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Opportunities for SMEs in Horizon 2020 Horizon 2020 experts

Horizon 2020 for SMEs - ttopstart, the Horizon 2020 experts

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Horizon 2020 is the foremost non-dilutive funding opportunity for research-intensive industry to finance and accelerate research and innovation activities. The aim of Horizon 2020 is to advance scientific knowledge and discovery, while securing Europe’s growth and global competitiveness through stronger involvement of industry and in particular SMEs.

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Page 1: Horizon 2020 for SMEs - ttopstart, the Horizon 2020 experts

Opportunities for SMEs in Horizon 2020

Horizon 2020 experts

Page 2: Horizon 2020 for SMEs - ttopstart, the Horizon 2020 experts

Ontwerp: Studio Edwin de Boer 2

ttopstart - Horizon 2020 experts

Page 3: Horizon 2020 for SMEs - ttopstart, the Horizon 2020 experts

Horizon 2020 experts

Opportunities for SMEs in Horizon 2020

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Horizon 2020: the EU Framework Programme for Research and Innovation

Horizon 2020 is the European grant and sub-sidy framework for innovation and R&D. The programme, running from 2014 to 2020, has a budget of €70 billion. Horizon 2020 aims to secure Europe’s global competitiveness.

Horizon 2020: the perfect opportunity for SMEs To promote industrial growth and tackle societal challenges, Horizon 2020 takes advantage of a market-driven approach, providing seamless and coherent funding from idea to market. Small and Medium-sized Enterprises (SMEs) are encouraged to participate across Horizon 2020 programmes. Within the Horizon 2020 programmes, many opportunities arise for SMEs to fund early-stage, high-risk research and innovation, including clinical trials. The Horizon 2020 programmes aim to accelerate R&D activities and stimulate breakthrough innovations.

The simplified architecture of the Horizon 2020 programme - bringing together all European research and innovation funding - makes it easier for SMEs to identify funding opportunities and apply for participation. A minimum of 20%, or about €8.65 billion, of the total combined budgets of 'Leadership in enabling and industrial technologies' (LEITs) and ‘Societal Challenges’ is designated to SMEs.

Non-dilutive funding for SMEs is provided for research, development and innovation activities, including:• Development of lead product or process;• Innovation in product pipeline;• Gathering clinical evidence;• Introduction of disruptive technologies;• Collaborative projects with academia;• Training, mobility and career

development of researchers.

What is Horizon 2020?

Horizon 2020 is the foremost non-dilutive funding opportunity for research-intensive industry to finance and accelerate research and innovation activities. The aim of Horizon 2020 is to advance scientific knowledge and discovery, while securing Europe’s growth and global competitiveness through stronger involvement of industry.

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Excellentscience

Industrial leadership

Societalchallenges

∙ European Research Council∙ Marie Sklodowska-Curie Actions∙ Future and Emerging technologies∙ Research infrastructures

∙ Health, demographic change and wellbeing∙ Inclusive, innovative and secure societies

∙ Leadership in enabling and industrial technologies∙ Access to risk finance∙ Innovation in SMEs

Horizon 2020:key features• Increased participation of industry,

including SMEs Research and development within Public Private Partnerships is promoted,

e.g. through increased participation of industry, including SMEs.

• Six specific types of actions Horizon 2020 consists of six different types of actions (project types), each

with their own set of provisions and funding rates. Collaborative research and innovation projects are part of Research and Innovation Actions (RIA), Innovation Actions (IA) and the SME-instrument.

• Simplified set of financial rules The EU contribution is up to 100% of the total eligible costs for R&D projects

and up to 70% for innovation projects. In all cases, indirect costs will be covered by a flat rate of 25% of the direct costs.

