Tel (602) 277-5551 Ext. 2866 Fax (602) 222-2705 Robert.Frykberg@med.va.gov

Robert G. Frykberg, DPM, MPH Chief, Podiatry Section

Carl T. Hayden VA Medical Center 650 E. Indian School Rd., CS 112

Phoenix, AZ 85012

September 12, 2005 Shane Mangrum, MD Western Rehabilitation 2860 Channing Way, Ste. 114 Idaho Falls, ID 83404 Dear Dr. Mangrum. I am happy to affirm my enthusiasm about working with you on your proposed projects dealing with the dynamic vacuum compression stocking for the treatment of venous insufficiency and diabetic lower extremity wounds. These are enormously difficult problems for all of us in clinical practice and any new modality that could potentially expedite their healing would be most welcome. With millions of new venous ulcers and almost one million new diabetic foot ulcers developing in this country each year, the impact of a new effective therapy would be quite significant. I look forward to working with you in this venture and stand ready to assist you as the time approaches to plan and execute the necessary clinical trials. Very truly yours,

Robert. G. Frykberg, DPM, MPH

Carl T. Hayden V.A. Medical Center 650 East Indian School Rd. Phoenix, AZ 85012

CURRICULUM VITAE 12/01/04

ROBERT G. FRYKBERG, DPM, MPH Birthdate: July 13, 1951 Undergraduate Education: University of Rhode Island: 1969-1973 Graduated 6/73: B.S. in Zoology, Cum Laude Professional Education: California College of Podiatric Medicine San Francisco, CA : 1973-1976 (accelerated) Graduated 6/76 : Doctor of Podiatric Medicine (DPM) Harvard University - School of Public Health Master of Public Health (MPH) - 1994 concentration in Quantitative Methods Post-Doctoral Training: Resident in Podiatric Medicine and Surgery: 7/76-6/78 New England Deaconess Hospital / Harvard Medical School , Boston, MA Hospital Affiliations: Carl T. Hayden VA Medical Center, Phoenix, AZ – Department of Surgery Chief, Podiatry Section (7/01/03) Academic Appointments: Associate Professor of Podiatric Medicine (1999-2003) Dean for Clinical Affairs, College of Podiatric Medicine and Surgery

Des Moines University – Osteopathic Medical Center, Des Moines, IA Clinical Instructor in Surgery (1997-1999) Harvard Medical School Beth Israel Deaconess Medical Center, Boston, MA Board Certifications and Fellowships: Diplomate, American Board of Podiatric Surgery (1982) Diplomate, American Board of Podiatric Orthopedics (1988) Diplomate, American Board of Podiatric Orthopedics and Primary Podiatric medicine (1995) Diplomate, American Board of Quality Assurance and Utilization Review (1988) Fellow, American College of Foot and Ankle Surgeons (1983) American College of Foot and Ankle Surgeons- Research Fellowship 1992 American Podiatric Medical Association Post Doctoral Fellow 1993-1994

Carl T. Hayden V.A. Medical Center 650 East Indian School Rd. Phoenix, AZ 85012

Professional Societies and Distinctions: Who's Who in American Colleges and Universities 1975 Pi Delta National Podiatry Honor Society 1976 American Podiatric Medical Association (APMA) 1976 to present President, Mass. Podiatric Medical Society 1984-1985 American Diabetes Association Massachusetts Board of Registration in Podiatry – Board Member 1988-1992 Massachusetts Delegate to APMA House of Delegates 8/84-8/89, 8/93-8/94 National Academies of Practice Distinguished Practitioner, elected 1996 American College of Foot and Ankle Surgeons, Board of Directors 1997-2004 American College of Foot and Ankle Surgeons, President 2002-2003 American Diabetes Association, Foot Care Council Program Chair, 1996 and 1997 American Diabetes Association, Foot Care Council Chair, 1999 through 2001 Professional Activities: Contributing editor, Journal of Foot and Ankle Surgery Manuscript Reviewer, Diabetes Care American Podiatric Medical Association- Research Grant Review Committee 1994 Examinations Committee, American Board of Podiatric Orthopedics (1990) Oral Examiner, American Board of Podiatric Surgery (1989,1990,1994) Oral Examiner, American Board of Podiatric Orthopedics (1990,1991) Region I APMA Conference- General Chairman 1984-1988 New England Division ACFAS- Conference Co-Chairman and Scientific Committee 1988-1994 Past Chairman and Residency Director, Department of Podiatric Surgery, Massachusetts Osteopathic Hospital, Boston 1986-1989 Chief, Podiatry Section and Residency Director, Carl T. Hayden VA Medical Center, Phoenix 2003 Publications: • Frykberg R, Erben J:The biochemistry and physiology of the surgical scar.

J Am Pod Assoc. 67:3, 1977. • Frykberg R, Locke R:The treatment and prevention of intractable plantar scars.

J Am Pod Assoc. 67:70, 1977. • Frykberg R, Kozak G:Neuropathic arthropathy in the diabetic foot.

American Family Physician 17:105, 1978. • Frykberg R: The Diabetic Charcot Foot.

Archives of Podiatric Medicine and Surgery 5:15, 1978 • Hill E, Frykberg R, Donovan J:New England Deaconess Hospital Podiatry Service: Sport

Orthotic Device J Am Podiatry Assoc. 69:571, 1979 • Frykberg R: Neuro-arthropathy in the diabetic foot. In: Kozak,GP (ed.): Clinical Diabetes

Mellitus. W.B. Saunders Co., Philadelphia, 1982 pp 415-425. • Frykberg R: Podiatric problems in diabetes. In: Kozak, GP (ed.): Clinical Diabetes Mellitus.

W.B. Saunders Co., Phila. 1982 pp. 426-438. • Frykberg R, Kozak G: The Diabetic Charcot Foot. In: Kozak, GP et al. (eds.): Management of

Diabetic Foot Problems. W.B. Saunders Co. Phila., 1984 pp113-121.

Carl T. Hayden V.A. Medical Center 650 East Indian School Rd. Phoenix, AZ 85012

• Frykberg R: Podiatric problems in diabetes. In: Kozak, GP et al. (eds.): Management of Diabetic Foot Problems. W.B. Saunders Co., Phila., 1984

• Frykberg R: Osteoarthropathy. Clinics in Podiatric Med Surgery. 4:351-359, 1987. • Frykberg R: Emerging Technologies in Podiatric Medicine. (Guest Editor): Clinics in Podiatric

Medicine and Surgery. Vol 4, Number 4, October, 1987. • Frykberg R: Lasers in Podiatry. Clinics in Pod Med Surg. 4:767-776, 1987. • Frykberg R: Diabetic Osteoarthropathy. In: Brenner, Marc (ed.): Management of the diabetic

foot. Williams and Wilkins, Baltimore, 1987, pp 75-86. • Frykberg, RG (editor). The High Risk Foot in Diabetes Mellitus.

Churchill Livingstone, Inc. New York, 1991. • Glod D, Frykberg R: Foreign body reaction in a dacron-meshed hemi-implant.

JFoot Surg. 29:3, 1990. • Arlen D, Frykberg R , Harkless L: Skilled nursing facility units. J Am Pod Med Assoc. 80:7,

1990. • Frykberg R : Diabetic Foot Ulcers. In: Frykberg, RG (ed.): The High Risk Foot in Diabetes

Mellitus. Churchill Livingstone, New York, 1991. • Sanders L, Frykberg R : Diabetic Neuropathic Osteoarthropathy. In: Frykberg, RG (ed.): The

High Risk Foot in Diabetes Mellitus. Churchill Livingstone, New York, 1991. • Sanders L, Frykberg R : Charcot Foot. In: Levin ME, O'Neal LW, Bowker JH (eds.): The Diabetic

Foot. 5th Edition. pp 149-180. Mosby Yearbook, Inc., St. Louis, 1993. • Frykberg R , Giurini J, Rosenblum B, Chrzan J, Habershaw G: Prophylactic Surgery in the

Diabetic Foot. In Kominsky SJ (ed.): Medical and Surgical Management of the Diabetic Foot. pp 399-439 Mosby, St. Louis, 1994.

• Kozak GP, Campbell DR, Frykberg RG, Habershaw GM (eds.) :Management of Diabetic Foot Problems (2nd Ed.) WB Saunders Co. 1995

• Frykberg R : Podiatric Problems in Diabetes. In Kozak GP, Campbell DR, Frykberg RG, Habershaw GM (eds.) :Management of Diabetic Foot Problems (2nd Ed.) WB Saunders Co. 1995

• Frykberg R, Kozak G: The Diabetic Charcot Foot. In Kozak GP, Campbell DR, Frykberg RG, Habershaw GM (eds.): Management of Diabetic Foot Problems (2nd Ed.) WB Saunders Co. 1995

• Frykberg R : Biomechanical considerations of the diabetic foot. Lower Extremity. 2:207-214, 1995.

• Frykberg R : Podiatrists Role in the Care and Treatment of the Diabetic Foot. p734-743. In Baba S, Kaneko T. (eds.):Diabetes 1994. Elsevier Science, Amsterdam, 1995.

• Frykberg R : Pathways to Diabetic Limb Prevention; Basis for Prevention (Commentary): Foot Ankle Quarterly 8:170-173, 1995

• Frykberg R : Foot and Ankle. pp 1064-1084. In Noble J (ed): Primary Care Medicine, 2nd Edition. Mosby - Yearbook, Inc. St. Louis, MO. 1996

• Frykberg R , Piaggesi A, Donaghue V, Scipiani E, Habershaw G, Navalesi R, Veves A:Outcome Variation of Foot Ulcer Treatment in Two Different Centers (Abstract): Diabetes 45:284A, 1996

• Frykberg R , Veves A:Diabetic Foot Infections. Diabetes/ Metabolism Reviews. 12:255-70, 1996 • Frykberg R , Piaggesi A, Donaghue V, Scipiani E, Habershaw G, Navalesi R, Veves A: Difference

in Treatment of foot ulcerations in Boston, USA and Pisa, Italy: Diabetes Research Clinical Practice 35:21-26, 1997

• Frykberg RG: Diabetic Foot Ulcers. Practical Diabetes International 14:81-83, 1997

Carl T. Hayden V.A. Medical Center 650 East Indian School Rd. Phoenix, AZ 85012

• Racial Differences in Risk Factors for Foot Ulceration Among Caucasian, Black, and Hispanic Diabetic Patients (Abstract): Diabetes 46 (S1):327A, 1997

• Functional Outcome in the Elderly Following Lower Extremity Amputation (Abstract): Diabetes 46 (S1):151A, 1997

• Microcirculation in the Foot and Forearm is Equally Impaired in Diabetic Neuropathy (Abstract): Diabetes 46 (S1):11A, 1997

• Lower Limb Revascularization in Octogenarians with Diabetes Mellitus is Safe and Preserves Function (Abstract): Diabetes 46 (S1):327A, 1997

• Frykberg RG: Team Approach Toward Lower Extremity Amputation Prevention in Diabetes. J Am Podiatric Med Assoc. 7:305-312, 1997

• Grand Rounds: Wound Management in the Diabetic Foot. J Foot Ankle Surg 36:240-254, 1997

• Frykberg RG: The Team Approach in Diabetic Foot Management. Adv Wound Care 11:71-77, 1998

• Frykberg RG, Arora S, Pomposelli FB, LoGerfo F: Functional Outcome in the Elderly Following Lower Extremity Amputation. J Foot Ankle Surg 37:181-185, 1998

• Caballero E, Frykberg RG: Diabetic Foot Infections. J Foot Ankle Surg 37:248-255, 1998 • Frykberg R, Habershaw G, Chrzan J: Epidemiology of the Diabetic Foot: Ulcerations and

Amputations. pp 273-290 In Veves, A. (ed.): Clinical Management of Diabetic Neuropathy. Humana Press, Totowa, NJ. 1998.

• Frykberg RG, Sanders L, Marzano R: Feet. pp 42-66. In Levin ME and Pfeiffer MA (eds.): The Uncomplicated Guide to Diabetes Complications. American Diabetes Association, Alexandria, VA. 1998

• Frykberg RG, Pham H, Harvey C, Lavery L, Harkless L, Veves A: The risk of ulceration in diabetic patients with high foot pressures and neuropathy (Abstract): Diabetes 47 (Suppl 1):A166, 1998

• Pham H, Frykberg RG, Lavery L, Harvey C, Veves A: Risk Factors for Development of Foot Ulceration: One year Prospective Follow-up (Abstract): Diabetes 47 (Suppl 1):A19, 1998

• Frykberg RG: Offloading Properties of a New Rocker Insole (Abstract): Diabetes 47 (Supp1):A168, 1998

• Arora S, Smakowski P, Frykberg RG, Simeone LR, Freeman R, LoGerfo FW, Veves A: Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy. Diabetes Care 21:1339-1344, 1998

• Frykberg RG, Lavery LA, Pham H, Harvey C, Harkless L, Veves A: Role of neuropathy and high foot pressures in diabetic foot ulceration. Diabetes Care 21:1714-1719, 1998

• Pomposelli FB, Arora S, Gibbons GW, Frykberg R, Smakowski P, Campbell D, Freeman D, LoGerfoF: Lower extremity arterial reconstruction in the very elderly: successful outcome preserves not only the limb but also residential status and ambulatory function. J Vasc Surg 28:215-225, 1998

• Frykberg RG: Diabetic foot ulcers: Current concepts. J Foot Ankle Surg 37:440-446, 1998 • Frykberg RG: Diabetic Foot Infections: evaluation and management. Adv Wound Care 11:248-

250, 1998 • Sanders L, Frykberg R : Charcot Foot. In: Levin ME, O'Neal LW, Bowker JH, Pfeiffer M (eds.):

The Diabetic Foot. 6th Edition. Mosby Yearbook, Inc., St. Louis, 2000. • Frykberg, RG: Epidemiology of the diabetic foot. Advances in Wound Care. 12:139-141, 1999

Carl T. Hayden V.A. Medical Center 650 East Indian School Rd. Phoenix, AZ 85012

• Frykberg RG: Charcot Foot: An update on pathogenesis and management. In Boulton, Connors, and Cavanagh (eds.): The Foot in Diabetes, 3rd Ed. John Wiley, London. 2000.

• Frykberg RG, Armstrong DG, Giurini J, Edwards A, Kravette M, Kravitz S, Ross C, Stavosky J, Stuck R, Vanore J: Diabetic foot disorders; a clinical practice guideline. J Foot Ankle Surg. 39 (Suppl 1): 1-60, 2000

• Frykberg RG, Mendeszoon ER: Management of the diabetic Charcot foot. Diabetes Metab Res Rev 2000; 16 (Suppl 1): S59-S65

• Frykberg RG, Mendeszoon ER: Charcot Arthropathy: Pathogenesis and Management. Wounds 2000; 12 (6 Suppl B):35B-42B

• Frykberg RG, Pehde C, Beecroft J: The Prevalence of Foot Problems in Patients with Diabetes Undergoing Hemodialysis. (abstract) Diabetes 50 (Suppl 2):A485, 2001

• Frykberg RG:American College of Foot and Ankle Surgeons: Diabetic Foot Disorders: A Clinical Practice Guideline. Wounds 2001;13 (Suppl E):9E-10E

• Frykberg,RG: Prophylactic Surgery in the Diabetic Foot. Diabetologia 45 (Suppl 2):A343, 2002 (Abstract)

• Frykberg RG, Armstrong DG: The diabetic foot 2001: a summary of the proceedings of the American Diabetes Association’s 61st scientific symposium. J Am Podiatric Med Assoc 92:2-6, 2002

• Frykberg RG, Bailey LF, Matz A, Panthel L, Ruesch G: Offloading properties of a rocker insole: a preliminary study. J Amer Podiatric Med Assoc. 92:48-53, 2002

• Frykberg RG: Charcot changes in the Diabetic Foot. Pp221-246 In: Veves A, Giurini JM, LoGerfo FW (eds), The Diabetic Foot: Medical and Surgical Management. Humana Press Inc., Totowa, NJ 2002

• Frykberg,RG: Prophylactic Surgery in the Diabetic Foot. Diabetologia 45 (Suppl 2):A343, 2002 (Abstract)

• Frykberg RG: Diabetic foot ulcers: Pathogenesis and management. Am Fam Physician; 66:1655-62, 2002

• Armstrong DG, Frykberg RG: Classifying diabetic foot surgery: toward a rational definition. Diabetic Med 20: 2003

• Frykberg RG: Diabetic foot ulcerations: management and adjunctive therapy. Clin Podiatr Med Surg 20: 709-728, 2003

• Frykberg RG: An evidence-based approach to diabetic foot infections. American Journal of Surgery. 186 (Suppl 1):44-54, 2003

• Armstrong DG, Attinger CE, Boulton AJM, Frykberg RG, Lavery LA, MillsJL: Guidelines regarding negative pressure wound therapy (NPWT) in the diabetic foot: Results of the Tucson Expert Consensus Conference (TECC) on VAC Therapy. Ostomy Wound Management 50 (Suppl B)3S-27S, 2004

• Frykberg RG: Diabetic Foot Infections (Audio Lecture). Foot and Ankle Quarterly. Vol 16, No. 3, 2004. Data Trace Publishing

CURRICULUM VITAE PART I: GENERAL INFORMATION Date updated: December 23, 2004 Name Aristidis VEVES Office Address 317 Palmer Building, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Rd., Boston, MA, 02215 Tel: (617) 632-7075 Home Address 215 Victory Road, Quincy, MA, 02171, USA

Tel: (617) 471-1380 Fax: (617) 632-7075 email: aveves@bidmc.harvard.edu Place of Birth Mouriatada, Messinia, Greece

Education 1981 MD Medical School, Aristotelion University of Thessaloniki, Greece. 1991 MSc Faculty of Medicine, University of Manchester, UK

1993 DSc Doctoral in Science Athens Medical School, Greece

Post doctoral training Internships and Residencies 1983 - 1984 Internship in General Medicine Athens Naval Hospital, Greece 1986 - 1987 Residency in General Medicine Tsaggari General District Hospital, Athens, Greece. 1987 - 1988 Hon Senior House Officer University Department of Medicine, Diabetes and Endocrinology. Manchester Royal Infirmary, UK

Clinical and Research Fellowships 1988 - 1992 Clinical Research Fellow University Department of Medicine, Diabetes and Endocrinology, Manchester Royal Infirmary, UK 1992 -1993 Temporary Lecturer and Hon Senior Registrar. University Department of Medicine, Diabetes and Endocrinology, Manchester Royal Infirmary, UK 1993-1995 Research Fellow Deaconess - Joslin Foot Center, Deaconess Hospital, Harvard University, Boston, MA, USA Academic appointments 1988-1993 Clinical Fellow in Medicine, Manchester Medical School, UK 1993- 1995 Research Fellow in Surgery, Harvard Medical School, MA 1995- 1999 Instructor in Medicine, Harvard Medical School, MA

2000-2003 Assistant Professor of Surgery, Harvard Medical School, MA

2004- Associate Professor of Surgery, Harvard Medical School, MA

Hospital Appointments 1988-1992 Registrar in Medicine Manchester Royal Infirmary, UK 1992-1993 Locum Senior Registrar in Medicine Manchester Royal Infirmary, UK 1995-1996 Research Staff, Deaconess Hospital,

Dept of Medicine, Research Director, Deaconess-Joslin Foot Center Boston, MA, USA

June 1996- Research Staff, Beth Israel Deaconess Medical Center, Dept of Surgery,

Major Administrative Responsibilities 1995- Research Director, Joslin-Beth Israel

Deaconess Foot Center and Microcirculation Lab, Boston, MA,

Major Committee Assignments

1999- Research Grant Review Committee of the Juvenile Diabetes Research Foundation International, member

1999-2002 Johnson & Johnson Medical Scientific Advisory Committees: Diabetes Wound Care Management Advisory Board

1999-2000 Novartis, Apligraf® Advisory Board, Member

1999-2000 Parke-Davis Zenarestat Scientific Advisory Board, member

2000 Pfizer Scientific Advisory Board on Neuropathic Pain, Member

2001- Inotek Scientific Advisory Board, Member

2001 Biogen Scientific Advisory Board, Member

2001- Pfizer, Lipitor Scientific Advisory Board, Member

2002- Grant Review Panel, American Diabetes Association, member

2004 Ad hoc member, NHLBI Mentored Patient Oriented Research Career Development Award Panel for K23, K24 and K25 applications and R13 Conference Grants

Military and community services

1982-1984 Greek Navy. Obligatory service as a medical doctor.

1984-1986 Obligatory service as general practitioner at Vitalo Evia, a rural area of Greece

Professional Societies 1989- European Association for the Study of Diabetes (EASD) 1991- Neuropathy Study Group of EASD 1994- American Diabetes Association Editorial Boards

Editorial Advisory Board: Wounds: A Compendium of Clinical Research and Practice (1999-2000). Associate Editor: Wounds: A Compendium of Clinical Research and Practice (2000-).

Editorial Advisory Board: International Journal of Lower Limb Wounds (2003-) Editorial Advisory Board: Current Diabetes Reviews (2004-) Series editor of Diabetes and Endocrinology, Human Press, Totowa, NJ (2003-) I have been asked to act as a peer reviewer for the journals: American Journal of Physiology, Diabetic Medicine, Journal of Diabetes and its Complications, Diabetologia, Diabetes Care, Western Journal of Medicine, Archives of Physical Therapy, JAMA, Diabetes, Clinical Science, The Journal of Clinical Investigation, American Journal of Hypertension, New England Journal of Medicine and the Lancet. I have also been asked to review abstracts submitted to the American Diabetes Association annual scientific meeting (2002, 2003). I have also been asked to review abstracts submitted to the International Diabetes Federation meeting (Paris 2003). I have been asked to review grant applications by the Departments of Veterans Affairs, Hospital at Seattle and Paolo Alto Health Care System (1998,2003), The University of Texas at San Antonio Tx (1998), and the Israel Science Foundation (1998).

Awards and Honors

2002 Mary Jane Kugel Award by the Juvenile Diabetes Research Foundation International for participation in Medical Science Review Committee.

2002 Chennai Diabetes Research Centre Gold Medal Oration Award

2004 Roger Pecoraro Lecture for my contribution to research

on the field of diabetic foot problems. PART II A. Narrative Description of Research

My main research interest is the vascular reactivity of micro- and macrocirculation. During the last few years, I developed the Microcirculation Lab, which tests the microvasculature in a non-invasive way. The Microcirculation Lab is also equipped with an ultrasound apparatus that enables evaluation of endothelial function in the brachial artery. Our research is mainly funded by grants from the NIH, American Diabetes Association and the Juvenile Diabetes Research Foundation. In addition, we conduct investigator-initiated studies that are funded by the pharmaceutical industry.

I am interested in the relationship between functional changes in the vascular reactivity and structural changes of the skin. In collaboration we investigators from other labs, we are currently involved in the study of mechanisms, such as eNOS and RAGE and PARP activation, that are involved in endothelial dysfunction that is present in diabetic patients.

My Laboratory is also collaborating with small biotech companies. This collaboration has resulted in funding from the NIH, either in the form of SBIR or SBTT grants. The main aim of these collaborations is to develop new techniques that can improve our diagnostic abilities or develop new therapeutic interventions that will treat long-term diabetic complications.

My group is also interested in the etiology of diabetic foot problems and the pathophysiology of wound healing in diabetes. We are currently conducting a larger prospective study that will evaluate the role of microvascular dysfunction in foot ulceration and wound healing failure.

In collaboration with the department of Radiology, we employ a 3 Tesla (3T) magnetic resonance scanner that can access metabolic activity through measurements of the concentrations and reaction rates of the high-energy phosphorus cellular compounds in humans by employing magnetic resonance imaging and spectroscopy methods. The main advantage of this technique is that it can give a direct non-invasive assessment of muscle metabolism. As a first step, we evaluate the effect of diabetes and its complications on the leg blood flow and metabolic function.

Finally, research in my Lab examines the natural history of the progression of peripheral neuropathy in diabetic patients.

B. Funding Information PREVIOUS FUNDING

“A clinical evaluation of a collagen-alginate topical wound dressing in the management of diabetic foot ulcerations”. Johnson & Johnson Inc Project Period: 12/1/94-30/11/95 Principal Investigator: Dr. Geoffrey M. Habershaw. Co-Investigator: Dr. Aristidis Veves

“The role of glucose transporters in long-term diabetes complications.” Central Research Division, Pfizer Inc. Project Period: 7/1/96-6/30/97 Principal Investigator: Dr. Aristidis Veves

“A multi-center prospective randomized controlled clinical trial of Graftskin for the

treatment of diabetic foot ulcers.” Organogenesis Inc Project Period: 4/1/97-6/30/99 Principal Investigator: Dr. Geoffrey M. Habershaw. Co-Investigator: Dr. Aristidis Veves

“Endothelial dysfunction in subjects with glucose intolerance.”

