NAME PRESENT TITLE (s) Molecular Genetics UTHealth ... · International Journal of Antimicrobial Agents, Antimicrobial Agents and Chemotherapy, Journal of Antimicrobial Chemotherapy,

9/22/2018

CURRICULUM VITAE NAME Cesar A. Arias, M.D., MSc., Ph.D. PRESENT TITLE (s)

Professor of Medicine (Infectious Diseases), Microbiology and Molecular Genetics UTHealth McGovern Medical School Herbert L. and Margaret W. DuPont Chair in Infectious Diseases, UTHealth School of Public Health Director, Center for Antimicrobial Resistance and Microbial Genomics (CARMiG) and Laurel and Robert H. Graham Faculty Fellow, UTHealth McGovern Medical School Director, Center for Infectious Diseases. The University of Texas Health Science Center, School of Public Health Faculty Member, Graduate School of Biological Sciences UTHealth-UT MD Anderson Cancer Center Adjunct Professor, UT MD Anderson Cancer Center Director, Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics Universidad El Bosque, Colombia Adjunct Professor, Universidad Del Desarrollo, Clinica Alemana, Santiago, Chile

ADDRESS 6431 Fannin St., MSB 2.112, Houston, TX 77030 BIRTHDATE

March 1, 1969

CITIZENSHIP

Colombian, US permanent Resident

UNDERGRADUATE EDUCATION

Universidad El Bosque, School of Medicine Santa Fé de Bogotá, Colombia Dec 1986 - Dec 1992 Degree: MD

GRADUATE EDUCATION

University of London, St. Bartholomew’s and The Royal London Hospital School of Medicine and Dentistry London, United Kingdom Sep 1994 - Dec 1996 Degree: MSc in Clinical Microbiology. Thesis: “Organization of capsule genes in Streptococcus pneumoniae”

University of Cambridge, Department of Biochemistry Cambridge, United Kingdom

Cesar A. Arias, M.D., MSc., Ph.D. FIDSA

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Jan 1997- Jun 2000 Degree: PhD, Molecular Biology and Microbial Biochemistry. Thesis: “Molecular mechanisms of resistance to vancomycin in Enterococcus gallinarum BM4174”

POSTGRADUATE TRAINING

The University of Texas McGovern Medical School at Houston and MD Anderson Cancer Center, Houston, TX., USA Internal Medicine Residency and Infectious Disease Fellowship Clinical Investigator Pathway Jul 2002 – Apr 2008

ACADEMIC APPOINTMENTS

Mar 1993-Sep 1994 Instructor Universidad El Bosque, School of Medicine, Bogotá, Colombia Mar 1993-Mar 1994 Social Service Year Organ Transplant Section, Department of Surgery, Fundación Santa Fé de Bogotá, Bogotá, Colombia Jan 1996 - Dec 1996 Research Scholar in Molecular Microbiology University of London, St Bartholomew’s and the Royal London School of Medicine and Dentistry London, United Kingdom Jan 2000 – Jan 2002 Wellcome Trust International Fellow Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom Jan 2000 – Jan 2002 Bye Fellow, St Edmund’s College University of Cambridge Cambridge, United Kingdom Jan 2000 - Jun 2002 Assistant Professor of Medicine Universidad El Bosque, School of Medicine Bogotá, Colombia Jan 2000 – Present Director, Molecular Genetics and Antimicrobial Resistance Unit Universidad El Bosque, Bogotá, Colombia Apr 2008 – August 2011 Assistant Professor of Medicine Department of Internal Medicine, Division of Infectious Diseases The University of Texas Medical School at Houston Apr 2008 – Present


