Life sciences, healthcare and medical technology

Enabling progress in innovation

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ttopstart is a consultancy firm for business generation in the life sciences, healthcare and medical technology. We deliver the intelligence required for strategic decisions, develop strong business plans and realise business and project financing. ttopstart is passionate to turn groundbreaking innovations into profitable products and services. • INTELLIGENCE • TRUST • QUALITY

About us

life sciences

technology

healthcare

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SECTORS

Life SciencesNovel medication for cancer patients, reliable diagnoses based on gene profiling, enzymes as catalyst in chemistry: innovations in the Life sciences bring valuable technolo-gies to society. However, successful commercialisation of innovations is a major challenge due to hard to raise financing, long development trajectories, strict regula-tions and difficult reimbursement models. We work from the premise that science has to be combined with market intelligence to optimally leverage valuable innovations in this challenging sector. HealthcareIncreasing market force, pressure on reimbursement, an aging population, demanding patients and automation threaten the quality of healthcare. Innovations can con-tribute in many ways to maintain and improve this quality. In order to successfully introduce and finance healthcare innovations ttopstart supports healthcare organizations during the entire innovation process. Doing so, new prod-ucts, services and processes are successfully implemented in daily practice.

Medical TechnologyImproved MRI scan results, 3D simulation of the human body, telemonitoring of hearth patients: high-tech research delivers exiting new technologies with a large impact on existing medical practice. In contrast the market is highly competitive, products have a short life cycle and the transparency in the application areas is not eminent. It is our commitment to identify the challenges that your tech-nology will face and anticipate accordingly.

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The healthcare and life sciences market is highly competitive and promising research does not guarantee successful commercialisation. Under influence of defiant conditions your business should be cleverly shaped. ttopstart is specialised in analysing the options for com-mercial activity and in calculating feasibility of different concepts. Based on such crucial information we offer support in setting up a strong business plan. With our support, a number of clients has been able to determine the best route of commercialisation and to convince stake-holders and investors of their business concept. By sup-porting business development activities, ttopstart is able to offer entrepreneurs and organizations the extra tools to manage a healthy business.

BUSINESS DEVELOPMENT

Business Planttopstart offers the service to set up a sound and per-suasive business plan for new activities. It is our task to visualise your plans, deliver key market insights and assess commercial and financial feasibility. Your business plan with ttopstart label will allow you to objectively review the concept and to convince investors to provide financial backup. Business CaseIn early stages of commercialisation a business case offers rapid insight in the added value of innovations. Such docu-ment is helpful to inform third parties on your plans and allows you to quickly oversee commercial routes. This gives you the essential basis for further development. ttopstart is dedicated to support you in formulating a well-struc-tured business case, built on relevant market information.

Project ManagementDuring innovation processes it is crucial to initiate and continue management activities in addition to product development. We are able to support you in carrying part of these responsibilities. Please contact us for more information.

Prof. Dr. A.M. (Ada) Kruisbeek, CEO/CSO DCPrime B.V.

“Thanks to ttopstart, DCPrime has access to market insights and other intelligence needed for preparation of its VC and company presentations.”

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Reliable market information is of key importance in set-ting up business activities. Strategic decisions have to be based on insights in market size, segmentation, the competitive landscape, the latest state of art and reim-bursement options. Besides, the IP landscape influences the potential of winning a strong market position. For this reason it is crucial to identify key opportunities and to determine the market impact of your innovation. By consulting key opinion leaders and market players we are able to map niche markets, identify critical unmet medical needs and recognise interesting business oppor-tunities. Based on the objective market view generated by ttopstart, you will be able to comprehend commercial and technological feasibility.

Market researchIn landscaping your market, we use our extensive network and consult direct stakeholders and experts. Furthermore, we dig into proprietary databases and analyse competi-tive behavior. We present these data in a transparent and structured report and talk you through the most impor-tant conclusions. This will not only give you an apprehen-sion of market statistics and trends, but also provides you with essential information on potential customers and market opportunities. IP LandscapingBy mapping the IP landscape of your innovation we offer you insight into potential prior art and into competitive activities. We are skilled in patent database searches and deliver a lucid IP overview.