American Diabetes Association Project Period: 7/1/97-6/30/00 Principal Investigator: Dr. Edward S. Horton, (Joslin Diabetes Center). Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

“Microvascular changes in diabetes.” Beth Israel Deaconess Medical Center Project Period: 2/1/97-1/31/98 Principal Investigator: Dr. Aristidis Veves

“A prospective non-comparative evaluation of the Multi-Dress Products in Chronic

Wounds.” ConvaTec Inc. Project Period: 6/1/97-1/1/99 Principal Investigator: Dr. Aristidis Veves

“Effect of insulin-sensitizing agent troglitazone on the endothelial function of the micro- and macro-vasculature of subjects at risk of type 2 diabetes and type 2 diabetic patients with or without vascular complications. (investigator initiated research)” Parke-Davis Inc Project Period: 12/1/97-1/7/00

Principal Investigator: Dr. Aristidis Veves “A comparison of the UK-97-005 Dressing versus saline moistened gauze in the

management of diabetic foot ulcers.” Johnson and Johnson Inc. GC-97-35/0724 Project Period: 1/3/99-1/1/01 Principal Investigator: Dr. Aristidis Veves

“A Single-Center, Prospective Clinical Trial of Graftskin for the Treatment of Deep

Diabetic Foot Ulcers” Organogenesis Inc Project Period: 1/1/99-30/6/00 Principal Investigator: Dr. Aristidis Veves

“Effect of Atorvastatin on the endothelial function in Diabetes and pre-Diabetes”

(investigator initiated research)” Parke-Davis, Pfizer, NY, 981-952-477 Project period: 10/1/00-6/30/02 Principal Investigator: Dr. Aristidis Veves

“Effect of Angiotensin Converting Enzyme Inhibitor Quinapril on the Endothelial

Function of the Micro- and Macro- Vasculature of Subjects with Impaired Glucose Tolerance and Type 2 Diabetic Patients with or without Microalbuminuria (investigator initiated research)”

Parke-Davis, Pfizer, NY, 906-953-444 Project period: 10/1/00-6/30/02 Principal Investigator: Dr. Edward Horton, (Joslin Diabetes Center). Co- Investigator: Dr. Aristidis Veves

“A prospective, randomized, comparative parallel study of Hyalofill wound dressing in the management of indolent diabetic foot ulcers”

ConvaTec, Princeton NJ, CW-0130-00-A509 Project period: 2/1/01-1/31/2003 Principal Investigator: Dr. Aristidis Veves

“Vitrix for the treatment of deep diabetic foot ulcers”

Organogenesis Inc, Canton, MA, 00-DUS-001-VX Project period: 9/01/01-8/31/02 Principal Investigator: Dr. Aristidis Veves

“Comparison of skin vascular reactivity to different vasodilatory substances in diabetic

patients and healthy subjects” Biochemics, Beverly, MA, W-01-0249-FB Project period: 10/1/01-30/9/02 Principal Investigator: Dr. Aristidis Veves

“Restoring diabetic tactile sense with mechanical noise” National Institutes of Health/SBIR Project period: 7/1/2001-12/31/01 Principal Investigator: Dr. Jason Harry Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

CURRENT FUNDING

“The Effect of Vitamin E on the Left Ventricular Function and the Endothelial Function of the Micro- and Macro-Circulation of Type1 and 2 Diabetic Patients” Juvenile Diabetes Foundation International, JDFI 1-1999-817 Project period: 10/1/99-9/30/04 Principal Investigator: Dr. Aristidis Veves

“MRI techniques in measuring vascular function of the diabetic foot”

Juvenile Diabetes Research Foundation, JDRF 5-2002-329 Project period: 05/01/02-11/30/03 Principal Investigator: Dr. Aristidis Veves

“Pilot & Feasibility Program in Diabetes, Endocrinology & Metabolism”

National Institutes of Health, RO1 PA-99-036 Project period: 07/01/02-6/30/04 Principal Investigator: Dr. Robert Greenman Co- Investigator: Dr. Aristidis Veves

“Effect of Valsartan in Ventricular Function and Aortic Elasticity (investigator initiated research)” Novartis Pharma Inc Project period: 09/01/02-08/31/04 Principal Investigator: Dr. Aristidis Veves

“Effect of Valsartan In Endothelial Function (investigator initiated research)” Novartis Pharma Inc Project period: 09/01/02-08/31/04 Principal Investigator: Dr. Aristidis Veves

“Mechanism of Cardiovascular Dysfunction in Diabetes”

National Institutes of Health, 1R01HL/DK71215-01 Project period: 10/1/02-30/9/05 Principal Investigator: Dr. Csaba Szabo (Inotek Corporation). Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

“Imaging early markers of diabetic microvascular complications in peripheral

tissue” National Institutes of Health, RFA-DK-02-001

Project period: 10/01/02-09/30/04 Principal Investigator: Dr. George L. King, (Joslin Diabetes Center). Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

“Micro- and Macrovascular Abnormalities and Diabetic Foot Ulceration”

American Diabetes Association Project period: 2/01/03-1/31/06 Principal Investigator: Dr. Aristidis Veves

“A Multicenter, Double-blind Study to Evaluate the Effect of Pre-treatment With a

Daily Dose of Viagra® (sildenafil citrate) on the PRN Efficacy of Viagra in Men With Erectile Dysfunction and Type 2 Diabetes” Pfizer Inc Project period: 2/01/03-10/31/04 Principal Investigator: Dr Richard Sparks Co- Investigator: Dr. Aristidis Veves

“A Phase 1 / 2 Study of Safety and Efficacy Topical Administration of Recombinant

Human Lactoferrin in Patients with Diabetic Neuropathic Foot Ulcers” Agennix Inc Project period: 2/01/03-1/31/05 Principal Investigator: Dr. Aristidis Veves

“A Phase IV Study of AQUACEL Ag versus Saline-Moistened Gauze in the Management of Diabetic Foot ulcers” ConvaTec, Princeton NJ, CW-0130-00-A509 Project period: 4/1/03-12/31/2004 Principal Investigator: Dr. Aristidis Veves

“Vascular and Metabolic Changes in the Diabetic Foot”

National Institutes of Health, RFA- HL-03-003 Project period: 10/01/03-09/30/06 Principal Investigator: Dr. Aristidis Veves

PENDING:

“Natural History of Small Fiber Diabetic Neuropathy” National Institutes of Health (Score 155, percentile 12) Project period: 12/1/04-11/30/09 Principle Investigator: Dr. Aristidis Veves

“Restoring diabetic tactile sense using mechanical noise”. National Institutes of Health Period: 8/1/04 – 7/31/06. Principle Investigator: Jason Harry, PhD. Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

(Grant provisionally funded pending satisfactory submission of requested information)

“Hyperspectral Imaging to assess, predict foot ulceration” National Institutes of Health Period: 9/19/04 – 9/19/05. Principle Investigator: Jenny Freeman, MD. Principal Investigator on the BIDMC subcontract: Dr. Aristidis Veves

C. Report on Current Research Activities During the last academic year we continued two investigator-initiated clinical studies that are related to vascular dysfunction in diabetes and were funded by Novartis Pharma Inc. In addition, we continued the study that is funded by the three-year clinical research grant from the American Diabetes Association and the three-year NIH grant. The main aim is to study the relationship between vascular abnormalities and diabetic foot ulceration. Finally, I was awarded a 5-year NIH grant that will investigate the natural history of peripheral neuropathy. In addition, I am the PI for BIDMC in a SBIR (R44) NIH grant awarded to Jason Harry from Afferent Inc. and a SBTT (R41) NIH grant awarded to Jenny Freeman from HyperMed Inc.

D. Report of teaching 1. Local Contributions

a. Medical School

Manchester Medical School, UK 1989-1993 Pharmacology, preclinical medical students

Prep time: 3 hours. Contact 1ime: 2 hour. Total time: Eight course per year

1989-1993 Medicine, Final year medical students

Prep time: 2 hours. Contact 1ime: 1 hour. Total time: Two course per year

b. Invited seminar presentation

1994, 1997 Neurologic Evaluation of the Diabetic Foot. At:

Lower Extremities Lecture Series, Deaconess Hospital. Harvard Medical School, Boston, MA. (contact time 1 hour, 50 participants)

1995, 1996 Overview of Diabetic Neuropathy. At: Diabetic Foot Management. Harvard Medical School, Department of Surgery, New England Deaconess Hospital and Joslin Diabetes Center (contact time 20 minutes, 300 participants)

1999-2002 Research Update at Diabetic Foot Management. Harvard

Medical School, (contact time 20, 250 participants)

2000 Diabetic Neuropathy: New Options at Emerging Clinical Issues in Managing Diabetes. Harvard Medical School, (CT 30 minutes, 60 participants)

c. Local Inviting teaching presentations

1997- Lecturer at Podiatry Residents teaching courses. There are

usually 3-4 residents each year and I give three lectures on research design, basic statistic analysis and data evaluation. Preparation time is about two hours for each lecture and contact time one hour.

d. Advisory and Supervisory Responsibilities in Laboratory Setting

1995-99 I have been responsible for supervising the Podiatry Research Fellow for his research activities. In this capacity, I have worked with Drs V. Donaghue (currently in private clinical practice in Boston, MA) and H.T. Pham (currently on staff at BIDMC and Clinical Instructor in Surgery, Harvard Medical School).

1995- I have been responsible for precepting in the

microcirculation lab the first year fellows in Vascular Surgery. During this year the fellows are involved exclusively in research activities. In this capacity, I have worked with 1. Dr C. Akbari, MD, currently at Washington

Hospital Center, Assistant Professor of Surgery, Georgetown University Medical School

2. Dr. S. Arora, MD, currently at Washington University Medical Center and Veterans Affairs Medical Center, Washington DC, Assistant Professor of Surgery, Washington University.

I have also been responsible for precepting in the microcirculation lab the research fellows in Diabetes and Endocrinology who are under the supervision of Dr. Edward S. Horton at Joslin Diabetes Center. Under this capacity, I have supervised:

1 A.E Caballero, MD, currently at Joslin Diabetes Center and Instructor in Medicine, Harvard Medical School,

2 S.C. Lim, MD, currently a Consultant Physician at Singapore

3 O. Hamdy, MD, currently at Joslin Diabetes Center and Instructor in Medicine, Harvard Medical School

4 K. Abou-Elenin, MD, currently a resident in anesthesiology, University of Miami,

5 P. Economidis, MD, currently at Joslin Diabetes Center and Instructor in Medicine, Harvard Medical School.

I have been responsible for training international fellows at the Joslin-Beth Israel Deaconess Foot Center and the Microcirculation Lab

1. A. Caselli, MD, an endocrinologist from the University of Rome Tor Vergata, Italy worked as a research fellow in our unit for two years (2000-2002). Dr Caselli is currently back at her previous position, Postgraduate Fellow in Rome.

2. Sriurai Porramatikul, MD, is an endocrinologist in Theptarin General Hospital. Bangkok, Thailand. Dr Porramatikul worked as a research fellow in our unit for three months (7/1/2003-9/30/2003).

Supervision of physicians who have finished their specialization training

1. L. Khaodhiar, MD, Division of Endocrinology, is working half time in my Lab since 5/03.

2. T. Dinh, DPM, staff podiatrist in the Podiatry Division is working 20% in my Lab since 2002

Finally, I have worked with summer students who visited my lab including D Singh Bedi, C O’Connor, C Shah.

2000- 2001 I was responsible for organizing the Joslin-Beth Israel

Deaconess Foot Center’s Preceptorship Program. This program was sponsored as an educational service by the Joslin-Beth Israel Deaconess Foot Center in conjunction with Novartis Pharma AG. It provided a three day educational forum to present some of the latest advances and techniques available to treat complicated lower extremity wounds. The participants are prominent European physicians who are interested in diabetic foot care. Two preceptorships have been held so far.

2. Regional, national or international contributions

a. Invited presentations 1989 Foot Pressure Measurements in the Diabetic Foot.. At:

The Diabetic Foot: A multidisciplinary approach. Department of orthopedics, Division of Podiatry, The University of Texas Health Science Centre at San Antonio, Texas (contact time 20 minutes, 300 participants).

The Use of Experimental Hosiery in Protecting the Insensitive Foot. At: The Insensitive Foot Seminar, Gillis W. Long Hansens Disease Center, Carville, Louisiana (contact time 20 minutes, 100 participants).

1990 Practical Demonstration: The protection of the high risk foot. At: International Meeting: The Diabetic Foot. Malvern, UK (contact time 30 minutes, 50 participants).

1991 The Diabetic Foot. At: The Wood Care Society Third Annual Conference, Nottingham, UK (contact time 1 hour, 200 participants).

1992 The Diabetic Foot (workshop). At: Postgraduate Course in Diabetes for the Primary Care Team. Warwick University, UK (contact time 3 hours, 30 participants).

1993 Nerve Function in Painful and Painless Diabetic Neuropathy. At: Anglo-Danish-Dutch Diabetes Group, 11th annual meeting, Holstebro, Denmark (contact time 20 minutes, 40 participants).

1994 Diabetic Neuropathy: Evaluation and Management, and Etiopathogenesis of Foot Ulceration in Diabetes. At: The Diabetic Foot. Update 1994: A multidisciplinary approach. Dept of Orthopaedics, The University of Texas Health Science Center at San Antonio, Texas (contact time 40 minutes, 300 participants).

1995 The Diagnosis of Peripheral Neuropathy American Diabetes Association 55th Annual Scientific Sessions. Atlanta, GA. (contact time 20 minutes, 300 participants).

1995-97 The Clinical Diagnosis of Peripheral Neuropathy.

Workshop at the American Diabetes Association Annual Scientific Sessions (contact time 3 hours, 200 participants).

1997 State of the Art Lecture. The endothelial function in the

microcirculation of the diabetic foot. American Diabetes Association, 57th Annual Scientific Sessions. Boston, MA. (contact time 30 minutes, 300 participants).

Diabetic Neuropathy: Evaluation and Management, and Endothelial Dysfunction and The Role of Microcirculation Abnormalities in Healing Problem of Diabetic Wounds. At: The Diabetic Foot. Update 1997: A multidisciplinary approach. Dept of Orthopaedics, The University of Texas Health Science Center at San Antonio, Texas. CME Course (contact time 40 minutes, 300 participants).

Baropodometric Evaluation of the Diabetic Foot, Pathology of the Diabetic Foot. At: XVII Congress of the Latin American Rehabilitation Medical Association and XV Brazilian Congress of Physical Medicine and Rehabilitation. Sao Paulo, Brazil (contact time 2 hours, 400 participants).

1998 New treatments for foot ulcers. At: European Association for the Study of Diabetes, Postgraduate Course. Barcelona, Spain. (contact time 30 minutes, 300 participants).

Pathogenesis of foot ulceration. At: Advances in Wound Care meeting. Atlanta, GA (contact time 2 hours, 1000 participants).

Role of the Microcirculation and Advances in Vascular Medicine. At: VI Annual Symposium Critical Issues in Surgery. Wound healing: Science & Industry. Staten Island University Hospital, Research and Clinical Technology. St. Thomas, US Virgin Islands, (contact time 20 minutes, 80 participants).

1999 Workshop. Assessment of risks factors for foot

ulceration. At: 46th Annual Postgraduate Course of the American Diabetes Association, Orlando, FL. (contact time 30 minutes, 200 participants). Role of Microcirculation in Wound Healing. Consensus Development Conference on Diabetic Foot Wound Care, organized by the American Diabetes Association. Boston, MA (contact time 20 minutes, 200 participants).. Vascular reactivity and microcirculation. American Diabetes Association 59th Annual Scientific Sessions. San Diego, CA. (contact time 30 minutes, 600 participants). New advances in treating diabetic foot ulcers: Experience at Deaconess-Joslin Foot Center. Industry sponsored symposium: New concepts in the management of diabetic foot ulcers. American Diabetes Association 59th Annual Scientific Sessions. San Diego, CA. (contact time 30 minutes, 200 participants). Chairman of the symposium. Consideration for the infected diabetic foot ulcer. Emerging antibiotic therapy. Industry sponsored symposium. American Diabetes Association 59th Annual Scientific Sessions. San Diego, CA. June 1999 (contact time 20 minutes, 300 participants). Clinical experience with tissue engineered skin in diabetic foot ulcers. Industry sponsored symposium: Advanced therapy for difficult to heal wounds. 3rd Joint

meeting of The European Tissue Repair Society & Wound Healing Society. Bordeaux, France. August 1999 (contact time 20 minutes, 400 participants). Advances in Diabetic Foot Ulcers: An update from a pivotal trial. Industry sponsored symposium: New Approaches in Wound Healing: Novel Surgical Techniques and Advances in Tissue Engineering. 85th annual meeting, American College of Surgeons. San Francisco, October 1999 (contact time 20 minutes, 300 participants). Tissue Engineering: Apligraf. At: The Diabetic Foot. Update 1999: A Multidisciplinary Approach. Dept of Orthopedics, The University of Texas Health Science Center at San Antonio, Texas. (contact time 30 minutes, 250 participants).

2000 The role of microcirculation and bioengineered skin in

the treatment of the diabetic foot. At: New Vascular Horizons and management of the diabetic foot and wound healing. Louisiana Podiatric Medical Association, New Orleans. (contact time one hour, 300 participants). Evaluation of a Human Skin Equivalent for the treatment of diabetic foot ulcers in a prospective, randomized clinical trial. At: Austrian Wound Association first annual meeting. Vienna, Austria. (contact time 20 minutes, 200 participants). Diabetic Neuropathy At: Endocrine Society of Oklahoma City, Oklahoma. (contact time 1 hour, 30 participants).

Diabetic Neuropathy At: Medical Grand Round, University of Massachusetts, Medical Center. (contact time 1 hour, 100 participants).

The use of Apligraf in the treatment of diabetic foot ulceration. At: The Diabetic Foot International Meeting. Malvern, UK. (contact time 20 minutes, 200 participants).

Living skin equivalents. American Diabetes Association 60th Annual Scientific Sessions. San Antonio, TX. (contact time 30 minutes, 400 participants).

New directions in the management of diabetic foot ulcers: Advances in Diabetic Foot Care: Utilization of

Bioengineered Skin. Industry sponsored symposium: New concepts in the management of diabetic foot ulcers. American Diabetes Association 60th Annual Scientific Sessions. San Antonio, TX. (contact time 20 minutes, 200 participants). Endothelial function in diabetic neuropathy. Joint symposium – Neurodiab/Diabetic Foot Study Group, European Association for the Study of Diabetes. Rome, Italy. (contact time 30 minutes, 150 participants).

2001 Neuropathy: New concepts in Evaluation and treatment. Joint educational program by American Diabetes Association and American Podiatric Medical Association. Orlando, FL. (contact time 20 minutes, 300 participants). Diabetic Neuropathy At: Medical Grand Round, University of Arkansas for Medical Sciences. (contact time one hour, 100 participants). A comparison of a new topical treatment, Promogran® versus standard treatment in the management of diabetic foot ulcers. German Wound Healing Society. Ulm, Germany (contact time 20 minutes, 200 participants). Role of Microcirculation in Wound Healing. Wound Healing: Science and Industry. St. Thomas, VI. (contact time 20 minutes, 50 participants). Vascular Reactivity Changes in Diabetes and Pre-Diabetes. Joslin Diabetes Center, Boston, MA. (contact time 1 hour, 80 participants).

2002 Diabetic Neuropathy and Pain. Pain Center, Dept. of Anesthesia, Massachusetts General Hospital. (contact time 1 hour, 50 participants). Endothelial Function in Diabetes and Pre-Diabetes. Juvenile Diabetes Research Foundation Center on Diabetic Complications & The Center for Vascular and Lung Pathobiology at Columbia University, Columbia Presbyterian Hospital, New York, NY. (contact time 1 hour, 50 participants).

Pathogenesis of Diabetic Foot Ulceration. Boston University NeuroMuscular Research Center, Boston, MA. (contact time 1 hour, 30 participants). Diabetes Related Changes in the Skin Microcirculation. Implications for Wound Healing. At: New Frontiers in the Treatment of Type 1 Diabetes and its Complications. 7th Oxford Diabetes Workshop jointly organized by the European Association for the Study of Diabetes (EASD) and the Juvenile Diabetes Research Foundation International (JDRF). Keble College, Oxford, UK. (contact time 30 minutes, 50 participants). Pathogenesis of Diabetic Foot Ulceration (Keynote speaker). At Saitama Diabetic Complication Workshop 2002. "Learn from Overseas Diabetic Treatment", Saitama, Japan (contact time 1 hour, 450 participants). Pathogenesis of Diabetic Foot Ulceration (Keynote speaker). At Chiba Diabetic Complication Workshop 2002. "Learn from Overseas Diabetic Treatment", Chiba, Japan (contact time 1 hour, 350 participants). New Insights into the Pathogenesis of Atherosclerosis. At Contemporary Issues In Atherosclerosis: Focus On The Science. Organized by Pfizer Inc., (contact time 1 hour, 15 participants). Prof. M. Viswanathan Lecture: Diabetic Foot Problems. At Chennai Diabetes Research Centre Gold Medal Oration Award. Chennai, India (contact time 1 hour, 300 participants). Microcirculation Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. (contact time 30 min, 80 participants).

2003 Neuropathy and Microvascular Disease. At Symposium on Advanced Wound Care. Las Vegas. (contact time 30 minutes, 1500 participants). Endothelial Dysfunction and the Microcirculation. At the Consensus Development Conference on PVD in Diabetes, organized by the American Diabetes Association. (contact time 40 minutes, 150 participants).

Diabetes and Cardiovascular Disease. At Renal Division Seminar Conferences,, Medical Center of University of Vermont. (contact time 60 minutes, 25 participants). Skin Microcirculation and Wound Healing. At Wound Healing Workshop, organized by DARPA, NIH (NIDDK, NIGM) and Juvenile Diabetes Research Foundation. Annapolis MD, September 2003. (contact time 20 minutes, 50 participants).

The role of Microcirculation in Diabetic Foot Pathology. At Diabetic Foot Management. Harvard Medical School. Boston, MA, November 2003 (contact time 20 minutes, 250 participants). New Concepts in Skin Microcirculation Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2003 (contact time 30 minutes, 80 participants).

2004 Endothelial dysfunction in diabetes. 5th Boston Vascular Fellows Basic Science Seminar. Boston, January 2004 (contact time 60 minutes, 15 participants). Endothelial function in the microcirculation in diabetes. Elli Lilly and Company. Indianapolis, Indiana, March 2004 (contact time 60 minutes, 20 participants). Vascular And Metabolic Changes In The Diabetic Foot. (RFA HL-03-003) "Clinical Research in Peripheral Arterial Disease " Grantees' Meeting, Bethesda, MD, March 2004. (contact time 30 minutes, 30 participants). Roger Pecoraro Lecture. American Diabetes Association 64th Annual Scientific Sessions. Orlando, FL, June 2004, (contact time 45 minutes, 300 participants).

Microvascular Dysfunction in the Diabetic Foot. Is It Clinically Significant? At: New Cardiovascular Horizons and management of the diabetic foot and wound healing. Louisiana Podiatric Medical Association, New Orleans, LA, October 2004. (contact time 30 minutes, 500 participants). The role of Microcirculation in Diabetic Foot Pathology. At Diabetic Foot Management. Harvard Medical School.

Boston, MA, November 2004 (contact time 30 minutes, 200 participants). Vascular Abnormalities in the Diabetic Foot. At: The Diabetic Foot. Update 2004: A Multidisciplinary Approach. Dept of Orthopedics, The University of Texas Health Science Center at San Antonio, Texas, December 2004. (contact time 30 minutes, 250 participants). Skin Microcirculation Abnormalities in Diabetes. Wound Healing: Science and Industry. St. Thomas, VI. December 2004 December 2004. (contact time 30 minutes, 75 participants).

Future Lectures

2005 Vascular Abnormalities and Wound Healing. Diabetic Vascular Disease and Wound Complications. European Tissue Repair Society and Vascular Medicine Research Group, University of Southampton, UK, March 2005. Diabetes and Vascular Disease. Nine Congress Of Vascular Problems, Risk Factor And Diabetic Foot. Buenos Aires, Argentine, May 2005

b. Professional and educational leadership

1998 Member of the Organizing Committee of Advances in Wound Care Meeting. Atlanta, GA. This is a multidisciplinary conference devoted exclusively to the management of wounds. The main goal is to help practitioners involved in wound care learn how to translate the concept of "quality" into clinical decision making that can have a positive effect on practice-and a measurable impact on outcomes of patient care.

1999 Planning Committee member of the Consensus

Development Conference on Diabetic Foot Wound Care, organized by the American Diabetes Association. The main goal of this meeting was to develop a consensus that will help in the management of diabetic foot ulcers.

2001- Meeting Committee member of Wound Healing: Science and Industry. St. Thomas, VI. This is an interdisciplinary meeting that allows opinion leaders to discuss and interact with various professionals in academics and industry.

2001. American Diabetes Association Expert Committee on Foot Wound Classification, member

2002. Planning Committee member of the Consensus Development Conference on PVD in Diabetes, organized by the American Diabetes Association. The main goal of this meeting was to develop a consensus that will help in the management of peripheral vascular disease in the diabetic foot.

BIBLIOGRAPHY Original Reports

1. Veves A, Masson EA, Fernando DJS, Boulton AJM: The use of experimental hosiery to reduce plantar foot pressures in diabetic neuropathy. Diabetes Care 9 : 653 -655, 1989

2. Masson EA, Veves A, Fernando DJS, Boulton AJM. Current perception thresholds: A new quick and reproducible method of assessing peripheral nerve function in diabetes mellitus. Diabetologia 32: 724 - 728, 1989

3. Masson EA, Hay EM, Stockley I, Veves A, Betts R, Boulton AJM. Abnormal foot pressures alone may not cause ulceration. Diabetic Medicine 6: 426-428, 1989

4. Veves A, Masson EA, Fernando DJS, Boulton AJM. Studies of experimental hosiery in diabetic patients with high foot pressures. Diabetic Medicine 7: 324-326, 1990;

5. Fernando DJS, Masson EA, Veves A, Boulton AJM. Limited Joint Mobility: Relationship to abnormal foot pressures and diabetic foot ulceration. Diabetes Care 14: 8-11, 1991

6. Veves A, Fernando DJS, Walewski P, Boulton AJM. A study of plantar pressures in a diabetic clinic population. The Foot 1: 89-92, 1991

7. Fernando DJS, Hutchison A, Veves A, Gokal R, Boulton AJM. Risk factors for non-ischaemic foot ulceration in diabetic nephropathy. Diabetic Medicine 8: 223-225,1991

8. Thomson FJ, Veves A, Ashe H, Knowles EA, Gem J, Walker MG, Hirst P, Boulton AJM. A team approach to diabetic foot care - the Manchester experience. The Foot 1: 75-82, 1991

9. Kumar S, Fernando DJS, Veves A, Knowles EA, Young MJ, Boulton AJM. Semmes-Weinstein monofilaments: a simple, effective and inexpensive screening

device for identifying diabetic patients at risk of foot ulceration. Diabetes Research and Clinical Practice 13: 63-67, 1991

10. Dent MT, Veves A , Tebbs SE, Gonzalez AM, Malik RA, Boulton AJM, Ward JD, Wilson RM. Neutrophil aldose reductase activity as a potential marker for neuropathy and cataract in diabetes. Diabetic Medicine 8: 911-916, 1991

11. Veves A, Malik RA, Lye RH, Masson EA, Sharma AK, Schady W, Boulton AJM. Correlations between sural nerve histology and electrophysiology and quantitative sensory tests in mild diabetic neuropathy. Diabetic Medicine 8: 917-921, 1991

12. Veves A, Hay EM, Boulton AJM. The use of specially padded hosiery in the painful rheumatoid foot. The Foot 1: 175-177, 1992

13. Malik RA, Veves A, Masson EA, Sharma AK, Ah-See AK, Schady W, Lye RH, Boulton AJM. Endoneurial capillary abnormalities in early human diabetic neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 55: 557-561, 1992

14. Veves A, Van Ross ERE, Boulton AJM. Foot pressure measurements in diabetic and non-diabetic amputees. Diabetes Care 15: 905-907, 1992

15. Veves A, Boulton AJM. Measuring subjective symptoms. (Letter to the editor). Diabetes Care 15: 1434, 1992

16. Veves A, Murray HJ, Young MJ, Boulton AJM. The risk of foot ulceration in diabetic patients with high foot pressure: A prospective study. Diabetologia 35: 660-663, 1992

17. Young MJ, Veves A, Walker MG, Boulton AJM. Correlations between nerve function and tissue oxygenation in diabetic patients: further clues to the aetiology of diabetic neuropathy. Diabetologia 35: 1146-1150, 1992

18. Young MJ, Murray HJ, Veves A, Boulton AJM. A comparison of the Musgrave Footprint and Optical Pedobarograph systems for measuring dynamic foot pressures in diabetic patients. The Foot 3:62-64, 1993

19. Malik RA, Tesfaye S, Thompson SD, Veves A, Sharma AK, Boulton AJM, Ward JD. Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia 36: 454-459, 1993

20. Murray HJ, Veves A, Young MJ, Richie DM, Boulton AJM. The role of experimental socks in the care of the high risk diabetic foot: a multicentre patient evaluation study. Diabetes Care 16: 1190-1192, 1993

21. Veves A, Manes C, Murray HJ, Young MJ, Boulton AJM. Painful neuropathy in diabetic patients with or without foot ulceration. Diabetes Care 16: 1187-1189, 1993

22. Young MJ, Breddy JL, Veves A, Boulton AJM. The prediction of diabetic foot ulceration using vibration thresholds: A prospective study. Diabetes Care 17: 557-560, 1994

23. Veves A, Uccioli L, Manes C, Van Acker K, Komninou H, Philippides P, Katsilambros N, De Leeuw I, Menzinger G, Boulton AJM. Comparisons of risk factors for foot problems in diabetic patients attending teaching hospitals outpatient clinics in four different European states. Diabetic Medicine 11: 709-713, 1994

24. Veves A, Webster L, Chen TF, Payne S, Boulton AJM. Aetiopathogenesis and management of impotence in diabetic males: Four years experience from a combined clinic. Diabetic Medicine 12: 77-82, 1995

25. Sarnow MR, Veves A, Giurini JM, Rosenblum BI, Chrzan JS, Habershaw GM. In-shoe foot pressure measurements in diabetic patients with at risk feet and healthy subjects. Diabetes Care 17: 1002-1006, 1994

26. Veves A, Young MJ, Manes C, Boulton AJM. Differences in peripheral and autonomic nerve function measurements in painful and painless neuropathy: A clinical study. Diabetes Care 17: 1200-1203, 1994

27. Malik RA, Tesfaye S, Thompson SD, Veves A, Hunter A, Sharma AK, Ward JD, Boulton AJM. Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. Microvascular Research 1994; 48: 236-245

28. Veves A, Sarnow MR, Giurini JM, Rosenblum BI, Lyons TE, Chrzan JS, Habershaw GM. Differences in joint mobility and foot pressures between black and white diabetic patients. Diabetic Medicine 1995; 12: 585-589

