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Introduction to
BoroPharmContact: Andrew Cipa
Office: (888) 366-1496 x4Mobile: (586) 651-1143
E-mail: [email protected]
Company Overview Founded in 2003 around a new approach to making boron intermediates for use in Suzuki Couplings
• BoroPharm has evolved to become a specialty chemical development and manufacturing solutions provider
• Extremely talented team of chemist• 70% PhD’s with an average of 15+ years in process development
• World class facilities• Corporate offices (Novi, MI)• Research and development labs (Ann Arbor, MI)• Large-scale production, former Pfizer facility (Holland, MI)
Business Offerings Contract manufacturing services
• Quantities through 100 metric tons per year
• Custom synthesis solutions for difficult to source materials• Registered starting materials• Heterocycle development• Complex and advanced intermediates• High purity product specifications
• Process development expertise• Route scouting/development• Process Optimization• Systematic, design of experiment (DOE) approach
• Supply capability from research through full commercial scale• Allows for consistency in supply chain
Corporate Objectives
100% Customer Satisfaction!
Delivering Customer Satisfaction
• Guaranteed quality
• On-time delivery (>98% On-time delivery rate)
• Fail-safe raw material supply• Raw material procurement professionals with deep-rooted connections in emerging markets• Every project assigned an alternative raw material supply base, including in-house production
• Speed to delivery• We offer expedited production services designed to get products shipped quickly
• Frequent progress reports
Research and Development Ann Arbor, MI
Research and DevelopmentAnn Arbor, MI
• Fully equipped kilo lab (up to 100 L jacketed reactors)
• Reaction temperatures from -100 to +250 oC
• Numerous modified Parr hydrogenation instruments linked via auto-mated data collection system
• 1-4 L High-pressure Hastelloy reactors (up to 3000 psi)
• 40 L High-pressure Hastelloy reactor (up to 350 psi)
• High speed auto weighing, bottling, capping and labeling system
Research and Development SiteParr Hydrogenators
Research and Development SiteAuto Weighing Systems
Research and Development SiteHolland, MI
Commercial Production SiteHolland, MI
• 35,000 Liter total capacity (Ability to run 3 shifts, 7 days per week)
• Reaction temperatures from -100 to +250 oC• Hastelloy, stainless steel, and glass-lined jacketed reactors
(Sizes range from 200 L - 4,000 L)
• 3 x 800 L Hydrogenation reactors
• Production equipment includes:• Commercial tray dryers• Cogeim filter dryers• Rotary cone evaporators• Mill press• Neutsche jacketed filters• Large scale centrifuges
Commercial Production SiteHolland, MI
Delivering Quality
• Control production of all products• Raw materials receipt through product shipment
• In-house product analysis• Karl Fisher titration• Computrac moisture analysis• Gas chromatography• HPLC• GC/MS• LC/MS• NMR (• 1H, 13C, 11B,• 15N, 19F, etc.)• ICP Elemental Analysis (parts per trillion)
Commercial Production SiteWith Stellar Safety Record High pressure reactionsBorylationsZiegler-Natta catalysisCross coupling reactionsSkraup reactionChan-Lam couplingHalogenationsHydrogenations (Including asymmetric)CarbonylationsAminationsNitrationsGrignardsBirch reductions
Experience with Heterocycles
Imidazolinones Pyrazoles
Pyrazoles Thiophenes
Triazines Pyrimidines
Isoxazoles Oxazoles
... And many more
Why Would YOU Use BoroPharm?1) Looking for a product that has not been made commercially before
2) Seeking reliable source for specific product
3) Require optimization work on your synthetic processes
4) Tight campaign schedule requiring quick delivery
5) Secondary supply source
6) Solve internal capacity issues
7) Cannot risk IP theft with overseas suppliers
8) Cannot risk purity or timeline issues
How to Contact BoroPharm- Andrew Cipa
- Office: (888) 366-1496 x4
- Mobile: (586) 651-1143
- E-mail: [email protected]
- Domestic call: (248) 348-5776 - Fax: (248) 348-5760
- http://www.boropharm.com
