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ISSX President’s Message
Volume 34 Issue 4, 2014
2014 has been a good year for ISSX. The Society held two successful scientific meetings, our financial position is strong, and planning for future meetings and several new initiatives is well advanced.
As I indicated in a previous issue of the Newsletter, the 5th Asia Pacific Meeting, which was held in Tianjin, China had 550 participants and approximately 300 poster presentations. The meeting was hosted by our affiliate partner, the Chinese Society for the Study of Xenobiotics (CSSX). The joint 19th North American ISSX / 29th JSSX Meeting, held from October 19–23 in San Francisco, was also an outstanding success. Like our previous joint meeting with JSSX in Maui in 2005, there were over 1,100 attendees and more than 600 abstracts. The standard of the scientific presentations and posters was excellent, and the meeting was well-supported by exhibitors. Drs. Tetsuya Terasaki and Eric Johnson, the meeting co-chairs, and their colleagues on the Meeting Organizing
Committee, are to be congratulated for their efforts on behalf of ISSX and JSSX and for delivering such a high quality conference. Given the success of our two previous joint meetings with JSSX, our two Societies have agreed to hold another joint meeting in 2020.
Two meetings are scheduled for 2015. The 13th European ISSX Meeting will be held in Glasgow from June 22–25. The call for abstracts for this meeting is now open and the scientific program is available on the ISSX website. The 20th North American ISSX Meeting will be held in Orlando from October 18-22. Two scientific awards will be presented at each of these meetings. The ISSX Awards Program recognizes the scientific and service achievements of our members. Nominations are currently being accepted for awards that will be presented in Glasgow: the European New Investigator Award (in honor of Karl J. Netter) and the European Scientific Achievement Award. Members are urged to nominate colleagues who may
be eligible for these awards – details on the nomination process are available on the ISSX website.
ISSX will sponsor the participation of four speakers to attend the Drug Metabolism and Pharmacokinetics Symposium at the National Institute of Pharmaceutical Education and Research (NIPER) to be held in Mohali, India in February 2015. Our formal participation in the NIPER Symposium follows negotiations initiated by past-President Bill Smith. ISSX involvement in India is consistent with key objectives of the Society’s Strategic Plan: increasing internationalization, expanding scientific outreach, and growing membership.
Like many organizations, both for profit and non-profit, the Society’s financial position weakened with
By John O. Miners, ISSX President
Continued on page 4
ISSX President’s Message
Book Review: Statistical Methods for Evaluating Safety in Medical Product Development
19th North American ISSX / 29th JSSX Meeting Review
Welcome New Members
Save the Date: 13th European ISSX Meeting
IN THIS ISSUE
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STATISTICAL METHODS FOR EVALUATING SAFETY IN MEDICAL PRODUCT DEVELOPMENTEditor: A. Lawrence GouldJohn Wiley and Sons.400pp, ISBN 13: 978-1-119-97966-1, 2014
“Lies, damned lies and statistics” (late 19th century quotation). Having offended, probably but unintentionally, half of the readership of this newsletter with above adage, an explanation is required. Slightly out of context, these words here are meant to indicate that without the correct and sagacious application of statistics potentially erroneous conclusions may be drawn which, to all intent and purpose except under close scrutiny, appear sound. It is essential that appropriate tests be applied under suitable and acceptable circumstances for meaningful results to be obtained, and that these results are always considered within the constraints and context of the system from which they were derived.
This book is a new member of the “Statistics in Practice” series, a set of mathematical texts that offer detailed explanation and coverage of statistical concepts, describe the relevant methodology, and guide the reader through the use of worked case examples. They are invaluable reference books for those working within a defined field. This particular volume addresses the “challenging
issues of the design, execution, and management of clinical trials,” describing in clear terms the application of statistical methods to safety evaluation during the various stages of product development, through the clinical domain and beyond into the medical world at large.
Fifteen authors have constructed fourteen chapters, six written solely by the editor. Following an introductory segment the chapter titles are: Safety graphics; QSAR modelling: Prediction of biological activity from chemical structure; Ethical and practical issues in Phase I trials in healthy volunteers; Phase I trials; Summarizing adverse event risk; Statistical analysis of recurrent adverse events; Cardiovascular toxicity, especially QT/QTc prolongation; Hepatic toxicity; Neurotoxicity; Safety monitoring; Sequential testing for safety evaluation; Evaluation of post-marketing safety using spontaneous reporting databases; Pharmacovigilance using observational/longitudinal databases and web-based information.