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Director, Laboratory for Antimicrobial Research Department of Internal Medicine, Division of Infectious Diseases The University of Texas Medical School at Houston May 2010 - Present Research Affiliate Centro Internacional de Investigaciones Medicas (CIDEIM) Cali, Colombia Jan 2010 – Present International Advisor, New University Hospital Universidad El Bosque, Colombia Sep 2011- Aug 2013 Associate Professor of Medicine Department of Internal Medicine, Division of Infectious Diseases The University of Texas Medical School at Houston Sep 2013- Aug 2016 Awarded Tenure, Associate Professor of Medicine Department of Internal Medicine, Division of Infectious Diseases The University of Texas Medical School at Houston May 2015 – Present Director, International Center for Microbial Genomics Universidad El Bosque, Bogota, Colombia May 2016 – Present Director Center for Antimicrobial Resistance and Microbial Genomics (CARMiG) August 2016 – Present Chair, Antimicrobial Resistance Cluster, Gulf Coast Consortia Sep 2016- Present Professor of Medicine Department of Internal Medicine, Division of Infectious Diseases The University of Texas Medical School at Houston Sep 2016 – Present Adjunct Professor UT MD Anderson Cancer Center, Houston, TX Apr 2017 – Jul 2017 Visiting Professor Nuffield Department of Medicine, Infectious Diseases and Microbiology, University of Oxford, United Kingdom. Sep 2017 – Present Adjunct professor, Universidad Del Desarrollo, Clinica Alemana, Santiago, Chile.


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Sep 2017 – Present Director, Center for Infectious Diseases. UTHealth School of Public Health

HOSPITAL APPOINTMENTS

Oct 1992 - Dec 1992 Massachusetts General Hospital and Brigham and Women‘s Hospital. Harvard Medical School (selected for special rotation in Internal Medicine). Boston, MA, USA Mar 1993-Mar 1994 Department of Surgery (Social Service Year) Fundación Santa Fé de Bogotá Bogotá, Colombia Jan 2001- Jun 2002 Department of Surgery, Consultant in Clinical Microbiology Fundación Santa Fé de Bogotá, Bogotá, Colombia Jun 2008 - Present Memorial Hermann Hospital, Texas Medical Center, Houston, TX

Jun 2008 - Present Lyndon B. Johnson General Hospital Houston, TX

LICENSURE Texas Medical Board Unrestricted Medical License, Issued Sep 8, 2007

CERTIFICATION

Apr 1999 Educational Commission for Foreign Medical Graduates USA Nov 2005 Internal Medicine, American Board of Internal Medicine Jan 2008 Infectious Diseases, American Board of Internal Medicine Oct 2015 Internal Medicine, Recertification American Board of Internal Medicine

PROFESSIONAL ORGANIZATIONS (AND COMMITTEES OF THESE)

Local -Houston Infectious Disease Society, Member since 2007 National and International -American Society for Microbiology (1996- present) -Infectious Diseases Society of America, (2003-present)


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-Colombian Infectious Disease Society (2007- present) -Latin American Society of Pediatric Infectious Diseases (2009) - Panamerican Society of Infectious Disease (2010-oresent -American Society of Clinical Investigation (elected member in 2015)

HONORS AND AWARDS

Dec 1992, BEST STUDENT AWARD Universidad El Bosque, School of Medicine Jun 1994 - Jun 1995, COLFUTURO (Corporation for the Future of Colombia) SCHOLARSHIP Joint charity between Colombian government and private enterprises. Funded MSc in Clinical Microbiology, University of London

Jan 1995 – Dec 2000, OVERSEAS RESEARCH STUDENT AWARD Committee of Vice-Chancellors and Principals of The Universities of The United Kingdom. Funded part of Ph.D. program, Department of Biochemistry, University of Cambridge

Jan 1997- Dec 2000, COLCIENCIAS SCHOLARSHIP Colombian Institute for Development of Science and Technology, “Francisco José de Caldas”. Funded part of Ph.D. program Department of Biochemistry, University of Cambridge

Mar 1998, BRITISH SOCIETY FORTHE STUDY OF INFECTION / HOECHST MARION ROUSSEL AWARD, Funded research period at the Unité des agents Antibactériens Institute Pasteur, Paris, France

Sep 1998, ASM SUSTAINING MEMBER STUDENT TRAVEL GRANT Funded attendance to the 38th Interscience Congress on Antimicrobial Agents and Chemotherapy, San Diego, CA, 1998

Jul 1999, CAMBRIDGE OVERSEAS TRUST AWARD Jul 1999, LUNDREN FUND AWARD From The Board of Graduate Studies University of Cambridge United Kingdom Jan 2000- Jan 2002, WELLCOME TRUST INTERNATIONAL DEVELOPMENT AWARD Funded collaborative research on the molecular basis of resistance to antibiotics between the Bacterial Molecular Genetics Unit, Universidad El Bosque, Colombia and Department of Biochemistry, University of Cambridge, United Kingdom


