 883 897 763 741 7761999-2001b 897 881 903 908 899 911 790 770 8012002-2004b 900 893 902 914 911 915 780 776 7822005-2009b 909 912 909 922 925 921 812 824 8062010-2016b 914f 912f 915f 925f 925f 925f 834f 826f 838f

5-Year Period Survival (Percent)cd2016 903 900 904 912 911 912 826 815 830

Stage Distribution () 2010-2016ceAll StagesNumber of cases 356026 79017 277009 278199 57351 220848 40580 10659 29921Percent 100 100 100 100 100 100 100 100 100Localized 63 55 65 64 55 66 55 48 57Regional 30 39 27 29 38 27 35 42 32Distant 6 5 6 6 5 6 9 9 9UnstagedUnknown 2 1 2 1 1 2 2 2 2

5-Year Relative Survival (Percent) 2010-2016cAge at DiagnosisAges lt45 881 - - 893 - - 792 - -Ages 45-54 911 - - 922 - - 828 - -Ages 55-64 905 - - 915 - - 830 - -Ages 65-74 921 - - 928 - - 853 - -Ages 75+ 860 - - 870 - - 768 - -Ages lt65 902 - - 913 - - 821 - -Ages 65+ 897 - - 904 - - 820 - -

StageeAll Stages 900 897 901 909 909 909 820 811 824Localized 989 971 993 992 974 996 961 940 968Regional 857 873 850 868 886 861 777 786 773Distant 281 376 256 294 408 268 194 262 169UnstagedUnknown 551 751 504 527 749 485 503 696 430In Situ j 1000 1000 1000 1000 1000 1000 1000 999 1000

Table 413Cancer of the Female Breast (Invasive)

5-Year Relative and Period Survival (Percent) by Race Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Females White Females Black Females Age-Adjusted Rates 2013-2017Age at Diagnosis

All ages 330 328 330Under 65 251 251 22765 and over 874 854 1042

All ages (WHO world std)b 269 267 267

Age-Specific Rates 2013-2017Age at Diagnosis

lt1 - - -1-4 - - -5-9 - - -10-14 - - -15-19 - - -20-24 02 02 -25-29 09 08 0930-34 33 33 2935-39 105 105 10440-44 456 460 36545-49 692 702 53350-54 778 787 66755-59 767 757 77860-64 895 870 101965-69 1074 1040 123670-74 1082 1056 128475-79 895 880 111680-84 621 616 74185+ 261 256 330

Table 412Cancer of the Female Breast(In Situ)

SEER Incidencea Rates Age-Adjusted and Age-Specific Rates by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage pointsj In situ cases are not included in the All Stages group- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 63 - - 46 - -1970-1973a - - - 68 - - 51 - -1975-1977b 748 765 743 756 778 749 622 624 6201978-1980b 744 755 741 751 761 749 634 670 6151981-1983b 761 774 757 771 786 767 634 650 6261984-1986b 789 778 793 800 795 801 651 640 6591987-1989b 840 814 849 851 827 859 711 696 7191990-1992b 852 834 859 865 851 869 715 701 7241993-1995b 864 843 871 876 862 881 728 705 7421996-1998b 882 866 888 893 883 897 763 741 7761999-2001b 897 881 903 908 899 911 790 770 8012002-2004b 900 893 902 914 911 915 780 776 7822005-2009b 909 912 909 922 925 921 812 824 8062010-2016b 914f 912f 915f 925f 925f 925f 834f 826f 838f

5-Year Period Survival (Percent)cd2016 903 900 904 912 911 912 826 815 830

Stage Distribution () 2010-2016ceAll StagesNumber of cases 356026 79017 277009 278199 57351 220848 40580 10659 29921Percent 100 100 100 100 100 100 100 100 100Localized 63 55 65 64 55 66 55 48 57Regional 30 39 27 29 38 27 35 42 32Distant 6 5 6 6 5 6 9 9 9UnstagedUnknown 2 1 2 1 1 2 2 2 2

5-Year Relative Survival (Percent) 2010-2016cAge at DiagnosisAges lt45 881 - - 893 - - 792 - -Ages 45-54 911 - - 922 - - 828 - -Ages 55-64 905 - - 915 - - 830 - -Ages 65-74 921 - - 928 - - 853 - -Ages 75+ 860 - - 870 - - 768 - -Ages lt65 902 - - 913 - - 821 - -Ages 65+ 897 - - 904 - - 820 - -

StageeAll Stages 900 897 901 909 909 909 820 811 824Localized 989 971 993 992 974 996 961 940 968Regional 857 873 850 868 886 861 777 786 773Distant 281 376 256 294 408 268 194 262 169UnstagedUnknown 551 751 504 527 749 485 503 696 430In Situ j 1000 1000 1000 1000 1000 1000 1000 999 1000

Table 413Cancer of the Female Breast (Invasive)

5-Year Relative and Period Survival (Percent) by Race Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage pointsj In situ cases are not included in the All Stages group- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Females White Females Black Females All lt50 50+ All lt50 50+ All lt50 50+

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 63 - - 46 - -1970-1973a - - - 68 - - 51 - -1975-1977b 748 765 743 756 778 749 622 624 6201978-1980b 744 755 741 751 761 749 634 670 6151981-1983b 761 774 757 771 786 767 634 650 6261984-1986b 789 778 793 800 795 801 651 640 6591987-1989b 840 814 849 851 827 859 711 696 7191990-1992b 852 834 859 865 851 869 715 701 7241993-1995b 864 843 871 876 862 881 728 705 7421996-1998b 882 866 888 893 883 897 763 741 7761999-2001b 897 881 903 908 899 911 790 770 8012002-2004b 900 893 902 914 911 915 780 776 7822005-2009b 909 912 909 922 925 921 812 824 8062010-2016b 914f 912f 915f 925f 925f 925f 834f 826f 838f

5-Year Period Survival (Percent)cd2016 903 900 904 912 911 912 826 815 830

Stage Distribution () 2010-2016ceAll StagesNumber of cases 356026 79017 277009 278199 57351 220848 40580 10659 29921Percent 100 100 100 100 100 100 100 100 100Localized 63 55 65 64 55 66 55 48 57Regional 30 39 27 29 38 27 35 42 32Distant 6 5 6 6 5 6 9 9 9UnstagedUnknown 2 1 2 1 1 2 2 2 2

5-Year Relative Survival (Percent) 2010-2016cAge at DiagnosisAges lt45 881 - - 893 - - 792 - -Ages 45-54 911 - - 922 - - 828 - -Ages 55-64 905 - - 915 - - 830 - -Ages 65-74 921 - - 928 - - 853 - -Ages 75+ 860 - - 870 - - 768 - -Ages lt65 902 - - 913 - - 821 - -Ages 65+ 897 - - 904 - - 820 - -

StageeAll Stages 900 897 901 909 909 909 820 811 824Localized 989 971 993 992 974 996 961 940 968Regional 857 873 850 868 886 861 777 786 773Distant 281 376 256 294 408 268 194 262 169UnstagedUnknown 551 751 504 527 749 485 503 696 430In Situ j 1000 1000 1000 1000 1000 1000 1000 999 1000

Table 413Cancer of the Female Breast (Invasive)

