Name: Gholamreza Karimi

Date and place birth: 1968, Tehran, Iran

Nationality: Iranian

Material status: Married (two daughter)

Education:

Pharm.D: 1992: School of Pharmacy, Mashhad, Iran

Ph. D: 1999: Dep of Pharmacology and Toxicology, School of Pharmacy, Tehran, Iran

Assistant Professor: 2000-2004 (Mashhad University of Medical Sciences)

Associate Professor: 2004-2008 (Mashhad University of Medical Sciences)

Professor 2009: up to now (Mashhad University of Medical Sciences)

Fellowship: Montreal Heart Institute (Canada) 2013:

The role of MicroRNA in oxidative stress of heart

Positions:

Head of pharmacology and toxicology, Dep, 2000-2002

Manager of pharmacology Lab, 2000 up to now

Manager of Mashhad drug and poison information center, 2000 up to 2012

Deputy food and drug organization in Mashhad University 2005 up to 2012

Teaching Experiences

Cardiovascular Pharmacology (Pharm D, PhD students)

Cardiovascular Toxicology (Pharm D students)

CNS Toxicology (Pharm D students)

Drug Information and Pharmacy Practice (Pharm D students)

Natural Toxins (MSc. students)

Pharmacology of Vasoactive Peptide (Ph.D. students)

Organ ( heart, liver, kidney) Toxicity (Ph.D. students)

Forensic Toxicology (Ph.D. students)

Drug and poison information resources (Ph.D student)

Books

Drugs and Herbs Interaction 2005

Natural toxin ( farsi edition), MUMS, 2012

Natural toxin ( 2 chapter , English), springer, 2014

Encyclopedia of toxicology ( 6 monograph, English), Elsevier, 2014

Some Publication

1. Determination of methanol in Iranian herbal distillates

Kobra Shirani, Faezeh Vahdati Hassani, Kamal Razavi Azar-Khiavi, Zohreh Samie Moghaddam

and Gholamreza Karimi*. J Complement Integr Med. 2016; aop

2. Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line.

Shadi Mahdizadeh, Gholamreza Karimi, Javad Behravan, Sepideh Arabzadeh, Hermann Lage

and Fatemeh Kalalinia.

Mahdizadeh et al. DARU Journal of Pharmaceutical Sciences (2016) 24:17

3. Immunotoxicity induced in mice by subacute exposure to berberine.

Mahmoudi M, Zamani Taghizadeh Rabe S, Balali-Mood M, Karimi G, Memar B, Rahnama M,

Tabasi N, Khazaee M, Riahi-Zanjani B.

J Immunotoxicol. Volume 13, Issue 2, 3 March 2016, Pages 255-262. (IF:1.22)

4. Arsenic cardiotoxicity :An overview,

Nafiseh Sadat Alamolhodaei a ,Kobra Shirani b ,Gholamreza Karimi c,∗

Environmental Toxicology and Pharmacology 40(2015)1005–1014

5. Evaluation of anti-cancer and immunomodulatory effects of carnosol in a Balb/c WEHI-164

fibrosarcoma model

Maryam Rahnama, Mahmoud Mahmoudi, Shahrzad Zamani Taghizadeh Rabe, Mahdi Balali-

Mood, Gholamreza Karimi, Nafiseh Tabasi, and Bamdad Riahi-Zanjani

J Immunotoxicol, Volume 12, Issue 3, 1 July 2015, Pages 231-238

6. Use of Carnosol as a Highly Immunosuppressive Agent.

Mahmoud Mahmoudi; Shahrzad Zamani Taghizadeh Rabe; Maryam Rahnama ; Mahdi Balali

Mood; Gholamreza Karimi ; Bamdad Riahi-Zanjani ,*.

Jundishapur J Nat Pharm Prod.

2015 August; 10(3): e20824. Pubmed

7. Safranal as a safe compound to mice immune system.

Bamdad Riahi-Zanjani, Mahdi Balali-Mood, Elaheh Mohammadi, Hassan Badie-Bostan, Bahram

Memar, Gholamreza Karimi*.

