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:Multiple Myeloma : - : -

Multiple Myeloma ETIOLOGY

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MM plasma cells malignant plasma cells :BM replacementBone destructionParaprotein formation Definition

MM . . MM :Farmers Petroleum workers MM

70 . 40 . . MM malignancies 1-2% malignancies 13-33% . MM

MM - Pacific .......

Pathogenesis of multiple myeloma: MM BM stromal MM cells . MM cells BM stromal cells IL-6 ILG-1 VEGF SDG-alpha 1 . (Fig. 111-3).

Multiple Myeloma

plasma cells B-lymphocytes plasma cells Antibodies . plasma cells plasma immunoglobulins Paraproteins ........... .........