INSTITUTE OF ANTIMICROBIAL CHEMOTHERAPYINSTITUTE OF ANTIMICROBIAL CHEMOTHERAPY

SMOLENSK STATE MEDICAL UNIVERSITYSMOLENSK STATE MEDICAL UNIVERSITY

Roman S. Kozlov

Director

Roman S. Kozlov

Director

20002000Establishment of National Scientific Center of the Russian Ministry of Health

of Monitoring Antimicrobial ResistanceEstablishment of National Scientific Center of the Russian Ministry of Health

of Monitoring Antimicrobial Resistance

20152015Organization of WHO Collaborating Centre for Capacity Building on

Antimicrobial Resistance Surveillance and Research initiatedOrganization of WHO Collaborating Centre for Capacity Building on

Antimicrobial Resistance Surveillance and Research initiated

IAC OF SSMU: MILESTONESIAC OF SSMU: MILESTONES

Clinical pharmacology courseClinical pharmacology course19861986

19871987PK laboratory in regional hospitalPK laboratory in regional hospital

Initiation of clinical trialsInitiation of clinical trials19871987

19901990Bioequivalence studies in volunteersBioequivalence studies in volunteers

19991999

Laboratory of molecular microbiology in regional hospitalLaboratory of molecular microbiology in regional hospital19971997

Institute of Antimicrobial Chemotherapyof Smolensk State Medical Academy

Institute of Antimicrobial Chemotherapyof Smolensk State Medical Academy

SCIENTIFIC ACTIVITIESSCIENTIFIC ACTIVITIES

1993-1995, 2 cities

MoscowMoscowSmolenskSmolensk

1995-1997, 9 cities

Saint-Petersburg

Nizhny Novgorod

Krasnodar Yekaterinburg

Kazan

NovosibirskKrasnoyarsk

Saint-PetersburgSaint-Petersburg

Nizhny NovgorodNizhny Novgorod

KrasnodarKrasnodar YekaterinburgYekaterinburg

KazanKazan

NovosibirskNovosibirskKrasnoyarskKrasnoyarsk

1997-2000, 15 cities

Ryazan

Stavropol Tomsk

Ufa

Omsk

Vladivostok

RyazanRyazan

StavropolStavropol TomskTomsk

UfaUfa

OmskOmsk

VladivostokVladivostok

2000-2005, 30 cities

Archangelsk

Volgograd

Voronezh

Irkutsk

Perm

TyumenChelyabinsk

Yaroslavl

Novokuznetsk

Yakutsk

Kovrov

Vologda

Penza

Khabarovsk

ArchangelskArchangelsk

VolgogradVolgograd

VoronezhVoronezh

IrkutskIrkutsk

PermPerm

TyumenTyumenChelyabinskChelyabinsk

YaroslavlYaroslavl

NovokuznetskNovokuznetsk

YakutskYakutsk

KovrovKovrov

VologdaVologda

PenzaPenza

KhabarovskKhabarovsk

MinskMinskMinsk

2005-2015, 50 cities

Kaluga

Kemerovo

Lipetsk Noyabrsk

Orel

Rostov-on-DonSeversk

Tolyatti

Astana

Gomel

DhezkazganKaraganda

Mogilev

Nijnevartovsk

RostovCherepovets

Kiev

DnepropetrovskIzhevsk

Kirov

KalugaKaluga

KemerovoKemerovo

LipetskLipetsk NoyabrskNoyabrsk

OrelOrel

Rostov-on-DonRostov-on-DonSeverskSeversk

TolyattiTolyatti

AstanaAstana

GomelGomel

DhezkazganDhezkazganKaragandaKaraganda

MogilevMogilev

NijnevartovskNijnevartovsk

RostovRostovCherepovetsCherepovets

KievKiev

DnepropetrovskDnepropetrovskIzhevskIzhevsk

KirovKirov

PARTICIPANTS OF IAC MICROBIOLOGICAL PROJECTSPARTICIPANTS OF IAC MICROBIOLOGICAL PROJECTS

Russia

Belarus

Ukraine

Kazakhstan

MoldovaKishinevKishinev

More than 60 local centers in different regions of Russia, Belarus, Kazakhstan, Ukraine and MoldovaMore than 60 local centers in different regions of Russia, Belarus, Kazakhstan, Ukraine and Moldova

