Ospedale Evangelico Villa Betania Fondazione Evangelica Betania U.O.S. di Anatomia ed Istologia Patologica Responsabile: dott.ssa Rosa Giannatiempo. U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1. Le molecole di adesione intercellulare negli aborti spontanei: studio immunoistochimico - PowerPoint PPT Presentation
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Ospedale Evangelico Villa BetaniaFondazione Evangelica
BetaniaU.O.S. di Anatomia ed Istologia PatologicaResponsabile:
dott.ssa Rosa Giannatiempo
Le molecole di adesione intercellulare negli aborti spontanei:
studio
immunoistochimicoM.PostiglioneA.MaglioneA.RussoA.NicastroD.OppressoreA.PintoC.TrombettaR.Giannatiempo
Early placental development is associated with complex
regulatory mechanisms, and molecular pathways involved during
placental development are critical for pregnancy progression.
Background
ObjectiveWe examined the role of adhesion molecules in the
mechanism of spontaneous abortions.
STUDY DESIGN 2008:MaterialsI Trimestre35II Trimestre30III
Trimestre20hhh
Results:CD31 Microvascular density (MVD) through CD31,
decreased. Statistically significant differences have been detected
between spontaneous abortion materials in the first trimester
compared to those of abortions in the 2nd and the 3th trimesters
with regard to cytotrophoblasts (CTs), syncytiotrophoblasts (STs),
and extravillous trophoblasts (EVTs) (p
E-cadherin expression in cytotrophoblasts (CTs), and in
syncytiotrophoblasts (STs), (p
Decreased MVD in CTs in spontaneous abortion cases can suggest
that MVD is critical in uteroplacental adequacy. Moreover,a
down-regulation of E-cadherin could be responsible for impaired CTs
differentiation and loss of the pregnancy. Furthermore, decreased
CD44 expression in D cells may be cause of impairing stroma-villous
connections.Their analysis in spontaneous abortions will provide
useful information for clarifying the physiopathology of
spontaneous abortions. Conclusions
