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February 2017 Volume 40, Number 2 In This Issue 159 In This Issue of Diabetes Care Commentary 161 DPP-4 InhibitorRelated Pancreatitis: Rare but Real! J.H. DeVries and J. Rosenstock Clinical Care/Education/Nutrition/Psychosocial Research 164 Pancreatic Safety of Sitagliptin in the TECOS Study J.B. Buse, M.A. Bethel, J.B. Green, S.R. Stevens, Y. Lokhnygina, P. Aschner, C.R. Grado, T. Tankova, J. Wainstein, R. Josse, J.M. Lachin, S.S. Engel, K. Patel, E.D. Peterson, and R.R. Holman, for the TECOS Study Group 171 The Effect of Canagliozin, a Sodium Glucose Cotransporter 2 Inhibitor, on Glycemic End Points Assessed by Continuous Glucose Monitoring and Patient-Reported Outcomes Among People With Type 1 Diabetes H.W. Rodbard, A.L. Peters, A. Slee, A. Cao, S.B. Traina, and M. Alba 181 Diabetes Device Use in Adults With Type 1 Diabetes: Barriers to Uptake and Potential Intervention Targets M.L. Tanenbaum, S.J. Hanes, K.M. Miller, D. Naranjo, R. Bensen, and K.K. Hood 188 Association Between Inpatient Sleep Loss and Hyperglycemia of Hospitalization R.H. DePietro, K.L. Knutson, L. Spampinato, S.L. Anderson, D.O. Meltzer, E. Van Cauter, and V.M. Arora 194 Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study) H.S. Bajaj, K. Venn, C. Ye, A. Patrick, S. Kalra, H. Khandwala, N. Aslam, D. Twum-Barima, and R. Aronson 201 Empagliozin as Add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Linagliptin and Metformin: A 24-Week Randomized, Double-Blind, Parallel-Group Trial E. Søfteland, J.J. Meier, B. Vangen, R. Toorawa, M. Maldonado-Lutomirsky, and U.C. Broedl 210 Personalized Diabetes Management Using Electronic Medical Records D. Bertsimas, N. Kallus, A.M. Weinstein, and Y.D. Zhuo Epidemiology/Health Services Research 218 Comparative Effectiveness of Diabetic Oral Medications Among HIV-Infected and HIV-Uninfected Veterans J.H. Han, K. Gordon, J.A. Womack, C.L. Gibert, D.A. Leaf, D. Rimland, M.C. Rodriguez-Barradas, and G.P. Bisson 226 Incidence Trends and Predictors of Hospitalization for Hypoglycemia in 17,230 Adult Patients With Type 1 Diabetes: A Danish Register Linkage Cohort Study K. Ishtiak-Ahmed, B. Carstensen, U. Pedersen-Bjergaard, and M.E. Jørgensen 233 Hormonal Contraception and Risk of Thromboembolism in Women With Diabetes S.H. OBrien, T. Koch, S.K. Vesely, and E.B. Schwarz 239 Among Low-Income Respondents With Diabetes, High-Deductible Versus No-Deductible Insurance Sharply Reduces Medical Service Use D.L. Rabin, A. Jetty, S. Petterson, Z. Saqr, and A. Froehlich Pathophysiology/Complications 246 Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes M. R ohling, A. Strom, G. B onhof, S. P uttgen, K. Bódis, K. Mussig, J. Szendr odi, D. Markgraf, S. Lehr, M. Roden, and D. Ziegler, for the German Diabetes Study Group 253 Urine Proteome Specic for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study J.-K. Yang, Y.-Y. Wang, C. Liu, T.-T. Shi, J. Lu, X. Cao, F.-Y. Yang, J.-P. Feng, C. Chen, L.-N. Ji, and A. Xu Cardiovascular and Metabolic Risk 261 High-Sensitivity Cardiac Troponin T (hs-cTnT) as a Predictor of Incident Diabetes in the Atherosclerosis Risk in Communities Study S.P. Whelton, J.W. McEvoy, M. Lazo, J. Coresh, C.M. Ballantyne, and E. Selvin 270 Association of Visit-to-Visit Variability of Systolic Blood Pressure With Cardiovascular Disease and Mortality in Primary Care Chinese Patients With Type 2 DiabetesdA Retrospective Population-Based Cohort Study E.Y.F. Wan, C.S.C. Fung, E.Y.T. Yu, D.Y.T. Fong, J.Y. Chen, and C.L.K. Lam Novel Communications in Diabetes 280 Growth Differentiation Factor 15 as a Novel Biomarker for Metformin H.C. Gerstein, G. Pare, S. Hess, R.J. Ford, J. Sjaarda, K. Raman, M. McQueen, S. Lee, H. Haenel, and G.R. Steinberg, for the ORIGIN Investigators Meta-analysis 284 Combined Analysis of Three Large Interventional Trials With Gliptins Indicates Increased Incidence of Acute Pancreatitis in Patients With Type 2 Diabetes I. Tk a c and I. Raz Errata 287 Erratum. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 2016;39:21262140 D. Young-Hyman, M. de Groot, F. Hill-Briggs, J.S. Gonzalez, K. Hood, and M. Peyrot 287 Erratum. George A. Bray, MD: Progress in Obesityd Multidisciplinary Research, Multidimensional Man. Diabetes Care 2016;39:14811485 D.H. Ryan, B.C. Hansen, and W.T. Cefalu Issues and Events 288 Issues and Events e-Letters Observations e6 Carbohydrate Estimation Supported by the GoCARB System in Individuals With Type 1 Diabetes: A Randomized Prospective Pilot Study L. Bally, J. Dehais, C.T. Nakas, M. Anthimopoulos, M. Laimer, D. Rhyner, G. Rosenberg, T. Zueger, P. Diem, S. Mougiakakou, and C. Stettler