AnadyrAnadyr

BarnaulBarnaul

BryanskBryansk

VitebskVitebsk

GrodnoGrodno

KislovodskKislovodsk

MurmanskMurmansk

Naberezhnye ChelnyNaberezhnye Chelny

Nizhni TagilNizhni Tagil

PetrozavodskPetrozavodsk

SamaraSamaraSurgutSurgut

Ulan-UdeUlan-Ude

Khanty-MansyiskKhanty-Mansyisk

The only institution conducting consistent national studies on antimicrobial resistance in Russian Federation

The only institution conducting consistent national studies on antimicrobial resistance in Russian Federation

Federal governmental grants since 2012− 7 -accomplishing annually− 8 - scheduled in 2016

Federal governmental grants since 2012− 7 -accomplishing annually− 8 - scheduled in 2016

SUPPORT ON NATIONAL LEVELSUPPORT ON NATIONAL LEVEL

Speech at the First session of the Council for the Development of Social Innovations of the Russian Federation subject of the Federation Council of the Federal Assembly: “Innovative medicine: challenges and perspectives”, March 2015

Speech at the First session of the Council for the Development of Social Innovations of the Russian Federation subject of the Federation Council of the Federal Assembly: “Innovative medicine: challenges and perspectives”, March 2015

SCIENTIFIC COLLABORATION WITH LEADING DOMESTIC RESEARCH CENTRESSCIENTIFIC COLLABORATION WITH LEADING DOMESTIC RESEARCH CENTRES

Contracts with Federal Agency for Control for Customer Protection and Human Welfare for studies in the field of AB-resistance accomplishment:

2001-2005 – National Program on Study of AB Resistance Mechanisms

2006-2010 – National Monitoring of AB Resistance

2011-2015 – Scientific researches and developments for providing of sanitary and epidemiological safety and decrease of infectious diseases in Russian Federation

Contracts with Federal Agency for Control for Customer Protection and Human Welfare for studies in the field of AB-resistance accomplishment:

2001-2005 – National Program on Study of AB Resistance Mechanisms

2006-2010 – National Monitoring of AB Resistance

2011-2015 – Scientific researches and developments for providing of sanitary and epidemiological safety and decrease of infectious diseases in Russian Federation

Research Institute of Epidemiology & Microbiology named under Gamaleya

Federal Center of External Clinical & Laboratory Studies Quality Control

Institute of New Antibiotics named under Gauze

Central Research Institute on Epidemiology

Research Institute of Pediatric Infections

State Scientific Center on Antibiotics

Research Institute of Physicochemical Medicine

Research Institute of Epidemiology & Microbiology named under Gamaleya

Federal Center of External Clinical & Laboratory Studies Quality Control

Institute of New Antibiotics named under Gauze

Central Research Institute on Epidemiology

Research Institute of Pediatric Infections

State Scientific Center on Antibiotics

Research Institute of Physicochemical Medicine

SCIENTIFIC COLLABORATION WITH LEADING DOMESTIC RESEARCH CENTRESSCIENTIFIC COLLABORATION WITH LEADING DOMESTIC RESEARCH CENTRES

International AB-resistance studies PHE (London, UK)

Hershey Medical Center (Hershey, USA)

Universita’ Degli Studi Di Siena (Siena, Italy)

Hôpital de Bicêtre (Paris, France)

International AB-resistance studies PHE (London, UK)

Hershey Medical Center (Hershey, USA)

Universita’ Degli Studi Di Siena (Siena, Italy)

Hôpital de Bicêtre (Paris, France)

