www.deretil.comDecember 2019

CORPORATE PRESENTATION

From north to south

the Mediterranean

coastline joins

Barcelona and Villaricos,

where Deretil has its

core manufacturing site.

LOCATIONS

December 2019

OUTSTANDING

SITUATION

The strategic layout of the factory, the

financial and commercial office provide us the

right prospect of our present and a great

overview of the future.

Manufacturing site:

Villaricos, Almería, Spain

December 2019

2019

Vill

aricos

HISTORICAL

FACTS

Vill

aricos

1978

1961

1981

1996

1975

1992

1998

Creation of Derivados

del Etilo, S.A.

Active in Bromine

till 1983

Start in side chains

manufacturing (PGCH)

Start-up of Phenylglycine

Base (PG Base)

Start of Parahidroxy

Phenylglycine

Enzymatic production

Line (PHPG)

Deretil was acquired by

DSM. NV

(Dutch multinational

Company)

New Parahidroxy

Phenylglycine plant

(PHPG)

HISTORICAL

FACTS

1998/9

2003

2005

2002

2004

2006

New waste-water

treatment plant

New Products:

Allantoin,

PH Glycol Ester

Purimox® plant

(enzymatic amoxicillin)

New expansion of

PHPG plant

Start of Strategic Plan

2005-2007

Expansion projects and

customer service

HISTORICAL

FACTS

2007

2009

2015

2008

2011-13

2016

FDA approval in Good

Manufacturing

Practices (cGMP)

Management

Buy-out

Introduction of New

Products (custom

manufacturing, etc)

Standard FDA inspection,

Management Priorities and

Customer service

Consolidation of the

Quality Management

System and the business

Standard FDA inspection

2017-18

Implementation of

SAP ERP System2019

Spanish Ministry of

Health approval in cGMP;

Re-Certification ISO 9001:2015

and ISO 14001:2015

April 2017

PRODUCTS

AND

APPLICATIONSSide Chains

(Deretil Products)

Main

Raw

Materials

Benzaldehyde

HCN

Phenol,

Glyoxilic

Acid

Bulk Actives

(Betalactams)

Danfenil®

PGA

Danhidro

PHPG

Danoxi®

SSC

SSP

(6-APA)

(7-ADCA)

(7-ADCA)

Ampicillin

Amoxicillin

(Purimox®)

Cephalexine

Cephaclor

Cephradine

Cephadroxil

December 2019

PRODUCTION

Six industrial plantsThe factory in Villaricos concentrates the global production of

Deretil. The site includes six facilities, where a like number of

products are manufactured.

Parahidroxy Phenylglycine Dane Salt Danoxi®Commercialized since 1990.

D (-) Phenylglycine Dane Salt - Danfenil®Marketed since 1990.

D (-) Parahidroxy Phenylglycine

Two industrial facilities: Since 1992 manufactured

at area 9000 and also at area 10.000 from 1998 onwards.

Purimox®Amoxicillin, an antibiotic produced since 2002.

Pilot Plant / Multi – purpose plantAllantoin

Dihydro Phenylglycine Dane Salt - Danhydro®

Parahidroxy Phenylglycine

Glycol Ester

Phenylglycine Amide

December 2019

TOP PRIORITIES

Ongoing trainingSafety, Health and the Environment Policy encourages our

ongoing training activities. Deretil’s efforts in this area have

Led to maintain workplaces almost injury-free, which have

Been recognised by the Spanish Independent Commission

For Safety and Hygiene in Chemical Industries.

Registered in cGMP by the FDA for API:Purimox®

Certificate of cGMP Compliance by the Spanish

Agency of Health

ISO 9001:2015

ISO 14001:2015

ISO 22716 (Cosmetic cGMP)

December 2019

ORGANIZATION

Management Team

Knowing how to coach means knowing how to entrust. We believe and bet on the human value of

a great team, who keep together and are prepared to continue replying to the society’s needs.

GENERAL MANAGERMr. Antonio Arroyo

FINANCE & CONTROLMr. Ferran Barral

MANUFACTURINGMr. Gracian Gutiérrez

PRODUCTION Almería

COMMERCIALMr. Antonio Arroyo

December 2019

ORGANIZATIONAL CHART

Barcelona Headquarters

General ManagerAntonio Arroyo

Finance & ControlFerran Barral

CommercialAntonio Arroyo

Sales

Cristian

Izquierdo

Purchasing

& Logistics

Gerardo Frontera

Treasurership

Sandra

Izquierdo

Administration

Deputy Manager

Mireia Martin

Controller

Mar Reis

December 2019

ORGANIZATIONAL CHART

Almeria Site

SITE DIRECTOR

G. Gutierrez

QUALITY CONTROL

A. Sánchez-Fresneda

QUALITY ASSURANCE

M. C. Navarro

PERSONNEL &

GENERAL AFFAIRS

R. López

PURCHASING

C. López

PRODUCTION

J.A. Torres

ENGINEERING

E. Cruz

PRODUCTION &

FACILITIES

Plant Managers &

Shift supervisors

A-4000 A-9000 A-10000 A-14000A-15000

PURIMOX ®

SERVICES:

Legal, Medical,+

Administration,

Vigilance, etc.

LOGISTICS

B. Gonzalez

A-6000

A-8000

SAFETY, HEALTH &

ENVIRONMENT

F.J. Martínez

DERETIL VITATECH

R&D

M. Santiandreu

December 2019

MAINTENANCE

A. Alonso

PEOPLE AND

TECHNOLOGY

TOGETHER WE MAKE

DERETIL INJURY-FREE

Motivation and quality of our staffFundamental for our goals achiviement.

Essential

Direct involvement of our employees in the

process of optimizing operations and the way

to learn from each other.

Staff evolution 2018:

- Barcelona ………. 16 employees

- Almeria …………. 182 employees

TOTAL ………….. 198 employees

December 2019

PEOPLE AND

TECHNOLOGY DERETIL, S.A. operates 24 hours a

day, 7 days a week in three shifts.

The shift breakdown is:

Shift 1 = 6.00 am through 2.00 pm

Shift 2 = 2.00 pm through 10:00 pm

Shift 3 = 10:00 pm through 6:00 am

December 2019

SITE LAND

PROPERTY – TOTAL ……. 77 hec.

- Total industrial soil ……… 36 hec.

- Total rustic land …………. 33 hec.

- Other applications ………. 8 hec.

December 2019

Manufacturing

Installations

The factory is a self-sufficient site

provided with all necessary facilities

and services:

Electricity Cogeneration

Plant

Steam

Water

Sea water

N2 production

Air

Brine

WWTP

Warehouses

December 2019

LEGAL NAME

AND ADDRESSES

December 2019

Office:

Deretil, S.A.

Calle La Llacuna, 161, 2º

08018 Barcelona (Spain)

Tel. +34 93 467 71 17

Fax +34 93 467 71 31

Factory:

Deretil, S.A.

Villaricos, s/nº

04616 Cuevas del Almanzora

(Almeria, Spain)

Tel. +34 950 618 000

Fax +34 950 467 401

www.deretil.com

www.deretil.comDecember 2019

LIFE CHAIN