5-Year Relative and Period Survival (Percent) by Race Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 944 951 963 971 971 969 973 975 975 975 973 975 978 978 977 977 977 977 978 976 978 981 980 976 981 9772-year 887 899 923 938 940 936 943 950 952 953 950 955 955 956 957 957 961 957 960 958 961 960 962 960 9643-year 831 846 883 905 914 909 920 929 931 934 928 936 933 933 938 938 940 938 940 940 945 941 945 9434-year 785 802 851 878 888 889 899 911 913 916 910 918 916 914 919 923 925 924 926 923 928 926 9315-year 746 763 822 856 868 866 884 895 896 901 894 902 898 900 905 908 912 907 914 910 915 9126-year 714 734 798 838 854 850 869 883 881 890 882 888 886 887 892 897 899 895 905 901 9037-year 687 707 779 821 838 838 859 871 870 877 869 877 875 875 881 888 890 884 894 8938-year 665 684 763 810 826 824 850 858 859 864 860 865 864 866 874 878 881 874 8869-year 643 664 746 798 814 813 837 846 850 853 852 856 859 857 866 869 871 86510-year 625 645 733 787 806 804 826 835 842 845 844 851 848 849 858 860 86211-year 608 627 721 777 795 795 818 827 830 836 837 845 840 844 851 85312-year 593 616 709 767 785 786 811 821 825 826 825 835 834 839 84213-year 581 604 698 758 775 776 801 811 818 818 819 827 829 83014-year 571 592 690 750 769 769 794 805 808 812 811 822 82215-year 561 583 681 742 760 762 785 795 803 805 805 81716-year 552 573 673 733 750 756 775 789 795 800 79917-year 542 563 665 724 742 749 771 782 790 79418-year 534 556 657 717 730 742 764 777 78119-year 526 550 651 711 725 732 755 76720-year 519 542 645 703 719 724 74621-year 511 535 638 694 712 71222-year 506 528 632 687 70523-year 501 522 626 68224-year 494 516 62025-year 487 511 61426-year 484 507 60627-year 480 501 59728-year 476 496 59129-year 471 48830-year 467 482

Table 414Cancer of the Female Breast (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 966 974 978 980 979 977 979 983 986 984 982 985 988 985 988 988 990 987 988 986 991 988 985 988 989 9852-year 908 912 925 938 936 938 946 951 950 955 945 957 961 959 961 968 971 963 965 963 971 966 966 966 9693-year 845 855 874 897 900 907 916 922 922 930 917 933 937 933 938 948 951 941 943 940 952 944 949 9484-year 800 809 834 863 867 882 887 895 901 906 893 906 918 912 922 931 935 925 926 920 931 926 9325-year 761 770 801 838 842 855 867 873 881 890 873 887 898 894 907 912 919 910 912 907 915 9116-year 732 742 779 818 823 833 847 854 861 873 853 869 881 879 894 897 905 896 898 896 9027-year 709 716 758 800 803 817 832 837 848 857 837 854 868 864 883 888 891 884 885 8858-year 689 695 742 785 788 801 815 824 836 838 822 843 857 853 874 877 882 875 8779-year 670 678 726 774 777 791 805 809 826 826 811 833 850 844 865 870 871 86510-year 656 664 715 763 764 777 793 798 816 816 803 825 841 835 857 861 86411-year 642 651 704 754 756 768 782 790 804 808 794 818 831 830 852 85812-year 629 641 693 745 747 761 774 782 800 801 786 807 826 824 84413-year 617 631 683 735 738 748 764 776 793 794 778 801 820 81914-year 610 620 676 728 731 742 754 773 781 790 774 795 81415-year 602 612 669 722 724 735 749 767 776 784 769 79216-year 595 605 662 715 716 731 742 761 771 779 76417-year 590 599 656 708 706 725 737 755 762 77318-year 584 593 650 702 696 721 728 752 75619-year 578 588 644 697 687 716 723 74820-year 571 583 640 692 682 710 71721-year 564 575 634 687 677 70122-year 559 568 629 684 66923-year 553 562 625 68024-year 547 557 62125-year 541 552 61626-year 538 547 61027-year 532 542 60428-year 528 536 59929-year 525 53130-year 521 527

Table 415Cancer of the Female Breast (Ages lt50 Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 937 944 958 967 968 967 971 972 972 972 970 972 975 975 974 974 973 974 975 973 974 979 978 972 978 9752-year 881 896 923 938 941 936 942 949 952 953 952 954 953 955 956 953 957 955 959 957 957 959 961 958 9623-year 827 843 887 907 919 910 922 932 934 936 932 937 932 933 938 935 937 937 939 940 942 940 944 9424-year 780 800 857 884 896 892 903 916 918 920 916 922 915 915 919 921 922 924 925 924 927 926 9305-year 741 761 829 863 878 871 889 903 901 906 901 907 898 902 905 907 910 907 915 910 915 9136-year 708 731 805 846 866 856 878 894 888 896 892 895 889 889 892 898 898 895 907 903 9037-year 680 704 786 829 851 846 869 884 878 884 880 885 878 880 880 888 890 884 897 8968-year 656 680 771 819 841 833 863 872 867 874 873 873 866 871 874 878 881 874 8899-year 633 659 753 807 828 822 849 861 859 863 868 865 863 862 867 869 871 86510-year 613 638 739 796 822 814 839 849 851 855 860 861 851 854 859 860 86211-year 596 619 727 785 810 806 832 841 840 846 852 855 844 850 851 85112-year 580 606 714 776 800 796 825 836 834 836 840 845 838 845 84113-year 567 594 703 767 788 787 815 825 827 828 835 836 833 83514-year 556 581 694 757 783 780 809 817 817 821 824 832 82615-year 544 572 684 749 774 774 799 805 814 813 817 82516-year 534 560 675 740 763 767 788 798 804 807 81217-year 521 548 666 729 755 759 783 792 801 80118-year 513 541 658 721 743 749 779 785 79019-year 504 533 652 714 741 737 767 77220-year 496 525 645 705 734 728 75621-year 488 517 637 693 725 71322-year 483 510 630 684 71923-year 477 504 624 67724-year 470 497 61625-year 461 492 60826-year 458 489 59727-year 454 483 58728-year 451 477 57929-year 445 46630-year 440 457

Table 416Cancer of the Female Breast (Ages 50+ Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 000 007 1286 254 Asian 0 000 000 006 1095 178

10 000 007 055 1298 257 Pacific 10 000 006 049 1102 179

20 007 055 207 1301 258 Islander 20 005 049 202 1103 179

30 049 202 431 1301 259 30 044 197 409 1101 179

40 155 388 710 1269 256 40 155 369 638 1065 177

50 240 573 912 1151 246 50 219 494 743 932 167

60 354 716 920 970 225 60 287 546 690 743 147

70 409 639 - 696 192 70 279 434 - 491 122

80 301 - - 376 151 80 181 - - 247 095

White 0 000 000 007 1313 251 American 0 000 000 005 792 190

10 000 007 055 1324 253 Indian 10 000 005 033 799 192

20 007 054 207 1326 254 Alaska 20 005 033 115 801 193

30 048 202 433 1327 255 Nativea 30 029 112 238 806 194

40 156 390 721 1296 253 40 085 214 414 794 196

50 242 583 936 1177 244 50 135 342 545 737 193

60 364 740 948 996 224 60 222 438 604 644 185

70 425 662 - 716 192 70 244 430 - 475 168

80 312 - - 383 151 80 243 - - 301 134

Black 0 000 000 008 1165 305 Hispanicb 0 000 000 006 1061 202

10 000 008 060 1185 311 10 000 006 046 1069 204

20 007 060 200 1187 312 20 006 046 167 1071 204

30 053 194 417 1188 313 30 040 162 351 1069 205

40 144 371 661 1156 309 40 123 314 581 1039 202

50 236 537 831 1053 293 50 196 469 734 938 193

60 328 647 829 889 261 60 286 564 725 778 174

70 374 587 - 657 221 70 306 484 - 541 149

80 291 - - 385 178 80 218 - - 289 122

Table 417

Cancer of the Female Breast (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Females Females Females RaceEthnicity

