BHOLE NATH, LecturerBHOLE NATH, Lecturer

Dept. of PharmacyDept. of PharmacyLINCOLN UNIVERSITY COLLEGE LINCOLN UNIVERSITY COLLEGE

MALAYSIAMALAYSIA

1. Deliver oxygen to the cells1. Deliver oxygen to the cells

2.To eliminate carbon 2.To eliminate carbon

dioxide from the bodydioxide from the body

3.To regulate the pH of 3.To regulate the pH of

the bloodthe blood

VENTILATION Movement of air to and from the lungs

DISTRIBUTION Air entering lungs are distributed to all parts including the alveoli

DIFFUSION Oxygen from the inspired air diffuses through the walls of the alveoli to the blood capillaries surrounding the alveoli-similarly carbon dioxide diffuses in opposite

direction PERFUSION Blood with high concentrations of carbon dioxide and

low in oxygen is pumped to the pulmonary arteries by the right ventricle and after diffusion, the arterial blood is returned to the left atrium by the pulmonary veins

PASSAGE OF OXYGEN AND CARBON DIOXIDESOURCE OF OXYGEN – INSPIRED AIRSOURCE OF CARBON DIOXIDE-ALVEOLI-Following diffusion from the blood due to metabolism in the body.

PATHWAY FOR THE GASES:PHARYNXLARYNX-TRACHEABRONCHIBRONCHIOLESALVEOLI

atmosphere

o

oxygen

c

Carbon dioxide

Right heart-arteries Left heart-arteries

Systemic circulation

oxygenCarbon dioxide

COMMON SIGNS AND SYMPTOMS1. COUGH2. WHEEZING3. SHORTNESS OF BREATH-DYSPNOEA4. CYANOSIS5. PAIN AROUND CHEST

Mucosal surface lining respiratory tract

Impulses relayed via vagus

Cough centre in brain

Efferent's

diaphragm glottis muscles of chest and abdomen

COUGH – FORCED EXPIRATION AGAINST A CLOSED GLOTTIS WHICH SUDDENLY OPENS TO EXPEL AIR AND UNWANTED MATERIAL FROM THE RESPIRATORY TRACT

MAY BE VOLUNTARY OR INVOLUNTARY

Mucokinetics are a class of drugs which aid in the clearance of mucous from the airways, lungs, bronchi, and trachea. Such drugs can be further categorized by their mechanism of action.expectorantsmucolytic agentsIn general, clearance ability is hampered by bonding to surfaces (stickiness) and by the viscosity (thickness) of mucous secretions in the lungs. In turn, the viscosity is dependent upon the concentration of mucoprotein in the secretions.

Expectorants and mucolytic agents are different types of medication, yet both intend to promote drainage of mucus from the lungs.

An expectorant (from the Latin expectorare, to expel from the chest) works by signaling the body to increase the amount or hydration of secretions, resulting in more yet clearer secretions and as a byproduct lubricating the irritated respiratory tract. One expectorant guaifenesin is commonly available in many cough syrups. Sometimes the term "expectorant" is incorrectly extended to any cough medicine, since it is a universal component.

A mucolytic agent is an agent which dissolves thick mucus and is usually used to help relieve respiratory difficulties. It does so by dissolving various chemical bonds within secretions, which in turn can lower the viscosity by altering the mucin-containing components.e.g ,Bromohexine, Acetyl Cysteine

A cough medicine (or linctus, when in syrup form) is a medicinal drug used in an attempt to treat coughing and related conditions. For dry coughs, treatment with cough suppressants (antitussives) may be attempted to suppress the body's urge to cough. However, in productive coughs (coughs that produce phlegm), treatment is instead attempted with expectorants (typically guaifenesin, in most commercial medications) in an attempt to loosen mucus from the respiratory tract.

These are the drugs that act in the CNS to the threshold of cough center or act peripherally in the respiratory tract to reduce tussal impulses.

