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3/26/2012
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Oxidative Stress + Aging
• Denman Harmen 1950’s
“Organisms age because cells accumulate free radical damage with the passage of time”
- rate of living theory- hyperbaric hyperoxia and radiation both damage by free radicals
Rusting – oxidation of metals…..……… “aging oxidation of humans?”
Smith and Reid. Respiratory Physiology & Neurobiology 151 229244, 2005
Free radicals in vivo:
OUTLINE:
• Background- oxidative stress and aging- aging and exercise
• Free radicals…. from muscle or blood?• Vascular function, oxidative stress,
exercise and antioxidants• Conclusions
• “twist(s) in the tale”
3/26/2012
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0.000
0.050
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0.350
0.400
Rest Exercise
YOUNG (n = 6)
AGED (n = 6)
Group and Condition effects
UQ
( A
U /
g
P )
20G
220mg
201mg
163mg
128mg
A
Ba ley et al 2010
0
50
100
150
200
250
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Rest Exercise
YOUNG (n = 6)
AGED (n = 6)A
10G
LO
- L
C
( A
U /
mg
tis
sue
mas
s
)
Group and Condition effectsInteraction effect
† *
†*
92mg
76mg
86mg
78mg
Ba ley et al 2010
0.000
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Rest Exercise
YOUNG (n = 6)
AGED (n = 6)
LO
OH
(nm
ol /
mg
P
)
Group and Condition effects
A
Ba ley et al 2010