Toxicity aspects are focussed on the liver, nervous, and cardiovascular systems, particularly the heart. This is not surprising, as for the past decade or so drug regulators have recommended/required that all compounds be evaluated for their effects upon the QT interval and
potential arrhythmic consequences. The text is complemented by the inclusion of comprehensive references to the relevant medical literature (as well as insights into SAS and R codes [computer statistic programming languages]) and, as usual, the physical construction of the volume is excellent. Highly recommended for all those who work within, or are about to enter into, this fascinating world of drug development and associated areas. A worthwhile tome for every bookshelf.
Reviewed bySteve MitchellFaculty of MedicineImperial College LondonLondon SW7 2AZ, UK
Book ordering informationJohn Wiley and SonsCorporate Headquarters111 River StreetHoboken, NJ 07030-5774United States of AmericaTelephone: 201.748.6000Facsimile: 201.748.6088Email: [email protected]
The AtriumSouthern Gate, ChichesterWest Sussex PO19 8SQEnglandTelephone: 44.1243.779777Facsimile: 44.1243.775878Email: [email protected]
Book Review
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ISSX 2015 MEMBERSHIP
Support ISSX! Renew with ISSX for the 2015 Membership term and save on your meeting registration for the 13th European ISSX Meeting and the
20th North American Meeting in 2015! www.issx.org/renew.
19th North American ISSX / 29th JSSX Meeting ReviewOn October 19, 2014, academic researchers, industry scientists, and students gathered in San Francisco, California, USA for the 19th North American ISSX / 29th JSSX Meeting. Meeting Organizing Committee Chairs, Tetsuya Terasaki, Ph.D. of the Tohoku University and Eric Johnson, Ph.D. of the Scripps Research Institute and their Meeting Organizing Committee created an outstanding program addressing a broad variety of topics in the science of xenobiotics. This meeting hosted more than 1,150 scientists from 34 nations including India, Japan, and the Republic of Korea.
Three hundred and eighty-four meeting registrants arrived early to attend short courses on Sunday, October 19. The courses covered a variety of topics including the prediction of drug-drug interactions and regulatory recommendations, metabolite biosynthesis and quantitation by NMR spectros-copy, non-CYP metabolism in drug discovery, and the use of DMPK and drug-drug interaction data. The meeting officially commenced with the Opening Welcome remarks from JSSX President, Dr. Kan Chiba, ISSX President, Dr. John Miners, the meeting co-chairs, and Meeting Dedicatee, Dr. Yuichi Sugiyama.
The scientific meeting began with two plenary lectures. “Mechanistic Modeling of Bile Acid-mediated Drug-induced Liver Injury” was presented by Dr. Kim Brouwer of the University of North Carolina, Chapel Hill and “Contributions of the Human Gut Microbiome to Drug Metabolism” was presented by Dr. Peter Turnbaugh of the University of California San Francisco. Following these captivating lectures, attendees met in the exhibit hall for the Opening Welcome Reception to see colleagues and friends, and to spend time with over 60 companies exhibiting their products and services at the meeting.
On Tuesday, October 21, ISSX presented the 2014 ISSX North American Scientific Achievement Award in Honor of Ronald W. Estabrook and sponsored by XenoTech. This year’s award recipient was Thomas A. Baillie, Ph.D. The 2014 ISSX North American Young Investigator Award, in Honor of James R. Gillette, was also presented to Nina Isoherranen, Ph.D. Both Dr. Baillie and Dr. Isoherranen presented lectures after receiving their awards at the podium.
On Wednesday, October 22, JSSX presented the 2014 JSSX Award to Hiroshi Yamazaki, Ph.D. The 2014 JSSX Award for Young Industrial Scientists was presented
to Shintaro Nakayama, Ph.D. JSSX additionally presented the 2014 JSSX Award for Young Scientists to Hiroshi Watanabe, Ph.D., and Satomi Onoue, Ph.D. Each of these awardees presented a lecture to the audience. The 2014 JSSX Award for Young Industrial Scientists was presented to Hiroshi Kodaira, Ph.D. and to Takafumi Akabane, Ph.D.
A new feature of this meeting allowed for the six pre-doctoral and six post-doctoral abstract poster award competition finalists to present brief podium lectures on their research and to take questions from the audience.
Left to Right: ISSX President, John Miners, Meeting Co-Chair, Eric Johnson, Meeting Co-Chair, Tetsuya Terasaki, and JSSX President, Kan Chiba pose for a photo.
Tom Baillie receives the 2014 ISSX North American Scientific Achievement Award in Honor of Ronald W. Estabrook and sponsored by XenoTech from ISSX Awards Committee Chair, Geoff Tucker.