NOTE: It is only for dry unproductive coughs

ANTITUSSIVE/ COUGH SUPPRESSANTS

Unproductive distressing cough- central cough depressants e.g. pholcodine, dextromethorphan

Productive cough-do not use cough suppressantsUse expectorants and mucolyticsExpectorants-act by increasing the volume of secretions in respiratory tract so that they may be more easily removed by ciliary action and coughinge.g.ammonium salts, guaphenesin, ipecacuanha

Mucolytics- considered to affect sputum viscositye.g.acetylcysteine, bromhexine, carbocisteijne, methyl cysteine

The principal non-opioid antitussiveDextromethorphan-has a central action on the cough centre.Morphine and related opioids depress the cough reflex , at least in part by a direct effect on the cough centre in the medulla. Suppression of cough by such agents appear to involve receptors in the medulla that are less sensitive to naloxone than are those responsible for analgesia.Structurally related to morphine but little or no analgesic properties, And minimal (little) sedative activity.Antitussive effects may persist for up to 5 hours. Dextromethorphan should not be administered to patients with or at risk of •Developing respiratory failure.•Do not administer to patients on monoamine oxidase inhibitors-risk of severe reactions-hyperpyrexia, fatalitiesPHOLCODINECENTRALLY ACTING COUGH SUPPRESSANTUNLIKE CODEINE, THERE IS LITTLE OR NO METABOLISMTO MORPHINELONGER HALF-LIFE THAN CODEINE- DOSES MAY BE GIVEN ONCEOR TWICE A DAY

ANTIHISTAMINES E.G. DIPHENHYDRAMINEOFTEN USED AS ANTI-TUSSIVESMODE OF ACTION – Due to sedative and ant cholinergic

actions.

SUGGESTIONS-

a. Reduction in cholinergic transmission

b. Suppression of cough because of sedative action

c. Reduces nasal secretions and therefore the post-nasal drip that causes cough

d. Should not be used to treat productive cough as it increases the viscosity of the mucus

The viscosity of pulmonary mucus secretions depends on the concentrations of mucoproteinsand deoxyribonucleic acid (DNA).

While mucoprotein is the main determinant of viscosity in normal mucus, in purulent inflammation the mucoid concentration of DNA increases (due to increased cellular debris)and so does its contribution to mucoid viscosity.

Some patients with respiratory tract disease, the bronchial inflammation will be associated with the presence of large amounts of relatively viscous, inflammatory exudateand mucus which is firmly attached to the lining of bronchioles and bronchi.This would in practical terms increase bronchial wall thickness.

Adverse effects of increased mucus accumulation are

1. Increase the "lumen narrowing" effects of bronchial constriction 2. Enhance the overall inflammatory process 3. Potentiate persistent coughing.

Mucolytics would be useful in facilitating recovery/relief of symptoms

The two most frequently prescribed mucolytics

• bromhexine hydrochloride

• Acetylcysteine-probably reduces viscosity by splitting the disulphide bonds in mucoproteins

• Other forms: Normal saline, directly administered to the airways by

effective nebulisation therapy-extremely effective mucolytic and expectorant

DORNOSA ALFA

ACTS AS A MUCOLYTIC

BY HYDROLYSING DNA THAT HAS ACCUMULATED IN THE SPUTUM FROM DECAYING NEUTROPHILS

USED AS A NEBULIZING SOLUTION IN PATIENTS WITH CYSTIC FIBROSIS

BRONCHODILATION ACHIEVED

• via anticholinergic agents- ipratropium bromide 0.5 mg nebulised repeat every six hours (including beta 2 agonists),

• beta 2 adrenergic receptor agonists –nebulised salbutamol (2.5-5.0 mg every two to six hours, terbutaline

• agents such as the methylxanthines which produce bronchodilation at least in part due to increased intracellular cAMP levels in bronchial smooth muscle.

•Inhaled anti-inflammatory agents- corticosteroids- beclomethasone or budenoside 100-400 micrograms twice daily

• Oral corticosteroids-40-60 mg once daily

•Intravenous hydrocortisone- 200 mg every six hours

Adrenergic agonists

All adrenergic agonists have variable alpha and beta receptor affinity.

Due to the distribution of alpha and beta receptors-non-selective beta receptor agonists such as isoprenaline ormixed alpha and beta receptor agonists such as adrenaline are more likely to produce cardiovascular side effects than similarly administered selective beta agonists.

