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8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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Tanda Klinik Fase Diensefalik.
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Tanda Klinik Fase Diensefalik.
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Tanda Klinik Fase Midbrain Pons Atas.
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Tanda Klinik Herniasi Unkus Fase Dini N. III
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Tanda Klinik Herniasi Unkus Fase Lanjut N.III
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Tanda Klinik Fase Midbrain Pons Bawa
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Cardiac death: Heartbeat and breathing stop
Brain death:
Irreversible cessation of all functions of theentire brain, including the brain stem
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First introduced in a 1968 report authored b aspecial committee of the Harvard !edical "chool
#dopted in 198$, %ith modi&cations, b the'resident(s Commission for the "tud of )thical'resident(s Commission for the "tud of )thical
'roblems in !edicine and Biomedical *esearch'roblems in !edicine and Biomedical *esearch,as a recommendation for state legislatures andcourts
+he brain death standard %as also emploed in
the model legislation -no%n as the .niform.niform/etermination of /eath #ct/etermination of /eath #ct, %hich has beenenacted b a large number of 0urisdictions andthe standard has been endorsed b theinuential #merican Bar #ssociation2
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12 Clinical or radiographic evidence of anacute catastrophic cerebral eventconsistent %3 d4 of brain death
52 )4clusion of conditions that confoundclinical evidence i2e27metabolic
2 Con&rmation of absence of druginto4ication or poisoning
#lso barbiturates, !B;s
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Cerebral motor response to pain "upra7orbital ridge, the nail beds, trape>ius
!otor responses ma occur spontaneouslduring apnea testing spinal ree4es
"pinal ree4 responses occur more often inoung
If pt had !B, then test %3 train7of7four
"pinal arcs are intact?
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*ound, oval, or irregularl shaped !idsi>e e, the
light ree4 remains intact onl in the absence ofbrain death I@ atropine does not mar-edl aAect response 'araltics do not aAect pupillar si>e +opical administration of drugs and ee trauma
ma inuence pupillar si>e and reactivit 're7e4isting ocular anatomic abnormalities ma
also confound pupillar assessment in brain death
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culocephalic ree4 doll;s ees
@estibulo7ocular cold caloric test
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culocephalic ree4 *apidl turn the head 9$D on both sides
ormal response deviation of the ees tothe opposite side of head turning
Brain death oculocephalic ree4es areabsent no /oll;s ees no ee movement inresponse to head movement
ot Barbie, but old fashioned tpe dolls 'ainted vs2 %ooden ees in porcelain heads
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http://images.google.com/imgres?imgurl=http://telemedicine.orbis.org/data/1/rec_imgs/57_9.jpg&imgrefurl=http://telemedicine.orbis.org/bins/volume_page.asp?cid=1-3-4-14&h=115&w=181&sz=8&tbnid=MQ3goRdz9I4J:&tbnh=60&tbnw=94&start=4&prev=/images?q=%22oculocephalic%22&hl=en&lr=&sa=G
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)levate the HB $D
Irrigate both tmpanic membranes %ithiced %ater
bserve pt for 1 minute after each earirrigation, %ith a E minute %ait bet%eentesting of each ear
Facial trauma involving the auditor canal and
petrous bone can also inhibit these ree4es
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stagmus both ees slo% to%ard cold,fast to midline ot comatose
Both ees tonicall deviate to%ard cold%ater Coma %ith intact brainstem
!ovement onl of ee on side of stimulus
Internuclear ophthalmoplegia "uggests brainstem structural lesion
o ee movement Brainstem in0ur 3 death
http://www.fpnotebook.com/NEU90.htmhttp://www.fpnotebook.com/NEU160.htmhttp://www.fpnotebook.com/NEU160.htmhttp://www.fpnotebook.com/NEU90.htm
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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Corneal ree4es are absent in brain death Corneal ree4es 7 tested b using a cotton7
tipped s%ab
rimacing in response to pain can be testedb appling deep pressure to the nail beds,supra7orbital ridge, +!G, or s%ab in nose
"evere facial trauma can inhibit interpretationof facial brain stem ree4es