All Races 1285 03 03

White 1313 02 02White Hispanice 1012 03 -White Non-Hispanice 1373 03 -

Black 1248 06 03

AsianPacific Islander 1029 10 -

Amer IndAlaska Natf 795 01 -

Hispanice 991 05 -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Females FemalesRaceEthnicity

All Races 203 -15

White 198 -15White Hispanice 149 -10White Non-Hispanice 203 -14

Black 276 -15

AsianPacific Islander 114 -07

Amer IndAlaska NatTotal US 115 -04PRCDA Counties 146 01Non-PRCDA Counties 81 -37

Hispanice 140 -11

Table 418Cancer of the Female Breast (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Females Females Females RaceEthnicity

All Races 330 -11 -10

White 328 -18 -14White Hispanice 253 05 -White Non-Hispanice 346 -18 -

Black 330 07 -04

AsianPacific Islander 329 08 -

Amer IndAlaska Natf 164 00 -

Hispanice 252 09 -

Table 419Cancer of the Female Breast (In Situ)

SEER IncidenceAge-Adjusted Rates and Trendsa

By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 12152 4248 32849 12538 4245 34255 12038 3990 33115Greater Bay Area 12640 4655 33551 13540 4801 36425 12248 4301 33060San Francisco-Oakland 12883 4706 34296 13776 4807 37261 12398 4434 33251San Jose-Monterey 12177 4563 32116 13134 4796 34966 11328 3537 31729

Los Angeles 11656 4180 31232 11914 4081 32424 12134 4072 33245Greater California 12204 4130 33345 12507 4164 34354 11836 3778 32935

Connecticut 14055 5259 37087 14185 5325 37385 11705 4102 31613Detroit 13348 4727 35922 13647 4923 36493 13197 4572 35783Georgia 12680 4373 34433 12684 4269 34720 13022 4675 34878Atlanta 13296 4605 36054 13844 4728 37716 13249 4679 35690Rural Georgia 13121 4313 36184 14008 4891 37880 11032 3156 31657Greater Georgia 12354 4223 33646 12225 4059 33607 12923 4708 34436

Hawaii 13892 5131 36836 14343 5788 36744 9920 3433 26907Idaho 12671 4092 35136 12662 4069 35165 - - -Iowa 12895 4469 34959 12981 4532 35108 11189 4311 29201Kentucky 12669 4321 34531 12704 4313 34678 12500 4362 33811Louisiana 12586 4304 34272 12294 4061 33852 13519 4798 36354Massachusetts 13786 4981 36843 14021 5004 37634 11603 4541 30098New Jersey 13660 5035 36245 13948 5112 37086 12817 4622 34278New Mexico 11175 3574 31079 11588 3744 32130 7899 2578 21832New York 13277 5004 34942 13773 5093 36502 11963 4543 31392Seattle-Puget Sound 14028 4679 38507 14424 4622 40094 12489 4183 34240Utah 11436 3862 31269 11561 3866 31711 7986 - 22637

SEER 9 Areasb 13137 4607 35472 13429 4641 36441 12770 4473 34498SEER 13 Areasb 12749 4501 34348 13088 4511 35547 12611 4375 34175SEER 18 Areasb 12680 4432 34278 12913 4422 35147 12727 4449 34405SEER 21 Areasb 12849 4556 34564 13126 4563 35550 12480 4473 33447

Table 420Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Death Ratesa 2013-2017

California 1957 419 5982 2042 410 6314 2902 803 8398Greater Bay Area 1743 356 5377 1912 346 6011 2571 764 7303San Francisco-Oakland 1777 374 5450 1915 338 6043 2567 818 7146San Jose-Monterey 1679 324 5228 1906 360 5952 2604 - 8212

Los Angeles 1976 453 5965 1993 418 6115 3015 853 8676Greater California 2023 426 6203 2097 425 6474 2945 769 8645

Connecticut 1785 410 5384 1782 394 5416 2029 609 5749Detroit 2200 468 6737 2042 430 6261 2880 640 8745Georgia 2200 498 6657 1970 390 6107 2831 717 8367Atlanta 2250 522 6772 1869 377 5775 2983 720 8908Rural Georgia 2411 - 8049 1998 - 7001 3123 - 10011Greater Georgia 2168 487 6569 2004 399 6206 2714 719 7936

Hawaii 1609 321 4983 2018 - 6426 - - -Idaho 2159 396 6777 2194 399 6893 - - -Iowa 1867 370 5784 1867 363 5806 1976 - 5396Kentucky 2119 486 6393 2104 473 6377 2507 731 7157Louisiana 2308 530 6966 1955 377 6087 3213 851 9397Massachusetts 1780 386 5431 1825 403 5548 1832 377 5641New Jersey 2131 438 6564 2086 392 6523 2910 788 8466New Mexico 1929 389 5960 2023 414 6236 1752 - 4850New York 1928 417 5887 1933 376 6009 2300 633 6666Seattle-Puget Sound 1991 345 6301 2064 335 6590 2169 585 6316Utah 2010 400 6228 2025 394 6297 - - -

SEER 9 Areasb 1947 406 5981 1942 375 6045 2711 688 8009SEER 13 Areasb 1940 412 5943 1952 384 6058 2786 718 8200SEER 18 Areasb 2026 433 6198 2017 401 6248 2857 749 8376SEER 21 Areasb 1995 427 6101 1991 397 6165 2675 707 7827

Total US 2031 433 6215 1982 397 6132 2762 724 8099

Table 421Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 2794 1035 7401 2693 989 7155 2853 795 8241Greater Bay Area 3251 1326 8290 3106 1267 7922 2944 873 8366San Francisco-Oakland 3502 1438 8907 3378 1372 8631 3035 876 8688San Jose-Monterey 2775 1124 7098 2631 1085 6680 2296 - 6077

Los Angeles 2686 968 7185 2561 905 6897 2946 848 8439Greater California 2682 960 7190 2633 949 7042 2699 717 7887

Connecticut 4343 2110 10190 4380 2185 10128 3769 1447 9849Detroit 3565 1435 9142 3596 1583 8866 3713 1081 10606Georgia 2885 1087 7593 2785 1091 7221 3219 1052 8893Atlanta 3399 1312 8866 3469 1416 8845 3515 1187 9610Rural Georgia 2756 945 7498 2779 - 7297 2811 - 8046Greater Georgia 2611 944 6976 2524 951 6644 2963 919 8317

Hawaii 3530 1327 9299 2776 1119 7116 - - -Idaho 2338 1025 5777 2351 1045 5770 - - -Iowa 2811 1100 7293 2817 1122 7253 3067 - 8861Kentucky 2614 991 6866 2593 1006 6746 3028 893 8620Louisiana 2534 835 6983 2433 833 6622 2867 846 8160Massachusetts 3962 1871 9437 4023 1922 9524 3427 1384 8778New Jersey 4115 1902 9911 4192 1971 10008 3418 1273 9036New Mexico 2054 718 5552 2123 750 5719 1520 - -New York 4235 1976 10151 4352 2081 10300 3646 1323 9731Seattle-Puget Sound 3558 1366 9298 3469 1281 9198 3822 1223 10629Utah 2262 874 5898 2284 895 5920 - - -

