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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weivnann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series
Volume 523 ADVANCES IN MODELLING AND CLINICAL APPLICATION OF INTRAVENOUS ANAESTHESIA
Edited by Jaap Vuyk and Stefan Schraag
Volume 524 DIPEPTIDYL AMINOPEPTIDASES IN HEALTH AND DISEASE
Edited by Martin Hildebrandt, Burghard F. Klapp, Torsten Hoffmann, and Hans-Ulrich Demuth
Volume 525 ADVANCES IN PROSTAGLANDIN, LEUKOTRIENE, AND OTHER BIOACTIVE LIPID RESEARCH: Basic Science and Clinical Applications
Edited by Zeliha Yazlcl, Giancarlo Folco, Jeffrey M. Drazen, Santosh Nigam, and Takao Shimizu
Volume 526 TAURINE 5: Beginning the 21st Century
Edited by John B. Lombardini, Stephen W. Schaffer, and Junichi Azuma
Volume 527 DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM
Edited by Graziella Allegri, Carlo V. L. Costa, Eugenio Ragazzi, Hans Steinhart, and Luigi Varesio
Volume 528 ADAMANTIADES-BEHC;ET'S DISEASE
Edited by Christos C. Zouboulis
Volume 529 THE GENUS YERSINIA: Entering the Functional Genomic Era
Edited by Mikael Skurnik, Jose Antonio Bengoechea, and Kaisa Granfors
Volume 530 OXYGEN TRANSPORT TO TISSUE XXIV
Edited by Jeffrey F. Dunn and Harold M. Swartz
Volume 531 TROPICAL DISEASES: From Molecule to Bedside
Edited by Sangkot Marzuki, Jan Verhoef, and Harm Snippe
Volume 532 NEW TRENDS IN CANCER FOR THE 21ST CENTURY
Edited by Antonio Llombart-Bosch and Vicente Felipo
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
OXYGEN TRANSPORT TO TISSUE XXIV
Edited by
J effrey F. Dunn Harold M. Swartz Dartmouth Medical School Hanover, New Hampshire
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
International Society on Oxygen Transport to Tissue. Meeting (27th: 1999: Hanover, N.H.) Oxygen transport to tissue XXlV/edited by Jeffrey F. Dunn and Harold M. Swartz.
p. ; cm. - (Advances in experimental medicine and biology; v. 530) "Presentations made at the 27th Annual Meeting of the International Society on Oxygen
Transport to Tissue (lSOIT) .... held in Hanover, NH, USA, at Dartmouth Medical School"-Pref. Inc1udes bibliographical references and index. ISBN 978-1-4613-4912-9 ISBN 978-1-4615-0075-9 (eBook) DOI 10.1007/978-1-4615-0075-9
1. Oxygen-Physiological transport-Congresses. 2. Tissue respiration-Congresses. 1. Title: Oxygen transport to tissue 24. II. Title: Oxygen transport to tissue twenty-four. III. Dunn, Jeffrey F. (Jeffrey Frank). 1956- IV. Swartz, Harold M. V. Title. VI. Series.
[DNLM: 1. Oxygen Consumption-physiology-Congresses. 2. Biological Transport-physiology-Congresses. 3. Oxygen-metabolism-Congresses. WF 110 1610 2004] QP99.3.0915 1999 572'.47-dc21
2003050632
This is a proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue (ISOIT), held at Dartmouth Medical School, Hanover, New Hampshire, from August 28-September 2, 1999.
