Cell Division and Apoptosis II

chapter 17

Activation of a cyclin dependent kinase

CdK activity can be suppressed by inhibitory phosphorylation

CdK activity can be suppressed by inhibitory proteins

Cell fusion experiments

Assembly of pre-replicative complex during G1 phase

Entry into mitosis is blocked by incomplete DNA replication

Hydroxyurea blocks DNA synthesisCaffeine causes failure of checkpoint

The Rb protein acts as a brake in mammalian cells

Overview of cell cycle control system

Programmed Cell Death - Apoptosis

Digits in developing mouse paw are formed through apoptosis

cells undergoing apoptosis

Apoptosis causes tadpole to lose tail

Necrosis vs. apoptosis

DVD clip 77

Procaspase is activated by an active caspase

Caspase cascade occurs during apoptosis

An animal cell depends on extracellular signals to survive or divide

An animal cell depends on extracellular signals to differentiate. Without extracellular signals the

cell will die

Platelet derived growth factor was the first mitogen isolated

stimulates cell division during wound healing

Mitogens stimulate G1-Cdk and G1/S-Cdk activities