AJP, Vol. 5, No. 5, Sep-Oct 2015

8. Maternal Exposure to Silymarin Leads to Phatological Changes in mouse Foetuses.

Gholami, M. ; Moallem, S.A.; Afshar, M. ; Etemad, L. * ; Karimi, G.

Pharmacology online, Aug. 2015 • vol.2 •

9. Effects of silymarin on neuropathic pain and formalin‐ inducednociceptionin mice.

FaezehVahdatiHassani , RaminRezaee ,HasanSazegara ,MahmoudHashemzaei ,Kobra Shirani

, GholamrezaKarimi *.

Iran J Basic Med Sci, Vol. 18, No. 7, Jul 2015

10. Effect of gold nanoparticles on postoperative peritoneal adhesions in rats.

Amir Hooshang Mohammadpour, Alireza Tavassoli, Mohammad Reza Khakzad, Elahe

Zibaee, Mohammad ,AfsharMahmoud Hashemzaei , Gholamreza Karimi* .

Nanomed J, Vol. 2, No. 3, Summer 2015

11. Phytotrapy of cyclophosphamide-induced immunosuppression.

Kobra Shirani ,Faezeh Vahdati Hassani ,Kamal Razavi-Azarkhiavi ,Somayeh Heidari ,Bamdad

Riahi Zanjani ,Gholamreza Karimi

Enviromental toxicology and pharmacology . 2015 May;39(3):1262-1275

12. Ursolic acid induced apoptotic cell death following activation of caspases in isolated

human melanoma cells.

Mahmoud Mahmoudi, Shahrzad Zamani Taghizadeh Rabe, Mahdi Balali-Mood, Gholamreza

Karimi, ,Nafiseh Tabasi and Bamdad Riahi-Zanjani*

Cell Biol Int,39(2015) 230–236.

13. Efficacy of orally administered montmorillonite for acute iron poisoning detoxification in

rat.

Parisa Mirhoseini Moosavi, Ali Reza Astaraei ,Alireza Karimi, Mohammad Moshiri, Leila Etemad,

Majid Zeinalid, Gholamreza Karimi

Applied Clay Science 103 (2015) 62–66.

14. Crocin Effects on Human Myeloma Cells Regarding Intracellular Redox State, DNA

Fragmentation, and Apoptosis or Necrosis Profile.

Ramin Rezaee, Khadijeh Jamialahmadi , Bamdad Riahi Zanjani, Mahmoud Mahmoudi

Jundishapur J Nat Pharm Prod. 2014 November; 9(4).

15. Serum cytokine profiles of Khorasan veterans 23 years after sulfur mustard exposure.

Bamdad Riahi-Zanjani, Mahdi Balali-Mood, Seyed-Reza Mousavi, Gholamreza Karimi, Mahmood

Sadeghia, Elham Shirmast, Mahmoud Mahmoudi.

Cytokine. 2014 Dec;70(2):161-4.

16. Preparation and Evaluation of Histamine Imprinted Polymer as a Selective Sorbent in

Molecularly Imprinted Solid-Phase Extraction Coupled with High Performance Liquid

Chromatography Analysis in Canned Fish.

A Sahebnasagh , Karimi, G*, SA Mohajeri .

Food Anal. Methods. (2014) 7:1–8.

17. A survey of aflatoxins in sesame seeds imported into Khorasan Province, Iran.

Ali Reza Hosseininia , Maryam Vahabzadeh , Marziyeh Rashedinia , Bamdad Riahi-Zanjani,

Karimi, G* .

Mycotoxin Res .2014 Feb;30(1):43-6..

18. Protective effects of glucosamine hydrochlorideagainst free radical-induced erythrocytes

damage. Damage.

Khadijeh Jamialahmadia,b, Omid Arastehc, Maryam Matbou Riahib,Soghra Mehrid, Bamdad

Riahi-Zanjanie, Karimi, G*.

Environmental toxicology and pharmacology 38 ( 2014 ) 212–219

19. Comparative Studies of Cytotoxic and Apoptotic Properties of Different Extracts and the

Essential Oil of Lavandula angustifolia on Malignant and Normal Cells.