© 2003 Springer Science+Business Media New York Originally published by Kluwer Academic / Plenum Publishers, New York in 2003
http://www.wkap.nV
ill 9 8 7 6 5 432 1
A C.I.P. record for this book is available from the Library of Congress
AlI rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work
Permissions for books published in Europe: [email protected] Permissions for books published in the United States of America: [email protected]
INTERNATIONAL SOCIETY ON OXYGEN TRANSPORT TO TISSUE
1999
Officers President (1999) Past President (1998) President-Elect (2000) Secretary Treasurer Chairman of the
Knisely Award Committee
Executive Committee
David Benaron, USA Duane Bruley, USA Andras Eke, Hungary Simon Faithfull, USA David Harrison, UK Louis Hoofd, The Netherlands
Scientific Program Committee
International Britton Chance, USA David Delpy, UK David Harrison, UK P. W. Hochachka, Canada Antal Hudetz, USA Paul Okunieff, USA Peter Vaupel, Germany
Harold M. Swartz, USA Andras Eke, Hungary Berend Oeseburg, The Netherlands David F. Wilson, USA Peter E. Kiepert, USA
Duane F. Bruley, USA
Peter Kiepert, USA Josef Moravec, France Paul Okunieff, USA Berend Oeseburg, The Netherlands Oliver Thews, UK David Wilson, USA
Local Ted Abraham Donald Bartlett JeffF. Dunn Richard W. Dow Michael Gazzaniga David Glass Marsh Tenney Bernard Trumpower Keith Paulsen Peter Spiegel Harold M. Swartz
v
TECHNICAL EDITOR Laraine Visser-Isles, Erasmus University Rotterdam, Holland
VOLUME ADMINISTRATORS Elena Jmourova, Dartmouth College Virginia S. ("Dinny") Carreiro, Dartmouth College
SPONSORS The organizers of ISOTT99 are particularly grateful for the sponsorship of the following organizations:
AlIos Therapeutics Alliance Pharmaceutical Corporation Baxter Healthcare Corporation Biopure Corporation Bruker Instruments, Inc. Johnson & Johnson Oxford Optronix Reming Bioinstruments Co. Department of Neurology, Dartmouth Medical School Department of Radiology, Dartmouth Medical School
VB
PREFACE
This volume contains refereed manuscripts prepared from presentations made at the 2ih annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School, the 3rd oldest medical school in the USA. ISOTT attempts to produce high quality pUblications on cutting edge topics relating to oxygen in living systerns. The goal is to allow contributors to contribute original data, as with a main-stream journal article, but also to voice individual opinions and ideas in a more relaxed scientific forum.
The meeting brought together an international group of scientists who share a common interest in the measurement and role of oxygen in living systems. The organizers of ISOTT99 made a special effort to bring together people from industry, medicine, and basic sciences in order to improve the links in the chain of discovery through to application. As a result, this volume contains publications on a range of subjects. There are contributions from companies on modifiers of oxygen carrying capacity (allosteric modifiers