Outcomes post cardiac surgery in patients treated with fenoldopam vs dopamine

Bove T et al Circulation 2005; 111:3230-3235.

End point Fenoldopam, n (%)

Dopamine, n (%)

p

Acute renal failure (25% increase in serum creatinine from baseline)

17 (42.5) 16 (40) 0.9

Renal replacement therapy

4 (10) 4 (10) 0.9

Death 4 (10) 3 (7.5) 0.5

Tumlin JA et al. Am J Kidney Dis 2005; 46:26-34. .

Outcomes with fenoldopam vs placebo in patients with acute tubular necrosisEnd point Fenoldopam,

n (%) Placebo, n (%)

p

Dialysis therapy and/or death at 21 days

22 (27.5) 29 (38.7) 0.235

Dialysis therapy 13 (16.25) 19 (25.3) 0.163

Death at 21 days (%) 13.8 25.3 0.068