In This Issue Diabetes Care...J.B. Hao, S. Imam, P. Dar, M. Alfonso-Jaume, N. Elnagar, and J.C. Jaume e-Letters – Comments and Responses e21 Comment on Cefalu et al. Update and Next

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Page 1: In This Issue Diabetes Care...J.B. Hao, S. Imam, P. Dar, M. Alfonso-Jaume, N. Elnagar, and J.C. Jaume e-Letters – Comments and Responses e21 Comment on Cefalu et al. Update and Next

February 2017 Volume 40, Number 2

In This Issue

159 In This Issue of Diabetes Care

Commentary

161 DPP-4 Inhibitor–Related Pancreatitis: Rare but Real!J.H. DeVries and J. Rosenstock

Clinical Care/Education/Nutrition/Psychosocial Research

164 Pancreatic Safety of Sitagliptin in the TECOS StudyJ.B. Buse, M.A. Bethel, J.B. Green, S.R. Stevens, Y. Lokhnygina,P. Aschner, C.R. Grado, T. Tankova, J. Wainstein, R. Josse,J.M. Lachin, S.S. Engel, K. Patel, E.D. Peterson, and R.R. Holman,for the TECOS Study Group

171 The Effect of Canagliflozin, a Sodium Glucose Cotransporter 2Inhibitor, on Glycemic End Points Assessed by ContinuousGlucose Monitoring and Patient-Reported Outcomes AmongPeople With Type 1 DiabetesH.W. Rodbard, A.L. Peters, A. Slee, A. Cao, S.B. Traina,and M. Alba

181 Diabetes Device Use in Adults With Type 1 Diabetes:Barriers to Uptake and Potential Intervention TargetsM.L. Tanenbaum, S.J. Hanes, K.M. Miller, D. Naranjo, R. Bensen,and K.K. Hood

188 Association Between Inpatient Sleep Loss andHyperglycemia of HospitalizationR.H. DePietro, K.L. Knutson, L. Spampinato, S.L. Anderson,D.O. Meltzer, E. Van Cauter, and V.M. Arora

194 Lowest Glucose Variability and Hypoglycemia Are ObservedWith the Combination of a GLP-1 Receptor Agonist andBasal Insulin (VARIATION Study)H.S. Bajaj, K. Venn, C. Ye, A. Patrick, S. Kalra, H. Khandwala,N. Aslam, D. Twum-Barima, and R. Aronson