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Funding opportunities for SMEsIn Horizon 2020

Eurostars SME instrument

Consortium Min. 2 legal entities One for-profit-SME (small consortium of SMEs possible)

Project type (specific for medical innovation)

Preclinical Clinical

Maturity of technological innovation

Innovation validated in lab (on the market/ in clinical trials within 2 years after completion of project)

Innovation validated in relevant environment (e.g. innovation ready for clinical validation or pilot studies)

Funding ~ c0.5M/ partner(depends on national rules)

Max €2.5M/ project(PHC12 = max €5M)

Theoretical success rate (based on number of projects submitted and funded)

23% ~10%

Topics Development of any product, process or service

- Biomarkers/ Diagnostics - Nanotechnology- Biotechnology- ICT

Focus/Aim Increased internationalisation potential of SMEs

Support fast-growing SMEs

Several funding instruments are incorporated that offer non-dilutive funding support to SMEs. The funding instruments facilitate the acceleration of R&D activities and stimulate breakthrough innovations.

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Eurostars SME instrument

Consortium Min. 2 legal entities One for-profit-SME (small consortium of SMEs possible)

Project type (specific for medical innovation)

Preclinical Clinical

Maturity of technological innovation

Innovation validated in lab (on the market/ in clinical trials within 2 years after completion of project)

Innovation validated in relevant environment (e.g. innovation ready for clinical validation or pilot studies)

Funding ~ c0.5M/ partner(depends on national rules)

Max €2.5M/ project(PHC12 = max €5M)

Theoretical success rate (based on number of projects submitted and funded)

23% ~10%

Topics Development of any product, process or service

- Biomarkers/ Diagnostics - Nanotechnology- Biotechnology- ICT

Focus/Aim Increased internationalisation potential of SMEs

Support fast-growing SMEs

Fast Track to Innovation Marie Curie ITN- EID Collaborative projects

3-5 legal entities, half or more from industry Min. 2 legal entities Min. 3 legal entities

Late phase clinical/ commercialisation Any Any (dependent on call)

Innovation validated in relevant environment(on the market no later than 3 years after start of FTI project)

Any Any (dependent on call)

Max €3M/ project €3M- €4M /project €3M- €6M /project

Not yet available (~ 60 projects)

~19% ~3%

Any LEIT/SC focus area of Horizon 2020 (amongst others: nanotech, biotech, ICT, personalised medicine)

Not specified (bottom-up funding)

Top down, specific calls

Accelerate commercialisation of products, processes or services

Involving the non-academic sector in doctoral training

Highly innovative research

A number of topics focus on SMEs by setting apart a major part of the budgetfor R&D activities for SMEs. The size, scope and internal organisation of projects are defined in the various Work Programmes. Key opportunities for participation and support of SMEs in Horizon 2020 are highlighted in the table. For a detailed description of funding instruments dedicated to SMEs please contact our consultants.

EurostarsResearch-intensive SMEs can acquire funding through Eurostars 2, the follow-up of the successful Eurostars programme. Eurostars aims to support R&D performing SMEs by co-financing market-oriented innovation with a bottom-up approach. Eurostars projects are transnational, with at least two partners (one of which has to be a research-performing SME). Depending on national rules, non-SME collaborators can be eligible for funding.

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Phase 1:Concept and feasibility assessment

Phase 2: R&D, Demonstration, Market replication

Phase 3: Commercialisation

Lump sum: €50.000 ~ 6 months

€0.5-5 M per project~ 12 to 24 months

No direct funding

Investor-ready business plan

Elaborated business plan

Idea: Short business plan

SME instrumentThe SME instrument aims to fill gaps in funding for early-stage, high-risk research and innovation as well as stimulating breakthrough innovations by SMEs. Single company support is possible. Although collaborations can be part of the project, only SMEs can acquire funding through this instrument. Staged support in 3 phases will cover the whole innovation cycle. SMEs can apply to phase 1 with a view to applying to phase 2, or directly to phase 2.

The SME instrument is implemented via specific calls. The following SME instrument calls are of interest to SMEs active in the Health and Life Sciences:

• PHC 12: Clinical validation of biomarkers • ICT 37: Open Disruptive Innovation • NMP 25: Accelerating the uptake of

nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs

• BIOTEC 5: SME-boosting biotechnology-based industrial processes driving competitiveness and sustainability

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Fast-track to innovationFast track to innovation (FTI) funds activities to accelerate market introduction of new innovative projects. The innovation can come from any technology field that is a focus area of Horizon 2020. FTI targets technologies, concepts, processes and business models that need a last development step to reach the market and achieve wider deployment.