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Apr 2000, SEBASTIAN BAGO AWARD Awarded to the best work on antibiotic therapy International Society for Infectious Diseases Buenos Aires, Argentina

May 2002, YOUNG INVESTIGATOR AWARD, BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY 4th European Congress of Chemotherapy and Infection Paris, France

Sep 2002, ICAAC MERCK IRVING S. SIGAL/ YOUNG INVESTIGATOR AWARD, AMERICAN SOCIETY FOR MICROBIOLOGY, 42nd Annual ICAAC, San Diego, CA., September, 2002

Mar 2004, ALPHA- OMEGA - ALPHA HONOR MEDICAL SOCIETY The University of Texas Medical School at Houston May 2009, UNIBOSQUE GLOBAL ALUMNI (UBOGA) AWARD, Recognition for Outstanding Professional Achievement Washington, DC Oct, 2009, UT YOUNG INVESTIGATOR RECOGNITION AWARD The University of Texas Health Science Center at Houston Houston, TX Apr, 2011, ISIDRO ZAVALA MEDAL Pan-American Society for Infectious Diseases Punta del Este, Uruguay May, 2012, DEAN’S TEACHING EXCELLENCE AWARD The University of Texas Health Science Center at Houston Houston, TX Jun 2011- Present Honorary Associate Professor Universidad El Bosque, School of Medicine May, 2013, DEAN’S TEACHING EXCELLENCE AWARD The University of Texas Health Science Center at Houston Houston, TX Oct, 2013, OSWALD AVERY AWARD FOR EARLY CAREER ACHIEVEMENT Infectious Diseases Society of America, IDSA May, 2014, DEAN’S TEACHING EXCELLENCE AWARD The University of Texas Health Science Center at Houston Houston, TX


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Apr, 2015. ELECTED MEMBER, American Society of ClinicaI Investigation Oct, 2015. FELLOW Infectious Diseases Society of America Mar, 2016. UT SYSTEMS TRANSLATIONAL STARS AWARD Jan, 2017. Laurel and Robert H. Graham Faculty Fellow at McGovern Medical School Sep, 2017. Herbert L. and Margaret W. DuPont Chair in Infectious Diseases

EDITORIAL POSITIONS

Editor 2014-present Antimicrobial Agents and Chemotherapy, American Society for Microbiology Associate Editor, 2016-present Annals of The New Your Academy of Sciences, Antimicrobial Therapeutics Reviews Editorial Boards 2006- Present Revista de la Escuela Colombiana de Medicina Universidad El Bosque 2008-Present Infectio (Official publication of the Colombian Society for Infectious Diseases) Ad-Hoc Reviewer International Journal of Antimicrobial Agents, Antimicrobial Agents and Chemotherapy, Journal of Antimicrobial Chemotherapy, European Journal of Clinical Microbiology and Infectious Diseases, Expert Opinion on Pharmacotherapy, Annals of Clinical Microbiology and Infectious Diseases, Biomedica, Journal of Clinical Microbiology, Pharmacology, Clinical Infectious Diseases, Journal of Clinical Nephrology, Lancet, Lancet Infectious Diseases, Emerging Infectious Diseases, International Journal of Infectious Diseases, Mayo Clinic Proceedings, Clinical Microbiology and Infection, Infectio, Revista Chilena de Infectologia, Drugs, Future Medicine, Diagnostic Microbiology and Infectious Diseases, Journal of Infection, Virulence, BMC Infectious Diseases, PLoS One, Microbial Drug Resistance, New England Journal of Medicine, Nature Reviews Microbiology, Infection Control and Hospital Epidemiology, Open Forum in Infectious Diseases, Emerging Infectious Diseases, Nature


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Microbiology, Science Translational Medicine, JAMA, mBio, Science Editorial Awards Jun 2010, Outstanding Manuscript Review, Clinical Infectious Diseases Infectious Diseases Society of America

SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES

Jan 1997- Dec 1999 (President) Jan 1996 – Dec 1996 (Secretary) Colombian Science and Technology Network Registered Charity in the United Kingdom No. 1047026 London, United Kingdom Feb 1997- Feb 1998 Welfare Officer St Edmund’s College, University of Cambridge Cambridge, UK Sep 2001- Present International Symposium on Antimicrobial Resistance Chairman and Founder (2001) Scientific Committee Board Member (2002- Present) Colombia Feb 2012 NIH-NIAID Microbiology and Infectious Diseases Study Section A Ad-Hoc reviewer Jul 2012 – Jul 2018 NIH-NIAID Microbiology and Infectious Diseases Study Section A Standing Member Jul 2012 Chairman, 4th International American Society for Microbiology Conference on Enterococci Sept 2013 – Present IDWeek Program Committee Member Infectious Diseases Society of America Dec 2014 Reviewer, grant and faculty appointment reviewer Institute Pasteur, Paris Jan 2015 – Present NIH Antimicrobial Resistance Leadership Group. Member of Gram-positive Committee. May, 2016


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Member Review Committee, Joint Program Initiative on Antimicrobial Resistance, European Union. Jan 2017 - Present NIH Antimicrobial Resistance Leadership Group. Publications Committee. Sept 2017 – December 2019 Vice-Chair and Chair, IDWEEK. Infectious Diseases Society of America June 2018 NIH-NIAID Drug Development and Mechanisms of Antibiotic Resistance Study Section (DDR) Ad Hoc Reviewer

SERVICE ON THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON COMMITTEES AND HOSPITALS

Apr 2008 – Present Associate Member Center for Clinical and Translational Sciences The University of Texas Health Science Center at Houston October, 2011 – 2014 Elected Member, Faculty Senate Co-Chair, Subcommittee Research/Education Salary Support and Commitment The University of Texas Medical School at Houston Oct 2011- Present Appointed Member, Antibiotic Subcommittee Harris Health Oct 2012 – Sep 2013 Member, Osteomyelitis Task Force Committee Harris Health Oct 2012 – Present Core Faculty, Internal Medicine Residency Program

SPONSORSHIP OF CANDIDATES FOR GRADUATE DEGREE

Julieta Peña, 2000-2002 MS in Medical Microbiology Pontificia Universidad Javeriana, Bogotá, Colombia “Role of the transmembrane domain of the VanT serine racemase in resistance to vancomycin in Enterococcus gallinarum BM4174” Diana Panesso, 2001-2003 MS in Medical Microbiology Pontificia Universidad Javeriana, Bogotá, Colombia “Transcriptional analysis of the vanC gene cluster from constitutive and inducible strains of vancomycin-resistant Enterococcus gallinarum”


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Jinnethe Reyes, 2003-2005 MS in Microbiology Universidad Nacional de Colombia, Bogotá, Colombia, “Genotypic and phenotypic characterization of enterococci and coagulase-negative staphylococci from Colombian hospitals” Diana Panesso, 2006-2010 PhD in Biological Sciences (Summa Cum Laude) Pontificia Universidad Javeriana, Bogotá, Colombia, “Characterization of a hyaluronidase gene of hospital-associated Enterococcus faecium” (Magna Cum Laude) Lorena Diaz, 2008-2013 PhD in Biological Sciences (Cum Laude) Pontificia Universidad Javeriana, Bogotá, Colombia. “Virulence and antimicrobial resistance of Methicillin-Resistant Staphylococcus aureus in the mini-host Drosophila melanogaster” Jinnethe Reyes, 2010 – 2014 PhD in Biological Sciences (Summa Cum Laude) Pontificia Universidad Javeriana, Bogotá, Colombia. “The LiaFSR system and Daptomycin Resistance in Enterococci” Sandra Rincon, 2014- Present PhD student In Molecular Microbiology Universidad El Bosque (PhD program in cooperation with UT-Houston) “LiaR and Daptomycin Resistance” Ayesha Khan, 2015- present PhD in Microbiology and Molecular Genetics, Graduate School of Biological Sciences, UTHealth – UT MD Anderson Cancer Center “LiaX and antimicrobial peptide resistance in E. faecalis” April Nguyen, 2017-present MD/PhD program. UTHealth McGovern Medical School Willliam Shropshire, 2017-present PhD in Public Health, UTHealth School of Public Health Lina P. Carvajal, 2017-present PhD program, Universidad El Bosque, Bogota, Colombia Marie Kasbaum, January 2018-present MPH Candidate UTHealth School of Public Health Catalina Lizarraga, January 2018-present MPH Candidate UTHealth School of Public Health


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SPONSORSHIP OF MEDICAL STUDENTS PRE- AND POSTDOCTORAL FELLOWS AND JUNIOR FACULTY

