Prevention of early-onset GBS disease CDC, 2010. Prof. Aboubakr
Elnashar Benha university, Egypt Aboubar Elnashar
Incidence Asymptomatic carriage of GBS: Common. 10-30% of all
pregnant women Organism Streptococcus agalactiae: Gram-positive
Colonize the lower GIT & Spread to the genitourinary tract
Aboubar Elnashar
Found in pairs or chains 6 groups: A, B, C, D, F, and G by
antibodies that recognize surface antigens (Streptococcus
fluorescent antibody stain (digitally colorized). The most
important: A, B and D. 3 types of hemolysis after growth of
streptococci on blood agar. Alpha: partial hemolysis Beta: complete
clearing Gamma: no lysis. Group A and group B are beta hemolytic
Aboubar Elnashar
Neonatal sepsis USA: GBS is the leading cause of neonatal
bacterial sepsis UK: GBS is the most frequent cause of neonatal
severe early onset infection (0.5/1000 births). There is
controversy about its prevention Aboubar Elnashar