Marie Curie actionsSMEs are encouraged to participate in Marie Curie actions, such as Innovative Training Networks (ITN) to enhance training, mobility and career development of researchers. The ITN-EID (Innovative Training Networks – European Industrial Doctorate) involves the non-academic sector in doctoral training by allowing doctorate students to perform part of their research in industry.

Collaborative projectsThe strong focus of Horizon 2020 on implementation and exploitation of R&D means that SME involvement in large collaborative research and innovation or innovation actions is highly encouraged. Targeted Work Programmes relevant for the life sciences, medical technology and healthcare industry are:

Health, Demographic Change and Wellbeing aims to create opportunities for real breakthrough research and radical innovation to respond to the ageing population and the increasing burden of communicable and non-communicable diseases.

Leadership in enabling and industrial technologies focuses on new opportunities for industrial leadership in Europe. Within LEIT, two Work Programmes are relevant for Health and Life Sciences: ‘Information and Communication Technologies’ (ICT) and ‘Nanotechnologies, Advanced Materials, Biotechnology and Advanced Manufacturing and Processing’ (NMP & BIOTEC).

Access to risk financeAccess to risk finance aims to leverage private Research & Innovation investments, including venture capital investments for innovative, high-tech companies, in particular SMEs. Horizon 2020 allocates a budget of €2.84 billion for financial instrument facilities and accompanying measures. At least one-third of this amount is likely to be dedicated to SMEs and small mid-caps. Access to risk finance includes a debt facility (providing debt finance) and an equity facility (providing equity investment) and is implemented via the European Investment Bank and the European Investment Fund and/or other financial institutions of comparable stature.

If you would like to receive more detailed information about one of the funding instruments, please contact one of our consultants (page 18)

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ttopstart facilitates strategic preparations for a head start in Horizon 2020Is your organisation or department fully prepared to take the lead (or take part) in Horizon 2020 projects? Are you confident that your projects will get funded? Building on years of experience in the field of European subsidies, ttopstart can rapidly analyse the competitiveness of your organisation in a subsidy context. ttopstart provides you with access to our broad academic and industrial network. Moreover, we can give practical recommendations for optimal preparation for success in Horizon 2020 - even prior to any application. Whilst not guaranteeing success, a head start will definitely increase your chances.

ttopstart is able to write 80% of the total applicationttopstart can write the Horizon 2020 proposal (in close contact with the consortium), allowing you to focus on the scientific work plan. ttopstart manages the entire application process: from writing the body of the proposal, to collecting, streamlining and merging partner input, setting up detailed budget plans, distributing

draft versions, handling partner feedback and final submission. This allows you to spend most of your time on the scientific quality and overall management.

ttopstart supports you with professional non-scientific managementProfessional scientific and non-scientific management is a prerequisite for your Horizon 2020 consortium - and highly appreciated by reviewers. In the application phase, we offer a large toolbox with proven management frameworks and can tailor a model for project management and consortium organisation that secures quality and quantity of the output. In the project phase, we are a strong consortium partner for non-scientific management; from monitoring and reporting deliverables, to organising meetings and drafting progress reports.

Why ttopstart?

ttopstart is a European science and business consulting company with the ability to write 80% of your Horizon 2020 application. ttopstart has unique expertise in supporting you with non-scientific management, dissemination and exploitation activities during the project.

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ttopstart delivers high-quality dissemination and exploitation services for new and existing Horizon 2020 projectsHorizon 2020 was created to boost Europe’s competitiveness and increase scientific leadership. It should be very clear how your Horizon 2020 project will contribute to this goal. ttopstart specialises in developing creative and detailed stakeholder-sensitive plans for dissemination and exploitation of the proposed outcomes. Our experience in developing corporate business plans means that we can integrate a society-targeted vision in your proposal and set up a winning impact section. This becomes of real value once the project has been approved: ttopstart is the ideal dissemination & exploitation partner, ensuring that stakeholders are involved, output is IP protected and commercialised and the proposed impact is achieved.