SEER 9 Areasb 3346 1362 8541 3281 1366 8296 3535 1143 9798SEER 13 Areasb 3157 1251 8148 3081 1236 7914 3388 1080 9433SEER 18 Areasb 3050 1197 7902 2990 1190 7706 3179 1010 8857SEER 21 Areasb 3300 1365 8366 3275 1379 8242 3302 1099 9071

Table 422Cancer of the Female Breast (In Situ)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Females Females Females RaceEthnicity

All Races 330 -11 -10

White 328 -18 -14White Hispanice 253 05 -White Non-Hispanice 346 -18 -

Black 330 07 -04

AsianPacific Islander 329 08 -

Amer IndAlaska Natf 164 00 -

Hispanice 252 09 -

Table 419Cancer of the Female Breast (In Situ)

SEER IncidenceAge-Adjusted Rates and Trendsa

By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 12152 4248 32849 12538 4245 34255 12038 3990 33115Greater Bay Area 12640 4655 33551 13540 4801 36425 12248 4301 33060San Francisco-Oakland 12883 4706 34296 13776 4807 37261 12398 4434 33251San Jose-Monterey 12177 4563 32116 13134 4796 34966 11328 3537 31729

Los Angeles 11656 4180 31232 11914 4081 32424 12134 4072 33245Greater California 12204 4130 33345 12507 4164 34354 11836 3778 32935

Connecticut 14055 5259 37087 14185 5325 37385 11705 4102 31613Detroit 13348 4727 35922 13647 4923 36493 13197 4572 35783Georgia 12680 4373 34433 12684 4269 34720 13022 4675 34878Atlanta 13296 4605 36054 13844 4728 37716 13249 4679 35690Rural Georgia 13121 4313 36184 14008 4891 37880 11032 3156 31657Greater Georgia 12354 4223 33646 12225 4059 33607 12923 4708 34436

Hawaii 13892 5131 36836 14343 5788 36744 9920 3433 26907Idaho 12671 4092 35136 12662 4069 35165 - - -Iowa 12895 4469 34959 12981 4532 35108 11189 4311 29201Kentucky 12669 4321 34531 12704 4313 34678 12500 4362 33811Louisiana 12586 4304 34272 12294 4061 33852 13519 4798 36354Massachusetts 13786 4981 36843 14021 5004 37634 11603 4541 30098New Jersey 13660 5035 36245 13948 5112 37086 12817 4622 34278New Mexico 11175 3574 31079 11588 3744 32130 7899 2578 21832New York 13277 5004 34942 13773 5093 36502 11963 4543 31392Seattle-Puget Sound 14028 4679 38507 14424 4622 40094 12489 4183 34240Utah 11436 3862 31269 11561 3866 31711 7986 - 22637

SEER 9 Areasb 13137 4607 35472 13429 4641 36441 12770 4473 34498SEER 13 Areasb 12749 4501 34348 13088 4511 35547 12611 4375 34175SEER 18 Areasb 12680 4432 34278 12913 4422 35147 12727 4449 34405SEER 21 Areasb 12849 4556 34564 13126 4563 35550 12480 4473 33447

Table 420Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Death Ratesa 2013-2017

California 1957 419 5982 2042 410 6314 2902 803 8398Greater Bay Area 1743 356 5377 1912 346 6011 2571 764 7303San Francisco-Oakland 1777 374 5450 1915 338 6043 2567 818 7146San Jose-Monterey 1679 324 5228 1906 360 5952 2604 - 8212

Los Angeles 1976 453 5965 1993 418 6115 3015 853 8676Greater California 2023 426 6203 2097 425 6474 2945 769 8645

Connecticut 1785 410 5384 1782 394 5416 2029 609 5749Detroit 2200 468 6737 2042 430 6261 2880 640 8745Georgia 2200 498 6657 1970 390 6107 2831 717 8367Atlanta 2250 522 6772 1869 377 5775 2983 720 8908Rural Georgia 2411 - 8049 1998 - 7001 3123 - 10011Greater Georgia 2168 487 6569 2004 399 6206 2714 719 7936

Hawaii 1609 321 4983 2018 - 6426 - - -Idaho 2159 396 6777 2194 399 6893 - - -Iowa 1867 370 5784 1867 363 5806 1976 - 5396Kentucky 2119 486 6393 2104 473 6377 2507 731 7157Louisiana 2308 530 6966 1955 377 6087 3213 851 9397Massachusetts 1780 386 5431 1825 403 5548 1832 377 5641New Jersey 2131 438 6564 2086 392 6523 2910 788 8466New Mexico 1929 389 5960 2023 414 6236 1752 - 4850New York 1928 417 5887 1933 376 6009 2300 633 6666Seattle-Puget Sound 1991 345 6301 2064 335 6590 2169 585 6316Utah 2010 400 6228 2025 394 6297 - - -

SEER 9 Areasb 1947 406 5981 1942 375 6045 2711 688 8009SEER 13 Areasb 1940 412 5943 1952 384 6058 2786 718 8200SEER 18 Areasb 2026 433 6198 2017 401 6248 2857 749 8376SEER 21 Areasb 1995 427 6101 1991 397 6165 2675 707 7827

Total US 2031 433 6215 1982 397 6132 2762 724 8099

Table 421Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 2794 1035 7401 2693 989 7155 2853 795 8241Greater Bay Area 3251 1326 8290 3106 1267 7922 2944 873 8366San Francisco-Oakland 3502 1438 8907 3378 1372 8631 3035 876 8688San Jose-Monterey 2775 1124 7098 2631 1085 6680 2296 - 6077

Los Angeles 2686 968 7185 2561 905 6897 2946 848 8439Greater California 2682 960 7190 2633 949 7042 2699 717 7887

Connecticut 4343 2110 10190 4380 2185 10128 3769 1447 9849Detroit 3565 1435 9142 3596 1583 8866 3713 1081 10606Georgia 2885 1087 7593 2785 1091 7221 3219 1052 8893Atlanta 3399 1312 8866 3469 1416 8845 3515 1187 9610Rural Georgia 2756 945 7498 2779 - 7297 2811 - 8046Greater Georgia 2611 944 6976 2524 951 6644 2963 919 8317

Hawaii 3530 1327 9299 2776 1119 7116 - - -Idaho 2338 1025 5777 2351 1045 5770 - - -Iowa 2811 1100 7293 2817 1122 7253 3067 - 8861Kentucky 2614 991 6866 2593 1006 6746 3028 893 8620Louisiana 2534 835 6983 2433 833 6622 2867 846 8160Massachusetts 3962 1871 9437 4023 1922 9524 3427 1384 8778New Jersey 4115 1902 9911 4192 1971 10008 3418 1273 9036New Mexico 2054 718 5552 2123 750 5719 1520 - -New York 4235 1976 10151 4352 2081 10300 3646 1323 9731Seattle-Puget Sound 3558 1366 9298 3469 1281 9198 3822 1223 10629Utah 2262 874 5898 2284 895 5920 - - -

SEER 9 Areasb 3346 1362 8541 3281 1366 8296 3535 1143 9798SEER 13 Areasb 3157 1251 8148 3081 1236 7914 3388 1080 9433SEER 18 Areasb 3050 1197 7902 2990 1190 7706 3179 1010 8857SEER 21 Areasb 3300 1365 8366 3275 1379 8242 3302 1099 9071