Maria Camila Montealegre, Jul 2009 – Dec 2009 Pre-doctoral training fellowship Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM) Cali, Colombia Sandra Rincon, Jul 2009 – Jul 2010 Pre-doctoral, Antimicrobial Surveillance Fellowship American Society for Microbiology – Panamerican Association of Health (ASM-PAHO) Jose D. Tafur, Jul 2009 – Jul 2012 Internal Medicine Resident The University of Texas Medical School at Houston Meritxell Salvado, Feb 2010 - March 2010 Post-Doctoral Training Fellowship University of Barcelona, Spanish Society of Clinical Microbiology Maria Fernanda Mojica, Mar 2010 - Aug 2010 Pre-doctoral Training Fellowship Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Cali Colombia Lorena Diaz, Jun 2010 – Dec 2010 Infectious Disease Epidemiology & Surveillance Fellowship 2010 American Society for Microbiology – Panamerican Association of Health (ASM-PAHO) Muniasamy Neerathilingam, PhD. Mar 2010 – Mar 2011 Post-Doctoral fellow The University of Texas Medical School at Houston David Briceño, MD. Jun 2010 - Jul 2010 Laboratory Rotation Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Cali, Colombia Truc (Cecilia) T. Tran, PharmD. Aug 2010 – July 2014 Post-Doctoral Research Fellow Department of Pharmacy, University of Houston Assistant Professor UTHealth McGovern Medical School Jose Munita, MD. July 2010 – July 2016 Infectious Diseases Fellow University of Texas McGovern Medical School at Houston Associate Professor, Clinica Alemana, Universidad de Desarrollo


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William Miller, MD. Feb 2012 – present Internal Medicine/Infectious Disease Fellow (Chief Fellow) Assistant Professor, University of Texas McGovern Medical School at Houston Pranav S, Bhamidipati, June 2012 – Aug, 2012 High-School Student, St John’s School Summer Research Program UTHSC Alejandra Hernandez, March 2013 – July 2013 Research Scholar Centro Internacional de Investigaciones Medicas (CIDEIM) Cali, Colombia Natasha Mehta, July 2013 – Aug 2013 High-School Student, Glenda Dawson Summer Research Program UTHSC Elizabeth P. Gaston, April 2014 – Aug, 2014 Medical Student (MS-1) Summer Research Program UTHSC Morgan Deal, April 2014 – Aug 2014 Medical Student (MS-1) Summer Research Program UTHSC Michelle Li, May- 2014 – April 2015 Medical student (MS-1) Summer Research Program UTHSC Internal Medicine Resident, UTHealth McGovern Medical School Alejandra Londoño, MD. January 2015 – July 2015 Visiting scholar, CIDEIM University of Texas Medical School at Houston Masayuki Nigo, MD. July 2013 – present Infectious Diseases Fellow Assistant Professor UTHealth McGovern Medical School-Houston Bhavart Shukla, MD. July 2013- July 2105 Infectious Diseases Fellow (Chief Fellow) UTHealth McGovern Medical School at Houston Ebore Awani, May-Aug, 2015 Research Summer Program Rice University Bruce Sharp, May-Aug, 2015 Medical Student (MS-1)


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Summer Research Program UTHSC Daniel Smith, MD. July 2015 - present Infectious Diseases Fellow University of Texas Medical School at Houston Parikshit Prayag, MD July 2015 - present Infectious Diseases Fellow University of Texas Medical School at Houston Yi (Irina) Chen, PhD. September 2016 – September 2017 Post-doctoral Associate University of Texas Medical School at Houston German Contreras, MD, MPH. July 2017-Present Medicine-Pediatrics Residency Program UTHealth McGovern Medical School at Houston Sara I. Gomez Villegas, February 2018 Medical Student Universidad de Antioquia, Medellin, Colombia Blake Hanson, PhD. September 2017-present Assistant Professor UTHealth School of Public Health Alejandro De la Hoz, February – March 2018 Medical Student Pontificia Universidad Javeriana, Cali, Colombia Jessi Degani, May – July 2018 Medical Student UTHealth McGovern Medical School at Houston Jessica Porras, May – July 2018 Medical Student Universidad El Bosque, Bogota, Colombia