SCIENTIFIC COLLABORATION WITH LEADING FOREIGN RESEARCH CENTRESSCIENTIFIC COLLABORATION WITH LEADING FOREIGN RESEARCH CENTRES

New molecular genetic methods of AB-resistance study development Karolinska Inst., Center for Genomics Research (Stockholm, Sweden)

Epoch Biosciences (Bothell, USA)

New molecular genetic methods of AB-resistance study development Karolinska Inst., Center for Genomics Research (Stockholm, Sweden)

Epoch Biosciences (Bothell, USA)

Students and workers training Fox Chase Cancer Center (Philadelphia, USA)

Students and workers training Fox Chase Cancer Center (Philadelphia, USA)

ESCMID (European Society of Clinical Microbiology and

Infectious Diseases)

ISC (International Society of Chemotherapy)

FEMS (Federation of European Microbiological Societies)

ASM (American Society of Microbiology)

USP (United States Pharmacopeial Convention)

USAID (United States Agency for International Development)

APUA (Alliance for the Prudent Use of Antibiotics)

Urological Association of Asia

ESCMID (European Society of Clinical Microbiology and

Infectious Diseases)

ISC (International Society of Chemotherapy)

FEMS (Federation of European Microbiological Societies)

ASM (American Society of Microbiology)

USP (United States Pharmacopeial Convention)

USAID (United States Agency for International Development)

APUA (Alliance for the Prudent Use of Antibiotics)

Urological Association of Asia

SCIENTIFIC COLLABORATION WITH LEADING FOREIGN SOCIETIES AND ORGANIZATIONSSCIENTIFIC COLLABORATION WITH LEADING FOREIGN SOCIETIES AND ORGANIZATIONS

EDUCATIONAL ACTIVITYEDUCATIONAL ACTIVITY

Since 1999 IAC carried out more than 100 conferences,

international engagement among them, in more than 30 regions of

Russian Federation

Common number of lectures is close to 800, about 30% was

delivered by IAC workers

Number of trainees in each conference

is from 300 till 1200

Since 1999 IAC carried out more than 100 conferences,

international engagement among them, in more than 30 regions of

Russian Federation

Common number of lectures is close to 800, about 30% was

delivered by IAC workers

Number of trainees in each conference

is from 300 till 1200

EDUCATIONAL ACTIVITYEDUCATIONAL ACTIVITY

MICROBIOLOGY WORKSHOPSMICROBIOLOGY WORKSHOPS

TheoryTheory

PracticePractice

MICROBIOLOGY WORKSHOP PARTICIPANTSMICROBIOLOGY WORKSHOP PARTICIPANTS2013

2014

2015

WEB-PORTAL ON CLINICAL MICROBIOLOGY AND PHARMACOLOGY for health-care workersWEB-PORTAL ON CLINICAL MICROBIOLOGY AND PHARMACOLOGY for health-care workers

3.9 thousands unique visits per day in November 2010 3.9 thousands unique visits per day in November 2010

DYNAMICS OF ANTIBIOTIC.ru VISITSDYNAMICS OF ANTIBIOTIC.ru VISITS

Hits in a day per month

Hits in a day per month

13 000

12 00011 00010 000

9 000

8 0007 0006 000

5 000

4 000Jun 13 Sep 13 Dec 13 Mar 14 Jun 14 Sep 14 Dec 14 Mar 15 Jun 15 Sep 15 Dec 15

From 6.1 to 13.0 thousands unique visits per day in 2015 From 6.1 to 13.0 thousands unique visits per day in 2015 Top 10 among 306 scientific & medical sites on rating Yandex.Medicine Top 10 among 306 scientific & medical sites on rating Yandex.Medicine

INFECTIONS.RU

NEW WEB-PORTAL ABOUT INFECTIONS AND DIAGNOSTICS for patientsNEW WEB-PORTAL ABOUT INFECTIONS AND DIAGNOSTICS for patients