Table 422Cancer of the Female Breast (In Situ)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 12152 4248 32849 12538 4245 34255 12038 3990 33115Greater Bay Area 12640 4655 33551 13540 4801 36425 12248 4301 33060San Francisco-Oakland 12883 4706 34296 13776 4807 37261 12398 4434 33251San Jose-Monterey 12177 4563 32116 13134 4796 34966 11328 3537 31729

Los Angeles 11656 4180 31232 11914 4081 32424 12134 4072 33245Greater California 12204 4130 33345 12507 4164 34354 11836 3778 32935

Connecticut 14055 5259 37087 14185 5325 37385 11705 4102 31613Detroit 13348 4727 35922 13647 4923 36493 13197 4572 35783Georgia 12680 4373 34433 12684 4269 34720 13022 4675 34878Atlanta 13296 4605 36054 13844 4728 37716 13249 4679 35690Rural Georgia 13121 4313 36184 14008 4891 37880 11032 3156 31657Greater Georgia 12354 4223 33646 12225 4059 33607 12923 4708 34436

Hawaii 13892 5131 36836 14343 5788 36744 9920 3433 26907Idaho 12671 4092 35136 12662 4069 35165 - - -Iowa 12895 4469 34959 12981 4532 35108 11189 4311 29201Kentucky 12669 4321 34531 12704 4313 34678 12500 4362 33811Louisiana 12586 4304 34272 12294 4061 33852 13519 4798 36354Massachusetts 13786 4981 36843 14021 5004 37634 11603 4541 30098New Jersey 13660 5035 36245 13948 5112 37086 12817 4622 34278New Mexico 11175 3574 31079 11588 3744 32130 7899 2578 21832New York 13277 5004 34942 13773 5093 36502 11963 4543 31392Seattle-Puget Sound 14028 4679 38507 14424 4622 40094 12489 4183 34240Utah 11436 3862 31269 11561 3866 31711 7986 - 22637

SEER 9 Areasb 13137 4607 35472 13429 4641 36441 12770 4473 34498SEER 13 Areasb 12749 4501 34348 13088 4511 35547 12611 4375 34175SEER 18 Areasb 12680 4432 34278 12913 4422 35147 12727 4449 34405SEER 21 Areasb 12849 4556 34564 13126 4563 35550 12480 4473 33447

Table 420Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Death Ratesa 2013-2017

California 1957 419 5982 2042 410 6314 2902 803 8398Greater Bay Area 1743 356 5377 1912 346 6011 2571 764 7303San Francisco-Oakland 1777 374 5450 1915 338 6043 2567 818 7146San Jose-Monterey 1679 324 5228 1906 360 5952 2604 - 8212

Los Angeles 1976 453 5965 1993 418 6115 3015 853 8676Greater California 2023 426 6203 2097 425 6474 2945 769 8645

Connecticut 1785 410 5384 1782 394 5416 2029 609 5749Detroit 2200 468 6737 2042 430 6261 2880 640 8745Georgia 2200 498 6657 1970 390 6107 2831 717 8367Atlanta 2250 522 6772 1869 377 5775 2983 720 8908Rural Georgia 2411 - 8049 1998 - 7001 3123 - 10011Greater Georgia 2168 487 6569 2004 399 6206 2714 719 7936

Hawaii 1609 321 4983 2018 - 6426 - - -Idaho 2159 396 6777 2194 399 6893 - - -Iowa 1867 370 5784 1867 363 5806 1976 - 5396Kentucky 2119 486 6393 2104 473 6377 2507 731 7157Louisiana 2308 530 6966 1955 377 6087 3213 851 9397Massachusetts 1780 386 5431 1825 403 5548 1832 377 5641New Jersey 2131 438 6564 2086 392 6523 2910 788 8466New Mexico 1929 389 5960 2023 414 6236 1752 - 4850New York 1928 417 5887 1933 376 6009 2300 633 6666Seattle-Puget Sound 1991 345 6301 2064 335 6590 2169 585 6316Utah 2010 400 6228 2025 394 6297 - - -

SEER 9 Areasb 1947 406 5981 1942 375 6045 2711 688 8009SEER 13 Areasb 1940 412 5943 1952 384 6058 2786 718 8200SEER 18 Areasb 2026 433 6198 2017 401 6248 2857 749 8376SEER 21 Areasb 1995 427 6101 1991 397 6165 2675 707 7827

Total US 2031 433 6215 1982 397 6132 2762 724 8099

Table 421Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 2794 1035 7401 2693 989 7155 2853 795 8241Greater Bay Area 3251 1326 8290 3106 1267 7922 2944 873 8366San Francisco-Oakland 3502 1438 8907 3378 1372 8631 3035 876 8688San Jose-Monterey 2775 1124 7098 2631 1085 6680 2296 - 6077

Los Angeles 2686 968 7185 2561 905 6897 2946 848 8439Greater California 2682 960 7190 2633 949 7042 2699 717 7887

Connecticut 4343 2110 10190 4380 2185 10128 3769 1447 9849Detroit 3565 1435 9142 3596 1583 8866 3713 1081 10606Georgia 2885 1087 7593 2785 1091 7221 3219 1052 8893Atlanta 3399 1312 8866 3469 1416 8845 3515 1187 9610Rural Georgia 2756 945 7498 2779 - 7297 2811 - 8046Greater Georgia 2611 944 6976 2524 951 6644 2963 919 8317

Hawaii 3530 1327 9299 2776 1119 7116 - - -Idaho 2338 1025 5777 2351 1045 5770 - - -Iowa 2811 1100 7293 2817 1122 7253 3067 - 8861Kentucky 2614 991 6866 2593 1006 6746 3028 893 8620Louisiana 2534 835 6983 2433 833 6622 2867 846 8160Massachusetts 3962 1871 9437 4023 1922 9524 3427 1384 8778New Jersey 4115 1902 9911 4192 1971 10008 3418 1273 9036New Mexico 2054 718 5552 2123 750 5719 1520 - -New York 4235 1976 10151 4352 2081 10300 3646 1323 9731Seattle-Puget Sound 3558 1366 9298 3469 1281 9198 3822 1223 10629Utah 2262 874 5898 2284 895 5920 - - -

SEER 9 Areasb 3346 1362 8541 3281 1366 8296 3535 1143 9798SEER 13 Areasb 3157 1251 8148 3081 1236 7914 3388 1080 9433SEER 18 Areasb 3050 1197 7902 2990 1190 7706 3179 1010 8857SEER 21 Areasb 3300 1365 8366 3275 1379 8242 3302 1099 9071

Table 422Cancer of the Female Breast (In Situ)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Death Ratesa 2013-2017

California 1957 419 5982 2042 410 6314 2902 803 8398Greater Bay Area 1743 356 5377 1912 346 6011 2571 764 7303San Francisco-Oakland 1777 374 5450 1915 338 6043 2567 818 7146San Jose-Monterey 1679 324 5228 1906 360 5952 2604 - 8212

Los Angeles 1976 453 5965 1993 418 6115 3015 853 8676Greater California 2023 426 6203 2097 425 6474 2945 769 8645