THEREFORE DRUGS WITH PREFERENTIAL AFFINITY FOR BETA 2 RECEPTORS PROVIDE MORE EFFECTIVE BRONCHODILATION WITH FEWER SIDE EFFECTS.

A possible exception may be with the treatment of acute allergic bronchospasm. The M-2 receptor-mediated inhibition of cholinergic bronchospasm may be helpful. For this reason, the use of an adrenergic agent with both alpha 2 and beta 2 agonist activity may be beneficial in the peracute management of allergic bronchospasm. Due to risks associated with administering systemic non-selective adrenergic agonists to a hypoxic and already tachycardic patient, it is preferable for them to be administered by inhalation.

Selective beta 2 agonists- lead to rapid and effective pulmonary beta 2 receptor activation with low systemic drug concentrations by inhalation of small doses of the drug in aerosol form.

METHYLXANTHINES POSSIBLE ACTIONS1.Relaxation of smooth muscle, particularly bronchial smooth muscle2.Stimulate the central nervous system3.Weakly positive chronotropes and inotropes 4.Mild diuretics.

Naturally occurring methylated xanthinesCaffeine, theophylline and theobromine - relatively insoluble. Solubility enhanced by the formation of complexes with a wide variety of compounds e.g. aminophylline which is the ethylenediamine complex of theophylline with differing quantities of water of hydration.When dissolved in water, aminophylline readily dissociates to its parent compounds.

Theophylline has a low therapeutic index- Therefore dose rates should be determined on lean body mass.

The dose rate of theophylline varies depending on the preparation used.

Widely available at present- codeine phosphate and hydrocodone.

Codeine has a high oral-parenteral potency with oral administration providing around 60% of its parenteral efficacy. Once absorbed, codeine is metabolized by the liver . Inactive metabolitesexcreted predominantly in the urine. In man approximately 10% of administered codeine is demethylated to form morphine -and both free and conjugated forms of morphine can befound in the urine of patients receiving therapeutic doses of codeine.

In man, codeine's plasma half-life is around 2 to 4 hours.

Codeine phosphate is contained in numerous "over the counter" analgesic preparations as well as in 30 and 60mg tablets which have restricted scheduling.

Hydrocodone is generally marketed in combination with homatropine as both an elixir and tablet formulations. The addition of homatropine is designed to enhance any reduction in respiratory secretions, which may come about as a result of the administration of hydrocodone.

BENZONATATECough suppressant believed to act both centrally and peripherally.Related to amethocaine ( a local anaesthetic) and therefore has a local anaesthetic action onthe mucosa. .

OPIOID ANTITUSSIVES

LEUKOTRIENE RECEPTOR ANTAGONISTS

Inflammation of the respiratory tract is frequently characterised by the classical markers of inflammation;•accumulations of inflammatory cells•exudate.•associated with varying degrees of bronchoconstriction •and, or, bronchospasm.• Additionally "airway hyper reactivity" may become a standard response of sensitised patients to various inhaled compounds.

Although glucocorticoids remain the "gold standard" in controlling this inflammatory-induced bronchoconstriction, the leukotriene receptor antagonists represent a new class of drugs which may facilitate management of these various forms of bronchoconstriction.

DEMULCENTS

INDIRECTLY ACTING COUGH SUPPRESSANTS? MODE OF ACTIONPOSSIBLY BY PROVIDING A PROTECTIVE COATING OVER THE SENSORY RECEPTORS IN THE PHARYNX

EXAMPLES- GLYCEROL, HONEY, LIQUORICE AND SUCROSE SYRUPS

HYDRATION

1.LIQUEFYING MUCUS

2.DEMULCENT EFFECT

3.METHODSDRINK PLENTY OF FLUIDSSTEAM INHALATION

INHALATION OF AEROSOLS CONTAININGWATER, SODIUM BICARBONATE, SODIUM CHLORIDE, SURFACTANTS E.G. TYLOXAPALPROTEOLYTIC ENZYMES E.G. CHYMOTRYPSIN, TRYPSIN