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Continued on page 7
President’s MessageContinued from page 1
the global financial crisis. We have experienced fiscal years during which expenses were greater than revenues; however, the Society’s total net assets have consistently exceeded total operating expenses. Thanks to prudent financial management by successive Councils and the ISSX Office I am pleased to report steadily increasing net assets in recent years. Total net assets at the end of 2014 are projected to be close to $1.9 million. Of this amount, about one-third is restricted funds associated with the ISSX Awards Program. The remainder is for the purpose of maintaining a reserve fund for the protection of the Society and for the development of strategic initiatives intended to provide benefits to the membership.
Finally, to ISSX members and their families: season’s greetings and best wishes for a happy, productive and prosperous New Year from ISSX Council and the ISSX Office.
John O. Miners President International Society for the Study of Xenobiotics
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PLEASE JOIN ISSX at the
FOLLOWING UPCOMING MEETINGS
13th European ISSX MeetingUniversity of StrathclydeGlasgow, Scotland, UK
June 22–25, 2015Meeting Chairs: Roland Wolf, Ph.D.
& Ann Daly, Ph.D.
20th North American ISSX MeetingHilton Orlando Bonnet Creek
Orlando, Florida, USAOctober 17–21, 2015
Meeting Chairs: Hartmut Derendorf, Ph.D. & Stephan Schmidt, Ph.D.
11th International ISSX MeetingBusan Exhibition and Convention Center
Busan, KoreaJune 12–16, 2016
Meeting Chair: Jae-Gook Shin, Ph.D.
Throughout the five-day meeting, lectures on a variety of stimulating topics were delivered in parallel symposia which each included invited speakers as well as abstract authors selected to give short presentations from their abstracts. Evaluation data collected as of the writing of this report indicates highly favorable assessment of the scientific sessions with 93 percent of responders rating the sessions as essential and useful.
The meeting included an optional event aboard the yacht, The San Francisco Spirit. Participants enjoyed a dinner buffet and a three hour cruise through San Francisco Bay featuring Alcatraz Island, the Golden Gate Bridge, the art deco Coit Tower, the iconic Transamerica Building, and much more.
ISSX is grateful to Dr. Terasaki and Dr. Johnson, the 19th North American ISSX / 29th JSSX Meeting Organizing Committee, JSSX, the Poster Awards Committee, and all of the session chairs and speakers for their contributions to this successful meeting. The attendees, poster presenters, and exhibiting companies are an integral component of ISSX meetings and we appreciate their participation and support.
This meeting was also sustained by the Industry-Supported Symposia presented by Thermo Scientific, Bioreclamation IVT, Heptregen Corporation, HTG Molecular Diagnostics, Corning, Life Technologies, Quotient Bioresearch, and Quotient Clinical.
Nina Isoherranen receives the 2014 ISSX North American New Investigator Award, in Honor of James R. Gillette from ISSX Awards Committee Chair, Geoff Tucker.
Meeting Dedicatee, Yuichi Sugiyama receives a special gift from ISSX President, John Miners and JSSX President, Kan Chiba.
Continued on next pageThe lights of the Bay Bridge sparkle in this view from the San Francisco Spirit dinner cruise event.
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Thank you to our 19th North American ISSX/29th JSSX Meeting
Sponsors for their Generous Support:
GileadTriangle Research Labs
XenoTech, LLCSigma Life Science
Affymetrix, Inc.InSphero, Inc.
Life TechnologiesMicroconstants
Optivia BiotechnologyQuintiles
Sekisui Medical Co., Ltd.Solvo BiotechnologyWaters Corporation
GenentechCorning
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Left to Right: Poster Awards Competition Committee Member and Award Presenter, Natalie Hosea; Finalists, Chunxue Wang, Xuan Zhang, Miaoran Ning, Nicole Zane, Yuu Miyauchi, Li Wang, Shigeru Ogaki, Yun-Chen Tien, James Chun Yip Chan, Lian Yee Yip; ISSX President, John Miners; Poster Awards Competition Committee Member and Award Presenter, Xiaobo Zhong.
ISSX and JSSX encourage high-quality research and recognize distinguished poster presentations by young scientists in both the predoctoral and postdoctoral categories at the meeting.