Z Tayarani-Najaran , A Amiri , Karimi, G, SA Emami , J Asili, S H Mousavi.

Nutrition and Cancer,

2014 Apr;66(3):424-34

20. Cytotoxic and Apoptotic Potential of Rheum turkestanicum Janisch Root Extract on

Human Cancer and Normal Cells.

Shiezadeh F, Mousavi SH, Sadegh Amiri M, ranshahi M, Tayarani-Najaran Z and Karimi, G*.

Iranian journal of pharmaceutical science .

2013: 12( 4), Autumn 2013, 811-819

21. Evaluation of anticonvulsant effect of two novels 4-[1-(4-fluorobenzyl)-5-imidazolyl]

dihydropyridine derivatives in mice.

Hadizadeh F., Rahimi B., Taghiabadi E. , Razavi M., Karimi G*.

Research in Pharmaceutical Sciences, May 2013; 8(2): 91-95

22. Evaluation of in vitro toxicity of peptide 3 (N-acetyl-Leu-Gly-Leu-COOH)-substituted-β- 4

cyclodextrin derivative, a novel drug carrier, in 5 PC-12 cells. Sadeghnia et al.

Hamid Reza Sadeghnia, Faezeh Vahdati Hassani, Hamid Sadeghian, Maryam Miandehi, Farzin

Hadizadeh and Karimi, G*

DARU Journal of Pharmaceutical Sciences 2013, 21:75

23. Preparation and Evaluation of Histamine Imprinted Polymer as a Selective Sorbent in

Molecularly Imprinted Solid-Phase Extraction Coupled with High Performance Liquid

Chromatography Analysis in Canned Fish.

Sahebnasagh, A., Karimi, G. , Mohajeri, S.

Food Analytical Methods , March 2013, Pages 1-8

24. Cytotoxic effects of crocin on MOLT-4 human leukemia cells.

Ramin Rezaee, Mahmoud Mahmoudi, Khalil Abnous, Shahrzad Zamani, Taghizadeh Rabe,

Nafiseh Tabasi, Mahmoud Hashemzaei and Karimi, G *.

J Complement Integr Med. 2013; 10(1): 1–8

25. Protective Effect of Silymarin against Acrolein-InducedCardiotoxicity in Mice.

Taghiabadi E, M Imenshahidi, Kh Abnous, F Mosafa, M Sankian,B Memar,6 and Karimi G*.

Evidence-Based Complementary and Alternative Medicine. 2012;2012:352091.

26. Tracheal responsiveness to methacholine and ovalbumin; and lung inflammation in guinea

pigs exposed to inhaled lead after sensitization.

HosseinBoskabady M , karimi G , Samarghandian S , Farkhondeh T.

Ecotoxicology and Environmental Safety ,2012, 86 : 233–238

27. Comparison of Intralesional Two Percent Zinc Sulfate and Glucantime Injection in

Treatment of Acute Cutaneous Leishmaniasis.

Maleki M, Karimi G, Tafaghodi M, Raftari S, Nahidi Y.

Indian Journal of Dermatology, 2012, 57;118-122.

28. Evaluation of nitric oxide or opioid receptors involvement in antinociceptive properties of

silymarin1.

Imenshahidi M 1, Rezaee R 2, MostofI A , Karimi G *.

AJP, 2012 , 2:39-45

29. Determination of heavy metals in different honey brands from Iranian market,

Akbari B , Gharanfoli F , Hassanzadeh Khayyat M, Khashyarmanesh Z, Rezaee R , Karimi G*.

Food Additives and Contaminants ,2012 , 5: 1-7.

30. Determination of parathion, aldicarb and thiobencarb in tap water and bottled mineral

water in Mashhad , Iran.

Rezaee R, Hassanzadeh-Khayyat M, Khashyarmanesh Z, Moallemzadeh Z, Mehri F, Karimi G*.

Drug and Chemical Toxicology, 2012, 35:1-7.

