Microsystems for biomedical and environmental applications

MicrofluidicsPart III: Commercial examples

Prof. Dr.-Ing. S. GaßmannSevilla 2018

Commercial microfluidic examples

- Abott I-stat - first blood gas analyzer- Edan 15 – yet another blood gas analyzer (nice video:

https://www.youtube.com/watch?v=o8W331MmMw0)

- Picollo Xpress – blood tests on a disk(https://www.abaxis.com/medical/piccolo-xpress)

- Roche Cobas Liat – DNA Analysis in a tube(https://diagnostics.roche.com/global/en/products/systems/cobas-liat-system.html)

- Bosch Vivalytics – platform for molecular diagnastics(https://www.bosch-vivalytic.com/en.html)

- Medimate Minilab – electrophoresis used for Lithium detection (www.medimate.com)

- Nutrient analyzer for oceanography (6 monthautonomy, 6000m depth)

2 von <8> Prof. Dr. Ing. Gaßmann FMEMS Summer School 2018

Point-Of-Care Analyzer (Bsp: I-Stat Abbott)

System for blood gases and electrolytes

Modular system– Handheld device– Data evaluation (download calibration data)– Microfluidic cartridge

detector: MEMS Biosensors– Amperometric, Potentiometric, Konduktometric

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Point-Of-Care Analyzer (I-Stat Abbott)

usage:fill the sample close insert and wait

External calibration (once a day)!Electric stimulator

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Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 6 von <8> Mikrofluidische Anwendungen

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Centrifugal platforms

Forces:• Centrifugal force:

Fc = −mω × (ω × r)• Coriolis force

Euler Force

Pressure over a liquid column

Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 15 von <8> Mikrofluidische Anwendungen

Fc = −mω × (ω × r)

Piccolo Xpressblood chemistry and electrolyte analyzer

• Principle: centrifugal forces• All tasks are performed on the

disc• Detection by absorption

measurement• Many discs with different tests

and combinations available(even veterinarianapplication!)

Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 16 von <8> Mikrofluidische Anwendungen

Lithiumtest by electrophoresis

Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 19 von <8> Mikrofluidische Anwendungen

• Detecting Lithium by electrophoresis• Disposable Chip with all integrated reagents• Reader for measurement

• Spinoff made by students of U Twente

teststrip reader

Medimate Minilab principle

Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 20 von <8> Mikrofluidische Anwendungen

Source: www.medimate.com

Nutrient Analyzer for Oceanography

National Oceanography Centre SouthamptonOCEAN TECHNOLOGY AND ENGINEERING GROUPHead: Matt Mowlem

- development of lab-on-chip systems for oceanography- several analytes- long term deployment test- commercialization by technology transfer

Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 21 von <8> Mikrofluidische Anwendungen

Phosphate Analyzer

• Grand Maxime et.al “A Lab-On-Chip Phosphate Analyzer for Long-term In Situ Monitoring at Fixed Observatories: Optimization and Performance Evaluation in Estuarine and Oligotrophic Coastal Waters”,Frontiers in Marine Science, Vol. 4, 2017 URL=https://www.frontiersin.org/article/10.3389/fmars.2017.00255

Microfluidics - Prof. Dr. Ing. Gassmann 22 von <8>