Connecticut 1785 410 5384 1782 394 5416 2029 609 5749Detroit 2200 468 6737 2042 430 6261 2880 640 8745Georgia 2200 498 6657 1970 390 6107 2831 717 8367Atlanta 2250 522 6772 1869 377 5775 2983 720 8908Rural Georgia 2411 - 8049 1998 - 7001 3123 - 10011Greater Georgia 2168 487 6569 2004 399 6206 2714 719 7936

Hawaii 1609 321 4983 2018 - 6426 - - -Idaho 2159 396 6777 2194 399 6893 - - -Iowa 1867 370 5784 1867 363 5806 1976 - 5396Kentucky 2119 486 6393 2104 473 6377 2507 731 7157Louisiana 2308 530 6966 1955 377 6087 3213 851 9397Massachusetts 1780 386 5431 1825 403 5548 1832 377 5641New Jersey 2131 438 6564 2086 392 6523 2910 788 8466New Mexico 1929 389 5960 2023 414 6236 1752 - 4850New York 1928 417 5887 1933 376 6009 2300 633 6666Seattle-Puget Sound 1991 345 6301 2064 335 6590 2169 585 6316Utah 2010 400 6228 2025 394 6297 - - -

SEER 9 Areasb 1947 406 5981 1942 375 6045 2711 688 8009SEER 13 Areasb 1940 412 5943 1952 384 6058 2786 718 8200SEER 18 Areasb 2026 433 6198 2017 401 6248 2857 749 8376SEER 21 Areasb 1995 427 6101 1991 397 6165 2675 707 7827

Total US 2031 433 6215 1982 397 6132 2762 724 8099

Table 421Cancer of the Female Breast (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Age

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 2794 1035 7401 2693 989 7155 2853 795 8241Greater Bay Area 3251 1326 8290 3106 1267 7922 2944 873 8366San Francisco-Oakland 3502 1438 8907 3378 1372 8631 3035 876 8688San Jose-Monterey 2775 1124 7098 2631 1085 6680 2296 - 6077

Los Angeles 2686 968 7185 2561 905 6897 2946 848 8439Greater California 2682 960 7190 2633 949 7042 2699 717 7887

Connecticut 4343 2110 10190 4380 2185 10128 3769 1447 9849Detroit 3565 1435 9142 3596 1583 8866 3713 1081 10606Georgia 2885 1087 7593 2785 1091 7221 3219 1052 8893Atlanta 3399 1312 8866 3469 1416 8845 3515 1187 9610Rural Georgia 2756 945 7498 2779 - 7297 2811 - 8046Greater Georgia 2611 944 6976 2524 951 6644 2963 919 8317

Hawaii 3530 1327 9299 2776 1119 7116 - - -Idaho 2338 1025 5777 2351 1045 5770 - - -Iowa 2811 1100 7293 2817 1122 7253 3067 - 8861Kentucky 2614 991 6866 2593 1006 6746 3028 893 8620Louisiana 2534 835 6983 2433 833 6622 2867 846 8160Massachusetts 3962 1871 9437 4023 1922 9524 3427 1384 8778New Jersey 4115 1902 9911 4192 1971 10008 3418 1273 9036New Mexico 2054 718 5552 2123 750 5719 1520 - -New York 4235 1976 10151 4352 2081 10300 3646 1323 9731Seattle-Puget Sound 3558 1366 9298 3469 1281 9198 3822 1223 10629Utah 2262 874 5898 2284 895 5920 - - -

SEER 9 Areasb 3346 1362 8541 3281 1366 8296 3535 1143 9798SEER 13 Areasb 3157 1251 8148 3081 1236 7914 3388 1080 9433SEER 18 Areasb 3050 1197 7902 2990 1190 7706 3179 1010 8857SEER 21 Areasb 3300 1365 8366 3275 1379 8242 3302 1099 9071

Table 422Cancer of the Female Breast (In Situ)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

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ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+ All Ages Ages lt50 Ages 50+

SEER Incidence Ratesa 2013-2017

California 2794 1035 7401 2693 989 7155 2853 795 8241Greater Bay Area 3251 1326 8290 3106 1267 7922 2944 873 8366San Francisco-Oakland 3502 1438 8907 3378 1372 8631 3035 876 8688San Jose-Monterey 2775 1124 7098 2631 1085 6680 2296 - 6077

Los Angeles 2686 968 7185 2561 905 6897 2946 848 8439Greater California 2682 960 7190 2633 949 7042 2699 717 7887

Connecticut 4343 2110 10190 4380 2185 10128 3769 1447 9849Detroit 3565 1435 9142 3596 1583 8866 3713 1081 10606Georgia 2885 1087 7593 2785 1091 7221 3219 1052 8893Atlanta 3399 1312 8866 3469 1416 8845 3515 1187 9610Rural Georgia 2756 945 7498 2779 - 7297 2811 - 8046Greater Georgia 2611 944 6976 2524 951 6644 2963 919 8317

Hawaii 3530 1327 9299 2776 1119 7116 - - -Idaho 2338 1025 5777 2351 1045 5770 - - -Iowa 2811 1100 7293 2817 1122 7253 3067 - 8861Kentucky 2614 991 6866 2593 1006 6746 3028 893 8620Louisiana 2534 835 6983 2433 833 6622 2867 846 8160Massachusetts 3962 1871 9437 4023 1922 9524 3427 1384 8778New Jersey 4115 1902 9911 4192 1971 10008 3418 1273 9036New Mexico 2054 718 5552 2123 750 5719 1520 - -New York 4235 1976 10151 4352 2081 10300 3646 1323 9731Seattle-Puget Sound 3558 1366 9298 3469 1281 9198 3822 1223 10629Utah 2262 874 5898 2284 895 5920 - - -

SEER 9 Areasb 3346 1362 8541 3281 1366 8296 3535 1143 9798SEER 13 Areasb 3157 1251 8148 3081 1236 7914 3388 1080 9433SEER 18 Areasb 3050 1197 7902 2990 1190 7706 3179 1010 8857SEER 21 Areasb 3300 1365 8366 3275 1379 8242 3302 1099 9071

Table 422Cancer of the Female Breast (In Situ)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Age

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 10 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 2031 005

High Five StatesDC 2662 123 01(0103) 3108c

Mississippi 2352 051 02(0108) 1578c

Louisiana 2308 041 03(0110) 1365c

Oklahoma 2239 044 04(0221) 1026c

Ohio 2227 025 05(0214) 965

Low Five StatesMinnesota 1791 033 47(3850) -1183c

Connecticut 1785 039 48(3851) -1213c

Massachusetts 1780 029 49(4051) -1236c

Vermont 1771 093 50(2551) -1282c

Hawaii 1609 060 51(4551) -2077c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 2144 038 15(0426) 555 Montana 1950 077 31(0950) -398Alaska 1945 114 32(0451) -423 Nebraska 2011 060 25(0844) -098Arizona 1915 031 36(2646) -571 Nevada 2188 053 07(0226) 774Arkansas 2106 048 21(0432) 370 New Hampshire 1889 066 40(2050) -698California 1957 013 30(2638) -366 New Jersey 2131 027 17(0626) 492Colorado 1887 036 41(2748) -707 New Mexico 1929 055 34(2048) -503Connecticut 1785 039 48(3851) -1213c New York 1928 018 35(2842) -505Delaware 2134 083 16(0240) 506 North Carolina 2092 026 23(0928) 302DC 2662 123 01(0103) 3108c North Dakota 1802 093 45(2051) -1127c

Florida 1912 017 37(3044) -584 Ohio 2227 025 05(0214) 965Georgia 2200 028 06(0319) 833 Oklahoma 2239 044 04(0221) 1026c