of hemoglobin and infusible oxygen carriers or blood substitutes); technical reports on oxygen measurement devices including advances in near-infrared spectroscopy and imaging, oxygen electrodes, magnetic resonance spectroscopy and imaging, and fluorescence based measurements. There are medically related sections on modifying and measuring tumor oxygenation in order to improve therapy, assessment and interpretation of oxygenation in the central nervous system, and general issues relating oxygen to pathological conditions. There are special sections dealing with the issue of critical p02 in tissues, oxygen related gene activation, and protein C engineering.
We trust that you will find the volume as exciting and interesting as we have done in the preparation of this volume.
Jeffrey F. Dunn Harold M. Swartz
IX
CONTENTS
METHODS FOR ASSESSING OXYGEN IN TISSUES
1. MEASUREMENTS OF OXYGEN IN TISSUES: OVERVIEW AND PERSPECTIVES ON METHODS
Harold M. Swartz and Jeff F. Dunn
2. QUANTITATIVE BRAIN TISSUE OXIMETRY, PHASE SPECTROSCOPY AND IMAGING THE RANGE OF HOMEOSTASIS IN PIGLET BRAIN 13
Britton Chance, Hon Van Ma, and Shoko Nioka
3. TUMOR OXIMETRY: COMPARISON OF 19F MAGNETIC RESONANCE ECHO PLANAR IMAGING AND ELECTRODES 19
Ralph P. Mason, Sandeep Hunjan, Anca Constantinescu, Yulin Song, Dawen Zhao, Eric W. Hahn, Peter P. Antich, and Peter Peschke
4. MAPPING CEREBRAL GLUTAMATE l3C TURNOVER AND OXYGEN CONSUMPTION BY IN VIVO NMR 29
Fahmeed Hyder, Peter Brown, Terennce W. Nixon, and Kevin L. Behar
5. MONTE·CARLO SIMULATION OF LIGHT TRANSPORT FOR NIRS MEASUREMENTS IN TUMORS OF ELLIPTIC
GEOMETRY 41 Mojca Pavlin, Tomaz larm, and Damijian Miklavcic
6. ARTERIAL PULSA TlONS ARE PRESENT IN ONE THIRD OF THE HUMAN CRANIAL VASCULAR VOLUME PENETRA TED BY NEAR·INFRARED LIGHT 51
Robert Stingele, Emanuela Keller, Benedicht P. Wagner, Thorsten Steiner, Karoline Stingele, and Werner Hacke
Xl
Xll CONTENTS
7. ABSOLUTE FREQUENCY ·DOMAIN PULSE OXIMETRY OF THE BRAIN: METHODOLOGY AND MEASUREMENTS 61
Martin Wolf, Maria A. Franceschini, Lelia A. Paunescu, Vlad Toronov, Antonios Michalos, Ursula Wolf, Enrico Gratton, and Sergio Fantini
8. THE INFLUENCE OF A CLEAR LAYER ON NEAR·INFRARED SPECTROPHOTOMETRY: COMPARISON OF MEASUREMENTS IN A LIQUID NEONATAL HEAD PHANTOM TO INFANTS IN VIVO
Martin Wolf, Matthias Keel, Vera Dietz, Kurt von Siebenthal, Jan Teller, Hans-Ulrich Bucher, and Oskar Baenziger
9. STRA TEGIES FOR ABSOLUTE CALIBRATION OF NEAR
75
INFRARED TOMOGRAPHIC TISSUE IMAGING 85 Troy O. McBride, Brian W. Pogue, UlfL. Osterberg, and Keith D. Paulsen
10. BRAIN TISSUE AND SAGITTAL SINUS p02MEASUREMENTS USING THE LIFETIMES OF OXYGEN·QUENCHED LUMINESCENCE OF A RUTHENIUM COMPOUND 101
Casmiar 1. Nwaigwe, Marcie A. Roche, Oleg Grinberg, and JeffF. Dunn
11. PRELIMINARY STUDIES ON THE PHOTON PATH IN BREAST TISSUE MODEL BY NIR-TRS
Arisha L. Honar, Cory Ricks, and Kyung A. Kang
12. EPR SPECTROSCOPY AND IMAGING OF OXYGEN: APPLICA TIONS TO THE GASTROINTESTINAL TRACT
Jay L. Zweier, Guanglong He, Alexandre Samouilov, and Periannan Kuppusamy