201 Empagliflozin as Add-on Therapy in Patients With Type 2Diabetes Inadequately Controlled With Linagliptin andMetformin: A 24-Week Randomized, Double-Blind,Parallel-Group TrialE. Søfteland, J.J. Meier, B. Vangen, R. Toorawa,M. Maldonado-Lutomirsky, and U.C. Broedl

210 Personalized Diabetes Management Using ElectronicMedical RecordsD. Bertsimas, N. Kallus, A.M. Weinstein, and Y.D. Zhuo

Epidemiology/Health Services Research

218 Comparative Effectiveness of Diabetic Oral MedicationsAmong HIV-Infected and HIV-Uninfected VeteransJ.H. Han, K. Gordon, J.A. Womack, C.L. Gibert, D.A. Leaf, D. Rimland,M.C. Rodriguez-Barradas, and G.P. Bisson

226 Incidence Trends and Predictors of Hospitalization forHypoglycemia in 17,230 Adult Patients With Type 1Diabetes: A Danish Register Linkage Cohort StudyK. Ishtiak-Ahmed, B. Carstensen, U. Pedersen-Bjergaard, andM.E. Jørgensen

233 Hormonal Contraception and Risk of Thromboembolism inWomen With DiabetesS.H. O’Brien, T. Koch, S.K. Vesely, and E.B. Schwarz

239 Among Low-Income Respondents With Diabetes,High-Deductible Versus No-Deductible Insurance SharplyReduces Medical Service UseD.L. Rabin, A. Jetty, S. Petterson, Z. Saqr, and A. Froehlich

Pathophysiology/Complications

246 Differential Patterns of Impaired Cardiorespiratory Fitnessand Cardiac Autonomic Dysfunction in Recently DiagnosedType 1 and Type 2 DiabetesM. R€ohling, A. Strom, G. B€onhof, S. P€uttgen, K. Bódis, K. M€ussig,J. Szendr€odi, D. Markgraf, S. Lehr, M. Roden, and D. Ziegler, for theGerman Diabetes Study Group

253 Urine Proteome Specific for Eye Damage Can Predict KidneyDamage in Patients With Type 2 Diabetes: A Case-Controland a 5.3-Year Prospective Cohort StudyJ.-K. Yang, Y.-Y. Wang, C. Liu, T.-T. Shi, J. Lu, X. Cao, F.-Y. Yang,J.-P. Feng, C. Chen, L.-N. Ji, and A. Xu

Cardiovascular and Metabolic Risk

261 High-Sensitivity Cardiac Troponin T (hs-cTnT) as a Predictorof Incident Diabetes in the Atherosclerosis Risk inCommunities StudyS.P. Whelton, J.W. McEvoy, M. Lazo, J. Coresh, C.M. Ballantyne,and E. Selvin

270 Association of Visit-to-Visit Variability of Systolic BloodPressure With Cardiovascular Disease and Mortalityin Primary Care Chinese Patients With Type 2DiabetesdA Retrospective Population-BasedCohort StudyE.Y.F. Wan, C.S.C. Fung, E.Y.T. Yu, D.Y.T. Fong, J.Y. Chen,and C.L.K. Lam

Novel Communications in Diabetes

280 Growth Differentiation Factor 15 as a Novel Biomarker forMetforminH.C. Gerstein, G. Pare, S. Hess, R.J. Ford, J. Sjaarda, K. Raman,M. McQueen, S. Lee, H. Haenel, and G.R. Steinberg, for the ORIGINInvestigators

Meta-analysis

284 Combined Analysis of Three Large Interventional Trials WithGliptins Indicates Increased Incidence of Acute Pancreatitisin Patients With Type 2 DiabetesI. Tk�a�c and I. Raz

Errata

287 Erratum. Psychosocial Care for People With Diabetes:A Position Statement of the American Diabetes Association.Diabetes Care 2016;39:2126–2140D. Young-Hyman, M. de Groot, F. Hill-Briggs, J.S. Gonzalez, K. Hood,and M. Peyrot

287 Erratum. George A. Bray, MD: Progress in ObesitydMultidisciplinary Research, Multidimensional Man.Diabetes Care 2016;39:1481–1485D.H. Ryan, B.C. Hansen, and W.T. Cefalu

