Kelompok 2 SENSITIVITAS AB 2.ppt

8/18/2019 Kelompok 2 SENSITIVITAS AB 2.ppt

http://slidepdf.com/reader/full/kelompok-2-sensitivitas-ab-2ppt 1/23





ALUR PENELITIAN

PENYAKIT

ANTIBIOTIK

RESISTEN

SENSITIF

INTERMEDIET PENGUJIAN



DEFENISI

SENSITIV !"# $%!&' *+' %&*'*+, %-*&!*&$& &'$ *+'

-%/&*+ &-"'%-#!/ -&&&' %%-* -%/&%- %/' !& $'.

INTERMEDIET !"#$%!& !* &'&'**'*$ !#

'*!$ %&*'*+ &&%" %&"*-%*'%&*.

RESISTENSI !"#$%'#&& '

*$--&*%'%-#!/ ' &'*

*$- ' &'**'*$'%-'%&'.



Penggolonganantibiotik

1. %-!-$& /%$'- $'**'

2.%-!-$& '-$'- $**

3.%-!-$& %$&*% $%-6



Penggolongan antibiotik berdasarkan atasspektrum aktivitas dapat dibagi atasbeberapa golongan7

• A&'**'*$ !%&& /%$'- ", %+%$'*+ *$'%-#!/ - /*'*+ /& - &%'*+.8&'#& 7 '%'-*$"*&, '-&& +%&*$",

'-&&, '-&& *&"*$*!, '-&&$-"*!, -*+/**&, %%-/ '-&& /%&**""*&(/**"*&, $**"*&, %$/**&, $-%&**"*&,#%'*"*&, !& %*& %- '-&& %+"/-*&

• A&'**'*$ & $'**'& "%*# !*&&'%-#!/ $'%-* - /*'*+. 8&'#&7*'-*&, %-*'-**&, %*& %- '-&&/%&**"*&, %/%-'* %&:*" /%&**""*&, $"$*"*&,/%&**"*& G /-$*& !& %%-/ '-&&

%+"/-*&.



• A&'**'*$ & $'**'& "%*# !*&&

'%-#!/ $'%-* - &%'*+. 8&'#&7$"*'*&, /"**$*& "+' !& "+**&

• A&'**'*$ & $'**'& "%*# !*&&/! mycobacteriae. 8&'#&7

'%-/'**&,$%&**&, *$"%-*&, !&***&.

• A&'**'*$ & $'*+ '%-#!/ 6-.8&'#&7 -*+"*&, &'**'*$ /"*%&,

(&*''*&, +'%-**& )• A&'**'*$ & $'*+ '%-#!/ &%/"

(&'*$&$%-). 8&'# 7 $'*&**&, !&"%**&.



Berdasarkan struktur kimiaantibiotik, aitu!

• A&'**'*$ %'"$'( '-&& /%&**"*&,%+"/-*&, !& ; "$' && $"*$)

• T-&& +%&*$"

• T-&& '%'-*$"*&

• A*&"*$*!

• A&'**'*$ $-"*!

• A&'**'*$ /"*/%/'*!

• A&'**'*$ "*&$*!• A&'**'*$ /"*%&

• A&'**'*$ &**&

• A&'**'*$ &'-*$"*&.



P! /%&&& &'**$-

$#& &'**'*$ %-*&%&*"$& $%"& !" '%-/*.A! 2 +$'- & %-/%&-#'%-#!/ $%!& '%-%' &'- "*&

!"# 7

• R%*'%&*& *$--&*%'%-#!/ ' &'**$- '

&'**'*$ & !*&$&.• T%-6!*& /%-*&+%$*



RESISTENSI

• $'%-* !*$'$& -%*'%& '%-#!/&'**'*$ 6*$ $!- $*" &'**'*$'%-%', & !/' !*'"%-&* "%# *&&,'*!$ %&#%&'*$& /%-'#&&.

• %%-/ -&*% -%*'%& %- '-&<'%-& '%-#!/ &'**'*$. M*"&-&*% - &%'*+ -%*'%& '-&<'%-& '%-#!/ &*&.

• P! & -&*% & -%*'%&%&"* /%-#& %&%'*$ $-(-%*'%& $-") ' %$'- $-(-%*'%& %$'-$-") & !**$'*/-% %"%$*.



MEKANISME

RESISTEN



• M'* /&'& DNA

P%-#& $- !/' '%-6!*!%&& - *&%-*, !%"%*, '

'*'* '="%*# &$"%'*! !"%&. J*$ %" %-'#& #*!/ $&%&%$& MO '%-%' %&6!*-%*'%& #$& ! 6 &%&#*"$& -&*% %-/-"*+%-* !* ># '%$&& %"%$'*+.8&'#, Mycobacterium tuberclosis &-%*'%& '%-#!/ rifampin $%'*$!*&$& %* &'**'*$ '&".

P%-#& %&%'*$/%&% -%*'%&*

'



• T-&+%- DNA -%*'%&* 'R%*'%&* %-" !-* '-&+%- DNA

!-* ' $'%-* $% $'%-* "*&.

S%*& %- %& -%*'%&*

!*/%-&'-* /"*!, & !/'

%$* %" %""* /-%

'-&!$* (/%-&'- +%),

'-&+-* ' $&6*.



P%-#& %$/-%* /-'%*&/! -&*% & -%*'%&'

1. M!*?$* "$* '-%'

M*"&7

< -%*'%&* S.pneumoniae '%-#!/&'**'*$ β<"$' %"*'$& /%-#&/! '="%*# /-'%*& /%&*$'</%&**""*&$'%-* ', %&$*'$& /%&-&&

/%&*$'& &'**'*$ /! '-%'&. < P%-#& %&:* /! '-%', DNA

*-%, '%"# %&$*'$& -%*'%&*'%-#!/ @-*&"&%.