29. Donaghue VM, Giurini JM, Rosenblum BI, Weissman PN, Veves A. Variability in function measurements of three sensory foot nerves in neuropathic diabetic patients. Diabetes Research and Clinical Practice 1995; 29: 37-42

30. Young MJ, Veves A, Smith JV, Walker MG, Boulton AJM. Restoring lower limb blood flow improves conduction velocity in diabetic patients. Diabetologia 1995; 38: 1051-1054

31. Veves A, Donaghue VM, Sarnow MR, Giurini JM, Campbell DR, LoGerfo FW. The Impact of Reversal of Hypoxia by Revascularization In The Peripheral Nerve Function of Diabetic Patients. Diabetologia 1996; 39:344-348

32. Donaghue VM, Sarnow MR, Giurini JM, Chrzan JS, Habershaw GM, Veves A. Longitudinal In-Shoe Foot Pressure Relief Achieved by Specially Designed Footwear in High Risk Diabetic Patients. Diabetes Research and Clinical Practice 1996; 31: 109-114

33. Akbari CM, Gibbons GW, Habershaw GM, LoGerfo FW, Veves A. The Effect of Arterial Reconstruction on the Natural History of Diabetic Neuropathy. Archives of Surgery 1997: 132; 148-152

34. Young MJ, Bennett JL, Liderth SA, Veves A, Boulton AJM, Douglas JT. Rheological and microvascular parameters in diabetic peripheral neuropathy. Clinical Science 1996; 90:183-7

35. Frykberg RG, Piaggesi A, Donaghue VM, Schipani E, Habershaw GM, Navalesi R, Veves A. Outcome Variation of Foot Ulcer Treatment in Two Different Centers. Diabetes Research and Clinical Practice 1997; 35: 21-26

36. Veves A, Saouaf R, Donaghue VM, Mullooly CA, Kistler JA, Giurini JM, Horton ES, Fielding RA. Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients. Diabetes 1997; 46: 1846-1852

37. Donaghue VM, Chrzan JS, Rosenblum BI, Giurini JM, Habershaw GM, Veves A. A clinical evaluation of a collagen-alginate topical wound dressing (FIBRACOL* Dressing) in the management of diabetic foot ulcers. Advances in Wound Care 1998; 11:114-117

38. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease and foot ulceration. Diabetes 1998;47:457-463

39. Arora S, Veves A, Caballero AE, Smakowski P, LoGerfo FW. Estrogen improves endothelial function. Journal of Vascular Surgery 1998; 27:1141-47

40. Saouaf R, Arora S, Smakowski P, AE Caballero, Veves A. Reactive hyperemic response of the brachial artery to proximal and distal occlusion. Academic Radiology 1998;5:556-560

41. Arora S, Smakowski P, Frykberg RG, Freeman R, LoGerfo FW, Veves A. Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy. Diabetes Care 1998;21:1339-44

42. Frykberg RG, Lavery LA, Pham H, Harvey C, Harkless L, Veves A. The risk of ulceration in diabetic patients with high foot pressures and neuropathy. Diabetes Care 1998;21:1714-1719

43. Akbari CM, Saouaf R, Barnhill DF, Newman PA, LoGerfo FW, Veves A: Endothelium-Dependent Vasodilatation is Impaired in Both Micro- and Macrocirculation During Acute Hyperglycemia. Journal of Vascular Surgery 1998;28:687-694

44. Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Micro- and macro-vascular reactivity is impaired in subjects at risk for type 2 diabetes. Diabetes 1999:48:1863-1867

45. Pham HT, Rosenblum BI, Lyons TE, Giurini JM, Chrzan JS, Habershaw GM, Veves A. Evaluation of Graftskin (Apligraf®), a Human Skin Equivalent, for the Treatment of Diabetic Foot Ulcers in a Prospective, Randomized, Clinical Trial. Wounds 1999;11:79-86

46. Lim SC, Caballero AE, Arora S, Smakowski P, Bashoft E, Brown F, LoGerfo FW, Horton ES, Veves A. The effect of gender and hormonal replacement therapy on the vascular reactivity of healthy individuals and individuals with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 1999;84: 4159-4164

47. Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES, Veves A. Soluble Intercellular Adhesion Molecule (ICAM), Vascular Cell Adhesion Molecule (VCAM) and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes Care 1999;22:1865-1870

48. Pham HT, Armstrong DG, Harvey C, Harkless LB, Giurini JM, Veves A. Screening techniques to identify the at risk patients for developing diabetic foot ulcers in a prospective multicentre trial. Diabetes Care 2000;23:606-611

49. Malik RA, Veves A, Walker D, Lye RH, Schady W, Boulton AJM. Sural nerve fibre pathology in diabetic patients with mild neuropathy: Relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology. Acta Neuropathologica 2001;101:367-374

50. Rich J, Veves A. Forefoot and Rearfoot Plantar Pressures in Diabetic Patients: Correlation to Foot Ulceration. Wounds 2000;12:82-87

51. Hamdy O, Abou-Elenin A, LoGerfo FW, Horton FW, Veves A. The contribution of nerve axon reflex-related vasodilation to the total endothelium-dependent vasodilation in the skin of diabetic patients with and without neuropathy. Diabetes Care 2001;24:344-349

52. Veves A, Falanga V, Armstrong DG, Sabolinski ML, for the Apligraf Diabetic Foot Ulcer Study. Graftskin, a human skin equivalent, is effective in treating diabetic foot ulcers in a prospective, randomized, multicenter clinical trial. Diabetes Care 2001;24:290-295

53. Arora S, Pomposelli F, LoGerfo FW, Veves A. Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization. Journal of Vascular Surgery 2002;35:501-505

54. Abou-Elenin A, Antonios Xydakis A, Hamdy O, Economides PA, Horton ES, Veves A. The effect of aspirin and various iontophoresis solution vehicles in skin microvascular reactivity. Microvascular Research 2002;63:91-5

55. Epstein FH, Veves A, Prasad P. Effect of diabetes mellitus on renal medullary oxygenation during water diuresis. Diabetes Care 2002 25: 575-578

56. Veves A, Sheehan P, Pham TH. A comparison of a new topical treatment, Promogran® versus standard treatment in the management of diabetic foot ulcers Archives of Surgery 2002;137:822-7

57. Caselli A, Pham Ht, Giurini JM, Armstrong DG, Veves A. The forefoot / rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration. Diabetes Care 2002 25: 1066-1071

58. Pham HT, Exelbert L, Segal-Owens AC, Veves A. A Prospective Randomized Controlled Double-Blind Study of a Moisturizer Containing 10% Urea and 4% Lactic Acid Versus the Vehicle for Xerosis of the Feet in Subjects with Diabetes. Ostomy Wound Management 2002;48:30-36

59. Caselli A, Singh Bedi D, O’Connor C, Shah C, Veves A. Assessment of Laser Perfusion Imager’s in vivo Reliability: Can it be used for a prospective analysis? Journal of Laser Applications 2002;14:198-202

60. Caballero AE, Saouaf R, Lim SC, Hamdy O, Abou-Elenin K, O’Connor K, LoGerfo FW, Horton ES, Veves A. The effects of troglitazone, an insulin sensitizing agent, on the endothelial function in early and late type 2 diabetes. A placebo-controlled, randomized, clinical trial. Metabolism 2003;52:173-180

61. Szabó C, Zanchi A, Komjáti K, Pacher P, Krolewski AS, Quist WC, LoGerfo FW, Horton ES, Veves A. Poly (ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 2002;106:2680-2686.

62. Caselli A, Rich J, Hanane T, Uccioli L, Veves A. Role of c-nociceptive fibers in the impairment of nerve axon reflex-related vasodilation in diabetes. Neurology 2003;60:297-300.

63. Caselli A, Hanane T, Brady J, Carter S. Khaodhiar L, Veves A. Methyl Nicotinate-Induced Skin Vasodilation In Diabetic Neuropathy. Journal of Diabetes and it Complications 2003;17:205-10.

64. Sheehan P, Jones P, Caselli A, Giurini JM, Veves A. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes Care 2003;26:1879-82

65. Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Ceselli A, Caballero AE, Economides PA, Veves A, Horton ES. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care, 2003: 26;2119-2125

66. Varo N, Vicent D, Libby P, Nuzzo R, Calle-Pascual AL, Bernal MR, Fernández-Cruz A, Veves A, Jarolim P, Varo JJ, Goldfine A, Horton ES, Schönbeck U.

Elevated plasma levels of the atherogenic mediator sCD40L in diabetic patients: a novel target of thiazolidinediones? Circulation, 2003;107:2664-9

67. Caselli A, Uccioli L, Khaodhiar L, Veves A. Local anesthesia reduces the maximal skin vasodilation during iontophoresis of sodium nitroprusside and heating. Microcirculation Research 2003;66:134-139

68. Economides PA, Caselli A, Zuo CS, Khaodhiar L, Sparks C, Katsilambros N, Horton ES, Veves A. Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetes. Metabolism 2004;53:222-27

69. Khaodhiar L, Niemi JB, Harry LD, Earnest R, Lima C, Veves A. Enhancing sensation in diabetic neuropathic foot with mechanical noise. Diabetes Care 2003 26: 3280-83

70. Economides PA, Caselli A, Tiani E, Khaodhiar L, Horton ES, Veves A. The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetes. Diabetes. Journal of Clinical Endocrinology & Metabolism, 2004;89:740-7.

71. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 2004;27:2450-7

72. Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell S, King GL, Johnstone MT, Horton ES, Veves A. The effect of vitamin E on the endothelial function of the micro- and macro-circulation and the left ventricular function of type 1 and 2 diabetic patients. Diabetes 2005; 54:204-211

Submitted for Publication

1. O’Neill MS, Veves A, Zanobetti A, Sarnat JA, Gold DR, Economides PA, Horton ES, Schwartz J. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation

2. Priplata AA, Patritti BL, Niemi JB, Hughes R, Gravelle DC, Lipsitz LA, Veves A, Stein J, Bonato P, Collins JJ. Vibrating insoles and enhanced balance control in patients with diabetic neuropathy and patients with stroke. Neurology

3. Buras J, Reenstra WR, Orlow D, Horton ES, Veves A. Changes in adiponectin levels related to treatment with troglitazone do not affect endothelial function in type 2 diabetes. Obesity Research

4. Greenman RL, Khaodhiar L, Lima C, Dinh T, Giurini JM, Veves A. Foot Small Muscle Atrophy Precedes The Development Of Clinical Neuropathy. Diabetes

5. Caselli A, Spallone V, Marfia GA, Battista C, Pachatz C, Veves A, Uccioli L. Validation Of The Nerve Axon Reflex For The Assessment Of Small Nerve Fibers’ Dysfunction. Diabetes Care

6. Shrikhande G, Scali S, Lima C, Hubbard M, Dudley K, Csizmadia E, LoGerfo FW, Ganda O, Giurini JM, Ferran C, Veves A. Valsartan Improves Resting Skin Blood Flow In Type 2 Diabetic Patients And Reduces PARP Activation.

Reviews

1. Veves A and Boulton AJM: Commentary. Diabetes Spectrum 6: 336-337, 1992

2. Veves A and Boulton AJM: Editorial: An optimistic message for foot problems in diabetes. The Western Journal of Medicine 158: 78-79, 1993

3. Veves A and Boulton AJM: The optical pedobarograph. Clinics in Podiatric Medicine and Surgery 10: 463-470, 1993

4. Veves A and Boulton AJM: Diabetic foot: Diagnostic considerations. IDF Bulletin 38: 10-13, 1993

5. Veves A and Boulton AJM: The importance of documenting diabetic neuropathy. Treating Diabetes, Australia edition, 10: 3-8, 1992

6. Young MJ, Veves A and Boulton AJM: The Diabetic Foot. Diabetes and Metabolism Reviews 9: 109-127, 1993

7. Veves A, Manes C and Boulton AJM: Diabetic neuropathy. Hellenic Diabetological Chronicle 5: 1-8, 1992

8. Veves A and Boulton AJM: Comment, Clinical Diabetes 11: 38-39, 1993

9. Veves A and Sarnow MR: Diagnosis, classification and treatment of diabetic peripheral neuropathy. Clinics in Podiatric Medicine and Surgery 12:19-30, 1995

10. Veves A and Donaghue VM: Review of the Neurometer CPT Quantitative Sensory Nerve Tester. Journal of Clinical Neurophysiology 12: 197, 1995

11. Donaghue VM and Veves A: Foot Pressure Measurements. Orthopaedic Physical Therapy Clinics of North America 6: 1-16, 1997

12. Frykberg RG and Veves A: Diabetic Foot Infections. Diabetes and Metabolism Reviews 12: 255-270, 1996

13. Simeone LR and Veves A: Screening techniques to identify the diabetic patient at risk of ulceration. Journal of American Podiatric Medical Association 87: 1-5, 1997

14. Pham H, Economides PA and Veves A: The role of endothelial function on the foot microcirculation and wound healing in diabetic patients. Clinics in Podiatric Medicine and Surgery 15: 85-94, 1998

15. Pham H, Rich J, Veves A. Wound Healing in Diabetic Foot Ulceration. Wounds 2000;12: 79-82

16. Economides PA, Veves A. Etiopathogenesis of Foot Ulceration in Diabetes. Wounds 2000;12 (Suppl B): 1B-6B

17. Veves A, King GL. Can VEGF reverse diabetic neuropathy in human subjects? Journal of Clinical Investigation 2001;107;1215-1218

18. Rich J, Pham HT, Veves A. Living Skin Equivalents - Changing Trend for Diabetic Foot Ulceration. Lower Limb Wounds 2002;1:27-31

19. Dinh D, Pham HT, Veves A. Emerging Treatments in Diabetic Wound Care. Wounds 2002, 14: 2-10

20. Hile C, Veves A. Diabetic Neuropathy and Microcirculation. Current Diabetes Reports 2003;3:446-51.

21. Dinh D, Veves A. Microcirculation in the diabetic foot: An Update. International Journal for Lower Extremity Wounds, 2004; 3: 60-61

22. Dinh T, Veves A. Microcirculation of the Diabetic Foot. Current Pharmaceutical Design (In Press)

23. Skljarevski V, Veves A. Impact of Diabetes on Vasculature – Focus on Nervous System. Current Diabetes Reviews (In Press)

Chapters in books

1. Veves A and Boulton AJM. Treatment of diabetic neuropathy. In: Sharma AK, Galadari I, Abdulrazzaq Y, Behara M, Mehra NK and Manchanda SK (Eds). Diabetes Mellitus and its complications - an update. Vedams Books International, New Delhi 1993

2. Veves A and Boulton AJM. Tolrestat. In: Dollery CT (Ed). Therapeutic Drugs: Supplement 1. Churchill Livingstone, Edinburgh, 1992, pp 206-210

3. Boulton AJM, Veves A and Young MJ. Etiopathogenesis and management of abnormal foot pressures. In: Levin ME, O'Neal LW, Bowker JH (Eds). The Diabetic Foot, 5th Edition. Mosby, St Louis, 1993, pp 233-246

4. Veves A and Boulton AJM. Diabetic neuropathy: The diabetologist's view. In: Horrobin D (Ed). Treatment of Diabetic Neuropathy A New Approach. Churchill Livingstone, Edinburgh 1992, pp 1-10

5. Malik RA, Tesfaye S, Veves A, Sharma AK, Ward JK, Boulton AJM: The progression of microangiopathy with neuropathic severity. In: Hotta N, Greene DA, Sima AAF,

Boulton AJM: Diabetic Neuropathy. New Concepts and Insights. Excepta Medica, Elsevier, Amsterdam, 1996, pp 131-135.

6. Veves A: Diagnosis of diabetic neuropathy. In Veves A: The Clinical Management of Diabetic Neuropathy. Humana Press, Totowa, NJ, 1998, pp 61-75

7. Veves A: Aldose reductase inhibitors. In Veves A: The Clinical Management of Diabetic Neuropathy. Humana Press, Totowa, NJ, 1998, pp 121-132

8. Caballero AE, Lim SC, Horton ES, Veves A. Vascular abnormalities in the prediabetic stage. In: Johnstone MT, Veves A: Diabetes and Cardiovascular Disease. Humana Press, Totowa, NJ, 2001, pp65-80

9. Hamdy O, Abou-Elenin K, Veves A. Microcirculation of the diabetic foot. In: Johnstone MT, Veves A: Diabetes and Cardiovascular Disease. Humana Press, Totowa, NJ, 2001, pp 431-446

10. Lyons TE, Rich J, Veves A. Foot pressure abnormalities in the diabetic foot. In: Veves A, Giurini JM, LoGerfo FW: The Diabetic Foot: Medical and Surgical Management. Humana Press, Totowa, 2002, pp 127-146

11.Pham HT, Veves A. Living skin equivalents for the diabetic foot ulcer. In: Veves A, Giurini JM, LoGerfo FW: The Diabetic Foot: Medical and Surgical Management. Humana Press, Totowa, NJ, 2002, pp 397-410

12.Veves A, Caselli A, Economides PA. New therapies for the treatment of diabetic neuropathy. In: Barnett AH: Diabetes Annual 2002. Martin Dunitz, London, UK. 2002, pp 185-207

13.Cotter MA, Veves A, Tesfaye S, Cameron NE. Nerve Blood Flow. In: Gries A, Ziegler D, Low P, Cameron NE. Diabetic Neuropathy, Thieme, Stuttgart, Germany, 2002, pp 115-123

14.T Dinh, Veves A. The Diabetic Foot. In: DeFronzo RA, Ferrannini E, Keen H, Zimmet P. International Textbook of Diabetes Mellitus, 3rd edition. John Wiley & Sons, Chichester, England, 2004, pp 1315-1332

15.Khaodhiar L, Veves A. Therapeutic Interventions to Improve Endothelial Function in Diabetes. In: Johnstone MT, Veves A: Diabetes and Cardiovascular Disease (second edition). Humana Press, Totowa, NJ. (In Press)

16.Hile C, Veves A. Microcirculation of the Diabetic Foot. In: Johnstone MT, Veves A: Diabetes and Cardiovascular Disease (second edition). Humana Press, Totowa, NJ. (In Press)

17.Dinh T, Veves A. Microcirculation of the Diabetic Foot. . In: Mantzoros C: Obesity and Diabetes. Humana Press, Totowa, NJ. (In Press)

Editorship in books

1. Veves A: The Clinical Management of Diabetic Neuropathy. Humana Press, Totowa, NJ, June 1998

2. Johnstone MT, Veves A: Diabetes and Cardiovascular Disease. Humana Press, Totowa, NJ, April 2001

3. Veves A, Giurini JM, LoGerfo FW: The Diabetic Foot: Medical and Surgical Management. Humana Press, Totowa, NJ, March 2002

4. Johnstone MT, Veves A: Diabetes and Cardiovascular Disease. Second Edition Humana Press, Totowa, NJ. In Preparation, estimated day of release, January 2005

5. Veves A, Malik RA: The Clinical Management of Diabetic Neuropathy. Second Edition Humana Press, Totowa, NJ. In Preparation, estimated day of release, June 2005

6. Veves A, Giurini JM, LoGerfo FW: The Diabetic Foot: Medical and Surgical Management. Second Edition Humana Press, Totowa, NJ. In Preparation, estimated day of release, September 2005

Editorship in Supplements

1. Veves A, Falanga V. Diabetic Foot Ulcers: Prevention and Treatment. Wounds 2000;12: Supplement B

Date prepared: 11/1/2004

CURRICULUM VITAE Name: John Mario Giurini, D.P.M. Address: Office - 1 Deaconess Road Boston, Mass. 02215 (617) 632-8428 fax: (617) 632-7090 jgiurini@bidmc.harvard.edu Home - 5 Fairview Road Medfield, Mass. 02052 (508) 359-4557 fax: (508) 359-9980 jgiurini@comcast.net Date of Birth: January 28, 1954 Place of Birth: Rome, Italy Citizenship: U.S.A. Education and Training: Education: 1976 B.A. University of California, Los Angeles 1978 B.S. Calif. State Univ., Dominguez Hills 1983 D.P.M. Calif. College of Podiatric Medicine B.S. Postdoctoral Training: Internship and Residency: 1983 - 1984 Intern in Podiatry Deaconess Hospital Boston, Mass. 1984 - 1985 Senior Resident in Podiatry Deaconess Hospital Boston, Mass. Fellowship: 1986 - 1987 Clinical Research, Diabetic Foot Problems Department of Surgery Deaconess Hospital Boston, Mass.

Licensure and Certification: 1983 Massachusetts license, Reg. #1690 1985 California license, Reg. #E3311 1988 American Board Podiatric Surgery, Cert. #1885 (recertified in 1997) Professional Appointments: Academic Appointments: 1985 - 1986 Clinical Assistant Professor L.A. County/U.S.C. Medical Center 1985 - 1986 Clinical Assistant Professor California College of Podiatric Medicine 1986 - 1995 Clinical Instructor in Surgery Harvard Medical School 1991 - Clinical Adjunct Faculty California College of Podiatric Medicine 1991 - Clinical Adjunct Faculty Pennsylvania College of Podiatric Medicine 1991 - Clinical Adjunct Faculty College of Podiatric Medicine & Surgery Des Moines, Iowa 1991 - Clinical Adjunct Faculty Barry University College of Podiatric Medicine Miami Shores, Florida 1995 - 2001 Assistant Clinical Professor of Surgery Harvard Medical School 2001 - Associate Clinical Professor of Surgery Harvard Medical School Hospital Appointments: 1986 - 1992 Allied Staff, Deaconess Hospital 1987 - Consultant, Joslin Diabetes Center 1987 - 1998 Active Staff, Leonard Morse Hospital 1988 - Consultant, Dana-Farber Cancer Institute 1990 - Active Staff, Quincy Hospital 1991 - Allied Staff, New England Baptist Hospital 1992 - 1996 Active Staff, Deaconess Hospital 1993 - 1998 Allied Staff, South Shore Hospital 1994 - 1998 Active Staff, Milford-Whitinsville Hospital 1995 - 1997 Allied Staff, Southwood Hospital

1996 - Consultant, Braintree Hospital Rehabilitation Network MetroWest Medical Center 1996 - 2000 Allied Staff, Children’s Hospital Medical Center 1996 - Active Staff, Beth Israel Deaconess Medical Center Other Professional Positions: 1989 - 1993 Consultant, Dept. of Biomedical Engineering Boston University 1992 Visiting Professor Division of Podiatry University Texas Health Science Center San Antonio, Texas 1993 Guest Editor, Journal American Podiatric Medical Assoc. 1998 Visiting Professor Pennsylvania College of Podiatric Medicine Philadelphia, Pennsylvania

2001 Visiting Professor West Penn Hospital Pittsburgh, Pennsylvania

Principal Clinical and Hospital Services Responsibilities: 1991 Library Committee, Member Deaconess Hospital 1991 - 1997 Surgical Case Review Committee, Member Deaconess Hospital 1992 - 1996 Resident’s Evaluation Committee, Member Division of Podiatry Deaconess Hospital 1996 - 2000 Resident’s Evaluation Committee, Chairperson Division of Podiatry Deaconess Hospital 1996 - 2000 Graduate Medical Education Committee, Member Beth Israel Deaconess Medical Center 2000 - O.R. Working Committee, Member Beth Israel Deaconess Medical Center 2000 - Podiatry/Vascular Volume Initiative Committee, Member Beth Israel Deaconess Medical Center Major Committee Assignments:

Local: 1989 Thesis Committee, Member Department of Biomedical Eng., Boston University National: 1991 - 2000 Examination Review Committee, Member National Board Podiatric Examiners

1994 - 1996 Committee on Research, Member American College of Foot & Ankle Surgeons 1995 Examination Committee, Oral Examiner American Board of Podiatric Surgery 1996 - Committee on Practice Guidelines, Member American College of Foot & Ankle Surgeons 1997 - 2000 Joint Residency Review Committee, On-site Evaluator Council of Podiatric Medical Education American Podiatric Medical Association 1998 - Committee on Diabetes, Member American College of Foot & Ankle Surgeons 1998 - Committee on Appeals Joint Residency Review Committee Council on Podiatric Medical Education 1998 - Committee on Diabetic Practice Guidelines, Member American College of Foot & Ankle Surgeons

1998 Planning Committee, Member 14th Annual Clinical Symposiium on Wound Care Wound Care Communications Network

1998 Scientific Program Planning Committee

ACFAS Annual Meeting

1999 Workshop Moderator ACFAS Annual Meeting

2000 - Research Committee, Board Liasion American College of Foot & Ankle Surgeons 2000 Journal Editorial Committee, Board Liasion American College of Foot & Ankle Surgeons 2000 Outcomes Research Committee, Member

American College of Foot & Ankle Surgeons 2000 - Nominations Committee, Member American College of Foot & Ankle Surgeons 2000 - Healthcare Management Guidelines Refinement Committee, Member American Podiatric Medical Association 2001 - Journal Managerial Committee, Board Liasion American College of Foot & Ankle Surgeons

2001 - Outcomes Research Committee, Board Liasion American College of Foot & Ankle Surgeons 2002 - Diabetes Foot Care Committee, Member Board of Registration in Podiatry, Massachusetts Major Administrative Responsibilities: 1986 - 1997 Director, Research & Fellowship Training Division of Podiatry Deaconess Hospital

1996 - 2000 Director, Podiatric Medical Education Division of Podiatry Beth Israel Deaconess Medical Center

1999 - Chief Division of Podiatry Beth Israel Deaconess Medical Center

1999 - Co-Director, Joslin – BI Deaconess Foot Center Beth Israeol Deaconess Medical Center

1999 - Chief Section of Podiatry New England Baptist Hospital Professional Society Involvement: Regional: 1983 - Massachusetts Podiatric Medical Society, Member 1987 American Diabetes Assoc., Mass. Affiliate Committee on Professional Education 1987 American Diabetes Assoc., Mass. Affiliate Committee on Program & Education 1995 Massachusetts Podiatric Medical Society Committee on Education National: 1979 - American Podiatric Medical Association, Member 1985 - 1986 California Podiatric Medical Society 1985 - 1986 Los Angeles County Podiatric Medical Society 1988 - American College of Foot & Ankle Surgeons, Fellow

1986 - American Diabetes Association Council on Diabetic Foot Care, Board of Directors 1987 American Diabetes Associaton Council on Diabetic Foot Care Committee on Membership, Chairman 1990 American Diabetes Association Council on Diabetic Foot Care Committee on Membership, Asst. Chairman 1993 American Diabetes Association Council on Diabetic Foot Care Committee on Practice Guidelines, Member

1995 European Assoc. for Study of Diabetes (EASD), Member 2000 - American College of Foot & Ankle Surgeons

Board of Directors Community Service: 1996 Health Fair Fenway Comm. Health Center/Northeastern Univ. Boston, Mass. 1997 Community Lecture YMCA of Greater Lawrence Lawrence, Mass. 1997 Health Fair Lotus Corporation Cambridge, Mass. 1997 Community Lecture Drury High School N. Adams, Mass. 2001 - Head Coach Medfield Youth Baseball Medfield, Mass. 2002 – 2004 Cub Scout Den Leader Pack 200 Medfield, Mass. 2002 - Volunteer Medfield Coalition Public Education Medfield, Mass. Editorial Boards:

1990 - Manuscript review board Journal American Podiatric Medical Association 1995 - Manuscript review panel Diabetes Care 1997 - Manuscript review panel Journal Foot & Ankle Surgery 1998 - 2000 Contributing Editor Journal American Podiatric Medical Association 2001 - Manuscript review panel New England Journal of Medicine Narrative Report:

Currently, I am the Chief of the Division of Podiatry at the Beth Israel Deaconess Medical Center. This position makes me responsible for all clinical, academic and research efforts of the division. Clinically, I supervise 6 other podiatric surgeons, 2 full-time researchers (MD/PhD) and 5 podiatric surgical residents. I also administer 7 sites of service. Cumulatively, these sites saw over 20,000 patient visits in the past fiscal year. Personally, I saw nearly 5,000 patient visits this past year.