31. Determination of parathion, aldicarb and thiobencarb in tap water and bottled mineral

water in northeast of Iran

R. Rezaee, M. Hassanzadeh-Khayyat, Z. Khashyarmanesh, H. Moallemzadeh, F. Mehri, Karimi

G*

Drug Chem Toxicol, 2012 Apr;35(2):192-8

32. Clozapine recognition via molecularly imprinted polymer, bulk polymerization versus

precipitation method

Mohajeri A, Karimi G, Aghamohammadian J, Rajabnia M

J Applied Polymer Scie, 2011, 121: 3590-3595

33. Silymarinm a promising pharmacological agent for treatment of disease

Karimi G, M Vahabzadeh, P Lari, M Rashedinia, M Moshiri

IJBMS, 2011,14:308-317

34. Benefit of nanocarrier of magnetic magnesium in rat malathion-induced toxicity and

cardiac failure using non-invasive monitoring of electrocardiogram and blood pressure.

Mohammadi H, Karimi G, Rezayat SM, Dehpour AR, Shafiee H, Nikfar S, Baeeri M, Sabzevari

O, Abdollahi M.

Toxicol Ind Health. 2011, 27:417-429

35. Protective effect of aqueous and ethanolic extract of saffron stigma and petal on liver

toxicity in duced by carbon tetrachloride in mice.

M Iranshahi, M Khoshangosht, Z Mohammadkhani, Karimi G*

Pharmacologyonline , 2011,1: 203-212

36. Curcumin potentiates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells

through generation of reactive oxygen species

L Hosseinzadeh, J Behravan, F Mosaffa, Gh Bahrami, A Bahrami and Karimi G*

Food and Chemical Toxicology. 2011, 49: 1102-1109

37. Evaluation of suppressive effect of paraquat on innate immunity in Balb\c mice.

Riahi, B., Rafatpanah, H., Mahmoudi, M., Memar, B., Brook, A., Tabasi, N., Karimi G.*

J Immunotoxicology, 2011, 8:39-45

38. Effect of curcumin on doxorubicin induced cytotoxicity in H9C2 cardiomyocyte cells.

Hosseinzadeh L, Behravan J, Mosaffa F, Karimi G.*

IJBMS, 2011, 14:49-56

39. Clozapine imprinted polymers: synthesis, ccharacterization and application for drug assay

In human serum.

Mohajeri A, karimi G, Rajabnia m.

Analytica Chimica Acta, 2010, 683: 143-148

40. Antinociceptive effect of Elaeagnus angustifolia fruits on sciatic nerve ligated mice.

Karimi G*, Hosseinzadeh h, Rassoulzadeh M, Razavi M, Taghiabadi E.

IJBMS, 2010, 13: 97-101

41. Effects of Silymarin administration on TNF-α Serum concentration in peritoneal dialysis

patients

Nazemian F, Karimi G. Moatamedi M, Charkazi S, Shamsara J, Mohamadpoor A Phytotherapy Res, 2010, 24:1654-1657

42. Screening of acetylcholinesterase inhibitory activity of terpenoid and coumarin

derivatives from the gens ferula

Karimi G*, Iranshahi M, Hosseinzadeh F, Riahi B, Sahebkar A

Pharmacologyonline, 2010, 1: 566-574

43. Protective Effects of Aqueous and Ethanolic Extracts of Portulaca oleraceae against

cisplatin induced nephrotoxicity

Karimi G*, Khoei A, Omidi A, Kalantari M, Babaei J, Taghiabadi E, Razavi M

IJBMS, 2010, 13: 31-35.

44. Evaluation of silymarin effect on granulose cell apoptosis and follicular development

inpatients in patients undergoing IVF

Moosavifar N, Mohammad poor A, Jalali M, Karimi G, Saberi H

EMHJ, 2010, 16 (6), 460-463

45. Exposure assessment for mercury from consumption of marine fish in Iran

Karimi G*, Moallem A, Hasanzadeh M, Bozorgi M, Nilli-Ahmadabadi A, Nazari F.