2. P%&-&& $"*

. A$*' /%&-&& /%-%*"*'E&'%-'%- &' -%*'%& '%-#!/%+"/-*& !%&& %&#*"$& β<"$'%. N&, -&*% -%*'%& 6/' %*"*$* $&" /-*& & '%"# %-#& '*!$ !/' !*""* %+"/-*&.

. P%&-&& "*-& $%"-

T%'-"*&% %+%$'*+ %">& *&+%$*

*&%$"* $*' %'%-*!% '%'/*%$-&, -&*% *&* -%*'%& $-%&!& /-'%*& & !*/%-&'-* /"*!& %* "*-& $%"- '.



3. I&$'** %&:*'*$

K%/& &'$ %&#&-$& '%&*&$'*+$& %& &'**$- 6 !/'%&$*'$& -%*'%&* '%-#!/ MO.8&'#7

< β<"$'% (/%&**""*&%) & %-#*!-"*'*$ %&*&$'*+$& *&*& β<"$'/%&**""*&, %/"/-*&, !& ' '%-$*'.

< A%'*"'-&+%-% & %&'-&+%-

%'*" /! &'**'*$, %&*&$'*+$&$"-+%&*$"=*&"*$*!

< E'%-% & %&#*!-"** *&*& "'&%$-"*!.



DAFTAR PUSTAKA• H-%, R, A., P%", 8, 8., 2014,

Farmakologi Ulasan Bergambar ,

P%&%-*' $ K%!$'%-& EG8, J$-'.

• D6*!%,



Pertanyaan ???

1. A/ & !*$! !-* %%-/*$--&*% %- '-&<'%-&-%*'%& '%-#!/ &'**'*$ B (W*>*150201303C3)

2. *& - &'$ %&%# '%-6!*&-%*'%&* B(H-& 150201301C)

3. J%"$& #&& &'- /-% '%-6!*&-%*'%&* !& !%%&*'**B(Y-?"15020130155)

4. K%&/ DNA $*-% '*!$ !*$$& !"

*&$'** %&:*B(S-&* #''15020130191)

5. A/ & %&%$& *&'%-%!*%' '%-6!*!& /$# *&'%-%!*%' * %&6!*-%*'%&B (F'#" $#- 15020130192)



TERIM" #"SI$



Pertanyaan

1. Apa ma!"# #ar$ %e%erapa m$r&&r'an$!me re!$!ten

ter(a#ap ant$%$&t$) !e)ara t"r"n men"r"n ? (Wiwik;

15020130373)

*. Ba'a$mana )ara "nt" men)e'a( ter+a#$nya re!$!ten!$ ?

(Harsan; 15020130178)

,. Je-a!an ("%"n'an pr&!e! ter+a#$nya re!$!ten!$ ter(a#ap

#e!en!$t$!a!$ (Ysrafil; 15020130155)

/. Kenapa DNA '$ra!e t$#a #$ ma!"an #a-am $nat$0a!$

en$m ? (Sumarni; 15020130191)

2. Apa yan' menye%a%an $nterme#$et ter+a#$3 #an apaa(

$nterme#$et %$!a men+a#$ re!$!ten! ? (Fathul; 15020130192)



1. Ma!"#nya ya$t"3 apa%$-a m$r&&r'an$!me

re!$!ten3 enta( $t" men'a-am$ m"ta!$3 per"%a(an3

p&&nya yan' men'a-am$ re!$!ten3 pa#a !aat

men'a-am$ re-$a!$ ata" perem%an'%$aannyanant$ et"r"nannya aan men'$"t$ !$4at #ar$

$n#"nya. Ja#$ !$4at re!$!ten!$nya aan t"r"n

tem"r"n (Yunitasari, 1502013019)

*. 5ara pen)e'a(an re!$!ten!$617 M$n"m ant$%$&t$ !e)ara terat"r !e!"a$ #en'an

yan' #$re!epan &-e( #&ter.

*7 8$n#ar$ men''"naan ant$%$&t$ "nt" 4-"3

%r&n$t$!3 %at" p$-e3 !a$t ten''&r&an yan't$#a mera#an' tanpa &n!"-ta!$ #en'an

#&ter ata"p"n ap&teer. (Sinta !usumawati,

15020130158)



,. Re!$!ten!$ a#a-a( eta(anan !"at"

m$r&&r'an$!me ter(a#ap !"at" ant$%$&t$.

Se#an'an #e!en!$t$!a!$ a#a-a( !"at" "!a(a

"nt" men'"ran'$ ata" men'($-an'an ata"memperena-an !e)ara %erta(ap !t$m"-"! ata"

a-er'en pa#a t"%"(. Ja#$3 !e%enarnya yan'

#$ma!"# #en'an pen"r"nan e4e &%at pa#a

pemaa$an +an'a pan+an' #$!e%"t t&-eran!$

&%at3 %"an #e!en!$t$!a!$. ("urhi#rah,

1502013033)

/. DNA '$ra!e t$#a #$ma!"an #a-am $nat$0a!$

en$m arena pa#a #a-am (a- $n$ DNA '$ra!e

t$#a men'a-am$ $nat$0a!$ en$m aan tetap$

(anya men'a-am$ m&#$4$a!$ -&a!$ tar'et en$m.

("urhi#rah, 1502013033)



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Kelompok 2 SENSITIVITAS AB 2.ppt