Prior to becoming chief of the division, I served as the Director of Podiatric Medical Education. This encompasses the residency program, externship program for 4th year podiatric medical students and a monthly CME program for community podiatrists. During my tenure as director of podiatric medical education, the podiatric surgical residency program went from 1 resident/year for 2 years to 2 residents/year for 3 years. It went from a program that was placed on probation to a program that is fully accredited for 5 years and recognized as one of the top 3 or 4 programs in the country, providing comprehensive foot and ankle surgical training. In addition to the residency program, I also supervise an externship program for 4th year podiatric medical students. I have established affiliations with all 7 podiatric medical schools to allow their 4th year students the opportunity to spend a month at the BIDMC for the purposes of clinical training. This is a highly sought after rotation. Once a month the division holds a CME program for podiatrists. I also established a visiting professorship to promote academic interchange. As chief, I supervise the selection of the speakers and the visiting professor.

Prior to serving as the Director of Podiatric Medical Education, I served as the Director of Research and Fellowship Training. During my tenure I recruited an MD/PhD to help establish a center devoted to research on the diabetic foot. Today, that center has procured over $2 million dollars in grant support. While the majority of the research today is conducted under the guidance of Dr. Veves, I remain involved by reviewing and approving all grant proposals with Dr. Veves and serving as a mentor to the residents who are involved in these studies. Major Research Interests: 1. Reversal of hypoxic changes in diabetic patients following lower extremity revascularization. 2. Use of topical agents and dressings for treatment of neuropathic ulcerations. 3. Determining risk factors for foot problems in diabetic athletes. 4. Racial differences in joint mobility in diabetic patients and the risk of foot ulceration.

5. Genetic markers for the prediction of Charcot joint disease in diabetic patients. 6. Electrical bone stimulation for the treatment of Charcot joint disease. Research Funding: Past: 1. 1989 American Medical Electronics, Dallas, Texas. Principal Investigator. Evaluation of electrical bone stimulation for the treatment of severe Charcot joint disease. 2. 1993 Thor-Lo Hosiery, Statesville, North Carolina. Principal Investigator. Efficacy of preventive foot care in diabetic patients. 3. 1994 Johnson & Johnson Inc., Dallas, Texas . Co-investigator. A clinical evaluation of a collagen- alginate topical wound dressing in management of diabetic foot ulcerations. 4. 1994 Magainin Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania. Co-investigator. A

study comparing the efficacy of MSI-78 topical cream vs. oral Ofloxacin in the treatment of infected diabetic ulcers.

Current: 1. 2000 Organogenesis, Canton, Massachusetts. Principal Investigator. A controlled, randomized trial evaluating the efficacy of living skin equivalents in the treatment of diabetic foot ulcerations. Teaching Experience: Local Contributions: Undergraduate Courses: 1985 - 1986 L.A. County/U.S.C. Medical Center, Surgery Instructor; I provided monthly surgical instruction on cadaver specimens to 4th yr. podiatry students. Provided instruction to 3-4 students/month. Total instruction time: 36 hours/year.

1987 - American Association of College of Podiatric Medicine, Director of Podiatric Externship, Beth Israel Deaconess Medical Center; Direct and supervise a one month rotation in podiatry for 4th year podiatric medical students from the nation’s podiatry schools at the Medical Center. Provide supervision to two to three students/month or 20 students/year. Total instruction time: 12 hours/week or 600 hours/year.

1995 - 1996 Harvard Medical School, Ambulatory Care Clerkship; Directed by J. Carter, M.D., third-year HMS spent one day/week for one month in podiatry. As an attending, these students followed me in clinic while I interviewed and treated patients and discussed the patient’s pathology with the students. Provided instruction to 1-2 students/week each month. Total instruction time: 192 hours/year.

1999 - Harvard Medical School, Clinical Anatomy of Foot. Lectured to fourth-year HMS students on the anatomy of the foot and its use in everyday clinical practice. Provided lecture and dissection instruction to 6 students. Total instruction time: 6 hours/year.

Graduate Education: 1986 - Deaconess Hospital/Beth Israel Deaconess Medical Center, Resident Lecture Series; I am responsible for preparing and presenting monthly lectures to the podiatric residents and students. Provide instruction to 3 residents and 2 students. Total instruction time: 3 hours/month or 36 hours/year 1988 - 1990 Combined Boston Residency Program, Resident Lecture Series; I prepared and presented lectures to podiatric residents and students at the podiatric residency programs in the Boston area. I gave approximately 2 lecture/year to approximately 20 residents and students. Total instruction time: 8 hours/year.

1987 - 1997 Deaconess Hospital/Beth Israel Deaconess Medical Center, Director of Research & Fellowship Training, Division of Podiatry; In this position, it was my primary responbility to prepare research proposals and supervise fellows in the performance of this research. I also coordinated the preparation of manuscripts for publication and of abstracts for presentation at major scientific meetings. During my tenure as Director, our division became recognized as the leading authority on diabetic foot problems. During this time I either wrote or participated in the preparation of 18 original articles in peer review journals and the presentation of 18 abstracts at national and international meetings. Total instruction time: 6 hours/week or 300 hours/year.

1996 - Beth Israel Deaconess Medical Center, Director of Podiatric Medical

Education; As Director, I am responsible for coordinating rotation schedules, organizing a weekly lecture series and establishing new clinical rotations for 3 podiatric residents. This requires being familiar and abiding by the guidelines set by the Council on Podiatric Medical Education (CPME). I also serve as the chairperson of the Residency Evaluation Committee for Podiatry at the Medical Center. Total Time: 10 hours/week or 520 hours/year. 1997 - Endocrinology, Diabetes & Metabolism Fellows Rotation; Directed by M. Patti, M.D., Joslin endocrinology fellows and visiting fellows follow me in clinic while I interview and treat patients. I then discuss the patient’s podiatric pathology with the fellows. Provide instruction to approximately 6-8 fellows per year. Total instruction time: 4 hours/week or 256 hours/year.

1999 - Combined Orthopedic Residency Program, Lecture Series. I prepared and presented a lecture on podiatric sports injuries in the pediatric athlete to the orthopedic residents. This was part of their ongoing lecture series. Total instruction time: 6 hours/year.

Continuing Medical Education Courses: Local: 1986 - Beth Israel Deaconess Medical Center, Boston, Mass. Diabetic Foot Management Seminar This Harvard Medical School sponsored course is attended by approx. 300 internists, vascular surgeons, orthopedic surgeons, podiatrists and nurses. As a faculty member, I am responsible for preparing a course syllabus and presenting one lecture and participating on 2 discussion panels. Total time: 10 hours/year. 1987 - Joslin Diabetes Center, Boston, Mass. Diabetes for the Practicing Physician - Foot Management This annual course is organized by the Joslin Diabetes Center and sponsored by Harvard Medical School for the internist, endocrinologist and family practitioner. My role was as a faculty member discussing common diabetic foot problems and their management to approx. 50 physicians. Total time: 10 hours/year.

1995 - Joslin Diabetes Center, Boston, Mass. Diabetes Management Seminar - This semiannual course is organized by the Joslin Diabetes Center for diabetes nurse educators, registered nurses and visiting nurses. My role is as lecturer presenting diagnosis and management of diabetic foot problems. Total time: 6 hours/year. 1995 - Beth Israel Deaconess Medical Center, Boston, Mass. Visiting Physician Program - From time to time, physicians from around the country or from overseas will spend time in the clinic observing my evaluation and management of patients with complicated diabetic foot problems. This is followed by a brief discussion of the patient’s pathology and treatment plan. Total time: 15 hours/year.

1998 - Center for Wound Care Excellence Boston, Massachusetts “Practical Approaches to Diabetic Neuropathic Ulcerations”

Presented lecture & ran workshop at this University of Pittsburgh sponsored course for approx. 200 physicians and nurses. Total time:10 hours

Regional/National: 1990 Montana Podiatric Medical Society, Billings, Montana “Diabetic Foot Workshop” Presented a one-day symposium on diabetic related foot problems and their management to approx. 20 podiatrists. Total time: 8 hours. Univ. Calif./Calif. College Podiatric Medicine, San Francisco, Calif. Diabetic Foot and Ankle Seminar “Metatarsal Procedures for Diabetic Foot Ulcerations”

“Panmetatarsal Head Resections for Chronic Ulcerations” Presented lectures to approx. 150 podiatrists and participated on discussion panel. Total time: 8 hours.

1991 American Diabetes Association Scientific Seminar, Jacksonville, Florida “Relieving Abnormal Pressures in the Diabetic Foot” Presented lecture to approx. 100 internists, endocrinologists and diabetic nurse educators. Total time: 4 hours.

American Diabetes Association Scientific Seminar, El Paso, Texas “Relieving Abnormal Pressures in the Diabetic Foot’ Presented lecture to approx. 250 internists, endocrinologists and diabetic nurse educators. Total time: 4 hours. 1992 New Mexico Podiatric Medical Society, Santa Fe, New Mexico “Diabetic Foot Infections - A Podiatric Perspective” Moderated and assisted in the development of this 2 day CME course for approx. 75 podiatrists. Total time: 25 hours. 1993 Calif. College Podiatric Medicine, San Francisco, Calif. Graduation Weekend Seminar “Pedobarographic Analysis of Neuropathic Ulcerations using F-scan Technology” “Charcot Joint Disease” Presented lecture and assisted in the development of this one day course for approx. 40 podiatrists. Total time: 10 hours.

1993 Univ. Calif. San Francisco/Calif. College Pod. Medicine San Francisco, Calif. Diabetic Foot and Ankle Seminar “The Perfect Antibiotic - Does it exist?” “Charcot Joint Disease” Presented lectures to approx. 200 podiatrists. Total time: 20 hours. 1994 New Mexico Podiatric Medical Society, Santa Fe, New Mexico “Evaluation and Management of Diabetic Foot Ulcers” “Surgical Salvage of the Diabetic Foot” “Charcot Joint Disease” Moderated, lectured and assisted in the development of this 2 day CME course for approx. 75 podiatrists. Total time: 25 hours. Calif. College Podiatric Medicine Super Seminar, Las Vegas, Nevada “Diabetic Foot Workshop” “Charcot Joint Disease” Lectured and developed case presentations for the workshop attended by approx. 300 podiatrists. Total time: 20 hours. Methodist Hospital/J.C. Davis Wound Care Center San Antonio, Texas “Mechanical Stress in Plantar Neuropathic Ulcerations”

Presented lecture to approx. 120 internists, vascular surgeons, wound care specialists and physical therapists. Total time: 5 hours. Calif. College Pod. Medicine, San Francisco, Calif. “Culture & Biopsy Techniques in the Diabetic Foot” “What’s New in Wound Healing?” Presented lecture to approx. 120 podiatrists. Total time: 10 hours. 1994 Univ. Texas Health Science Center, San Antonio, Texas Diabetic Foot Seminar “Evaluation and Surgical Decision-making in the Diabetic Foot” “Evaluation and Management of Diabetic Foot Ulcers” Presented lecture to approx. 250 podiatrists, internists, vascular surgeons, diabetic nurse educators and wound care specialist at this 2 day course. Total time: 10 hours.

1995 Methodist Hospital/J.C. Davis Wound Care Center San Antonio, Texas “Mechanical Stress in Plantar Neuropathic Ulcerations” Presented lecture to approx. 120 internists, vascular surgeons, wound care specialists and physical therapists. Total time: 5 hours. 1998 Thomas R. Beam Jr. Memorial Institute for Continuing Med. Education San Francisco, California “Integrating New Approaches in the Treatment of Diabetic Foot Ulcers” Presented & moderated program for approx. 60 podiatrists and wound care specialists. Total time: 6 hours. Thomas R. Beam Jr. Memorial Institute for Continuing Med. Education Los Angeles, California “Integrating New Approaches in the Treatment of Diabetic Foot Ulcers: Presented & moderated program for approx. 200 podiatrists, vascular surgeons and wound care specialists. Total time: 6 hours. 1998 California College of Podiatric Medicine Super Seminar, Las Vegas, Nevada “Diagnosing Osteomyelitis: A Simplified Approach” “Salvaging the Neuropathic Forefoot” “Diabetic Foot Workshop’ Presented lectures & ran workshops for approx. 200 podiatrists, residents and podiatric medical students. Total time: 30 hours 2000 - American College of Foot & Ankle Surgeons Diabetic Foot Symposium 2000 “Risks for Ulceration in the Diabetic Foot” “Metatarsal Surgery for the Ulcerated Foot” “Subtotal Calcanectomy in the Diabetic Patient”

Presented lectures in this ACFAS sponsored course for approx. 150 podiatrists. Total time: 15 hours

Advisory and Supervisory Responsibilities:

1987 - Podiatry Residents’ Training; I am involved an a daily basis in the clinical training of podiatry residents. This includes making daily inpatient rounds, supervising outpatient care by resident staff and providing intraoperative supervision and instruction to podiatric residents. I am responsible for the training of 3 residents per year. As Chief of the Division, my supervisory and teaching responsibilities are concurrent throughout the day within my practice.

1987 - Surgical Interns/Residents’ Training; I am involved in the day to day

teaching of surgical interns and residents by way of weekly conferences and consultations on diabetic and vascular patients. As Chief of the Division, my supervisory and teaching responsibilities are concurrent throughout the day within my practice.

1987 - Medical Interns/Residents/Fellows Training; I interact with medical

interns, residents and fellows as it relates to the care of diabetic patients with foot problems and severe medical conditions. This takes the form of patient rounds, conferences or consultations. As Chief of the Division, my supervisory and teaching responsibilities are concurrent throughout the day within my practice.

1987 - Podiatry Students’ Training; I interact with podiatry students from the

nation’s podiatry schools and provide instruction to them in the way of daily walk rounds and patient care discussion, formal lectures and surgical instruction in the operating room. As Chief of the Division, my supervisory and teaching responsibilities are concurrent throughout the day within my practice.

Leadership Roles: 1987 - 1997 Director, Reseach & Fellowship Training; See under Graduate Education. 1996 - 2000 Director of Podiatric Medical Education; See under Graduate Education. 1996 - 2000 Graduate Medical Education Committee; As a member of this policy-making committee, I participate in internal residency reviews. I also participate in discussions on issues affecting all graduate and post-graduate teaching programs of the Beth Israel Deaconess Medical Center. 1997 - 2000 American Podiatric Medical Association Council on Podiatric Medical Association, Joint Residency Review Committee As a member of this national committee, I serve as an on-site evaluator of the nation’s podiatric residency programs assuring they meet national standards for all podiatric training programs.

1998 American Diabetes Association Scientific Abstracts Presentation, Annual Meeting, Chairperson

Chaired and moderated discussion of 8 abstract presentations at the annual meeting of the ADA. This was attended by physicians, podiatrists, nurses and researchers (nationally and internationally) who devote their time to the area of the diabetic foot.

2000 - 2003 American College of Foot & Ankle Surgeons Board of Directors

As an elected official, I contribute to the administration and decision making of the College. This includes policy making, development of educational programs for members and serving as the liasion to the Board on several committees for the College.

Regional Contributions: Invited Presentations: 1984 Univ. of Massachusetts Medical School, Worcester, Mass. Department of Orthopedics - Foot Rounds “Bone Tumors of the Lower Extremity” Total time: 10 hours 1989 Massachusetts Society of Radiologic Technologists, Boston, Massachusetts “Injuries of the Lower Extremity in Running” Total time: 10 hours 1990 Amer. Podiatric Medical Assoc., Region I Meeting, Boston, Massachusetts “Evaluation and Surgical Decision-making in the Diabetic Patient” Total time: 10 hours 1991 St. Michael’s Medical Center, Newark, New Jersey Grand Rounds - Section of Podiatry “Bone Tumors of the Lower Extremity” Total time: 5 hours 1993 Parkway Regional Hospital, Forest Hills, New York Grand Rounds - Section of Podiatry “Charcot Joint Disease Total time: 5 hours 1993 Sturdy Memorial Hospital, Attleboro, Massachusetts “A Systemized Approach to Foot Pain” Total time: 10 hours 1994 Nassau County Medical Center, Long Island, New York Grand Rounds - Section of Podiatry “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours

1995 Amer. Pod. Medical Assoc., Region Three, Atlantic City, New Jersey “Charcot Joint Disease” “Surgical Decision-making in the Diabetic Patient” Total time: 8 hours

Milford-Whitinsville Hospital, Milford, Massachusetts Medical & Surgical Grand Rounds “Evaluation and Treatment of Diabetic Foot Ulcers” Total time: 8 hours

1997 - Boston Marathon Sports Conference, Babson College, Wellesley, Massachusetts Governor’s Council on Physical Fitness “Orthoses & Footwear in the Distance Runner” Total time: 4 hours 1998 St. Luke’s Hospital, New Bedford, Massachusetts Surgical Grand Rounds “Surgical Decision Making in the Diabetic Patient” Total time: 4 hours

1998 Sturdy Memorial Hospital, Attleboro, Massachusetts Orthopedic Grand Rounds “Surgical Decision Making in the Diabetic Patient” Total time: 4 hours

1998 American College of Sports Medicine, New England Chapter, Providence, Rhode Island

Annual Meeting “Foot Injuries in the Pediatric Athlete” Total time: 8 hours

2000 Boston Marathon Sports Conference, Hynes Convention Center, Boston, Massachusetts Governor’s Council on Physical Fitness “Orthoses and Footwear in the Distance Runner” Total time: 4 hours 2000 Deaconess Waltham-Weston Hospital, Waltham, Massachusetts Surgical Grand Rounds “New Interactive Approaches for Diabetic Ulcerations” Total time: 4 hours

2001 New England Baptist Hospital Orthopedic Grand Rounds “Surgical Salvage of the Diabetic Foot” Total time: 6 hours

2002 Beth Israel Deaconess Medical Center Surgical Grand Rounds “Charcot Joint Disease: A Medical or Surgical Problem?” Total time: 10 hours

National Contributions: Invited Presentations:

1983 Waldo General Hospital, Seattle, Washington Department of Podiatry “Antibiotic Prophylaxis in Podiatric Surgery” Total time: 10 hours 1986 L.A. County/U.S.C. Medical Center, L.A. County/U.S.C. Medical Center Grand Rounds - Section of Podiatry “Operative Evaluation and Considerations in the Diabetic Patient” Total time: 10 hours L.A. County/U.S.C. Medical Center, Los Angeles, California “Neuroarthropathic Joint Disease in Diabetes” Total time: 10 hours

1988 Amer. Diabetes Assoc., Desert Springs, California

“Management of Neuropathic Ulcers” Total time: 5 hours

1990 Scholl College of Podiatric Medicine, Chicago, Illinois “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 10 hours

Calif. College of Podiatric Medicine, San Francisco, California Surgical Grand Rounds “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours Doxie Hatch Hospital, Salt Lake City, Utah Grand Rounds - Section of Podiatry “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours Community Hospital of Phoenix ,Phoenix, Arizona Grand Rounds - Section of Podiatry “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours 1991 San Diego Podiatric Medical Society, San Diego, California “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours

1991 Michigan Podiatric Medical Society, Grand Rapids, Michigan “Relieving Abnormal Pressures in the Diabetic Foot’ Total time: 8 hours 1992 Inland Empire Podiatric Medical Society, Ontario, California “Role of Pulsed Electromagnetic Fields in Podiatric Medicine” Total time: 5 hours 1992 University Texas Health Science Center, San Antonio, Texas Grand Rounds - Section of Podiatry

“Surgical Decision-making in the Diabetic Patient” Total time: 8 hours

1993 Dallas County Podiatric Medical Society, Dallas, Texas “Delayed and Non-unions: Diagnosis and Treatment “Charcot Joint Disease” Total time: 10 hours 1994 Kaiser Permanente Hospital, Industry Hills, California Grand Rounds - Section of Podiatry “Charcot Joint Disease” Total time: 5 hours 1995 Florida Pod. Medical Society, Orlando, Florida “Charcot Joint Disease” “Pathophysiology of Wound Repair” “Surgical Decision-making in the Diabetic Patient” Total time: 18 hours

1996 Youngstown Osteopathic Hospital, Youngstown, Ohio “Practical Approaches to the Neuropathic Ulcer” “Surgical Decision-making in the Diabetic Patient” Total time: 12 hours 1998 Pennsylvania College of Podiatric Medicine, Philadelphia, Pennsylvania “Surgical Decision-making in the Diabetic Patient: “Charcot Reconstruction; Plastic Procedures; Challenging Foot and Ankle Infections” Total time: 8 hours

1999 American Podiatric Medical Association, Region 7 International Seattle, Washington “Surgical Decision-making in the Diabetic Patient” “Diagnosis and Treatment of Charcot Joint Disease” Total time: 8 hours

Symposium on the Diabetic Foot College of Physicians & Surgeons San Jose, Costa Rica “Practical Approaches in the Treatment of the Neuropathic Ulceration” “Surgical Decision-making in the Diabetic Patient” Total time: 8 hours 2000 XV Congresso Nazionale di Podologia Associazione Italiana di Podologia Universita di Roma Perugia, Italy “Office Management of Diabetic Neuropathic Ulcerations” Total time: 4 hours Northwest Podiatric Foundation Seminar Providence Hospital

Seattle, Washington “Salvage of the 1st Ray in Patients with Diabetes” “PMHR vs. TMA: A Critical Look” “Rearfoot Procedures in the Diabetic Patient”

2001 New England Medical Center Surgical Grand Rounds “New Therapeutic Approaches to the Diabetic Foot Ulcer” Total time: 4 hours West Penn Hospital Pittsburgh, Pennsylvania Scott Alter Memorial Lectures “Preventive Foot Surgery in the Diabetic Patient” “Salvage of the Diabetic Forefoot” “Charcot Joint Disease” Total time: 12 hours Rhode Island Hospital/Brown Medical School Endocrinology Grand Rounds

“Evaluation and Management of Diabetic Foot Ulcers: Risk assessment, diagnostic interventions and management principles” Total time: 4 hours

Professional Leadership Roles: 1997 - 2000 American Podiatric Medical Association

Council on Podiatric Medical Education Joint Residency Review Committee: See under Leadership Roles 2000 - 2003 American College of Foot & Ankle Surgeons Board of Directors Bibliography: Original Articles: 1. Giurini JM, Habershaw GM, Chrzan JS. Panmetatarsal head resection in chronic

neuropathic ulceration. J. of Foot Surgery, 1987; 26:3, 247-52. 2. Tillo TH, Giurini JM, Habershaw GM, Chrzan JS, Rowbotham JL. Review of metatarsal

osteotomies for the treatment of neuropathic ulcerations. J.Amer.Pod. Med. Assoc., 1990; 80:4, 211-17.

3. Giurini JM, Habershaw GM, Chrzan JS, Gibbons GW. Sesamoidectomy for the treatment of

chronic neuropathic ulcerations. J.Amer.Pod.Med.Assoc., 1991; 81:4, 167-73. 4. Chrzan JS, Giurini JM, Hurchik JM. A biomechanical model for the transmetatarsal

amputation. J.Amer.Pod.Med.Assoc., 1993; 83:2, 82-6.

5. Barry DC, Sabacinski KA, Habershaw GM, Giurini JM, Chrzan JS. Tendoachilles procedures for chronic ulcerations in diabetic patients with transmetatarsal amputations. J.Amer.Pod.Med.Assoc., 1993; 83:2, 96-100.

6. Giurini JM, Basile P, Chrzan JS, Habershaw GM, Rosenblum BI. Panmetatarsal head

resection: a viable alternative to the transmetatarsal amputation. J.Amer.Pod.Med.Assoc., 1993; 83:2, 101-7.

7. Rosenblum BI, Pomposelli FB, Giurini JM, Gibbons GW, Freeman DV, Chrzan JS,

Campbell DR, Habershaw GM, LoGerfo FW. Maximizing foot salvage by a combined approach to foot ischemia and neuropathic ulceration in patients with diabetes: a 5-year experience. Diabetes Care. 1994; 17:9, 983-

8. Sarnow MR, Veves A, Giurini JM, Rosenblum BI, Chrzan JS, Habershaw GM. In-shoe foot

pressure measurements in diabetic patients with at-risk feet and in healthy subjects. Diabetes Care 1994; 17:9, 1002-6.

9. Rosenblum BI, Giurini JM, Chrzan JS, Habershaw GM. Preventing loss of the great toe with

the hallux interphalangeal joint arthroplasty. J. Foot & Ankle Surgery 1995; 33:6, 557 -60. 10. Veves A, Sarnow MR, Giurini JM, Rosenblum BI, Lyons TE, Chrzan JS, and Habershaw

GM: Differences in joint mobility and foot pressures between black and white diabetic patients. Diabetic Medicine. 1995; 12:7, 585-589.

11. Donaghue VM, Giurini JM, Rosenblum BI, Weissman PN, Veves A. Variability in function

measurements of three sensory foot nerves in neuropathic diabetic patients. Diabetes Research and Clinical Practice. 1995; 29, 37-42.

12. Veves A, Donaghue VM, Giurini JM, Mullooly CA, Kistler JA and Fielding RA. Peripheral

and autonomic nerve function and risk factors for foot problems in diabetic athletes. Diabetes Suppl 1:A52 1995; 44.

13. Donaghue VM, Sarnow MR, Giurini JM, Chrzan JS, Habershaw GM and Veves A.

Longitudinal in-shoe foot pressure relief achieved by specially designed footwear in high risk diabetic patients. Diabetes Research and Clinical Practrice 1996; 31, 109-114.

14. Donaghue VM, Fielding RA, Giurini JM, Mullooly CA, Kistler JA, Horton ES and Veves

A. The effect of diabetes and neuropathy in the exercising capacity of athletically trained subjects. Diabetologia Suppl 1:A52 1995; 38.

15. Veves A, Saouaf R, Donaghue VM, Mullooly CA, Kistler JA, Giurini JM, Horton ES,

Fielding RA. Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients. Diabetes 1997: 46:1846-1852.

16. Rosenblum BI, Giurini JM, Miller LB, Chrzan JS, Habershaw GM. Neuropathic ulcerations

plantar to the lateral column in patients with Charcot foot deformity: A flexible approach to limb salvage. J. Foot & Ankle Surg. 1997 36:5, 360-363.

17. Veves A, Donaghue VM, Sarnow MR, Giurini JM, Campbell DR and LoGerfo FW. The

impact of reversal of hypoxia by revascularization in the peripheral nerve function in diabetic patients. Diabetologia. 1996 39:344-348.

18. Donaghue VM, Chrzan JS, Rosenblum BI, Giurini JM, Habershaw GM, Veves A. A clinical

evaluation of a collagen-alginate topical wound dressing (FIBRACOLR Dressing) in the management of diabetic foot ulcers. Advances in Wound Care. 1998 11:114-117.

19. Pham HT, Rosenblum BI, Lyons TE, Giurini JM, Chrzan JS, Habershaw GM, Veves A.

Treatment with a human skin equivalent, Graftskin (ApligraftR), improves healing rate in diabetic foot ulcers. Diabetologia. 1999

20. Veves A, Pham HT, Rosenblum BI, Lyons TE, Giurini JM, Chrzan JS, Habershaw GM.

Evaluationof Graftskin (ApligrafR), a human skin equivalent for the treatment of diabetic foot ulcers in a prospective, randomized clinical trial. Wounds:A Compendium of Clinical Research and Practice. 1999

21. Pham HT, Armstrong DG, Harvey C, Harkless LB, Giurini JM, Veves A. Screening

techniques to identify the at-risk patients for developing diabetic foot ulcers in a prospective multicenter trial. Diabetes Care. 2000, 23:1-6.

Reviews,Chapters, Editorials: 1. Giurini JM. The evaluation and management of ischemic foot ulcers in the diabetic patient.

J. Current Podiatric Medicine, 1989; 38:5, 9-11. 2. Giurini JM, Chrzan JS, Habershaw GM, Gibbons GW. Charcot's disease in diabetic patients.