At ttopstart, we combine science and business, specialising in the fields of life sciences, medical technology and healthcare.ttopstart has been built on the unique combination of science and business, with a focus on the life sciences, medical technology and healthcare sectors. Our consultants have a solid scientific background combined with an extensive business skill set. This is a key advantage for your Horizon 2020 application, considering the increased EC demands for translation of research, public private partnerships and societal impact. Proposals do not leave our office without scientific and business excellence.

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Key achievements

The strong focus and unique model have allowed ttopstart to become highly successful in European and national subsidy applications. Over the past 3 years, more than 70% of our proposals were granted, with multiple #1 rankings and high rankings in competitive European programs such as FP7/Horizon2020, Eurostars and Innovative Medicines Initiative (IMI). Some examples:

Collaborative projectsttopstart has supported over 20 international research consortia, often consisting of academic and industrial partners, with acquiring subsidies for FP7/ Horizon 2020 collaborative projects. BALANCE (AMC) Size: €6M Topic: Artificial Liver

In the BALANCE project, small manufacturing enterprises (SMEs) Hep-Art Medical Devices B.V., Pharmacell and BioPredic International have joined forces with the Academic Medical Center of the University of Amsterdam and the Royal Infirmary of the University of Edinburgh to develop a bioartifical liver.

ttopstart supported the BALANCE consortium with the consortium formation, design of the project plan and proposal writing.

“The translation of innovative drug development ideas into cutting-edge proposals, in combination with their efficient and pleasant way of collaboration, are the reasons why we return to ttopstart every time.” – Cristianne Rijcken PhD, founder Cristal Therapeutics

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Eurostars ttopstart has managed 10 successful Eurostars applications for different SMEs throughout Europe. One of these applications was ranked as #1 out of 354 applications.

Eurostars 2012: SeDI (SOHARD & MAASTRO CLINIC) Size: €1.2MTopic: medical device

SOHARD Software GmbH, an expert company in semantic software development for healthcare, and MAASTRO, a renowned radiotherapy clinic and research institute, join forces to develop a semantic web adapter and a stand-alone PACS system that enables unprecedented ways to access and analyse medical data.ttopstart was highly involved in the SeDI application, from basic concept to final submission. The project was ranked #1 out of 354 applications.

Eurostars 2013: PLATO (ThromboDx)Size: €1.1MTopic: medical device

PLATO aims to develop a non-invasive molecular diagnostic test based on the patented blood platelet technology of ThromboDx. The test will monitor the dynamic mutational status of NSCLC patients for personalised medicine.ttopstart successfully supported the PLATO consortium in acquiring funding from Eurostars to bring their diagnostic test to clinical trials.

"The dedication and writing excellence of ttopstart has been key to the success of the SeDI project." – Peter Feltens, CEO Sohard

"The application of the Eurostars PLATO grant awarded to a consortium led by thromboDx BV was a great success. We are thankful to ttopstart BV for their solid support." – Dr. Thomas Würdinger, CSO thromboDx BV.

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Our method

FitHigh-ranking projects show an ideal fit between proposal and call text. Both consortium and proposal must seamlessly match with the EC's intentions. To optimise this fit, ttopstart assists in: • Finding strong consortium partners -

academic and industrial• Critically assessing and strengthening

your initial project plan

“Through our experience and a devil's advocate attitude we are able to rapidly see whether a proposal idea has winning potential.”

“Our approach is acknowledged for its efficiency and harmony in the consortium.”

FrameworkUniting the visions of 5 - 30 partners into a synchronised and solid proposal is one of the main challenges for constructing a winning bid. ttopstart offers the tools to design a conceptual framework in which the consortium's plans can be integrated and fine-tuned towards a logical work plan. We use the problem analysis and Pyramid Principle in Horizon 2020 style in which we:• Analyse the major problem – focal

problem – sub challenges• Define the ultimate goal – project

objective – sub objectives• Connect work packages and impact to

these items

ttopstart has developed the FFWD model to fast-forward your science from an innovative vision to a winning Horizon 2020 proposal. Because of our risk-bearing strategy, we are highly motivated to succeed. We specialise in impact, for the consortium and for society.