All posters accepted as finalists in the competition were reviewed and rated by the Poster Awards Committee on the basis of Significance of Research Problem; Experimental Approach; Soundness of Conclusions; and Clarity of Presentation. The Poster Awards Competition Committee members were Kan Chiba, Chiba University;Maria Almira Correia, UCSF; Natalie Hosea, Pfizer Inc.; Takashi Izumi, Daiichi Sankyo Co., Ltd.; Scott Obach, Pfizer Inc.; Paul Ortiz de Montellano, UCSF; Peter Swaan, University of Maryland; Ikumi Tamai, Kanazawa University; Hiroshi Yamazaki, Showa Pharmaceutical University; and Xiaobo Zhong, University of Connecticut.
Poster Awards Competition Committee Members Natalie Hosea and Xiaobo Zhong announced the awards to pre-doctoral and post-doctoral finalists for best poster presentation in those categories. The winners each received a plaque and an honorarium. The award recipients were:
PRE-DOCTORAL AWARDS:Third Place: Yuu Miyauchi, from the Kyushu University, for the poster A1 entitled, “Suppression of Cytochrome P450 3A4 Activity by UDP-glucuronosyltransferase (UGT) 2B7: The Role of Charged Residue(s) in the Cytosolic Tail of UGT2B7.”
Second Place: James Chun Yip Chan, from the National University of Singapore, for the poster A4 entitled, “Protein Glutathionylation: The Hidden Hand in Acetaminophen Toxicity.”
First Place: Lian Yee Yip, from the National University of Singapore for the poster A5 entitled, “The Gut Microbiome: Implications in Tacrine-induced Transaminitis.”
POST-DOCTORAL AWARDS:Third Place: Shigeru Ogaki, from Kumamoto University, for the poster A10 entitled, “Carbon Monoxide Bound Red Blood Cells Protect the Function of Hepatic Cytochrome P450 After Resuscitation from Hemorrhagic Shock via Suppression of Toll-like Receptor-4 Expression on the Kupffer Cells.”
Second Place: Francis Yoshimoto, from Vanderbilt University, for the poster A7 entitled, “The Mechanism of the Carbon-Carbon Bond Cleavage Step of the Cytochrome P450 19A1 Aromatase Reaction.”
First Place: Yun-Chen Tien, from the University of Connecticut, for the poster A8 entitled, “Impact of Neonatal Drug Exposure on Interindividual Variations of P450-Mediated Drug Metabolism.”
ISSX and JSSX congratulate all poster award recipients and finalists.
Please save the dates and make plans to join us and present a poster at these meetings in 2015:
13th European MeetingThe University of StrathclydeGlasgow, Scotland, UKJune 22–25, 2015Meeting Chairs: Roland Wolf, Ph.D. & Ann Daly, Ph.D.
20th North American MeetingHilton Orlando Bonnet CreekOrlando, Florida, USAOctober 18–22, 2015Meeting Chairs: Hartmut Derendorf, Ph.D. & Stephan Schmidt, Ph.D. Over 540 abstract posters were presented at the 19th North American
ISSX / 29th JSSX Meeting.
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ISSX Welcomes New Members!Martin Almstetter, Philip Morris Products S.A., Switzerland
Conny Barnard, Sinclair Research Center, United States
Randall Baselt, Biomedical Publications, United States
Ken Browne, Technology Networks, United Kingdom
Maureen Bunger, ModernTox, LLC, United States
Esra Cece, Pompeu Fabra University , Spain
Susan Dearborn, Agilux Laboratories, Inc., United States
Matthew Durk, Genentech, Inc., United States
Markus Fluck, Merck Serono, Germany
Sharon Geerts, Massachusetts General Hospital, United States
Niresh Hariparsad, Vertex Pharmaceuticals, United States
Nicole Haste, MyoKardia, United States
Paul Henderson, Accelerated Medical Diagnostics, Inc., United States
Jenny Ho, Philip Morris International, Singapore
Niels Holm, Copenhagen University, Denmark
Tahir Hussain, National University of Sciences and Technology, Pakistan
Ryo Isomata, GL Sciences, Inc., Japan
James Jersey, Agilux Laboratories, Inc., United States
Savannah Kerr, University of Washington, United States
Noriaki Kiya, Fujiyakuhin Co., LTD., Japan
Sylvie Klieber, Sanofi, France
Sookie La, BioCore Co., LTD., Korea
Hee Joo Lee, BioCore Co., LTD., Korea
Donghwan Lee, Sr., Inje University College of Medicine, Korea
Weiqun Li, Calithera Bioscience, United States
Tong Lin, Medivation, United States
Naila Mammadova, Lutheran Medical Center, United States
Jose Marengo, Emory University, United States
Stephen Messham
Patrick O’Hearn, Infinity Pharmaceuticals, United States
Sinan Ozer, Massachusetts General Hospital, United States
Sravan Penchala, University of the Pacific, United States
Jennifer Quigley, Miraca Life Sciences, United States