Postgraduate Medicine,1991; 89:4, 163-169. 3. Giurini JM. Healing fractures with pulsed electromagnetic fields. The Contemporary

Podiatric Physician,1991; 8:5, 41-45. 4. Giurini JM. Applications and use of in-shoe orthoses in the conservative management of

Charcot foot deformity. Clinics in Podiatric Med. and Surgery. 1994; 11:2, 271-8. 5. Giurini JM, Rosenblum BI. The role of foot surgery in patients with diabetes. Clinics in

Podiatric Med. and Surgery. 1995; 12:1, 119 -27. 6. Giurini JM. Chapter 9: Diabetes. In: Kominsky S, ed. Compendium of Podiatric Medicine

and Surgery 2000. 2000:125-146. 7. Giurini JM. Chapter 9: The Diabetic Foot/Wound Care. In: Kominsky S, ed. Compendium

of Podiatric Medicine and Surgery 2001. 2001:143 – 162. Books: 1. Frykberg RF, Giurini JM, Habershaw GM, Chrzan JS, Rosenblum BI. Prophylactic surgery

in the diabetic patient. In: Kominsky S, ed. Medical and Surgical Management of the Diabetic Foot. Philadelphia: C.V. Mosby, 1994: 399 - 439.

2. Kozak GP, Giurini JM. Diabetic Neuropathies of the lower extremity. In: Kozak GP,

Campbell DR, Frykberg RF, Habershaw GM., eds. Management Of Diabetic Foot Problems, 2nd edition. Orlando: W.B. Saunders, 1994: 43 - 52.

3. Habershaw GM, Chrzan JS, Giurini JM. Reconstructive foot surgery for the diabetic patient. In: Kozak GP, Campbell DR, Frykberg RF, Habershaw GM. eds. Management Of Diabetic Foot Problems, 2nd edition. Orlando: W.B. Saunders, 1994: 213 - 225.

4. Giurini JM, Rosenblum BI, Lyons TE. Management of the Diabetic Foot. In: Veves A. The

Clinical Management of Diabetic Neuropathy. Totowa, NJ: Humana Press, 1998: 303-318 5. Giurini JM, Rosenblum BI. Surgical Treatment of the Diabetic Foot. In: McGlamry

E.D.Comprehensive Textbook on Foot Surgery, 3rd Edition. Philadelphia, Pa. Lippincott Williams & Wilkins, 2001: 1595 – 1616.

6. Giurini JM. Evaluation and Management of the Diabetic Foot. In: Joslin, Diabetes Mellitus,

14th Edition. In Press. 7. Giurini JM. Surgical Managment of Diabetic Foot Problems. In: Veves, Giurini, LoGerfo.

Management of the Diabetic Foot. In Press. 8. Veves A, Giurini JM, LoGerfo FW. Editor: Management of the Diabetic Foot. Totowa,

NJ.,Humana Press, In Press Clinical Communications: 1. Frykberg RG, Armstrong DA, Giurini JM, Edwards A, Kravette M, Kravitz S, Ross C,

Stavosky J, Stuck R, Vanore J. Diabetic Foot Disorders: A Clinical Practice Guideline. Supplement to J. Foot & Ankle Surg. 2000. S39:1-60.

2. Sabacinski KA, Tillo TH, Giurini JM, Madras PM, Miller LB. Necrotizing fasciitis. J. of

Foot Surgery, 1989; 28:2, 106-11. 3. Giurini JM, Hopkins WE, Redner T, Santopietro F. Succinylcholine sensitivity and plasma

cholinesterase deficiency. J. of Foot Surgery, 1986; 25:5, 382-5. Educational Materials: 1. Diabetic Foot Management Course Syllabus, Harvard Medical School, 1987 – 2000. Non-Print Materials - Audiovisuals: 1. “A Stitch in Time – The Diabetic Foot” (videocassette). Wyeth-Ayerst, 2000. 2. “Conservative Management of the Diabetic Foot Deformities” (videocassette). Health

Science & Technology Network, November, 2000. 3. “Surgical Management of the Diabetic Foot” (videocassette). Health Science & Technology

Network, December, 2000. Abstracts: 1. Sabacinski KA, Habershaw GM, Chrzan JS, Giurini JM. Achilles tenectomy for the salvage

of the TMA. Presented at the Annual meeting of the APMA. Boston, Mass. August 1989.

2. Rosenblum BI, Giurini JM, Habershaw GM, Chrzan JS. The surgical treatment of chronic neuropathic ulcerations of the first ray in patients with diabetes mellitus. Presented at the Annual meeting of the APMA. Las Vegas, Nevada. August 1990.

3. Kozak K, Ladin Z, Giurini JM. Biomechanical assessment of orthoses prescribed for

excessive pronation. Presented at IEEE Engineering in Medicine and Biology Conference. Philadelphia, Pa., 1991.

4. Giurini JM, Barry DC, Lawrence M, Chrzan JS, Habershaw GM, Rosenblum BI.

Pedobarographic analysis of neuropathic foot ulcerations using F-scan technology. Presented at the 50th Annual meeting of the American College Foot and Ankle Surgeons. Orlando, Fl. February 1992.

5. Giurini JM, Barry DC, Chrzan JS, Rosenblum BI, Lawrence M, Habershaw GM. A

preliminary analysis of the felted foam dressing for the management of diabetic foot ulcerations using F-scan technology. Presented at EMED users meeting. Flagstaff, Arizona, 1992.

6. Basile P, Chrzan JS, Giurini JM, Rosenblum BI, Habershaw GM. Evaluation of arthrodesis

and planing procedures for the treatment of neuropathic ulcerations related to medial column Charcot arthropathy. Presented at the 51st Annual meeting of the American College Foot and Ankle Surgeons. San Diego, Calif. February 1993.

7. Giurini JM, Chrzan JS, Habershaw GM, Rosenblum BI. Enhanced healing of severe

Charcot joint disease utilizing electrical bone stimulation. Presented at the 51st Annual meeting of the American College Foot and Ankle Surgeons. San Diego, Calif. February 1993.

8. Habershaw GM, Hurchik JM, Chrzan JS, Giurini JM, Rosenblum BI. Successful limb

salvage in diabetic patients with renal disease. Presented at the 51st Annual meeting of the American College Foot and Ankle Surgeons. San Diego, Calif. February 1993.

9. Giurini JM, Habershaw GM, Chrzan JS, Rosenblum BI, Basile P. Reduction of primary

lower extremity amputations in the diabetic patient utilizing a multidisciplinary approach. Presented at the 51st Annual meeting of the American College Foot and Ankle Surgeons. San Diego, Calif. February 1993.

10. Giurini JM, Rosenblum BI, Basile P, Miller LB, Chrzan JS, Habershaw GM.

Fasciocutaneous pedicle flaps for the treatment of plantar ulcerations resulting from Charcot arthropathy. Presented at the 52nd Annual meeting of the American College of Foot and Ankle Surgeons. Miami Beach, Fl. February 1994.

11. Rosenblum BI, Giurini JM, Basile P, Chrzan JS, Habershaw GM. Forefoot salvage with

panmetatarsal head resection in patients with prior ray resections. Presented at the 52nd Annual meeting of the American College of Foot Surgeons. Miami Beach, Fl. February 1994.

12. Rosenblum BI, Giurini JM, Basile P, Chrzan JS, Habershaw GM, Complications following

partial calcanectomy. Presented at the 52nd Annual meeting of the American College of Foot and Ankle Surgeons. Miami Beach, Fl. February 1994.

13. Veves A, Donaghue VM, Sarnow MR, Giurini JM, Campbell DR and LoGerfo FW.

Reversal of hypoxia by revascularization in diabetic patients: Any effect in the peripheral

nerve function? Proceedings of the European Association for the Study of Diabetes National Meeting, Stockholm, Sweden, 1995.

14. Pham HT, Veves A, Habershaw GM, Chrzan JS, Giurini JM, Rosenblum BI. A prospective

non-comparative evlauation of a new range of low-adherent products in chronic diabetic ulcers. 13th Annual Clinical Symposium on Wound Care, Atlanta, Georgia, 1998.

15. Pham HT, Mendeszoon E, Oglesby K, Chrzan JS, Giurini JM, Rosenblum BI, Habershaw

GM. Review of Charcot Joint. 57th American College of Foot and Ankle Surgeons Annual Meeting and Scientific Seminar, Los Angeles, Calif., 1999.

UNIVERSITY OF MIAMI

Curriculum Vitae

Date: January 6, 2005 I. PERSONAL Name: Robert S. Kirsner, M.D., PhD Phone Home: (305) 856-6139 Phone Office: (305) 575-3167 Address (home): 46 Samana Drive Miami, Florida 33133 Status: Full-Time Current Rank: Associate Professor of Clinical Dermatology Primary Department: Department of Dermatology and Cutaneous Surgery Citizenship: United States Visa Type: "Not applicable" II. HIGHER EDUCATION 1980 - 1981 SOUTHERN ILLINOIS UNIVERSITY Carbondale, Illinois 1981 - 1984 TEXAS A & M UNIVERSITY College Station, Texas Bachelor of Arts in Chemistry 1984 - 1988 UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Miami, Florida Doctor of Medicine 1996 - 2004 UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

Department of Epidemiology / Public Health Doctor of Philosophy

POST DOCTORAL TRAINING a. Internship 07/88 - 06/89 UNIVERSITY OF MIAMI/JACKSON MEMORIAL HOSPITAL

Department of Internal Medicine Miami, Florida Intern

b. Residency 07/89 - 06/90 UNIVERSITY OF MIAMI/JACKSON MEMORIAL HOSPITAL Department of Internal Medicine Miami, Florida Resident 07/92 - 06/94 UNIVERSITY OF MIAMI/JACKSON MEMORIAL HOSPITAL Department of Dermatology Miami, Florida

Resident 07/94 - 06/95 UNIVERSITY OF MIAMI/JACKSON MEMORIAL HOSPITAL Department of Dermatology Miami, Florida Chief Resident c. Fellowship: UNIVERSITY OF MIAMI/JACKSON MEMORIAL 07/90 - 06/92 HOSPITAL Department of Dermatology Miami, Florida Fellow in Wound Healing BOARD CERTIFICATION AND LICENSURES 03/89 Diplomate, National Board of Medical Examiners. 03/90 Florida Medical License #ME-0058219. 10/95 Diplomate, American Board of Dermatology. 05/97 Diplomate, American Academy of Wound Management

II. PROFESSIONAL EXPERIENCE III. Academic 01/95 - 06/95 Instructor UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Department of Dermatology Miami, Florida 02/95 - 09/98 Consultant Dermatologist GERIATRIC CENTER Cedars Medical Center Miami, Florida 07/95 – 6/01 Assistant Professor of Dermatology UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Department of Dermatology Miami, Florida 6/01 – Present Associate Professor of Dermatology UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Department of Dermatology Miami, Florida 07/95 – 8/02 Associate Chief of Inpatient Services CEDARS MEDICAL CENTER Department of Dermatology Miami, Florida 07/95 - Present Attending Physician

JACKSON MEMORIAL MEDICAL CENTER Department of Dermatology Miami, Florida 08/95 - Present Attending Physician VETERANS ADMINISTRATION MEDICAL CENTER Department of Dermatology Miami, Florida 02/97 - 6/98 Co-Director - Wound C.U.R.E. Center CEDARS MEDICAL CENTER Miami, Florida 06/98 - Present Director - Wound C.U.R.E. Center CEDARS MEDICAL CENTER Miami, Florida

07/02 – 9/04 Chief of Dermatology VETERANS ADMINISTRATION MEDICAL CENTER Department of Dermatology Miami, Florida HOSPITAL AFFILIATIONS 02/95 - Present CEDARS MEDICAL CENTER Miami, Florida 03/95 - Present KINDRED/VENCOR/THC HOSPITAL Hollywood, Florida 07/95 - Present JACKSON MEMORIAL MEDICAL CENTER Miami, Florida 08/95 - Present VETERANS ADMINISTRATION MEDICAL CENTER Miami, Florida 01/96 - Present SYLVESTER COMPREHENSIVE CANCER CENTER

Miami, Florida IV. PUBLICATIONS BOOKS AND BOOK CHAPTERS

1) Kirsner RS, Falanga V: The technique of skin grafting. J Dermatol Surg Oncol 1993; 19: 779-783. 2) Kirsner RS, Eaglstein WH: The wound healing process. Dermatology Clinics 1993; 11: 629-640. 3) Kirsner RS, Kerdel FA: Sarcoidosis. In: Cutaneous Medicine and Surgery. Arndt KA,

Leboit PE, Robinson JK, Wintroub BU. W.B. Saunders, Philadelphia, 1995. 4) Berman B, Kirsner RS. The Miami Review for the Certifying examination of the

American Board of Dermatology. Mosby-Wolfe Publisher, London, 1996.

5) Berman B, Kirsner RS, Machler BC. The 1997 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 1997. 6) Berman B, Kirsner RS, Machler BC. The 1998 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 1998

7) Kirsner RS: Metrotrexate Protocol and Patient Satisfaction. American Academy of Dermatology: Quality of Care Manuel. American Academy of Dermatology, Evanston, IL 1999 8) Kirsner RS: Venous Ulcers. Conn’s Current Therapy.

W.B. Saunders Publisher, New York, 1999 9) Berman B, Kirsner RS, Machler BC. The 1999 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 1999 10) Federman DG, Kirsner RS: The primary care physician and the dermatologist in the treatment of patients with skin disease.

Dermatology Clinics 2000;18:215-221. 11) Kerdel FA, Kirsner RS: Inpatient Dermatology. Dermatology Clinics

Mosby-Wolfe Publisher, St. Louis 2000 12) Berman B, Kirsner RS, Machler BC. The 2000 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 2000 13) Kirsner RS, Hannon W, Agarwal A, Kerdel FA: The effect of health care delivery systems on admission to and treatment at an inpatient dermatology unit. Dermatology Clinics 2000;18:391-395. 14) Prodanovich S, Kirsner RS, Taylor JR: Treatment of patients hospitalized with psoriasis. Dermatology Clinics 2000;18:425-435. 15) Yang D, Kerdel FA, Kirsner RS: Inpatient Dermatology: The difficulties, the reality, and

the future. Dermatology Clinics 2000;18:383-390. 16) Prodanovich S, Kirsner RS, Kerdel FA: Inpatient Dermatology: A prescription for survival. Dermatology Clinics 2001;19:593-602.

17) Berman B, Kirsner RS, Machler BC. The 2001 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 2001 18) Kirsner RS, Bogensberger G: The Wound Healing Process. In: Wound Healing Alternatives in Management. 3rd Edition. McColluch JM, Kloth LC, Feedar JA.

F.A. Davis Company, Philadelphia, 2001 19) Bello YM, Falabella AF, Kirsner RS. Tissue Engineered Skin. In: Tissue Engineering

and Biodegradable Equivalents: Scientific and Clinical Applications edited by Kai-Uwe Lewandroski, Donald L. Wise, Debra J. Trantolo, Joseph D. Gresser, Michael J. Yaszemski & David E. Altobelli.

Marcel Dekker Inc. New York, NY. 20) Berman B, Kirsner RS, Machler BC. The 2002 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 2002 21) Kirsner RS: Venous Ulcers. Conn’s Current Therapy.

W.B. Saunders Publisher, New York, 2003

22) Berman B, Kirsner RS, Machler BC. The 2002 Miami Review for the Certifying examination of the American Board of Dermatology.

Mosby-Wolfe Publisher, London, 2003 23) Drosou A, Kirsner RS: Keratinizing Disorders. In: Dematology- Just The Facts. Eds:

Kerdel FA, Jimenez-Acosta F McGraw-Hill, New York, 2003

24) Trent J, Kirsner RS: Skin Grafting. In: Techniques in Dermatologic Surgery. Eds: Nouri

K, Leal-Khouri S. Mosby, Edinburgh, 2003 25) Kirsner RS: Wound Healing. In: Dermatology. Eds: Bolognia JL, Jorizzo JL, Rapini RP. Mosby, New York, 2003 26) de Araju T, Kirsner RS: Atypical wounds. In Wound Care Essentials. Eds Baranoski S,

Ayello EA. Lippincott Williams & Wilkins, 2004 JURIED OR REFEREED JOURNAL ARTICLES 1) Weiss DS, Kirsner RS, Eaglstein WH: Electrical stimulation and wound healing.

Arch Dermatol 1990; 126: 222-225. 2) Falanga V, Kirsner RS, Katz MH, Eaglstein WH, Kerdel FA: Stanozolol in the treatment

of leg ulcers due to cryofibrinogenemia. Lancet 1991; 338: 347-348. 3) Katz MH, Alvarez AF, Kirsner RS, Eaglstein WH, Falanga V: Human wound fluid from

acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol 1991; 25: 1054-1058. 4) Bieley HC, Kirsner RS, Reyes BA, Garland LD: Determination of residual tumor in

incompletely excised basal cell carcinomas utilizing Mohs micrographic surgery. J Am Acad Dermatol 1992; 26: 754-756. 5) Falanga V, Kirsner RS, Katz MH, Gould E, Eaglstein WH, McFalls S: Pericapillary

fibrin cuffs in venous ulceration: Persistence with treatment and during ulcer healing. J Dermatol Surg Oncol 1992; 18: 409-414. 6) Kirsner RS, Falanga V: Features of an autoimmune process in mid-dermal elastolysis. J Am Acad Dermatol 1992; 27: 832-834. 7) Kirsner RS, Pardes JB, Falanga V: L-tryptophan associated progressive systemic

sclerosis. Eur J Derm 1992; 2: 549-551. 8) Falanga V, Katz MH, Kirsner RS, Alvarez, AF: The effects of Endothelin-1 on human

dermal fibroblast growth and synthetic activity. J Surg Res 1992; 53: 515-519. 9) Kirsner RS, Eaglstein WH, Katz MH, Kerdel FA, Falanga V: Stanozolol causes rapid

pain relief and healing of cutaneous ulcers due to cryofibrinogenemia. J Am Acad Dermatol 1993; 28: 71-74. 10) Kirsner RS, Pardes JB, Falanga V: Solitary fibrosing paraspinal plaque: Solitary

morphea profunda? Br J Dermatol 1993; 128: 99-101. 11) Kirsner RS, Pardes JB, Eaglstein WH, Falanga V: The clinical spectrum of

lipodermatosclerosis. J Am Acad Dermatol 1993; 28: 623-627. 12) Kirsner RS, Haiken M, Garland LD: Margin assessment of selected basal cell

carcinomas utilizing laser doppler velocimetry. Int J Dermatol 1993; 32: 390-292.

13) Kirsner RS, Goodless D, Kerdel FA, Pardes JB, Falanga V: Enlargement of hands and feet in a chronic smoker.

Arthritis Rheum 1993; 36: 569-571. 14) Kirsner RS, Falanga V, Eaglstein WH: The biology of skin grafts: Skin grafts as

pharmacologic agents. Arch Dermatol 1993; 129: 481-483. 15) Kirsner RS, Katz MH, Eaglstein WH, Falanga V: The biology of wound fluid. Wounds 1993; 5: 122-128. 16) Falanga V, Kirsner RS: Low oxygen stimulates proliferation of fibroblasts seeded as

single cells. J Cell Physiol 1993; 154: 506-510. 17) Lima-Maribona J, Kirsner RS, Kerdel FA: Leg ulcer due to sickle cell anemia. J Am Acad Dermatol 1993; 29: 802-807. 18) Falanga V, Martin TA, Takagi H, Kirsner RS, Helfman T, Pardes JB, Ochoa M: Low

oxygen tension increased mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts.

J Cell Physiol 1993; 157: 408-412. 19) Kirsner RS, Garland LG: Squamous cell carcinoma arising from chronic osteomyelitis

treated by Mohs micrographic surgery. J Dermatol Surg Oncol 1994; 20: 141-143. 20) Asuncion AMV, Federman DG, Kirsner RS: Swelling of the ear in a patient with

ulcerative colitis. Arthritis Rheum 1994; 37: 432-434. 21) Federman D, Valdivia M, Kirsner RS: Secondary syphilis presenting as the "Blue Toe

Syndrome". Arch Int Med 1994; 154: 1029-1031. 22) Falanga V, Brown H, Pardes JB, Kirsner RS: Leg ulceration due to the antiphospholipid

syndrome: Successful treatment with intralesional corticosteroids and failure of prolonged Stanozolol treatment.

J Eur Acad Derm Vener 1994; 3: 174-177. 23) Resnik BA, Kirsner RS, Kerdel FA: Self-Assessment examination of the American

Academy of Dermatology: Pemphigus Vegetans. J Am Acad Dermatol 1994; 31: 819-824. 24) Kirsner RS, Eaglstein WH, Falanga V: Treatment of lipodermatosclerosis (Letter Reply).

J Am Acad Dermatol 1994; 31: 133. 25) Kirsner RS, Anhalt GJ, Kerdel FA: Treatment with alpha-interferon associated with the

development of Paraneoplastic Pemphigus. Br J Derm 1995; 132: 474-478. 26) Federman DG, Hogan D, Taylor JR, Caralis PG, Kirsner RS: A comparison of diagnosis,

evaluation and treatment of patients with dermatologic disorders. J Am Acad Dermatol 1995; 32: 726-729. 27) Kirsner RS, Federman D: Treatment of psoriasis with calcipotriene (calcipotriol). Am Fam Physician 1995; 52: 237-240. 28) Kirsner RS, Mata SM, Falanga V, Kerdel FA: Split-thickness skin grafting of leg ulcers.

The University of Miami Dermatology's Experience (1990-1993). Dermatol Surg 1995; 21: 701-703. 29) Kirsner RS, Federman DG: Managed care: The dermatologist as a primary care provider.

J Am Acad Dermatol 1995; 33: 535-537. 30) Kirsner RS, Kerdel FA, Falanga V, Katz MH, Eaglstein: Skin Grafts As Pharmacologic Agents: Pre-Wounding of the Donor Site. Br J Dermatol 1996;135:292-296.

31) Kirsner RS, Federman DG: Lack Of Correlation Between Internists’ Ability in Dermatology And Their Patterns Of Treating Patients With Skin Disease. Arch Dermatol 1996;132:1043-1046. 32) Kirsner RS, Badiavas E: Terapeutica Genica.

Act Terap Dermatol 1996;19:37-40

33) Kirsner RS, Federman DG: The epidemiology of Non-Hodgkins Lymphoma. Connecticut Medicine 1996;60:579-582.

34) Kirsner RS, Spencer J, Falanga V, Garland LD, Kerdel FA: Squamous cell carcinoma arising in osteomyelitis and chronic wounds: Treatment with Mohs micrographic surgery vs. amputation.

Dermatol Surg 1996;22:1015-1018

35) Friedman P, Golomb C, Kirsner RS: Self-assessment examination for the American Academy of Dermatology. Angiosarcoma.

J Am Acad Dermatol 1997;36:147-148. 36) Kirsner RS, Freedberg IM, Kerdel FA: Inpatient Dermatology: Should we let it die or should we work toward regional centers?

J Am Acad Dermatol 1997;36:276-278. 37) Kirsner RS, Eaglstein WH, Kerdel FA: Split-thickness skin grafting for lower extremity ulcerations.

Dermatol Surg 1997;23:85-91. 38) Federman DG, Kirsner RS, Liang-Federman GS: Pica: Are you hungry for the facts.

Connecticut Medicine 1997;61:207-209. 39) Federman DG, Kirsner RS, Braverman I: A patient with Cutaneous T Cell Lymphoma and Dermatomyositis.

Cutis 1997;59:277. 40) Kirsner RS, Federman DG: Ausencia de correlacion entre la preparacion de los

internistas en dermatologica y sus patrones de tratamiento de los pacientes con enferedadas cutaneas.

Arch Dermatol Edicion Espanola 1997;8:12-16.

41) Kirsner RS, Federman DG: Cutaneous clues for systemic disease: Telltale skin signs enable early diagnosis.

Postgraduate Med 1997;101:137-150. 42) Hurwitz D, Kerdel FA, Kirsner RS: Hospitalization for skin disease improves quality of life.

Arch Dermatol 1997;133:797-798. 43) Colsky AS, Jegasothy SM, Kirsner RS, Kerdel FA: An unusual presentation of

scabies infestation in a patient with Darier’s disease. The use of ivermectin as an adjunctive scabicide.

J Dermatol Treat 1997;8:137-138.

44) Bellman B, Berman B, Sasken H, Kirsner RS: Cutaneous disseminated Histoplasmosis in AIDS patients in South Florida.

Int J Dermatol 1997;36:599-603.

45) Kerdel FA, Flores J, Kirsner RS, Falanga V: Pulse corticosteroid therapy for cutaneous diseases: efficacy and side effects.

J Dermatol Treat 1997;8:153-159.

46) Golomb CA, Jegasothy M, Kirsner RS: Self-assessment examination for the American Academy of Dermatology. Paraneoplastic Pemphigus.

J Am Acad Dermatol 1997;37:519-520.

47) Muhart M, McFalls S, Kirsner R, Kerdel F, Eaglstein WH: Bioengineered skin. Lancet 1997;350:1142.

48) Federman DG, Kirsner RS: The abilities of primary care physicians in dermatology: Implications for quality of care.

Amer J Managed Care 1997;3:1487-1492 49) Kirsner RS, Federman DG: Quality of care: The patient’s perspective.

Arch Dermatol 1997;133:1427-1431. 50) Federman DG, Concato J, Caralis PV, Hunkele GE, Kirsner RS: Screening for skin cancer in primary care settings.

Arch Dermatol 1997;133:1423-1425.

51) Kirsner RS, Eaglstein WH, Kerdel F: Injerto dermo-epidermico (“split thickness”) para las ulceras de las extremidades inferiores.

Act Terap Dermatol 1997:20:381-388

52) Kirsner RS, Federman DG: Video Display Terminals: The effect of Electromagnetic radiation.

South Med J 1998;91:12-16. 53) Colsky AS, Kirsner RS, Kerdel FA: Microbiological evaluation of cutaneous wounds in hospitalized dermatology patients.

Ostomy/Wound Management 1998;44:40-46. 54) Kirsner RS, Froelich CW: Soaps and Detergents: Understanding their composition and effect.

Ostomy/Wound Management 1998;44:62S-70S. 55) Colsky AS, Jegasothy SM, Leonardi C, Kirsner RS, Kerdel FA: Diagnosis and treatment of a case of cutaneous cytomegalovirus infection with a dramatic clinical presentation.

J Amer Acad Dermatol 1998;38:349-351. 56) Chang A, Spencer JM, Kirsner RS: Squamous cell carcinoma arising in a nonhealing wound and osteomyelitis treated with Mohs micrographic surgery: A case study.

Ostomy/Wound Management 1998;44:26-30. 57) Machler BC, Kirsner RS, Elgart GW: Routine histology for the diagnosis of

onychomycosis: Evaluation of sensitivity and specificity. Cutis 1998;61:217-219.

58) Kirsner RS, Falanga V, Eaglstein WH: The development of bioengineered skin.

Trends in Biotechnology 1998;16:246-249.

59) Federman DG, Trent JT, Froelich CW, Demirovic J, Kirsner RS: Epidemiology of peripheral vascular disease: a predictor of systemic vascular disease.

Ostomy/Wound Management 1998;44:58-69. 60) Lehrer-Bell K, Kirsner RS, Tallman PG, Kerdel FA: Treatment of the cutaneous

involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Silver Nitrate impregnated Soft-Sorb dressings.

Arch Dermatol 1998;134:877-879.

61) Colsky AS, Kirsner RS, Kerdel FA: Microbiologic evaluation of skin wound infections in hospitalized dermatology patients: The crisis of antibiotic resistance has come to the surface.

Arch Dermatol 1998;134:1006-1009. 62) Trent JT, Kirsner RS: Apligraf: A bi-layered living skin equivalent.

Int J Clin Pract 1998;52:408-413. 63) Kirsner RS, Federman DG: The rationale for skin cancer screening and prevention. Amer J Managed Care 1998;4:1279-1284. 64) Kirsner RS: The use of Apligraf for acute wounds.