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WriteDeveloping a convincing proposal requires excellent writing skills, which are represented in the ttopstart team. ttopstart ensures a persuasive presentation of the proposal by applying the 8 C's: conform, complete, consistent, concise, concrete, convincing, coherent and creative. ttopstart guards timeliness and coordinates the entire application process - which can be as demanding as the writing part.

DevelopmentCommercialisation, impact, dissemination and exploitation are now a central part of all Horizon 2020 proposals. ttopstart excels at these sections because of our extensive business consulting expertise. ttopstart offers detailed market intelligence and business development strategies to leverage societal and economic impact. During the application phase and the course of the project, ttopstart is your management and impact partner. We offer a variety of (tailored) packages to facilitate productive management, exploitation and dissemination.

“The consortium is asked to deliver the work packages in a draft format. With your scientific input, ttopstart can set up the entire proposal from beginning to end."

“Combining scientific and business expertise in your project results in high impact publications and valuable innovations."

Submission Review EC Negotiation

Knowledge utilisationProject management

Development

Consortium formation

FitConceptualisation of research plan

FrameworkProposal preparation

Write

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ttopstart’s full service support for Horizon 2020 applications includes: • Providing the required templates for proposal drafting and partner input

(administrative, work packages);• Coordinating administrative information gathering;• Coordinating the set-up of a detailed project budget according to EC guidelines;• Coordinating the development and the writing of the project proposal;• Writing the basis of all texts (excluding work packages);• Sending out consecutive proposal draft versions to the consortium for feedback

and processing the feedback;• Optimising texts;• Reviewing the work plan and formulating SMART objectives; • Reviewing the proposal against the official submission and review criteria;• Supporting submission of the proposal;

ttopstart can support the complete application process for a Horizon 2020 proposal. We offer writing capacity and experience, a clear and concise presentation of the project proposal and coordination of the entire application procedure.

Full application support

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General info proposal

Summary

Administrative details participants

Budget per partner

Overall budget

Section 1: Exellence Objectives

Relation to work programme

Concept and approach

Ambition

Section 3: Implementation Work plan

Management structures

Consortium as a whole

Resources to be committed

Section 4: Consortium partners

Section 5: Ethics and Security

Section 2: Impact Objectives

Relation to work programme

ttopstartClient

ttopstart can write 80% of your Horizon 2020 proposal

Part B

Part A

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Submission

ttopstart’s review service follows our successful FFWD method (see page 10) to assess your proposal’s strengths and weaknesses. During three iterations, an experienced consultant will provide clear feedback, with easy-to-implement tips and tricks to elevate your proposal to the next level.

Fit and Frameworkttopstart will cross-check your proposal and consortium against all eligibility rules and the fit to the call text of the corresponding funding scheme. We will assess the innovativeness of the project plan and the coherence of the framework. WriteWith access to over 100 subsidy applications, ttopstart will provide you with ‘best practices’

to present and highlight the strengths of your project plan in an appealing manner. We provide input on how to write a proposal that can convince experts, while remaining interesting and accessible for everyone. Our consultants have excellent writing skills, and will also provide a review on syntax and spelling.

DevelopmentIn the third iteration, ttopstart will focus on the persuasive and broad presentation of impact and dissemination of the project results. We will help you to couple these to key market trends and policies. ttopstart can provide clear-cut examples of how to write a convincing implementation plan that spans beyond the project.

Building on our experience in writing winning subsidy proposals, ttopstart is the ideal partner to extensively review your proposal. We will provide you with a clear and easy-to-implement evaluation which will improve your chances of success.

Review service

F&F W D

∙ Fit the call ∙ Consortium build-up∙ Innovativeness∙ Coherent project plan

∙ Persuasive and accessible∙ SMART goals

∙ Management structure ∙ Broad impact∙ Implementation plan

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Contact us

For more information please contact one of our consultants or visit our website at www.ttopstart.com

Marije aan den Toorn PhD - [email protected]

Patrick de Boer MSc. - partner [email protected]+316 5389 7487

ir Jasper Levink - [email protected]+316 3434 2333

Jochem Bossenbroek MSc. - partner [email protected]+316 2244 2641

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www.ttopstart.nl20

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