Wolfgang Sadee, Ohio State University, United States
Sarah Shugarts, Kaiser Permanente, United States
Michael Stoeling II, Aegis Sciences Corporation, United States
Vincent Tong, Theravance Biopharma, United States
Katherine Van Sickle, Chimerix, United States
Shihong Wang, Pharmacyclics, United States
Jenny Wen, Dart Neuroscience Inc., United States
Alan Wolfe, UC San Francisco, United States
Thomas Woolf, Biotranex LLC, United States
Li Yu, Roche Innovation Center New York, United States
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Join us at SLAS 2015, Booth 1029
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PRELIMINARY SCIENTIFIC PROGRAM
Monday, June 22, 2015
Short Course 1: Mass Spectrometry in Drug Metabolism StudiesChairs: Ian Wilson, Imperial College, London, United Kingdom and Neil Kitteringham, University of Liverpool, Liverpool, United Kingdom
Short Course 2: Stem Cell Derived Tissues in ToxicologyChairs: Chris Goldring, University of Liverpool, Liverpool, United Kingdom and Matt Wright, Newcastle University, Newcastle upon Tyne, United Kingdom
Short Course 3: Physiologically-based Pharmacokinetic ModellingChairs: Geoff Tucker, Simcyp Limited, Sheffield, United Kingdom and Brian Houston, University of Manchester, Manchester, United Kingdom
Short Course 4: New Horizons in Mass SpectrometryChairs: Andy Pitt, Aston University, Birmingham, United Kingdom and Neil Kitteringham, University of Liverpool, Liverpool, United Kingdom
Keynote AddressProtein Kinases as Drug Targets, Professor Sir Philip Cohen, University of Dundee, Dundee, United Kingdom
Tuesday, June 23, 2015
Symposium 1: Recent Developments in Stem Cell Technology and its Application to Drug Metabolism and Drug Safety TestingChairs: David Hay, University of Edinburgh, Edinburgh, United Kingdom and Ludovic Vallier, University of Cambridge, Cambridge, United Kingdom
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The meeting will include short courses, keynote lectures delivered by leading researchers, parallel sessions on a wide range of topics, poster sessions, awards presentations, and a trade exhibition. There will be
multiple opportunities for attendees to enjoy scientific and social interaction with friends and colleagues in a purpose-built conference facility in the centre of Glasgow.
Features of this Meeting
SAVE THE DATE FOR THE 13th European ISSX Meeting
June 22-25, 2015University of StrathclydeGlasgow, Scotland
13TH EUROPEAN ISSX MEETING
June 22-25, 2015 | University of Strathclyde | Glasgow, Scotland13TH EUROPEAN ISSX MEETING
ISSX2015GLASGOWSCOTLAND
ISSX2015GLASGOWSCOTLAND
June 22-25, 2015 The University of Strathclyde
Technology and Innovation CentreGlasgow, Scotland
ISSX depends on the support of its members to help us organize our educational activities and to sustain our operations. Please respond to the membership dues notices that will be distributed in late January
2015. Membership dues remain unchanged and go far towards helping us achieve our goals.
ISSX members have access to a variety of exclusive benefits including:
A Subscription to the ISSX Newsletter -‐ Members receive a quarterly newsletter that highlights Society news, member spotlights, upcoming meetings, late breaking scientific news, and much more.
Reduced Registration Fees -‐ Members receive significant discounts on registration fees for all ISSX meetings and workshops.
Recorded Educational Content -‐ New in 2015 -‐ Members can access recorded content online at a reduced members-‐only rate.
Abstract Presentations -‐ Members have the opportunity to submit abstracts to present their work with other leaders in the field at ISSX meetings.
Searchable Meeting Abstracts -‐ Members may perform searches for and cite abstracts from past ISSX meetings.
Networking Opportunities -‐ Meet with other local and international leaders interested in DMPK.
Society Awards Program -‐ Only ISSX members are eligible for the prestigious Scientific Achievement Awards presented at our regional meetings.
Travel Grants -‐ Eligible members may apply for travel assistance to attend ISSX regional and international meetings.
Membership Directory -‐ Our searchable online membership directory makes connecting with fellow researchers convenient.
Special Journal Subscription Discounts -‐ Members receive special subscription discounts to multiple scientific journals, including Drug Metabolism Reviews, Annual Review of Pharmacology and Toxicology, and many more.