PROTEIN C ENGINEERING ISSUES
13. EFFECTS OF BLOCKING BUFFERS AND PLASMA FACTORS ON
113
123
THE PROTEIN C BIOSENSOR PERFORMANCE i 33 Heath I. Balcer, James o. Spiker, and Kyung A. Kang
14. PROTEIN C SEPARATION FROM HUMAN BLOOD PLASMA DERIVATIVES USING LOW COST CHROMATOGRAPHY 143
Huiping Wu and Duane F. Bruley
CONTENTS
OXYGEN IN TUMORS
15. GLUTATHIONE DEPLETION OR RADIATION TREA TMENT ALTERS RESPIRATION AND INDUCES APOPTOSIS IN R3230AC MAMMARY CARCINOMA
John E. Biaglow, Intae Lee, Jerry Donahue, Kathy Held, John Mieyal, Mark Dewhirst, and Steve Tuttle
16. OXYGENATION AND VASCULAR PERFUSION IN SPONTANEOUS AND TRANSPLANTED TUMOR MODELS
Bruce M. Fenton and Scott F. Paoni
17. EFFECT OF MILD HYPERGLYCEMIA ± META·IODO· BENZYLGUANIDINE ON THE RADIATION RESPONSE OF R3230 AC TUMORS
Intae Lee, Jerry D. Glickson, Mark W. Dewhirst, Dennis B. Leeper, Randy Burd, Harish Poptani, Lydie Nadal, W. Gillies McKenna, and John E. Biaglow
18. EFFECT OF ONCONASE ± TAMOXIFEN ON ASPC·l HUMAN PANCREATIC TUMORS IN NUDE MICE
Intae Lee, Young H. Lee, Stanislaw M. Mikulski, and Kuslima Shogen
19 OXYGENATION IN A HUMAN TUMOR XENOGRAFT: MANIPULATION THROUGH RESPIRATORY
xiii
153
165
177
187
CHALLENGE AND ANTIBODY·DIRECTED INFARCTION 197 Ralph P. Mason, Anca Constantinescu, Sophia Ran, and Philip E. Thorpe
20. TUMOR pOl ASSESSMENTS IN HUMAN XENOGRAFT TUMORS MEASURED BY EPR OXIMETRY: LOCATION OF PARAMAGNETIC MATERIALS 205
Julia A. O'Hara, Rosalyn D. Blumenthal, Oleg Y. Grinberg, Stalina Grinberg, Carmen Wilmot, David M. Goldenberg, and Harold M. Swartz
21. HEMOGLOBIN IMAGING WITH HYBRID MAGNETIC RESONANCE AND NEAR·INFRARED DIFFUSE TOMOGRAPHY
Brian W. Pogue,Haoqin Zhu, Casmair Nwaigwe, Troy O. McBride, U1f L. Osterberg, Keith D. Paulsen, and Jeffrey F. Dunn
22. TUMOR OXYGEN DYNAMICS: COMPARISON OF 19F MR EPI AND FREQUENCY DOMAIN NIR SPECTROSCOPY
Yulin Song, Kate L. Worden, Xin Jiang, Dawen Zhao, Anca Constantinescu, Hanli Liu, and Ralph P. Mason
215
225
Xl V CONTENTS
23. MICROCIRCULATORY FUNCTION, TISSUE OXYGENATION, MICROREGIONAL REDOX STATUS AND ATP DISTRIBUTION IN TUMORS UPON LOCALIZED INFRARED-A-HYPERTHERMIA AT 42°C 237
Oliver Thews, Yanping Li, Debra K. Kelleher, Britton Chance, and Peter Vaupel
ENHANCING OXYGENATION
24. ALLOSTERIC MODIFICATION OF HEMOGLOBIN BY RSRl3 AS A THERAPEUTIC STRATEGY 249
Robert P. Steffen, Jean-Francois Liard, Michael J. Gerber, and Stephen J. Hoffman
25. THE PHARMACOLOGY OF TISSUE OXYGENATION BY BIOPURE'S HEMOGLOBIN-BASED OXYGEN CARRIER, HEMOPURE® (HBOC-201) 261
L. Bruce Pearce and Maria S. Gawryl
26. THE CONCEPT OF HEMOGLOBIN EQUIVALENCY OF PERFLUOROCHEMICAL EMULSIONS 271
N. Simon Faithfull
27. THE DOSE-DEPENDENT EFFECT OF RSRI3, A SYNTHETIC ALLOSTERIC MODIFIER OF HEMOGLOBIN, ON PHYSIOLOGICAL PARAMETERS AND BRAIN TISSUE OXYGENATION IN RATS
Oleg Y. Grinberg, Minoru Miyake, Huagang Hou, Robert P. Steffen, and Harold M. Swartz
28. COMPUTER MODELING OF RELATIONSHIP BETWEEN CRITICAL PV02, V02MAX AND BLOOD SUPPLY OF SKELETAL MUSCLE AT WORKING WITH A RIGHT-
