CHRONIC EBVINFECTIONBS. PHAM CHI TOAN

• 4 years of intermittent fever and abd pain

• 2019 cholesystectomy(bvdhyd)

• Laparotomy for nodal biopsy

• CR hospital for high fever and abd pain

INTRODUCTION

• Rare, fatal complication of EBV infection

• Children, adolescents

• Most common symptoms: fever, hepatitis, pancytopenia, splenomegaly

• Complications: interstitial pneumonia, lymphoma, liver failure, coronary artery

aneurysms, gastric carcinoma, myocarditis,peripheral neuropathy…

DIAGNOSIS CRITERIA

• Markedly abnormal antibody titers

• Histological evidence of major organ involvement(lymphadenitis, splenomegaly,

persistent hepatitis, uveitis

• Increased EBV RNA in affected tissue or increased level of EBV in peripheral

blood

TREATMENT

• Antiviral agents

• Immunosupressive drugs

• Cytotoxic T cells

• Hematopoietic cell transplatation