DYNAMICS OF INFECTIONS.ru VISITSDYNAMICS OF INFECTIONS.ru VISITS

3 1002 9002 700

2 500

2 3002 1001 900

1 700

1 500Jan 15 Feb 15 Mar 15 Apr 15 May 15 Jun 15 Jul 15 Aug 15 Sep 15 Oct 15 Nov 15

From 1.7 to 2.4 thousands unique visits per day in 2015 From 1.7 to 2.4 thousands unique visits per day in 2015 707.9 thousands unique visits in 2015 707.9 thousands unique visits in 2015

Hits in a day per month

Hits in a day per month

www.ANTIBIOTIC-SAVE.ru

NEW WEB-PORTAL ABOUT RATIONAL ANTIBIOTIC USE for pharmacists, physicians and patientsNEW WEB-PORTAL ABOUT RATIONAL ANTIBIOTIC USE for pharmacists, physicians and patients

PUBLISHING ACTIVITIESPUBLISHING ACTIVITIES

IAC PUBLICATIONS IN INTERNATIONAL JOURNALSIAC PUBLICATIONS IN INTERNATIONAL JOURNALS

PERIODICALSPERIODICALS

Publishing since 1999

quarterly

Peer-reviewed

Included to Higher

Attestation Commission list

from 2002

International review

Print-out - 2,500-3,000

Publishing since 1999

quarterly

Peer-reviewed

Included to Higher

Attestation Commission list

from 2002

International review

Print-out - 2,500-3,000

PUBLISHING ACTIVITIESPUBLISHING ACTIVITIES 6 full-text practical guidelines

«Clinical Microbiology and Antimicrobial Chemotherapy» journal

36 guides and manuals

Articles in peer-reviewed journals

Presentations and abstracts from Russian and international conferences

Circulars

Textbooks and manuals for students

6 full-text practical guidelines

«Clinical Microbiology and Antimicrobial Chemotherapy» journal

36 guides and manuals

Articles in peer-reviewed journals

Presentations and abstracts from Russian and international conferences

Circulars

Textbooks and manuals for students

Guidelines on antimicrobial

chemotherapy

Total print-out – 55,000 copies

Sent to doctors from 63 Russian regions and other

Russian-speaking countries free of charge

Guide on Infection Control in Hospitals

2003

Print-out - 15,000 copies

2004. Educational Association Approval. Print-out - 500 copies

2005. Educational Association Approval. Print-out - 500 copies

FUTURE DIRECTIONSFUTURE DIRECTIONS

х Erorrs in detecting of antimicrobial resistanceх Imprecision of results with IAC laboratory Valid diagnostics by local laboratory Training of laboratories stuff Evaluation of laboratories facility and consumables equipment levelCollection of nosocomial strains by local laboratories in different citiesOrganization of accredited laboratories networkin different regions

abCloud: THE PRINCIPLEabCloud: THE PRINCIPLEStrains identification by local laboratory

!

!

!

! !

!

Strains and identification data transfer to IAC

Smolensk

Strains reidentification in IAC laboratory

! Accreditation of local laboratory

Х

Х

Fast informing about current state of antimicrobial resistance in different regions

Smolensk

Х

Х

On-line access to server for accreditated laboratoriesAutomated tests results transfer to IAC serverSoftware data processing with automated graphic projection on antimicrobial resistance map Free map access to any user

www.antibiotic.ru

Innovative informational system for healthcare specialists and population

Single innovative data baseabCloud: THE RESULTabCloud: THE RESULT

abCloud REPORTING DATA:MAP OF ANTIMICROBIAL RESISTANCE IN RUSSIAabCloud REPORTING DATA:MAP OF ANTIMICROBIAL RESISTANCE IN RUSSIA

RESISTANCE TO ANTIMICROBIALS –GLOBAL THREAT TO MANKINDRESISTANCE TO ANTIMICROBIALS –GLOBAL THREAT TO MANKIND

NO ANTIBIOTICS…NO CURE