287
SHIFTED BLOOD O2 DISSOCIA TION CURVE 297 Katherine G. Lyabakh and Irinia N. Mankovskaya
29. SMALL-VOLUME RESUSCITATION WITH THE HEMOGLOBIN SUBSTITUTE HBOC·20t: EFFECT ON BRAIN TISSUE OXYGENATION 311
Geoffrey T. Manley, 1. Claude Hemphill, Diane Morabito, Vanessa Erickson, John J. Holcroft, Nakita Derugin, and M. Margaret Knudson
CONTENTS XV
30. EFFECT OF RSR13, A SYNTHETIC ALLOSTERIC MODIFIER OF HEMOGLOBIN, ON BRAIN TISSUE pOl (MEASURED BY EPR OXIMETRY) FOLLOWING SEVERE HEMORRHAGIC SHOCK IN RATS 319
Minoru Miyake, Oleg Y. Grinberg, Huagang Hou, Robert P. Steffen, Hisham Elkadi, and Harold M. Swartz
31. EXPRESSION OF MYOGLOBIN IN THE TRANSGENIC MOUSE BRAIN
Ross D. Shonat and Alan P. Koretsky
CNS OXYGENATION
32. THE CEREBRAL MICROCIRCULATION IN ISCHEMIA AND HYPOXEMIA
Antal G. Hudetz
33. INVESTIGATING THE ROLE OF NITRIC OXIDE IN REGULA TING BLOOD FLOW AND OXYGEN DELIVERY FROM IN VIVO ELECTROCHEMICAL MEASUREMENTS
331
347
IN EYE AND BRAIN 359 Donald G. Buerk, Dmitriy N. Atochin, and Charles E. Riva
34. NIRS MONITORING OF PILOTS SUBJECTED TO +Gz ACCELERA TION AND G·INDUCED LOSS OF CONSCIOUSNESS (G·LOC)
Paul B. Benni, John K-J. Li, Bo Chen, Joseph Cammarota, and David W. Amory
35. CORRELATION OF NIRS DETERMINED CEREBRAL OXYGENA TION WITH SEVERITY OF PILOT +Gz ACCELERA TION SYMPTOMS
Paul B. Benni, John K-J. Li, Bo Chen, Joseph Cammarota, and David W. Amory
36. ALTERED GENE EXPRESSION FOLLOWING CARDIOPULMONARY BYPASS AND CIRCULATORY ARREST
Tatiana Zaitseva, Gregory Schears, Jin Shen, Jennifer Creed, David F. Wilson, and Anna Pastuszko
371
381
391
xvi
37. DOMINANT EVENTS THAT MODULATE MASS TRANSFER COEFFICIENT OF OXYGEN IN CERERAL CORTEX
Fahmeed Hyder, Ikuhiro Kida, Kevin L. Behar, Richard P. Kennan, and Douglas L. Rothman
38. RELATIONSHIP BETWEEN REDOX BEHAVIOR OF BRAIN CYTOCHROME OXIDASE AND NEUROLOGICAL PROGNOSIS
Yasuyuki Kakihana, Tomotsu Kuniyoshi, Sumikazu Isowaki, Kazumi Tobo, Etsuro Nagata, Naoko Okayama, Kouichirou Kitahara, Takahiro Moriyama, Takeshi Omae, Masayuki Kawakami, Yuichi Kanmura, and Mamoru Tamura
39. ARE YEP CORRELATED FAST OPTICAL SIGNALS DETECTABLE IN THE HUMAN ADULT BY NONINVASIVE NEAR-INFRARED SPECTROSCOPY (NIRS)?
Frank Syre, Hellmuth Obrig, Jens Steinbrink, Matthias Kohl, RUdiger Wenzel, and Arno Villringer
APPLICATION OF BOLD IMAGING
40. USING HIGH SPECTRAL AND SPATIAL RESOLUTION BOLD MRI TO CHOOSE THE OPTIMAL OXYGENATING TREATMENT FOR INDIVIDUAL CANCER PATIENTS
Hania A. Al-Hallaq, Marta A. Zamora, Brian L. Fish, Howard 1. Halpern, John E. Moulder, and Gregory S. Karczmar
41. ISSUES IN GRE & SE MAGNETIC RESONANCE IMAGING TO PROBE TUMOR OXYGENATION
Franklyn A. Howe, Simon P. Robinson, Loreta M. Rodrigues, Marion Stubbs, and John R. Griffiths
42. FMRI FOR MONITORING DYNAMIC CHANGES IN TISSUE OXYGENA TIONIBLOOD FLOW: POTENTIAL APPLICA TIONS FOR TUMOR RESPONSE TO CARBOGEN TREATMENT
Jianhui Zhong, W .C.Edmund Kwok, and Paul Okunieff
43. COMPARISON STUDY OF OXYGEN-INDUCED MRI-SIGNAL CHANGES AND pOz CHANGES IN MURINE TUMORS
