AIHANYOTO WIDYO ASTOROHEMATOLOGI ONKOLOGIRSGS

AIHACharacterized by shortened red blood cell survival and autoantibodies directed against red blood cell antigens. 1 in 75.000-80.000 per yearWarm AIHA 60-70% of all AIHA50% Warm AIHA are idiopathic or primary

CLASIFICATION AIHA

PATHOPHYSIOLOGYTwo mechanism immune mediated red blood cell destruction :Extravascular hemolysisIntravascular hemolysis

Extravascular Hemolysis

Intravascular Hemolysis

Clinical feanturesFatigue, weakness, malaiseDizzinesFeverBack painDydpnea on exertionJaundiceDiscolored urinePallor

Physical ExaminationJaundice and or pallorHepatosplenomegalyThromboembolism

LaboratoryAnemiaElevated reticulosytesElevated BillirubinElevated LDHElevated urobilinCoombs test positive

PERIPHERAL BOOD SMEAR

TratmentCorticosteroid 60mg-100mg/day for 1-3 weekSplenectomy with low dose prednison (