Toxicological & Environmental Chemistry . 2010, 92: 1213-1218

46. Effects of atorvastatin on nitrate tolerance in diabetic rats

Imenshahidi, M., Karimi, G., Kazemzadeh, E.

Iranian Journal of Pharmaceutical Research. 2010, 9: 55-59

47. Immunotoxicity of paraquat after subacute exposure to mice

Riahi, B., Rafatpanah, H., Mahmoudi, M., Memar, B., Brook, A., Tabasi, N., Karimi, G*.

Food and Chemical Toxicology. 2010, 48: 1627-1631

48. Evaluation of the Analgesic Effect of Dextromethorphan and its Interaction With Nitric

Oxide on Sciatic Nerve Ligated Rats

Karimi, G*., Tabrizian, K., Rezaee, R.

Journal of Acupuncture and Meridian Studies. 2010, 3: 38-42

49. Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against

oxidative stress

Soltani, F., Mosaffa, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F., Behravan, J.

Phytotherapy Research. 2010, 24: 85-89

50. In vitro evaluation of xanthine oxidase inhibitory activity of aqueous extracts of six

medicinal plants.

Roobakhsh, A., Karimi, G*.

Journal of Medicinal Plants. 2009, 8: 84-91+165

51. Persicasulphide C, a new sulphur-containing derivative from Ferula persica

Iranshahi, M., Noroozi, S., Behravan, J., Karimi, G., Schneider, B.

Natural Product Research .2009, 23: 1584-1588

52. Vasodilator effect of olive leaf aqueous extract and involvment of cyclooxygenase in the

rat aorta

Karimi, G.*, Imenshahidi, M., Jafarizaveh, E., Asgharian Rezaee, M.

Pharmacologyonline. 2009, 2: 365-371

53. Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes

exposed to oxidative stress

Soltani, F., Mosaffa, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F., Behravan, J.

Cell Biology and Toxicology. 2009,25: 291-296

54. Antigenotoxic effects of the disulfide compound persicasulfide A (PSA) on rat

lymphocytes exposed to oxidative stress

Noroozi, S., Mosaffa, F., Soltani, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F.,

Behravan, J.

Planta Medica. 2009,75::32-36

55. Contamination of patulin in clear apple juice in Mashhad, Iran

Karimi, G*., Hassanzadeh, M., Yazdanpanah, H., Nazari, F., Iranshahi, M., Nili, A.

Journal of Food Safety. 2008, 28: 413-421

56. Quantitative determination of methanol in plant water produced in Mashhad by

spectrophotometry method

Karimi, G*.., Hassanzadeh, M., Shahidi, N., Samie, Z.

Journal of Medicinal Plants. 2008, 7:56-59

57. Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum

marianum L. seed in mice

Karimi, G*., Saradeghi Keisari, M.

Journal of Medicinal Plants. 2007, 6: 38-43

58. In vitro protective effects of Satureja hortensis L. essential oil and ethanolic extract on

lymphocytes DNA

Behravan, J., Mosaffa, F., Karimi, G. Iranshahi, M.

Journal of Medicinal Plants. 2007, 6: 64-70

59. Protective effects of silymarin against free radical-induced erythrocyte lysis

Karimi, G*., Hassanzadeh, M., Mehri, S.

Journal of Complementary and Integrative Medicine. 2006, 3: article no. 8

60. The role of nitric oxide and protein kinase C in lipopolysaccharide- mediated vascular

hyporeactivity

Karimi, G*., Fatehi, Z., Gholamnejad, Z.

Journal of Pharmacy and Pharmaceutical Sciences. 2006, 9: 119-123

61. Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative

stress

Mosaffa, F., Behravan, J., Karimi, G., Iranshahi, M.

Archives of Pharmacal Research. 2006, 29:159-164

62. Protective effects of lycopene and tomato extract against doxorubicin-induced

cardiotoxicity

Karimi, G*., Ramezani, M., Abdi, A.

Phytotherapy Research. 2005, 19: 912-914

63. Cisplatin nephrotoxicity and protection by milk thistle extract in rats

Karimi, G*., Ramezani, M., Tahoonian, Z.

