EditorialOxidative Stress in Disease and Aging: Mechanisms andTherapies 2018

Claudio Cabello-Verrugio ,1 Cristian Vilos,1 Raquel Rodrigues-Diez ,2

and Lisbell Estrada3

1Universidad Andres Bello, Santiago, Chile2Universidad Autónoma de Madrid, Spain3Universidad Bernardo O’Higgins, Santiago, Chile

Correspondence should be addressed to Claudio Cabello-Verrugio; claudio.cabello@unab.cl

Received 29 July 2018; Accepted 29 July 2018; Published 23 September 2018

Copyright © 2018 Claudio Cabello-Verrugio et al. This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original workis properly cited.

Among the key factors influencing human health are thechronic diseases and aging, which have been increasing inthe last decades. These pathological states are produced byseveral and diverse causes, and a common factor involvedin most of them is oxidative stress. Cellular oxidative stressis defined as an imbalance between oxidative status, mainlyby the formation of reactive oxygen species (ROS), andantioxidant defense mechanisms. Due to the broad and pro-found biological effects of ROS, in the last years, numerousexperimental and clinical studies have focused their attentionon the participation of oxidative stress as a key regulatorin chronic pathological status and aging. Regarding thisrelationship, the aim of many ongoing studies is to elucidatethe underlying mechanisms and role of oxidative stress indisease onset and development. In particular, there is anemphasis on finding new therapeutic strategies for chronicdiseases and aging by decreasing oxidative stress.

This versionof the annual special issue of “Oxidative Stressin Disease and Aging: Mechanisms and Therapies 2018” pre-sents novel and relevant research regarding the mechanismsby which oxidative stress induces damage in the contexts ofdiseases and aging. Focus is given to the use of novel antioxi-dant strategies. The manuscripts within this special issue areall equally recommended by the editors, but the followingcontain especially interesting points worth comment.

G. Rowicka et al. evaluated the intensity of oxidative pro-cesses and the efficiency of antioxidant defense in children

with celiac disease. The results do not shown differences;however, they demonstrated that the strict adherence to agluten-free diet by children with celiac disease seems to beimportant for maintaining oxidative-antioxidant balance.

J. Ábrigo et al. shown a review of the mechanismsinvolved in the development of cachexia and their close rela-tion and fine regulation of oxidative stress. The wide vision ofthe process and how oxidative stress is a key factor that can betargeted to treat the muscular dysfunction secondary tochronic diseases and aging are clearly presented in this review.

W. B. Jang et al. developed a novel antioxidant molecule,a novel antioxidant defined as MHY-1684, and studied itseffect on the therapeutical effect of resident cardiac progeni-tor cells (CPCs) in diabetic cardiomyopathy. The authorsdemonstrated that the treatment with MHY-1684 may affectthe activation and inhibition of mitochondrial dynamics-related signaling and mitochondrial function in response toROS stress. In addition, the data allow concluding that thenovel compound MHY-1684 acts as an ROS scavenger andmight provide an effective therapeutic strategy for CPC-based cell therapy against diabetic cardiomyopathy.

C. He et al. investigated the effect of the antioxidant edar-avone on the cardiac dysfunction during sepsis. The studyshowed that in a rat model of septic myocardial dysfunction,edaravone suppressed oxidative stress and protected theheart against septic myocardial injury and dysfunctionthrough the induction of the HIF-1α/HO-1 pathway.

HindawiOxidative Medicine and Cellular LongevityVolume 2018, Article ID 2835189, 2 pageshttps://doi.org/10.1155/2018/2835189

All of these highlighted studies, as well as the othermanuscripts contained in this special issue, advanceimprovements on pathological statuses by using diverseantioxidant strategies. We firmly believe that these findingswill be of relevance to research concerning OS, chronicdiseases, and aging.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Acknowledgments

The editors thank all of the authors who submitted theirresearch to this special issue. The editors also thank eachreviewer for their valuable contributions. The lead guesteditor thanks all of the collaborating guest editors for theircritical and exhaustive reviews and support, which werecritical for the successful publication of this special issue.

Claudio Cabello-VerrugioCristian Vilos

Raquel Rodrigues-DiezLisbell Estrada

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