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Both gag and cough ree4es are absentin patients %ith brain death ag ree4 can be evaluated b stimulating
the posterior pharn4 %ith a tongue blade, butthe results can be dicult to evaluate in orallintubated patients
Cough ree4 can be tested b using )++suctioning, past end of )++
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'aC5 levels greater than 6$ mmHg, 5$mmHg over baseline
+echniJue: 're7o4genate %ith 1$$K o4gen several min
#llo% baseline 'aC5 to be L
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)) $ minutes
< vessel angiograph
Cerebral blood o% perfusion scan
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http://images.google.com/imgres?imgurl=http://pedsccm.wustl.edu/All-Net/media/gif/neurogif/trauma/cpscanbd.jpg&imgrefurl=http://pedsccm.wustl.edu/All-Net/english/neurpage/trauma/head-5.htm&h=249&w=538&sz=16&tbnid=oBGKQkhMfkYJ:&tbnh=60&tbnw=129&start=3&prev=/images?q=%22cerebral+perfusion+scan%22&hl=en&lr=&sa=N
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ecessar to repeat the clinical e4amination afteran Mappropriate; observation period has passed
Con&rmator )) unless it is determined thatthere is no blood o% to the brain
Age 7 days to 2 monthsAge 7 days to 2 months +%o e4aminations
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12 Clinical or radiographic evidence of anacute catastrophic cerebral eventconsistent %3 d4 of brain death
52 )4clusion of conditions that confoundclinical evidence i2e27metabolic
2 Con&rmation of absence of druginto4ication or poisoning
#lso barbiturates, !B;s
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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Cerebral motor response to pain "upra7orbital ridge, the nail beds, trape>ius
!otor responses ma occur spontaneouslduring apnea testing spinal ree4es
"pinal ree4 responses occur more often inoung
If pt had !B, then test %3 train7of7four
"pinal arcs are intact?
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
58/103
*ound, oval, or irregularl shaped !idsi>e e, the
light ree4 remains intact onl in the absence ofbrain death I@ atropine does not mar-edl aAect response 'araltics do not aAect pupillar si>e +opical administration of drugs and ee trauma
ma inuence pupillar si>e and reactivit 're7e4isting ocular anatomic abnormalities ma
also confound pupillar assessment in brain death
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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culocephalic ree4 doll;s ees
@estibulo7ocular cold caloric test
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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culocephalic ree4 *apidl turn the head 9$D on both sides
ormal response deviation of the ees tothe opposite side of head turning
Brain death oculocephalic ree4es areabsent no /oll;s ees no ee movement inresponse to head movement
ot Barbie, but old fashioned tpe dolls 'ainted vs2 %ooden ees in porcelain heads
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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http://images.google.com/imgres?imgurl=http://telemedicine.orbis.org/data/1/rec_imgs/57_9.jpg&imgrefurl=http://telemedicine.orbis.org/bins/volume_page.asp?cid=1-3-4-14&h=115&w=181&sz=8&tbnid=MQ3goRdz9I4J:&tbnh=60&tbnw=94&start=4&prev=/images?q=%22oculocephalic%22&hl=en&lr=&sa=G
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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)levate the HB $D
Irrigate both tmpanic membranes %ithiced %ater
bserve pt for 1 minute after each earirrigation, %ith a E minute %ait bet%eentesting of each ear
Facial trauma involving the auditor canal andpetrous bone can also inhibit these ree4es
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
63/103
stagmus both ees slo% to%ard cold,fast to midline ot comatose
Both ees tonicall deviate to%ard cold%ater Coma %ith intact brainstem
!ovement onl of ee on side of stimulus Internuclear ophthalmoplegia "uggests brainstem structural lesion
o ee movement Brainstem in0ur 3 death
http://www.fpnotebook.com/NEU90.htmhttp://www.fpnotebook.com/NEU160.htmhttp://www.fpnotebook.com/NEU160.htmhttp://www.fpnotebook.com/NEU90.htm
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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Corneal ree4es are absent in brain death Corneal ree4es 7 tested b using a cotton7
tipped s%ab
rimacing in response to pain can be testedb appling deep pressure to the nail beds,supra7orbital ridge, +!G, or s%ab in nose
"evere facial trauma can inhibit interpretationof facial brain stem ree4es