Hold Office and Serve on a Committee -‐ Holding a position of leadership in ISSX is a tremendous opportunity to serve your peers worldwide, to develop important skills, help set the work plan of a prestigious international scientific society, and be recognized as a leader volunteer of an international scientific society.
Vote in ISSX Elections -‐ Helping to choose the future leaders of ISSX sets the path of our organization and provides you the opportunity to elect those who best represent your interests.
www.issx.org/membership/renew
Most of all, your membership indicates your support of our mission to advance the understanding of the interactions of medicines and chemicals with living systems and helps sustain our program of
operations. Please support ISSX by renewing your membership today!
ISSX members have access to a variety of exclusive benefits including:
A Subscription to the ISSX Newsletter -‐ Members receive a quarterly newsletter that highlights Society news, member spotlights, upcoming meetings, late breaking scientific news, and much more.
Reduced Registration Fees -‐ Members receive significant discounts on registration fees for all ISSX meetings and workshops.
Recorded Educational Content -‐ New in 2015 -‐ Members can access recorded content online at a reduced members-‐only rate.
Abstract Presentations -‐ Members have the opportunity to submit abstracts to present their work with other leaders in the field at ISSX meetings.
Searchable Meeting Abstracts -‐ Members may perform searches for and cite abstracts from past ISSX meetings.
Networking Opportunities -‐ Meet with other local and international leaders interested in DMPK.
Society Awards Program -‐ Only ISSX members are eligible for the prestigious Scientific Achievement Awards presented at our regional meetings.
Travel Grants -‐ Eligible members may apply for travel assistance to attend ISSX regional and international meetings.
Membership Directory -‐ Our searchable online membership directory makes connecting with fellow researchers convenient.
Special Journal Subscription Discounts -‐ Members receive special subscription discounts to multiple scientific journals, including Drug Metabolism Reviews, Annual Review of Pharmacology and Toxicology, and many more.
Hold Office and Serve on a Committee -‐ Holding a position of leadership in ISSX is a tremendous opportunity to serve your peers worldwide, to develop important skills, help set the work plan of a prestigious international scientific society, and be recognized as a leader volunteer of an international scientific society.
Vote in ISSX Elections -‐ Helping to choose the future leaders of ISSX sets the path of our organization and provides you the opportunity to elect those who best represent your interests.
www.issx.org/membership/renew
Most of all, your membership indicates your support of our mission to advance the understanding of the interactions of medicines and chemicals with living systems and helps sustain our program of
operations. Please support ISSX by renewing your membership today!
ISSX members have access to a variety of exclusive benefits including:
A Subscription to the ISSX Newsletter -‐ Members receive a quarterly newsletter that highlights Society news, member spotlights, upcoming meetings, late breaking scientific news, and much more.
Reduced Registration Fees -‐ Members receive significant discounts on registration fees for all ISSX meetings and workshops.
Recorded Educational Content -‐ New in 2015 -‐ Members can access recorded content online at a reduced members-‐only rate.
Abstract Presentations -‐ Members have the opportunity to submit abstracts to present their work with other leaders in the field at ISSX meetings.
Searchable Meeting Abstracts -‐ Members may perform searches for and cite abstracts from past ISSX meetings.
Networking Opportunities -‐ Meet with other local and international leaders interested in DMPK.
Society Awards Program -‐ Only ISSX members are eligible for the prestigious Scientific Achievement Awards presented at our regional meetings.
Travel Grants -‐ Eligible members may apply for travel assistance to attend ISSX regional and international meetings.
Membership Directory -‐ Our searchable online membership directory makes connecting with fellow researchers convenient.
Special Journal Subscription Discounts -‐ Members receive special subscription discounts to multiple scientific journals, including Drug Metabolism Reviews, Annual Review of Pharmacology and Toxicology, and many more.
Hold Office and Serve on a Committee -‐ Holding a position of leadership in ISSX is a tremendous opportunity to serve your peers worldwide, to develop important skills, help set the work plan of a prestigious international scientific society, and be recognized as a leader volunteer of an international scientific society.
Vote in ISSX Elections -‐ Helping to choose the future leaders of ISSX sets the path of our organization and provides you the opportunity to elect those who best represent your interests.
www.issx.org/membership/renew
Most of all, your membership indicates your support of our mission to advance the understanding of the interactions of medicines and chemicals with living systems and helps sustain our program of
operations. Please support ISSX by renewing your membership today!