J Derm 1998;25:805-811. 65) Kirsner RS, Federman DG: The ethical dilemma of population based medical decision making.

Amer J Managed Care 1998;4:1571-1576. 66) Kirsner RS, Kerdel FA, Liang-Federman G, Federman DG: Life-threatening skin infections.

Resident & Staff Physician 1998;44:15-22. 67) Bogensberger G, Elgart GW, Froelich CW, Kirsner RS: Lipodermatosclerosis.

Wounds 1999;11 Supplement A:2A-6A. 68) Federman DG, Froelich CW, Kirsner RS: Topical therapy for psoriasis.

Amer Fam Physician 1999;59:957-964. 69) Kirsner RS, Kerdel FA, Falanga V, Trent JT, Eaglstein WH: Dermatology education: The role of mandated research.

J Invest Dermatol 1999;112:400-401. 70) Federman DG, Kirsner RS: Leukocytoclastic vasculitis, Hepatitis B, and the risk of endoscopy.

Cutis 1999;63:86-87. 71) Federman DG, Concato J, Kirsner RS: Comparison of dermatologic diagnoses by

primary care practitioners and dermatologists: A review of the literature.

Arch Fam Med 1999;8:170-172. 72) Kirsner RS, Yang DG, Kerdel FA: The changing status of inpatient dermatology at American academic dermatology programs.

J Amer Acad Dermatol 1999;40:755-757.

73) Valencia IC, Chang A, Kirsner RS, Kerdel FA: Eosinophilic fasciitis responsive to treatment with pulsed steroids and cyclosporine.

Int J Dermatol 1999;38:369-372. 74) Rendon-Pellerano MI, Jerome L, Eaglstein WH, Kirsner RS, Hanft K, Pardo RJ: Laser resurfacing: Usual and unusual complications.

Dermatol Surg 1999;25:360-366. 75) Baumann LS, Kerdel FA, Agrawal A, Kirsner RS: A south Florida survey on the relationship between Academic Medical Centers and community physicians.

South Med J 1999;92:673-676.

76) Muhart M, McFalls S, Kirsner RS, Elgart G, Kerdel F, Sabolinski ML, Hardin- Young J, Eaglstein WH: Behavior of Tissue-Engineered Skin: A comparison of a living skin equivalent (LSE), autograft, and an occlusive dressing on human donor sites.

Arch Dermatol 1999;135:913-918.

77) Kirsner RS, Yang D, Kerdel FA: Dermatologic disease accounts for a large number of hospital admissions annually.

J Amer Acad Dermatol 1999;41:970-97. 78) Kirsner RS, Muhkerjee S, Federman DG: Skin cancer screening in primary care: Prevalence and barriers.

J Amer Acad Dermatol 1999;41:564-566. 79) Weiss E, Golomb C, Colsky A, Kirsner RS: Leukonychia totalis.

J Clin Dermatol 1999;2:14. 80) Weiss E, Brahmatewari J, Kirsner RS, Kerdel FA: Calciphylaxis in a patient with end- stage renal disease.

J Clin Dermatol 1999;2:17-18. 81) Kirsner RS, Federman DG: The changing face of dermatology: More than a cosmetic

one. Dermatopath Pract Concept 1999;5:371-373.

82) Kirsner R, Falanga V, Fivenson D, Thibodeaux K, Cavorsi J, de la Pava D, Brem H, Golomb CA: Clinical experience with a human skin equivalent for the treatment of venous leg ulcers: Process and outcomes.

Wounds 1999;11:137-144. 83) Federman DG, Kirsner RS: Acne Vulgaris: Pathogenesis and therapeutic approach.

Am J Managed Care 2000;6:78-89. 84) Federman DG, Kirsner RS: Fever and a rash in a sixty-one year old man.

Postgraduate Med 2000;76:237-244.

85) Sanchez J, Kirsner R, Cohen J, Kerdel FA: Treatment of Cutaneous T Cell Lymphoma with the combination of Extracorporeal Photochemotherapy and conventional Psoralen- Ultraviolet light A irradiation.

J Dermatol Treat 2000;11:105-107. 86) Sandler A, Silos S, Lowell B, Kirsner RS: Pemphigus vulgaris in a patient infected with HIV.

AIDS, Patient Care, and STDs 2000;14: 295-296. 87) Vensel E, Hilley T, Trent JT, Taylor JR, Kirsner RS, Kerdel FA, Taylor J, Schwartzberg J: Sustained improvement of quality of life after hospitalization for psoriasis.

J Amer Acad Derm 2000;43: 858-860.

88) Federman DG, Kirsner RS: Fatal bladder cancer and dermatomyositis. South Med J 2000;93: 492-493.

89) Schartzberg J, Kirsner RS: Stasis in venous ulcers: A misnomer that should be

abandoned. Dermatol Surg 2000;26: 683-684.

90) Litvak D, Kirsner RS, Pakdaman NN, Federman DG: Pyoderma gangrenosum and

myelodysplastic syndrome. S Med J 2000;93:923-925.

91) Brem H, Kirsner RS: Use of Graftskin (Apligraf) in the Treatment of Pressure Ulcers

and Acute Wounds. Wounds 2000;12:72A-77A

92) Bogensberger G, Eaglstein WH, Kirsner RS. Chronic leg ulcers in a patient with

combined arterial and venous disease successfully treated with a human skin equivalent: A case report.

Wounds 2000;12:118-121. 93) Federman DG, Kirsner RS. Fever and a rash in a 61 year old man.

Postgrad Med J 2000;76: 237, 243-4.

94) Greenberg JE, Lynn M, Kirsner RS, Hanly AJ. Clinical Practice. Mucocutaneous pigmentation due to zinc deposition.

Lancet 2000; 25 (356) (9244):1817.

95) Flores F, Eaglstein WH, Kirsner RS: Hydroxyurea-induced leg ulcer treated with Apligraf.

Ann Int Med 2000:132: 417-418. 96) Federman DG, Reid MC, Feldman SR, Greenhoe J, Kirsner RS: The primary care

provider and the care of skin disease: The patients perspective. Arch Derm 2001;137:25-29.

97) Valencia I, Falabella A, Kirsner RS, Eaglstein WH: Chronic Venous Insufficiency and

Venous ulceration. J Amer Acad Dermatol 2001;44:401-421.

98) Trent JT, Kirsner RS: Vasculitis: A Précis.

Advances in Skin and Wound Care 2001;14:64-70. 99) Federman DG, Kirsner RS: An update on hypercoagulable disorders.

Arch Int Med 2001;161:1-51-1056.

100) Kirsner RS, Federman DG: Atypical Wounds. Care Management 2001;7:2-3.

101) Kirsner RS, Orsted H, Wright JB: Matrix metalloproteinases in normal and impaired

wound healing: A potential role for nanocrystalline silver. Wounds 2001;13(Supple 3):S4-S13.

102) Kirsner RS, Federman DG: Interpretation of Cutaneous Biopsy Specimens: Choice of

Pathologist by Primary Care Practitioners South Med J 2001;94:461-463.

103) deAraujo TS, Kirsner RS: Vasculitis.

Wounds 2001;13:97-112. 104) Trent JT, Kirsner RS: Diagnosing Pyoderma Gangrenosum

Advances In Skin & Wound Care 2001;14:151-153. 105) Trent JT, Federman DG, Kirsner RS: Common Viral and Fungal Infections of the Skin

Ostomy/Wound Management 2001;47(6):28-34.

106) Trent JT, Federman DG, Kirsner RS: Common Bacterial Infections of the Skin Ostomy/Wound Management 2001;47(8):30-34.

107) Trent JT, Kirsner RS: Calciphylaxis: Diagnosis and Treatment Advances In Skin & Wound Care 2001;14:309-312.

108) Brooke A. Lowell BA, Froelich CW, Federman DG, Kirsner RS: Dermatology in

primary care: Prevalence and patient disposition.

J Am Acad Dermatol 2001;45:250-5. 109) Bello YM, Falabella AF, DeCarbalho H, Nayyar G, Kirsner RS: Infection and Wound

Healing. Wounds 2001;13:127-131.

110) Long RE, Falabella AF, Valencia I, Eaglstein WH, Kirsner RS: Treatment of refractory, atypical lower extremity ulcers with tissue engineered skin (Apligraf).

Arch Derm 2001;137:1660-1.

111) Federman DG, Moriarty JP, Kravetz JD, Kirsner RS: Thrombosis: New culprits in an old disorder.

Panminerva 2002;44:107-113. 112) Federman DG, Kirsner RS: Timing of hypercoagulable screens.

Arch Intern Med 2002;162:613-4. 113) Kirsner RS, Fastenau J, Falabella AF, Long R, Valencia I, Eaglstein WH: Clinical and

economic outcomes with graftskin for hard-to-heal venous leg ulcers: A single-center experience.

Derm Surg 2002;28:81-82. 114) Federman DH, Kravetz JD, Kirsner RS: Skin cancer screening by dermatologists:

Prevalence and barriers J Am Acad Dermatol 2002;46:710-4

115) Bello Y, Falabella AF, Kirsner RS, Elgart GE, Kerdel FA: Hypertensive Ulcers

Wounds 2002;14:131-135. 116). Valencia IC, Falabella A, Kirsner RS, Eaglstein WH: Venous Leg Ulceration

Phebology Digest 2002;15:6-11. 117) Trent JT, Kirsner RS: Diagnosing necrotizing fasciitis.

Advances In Skin and Wound Care 2002;15:135-138. 118) Federman DG, Kirsner RS: The patient with skin disease. An approach for non-

dermatologists.

Ostomy Wound Management 2002;48:22-28. 119) Sullivan TP, Kirsner RS: Surgical Pearl: Punch technique to improve granulation over

exposed tendons in chronic wounds. J Am Acad Dermatol. 2002;47:439-40.

120) Harrison-Balestra C, Eaglstein WH, Falabella AF, Kirsner RS: Recombinant human

platelet-derived growth factor for refractory nondiabetic ulcers: a retrospective series. Dermatol Surg. 2002;28:755-60.

121) Zacur H, Kirsner RS: Debridement: Rationale and Therapeutic Options

Wounds 2002;14(7 Supple E):2E-7E. 122) Sullivan TP, Elgart GW, Kirsner RS: Pemphigus and Smoking.

Int J Derm 2002;41:528-530. 123) Trent JT, Kirsner RS: Necrotizing Fasciitis.

Wounds 2002;14:284-292. 124) Greenberg JE, Lynn M, Kirsner RS, Elgart GW, Hanly AJ: Mucocutaneous pigmented macule as a result of zinc deposition

Journal of Cutaneous Pathology 2002;29:613-615. 125) Martin LK, Kirsner RS: Use of a meshed bilayered cellular matrix to treat a venous ulcer.

Adv Skin Wound Care 2002;15:260-264. 126) Banta MN, Kirsner RS: Modulating diseased skin with tissue engineering: actinic purpura

treated with apligraf. Dermatol Surg 2002;28:1103-6.

127) Li J, Zhang YP, Kirsner RS: Angiogenesis in wound repair: Angiogenic growth factors

and the extracellular matrix. Microscopy Research and Technique 2003;60:107-114.

128) Prins C, Kerdel FA, Padilla RS, Hunziker T, Chimenti S, Viard I, Mauri DN, Flynn K,

Trent T, Margolis DJ, Saurat JH, French LE, for the TEN-IVIG Study Group: Treatment of Toxic Epidermal Necrolysis With High-Dose Intravenous Immunoglobulins: Multicenter Retrospective Analysis of 48 Consecutive Cases

Arch Dermatol. 2003;139:26-32

129) Trent JT, Kirsner RS, Romanelli R, Kerdel FA: Analysis of Intravenous Immunoglobulin for the Treatment of Toxic Epidermal Necrolysis Using SCORTEN: The University of

Miami Experience. Arch Dermatol. 2003;139:39-43.

130) Geren SM, Kerdel FA, Falabella AF, Kirsner RS: Infliximab: A treatment option for ulcerative pyoderma gangrenosum

Wounds 2003;15:49-53. 131) Trent JT, Kirsner RS: Wounds and Malignancy

Adv Skin Wound Care 2003;16:31-34. 132) De Araujo T, Valencia I, Federman DG, Kirsner RS: Managing the patient with venous ulcers.

Ann Intern Med 2003;138:326-34. 133) Jacob SE, Lodha R, Cohen JJ, Romanelli P, Kirsner RS: Paraneoplastic eosinophilic

fasciitis: a case report. Rheumatol Int 2003;23:262-264.

134) Kirsner RS: Infection and Intervention.

Wounds 2003;15:127-128. 135) Drosou A, Falabella AF, Kirsner RS: Antiseptics on Wounds: An Area of Controversy.

Wounds 2003;15:149-166. 136) Kirsner RS: Wound Bed Preparation.

Ostomy Wound Manage 2003 Feb;Suppl:2-3. 137) Martin LK, Kirsner RS: Ulcers caused by bullous morphea treated with tissue-engineered

skin. Int J Dermatol 2003;42:402-4.

138) Trent JT, Kirsner RS: Identifying and treating mycotic skin infections.

Adv Skin Wound Care. 2003;16:122-9.

139) Banta MN, Eaglstein WH, Kirsner RS: Healing of refractory sinus tracts by dermal matrix injection with cymetra.

Dermatol Surg. 2003;29:863-6. 140) Ayyalaraju RS, Finlay AY, Dykes PJ, Trent JT, Kirsner RS, Kerdel FA: Hospitalization

for severe skin disease improves quality of life in the United Kingdom and the United States: A comparative study.

J Am Acad Dermatol. 2003;49:249-54. 141) Sullivan TP, Welsh E, Kerdel FA, Burdick AE, Kirsner RS: Infliximab for Hidradenitis

Suppurativa. Br J Dermatol 2003;149:1046-1049.

142) Trent JT, Kirsner RS: Herpesvirus infections and herpetic wounds.

Adv Skin Wound Care. 2003;16:236-243. 143) Thomas- Hess C, Kirsner RS: Orchestrating Wound Healing: Assessing and preparing

the Wound Bed. Adv Skin Wound Care. 2003;16:246-259.

144) Federman DG, Kirsner RS, Moriarty JP, Concato J: The effect of antibiotic therapy for

patients infected with Helicobacter pylori who have chronic urticaria. J Am Acad Dermatol. 2003;49:86-864.

145) Federman DG, Kravetz JD, Kirsner RS: An Interesting Side Effect of Home Oxygen Therapy.

Ostomy Wound Manage. 2003;49:26-27 146) Trent JT, Kirsner RS: Epidermolysis bullosa: identification and treatment.

Adv Skin Wound Care. 2003;16:284-90. 147) Rongioletti F, Borenstein M, Kirsner R, Kerdel F: Erythrodermic, recalcitrant psoriasis:

clinical resolution with infliximab. J Dermatolog Treat. 2003;14:222-5.

148) Hess CT, Kirsner RS: Uncover the latest techniques in wound bed preparation.

Nurs Manage. 2003;34:54-6. 149) Trent JT, Federman D, Kirsner RS: Skin and wound biopsy: when, why, and how.

Adv Skin Wound Care. 2003; 16:372-5. 150) Drosou A, Kirsner RS, Welsh E, Sullivan TP, Kerdel FA: Use of infliximab, an anti-

tumor necrosis alpha antibody, for inflammatory dermatoses. J Cutan Med Surg. 2003;7:382-6.

151) Trent JT, Kirsner RS: Cutaneous Manifestations of Diabetic Disease.

ECPN. 2003; 30-35. 152) Federman DG, Kravetz JD, Kirsner RS: Necrotizing fasciitis and cardiac catheterization.

Cutis. 2004;73:49-52. 153) Hu S, Ma F, Collado-Mesa F, Kirsner RS: Ultraviolet radiation and incidence of non-

Hodgkin's lymphoma among Hispanics in the United States. Cancer Epidemiology, Biomarkers and Prevention. 2004;13:59-64

154) Federman DG, Kravetz JD, Ruser CB, Judson PH, Kirsner RS: Vogt-Koyanagi-Harada

syndrome and ulcerative colitis.

South Med J. 2004;97:169-71. 155) Federman DG, Bravata DM, Kirsner RS: Peripheral arterial disease: a systemic disease

extending beyond the affected extremity. Geriatrics 2004; 59: 26-36.

156) Federman DG, Kravetz JD, Tobin DG, Ma F, Kirsner RS: Full body skin examinations:

The patient’s perspective. Arch Dermatol 2004;140:530-534.

157) Federman DG, McNiff JM, Kirsner RS: Pancreatic panniculitis.

Wounds 2004;16:140-146. 158) Trent JT, Kirsner RS: Cutaneous Manifestations of HIV: A Primer.

Adv Skin Wound Care. 2004;17:116-127. 159) Trent JT, Kirsner RS: Cutaneous Manifestations of HIV: A Primer.

Adv Skin Wound Care. 2004;17:127-9. 160) Ramirez CC, Kirsner RS: A refractory case of erythromelalgia involving the ears.

Amer J Otolaryngology- Head and Neck Medicine 2004;25:251-254. 161) Brem H, Kirsner RS, Falanga V: Protocol for the successful treatment of venous ulcers.

Am J Surg. 2004;188(1A):1-8. 162) Boulton AJM, Kirsner RS, Vileikyte L: Neuropathic Diabetic Foot Ulcers.

New Engl J Med 2004;351:48-55. 163) Charles CA, Bialy TL, Falabella AF, Eaglstein WH, Kerdel FA, Kirsner RS: Poor

prognosis of arthritis associated pyoderma gangrenosum. Arch Derm 2004;140:861-864.

164) Trent JT, Kirsner RS, Romanelli P, Kerdel FA: Use of SCORTEN accurately predict

mortality in patients with Toxic Epidermal Necrolysis in the United States, Arch Derm 2004;140:890-892.

165) Hu S, Ma F, Collado-Mesa F, Kirsner RS: Ultraviolet Radiation, Latitude and Melanoma

in US Hispanics and Blacks. Arch Derm 2004;140:819-824.

166) Armstrong DG, Attinger CE, Boulton AJ, Frykberg RG, Kirsner RS, Lavery LA, Mills

JL: Guidelines regarding negative wound therapy (NPWT) in the diabetic foot. Ostomy Wound Manage. 2004;50:3S-27S.

167) Valencia IC, Kirsner RS, Kerdel FA: Microbiologic evaluation of skin wounds: alarming trend toward antibiotic resistance in an inpatient dermatology service during a 10-year period.

J Am Acad Dermatol. 2004;50:845-9. 168) Charles CA, Kato T, Tzakis AG, Miller BN, Kirsner RS: Use of A Living Dermal

Equivalent for A Refractory abdominal Defect after pediatric multi-visceral transplantation.

Derm Surg 2004;30:1236-40.

169) Green AR, Elgart GW, MA, F, Federman DG, Kirsner RS: Documenting Dermatology Practice: Ratio of cutaneous tumors biopsied which are malignant.

Derm Surg 2004;30:1208-9.

170) Federman DG, Kirsner RS: Inglorius "Old Glory". Connecticut Medicine 2004;68:653.

171) Poochareon V, Federman DG, Kirsner RS: Primary Prevention Efforts for Melanoma

J Drugs Dermatol 2004:3:506-519. 172) Trent JT, Kirsner RS: Leg Ulcers in Sickle Cell Disease. Adv Skin Wound Care. 2004;17:410-416 173) Martin L, Romanelli R, Ahn Y, Kirsner RS: Telangiectasia macularis eruptiva perstans

with an associated myeloproliferative disorder Int J Dermatol 2004;43:922-924.

174) Hu S, Parker D, Thomas AG , Kirsner RS: Advanced Presentation of Melanoma in

African American: The Miami Dade County Experience. J Amer Acad Dermatol 2004;51:1031-1032.

175) Levy D, Banta MR, Charles CA, Eaglstein WH, Kirsner RS: Cymetra: A Treatment

Option for Refractory Ulcers Wounds 2004;16:359-363.

176) Prodanovich S, Ma F, Taylor JR, Pezon C, Fasihi T, Kirsner RS: Methotrexate Reduces

Incidence of Vascular Diseases in Veterans with Psoriasis or Rheumatoid Arthritis J Am Acad Dermatol. Accepted for publication

177) Ramirez CC, Federman DG, Kirsner RS: Skin Cancer as an Occupational Disease.

Int J Dermatol Accepted for Publication.

178) Hu S, Federman DG, Ma F, Kirsner RS: Skin Cancer and non-Hodgkin’s Lymphoma: Examining the link

Derm Surg In Press

179) Schartzberg JB, Elgart GW, Romanelli P, Ma F, Federman DG, Kirsner RS: Accuracy

and Predictors of Basal Cell Carcinoma Diagnosis Derm Surg In Press

180) Drosou A, Kirsner RS, Kato T, Mittal N, Al-Niami A, Miller B, Tzakis AG: Use of a

bioengineered skin equivalent for the management of difficult skin defects after pediatric multivisceral transplantation

J Amer Acad Derm In Press 181) Kirsner RS, Parker DF, Brathwaite N, Thomas A, Tejada F, Trapido EJ: Sun Protection

Policies in Miami-Dade County Public Schools: Opportunities for Skin Cancer Prevention.

Pediatric Derm In Press OTHER WORKS, PUBLICATIONS AND ABSTRACTS 1) Sawaya ME, Kirsner RS, Nemeth AJ, Weiss DS, Hsia SL: Elevated type II

glucocorticoid receptor binding in keloids and hypertrophic scars. JID 94, 1990. Clin. Res. 38; 1990. 2) Sawaya ME, Price VH, Harris KA, Kirsner RS, Hsia SL: Human hair follicle aromatic

activity in females with androgenetic alopecia. JID 94; 1990. Clin. Res. 38; 1990. 3) Kirsner RS, Katz MH, Falanga V: Hypoxia induced stimulation of single fibroblast

growth in vitro and its inhibition by suramin. JID 96; 1991. Clin. Res. 39; 1991.

4) Katz MH, Alvarez AF, Kirsner RS, Falanga V: Endothelin-1 is a growth factor for

fibroblasts. JID 96; 1991. Clin. Res. 39; 1991. 5) Kirsner RS, Pardes JB, Ochoa S, Martin TA, Falanga V: Oxygen tension controls

collagen type I transcription. JID 98; 1992. Clin. Res. 40; 1992. 6) Pardes JB, Kirsner RS, Ochoa S, Martin TA, Falanga V: TGF- beta 1 is a potent inhibitor

of human dermal fibroblasts. JID 98; 1992. Clin. Res. 40; 1992. 7) Carson PA, Kirsner RS, Pardes JB, Falanga V: Evaluation of sorbsan in the treatment of

venous ulcers. Wounds 1992; 4: 30-31.

8) Higley H, Ksander G, Gerhart C, Kirsner RS, Falanga V: Immunocytochemical analysis

of growth factor and growth factor response cells in chronic venous stasis ulcers. Wounds 1992; 4: 33-34. 9) Helfman T, Kirsner RS, Pardes J, Takagi H, Ochoa S, Martin T, Falanga V:

Transcriptional regulation of TGF-Beta 1 (TGF-Beta) and alpha 1 (1) Procollagen gene in hypoxic fibroblasts.

JID 100; 1993. Clin. Res. 41; 1993. 10) Kirsner RS, Falanga V: Features of an autoimmune process in mid-dermal elastolysis. In:

The Yearbook of Dermatology 1993. Eds. Arthur J. Sober and Thomas B. Fitzpatrick. 11) Kirsner RS, Eaglstein WH, Katz MH, Kerdel FA, Falanga V: Stanozolol causes rapid

pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia. In: The Yearbook of Dermatology 1994. Eds. Arthur J. Sober and Thomas B. Fitzpatrick.

12) Bieley HC, Kirsner RS, Reyes BA, Garland LD: The use of Mohs Micrographic Surgery for determination of residual tumors in incompletely excised basal cell carcinomas. In: The Yearbook of Dermatologic Surgery 1994. Eds. Neil A. Swanson, Richard G. Glogau, and Stuart J. Salashe. 13) Falanga V, Eaglstein WH, Kirsner RS: Recurrent Cellulitis (Letter Reply). J Am Acad Dermatol 1994; 30: 676. 14) Machler BC, Kirsner RS, Elgart GW: Routine histology for the diagnosis of

onychomycosis: Evaluation of sensitivity and specificity. J Cutan Pathol 1995; 22: 71

15) Sherendiah S, Kirsner RS, Valenzuela R: Epidermolysis Bullosa

Acquisita. Immunopathology Check Sample No IP 95-3 (IP-III)

Am Soc Clin Pathol 1995. 16) Kirsner RS: Systemic agents which affect wound healing. J Dermatol Treat 1996; 7:62

17) Kirsner RS: Gene Therapy. J Dermatol Treat 1996; 7: 60.

18) Hurwitz D, Kirsner RS, Falanga V, Elgart GW: The pathologic spectrum of

lipodermatosclerosis. J Cutan Pathol 1996; 23:78.

19) Federman DG, Hogan D, Taylor JR, Caralis PV, Kirsner RS: A comparison of

diagnosis, evaluation and treatment of patients with dermatologic disorders. In: The Yearbook of Dermatology 1996. Eds. Arthur J. Sober and Thomas B. Fitzpatrick.

20) Kirsner RS, Mata SM, Falanga V, Kerdel FA: Split-thickness skin grafting of leg ulcers. The University of Miami Dermatology's Experience (1990-1993). In: The Yearbook of Dermatology 1996. Eds. Arthur J. Sober and Thomas B. Fitzpatrick. 21) Federman DG, Concato J, Caralis PV, Hunkele G, , Kirsner RS: The frequency of skin cancer screening examinations compared to other cancer screening examinations by primary care providers.

J Invest Dermatol 1997;108:363.

22) Kirsner RS, Federman DG: Lack Of Correlation Between Internists’ Ability in Dermatology And Their Patterns Of Treating Patients With Skin Disease.

Amer J Managed Care 1997;3:390. 23) Federman DG, Kirsner RS: Primary care in dermatology (Letter).

J Am Acad Dermatol 1997;37:668. 24) Kirsner RS: Outcomes: Are clinicians ready.

Ostomy/Wound Management 1998;44:4-6.

25) Kirsner RS: Apligraf treatment for acute wounds. J Dermatol 1998;108:486.

26) Elgart G, Valencia IC, Hurwitz D, Kirsner R, Falanga V, Eaglstein WH: Lipodermatosclerosis: The histological spectrum.

J Cut Pathol 1998;25:494. 27) Kerdel FA, Kirsner RS: Who should care for hospitalized patients with severe skin disease (Letter).

Arch Dermatol 1998;134:1159. 28) Kirsner RS, Federman DG: Dermatology education for internists (Letter).

Arch Int Med 1998;158:1952-1953. 29) Hanly AJ, Valencia IC, Badiavas E, Kirsner R, Elgart GW: Dual infections in an AIDS patient masquerading as squamous cell carcinoma: Light, immunohistochemical and electron microscopic evaluation.

J Cut Pathol 1998;25:497. 30) Federman DG, Kirsner RS: Skin biopsies, cutaneous disease, and primary care (Letter).

Ann Int Med 1999;130:617.

31) Pacheco HA, Riley GS, Potosky S, Federman DG, Kirsner RS: Differences in melanoma stage between HMO and FFS are due to access to health care.

J Invest Dermatol 1999;112:531. 33) Ayyalaraju RSA, Finlay AY, Kirsner RS, Trent JT, Kerdel FA: Dermatology Inpatient Services UK/USA Comparative Study.

Br J Dermatol 1999;141(Suppl 55):79-80. 34) Kerstein MD, Kirsner RS, Norman RA, Phillips TA: How to approach acute and chronic wound healing in the elderly.

Wounds 1999; 11:145-151. 35) Ayyalaruji RS, Finlay AY, Dykes PJ, Trent JT, Kerdel FA, Kirsner RS: Dermatology

inpatient services. A UK/USA comparison study. J Invest Dermatol 2000;114: 886.