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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Both gag and cough ree4es are absentin patients %ith brain death ag ree4 can be evaluated b stimulating
the posterior pharn4 %ith a tongue blade, butthe results can be dicult to evaluate in orallintubated patients
Cough ree4 can be tested b using )++suctioning, past end of )++
8/18/2019 Mekanisme Gangguan Kesadaran Power Point
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)) $ minutes
< vessel angiograph
Cerebral blood o% perfusion scan
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#bsent Cerebral Function
#bsent Brainstem Function
#pnea
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Cerebral Corte4
Brain "tem
*eticular#ctivating"stem
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Cognition
@oluntar
!ovement "ensation
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Midbrain
Cranial Nerve III
pupillary function
eye movement
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Pons
Cranial Nerves IV, V, VI
conjugate eye movement
corneal reflex
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Medulla
Cranial Nerves IX, X
Pharyngeal (Gag) eflex
!racheal (Cough) eflex
espiration
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*eceives multiple
sensor inputs
!ediates
%a-efulness
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NormalCere"ral #noxia
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Normal Cere"ral $emorrhage
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Normal%u"arachnoi& $emorrhage
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Normal !rauma
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Normal'eningitis
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Neuronal Injury
ecrease& Intracranial
loo& *lo+
Neuronal %+elling
Increase& Intracranial
Pressure
ICP'#P is
incompati"le
+ith life
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'ersistent @egetative "tate
Noc-ed7in "ndrome
!inimall *esponsive "tate
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ormal "leep7Oa-e Ccles
o *esponse to )nvironmental "timuli
/iAuse Brain In0ur %ith 'reservation
of Brain "tem Function
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!entral Pontine Infar"t
Complete Paralysis
Preserve& Consciousness
Preserve& -ye 'ovement
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/iAuse or !ulti7Focal Brain In0ur
'reserved Brain "tem Function
@ariable Interaction %ith
)nvironmental "timuli
%tatic -ncephalopathy
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Clinical 'rereJuisites:
Pno%n Irreversible Cause
)4clusion of 'otentiall *eversible Conditions /rug Into4ication or 'oisoning
)lectrolte or #cid7Base Imbalance )ndocrine /isturbances
Core Bod temperature = 5D C
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Coma
#bsent Brain "tem *ee4es
#pnea
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o *esponse to o4ious "timuli
ail Bed 'ressure
"ternal *ub
"upra7rbital *idge 'ressure
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'upillar *ee4
)e !ovements
Facial "ensation and !otor *esponse
'harngeal ag *ee4
+racheal Cough *ee4
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Pupils &ilate& +ith no constriction to "right light
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.cculo/Cephalic esponse
0oll1s -yes 'aneuver2
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.culo/Vesti"ular esponse
0Col& Caloric !esting2
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Corneal *ee4
Ga% *ee4
rimace to "upraorbital or
+emporo7!andibular 'ressure
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'rereJuisites
Core Bod +emperature = 5D C
"stolic Blood 'ressure 9$ mmHg
ormal )lectroltes
ormal 'C5
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12 're74genation 1$$K 4gen via +racheal Cannula
'5 5$$ mm Hg
52 !onitor 'C5 and '5 %ith pulse o4imetr
2 /isconnect @entilator
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Facial +rauma
'upillar #bnormalities
C" "edatives or euromuscularBloc-ers
Hepatic Failure
'ulmonar /isease
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##
$
Normal -lectrocere"ral %ilence
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Cerebral#ngiograph
Normal No Intracranial *lo+
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+echnetium799 Isotope Brain "can
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!*7 #ngiograph
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!ranscranial
3ltrasonography
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"omatosensor )vo-ed 'otentials