Hawaii 1609 060 51(4551) -2077c Oregon 2004 040 27(1741) -132Idaho 2159 069 11(0231) 631 Pennsylvania 2125 022 19(0725) 462Illinois 2129 023 18(0725) 485 Rhode Island 1798 073 46(2651) -1146c

Indiana 2095 033 22(0829) 316 South Carolina 2151 038 13(0426) 591Iowa 1867 044 42(2750) -809 South Dakota 1909 087 38(0851) -601Kansas 1943 047 33(2146) -434 Tennessee 2176 033 10(0423) 714Kentucky 2119 040 20(0428) 431 Texas 1986 017 29(2436) -223Louisiana 2308 041 03(0110) 1365c Utah 2010 056 26(1043) -101Maine 1858 063 43(2450) -852 Vermont 1771 093 50(2551) -1282c

Maryland 2177 035 09(0324) 720 Virginia 2154 029 12(0424) 606Massachusetts 1780 029 49(4051) -1236c Washington 1993 031 28(2240) -188Michigan 2071 026 24(1229) 197 West Virginia 2179 060 08(0228) 728Minnesota 1791 033 47(3850) -1183c Wisconsin 1897 033 39(2847) -660Mississippi 2352 051 02(0108) 1578c Wyoming 1830 105 44(1351) -988Missouri 2146 034 14(0426) 567

Table 423Cancer of the Female Breast (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 1038322 802756 618582 487569 310008 3257238 340094 3597331

Males 8131 5042 2792 2007 1109 19080 987 20067Females 1030192 797714 615791 485562 308899 3238158 339106 3577264

White Both Sexes 858031 679619 535262 429063 274298 2776273 302447 3062980Males 6500 4289 2354 1679 918 15740 + +Females 851531 675330 532908 427384 273381 2760533 302447 3062980

Black Both Sexes 115147 78960 54273 37362 23743 309485 28817 335782Males 1283 573 329 239 96 2520 + +Females 113864 78387 53944 37124 23647 306966 28817 335782

Asian Both Sexes 49457 34063 23166 16432 9005 132123 + +Pacific Males 254 103 69 35 30 492 + +Islander Females 49202 33960 23097 16397 8975 131631 + +

Hispanic Both Sexes 86858 58758 40282 27023 15667 228587 + +Males 475 227 140 65 29 936 + +Females 86383 58530 40142 26957 15638 227651 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 10050 00000 00001 00071 00960 05147 13812 25724 41260 48849 08375

Males 00120 - - - 00008 00026 00106 00281 00676 01024 00112Females 19685 00001 00001 00146 01920 10183 26916 48744 75215 78628 15400

White Both Sexes 10971 00001 00001 00072 00931 05157 13985 26249 42635 50495 08556Males 00126 - - - 00006 00022 00093 00268 00672 01031 00108Females 21628 00001 00002 00148 01888 10351 27559 50320 78513 81852 15891

Black Both Sexes 06795 - - 00071 01091 04963 12734 23191 34736 40839 07445Males 00115 - - - 00011 00045 00197 00428 00885 01121 00151Females 12960 - - 00143 02089 09320 23657 41381 58406 60672 12856

Asian Both Sexes 06336 - - 00061 00906 05061 12848 21237 27688 28808 06486Pacific Males 00049 - - - 00016 00018 00063 00151 00296 00533 00059Islander Females 12125 - - 00119 01716 09522 23923 38225 49613 47243 11674

Hispanic Both Sexes 03932 - 00001 00058 00742 03744 09760 18407 27609 29562 05753Males 00032 - - - 00010 00024 00043 00141 00332 00573 00059Females 07914 - 00002 00121 01539 07567 19377 34629 48629 47556 10565

Table 424Cancer of the Breast (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

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50

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1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

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20

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1975 1985 1995 2005 20170

5

10

15

20

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1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

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500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Epidermoid carcinoma includes squamous basal and transitional cell carcinomase Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574 8576

8940-8941f Other adenocarcinomas include histologies 8141-8147 8160-8162 8180-8210 8212-8221 8250-8259 8261-8479 8483-8499

8501-8502 8505-8507 8514 8521 8525-8529 8531-8539 8544-8551 8560 8570-8574 8576 8940-8941g Other specific carcinomas include histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671h Other includes histologies 8012-8015 8030-8046 8150-8155 8170-8175 8230-8249 8508 8561-8562 8575 8580-8671- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 439817 995 347207 995 50670 993 35197 994 1595 993 49122 992Epidermoid carcinomad 199 00 161 00 24 00 - - - - 22 00(8051-8131)

Adenocarcinomae 432117 977 341551 979 49283 966 34677 979 1565 974 48132 972Adenocarcinoma NOS (8140) 2718 06 2115 06 362 07 178 05 17 11 300 06Infiltrating duct 319963 724 249944 716 37775 740 27256 769 1231 767 36663 740carcinoma (8500)Lobular carcinoma NOS 43930 99 37210 107 3917 77 2246 63 112 70 3952 80(8520)

Inflammatory 865 02 661 02 140 03 52 01 - - 159 03adenocarcinoma (8530)Infiltrating duct mixed 43090 97 35105 101 4318 85 3030 86 131 82 4782 97and infiltrating lobularmixed (8522-8524)Mucinous adenocarcinoma 8215 19 6146 18 1092 21 871 25 20 12 887 18(84808482)

Mucin-producing 65 00 49 00 - - - - - - - -adenocarcinoma (8481)Tubular adenocarcinoma 2187 05 1941 06 144 03 69 02 - - 161 03(8211)

Papillary adenocarcinoma 3326 08 2392 07 522 10 330 09 18 11 393 08(8050826085038504)Paget disease (8540-8543) 1328 03 1065 03 146 03 90 03 - - 116 02Other adenocarcinomasf 6430 15 4923 14 858 17 549 15 20 12 709 14

Other specific carcinomasg 3354 08 2469 07 625 12 223 06 - - 444 09Medullary adenocarcinoma 689 02 453 01 178 03 49 01 - - 150 03(8510-8513)

Otherh 2665 06 2016 06 447 09 174 05 - - 294 06Unspecified Carcinoma NOS 4147 09 3026 09 738 14 284 08 21 13 524 11(8010-80118020-8022)

Table 425

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

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30

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1975 1985 1995 2005 20170

50

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150

200

250

300

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400

450

1975 1985 1995 2005 20170

50

100

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200

250

300

350

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450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

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30

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1975 1985 1995 2005 20170

5

10

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1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

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500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

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1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Other sarcomas include histologies 8680-8713 8800-8921 9040-9044 9127-9136 9150-9169 9171-9252 9370-9373 9540-9582e Other includes histologies 8720-8790 8930-8936 8950-9019 9021-9030 9060-9110 9260-9365 9380-9539f Total includes carcinoma cases from the previous page- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Sarcoma and other soft tissue 445 01 343 01 63 01 32 01 - - 55 01tumors (8680-87138800-89219040-90449120-91369150-92529370-93739540-9582)

Hemangiosarcomas 252 01 213 01 24 00 - - - - 24 00(9120-91269170)

Other sarcomasd 193 00 130 00 39 01 19 01 - - 31 01

Other specific types 911 02 636 02 115 02 129 04 - - 198 04(8720-87908930-89368950-90309060-91109260-93659380-9539)

Phyllodes tumor malignant 784 02 541 02 91 02 123 03 - - 175 04(9020)

