DR  RANDY  BURD  ASST  VICE  PRESIDENT  

 UNIVERSITY  OF  ARIZONA    

NEXT GENERATION SEQUENCING: INFORMING NUTRITION AND AGRICULTURE

Randy Burd, Ph.D. Asst. Vice President, Program Innovation, Office of Global Initiatives Assoc. Professor, Nutritional Sciences, College of Agriculture and Life Sciences

Next Generation Sequencing •  The major limitation of

classical sequencing techniques is low throughput due to template preparation.

•  New approaches to DNA sequencing allow millions or even billions of reads to be carried out in parallel.

•  What are the implications for medicine and agriculture?

Opportunities in Health Care

0 1 2 3 4 5 6 7 8

1900 1950 1975 2000 2005 2010 2025

Technology Growth Cost & Inefficiency

Human Genome Project Complete: Inflection via biotechnology advancements

Discovery: Highly Inefficient & Technology Inappropriate C

ost &

Inef

ficie

ncy

Tech Appropriate Era: Consumer Technology now appropriately addresses needs and will maximize growth

Personalized Medicine • Prescribe more effective drugs and

avoid side effects. • Reduce time, cost, and failure rate

of pharmaceutical clinical trials. • Eliminate trial-and-error. • Shift the emphasis in medicine from

reaction to prevention. •  Functional Foods. • Nutritionally tailored foods.

Personalized Nutrition

Gene Protein Metabolite Response

Gene* Protein* Metabolite* Aberrant Response

Person A

Person B

•  Normal drug metabolism & response.

•  Nominal side effects.

•  Heightened drug metabolism & response.

•  Significant side effects.

Drug

Look at genes first and give drugs that match the genetic make-up

Drug *

beverage

sweets

Maps are rendered based on the number of times co-reported (J Med Internet Res 2013;15(6):e125)

Countries are the same color and borders may or may not have associations

ViBE Platform

Performance

Health

Fruit

ViBE can capture and identify patterns in intake and behavior, and relationships between foods and contextual factors

Morning

Mid-Day

Night

Heat Maps- can show changes through time

Relevance to agriculture •  Informing and supporting maximum efficiency in the

production of regionally-specific agricultural products that support overall health

Dynamic Heat Map, Real-Time Updates. Push! Can /map anything including BMI, SES, Genetics, Grades or Progress any Metric

Regional Context

Team Members University of Arizona

Randy Burd Melanie Hingle Donella Yoon Stephen Kobourov Matt Mars Ash Black Joe Fowler Mike Schneider Dan Falk

New Mexico State Barbara Chamberlin

Thomas Jefferson University Susan Lanza-Jacoby Frances Gilman