BTS GUIDELINES FOR MANAGEMENT OF ASTHMA

1.INHALED SHORT-ACTING BETA-2 AGONIST AS REQUIRED

2.ADD INHALED STEROID-200-800MICROGRMS/DAY

3.ADD INHALED LONG-ATINGBETA 2 AGONIST- CONSIDER INCREASING STEROID INHALED DOSE

4.CONSIDER USING LEUKOTRIENE RECEPTOR ANTAGONIST OR THEOPHYLLINE

ADAPTED FROM THORAX 2008;63 (suppl 4):

ACUTE BRONCHITIS

TREATMENT USUALLY NOT REQUIRED IN PREVIOUSLY HEALTHY PATIENTS BELOW AGE 60

EXACCERBATION OF COPD-START WITH DOXYCYCLINE 200MG OD -SECOND LINE-AMOXICILIIN (OR CO-AMOXICLAV)BRONCHIECTASIS-CO-AMOXICLAV 1.2 G TDS IV OR IF AVAILABLE PIPERICILLIN + TAZOBACTAM 4.5 G TDS

CYSTIC FIBROSIS- CIPROFLOXACIN 500MG BD ORALLY OR 400MG BD IV IF PSEUDOMONAS IS SUSPECTED

Adapted from Pocket Prescriber

ADVERSE EFFECTS OF INHALED CORTICOSTEROIDS EXAMPLE BECLOMETASONE

1.ORAL CANDIDIASIS ( decreased by rinsing mouth with water after use)2.HOARSE VOICE-3.RARELY GLAUCOMA4.INCREASING DOSES MAY CAUSE ADRENO-CORTICAL SUPPRESSION, CUSHING’S 5.DECREASE IN DENSITY OF BONES6.DECREASE IN GROWTH HORMONE ?7.Very rarely-paradoxical bronchospasm

Adapted from Pocket Prescriber

SALBUTAMOL

BETA 2 AGONIST- SHORT ACTING

ACTIONS:

1. DILATES BRONCHIAL SMOOTH MUSCLE2. RELAXES UTERINE SMOOTH MUSCLE3.INHIBITS MAST-CELL MEDIATOR RELEASE

BEWARE USE -IN CARDIO-VASCULAR DISEASE Esp. arrhythmias-susceptibility to increased QTc - DIABETES MELLITUS- MAY INCREASE RISK OF DIABETIC KETO-ACIDOSIS - MAY INCREAE THYROXINE LEVELS

SIDE EFFECTS- FINE TREMOR, HEADACHE, NERVOUSNESS INCREASE IN HEART RATE, PALPITATIONS, ARRHYTHMIAS DECREASE IN SERUM POTASSIUM MUSCLE CRAMPS

Prolonged treatment -? Increased risk of glaucoma

THEOPHYLLINEMETHYLXANTHINE BRONCHODILATOR- Additive effects with beta 2 agonists but increases risk of hypokalaemiaBeware – caution in patients with

• Cardiac disease especially risk of arrhythmias,

• Epilepsy

• Peptic ulcer

• Hypertensive heart disease

• Fever

• Porphyria

• In acute febrile illness

• Glaucoma

• Diabetes mellitus

SIDE EFFECTS-

• ARRHYTHMIAS

• SEIZURES

• GASTRO-INTESTINAL UPSET- NAUSEA

• RESTLESSNESS, INSOMNIA

• HEADACHE

• LOWERS SERUM POTASSIUM

MONITOR- SERUM POTASSIUM, BLOOD LEVELS 6 HR AFTER ADMINISTRATION

TOXIC EFFECTS MAY OCCUR EVEN WITH NORMAL BLOOD LEVELS E.G. 10-20MG/L

THEOPHYLLINE

MONTELUKAST

LEUKOTRIENE RECEPTOR ANTAGONIST

CAUTION

1.ACUTE ASTHMA

2.CHURG-STRAUSS SYNDROME (asthma with + or – rhinitis, sinusitis with sytemic vasculitis and increased eosinophil counts

MONTELUKAST

SIDE EFFECTS

1.HEADACHE2.GASTRO-INTESTINAL UPSET3.MYALGIA4.DRY MOUTH/THIRST

MONITORFULL BLOOD COUNTWATCH FOR VASCULITISPERIPHERAL NEUROPATHYINCREASED CARDIAC AND RESPIRATORY SYMPTOMS