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Compiled byMrs J Wright, Durban Girls’ High School,2006
The Problem – an Ulcer!
Definition : ulcer n. an open sore on an external or internal surface
Slide 1
Ulcers – found in the stomach lining, and though to be caused by stressful living.
Slide 2
Using an endoscope to view an ulcer and a tissue sample then taken to be analysed
View of an ulcer in the stomach
Slide 3
Dr Robin Warren - pathologist
Team work
The curious observation made by Dr Robin Warren in the samples given to him to analyse.These observations were investigated by Dr Marshall.
Slide 4
In the laboratory.Team work to producea culture of H. pylori!
Slide 5
Dr Barry Marshall – 1981, Australia
Slide 6
Culture of Helicobacter pylori
A sample was taken and viewed under theElectron Microscope
After months of trials and failures,an unplanned long weekend in the incubatorproduced a result!
Slide 7
Helicobacter pylori
The villian!A
B C
Slide 8
Removal of H. pyloriand healing of the ulcer?Scanning E.M of H.pylori on
the stomach walls.
Slide 9
How the ulcer is formed
H. pylori causes excess production of HCl by cells of the stomach lining. The stomach is trying tokill the bacterium.
The excess acid removesthe mucus layer and thestomach cells are then attacked,resulting in an ulcer.
Acid inhibitors such as Tagamet now usually prescribed for relief but they have to be taken continually.
Slide 10
Test kits forHelicobactera pylori
Slide 11
Drinking the urea solution:
Blowing out into a test tube.
Slide 12
H. pylori breath test – gas chromatograph reads results.
Slide 13
How the test works.Ammonia identified in exhaled air.This is due to H. pylori conversion ofUrea into ammonia.
Slide 14
Results that provide further proof of the connection between H pylori and ulcers.
H pylori removed within 2 weeks after taking antibiotics!
Slide 15
Communicating their findings
Slide16
Book: The Ease & Difficulty of a New Discovery.
Author: Robin Warren
Acceptance at last!
Slide17
Slide 18
Nobel prize announced - 2005
From initial discovery in1981 until acknowledgmentby the scientific communityin 2005!
Slide 19
H. pylori in the blood
Spread by povertyand down throughthe families!
Now thoughtto be responsible for stomach cancer and heart disease. RemoveH pylori and reduce the risk!
Further findings…
Simple prevention!
Slide 20