36) Eaglstein WH, Kerdel FA, Elgart GE, Kirsner RS, Muhart M: A controlled trial, LSE vs.

Killed LSE, is needed (Letter Reply). Arch Dermatol 2000;136: 555-556.

37) Kirsner RS, Valencia I, Falabella AF, Eaglstein WH: About the pathophysiology of

venous leg ulceration (Letter Reply). J Amer Acad Dermatol 2002;47:158. 38) Kirsner R: New approaches to a timeless dilemma.

Ostomy Wound Management 2003;49:12-14. 39) Kirsner R: Wound Bed Preparation.

Ostomy Wound Management 2003;Suppl Feb:2-3. 40) Trent JT, Kirsner RS, Romanelli P, Kerdel FA: Scoring with Scorten (Letter Reply)

Arch Derm 2003;139:1215-1216. 41) Federman DG, Kirsner RS: A Rash Decision (letter).

Ann Int Med 2003;139:869. 42) Sullivan TP, Kirsner RS: Punch technique to improve granulation over exposed tendons

in chronic wounds (Letter Reply). J Am Acad Dermatol 2004;50:e7

43) Boulton AJM, Kirsner RS, Vileikyte L: Neuropathic Diabetic Foot Ulcers (Letter Reply). New Engl J Med 2004;351:1694-1696.

AMERICAN ACADEMY OF DERMATOLOGY PUBLICATIONS AS A MEMBER OF THE GUIDELINES/OUTCOMES COMMITTEE 1) Guidelines of care for liposuction. J Amer Acad Derm 2001;45:438-47. 2) Guidelines of care for primary cutaneous melanoma. J Amer Acad Derm 2001;45:579-86. INTERNET PUBLICATIONS 1) Kirsner RS, Yang D, Kerdel FA: Admission of patients with skin disease to the hospital (Letter Reply).

J Amer Acad Derm 2001Published January 12, 2001 doi:10.1067/mjd.2001.112356

CME PROGRAM 1) Treadwell T, Kirsner RS: Medical Simulations in wound care management. InterMed

Press, Darien, Connecticut. 2) Kerdel FA, Kirsner RS: Cutaneous and oral manifestations of HIV and AIDS. A CME Series. COMPUTER PROGRAM 1) Kirsner RS, Anhalt GJ, Kerdel FA: Treatment with alpha-interferon associated with the

development of Paraneoplastic Pemphigus. Teachings in Dermatology Volume I. Mosby Publisher, St. Louis, 1994.

V. PROFESSIONAL GRANTS RECEIVED WITHIN PAST FIVE YEARS (Principal Investigator) 06/92 World Congress of Dermatology $ 1,000 07/95 Dermatology Foundation $ 120,000 Career Development Award For Health Care Policy

01/01 American Skin Association $15,000 The Effect of Health Care Delivery Systems

On Outcomes of Patients With Melanoma 01/03 American Cancer Society $50,000 Cancer Among Indigent Populations In South Florida:

The relationship between Poverty, Cancer Rates and Medical Services

8/03 National Cancer Institute $50,000 NIH U01-CA86117 $50,000 Perception of risk of skin cancer in Hispanic students

9/04 National Cancer Institute $1,500,000 R25 CA109392-01 SunSmart America: Evaluating a School Based Curriculum

CLINICAL RESEARCH STUDIES WITHIN THE PAST FIVE YEARS

2002 – Present Therapy for Dyslipidemia in Patients with Peripheral Vascular Disease

P.I. 2002 – Present A Double-Blind Randomized, Vehicle-Controlled Sequential Dose

Escalation Study Assessing the Safety, Clinical Pharmacology, Systemic Disposition and Pharmacokinetics of MRE 0094 Gel Versus Matching Vehicle Gel when Applied Topically to subjects with Diabetic, Neuropathic, Foot Ulcers

P.I. Funding Goal: $ 52,500 2002 – Present A Randomized, Placebo-Controlled, Blinded, Multicenter, Phase

III Study of Photodynamic Therapy with Verteporfin for Injection (VFI) for the Treatment of Multiple Basal Cell Carcinoma

P.I. Funding Goal $ 50,000

2002 – Present A Randomized, Double-Blind, Placebo-Controlled Trial to Assess Three Dose Levels of Rosiglitazone Maleate in the Treatment of Moderate to Severe Plaque Psoriasis

P.I. Funding Goal $

2002- Present A Prospective, Randomized, Double-Blind, Multicenter Trial Assessing the Safety and Efficacy of Moxifloxacian for the Treatment of Patients with Complicated Skin and Skin Structure Infections

Sub. P.I. Funding Goal $ 40,000

2002- Present Topical Tretinion Chemotherapy Trail

P.I. VA Consortium Study

2002- Present A Multi-Center, Epidemiology Study to Evaluate the Potential for Adverse Health Effect in Fetuses and Live-Born Infants Following a Women’s Inadvertent Exposure to Tazarotene Cream or Gel for Psoriasis During Pregnancy Compared with a Similar Group of Psoriatic Women not Exposed to Tazarotene and Compared with Background levels in the General Population

P.I. Funding Goal $ 20,000

2002- Present Linezolid vs. Vancomycin for the Treatment of Complicated Skin

and Soft Tissue Infection Suspected of Being or Proven to Be Due to a Methicillin Resistant Gram-Positive Bacterial Pathogen

Sub- P.I. Funding Goal $ 50,000

2002- Present A Pivotal Randomized Study to Examine the Safety and Efficacy

of a Collagen Matrix Containing Allograft Cells for the Treatment of Venous Ulcers

P.I. Funding Goal $ 45,000

2002 - Present Multicenter Dose Ranging Study of the Safety and Efficacy of

Enbrel in Psoriasis. P.I. Funding Goal $ 10,000

2002- Present A Phase 2, Multicenter, Randomized Double-Blind, Placebo-

Controlled Trail Evaluating the Efficacy and Safety of Inflixmab (REMICADE) Induction Therapy in Patients with Plaque-type Psoriasis

P.I. Funding Goal $ 65,000

1999- Present A Randomized, Double-Blind, Placebo Controlled Multicenter Study of Keratinocyte Growth Factor-2 (KGF-2) to Evaluate Safety And Efficacy on Acceleration of Wound Healing in Chronic Venous Ulcer Subjects Following Topical Administration to the Wound Twice Weekly for Twelve Weeks P.I. Funding Goal $120,000

1999- 2002 Randomized, Double-Blind Placebo Controlled Dose Ranging Clinical Trial to Evaluate the Safety and Efficacy of Oxandrolone in the Treatment of Pressure Ulcers in Patients with Weight Loss. P.I. Funding Goal $49,438.00

1998 – 2000 IBAH/Pharmacia & Upjohn: Linezoid vs. Oxacillin

Sodium/Dicloxacillin Sodium for the Treatment of Complicated Skin and Soft Tissue Infection

1999- 2000 A Multicenter Investigator Blinded, Randomized Study to Compare the Safety and Efficacy of IV Daptomycin with that of Vancomycin or a Semi – Synthetic Penicillin in the Treatment of Complicated Bacterial Skin and Soft Tissue Infections Due to Gram Position Bacteria Sub-PI Funding Goal $30,000

1998 – 1999 Phoenix Group/TAP Holdings, Inc.: CDTR vs. Deftin in the Treatment of Uncomplicated Skin Infection

Sub-PI Funding $5,000

1998 – 1999 Pharmacia & Upjohn: Linezoid vs. Vancomycin in the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Infection

P.I. Funding $10,000

1998 – 2000 Pharmacia & Upjohn: Treatment of Complicated Skin and Soft Tissue Infection M/1260-0039

Sub-PI Funding $10,000

1997 – 1999 Pharmacia & Upjohn: Treatment of Uncomplicated Skin and Soft Tissue Infection

Sub-PI Funding $10,000

1999- 2000 Pilot Study, Within-Subject Controlled Study to Evaluate the

Persistence of Graftskin in Split-Thickness Wounds Sub-PI Funding $50,000

1999 – 2000 The Effects of Three Bandages in the Treatment of Partial-

Thickness Wounds P.I. Funding $26,000

1996 - 1997 Park Davis Pharmaceuticals: An Investigator Blind Study of Clinafloxacin vs. Piperacillin/Tazobactam in the Treatment of Complicated Skin and Soft Tissue Infections (SSTI)

PI Funding $10,000

EDITORIAL RESPONSIBILITIES Editor

1997 - 1999 Co-Clinical Editor - Ostomy/ Wound Management 1998 - 1999 Editor - CME supplement - Wounds 1997 – 2000 Editorial Board Member- Centers for Wound Healing Excellence 1999 - 2001 Editor - Current Topics In Wound Healing - Newsletter

1999 - Present Consulting Editor - Ostomy/ Wound Management 2000 – Present Section Editor - Wounds 2002 – Present Editor – CME supplement – Wounds 2003 – Present Assistant Editor on Wound Healing – Dermatologic Surgery

Editorial Board 1997 – Present Ostomy/Wound Management

2000 - Present Wounds 2003 – Present Dermatologic Surgery 2003 - Present Skin and Aging

Reviewer

1993 - Present Reviewer - Archives of Dermatology 1995 - Present Reviewer - The American Journal Managed Care

1996 - Present Reviewer - Journal of the American Academy of Dermatology 1997 - Present Reviewer - Advances in Skin and Wound Care 1997 - Present Reviewer - Ostomy/Wound Management

1997 - Present Reviewer - Wounds 1998 - Present Reviewer - American Journal of Medicine 1998 - Present Reviewer - Southern Medical Journal 1999 - Present Reviewer - American Family Physician 1999 - Present Reviewer - Journal of the American Medical Woman’s Association 2000 – Present Reviewer – Dermatologic Surgery 2000 – Present Reviewer – Diabetes Care

2001 – Present Reviewer - Journal of the European Academy of Dermatology and Venereology

2001 – Present Reviewer - American Journal of Clinical Dermatology 2001 – Present Reviewer – International Journal of Dermatology

2001 – Present Reviewer – American Journal of Epidemiology 2002 – Present Reviewer – Nature Medicine 2002 – Present Reviewer – Lancet 2002 – Present Reviewer – Mayo Clinic Proceedings 2003 – Present Reviewer – Pediatric Dermatology 2003 – Present Reviewer – Journal of the European Academy of Dermatology 2004 – Present Reviewer – Molecular Therapy SOCIETY MEMBERSHIPS 1984 - Present American Medical Association 1995 - Present Fellow, American Academy of Dermatology 1995- Present Florida Society of Dermatology and Dermatologic Surgery

1996 - Present International DermatoEpidemiology Association Medical Dermatology Society Association for the Advancement of Wound Care Society of Investigative Dermatology La Sociaedad Chilena De Dermatologia Y Venereologia

Residency Curriculum Exchange Group 1998 - Present Wound Healing Society

European Society for Tissue Repair 1999 - Present Miami Dermatological Society 2000 – Present Argentinian Medical Association OTHER PROFESSIONAL ACTIVITIES

07/95 - 7/96 Physician Consultant Skin Care Attack Team (SCAT)

Jackson Memorial Hospital

09/95 - Present Board of Directors - Founding member The Association for the Advancement of Wound Care

02/97 - Present Board Member CME Advisory Committee Health Management Publications 04/97-Present Board Member Accreditation Advisory Board American Academy of Wound Management 09/96-09/97 Member: International Committee Reunion Internacional de Terapeutic Dermatologica San Salvador, El Salvador 09/96- Present Member: International Committee Dermatology Therapy International

10/97-Present Board Member American Academy of Wound Management

12/97-12/00 Director: Wound Healing Preceptorship Ortho-McNeil Pharmaceuticals 01/00- 01/03 Membership chairperson Miami Dermatological Society

04/98- 04/00 Treasurer Association for the Advancement of Wound Care 04/00- 4/02 President- Elect Association for the Advancement of Wound Care 04/02- 4/04 President Association for the Advancement of Wound Care

05/04- Present Immediate Past President Association for the Advancement of Wound Care 05/03 -Present Member, Board of Directors Florida Society of Dermatology and Dermatologic Surgery 06/04 -Present Vice- President Florida Society of Dermatology and Dermatologic Surgery EXAMINING BOARD MEMBERSHIPS "Not applicable"

STUDY SECTION AND COUNCIL MEMBERSHIPS 04/94 - Present Chairperson Planning Committee

Advanced Wound Care Symposium Medical Research Forum

07/95 - 02/97 Special Consultant

Quality of Care Committee American Academy of Dermatology

07/96 – 3/01 Member Cost-Effectiveness Task Force American Academy of Dermatology 02/97- 3/04 Member Quality of Care Committee American Academy of Dermatology 01/99- Present Member

Health Policy Committee Medical Dermatology Society 02/99- 4/00 Member

Medical Dermatology Sub Group Program for Dermatology for the 21st Century American Academy of Dermatology

02/99- 4/00 Member Fair Valuation Sub Group Program for Dermatology for the 21st Century American Academy of Dermatology 07/99 - Present Co-Chairperson

Advanced Wound Care Symposium Medical Research Forum

04/00- Present Member Guidelines Committee American Academy of Dermatology 05/03- Present Member and Executive Board Member Florida Cancer Control and Research Advisory Council 02/04- 8/04 Chair Quality of Care Committee

American Academy of Dermatology 08/04- Present Co-chair Practice Management Task Force 011/04- Present Chair Quality Assurance/Quality Improvement Task Force CONSULTANSHIPS

"Not applicable"

HONORS AND AWARDS 07/85 NATIONAL INSTITUTES OF HEALTH Summer Fellowship 11/91 UPJOHN CORP. Young Investigator Award 06/95 George Ioannides Teaching Award 06/96 Most Valuable Player Award 1996 Dermatology Resident Class 1998, 1999 Best Doctors in America

2002 1998 United Way of Dade County Nominee: Monsignor Walsh Outstanding Human Services Professional Award 1998, 1999 Best Doctors in South Florida 1999 Camillus House Special Award for In Kind Giving 1999 Award for Excellence in Teaching: GEST Program: Co-Director American Academy of Dermatology 1999 Deans Award for Clinical Research Investigator: Junior Faculty University of Miami School of Medicine 1999 Teaching Award University of Miami School of Medicine

2000 Who’s Who in Healthcare and Medicine 2001 Resident Teaching Award

University of Miami Department of Dermatology 2002 Alpha Omega Alpha (AOA) Visiting professorships Visiting Professor. University of South Florida College of Medicine, Dermatology and

Cutaneous Surgery/Florida West Coast Society Meeting, August 08, 1995, Tampa, Fl.

Visiting Lecturer. Panama Canal Commission, August 19-20, 1996, Panama City, Panama. Visiting Professor. St. Louis University School of Medicine, Department of Dermatology, November 11-12, 1998, St. Louis, MO.

Visiting Professor. Oregon Health Sciences University, Dermatology/Oregon Dermatology Meeting, February 11-12, 2003, Portland, Oregon.

Scientific presentations at national and international meetings Scientific Exhibit: Elevated type II glucocorticoid receptor binding in keloids and

hypertrophic scars. Sawaya ME, Kirsner RS, Nemeth AJ, Weiss DS, Hsia SL; May 02-05, 1990, The Society of Investigative Dermatology, Washington, D.C. Symposium: Residents and Fellows Symposium. American Academy of Dermatology. December 01-04, 1990, Atlanta, Ga.

Scientific Exhibit: Human Hair follicle aromatase activity in females with androgenetic

alopeica. Sawaya ME, Price VH, Harris KH, Kirsner RS, Hsia SL; May 02-05, 1990, The Society of Investigative Dermatology, Washington, D.C. American Academy of Dermatology December 01-04, 1990, Atlanta, Ga.

Scientific Exhibit: Hypoxia induced stimulation of single fibroblast growth and its

inhibition by suramin. Kirsner RS, Katz MH, Falanga V; May 01-04, 1991, The Society of Investigative Dermatology, Seattle Washington, American Academy of Dermatology December 06-11, 1991, Dallas, Tx.

Scientific Exhibit: Endothelin-1 is a growth factor for fibroblasts. Katz MH, Alvarez

AF, Kirsner RS, Falanga V; May 01-04, 1991, The Society of Investigative Dermatology, Seattle, Wash.

Scientific Exhibit: Evaluation of Sorbsan in the treatment of venous ulcers. Carson PA,

Kirsner RS, Pardes JB, Falanga V; April 23-25, 1992, Advanced Wound Care

Symposium, New Orleans, LA.

Scientific Exhibit: Immunocytochemical analysis of growth factor and growth factor response cells in chronic venous stasis ulcers. Higley H, Ksander G, Gerhart C, Kirsner RS, Falanga V; April 23-25, 1992, Advanced Wound Care Symposium, New Orleans, LA. (Outstanding Scientific Presentation).

Scientific Exhibit: Oxygen tension controls collagen type I transcription. Kirsner RS,

Pardes JB, Ochoa S, Martin TA, Falanga V; April 29-May 03, 1992, The Society of Investigative Dermatology, Baltimore, MD.

Symposium: Leg ulcers due to cryofibrinogenemia. Kirsner RS, Kerdel FA, Eaglstein WH, Katz MH, Falanga V; June 13, 1992, World Congress of Dermatology, New York, N.Y.

Scientific Exhibit: Novel treatment of Erythema Multiforme Major and Toxic Epidermal Necrolysis with silver nitrate impregnated soft sorb dressings. Tallman P, Kirsner RS, Kerdel FA; September 15, 1994, Conference on Toxic Epidermal Necrolysis, Creteil, France. American Academy of Dermatology, February 04-09, 1995, New Orleans, LA. Dermatological Therapy International, September 1-4, 1995, Miami, FL.

Scientific Exhibit: Routine histology for diagnosis of onychoymycosis: Evaluation of

sensitivity and specificity. Machler BC, Kirsner, RS, Elgart GW; February 01-03, 1995, American Society of Dermatopathology, New Orleans, LA.

Symposium: Treatment with alpha-interferon associated with the development of Paraneoplastic Pemphigus. Kirsner RS, Anhalt GJ, Kerdel FA, December 04, 1993, American Academy of Dermatology, Washington, D.C.

Symposium: Wound Care Management for dermabrasion. Kirsner RS, February 05,

1995, American Academy of Dermatology, New Orleans, LA. Symposium: Lipodermatosclerosis. Kirsner RS, July 28, 1995, Summer American

Academy of Dermatology, Chicago, IL. June 2, 1996 Florida Society of Dermatology, Key Biscayne, FL.

Symposium: Gene Therapy. Kirsner RS, September 03, 1995, Dermatological Therapy International, Miami, FL. September 06, 1996, VI Encuentros Internationales De Dermatologia, II Curso Intenational Terapeutica Dermatologica, Santiago, Chile.

Symposium: Systemic Agents which affect Wound Healing. Kirsner RS, September 03, 1995, Dermatological Therapy International, Miami, FL. April 22, 1996, Advanced Wound Care Symposium, Atlanta, Georgia. September 06, 1996, VI Encuentros Internationales De Dermatologica, II Curso International Terapeutic Dermatologica, Santiago, Chile.

Scientific Exhibit: The pathologic spectrum of Lipodermatosclerosis. Hurwitz DH, Kirsner RS, Falanga V, Elgart GW, February 07-09, 1996, American Society of Dermatopathology, Washington, DC. Scientific Exhibit: A comparison of living skin equivalent (LSE), autograft, and occlusive film dressing in the treatment of split-thickness skin graft donor sites. Muhart M, Kerdel FA, Kirsner RS, McFalls SM, Eaglstein WH, May 1-5, 1996, Society of Investigative Dermatology, Washington, DC. Scientific Exhibit: The prevalence of cancer screening examinations performed by internists and medical residents. Hunkele GE, Caralis PV, Kirsner RS, Federman DG, July 26, 1996. Summer Science Scholars Poster Session, Miami, Fl. Symposium: Life Threatening Skin Infections. Kirsner RS. July 25, 1996. Summer American Academy of Dermatology Meeting. Orlando, Fl Symposium: Where do we stand with systemic dermatologic therapy? Kirsner RS. July 26, 1996. Summer American Academy of Dermatology Meeting. Orlando, Fl. Symposium: Pulse Steroid Therapy. Kirsner RS. September 06, 1996. VI Encuentros Internacionales De Dermatologica, II Curso Internacional Terapeutica Dermatologica, Santiago, Chile. Symposium: Split Thickness Skin Grafting: Techniques, results, theory. Kirsner RS. September 06, 1996, VI Encuentros Internacionales De Dermatologica, II Curso Internacional Terapeutica Dermatologica, Santiago, Chile. Scientific Exhibit: Apligraft for split-thickness skin graft donor sites. Muhart M, McFalls SG, Kirsner RS, Elgart GW, Kerdel FA, Eaglstein WH, October 29-31, 1996. Wound Management Conference, Tuscon, Arizona. First Place Scientific Exhibit: The prevalence of skin cancer screening among primary care providers. Federman DG, Hunkele G, Caralis PV, Kirsner RS, March 20, 1997. International DermatoEpidemiology Association, San Francisco, CA. Symposium: Business Issues: Quality of Care in Dermatology. Kirsner RS. March 21, 1997, American Academy of Dermatology, San Francisco, CA. Symposium: Skin cancer screening in primary care. Federman DG, Concato J, Caralis PV, Hunkele GE, Kirsner RS. July 24, 1997, Florida Epidemiology Meeting, Miami, FL. Symposium: Wound healing: Grafting for chronic wounds. Kirsner RS. February 27, 1998 American Academy of Dermatology, Orlando, FL.

Focus Session: Inpatient Dermatology. Kirsner RS. February 28, 1998 American Academy of Dermatology, Orlando, FL. March , 1999, New Orleans, LA Symposium: Skin signs of systemic disease. What Dermatologists Should Know About Lupus in 1999. Kirsner RS. March , 1999 American Academy of Dermatology. Symposium: Apligraf in the treatment of acute wounds. Kirsner RS. May 29, 1998. Japanese Dermatological Association, Osaka, Japan. Symposium: What’s New In Wound Healing. Kirsner RS. July 24, 1998 IV Reuniao International de Terapeutica Dermatologica, Brasilia, Brasil. August 3, 1998 American Academy of Dermatology Summer Meeting, Chicago, IL. Symposium: Dermatologic Uses of Intravenous Immunoglobulin. Kirsner RS. July 24, 1998 IV Reuniao International de Terapeutica Dermatologica, Brasilia, Brasil. Symposium: Combination Therapy for Psoriasis. Kirsner RS. July 23, 1999 V Reuniao International de Terapeutica Dermatologica, Monterrey, Mexico. Symposium: Treatment of Cutaneous Lupus. Kirsner RS. July 23, 1999 V Reuniao International de Terapeutica Dermatologica, Monterrey, Mexico Symposium: Complications of Pulse CO2 Laser Therapy. Kirsner RS. July 23, 1999 V Reuniao International de Terapeutica Dermatologica, Monterrey, Mexico. Symposium: What’s New In Wound Healing. Off-label uses of tissue engineered skin. Kirsner RS. July 30, 1999 Summer American Academy of Dermatology. New York, New York. Symposium: Risk factors and risk assessment for vascular ulcers. Kirsner RS. October 3, 1999 Clinical Symposia for Wound Care, Denver, Colorado Symposium: Getting patients the appropriate care. Kirsner RS. November 12, 1999. Society for the Art and Science of Wound Management, Boca Raton, Florida Symposium: Malignancies and Wounds. Kirsner RS. November 13, 1999. Society for the Art and Science of Wound Management, Boca Raton, Florida Symposium: Medical treatment of venous ulcers. Kirsner RS. November 20, 1999. Oxford-Euroasian Wound Healing Meeting, Antalye, Turkey Symposium: The biology of skin grafts and the development of bioengineered skin. Medical treatment of venous ulcers. Kirsner RS. November 21, 1999. Oxford-Euroasian Wound Healing Meeting, Antalye, Turkey

Symposium: Update in Dermatology. Kirsner RS. January 17, 2000. PriMed, Ft. Lauderdale, FL. Symposium: Growth Factor and Tissue Engineered Skin. Kirsner RS. April 24, 2000. I Journados Argentinas de Inesteticismos Faciales y Corporales, Buenas Aires, Argentina Symposium: Venous Ulcers. Kirsner RS. April 24, 2000. I Journados Argentinas de Inesteticismos Faciales y Corporales, Buenas Aires, Argentina Symposium: Surgical Pearls. Kirsner RS. August 4, 2000. Summer American Academy of Dermatology, Nashville, TN. Symposium: What’s New In Wound Healing. Kirsner RS. August 4, 2000. Summer American Academy of Dermatology, Nashville, TN. Symposium: Tissue Engineered Skin. Kirsner RS. August 4, 2000. Summer American Academy of Dermatology, Nashville, TN. Symposium: Cellular Senescence in Venous Ulcers. Kirsner RS. September 11, 2000. Skin Forum V, Leeds, UK Symposium: Growth Stimulants for Wound Healing. Kirsner RS. September 13, 2000. Skin Forum V, Leeds, UK Symposium: Skin care and Pressure Ulcers. Kirsner RS. September 29, 2000. European Pressure Ulcer Advisory Panel, Pisa, Italy Symposium: Unusual Ulcers. Kirsner RS. October 8, 2000. Clinical Symposium on Wound Care, Nashville, TN. Symposium: Atypical Ulcers. Kirsner RS. September 20, 2001. Clinical Symposium on Wound Care, Orlando, FL Symposium: Growth Factors. Kirsner RS. September 20, 2001. Clinical Symposium on Wound Care, Orlando, Fl. Symposium: The biology of skin grafts and the development of bioengineered skin. Medical treatment of venous ulcers. Kirsner RS. January 20, 2001. Alabama Podiatric Association, Birmingham, Alabama Plenary Session: Tissue Engineering: Dermatology and Beyond. Kirsner RS. March 26, 2003. American Academy of Dermatology, San Francisco, CA Keynote Addess: Improving Refractory Wounds. Northeast Wound Ostomy and Continence Nursing meeting. April 5, 2003, Portsmouth, New Hampshire

Invited outside lectureships Elevated type II glucocorticoid receptor binding in keloids and hypertrophic scars.

Sawaya ME, Kirsner RS, Nemeth AJ, Weiss DS, Hsia SL, November 22, 1990, University of Miami (Research Seminar) Department of Dermatology, Miami, Fl.

Hypoxia induced stimulation of single fibroblast growth and its inhibition by suramin.

Kirsner RS, Katz MH, Falanga V; May 29, 1991, Miami Dermatologic Society, Miami, Fl. University of Miami (Research Seminar) Department of Dermatology June 04, 1991, Miami, Fl. Convatec Corp., February 05, 1992, Princeton, NJ.

Leg ulcers due to cyrofibrinogenemia: Rapid healing and pain relief with Stanozolol.

Kirsner, RS, Kerdel FA, Eaglstein WH, Katz MH, Falanga V. June 04, 1992, Miami Dermatologic Society, Miami, Fl.

Skin grafts as pharmacologic agents. Kirsner RS, Falanga V, Katz MH, Kerdel FA,

Eaglstein WH; February 05, 1992, Convatec Corp., Princenton, NJ, University of Miami (Research Seminar) Department of Dermatology, April 04,1992, Miami, Fl, Johnson & Johnson, Inc., November 05, 1992, Arlington, Tx. Graduate Course: Tissue Repair and Chronic Wounds, December 6, 1996, Miami, Fl. May 28, 1999, Wound Healing School Department of Dermatology, University of Miami School of Medicine, Miami, Fl. July 7, 1999,University of Miami Department of Dermatology (Resident Lecture Series), Miami, Fl.

Pulse steroid therapy: Revisited. Kirsner RS, Kerdel FA; June 03, 1993, Miami

Dermatologic Society, Miami, Fl. Managed Care: The dermatologist as a primary care provider or a specialist. Kirsner RS;

August 11, 1993, University of Miami (Research Seminar) Department of Dermatology, Miami, Fl, May 26, 1994, Miami Dermatologic Society, Miami, Fl (Resident's Day 3rd place Award). November 08, 1995, Broward County Dermatology Society Meeting, Ft. Lauderdale, Fl. Treatment with alpha-interferon associated with the development of paraneoplastic pemphigus. Kirsner, RS, Anhalt GH, Kerdel, FA; November 18, 1993, University of Miami (Research Seminar) Department of Dermatology, Miami, Fl.