Evidence-based Complementary and Alternative Medicine. 2005, 2: 383-386

64. Anticonvulsant effect of Hypericum perforatum: Role of nitric oxide

Hosseinzadeh, H., Karimi, G. Rakhshanizadeh, M.

Journal of Ethnopharmacology. 2005, 98: 207-208

65. Evaluation of subacute toxicity of aqueous extract of Crocus sativus L. stigma and petal in

rats

Karimi, G*., Taiebi, N., Hosseinzadeh, Shirzad, F.

Journal of Medicinal Plants. 2004, 3: 29-35

66. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and

safranal, in mice

Hosseinzadeh, H., Karimi, G., Niapoor, M.

Journal of Medicinal Plants. 2004, 3: 48-58

67. Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice

Karimi, G*., Hosseinzadeh, H., Ettehad, N.

Phytotherapy Research. 2004, 18: 484-487

68. Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in

mice

Hosseinzadeh, H., Karimi, G., Rakhshanizadeh, M.

Journal of Medicinal Plants. 2004, 3: 23-30

69. Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models

in mice

Hosseinzadeh, H., Karimi, G., Ameri, M.

BMC Pharmacology. 2002, 2, art. no. 21

70. Effects of subacute lead acetate administration on nitric oxide and cyclooxygenase

pathways in rat isolated aortic ring

Karimi, G*., Khoshbaten, A., Abdollahi, M., Sharifzadeh, M., Namiranian, K., Dehpour, A.R.

Pharmacological Research. 2002, 46: 31-37

71. Attempted suicide by insulin injection treated with hypertonic glucose solution

Abdollahi, M., Jalali, N., Sharifzadeh, M., Karimi, G.

Medical Journal of the Islamic Republic of Iran .1998, 12: 85-87

a. Book:

1. Karimi, G and R Rezaee. Perchlorate. 2014 Elsevier- Encyclopedia of Toxicology, Third

Edition, 2014, 791–795 .

2. Karimi, G and P Lari, Tetrodotoxin . Elsevier .Encyclopedia of Toxicology, Third Edition, 2014,

515–518

3. Karimi, G and M Vahabzadeh, Thioxanthenes. Encyclopedia of Toxicology, Third Edition,

2014, 553–557

4. Karimi, G and M Vahabzadeh, Butyric Acid. Encyclopedia of Toxicology, Third Edition, 2014,

597–601

5. Karimi, G and M Rashedinia, Acrylamide. Encyclopedia of Toxicology, Third Edition, 2014,

69–73

6. Karimi, G and M Vahabzadeh, Killer Lakes. Encyclopedia of Toxicology, Third Edition, 2014,

40–42

Internal Congress:

Karimi G, Behravan J, Mosaffa F, Hosseinzadeh L, Bahrami G. Curcumin potentiates

doxorubicin induced apoptosis in h cardiac muscle cells through generation of reactive oxygen

spec.12 th Iranian congress of biochemistry & 4 th International congress of biochemistry and

molecular biology.Mashhad ,Iran, 6-9 September, 2011. PP(357)

Hosseinzadeh L, Karimi G .Vation of nuclear factor kappab by doxorubicin leads to ibition of

extrinsic pathway of apoptosis in H9c2 cells. 12 th Iranian congress of biochemistry & 4 th

International congress of biochemistry and molecular biology.Mashhad ,Iran, 6-9 September,

2011. PP(44)

Hosseinzadeh L, Karimi G. Effect of crocin and thymoquinone on doxorubicin- induced

cytotoxicity in H9c2 CELLS. Proceeding of 10th Annual Congress of Asia Pacific Association

of medical toxicology, Penang, Malaysia, 11-14 November 2011. PP(101)

Mehri F, Rezaee R, Hassanzadeh-Khayyat M, Karimi G . Assay of thiobencarb, aldicarb and

parathion in tap water and bottled mineral water in Mashhad, Iran. 11th International congress of

Toxicology, Mashhad, Iran, 13-15 September, 2011.(p195)