Issues and Events

288 Issues and Events

e-Letters – Observations

e6 Carbohydrate Estimation Supported by the GoCARB Systemin Individuals With Type 1 Diabetes: A RandomizedProspective Pilot StudyL. Bally, J. Dehais, C.T. Nakas, M. Anthimopoulos, M. Laimer,D. Rhyner, G. Rosenberg, T. Zueger, P. Diem, S. Mougiakakou,and C. Stettler

Page 2: In This Issue Diabetes Care...J.B. Hao, S. Imam, P. Dar, M. Alfonso-Jaume, N. Elnagar, and J.C. Jaume e-Letters – Comments and Responses e21 Comment on Cefalu et al. Update and Next

e8 Management of Hemoglobin Variants Detected Incidentallyin HbA1c Testing: A Common Problem Currently Lackinga Standard ApproachM.R. Lewis, R.C. Macauley, P.R. Sheehan, M.A. Staten, L.S. Phillips,N. Rasouli, and A.G. Pittas, on behalf of the D2d Research Group

e10 Screening for Type 1 Diabetes–, Thyroid-, Gastric-, andAdrenal-Specific Humoral Autoimmunity in 529 Children andAdolescents With Celiac Disease at Diagnosis Identifies asPositive One in Every Nine PatientsC. Tiberti, M. Montuori, F. Panimolle, C.M. Trovato, C. Anania,F. Valitutti, A.R. Vestri, A. Lenzi, S. Cucchiara, and S. Morano

e12 Extracorporeal Shockwave Therapy Improves FunctionalOutcomes of Adhesive Capsulitis of the Shoulder in PatientsWith DiabetesF. Santoboni, S. Balducci, V. D’Errico, J. Haxhi, M. Vetrano,G. Piccinini, A. Ferretti, G. Pugliese, and M.C. Vulpiani

e14 Plantar Shear Stress in Individuals With a History of DiabeticFoot Ulcer: An Emerging Predictive Marker for Foot UlcerationM. Yavuz, A. Ersen, J. Hartos, B. Schwarz, A.G. Garrett, L.A. Lavery,D.K. Wukich, and L.S. Adams

e16 Prevalence of Diabetes and Regional Differences inChinese Women Planning Pregnancy: A NationwidePopulation-Based Cross-sectional StudyQ. Zhou, Q. Wang, H. Shen, Y. Zhang, S. Zhang, and X. Li

e19 Extreme Insulin Resistance From Insulin Antibodies (NotInsulin Receptor Antibodies) Successfully Treated WithCombination Immunosuppressive TherapyJ.B. Hao, S. Imam, P. Dar, M. Alfonso-Jaume, N. Elnagar, andJ.C. Jaume

e-Letters – Comments and Responses

e21 Comment on Cefalu et al. Update and Next Stepsfor Real-World Translation of Interventions for Type 2Diabetes Prevention: Reflections From a Diabetes CareEditors’ Expert Forum. Diabetes Care 2016;39:1186–1201W.T. Garvey

e23 Response to Comment on Cefalu et al. Update andNext Steps for Real-World Translation of Interventionsfor Type 2 Diabetes Prevention: Reflections From aDiabetes Care Editors’ Expert Forum. Diabetes Care2016;39:1186–1201W.T. Cefalu, J.B. Buse, J. Tuomilehto, G.A. Fleming, E. Ferrannini,H.C. Gerstein, P.H. Bennett, A. Ramachandran, I. Raz, J. Rosenstock,and S.E. Kahn

e25 Comment on Pathak et al. Severe Hypoglycemia RequiringMedical Intervention in a Large Cohort of Adults WithDiabetes Receiving Care in U.S. Integrated Health CareDelivery Systems: 2005–2011. Diabetes Care2016:39;363–370P.D. Home

e26 Response to Comment on Pathak et al. SevereHypoglycemia Requiring Medical Intervention in a LargeCohort of Adults With Diabetes Receiving Care in U.S.Integrated Health Care Delivery Systems: 2005–2011.Diabetes Care 2016;39:363–370R.D. Pathak, E.B. Schroeder, E.R. Seaquist, C. Zeng,J.E. Lafata, A. Thomas, J.M. Lawrence, A.J. Karter,J.F. Steiner, J. Segal, and P.J. O’Connor, for the SUPREME-DMStudy Group

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