Antiphospholipid Antibody Syndrome. Kirsner RS; September 10, 1993, University of

Miami Department of Dermatology (GEST Fellowship Lecture Series) Miami, Fl, October 07, 1994, University of Miami Department of Dermatology (Resident Lecture Series) Miami, Fl. August 06, 1997, University of Miami Department of Dermatology (Resident Lecture Series), Miami, Fl

The Wound Healing Process. Kirsner RS; March 24, 1994, University of Miami

Department of Surgery (Course for Surgical Residents) Miami, Fl. May 31,1996 University of Miami School of Nursing (Review course on wound healing), Miami, Fl. October 10, 1996 University of Miami Department of Dermatology (Resident Lecture Series) Miami, Fl. October 25, 1996, University of Miami Department of Urology, (Lecture Series) Miami, Fl. November 14, 1997 University of Miami Department of Dermatology (Resident Surgical Lecture Series) Miami, Fl. September 26, 1997. Mechanisms of Disease Course: Dermatology Section. University of Miami School of Medicine. Miami, Fl. January 15, 1998 Ortho-McNeil Wound Healing Preceptorship, Miami, Fl. January 29, 1998 Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. December 12, 1988 Wound Healing Course, Bon Secours Hospital, Port Charlotte, Fl. Office Management of Acne. Kirsner RS; July 16, 1994, University of Miami (Southern College Health Association Nursing Workshop) Miami, Fl, July 21, 1994, University of Miami Department of Dermatology (Resident Lecture Series) Miami, Fl. August 05, 1995 UM Care Lecture Series, Miami, Fl. August 11, 1995, University of Miami, Department of Dermatology (Resident Lecture Series) Miami, Fl. July 10, 1996 University of Miami, Department of Dermatology (Resident Lecture Series) Miami, Fl. September 17, 1997, University of Miami, Department of Dermatology (Resident Lecture Series) Miami, Fl. July 15, 1998, University of Miami, Department of Dermatology (Resident Lecture Series) Miami, Fl.

Pruritic Conditions in HIV. Kirsner RS; November 19, 1994, University of Miami

(Workshop - Dermatologic Manifestation of AIDS) Miami Beach, Fl, December 07, 1994, University of Miami, Department of Dermatology (Research Seminar) Miami, Fl.

Wound Care Management for Dermabrasion. Kirsner RS, January 20, 1995, University

of Miami (Research Seminar) Department of Dermatology, Miami, Fl. Internal Medicine Board Review: Dermatology: Kirsner RS, May 09, 1995,

Fundamental and Clinical Medicine, Miami, Fl, May 23, 1995 Ambulatory Care Lecture Series: University of Miami, Department of Medicine, Miami, Fl, August 03, 1995. Board Review: Internal Medicine, University of Miami, Department of Medicine, Miami, Fl. May 8, 1996 Board Review: Internal Medicine, University of Miami, Department of Medicine, Miami, July 23, 1996 Board Review: Internal Medicine, University of Miami, Miami, FL. May 9, 1997 Board Review: Internal Medicine, University of Miami, Miami, FL. May 9, 1998 Board Review: Internal Medicine, University of Miami, Miami, FL. May 1, 1999 Board Review: Internal Medicine University of Miami, Miami, FL. May 1, 2000 Board Review: Internal Medicine University of Miami, Miami, FL.

Lipodermatosclerosis. Kirsner RS, July 26, 1995, University of Miami (Research Seminar), Miami, Fl., May 29, 1996, University of Miami (Research Seminar), Miami, FL. Dermatophytes: Clinical and Mycologic Aspects. Kirsner RS. August 18, 1995.

University of Miami, Department of Dermatology (Resident Lecture Series).

Cutaneous manifestations of AIDS. Kirsner RS. October 07, 1995. The Grand Bahama Medical-Dental Association-Annual Conference, Freeport, Grand Bahamas.

Dermatopharmacology. Kirsner RS. November 03, 1995. Pharmacology Course for Sophomore Students. University of Miami School of Medicine, Miami, Fl. September 13, 1996. Pharmacology Course for Sophomore Students. University of Miami School of Medicine, Miami, Fl. April 24, 1998 Pharmacology Course for Sophomore Students. University of Miami School of Medicine, Miami, Fl., April 22, 1999 Pharmacology Course for Sophomore Students. University of Miami School of Medicine, Miami, Fl. May 10, 2000 Pharmacology Course for Sophomore Students. University of Miami School of Medicine, Miami, Fl.

Outcomes Study of Inpatient Dermatologic Therapy. Kirsner RS, March 20, 1996. Outcomes Research Group, Miami, Fl. Split Thickness Skin Grafting: Techniques, results, theory. Kirsner RS. December 06,1995. University of Miami (Research Seminar), Miami, Fl. Case Discussion: Cutaneous Tuberculosis. Kirsner RS April 15, 1996. Internal Medicine Club University of Miami School of Medicine, Miami, Fl. Inherited Blistering Diseases. Kirsner RS. April 16, 1996 Mechanisms of Disease Course: Dermatology Section, University of Miami, Miami, Fl. July 3, 1996 University of Miami Department of Dermatology (Research Seminar), Miami, FL. April 22, 1997 Mechanisms of Disease Course: Dermatology Section. Miami, Fl. September 26, 1997 Mechanisms of Disease Course: Dermatology Section. Miami, Fl. November 26, 1998 Mechanisms of Disease Course: Dermatology Section. Miami, Fl. November 28, 1999 Mechanisms of Disease Course: Dermatology Section. Miami, Fl. Clinical Skills in Dermatology. Kirsner RS. April 17, 1996 Clinical Skills Course. University of Miami, Miami, Fl. February 26, 1997, Clinical Skills Course, University of Miami, Miami, Fl. September 24, 1997, Clinical Skills Course University of Miami, Miami, Fl., November 18, 1998, Clinical Skills Course University of Miami, Miami, Fl., November 11, 1999, Clinical Skills Course University of Miami, Miami, Fl., Dermatology for the Generalist. Kirsner RS, June 16, 1996, The William A. Little Obstetrical and Gynecological Society Annual Meeting, Key Biscayne, Fl. May 12, 1997 Primary Care Clerkship 3rd Year Medical Students University of Miami School of Medicine, Miami, Fl. April 27, 1999, Symposium for Advanced Wound Care/Medicial Research Forum, Anaheim, CA.

Overview of Psoriasis. Kirsner RS, November 16,1996, Psoriasis for the Generalist, Miami, Fl.. September 25, 1997. Mechanisms of Disease Course: Dermatology Section. University of Miami School of Medicine. Miami, Fl. January 23, 1998, Pri-Med Course, Ft. Lauderdale, Fl. Health Care Delivery: Patient Access and Quality of Care. Kirsner RS, February 4, 1997, Epidemiology Research Seminar, Department of Epidemiology & Public Health, Miami, Fl., February 12, 1997 University of Miami Department of Dermatology (Research Seminar), Miami, FL., November 12, 1998 St. Louis University Department of Dermatology Grand Rounds, St. Louis, MO. What’s New In The Treatment of Cutaneous Ulcers. Kirsner RS. May 17, 1997. North Broward Hospital District, Ft. Lauderdale, FL. Toxic Epidermal Necrolysis. Kirsner RS. September 12, 1997. University of Miami Department of Internal Medicine Morbidity and Mortality Conference, Miami, Fl. Soaps and Detergents: A Clinicians’ Guide. Kirsner RS. September 13, 1997. Third Annual Round Table Discussion. Convatec Corporation. Short Hills, NJ

Venous Disease: Pathogenesis and Therapy. Kirsner RS. January 15, 1998. Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. January 29, 1998 Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. October 29, 1998, Ortho-McNeill Wound Healing Preceptorship. Miami, Fl, November 5, 1998 Centers of Wound Healing Excellence Meeting, Miami, Fl. . December 12, 1988 Wound Healing Course, Bon Secours Hospital, Port Charlotte, Fl. May 24, 1999, Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. May 13, 1999, Wound Healing School Department of Dermatology, University of Miami School of Medicine, Miami, Fl., Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. July 15, 1999, Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. August 12, 1999

Skin Cancer Prevention: The role of generalists. Kirsner RS. January 21, 1998, University of Miami Department of Dermatoogy (Research Seminar) Miami, Fl., April 7, 1998 University of Miami Department of Epidemiology and Public Health (Research Seminar). Dermatitis Medicamentosa. Kirsner RS. January 23, 1998. Pri-Med Course, Ft. Lauderdale, Fl.

When Biopsying A Wound Is Important. Kirsner RS. April 21, 1998. Symposium for Advanced Wound Care/ Medical Research Forum, Miami Beach, Fl. . December 12, 1988 Wound Healing Course, Bon Secours Hospital, Port Charlotte, Fl.

What’s New In Wound Healing. Kirsner RS. August 18, 1998. Memphis Dermatological

Society, Memphis, TN. October 17, 1998 Challenges in the management of long term patients, Weston, FL. October 29, 1998 Advanced Technologies in Wound Healing. Miami Beach, FL. November 11, 1998 St. Louis University Department of Dermatology, St. Louis, MO. November 23, 1998 Institute for Retired Professionals, Miami, FL.

Evolving therapies in the treatment of venous leg ulcers. Kirsner RS. September 17, 1998. State University of New York at Stony Brook, Stony Brook, New York.

Growth Factor Therapy. Kirsner RS. November 5, 1998. Centers of Wound Healing

Excellence Meeting, Miami, Fl. . December 12, 1988 Wound Healing Course, Bon Secours Hospital, Port Charlotte, Fl. May 17, 1999 East Elmhurst, New York, May 18, 1999 Garden City, New York. May 24, 1999, Wound Healing School Department of Dermatology, University of Miami School of Medicine, Miami, Fl. Non-melanoma skin cancer. Kirsner RS. November 24, 1998. Mechanisms of Disease Course. Dermatology Section, Miami, Fl.

Update on Melanoma: Pathogenesis, Detection and Prevention. Kirsner RS. December 3, 1998. Ninth Update on Cancer for the General Cancer Practitioner, Miami, Fl. Managed Care vs. Fee For Service: Stage at Diagnosis and Survival for Melanoma Kirsner RS, February 17, 1999. Epidemiology Research Seminar, Department of Epidemiology & Public Health, Miami, Fl. Tissue Engineering. Kirsner RS, April 21, 1999, Nashville, Tenn. Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. July 16, 1999, Ortho-McNeill Wound Healing Preceptorship. Miami, Fl. August 13, 1999

The use of adjuvant steroids for the treatment of skin and soft tissue infections. Kirsner RS, April 27, 1999. Symposium for Advanced Wound Care/Medical Research Forum, Anaheim, CA. May 28, 1999, Wound Healing School Department of Dermatology, University of Miami School of Medicine, Miami, Fl. July 7, 1999 University of Miami (Research Seminar) Department of Dermatology, Miami, Fl.

VI. CURRENT AND PAST TEACHING RESPONSIBILITIES 07/94 - 6/96 Coordinator - Dermatology Education UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 07/94 - Present Director - Mechanisms of Disease Course, Dermatology Section UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

Member - Curriculum Committee UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

11/95- Present Lecturer - Pharmacology Course UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

04/95- Present Lecturer - Clinical Skills Course

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

04/95- Present Lecturer - Mechanisms of Disease Course UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

08/96- 08/99 Co-Coordinator- Graduate Course in Tissue Repair and Chronic Wounds

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

05/97- 05/98 Lecturer - Primary Care Clerkship UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 05/99 – 6/01 Director - Wound Healing School Department of Dermatology & Cutaneous Surgery UNIVERSITY OF MIAMI SCHOOL OF MEDICINE THESIS AND DISSERTATION ADVISING

07-99 – 4/01 Mary Beth Regan Doctoral Candidate UM School of Nursing

VII. SERVICE DEPARTMENTAL ADMINISTRATIVE AND COMMITTEE RESPONSIBILITIES

07/95 - Present Co-Director - G.E.S.T. Fellowship Program DEPARTMENT OF DERMATOLOGY AND CUTANEOUS SURGERY UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

02/97 - 5/98 Co-Director- Wound C.U.R.E. Center

UNIVERSITY OF MIAMI/COLUMBIA-CEDARS MEDICAL CENTER

06/98 - Present Director- Wound C.U.R.E. Center

UNIVERSITY OF MIAMI/COLUMBIA-CEDARS MEDICAL CENTER

10/97 – 10/99 Member - PhD-MPH Curriculum Committee

DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

04/98 – 9/00 Member - Resident Research Committee DEPARTMENT OF DERMATOLOGY AND CUTANEOUS SURGERY UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

04/98 - Present Chair- Research Policy Task Force DEPARTMENT OF DERMATOLOGY AND CUTANEOUS SURGERY UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

EXTRA-DEPARTMENTAL ADMINISTRATIVE AND COMMITTEE RESPONSIBILITIES

06/97 - 12/97 Member - Utilization Review Committee COLUMBIA-CEDARS MEDICAL CENTER

01/98 – 12/00 Member - Credentials Committee COLUMBIA-CEDARS MEDICAL CENTER

12/98 – 12/00 Member, Institutional Review Board, Professional Misconduct Committee

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 9/00 – Present Melanoma Tumor Board UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 2/01 – 4/02 LCME Medical Education Task Force UNIVERSITY OF MIAMI SCHOOL OF MEDICINE COMMUNITY SERVICE 10/93 - Present Camillus House Health Concern Bi-weekly dermatology clinic

02/94 - 02/98 Florida Keys Health Fair 05/94 - Present Melanoma/Skin Cancer Screening Program 09/96 National Psoriasis Foundation Lecturer 11/96 Miami Transplant Society Lecturer 12/01 Advisor – Skin Care Curriculum –Miami-Dade County School

Board

*****

CURRICULUM VITAE

PERSONAL Name Peter Sheehan Office Address Diabetes Foot & Ankle Center

Hospital for Joint Diseases 301 East 17th Street New York, NY 10003 Tel: (212) 598-2378 Home Address 455 East 72nd Street Apartment 24E New York, NY 10021 Date of Birth May 6, 1954 E-Mail Peter.Sheehan@msnyuhealth.org EDUCATION 1981 MD SUNY Downstate Medical Center, School of Medicine Brooklyn, NY CLINICAL TRAINING 1981 – 1984 Staten Island Hospital, Staten Island, NY Completed internship and two-year residency in Internal Medicine at a major affiliate of SUNY-Downstate Under the direction of Thomas G. McGinn, M.D. Chief of Medicine 1984 – 1986 Yale University School of Medicine, New Haven, CT Fellow in the Department of Endocrinology and Metabolism with clinical responsibilities at the Yale- New Haven Hospital and West Haven Veterans Administration Hospital under the direction of Howard Rasmussen, M.D., Ph.D., Section Chairman. RESEARCH EXPERIENCE 1976 University of Illinois School of Medicine, Department

of Biochemistry, Chicago. Involved in the study and synthesis of phosphonates under the supervision of Thomas O. Henderson, Ph.D 1977 John Hopkins University School of Medicine, Department of Psychopharmacology, Baltimore In laboratory of Lasker Award recipient, Solomon H. Snyder, M.D., studied distribution and binding Characteristics of CNS alpha adrenergic receptors. 1984 – 1986 Yale University School of Medicine, Department of Endocrinology and Metabolism, New Haven Involved in research fuel metabolism and diabetes

Mellitus under the supervision of Ralph A. DeFronzo, M.D. 1990 – 2000 Staten Island University Hospital, Department of Internal Medicine. Developed and participated in Various clinical studies, primarily in diabetes mellitus and

Its related foot and skin disorders, including research trials For Merck, Scios, CalBio, ConvaTec, Alpha Therapeutics, Organogenesis, Advanced Tissue Sciences, and Johnson & Johnson

2000 – Present Hospital for Joint Diseases

Several clinical trials in wound healing, vascular medicine, Diabetic neuropathy, and foot infections

BOARD CERTIFICATIONS 1984 American Board of Internal Medicine 1987 American Board of Internal Medicine, Subspecialty Board of Endocrinology and Metabolism 1990 American Board of Internal Medicine, Subspecialty Board of Geriatric Medicine ACADEMIC APPOINTMENTS 1986 - 2002 SUNY Health Science Center, Brooklyn, NY Assistant Clinical Professor of Medicine 2002 – Present New York University School of Medicine,New York, NY Associate Professor of Medicine, Clinical

HOSPITAL APPOINTMENTS 2000 Hospital for Joint Diseases, New York, NY Director, Diabetes Foot & Ankle Center 1990 – 2000 Staten Island University Hospital, Staten Island, NY Director, Diabetes Treatment Center 1986 – 2000 Staten Island University Hospital, Staten Island, NY Attending Physician, Medical Staff PROFESSIONAL APPOINTMENTS 1986 – 1996 Staten Island Diabetes and Endocrinology Associates Endocrinologist, Private Practice 1997 – 1999 American Diabetes Association Foot Council Delegate to Scientific Sessions Committee 1997 – 2000 American Diabetes Association Official Liasion to the American Podiatric Medical Association 2001 - 2003 American Diabetes Association

Chair, Council for Foot Care 2000 - Present Visiting Nurse Service of Greater New York,

Medical Advisory Board 1985 – Present Member, American Diabetes Association 1999 – Present Editorial Board, Wounds 2003 – Present Member, “Make the Link” Committee American Diabetes Association 2003 – Present Member, American Heart Association 2003 – Present Member, Wound Healing Society 2003 – Present Fellow, Society for Vascular Medicine and Biology

CLINICAL TRIALS 2004 A Prospective Randomized Clinical Trial Evaluating

PANAFIL Spray and REGRANEX Gel 0.01% in Patients with Diabetic Foot Ulcers

2003 - 2003 ConvaTec, Principal Investigator, A Phase IV study of

Aquacel AG Dressing versus Saline-Moistened Gauze in the Management of Diabetic Foot Ulcers

2003 Nissan Chemical Industries, Principal Investigator, A

Double-Blind, Randomized, Parallel Group, Placebo-Controlled Study to Evaluate the Safety and Efficacy of NM-702 in Subjects with Intermittent Claudication

2003 Aggenix, Inc., Principal Investigator, A Phase 1/2 study of

Safety and Efficacy of Topical Administration of Recombinant Human Lactoferrin in patients with Diabetic Neuropathic Foot Ulcers

2003 King Pharmaceuticals, Principal Investigator, A Double-

Blind, Randomized, Vehicle-Controlled, Sequential-Dose-Escalation Study Assessing the Safety, Clinical Pharmacology, Systemic Disposition, and Pharmacokinetics of MRE0094 Gel Versus Matching Vehicle Gel When Applied Topically to Subjects with Diabetic, Neuropathic, Foot Ulcers.

2002 - 2003 Merck, Principal Investigator, A prospective, Multicenter,

Double-Blind with In-House Blinding, Randomized, Comparative Study to Evaluate the Efficacy, Safety, and Tolerabiltiy, of Ertapenem Versus piperacillin/Tazobactam in the Treatment of Diabetic Foot Infections in Adults

2001 - 2002 Wyeth, Principal Investigator. An Open Label

Randomized Study Comparing the Efficiency and Safety of Piperacillin/Tazobactam and Ampicillin/Sulbactam administered Intravenously in the Empirical Treatment of Foot Infections in Diabetic Patients.

2001 - 2002 ConvaTec, Principal Investigator. A Prospective, Randomized, Comparative Parallel Study of Hyalofill Wound Dressing in the Management of Indolent Diabetic Foot Ulcers.

2001 - 2002 Bayer, Principal Investigator. A Prospective, Randomized Double-Blind, Multicenter Trial Assessing the Safety and Efficacy of Sequential (Intravenous/Oral) BAY 12-81039(Moxifloxacin) 400mg every 24hr Compared to Intravenous Piperacillin/Tazobactam 30./0.375g every 6hr Followed by Oral Amoxicillin/Clavulanic Acid suspension 800mg every

12hr for the Treatment of Patients with Complicated Skin and Skin Structure Infections. 2001 Welfide, Principal Investigator. A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy and Safety of Critical Leg Ischemia 2001 - 2003 Welfide, Principal Investigator. A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy and Safety of Circulase in Conjunction

with Peripheral Revascularization for the Treatment of Critical Leg Ischemia

2001 - 2002 Organogenesis, Principal Investigator. A Non-Masked Multi-Center Prospective Clinical Trial of Vitrix and Standard Care of the Treatment of Deep Diabetic Foot Ulcers 2001 - 2002 Novartis, Principal Investigator. A Prospective, Multi- Center, Open-Label Study to Evaluate the Safety and

Efficacy of Apligraf in the Treatment of Diabetic (Primarily Neuropathic) Foot Ulcers that have not adequately Responded to Standard Therapy

2001 - 2002 Otsuka, Principal Investigator. A Randomized, Double-

Blind, Placebo-Controlled, Multicenter, Parallel-Arm Study To Assess the Long-Term Effects of Pletal (Cilostazol) Versus Placebo Administered Orally to Patients with Intermittent Claudication Secondary to Peripheral Arterial Disease.

2001 - 2003 Sigma Tau, Principal Investigator. Safety and Efficacy of Propionyl-L- Carnitine in Peripheral Arterial Diseases (Intermittent Claudication) as Assessed by a Fixed Treadmill Protocol in a Diabetic Population 2001 - 2002 Bristol Myers, Principal Investigator. A Randomized, Double-Blind, Multi-Center, Comparative Phase III Study

Of Intravenous BMS-284756 with or without oral BMS- 284756 follow-up versus Intravenous Piperacillin/ Tazobactam with or without oral Amoxicillin/Clavulanate Follow-up in the Treatment of Complicated Skin and Skin Structure Infections 2001 - 2002 ConvaTec, Principal Investigator. A Phase III, Prospective

Randomized, Stratified, Comparative Study of Next Generation Cover Dressing versus Two Competitive

Foam Dressings in the Management of Venous Leg Ulcers 2001 - 2003 Pfizer, Principal Investigator. A 15 Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi- Center Study of Neurontin (gabapentin) for Efficacy and

Quality of Life in Subjects with Painful Diabetic Peripheral Neuropahty

1999 – 2000 Principal Investigator LY333328 VS. Vancomycin in Skin/Skin Structure Infections 1999 – 2000 Principal Investigator A Prospecitve, Multi-Center, Randomized, Single-Masked, Controlled, Clinical Investigation of Dermagraft In Patients with Plantar Diabetic Foot Ulcers 1999 – 2000 Principal Investigator A Multi-Center Prospective, Randomized, Controlled Clinical Trial of Graftskin for The Treatment of Diabetic Foot Ulcers PUBLICATIONS ABSTRACTS 1. U’Prichard, DC, Greenberg, DA, Sheehan, P, and Synder, SH. Regional distribution of noradrenergic receptor binding in calf brain, Brain Research, 1978, 138: 151-158. 2. Greenberg, DA, U’Prichard, DC, Sheehan, P, and Solomon, SH: A-noradrenergic receptors in the brain: differential effects of sodium on binding of (H) agonists and (h) antagonists, Brain Research, 140(1978),378-384. 3. Greenberg, DA, U’Prichard, DC, Sheehan, P, and Snyder, SH. Tricyclic antidepressants: Therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain, Science, 199:197 – 198, January 13, 1978.

4. Sheehan, P., Iannuzzi, LN, Hoffman, RS. The charcot foot and microvascular disease: a clinical association (abstract #785), Diabetes, 1990; 39 Supp 1, 199A. 5. Hausner, L, Sheehan, P, Simpkins, H. Pnacreatic pathology in pentamidine-induced diabetes in acquired immunodeficiency syndrome patients, Human Pathology, 1991, 926-9. 6. Sheehan, P, Rothman, JG, Ferdinando, EJ, Iannuzzi, LN. Medical Management of osteomyelitis in the diabetic foot Diabetes, June 1992, 41 Supp A, 85A. 7. Del Prato, S, Leonetti, F, Simonson, DC, Sheehan, P, Matsuda, M, DeFronzo,RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin Secretion and insulin sensitivity in man, Diabetologia. 37(10): 1025-35, 1994 Oct. 8. Sheehan, P, Ferdinando, EJ. Use of ceretec scan in the diagnosis of osteomyelitis in the diabetic foot, Diabetes, 44, Suppl 1, May 1995. 9. Sheehan, P, Vishaiv, A, Brodsky, J, Ahearn, K. Clinical and economic impact of a foot program on inpatient outcomes, Diabetes, 46, Suppl 1, May 1997. 10. DelPrato, S, Matsuda, M, Simonson, DC, Groop, LC, Sheehan, P, Leonetti, F, Bonadonna, RC, DeFronzo, RA. Studies on the mass action effect of glucose Resistance, Diabetologia (1997) 40:687-697. 11. Iannuzzi, N, Sheehan, P. Total – Contact casting and lower extremity ulcers, Podiatry Today, 26, November 1999, Vol 12, No. 6. 12. Mckay DJ, Sheehan P, Delauro TM, Iannuzzi LN. Vincristine-induced neuroarthropathy (Charcot’s joint), J Am Podiatr Med Assoc 2000 Oct;90 13. Sheehan P. Presentation of Consensus Development Conference on Diabetic Foot Wound Care, Wounds 2001; 13(5 Suppl E):6E-8E 14. Yadlapalli NG, Vaishnav A, Sheehan P. Conservative Management of Diabetic Foot Ulcers Complicated by Ostoemyelitis, Wounds 2002; 14(1):31-35 15. Veves A, Sheehan P, Pham H. Promogran for the treatment of foot ulcers, Archives of Surgery, 2002, In Press 16. Sheehan P. Principles of Care in the Surgical Patient with Diabetes, The Diabetic Foot: Medical and Surgical Management, 2002, 1-34 LECTURES AND SEMINARS 2004 Wound Healing Society “Diabetic Foot Infections”

Atlanta, Georgia 2004 Society for Vascular Medicine & Biology

Therapeutic changes of the Diabetic Foot Anaheim, California

2004 American Diabetes Association

Pharmacotherapy of Peripheral Arterial Disease Orlando, Florida

2004 Peripheral Arterial Disease in People with Diabetes

Atlantic City, NJ 2004 Peripheral Arterial Disease in People with Diabetes

San Juan, Puerto Rico 2003 Prairie Vascular Summit 2003

St. Louis 2003 2003 Symposium on Advanced Wound Care & Medical

Research Forum Las Vegas, NV

2003 Wound Ostomy and Continence Nurses Society

Cincinnati Convention Center, Cincinnati, Ohio 2003 2003 Board of Directors & National Committee Meeting

American Diabetes Association Annual Meeting, McLean,VA

2003 Wound Care Conference Montefiore Medical Center, Bronx, NY

2003 Healing the Diabetic Foot Wound: A Marriage of

Traditional and New Technologies 2003 New York Podiatric Clinical Conference, New York, NY

2002 Wound Healing: Science & Industry Hospital for Joint Diseases

St. Thomas U.S.- Virgin Islands

2002 The Diabetic Foot Update 2002 San Antonio, Texas

1992 – 1995 Pedorthic Management of the Diabetic Foot Annual course, Prescription Footware Association, Wagner College, Staten Island, NY 1993 Overview of Diabetic Foot Compliations Vivra Annual Meeting, Nashville, TN 1994 Symposium on the Diabetic Foot Hospital for Joint Diseases 1994 Seminar on Diabetic Foot Westwood Pharmaceuticals, San Francisco 1994 Management of the Diabetic Foot East Orange VA, East Orange, NJ CONSULTANT

Bristol Myers Squibb, Sanofi/Synthelabo, Greystone Medical, Pfizer, Inc.

SPEAKER’S BUREAU

Bristol Myers Squibb, Otsuka Pharmaceutical, Pfizer, Inc., Merck