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Symposium 2: Expanding the Boundaries of PKPD ModellingChairs: Geoff Tucker, Simcyp Limited, Sheffield, United Kingdom and Brian Houston, University of Manchester, Manchester, United Kingdom
Symposium 3: Systems ToxicologyChairs: Paul Watkins, The Hamner Institues for Health Sciences, Research Triangle Park, NC, United States and Bob van de Water, Leiden University, Leiden, Netherlands
Symposium 4: Clinical Implementation of PharmacogenomicsChairs: Ann Daly, Newcastle University, Newcastle upon Tyne, United Kingdom and Matthias Schwab, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
Symposium 5: Role of Drug Transporters: Current and Future Perspectives (an ITC Sponsored Symposium)Chairs: Donald Tweedie, Boehringer Ingelheim, Ridgefield, CT, United States and Brian Houston, University of Manchester, Manchester, United Kingdom
Symposium 6: Advances in Pathways of Chemically-induced Oxidative Stress and DNA DamageChairs: John Hayes, University of Dundee, Dundee, United Kingdom and Ken Tew, Medical University of South Carolina, Charleston, SC, United States
Wednesday, June 24, 2015
Symposium 7: Humanised Animal Models in Drug DevelopmentChairs: Colin Henderson, University of Dundee, Dundee, United Kingdom and Frank Gonzalez, National Cancer Institute, Bethesda, MD, United States
Symposium 8: The Contribution of the Gut Microbiome to Drug Metabolism, Drug Interactions and Drug ToxicityChairs: Heather Wallace, University of Aberdeen, Aberdeen, United Kingdom and Elaine Holmes, Imperial College London, London, United Kingdom
Symposium 9: Epigenomics in Drug Metabolism and DiseaseChairs: Richard Meehan, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom and Jonathan Moggs, Novartis, Basel, Switzerland
Symposium 10: Proteins as Targets for Covalent Modification by Xenobiotics: Therapeutic Opportunities versus Toxicological RiskChairs: Tom Baillie, University of Washington, Seattle, WA, United States and Kevin Park, University of Liverpool, Liverpool, United Kingdom
Thursday, June 25, 2015
Symposium 11: Predicting Human Responses During Drug Discovery and DevelopmentChairs: Roland Wolf, University of Dundee, Dundee, United Kingdom and Peter Moldeus, Karolinska Institute, Stockholm, Sweden
Symposium 12: Conjugating Enzymes and Hydrolases in Endogenous and Foreign Compound MetabolismChairs: Michael Arand, University of Zurich, Zurich, Switzerland and John Miners, Flinders University, Adelaide, Australia
Plenary Session: Inflammation: Effects on Drug Metabolism and Disease AetiologyChairs: Kathie Knights, Flinders University, Adelaide, Australia and Eddie Morgan, Emory University, Atlanta, GA, United States
Special Closing Keynote LectureFrank Gonzalez, National Cancer Institute, Bethesda, MD, United States
ABSTRACTS
The Call for Abstracts is Now Open! We encourage all those involved in the fields of metabolism, pharmacology, toxicology, molecular biology and other related disciplines to consider submitting an abstract for a poster presentation at the 13th European ISSX. This meeting will provide a wonderful opportunity to showcase work being done in a variety of areas and to network with other researchers. Present a poster in the general abstract poster sessions. Compete in the poster award competition open to pre- and post-doctoral students. Visit www.issx.org/13euro/abstracts for more information on the submission process.
SOCIAL PROGRAM
Opening Welcome ReceptionStart the meeting at the Opening Welcome Reception in the exhibition and poster area of the Technology and Innovation Centre on Monday, June 22. Enjoy hors d’oeuvres and drinks while you meet with our meeting exhibitors and fellow attendees. This event is included with full meeting registration and guest ticket purchase.
Civic ReceptionThe Glasgow City Council will welcome ISSX to Glasgow with a Civic Reception on Tuesday, June 23 at 18:30 to include a complimentary beverage. This unique event will be held in the prestigious surroundings of the City Chambers in the Picture Gallery which was opened in 1888. The Lord Provosts of the City will be in attendance to greet delegates and welcome you to Glasgow. The City Chambers is in the very heart of Glasgow and is one of the city’s most important and prestigious buildings. A grand and imposing edifice overlooking George Square, the City Chambers is an impressive symbol of Glasgow’s political strength and historical wealth. Completed in 1888, the City Chambers has for over 100 years been the headquarters of successive councils serving the City of Glasgow. This event is complimentary, but advance registration is required..
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Meeting Dinner and CeilidhJoin us at the premier social event of the meeting at the Old Fruit Market of Glasgow which has kept all of its period charm, including its lofty vaulted roof cast iron columns and balcony and slender Victorian architecture. Attendees
will enjoy a delicious buffet dinner, drinks, and a ceilidh.
