Raihaan Khan Nanodiamonds

7/25/2019 Raihaan Khan Nanodiamonds

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Diamond Nanoparticles

Raihaan Khan

University of Illinois atChicago

October 22 201


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Nanodiamonds

!ave e"cellent mechanical and optical properties

!igh s#rface areas

$i%e & nm

Optical properties and '#orescence Non to"ic

(iocompatibility

!igh thermal cond#ctivity and electric resistivity

Chemical stability $everal applications & tribology) dr#g delivery)

bioimaging) and tiss#e engineering) *ller materialfor nano composites+


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!istory

Initially ,ere prod#ced by detonation inthe 1-.0s+/1

In the 1-0s) these diamond started

getting pop#lar to the rest of the ,orld+ any brea3thro#ghs in the 1--0s+

Colloidal s#spension of individ#al particles

4l#orescent NDs #sed for biomedical imaging

Nano scale magnetic sensors #sing NDs

4o#nd to be less to"ic then other carbonnanopaticles


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4ormation

NDs are prod#ced from e"plosives ordetonation+


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Dr#g Delivery


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Dr#g Delivery

D#e to e"cellent biocompatibility) the NDs are being called)5(iomaterial of the 21stcent#ry6

edical diamond coatings are being heavily researched forimplants and prostheses+

ND7embedded device is c#rrently being made to deliver

chemotherapy dr#gs locally to sites ,here cancero#s t#mor hasbeen removed+

Dr+ Dean !o tells Nano,er36 8he nanodiamonds are comple"ed,ith a chemotherape#tic) and s#bse9#ently enable s#stained:slo,release of the dr#g for a minim#m of one month) ,ith a signi*cant

amo#nt of dr#g in reserve+ 8his opens #p the potential for highlylocali%ed dr#g release as a complementary and potent form oftreatment ,ith systemic in;ection to,ards the red#ction ofcontin#o#s dosing) and as s#ch) atten#ation of the often po,erf#lside e


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Dr#g Delivery Design


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=rotein imics

Nds can be #sed to mimic glob#lar proteins+

$mall si%e

$table core

>bility to self assemble ?o, cytoto"icity

Can be #sed to transport other molec#les li3egenetic material across cell#lar membranes+

Use NDs to ma3e arti*cial n#cleosomes) byattaching the s#rface ,ith covalent aminogro#ps) and ,rapping it in DN>+


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Nanocomposites

NDs are e"cellent *ller materials) d#eto it@s great mechanical and thermalproperties) and the rich s#rface

chemistry of the the ND particle+

Chemical stability of the diamondcore) ma3e it s#itable for biomedical

applications+ 5Nanocomposites are a rapidly

gro,ing area in nanodiamond

research+6/1


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Dental *llings

ND have recently been fo#nd tostrengthen dental *llings+ echanically rob#st *lling material

Combined ,ith an antibiotic the *lling cancombat infection that develops in the rootcanal+ >ltho#gh the *ller didn@t *ll the

complete region it needed to be *lled) ithad lo,er rate of infection+ UC?> dentistryteam are doing more research onto thiscomposite to ma3e it an ideal dental

*lling+


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Cancer

A"tensive research is goinginto NDs) and ho, they are#sed to treat cancer+

5(y binding m#ltiple

molec#les of a commonle#3emia dr#g ,ithnanodiamonds) scientistsfrom the NationalUniversity of $ingapore

BNU$ and University ofCalifornia) ?os >ngelesBUC?> managed to boostthe delivery of the dr#g tole#3emic cells and retain

the dr#g ,ithin the cells tocombat the cancer+6


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Refrences

1+ ochalin) adym N+ PUBLISHED ONLINE: 18 DECEMBER2011 | DOI: 10.1038/NNANO.2011.209 The Proer!"e# $%&

A'"($!"o%# o) N$%o&"$*o%Bn+d+E n+ pag+ Feb+

2+ Danilen3o) + + On the history of the discovery of

nanodiamond synthesis+ =hys+ $olid $tate H.) -&--B200H+

+ Jreiner) N+ R+) =hillips) D+ $+) ohnson) + D+ L ol3) 4+Diamonds in detonation soot+ Nat#re ) HH0&HH2 B1-+

H+ (ehler) K+ D+ et al+ Nanodiamond&polymer composite

*bers and coatings+ >C$ Nano ) .&.- B200-+ + Chang) M+ R+ et al+ ass prod#ction and dynamic imaging

of '#orescent nanodiamonds+ Nat#re Nanotech+ ) 2H&2B200+

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Raihaan Khan Nanodiamonds