Othere 127 00 95 00 24 00 - - - - 23 00

Unspecified (8000-8005) 1005 02 702 02 172 03 63 02 - - 153 03

Totalf 442178 1000 348888 1000 51020 1000 35421 1000 1606 1000 49528 1000

Table 425 - continued

Cancer of the Female Breast (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Estimates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesc Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registryd Adenocarcinoma includes histologies 80508140-81478160-81628180-822182308250-850785148520-855185608570-857485768940-8941e Ductal carcinoma includes histologies 8201 8230 8401 8500-8507 8523f CIS = Carcinoma in situg Other adenocarcinomas include 8050 8141-8147 8160-8162 8180-8200 8202-8221 8250-8400 8402-8499 8514 8525-8551 8560

8570-8574 8576 8940-8941h Other histologies include 8000-8049 8051-8139 8148-8159 8163-8179 8222-8229 8231-8249 8508-8513 8515-8519 8552-8559

8561-8569 8575 8577-8939 8942-9989- Statistic not shown due to fewer than 16 cases during the time period

AsianPacific American IndianAll Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Adenocarcinomad 112659 999 85269 999 13833 999 11385 999 346 997 12906 999Adenocarcinoma in situ NOS - - - - - - - - - - - -(81402)

Ductal carcinoma in situ e 91842 815 68384 801 11814 853 9993 877 305 879 10610 821Cribiform carcinoma in situ 10106 90 7450 87 1300 94 1171 103 24 69 1139 88(82012)

Ductal carcinoma in situ 8130 72 6253 73 890 64 866 76 28 81 791 61solid type(82302)

Ductal carcinoma in situ 24909 221 18910 222 3041 220 2411 212 101 291 2864 222NOS (85002)

Comedocarcinoma in situ 8251 73 6249 73 943 68 930 82 31 89 907 70(85012)

Ductal carcinoma in situ 1650 15 1072 13 342 25 196 17 - - 221 17papillary(85032)

Noninfiltrating intracystic 362 03 231 03 59 04 64 06 - - 37 03carcinoma(85042)

Ductal carcinoma in situ 1502 13 1146 13 211 15 122 11 - - 170 13micropapillary(85072)

Intraductal with other types 36670 325 26882 315 5007 362 4187 367 112 323 4457 345of carcinoma in situ(85232)

Lobular carcinoma in situ 16631 147 13576 159 1549 112 1042 91 33 95 1840 142(85202-85212 85242)Lobular carcinoma in situ 16617 147 13569 159 1543 111 1041 91 33 95 1839 142NOS (85202)

Lobular CISf with other CISf - - - - - - - - - - - -(85242)

Intraductal and lobular 3519 31 2822 33 387 28 266 23 - - 373 29in situ carcinoma (85222)

Other adenocarcinomasg 661 06 483 06 82 06 83 07 - - 83 06

Other in situ histologiesh 98 01 66 01 - - - - - - - -

Total 112757 1000 85335 1000 13847 1000 11396 1000 347 1000 12917 1000

Table 426

Cancer of the Female Breast(In Situ)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2013-2017Females by Race

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

20

40

60

80

100

120

140

160

1975 1985 1995 2005 20170

20

40

60

80

100

120

140

160

1975 1985 1995 2005 2017

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Race

a

Figure 41

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC2011-17 = -13

SEER Incidence APCsDelay Adj 1988-17 = 03Observed 1988-17 = 03

US Mortality APC1993-17 = -15

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

10

20

30

40

50

1975 1985 1995 2005 20170

10

20

30

40

50

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 20170

50

100

150

200

250

300

350

400

450

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Female Breast by Age and Race

a

Figure 42

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Ages lt50 Black Ages lt50 White Ages 50+ Black Ages 50+Rate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1994-17 = 03Observed 1994-17 = 03

US Mortality APC2005-17 = -14

SEER Incidence APCsDelay Adj 1990-17 = -01Observed 1991-17 = -01

US Mortality APC1989-17 = -22

SEER Incidence APCsDelay Adj 2004-17 = 03Observed 2004-17 = 02

US Mortality APC1998-17 = -17

SEER Incidence APCsDelay Adj 1992-17 = 04Observed 1992-17 = 03

US Mortality APC1993-17 = -13

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20170

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2017

Observed IncidenceObserved Incidence

SEER Observed Incidence RatesCancer of the Female Breast (In Situ) by Race

a

Figure 43

Source SEER 9 areasRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White BlackRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

25

50

75

100

125

150

1975 1985 1995 2005 20170

25

50

75

100

125

150

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Female Breast

Figure 44

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 45

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

All Races FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 46

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

White FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

100

200

300

400

500

1975 1980 1985 1990 1995 2000 2005 2010 20171

10

100

1000

1975 1980 1985 1990 1995 2000 2005 2010 2017

Ages 20-49

Malig Ages 20-49

Ages 50+

Malig Ages 50+

Figure 47

Cancer of Female Breast Incidence Rates 1975-2017In situ vs Malignant by Age

Black FemalesIn Situ

Source SEER 9 areas Rates are per 100000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000 (linear scale) Rate per 100000 (log scale)

Year of Diagnosis Year of Diagnosis

In Situ

In Situ

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

20

40

60

80

100

120

140

160

1975 1980 1985 1990 1995 2000 2005 2010 2017

Delay-Adjusted SEER Incidence White

Delay-Adjusted SEER Incidence Black

US Mortality White

US Mortality Black

Figure 48

Cancer of the Breast Delay-Adjusted SEER Incidence amp US Mortality

White Females vs Black Females1975-2017

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of DiagnosisDeath

Delay-Adjusted SEER Incidence

US Mortality

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

0

10

20

30

40

50

1975 1980 1985 1990 1995 2000 2005 2010 2017

Lung amp Bronchus White

Lung amp Bronchus Black

Breast White

Breast Black

US Death Rates for Cancer of the Breast and Cancer of the Lung and BronchusWhite Females vs Black Females

1975-2017

Figure 49

Source US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103) Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020National Cancer Institute

Rate per 100000

Year of Death

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival

Figure 410

Cancer of the Female Breast5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

• Trends in SEER Incidence and US Mortality Females All Ages
• Trends in SEER Incidence and US Mortality Females Ages lt50
• Trends in SEER Incidence and US Mortality Females Ages 50+
• Trends in SEER Incidence Females (In Situ Cases)
• Annual Incidence Rates by Sex
• Annual Death Rates by Sex
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Annual Incidence Rates (In Situ Cases)
• Incidence and Mortality Rates by Age
• Incidence Rates by Age (In Situ Cases)
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis All Ages
• Relative Survival by Year of Diagnosis Ages lt50
• Relative Survival by Year of Diagnosis Ages 50+
• Risk of DevelopingDying
• Rates and Trends by RaceEthnicity
• Rates and Trends by RaceEthnicity (In Situ Cases)
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Case Distribution by Histology (In Situ Cases)
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Age and Race
• Graph - SEER Incidence and Delay Adjusted Incidence by Race (In Situ cases)
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates In Situ vs Malignant All Races
• Graph - SEER Incidence Rates In Situ vs Malignant White
• Graph - SEER Incidence Rates In Situ vs Malignant Black
• Graph - SEER Delay Adjusted Incidence and US Mortality White vs Black
• Graph - US Mortality Comparison White vs Black Females (Breast Lung and Bronchus)
• Graph - 5-Year SEER Conditional Relative Survival