Lothar Weissfloch, Michael Peller, Juergen Weber, Hans-Juergen Feldmann, Reingart Senekowitsch-Schmidtke, Karlheinz Tempel, Jeffrey A. Coderre, Michael Molls, and Michael Reiser
CONTENTS
401
413
421
433
441
449
461
CONTENTS xvii
MUSCLE OXYGENATION AND METABOLISM
44. VENOUS·ARTERIOLAR REFLEX IN HUMAN GASTROCNEMIUS STUDIED BY NIRS 467
Tiziano Binzoni, Loan Ngo, Massimo Girardis, Roger Springett, Fran~ois Terrier, and David Delpy
45. MUSCLE OXYGEN CONSUMPTION AT ONSET OF EXERCISE BY NEAR INFRARED SPECTROSCOPY IN HUMANS
Takafumi Hamaoka, Toshihito Katsumura, Norio Murase, Takayuki Sato, Hiroyuki Higuchi, Motohide Murakami, Kazuki Esake, Ryotaro Kime, Toshiyuki Homma, Akiko Sugeta, Yuko Kurosawa, Teruichi Shimomitsu, and Britton Chance
46. MODELING OF OXYGEN DIFFUSION FROM THE BLOOD VESSELS TO INTRACELLULAR ORGANELLES
Aleksander S. Popel, Daniel Goldman, and Arjun Vadapalli
47. MUSCLE REOXYGENATION RATE AFTER ISOMETRIC EXERCISE AT VARIOUS INTENSITIES IN RELATION TO MUSCLE OXIDATIVE CAPACITY
Ryotaro Kime, Toshihito Katsumura, Takafumi Hamaoka, Takuya Osada, Takayuki Sako, Motohide Murakami, Sang Yong Bae, Koji Toshinai, Shukoh Haga, and Teruichi Shimomitsu
48. OXYGEN DIFFUSION COEFFICIENT AND OXYGEN PERMEABILITY OF METMYOGLOBIN SOLUTIONS DETERMINED IN A DIFFUSION CHAMBER USING A NON·STEADY STATE METHOD
Iolanda P.W.M. Lamers-Lemmers, Louis I.C. Hoofd, and Berend Oeseburg
49. PINACIDIL·INDUCED OPENING, LIKE GLIBENCLAMIDE· INDUCED CLOSURE OF CARDIAC KATP CHANNELS, PROTECTS CARDIAC FUNCTION AGAINST ISCHEMIA IN ISOLATED, WORKING, ERYTHROCYTE
475
485
497
509
PERFUSED RAT HEARTS 519 Roger I. Legtenberg, Ralph I.F. Houston, Paul Smits, and Berend Oeseburg
50. EFFECT OF IRRADIATION ON ENZYMES OF THE CAPILLARY BED IN RAT VENTRICLES 527
Ming Gao, Hiroki Shirato, Kazuo Miyasaka, and Tomiyasu Koyama
xviii CONTENTS
CRITICAL pOl
51. THE REDOX STATE OF CYTOCHROME OXYDASE IN BRAIN IN VIVO: AN HISTORICAL PERSPECTIVE 535
Jospeh C. LaMalina
52. A QUANTITATIVE STUDY OF OXYGEN AS A METABOLIC REGULATOR
Krishnan Radhakrishnan, Joseph C. LaManna, and Marco E. Cabrera
53. THE OXYGEN DEPENDENCY OF CEREBRAL OXIDATIVE METABOLISM IN THE NEWBORN PIGLET STUDIED WITH 31p NMRS AND NIRS
Roger 1. Springett, Marzena Wylezinska, Ernest B. Cady, Veronica Hollis, Mark Cope, and David T. Delpy
54. EFFECT OF MYOGLOBIN INACTIVATION ON INTRACELLULAR GRADIENTS OF NADH FLUORESCENCE AT CRITICAL MITOCHONDRIAL OXYGEN SUPPLY
Eiji Takahashi, Hiroshi Endoh, Mizue Ishikawa, Machiko Kishi,and Katsuhiko Doi
55. EFFECTS OF ANESTHESIA ON CEREBRAL TISSUE OXYGEN TENSION: USE OF EPR OXIMETRY TO MAKE REPEA TED MEASUREMENTS
Harold M. Swartz, Satoshi Taie, Minoru Miyake, Oleg Y. Grinberg, Huagang Hou, Hisham EI-Kadi, and JeffF. Dunn
OXYGEN RELATED GENE ACTIVATION
56. CAPILLARIZA TION AND VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN HYPERTROPHYING ANTERIOR LATISSIMUS DORSI MUSCLE OF THE
547
555
565
569
JAPANESE QUAIL 577 Hans Degens, Rebecca K. Anderson, and Stephen E. Always
57. EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN IN RAT HEARTS SUBJECTED TO TRANSIENT ISCHEMIA FOLLOWED BY REPERFUSION 587
Tomiyasu Koyama, Zhonglin Xie, Jun'ichi Suzuki, and Kazuhiro Abe
CONTENTS xix
58. FIBROBLAST GROWTH FACTORS (FGFS) INCREASE BREAST TUMOR GROWTH RATE, METASTASES, BLOOD FLOW, AND OXYGENATION WITHOUT SIGNIFICANT CHANGE IN VASCULAR DENSITY 593
Paul Okunieff, Bruce M. Fenton, Lurong Zhang, Francis G. Kern, Timothy Wu, 1. Robert Greg, and Ivan Ding
59. MECHANISMS OF FGFl AND VEGF MEDIATED ANGIOGENESIS KHT TUMOR BEARING MICE 603
Ivan Ding, Weimin Liu, Jianzhong Sun, Scott F. Paoni, Eric Hernady, Bruce M. Fenton, and Paul Okun;eff
60. HIF·la AND VEGF EXPRESSION AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA 611
Paolo Pichiule, Faton Agani, Juan C. Chavez, Kui Xu,. and Joseph C. LaManna
61. RELATIONSHIP BETWEEN THE GENE EXPRESSION OF C·FOS AND DEGREE OF HYPOXIA IN RAT BRAIN, AS REVEALED BY NEAR·INFRARED SPECTROSCOPY 619
Yasutomo Nomura, Masataka Kinjo, and Mamoru Tamura
OXYGEN METABOLISM AND PATHOPHYSIOLOGY
62. BLOOD VOLUME CHANGES ARE CONTROLLED CENTRALLY, NOT LOCALLY· A NEAR·INFRARED SPECTROSCOPY STUDY OF ONE·LEGGED AEROBIC EXERCISE 627
Chris E. Cooper and Caroline Angus
63. A MODELING INVESTIGATION TO THE POSSIBLE ROLE OF MYOGLOBIN IN HUMAN MUSCLE IN NEAR INFRARED SPECTROSCOPY (NIRS) MEASUREMENTS 637
Louis Hoofd, Willy Colier, and Berend Oeseburg
64. TISSUE HYPOXIA DURING BACTERIAL SEPSIS IS ATTENUATED BY PR·39, AN ANTIBACTERIAL PEPTIDE 645
Philip E. James, Melani Madhani. Chris Ross. Linda Klei, Aaron Barchowsky. and Harold M.Swartz
xx CONTENTS
65. EFFECTS OF THE CONTRAST MEDIUM IOPROMIDE ON RENAL HEMODYNAMiCS AND OXYGEN TENSION IN THE DIABETIC RAT KIDNEY 653
Fredrick Palm, Per-Ola Carlsson, Angelica Fasching, Olof Hellberg, Anders Nygren, Peter Hansell, and Per Liss
66. POSTOCCLUSIVE REACTIVE HYPEREMIA IN HEALTHY VOLUNTEERS AND PATIENTS WITH PERIPHERAL VASCULAR DISEASE MEASURED BY THREE NONINVASIVE METHODS
Tomai Jarm, Rudi Kragelj, Aadam Liebert, Piotr Lukasiewitz, Tatjana Erjavec, Marketa Pr~eren-Strukel, Roman Maniewski, Pavle Poredo§, and Damijan Miklav~i~
67. ROLE OF MYOGLOBIN IN REGULATING RESPIRATION Thomas Jue and Youngran Chung
68. OXIDATIVE DEFENSES IN THE SEA BASS, DICENTRARCHUS LABRAX
Giulia Guerriero, A1essandra Di Finizio, and Gaetano Ciarcia
69. RHEOLOGIC DISSIMILARITIES IN FEMALE AND MALE BLOOD: POTENTIAL LINK TO DEVELOPMENT OF CARDIOVASCULAR DISEASES
Marina V. Kameneva, Mary 1. Watach, and Harvey S. Borovetz
70. PRELIMINARY STUDIES OF THE APPLICATION OF NEAR INFRARED SPECTROSCOPY IN THE DIAGNOSIS OF DEEP VEIN THROMBOSIS
Lino K. Korah, Frederick D. Scott, G. Melville Williams, and Kyung A. Kang
71. CEREBROVASCULAR RESPONSE TO ACUTE METABOLIC ACIDOSIS IN HUMANS
Marjo 1.T. Van de Ven, Willy N.J.M. Colier, Bregina T.P. Kersten, Berend Oeseburg, and Hans Foigering
72. FREE FLAP MONITORING IN PLASTIC AND RECONSTRUCTIVE SURGERY
John A. Pickett, Maureen S. Thorniley, Nigel Carver, and Deric P. Jones
661
671
681
689
697
707
717