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10 Week End Stage
Wt 4 Week
11
Modeling PDAC metastasis
orthotopic
de novo
22
Phenotype of PDAC does not appear to be differentPhenotype of PDAC does not appear to be differentin Smo F/+ and in Smo F/F mice at 9.5 weeks of agein Smo F/+ and in Smo F/F mice at 9.5 weeks of age
PDACPDACSmo F/+Smo F/+
PDACPDACSmo F/FSmo F/F
200x 200x
33
PDACPDACSmo F/+Smo F/+
PDACPDACSmo F/FSmo F/F
400x400x
Phenotype of PDAC does not appear to be differentPhenotype of PDAC does not appear to be differentin Smo F/+ and in Smo F/F mice at 9.5 weeks of agein Smo F/+ and in Smo F/F mice at 9.5 weeks of age
44
PDACPDACSmo F/+Smo F/+
PDACPDACSmo F/FSmo F/F
55PanINsPanINs
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x
66930
66
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 200x
66930
77
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x
67397
88
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 200x
67397
99
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 100x
67410
1010
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 200x
67410
1111
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 100x
66943
1212
9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 200x
66943
1313