INTELLIGENCE

“For the VIRGO consortium, we are continuously looking for new opportunities for which a business plan or market analysis is essential. ttopstart has gained our trust by delivering high-quality information for decision making.” Prof.Dr. E.H.J.H.M (Eric) Claassen, Valorisation Manager VIRGO Consortium and CEO of Vironovative BV

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For every business activity, financing is essential. ttopstart supports by mapping the financing opportunities and actively contributes in their raising. It is our expertise to support the financing of the following activities:

• Translational research• Commercialisation or valorisation of research• Start an innovative company• Upscaling and internationalisation of commercial activities• Targeting new markets• Starting innovative healthcare concepts• Strengthening of your proposition towards industry

For this, we use a wide variety of financial resources, including national and international subsidies, patient societies and funds, bank loans, innovation credit, tax incentives and risk capital.

SubsidiesThe ttopstart team has a background in both life sciences/healthcare and business and is therefore able to rapidly translate scientific concepts into strong propositions. We are specialised in translational and commercially targeted subsidies.

Subsidy scanWe can provide you with a complete and tailored overview of subsidies and other financial means for which your company or project is eligible. Private capitalVenture capital, bank loans and innovation credit: ttopstart provides optimal advice to maximize your finance possi-bilities.

FINANCING

“The application for subsidies and grants is extraordinary complex. ttopstart offered us the most promising opportu-nities and a realistic outlook on the chance for success. It is pleasant that they support you during the whole process. So far we have received all the grants we applied for thanks to the support of ttopstart.”

Dr. S.A. (Servaas) Morré, CSO Microbiome Ltd.

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The TU/e Innovation Lab in Eindhoven fulfils an active and supportive role in relation to knowledge valorisation and innovation. They encourage entrepreneurship by identifying, supporting and providing guidance for potential high-tech startups and spin-off companies originating at the TU Eind-hoven. For innovative research in Eindhoven the assistance of the Innovation Lab is probably the most familiar first step towards commercial success.

The Innovation Lab works together with ttopstart on several projects to offer promising researchers the tools they need for optimal valorisation. The role of ttopstart in assisting these projects is diverse. Depending on the needs of the clients, the Innovation Lab asks ttopstart to take care of either a business plan; to carry out market research or to assist in acquiring public and private capital for a project.

As a team the TU/e Innovation Lab and ttopstart were able to assist the valorisation of promising research projects in medical technology and healthcare. The trustworthy relation has resulted in the successful progress of cutting edge tech-nology towards society and industry.

Steef Blok: “For us, ttopstart delivers capacity and profes-sionalism. They have the brains to deliver high quality products that make us able to assist promising research even better. Our projects are highly divers. The flexibility of ttopstart makes it possible to join forces on a variety of projects.”

CLIENT PROFILES

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Microbiome Ltd. is a molecular diagnostics company in the field of infectious diseases. As a spin-off from the VU Univer-sity medical center in Amsterdam, Microbiome is active in the discovery, manufacturing and marketing of microbiological techniques, tools, systems and characterisations. In 2008 the company received the Amsterdam Innovation Award for the groundbreaking research concerning Chlamydia testing and in 2011 they were nominated for the FD-Gazellen award

One of the R&D programs of Microbiome is the development of a certified host genetic based diagnostic test to assess Chlamydia trachomatis (CT) and other Sexually Transmitted Diseases (STD) associated tubal damage in subfertile women to triage subfertile better for laparoscopy as compared to CT serology only.

To realise sufficient funding for R&D, Microbiome works together with ttopstart. In a close cooperation ttopstart investigated the possibilities for Microbiome to receive funding for the development of the genetic test. After select-ing the most promising funding possibilities, it was decided to apply for a European and National subsidy program.

Because setting up a subsidy application is a time consum-ing task that requires full attention, ttopstart took care of the complete process. To make the proposition as persuasive and lucid as possible multiple experts within the field and key decision makers where consulted.

Microbiome successfully applied for a EuroTransBio grant of 660.000 EUR for the development of the diagnostic test. The grant enables the company to further develop the diagnostic test.

Dr. Servaas Morré: “The application for subsidies and grants is extraordinary complex. ttopstart offered us the most promising opportunities and a realistic outlook on the chance for success. It is pleasant that they support you during the whole process. So far we have received all the grants we applied for thanks to the support of ttopstart.”Patrick de Boer MSc: “Microbiome has several promising R&D projects that are close to market. Therefore, we sup-ported Microbiome in attracting funding specifically for SMEs. With these proceeds, Microbiome is able to validate, certify and market their diagnostic test”.

BilthovenP.C. Staalweg 30 3721 TJ BilthovenTel: +31 30 73 70 779

Mailing addressPostbus 78811008 AB Amsterdam

info@ttopstart.nlwww. ttopstart.nl

Contact

www.ttopstart.nl