Make plans to join us at the Old Fruit Market on Wednesday, June 24. Separate registration fee applies.
REGISTRATION FEES Early Regular On-SiteShort Courses January 1–March 20, 2015 March 21–June 21, 2015 June 22–25, 2015All Prices in US Dollars
ISSX Member $175 $225 $250Nonmember $225 $275 $325Student Member $100 $125 $150Student Non-Member $125 $150 $175
Early Regular On-SiteMeeting Registration January 1–March 20, 2015 March 21–June 21, 2015 June 22–25, 2015All Prices in US Dollars
ISSX Member $615 $715 $795Nonmember $775 $845 $955Student Member $250 $275 $300Student Non-Member $275 $300 $325Guest $50 $50 $50
REGISTRATION INFORMATIONThe meeting registration fee includes admittance to:
• Scientific Symposia and Special Lectures • Awards Presentation and Lectures • Poster Presentation • Poster Awards Competition Review and Awards Session • Exhibition • Civic Reception • Opening Welcome Reception
The short courses are separately ticketed offerings and may be added to a registration at an additional fee. Register today at www.issx.org/13euro/register.
Please note: The meeting registration fee does not include access to the Short Courses or the ISSX Social Event at the Old Fruit Market. Guest registration includes a meeting tote bag and admission to the opening welcome reception
and all refreshment breaks. Guest registration does not include admittance to the scientific sessions or the ISSX Social Event at the Old Fruit Market. Tickets to the social event may be purchased for guests in advance.
AccommodationsISSX has arranged for special rates at several hotels in different price categories in the area near the Technology and Innovation Centre in Glasgow. The hotels are within walking distance to the meeting facility. Attendees are welcome to secure lodging at alternative venues.
Reservations for hotels in our housing block will be accepted on a first-come, first-served basis. A limited number of hotel rooms are available at each property. Reservations will be accepted based upon availability up to two weeks before our meeting convenes. It is to the attendee’s advantage to reserve their hotel accommodations as soon as possible.
Reserve lodging via this web site: www.issx.org/13euro/hotel
Awards ProgramNominations are currently being accepted for the scientific achievement awards for established and new investigators to be presented at the 13th European ISSX Meeting in June 2015 in Glasgow. Visit www.issx.org/awards for details and to submit a nomination.
Climate/Time ZoneThe month of June is characterized by gradually rising daily high temperatures, with daily highs around 17° C (63°F) throughout the month, sometimes exceeding 23° C (73°F). The daily low temperature ranges from 8° C (47°F) to 11° C (51°F).
Glasgow is located in the Greenwich Mean Time zone and Daylight Saving Time will be observed at the time of the meeting.
Exhibit HallTop suppliers will be on hand to share the latest products and services to help you advance your research. Be sure to pack your business cards.
GENERAL INFORMATION
Deadline for the submission* of material to the ISSX Office:
ISSUE MATERIALS DEADLINE RELEASE DATE
Issue 1 February 13, 2015 March 2015
Issue 2 May 15, 2015 June 2015
Issue 3 August 14, 2015 September 2015
Issue 4 November 13, 2015 December 2015
*Subject to change
Editor Dr. Allen Cato, IIICato Research, LTD6480 Weathers Place, Suite 104San Diego, California 92121USATelephone: +1-858-452-7271Fax: +1-858-452-7784E-mail: [email protected]
ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact [email protected].
Advertise with ISSX in the quarterly ISSX Newsletter. Rates and additional advertising opportunities are available at www.issx.org/advertising2015.
Change of AddressIf your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact [email protected].
Advertise with ISSX
The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings,
and more. This publication is designed to update the ISSX membership on the activities and events of the organization
and to provide an information forum.
Not only is the ISSX Newsletter promoted directly to all ISSX Members, but, as of 2012, it is also available
to anyone who visits the ISSX Web site.
Visit www.issx.org/advertising2015 today!
Searching for experts in the field of drug metabolism, pharmacokinetics, pharmacodynamics, and other related areas? The ISSX Career Center job board is your premier resource to find skilled applicants.
• Create your Company Profile free of charge and explain the organization and work environment in detail.
• When your positions are advertised on the ISSX Career Center, an e-mail advertising the position is sent automatically to job seekers who have requested notifications about opportunities matching their search criteria.
• Browse résumés for free and pay only for the résumés that you select.
Post your jobs online today! When you use the ISSX Career Center, you ensure that your open positions are advertised in the right place. Visit www.issx.org/careercenter.
ISSX CAREER CENTER
