2. Cardiovascular diseases take more lives inRussia than other
mortality causes combined020040060080010001200Infections
RespiratorydiseasesDigestive diseases External causes Cancer
Cardio- vasculardiseasesMortalityin2011.,thousandsMortality causes
in Russia 3. Coronary stents decrease mortality fromcoronary artery
disease andacute coronary syndrome Coronary stent opens the
narrowed vessel and restoresnormal blood flow Coronary stenting
reduce hospital mortality in patients withacute coronary syndrome
by 75% 4. In coronary stenting, Russia lags behind0102030405060USA
EU27 RussiaCoronary stentsannual use per 10000 More than 1.5
millioncoronary stents used inUSA annually. About 1 million
coronarystents used in EU. Only 77 thousand coronarystents used in
Russia. 5. Butcoronary stents could be betterBare-metal stents and
drug-elutingstents with metal frames savelives, but have their
owndisadvantages Restenosis Several years of
anti-clottingmedication Metal burden in the body 6. The 4th
revolution in angioplasty:bioresorbable stents Leave a naturally
healed vesselwithout permanent metallicimplant, allowing normal
vasomotionand late expansive remodeling. Minimize chronic
inflammatoryeffects of coating and metallicplatform, potentially
shortening theduration of dual anti-platelet therapy Facilitate
re-intervention (PCI andCABG) late reexpansion possible , nojailed
sidebranches and no fullmetal jacket. 7. Biosten LLC: developing
bioresorbable stentsof the next generation Identifying
polymercomposition with desiredresorption rate (in-vivo) Making
polymer tubeswith certain mechanicalproperties Laser cutting stents
frompolymer tubes 8. Biosten results: We developed and demonstrated
biodegradable stent prototypesas a proof of project concept.
Technology is patented and patent pending. 9. Stent prototype
deployment in vessel model 10. Biosten results:
Evaluatedbiocompatibility, cytotoxicity, andbiodegradation Formed a
project team that focuses oncommercialization and sustainabilityof
the R&D projectContacts:Dr. Oksana Manzenyuk, Project
manager,Biosten LLC , [email protected]