CURRENT TEACHING ACTIVITIES

Data and Journal Club, Antimicrobial Resistance Every Wednesday, Videoconference with Universidad El Bosque (Bogota, Colombia) and CIDEIM (Cali, Colombia) 15-17 participants (8 UT and 7 Univ El Bosque trainees including PhD scientists and clinicians). Internal Medicine Residency Program Lectures, Core Curriculum (ca. 30 residents) Board Review, Infectious Diseases (ca. 20 residents) Noon Case Conference (Monday noon) (5-20 participants) Infectious Diseases Fellowship Program


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Core Curriculum lectures (10-15 fellows, UT and BCM) Bi-monthly conference on antimicrobial resistance (10-15 participants) ID seminar for rotating team at MHH (2 fellows, 1-2 residents) Microbiology and Molecular Genetics Graduate Program Faculty member, teaching antibiotic resistance lectures in Microbiology and Molecular Genetics I Course (4-5 PhD students) T32 NIH Educational Grant (Steve Norris, PI) Faculty member and member of steering committee PhD Program in Biological Sciences Universidad El Bosque in collaboration with UT Medical School UT-based program coordinator Student Committees - Surabhi Tyagi, MS in Biological Sciences, UT-Houston (2014-2016) - Laura Ortiz, PhD in Microbiology and Molecular Genetics, Baylor College of Medicine (2014-present)

CURRENT GRANT SUPPORT

Agency: National Institutes of Health/NIAID Type of Grant: R01 Dates of Award: Jul 2018 – Jun 2023 Title: “The LiaFSR system and antimicrobial peptide resistance in enterococci” Amount: $ 556,500 Major goals: To dissect the function and mechanism of action of the LiaR-mediated response to DAP and antimicrobial peptides Role: Principal Investigator Agency: National Institutes of Health/NIAID Type of Grant: K08 Dates of Award: Sept 2017 – Aug. 2022 Title: “Role of YxdJK and DAK in the Enterococcal Envelope Stress Response” Amount: $ 48,516 Major goals: To test the hypothesis that that the YxdJK system plays a pivotal role in the cell stress response pathway to both membrane active and cell wall active agents in enterococci, with alterations in DAK contributing to antimicrobial peptide (AMP) resistance. Role: Primary Mentor (Miller, PI) Agency: National Institutes of Health Type of Grant: K24-AI114818 Dates of Award: Jan 2016 – Dec 2020 Title: "POR Program on Genomic Prediction of Antimicrobial


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Resistance in VRE” Amount: $ 157,690 Major goals: Develop a genomic platform to predict susceptibilities in VRE and evaluate the use of such platform in patient infected with these organisms Role: Principal Investigator Agency: National Institutes of Health Type of Grant: R01 Dates of Award: Oct 2017 – Sep 2022 Title: "Mechanisms of Daptomycin and host peptide cross-resistances in S. mitis”. Amount: $ 195,000 Major goals: Investigate the genetic basis and molecular mechanism of rapid development of daptomycin and antimicrobial peptide resistance in S. mitis. Role: Co-investigator (Bayer, A. PI) Agency: National Institutes of Health Type of Grant: R01 Dates of Award: Sep 2015 – Aug 2020 Title: "A pharmacological approach to prevent daptomycin resistance in VRE” Amount: $ 25,958 (UT direct costs) Major goals: Establish daptomycin pharmacodynamic breakpoints and assess the effectiveness of daptomycin and B-lactam combination against VRE. Role: Co-investigator (Rybak, M. PI) Agency: National Institutes of Health Type of Grant: UM1AI104681 Seed Grant (Munita, JM Fowler VG, PI) Dates of Award: Oct 2016 – Sep 2018 Amount: $ 50,000 Title: “VENOUS” (Prospective outcomes of patients with VRE bacteremia) Major goals: To assemble a cohort of patients with VRE bacteremia in major cancer centers in the USA. Role: Mentor Agency: National Institutes of Health Type of Grant: T32 Dates of Award: March 2016 – Feb 2021 Title: " Molecular Bases of Infectious Disease Training Grant” Major goals: Develop a training project on applied basic science on infectious disease in order to train pre and post graduate students Role: Faculty (Norris, S/Koehler, T., PIs) Agency: National Institutes of Health Type of Grant: Mentored Clinical Scientist Research Career


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Development Award K08-AI113317 Dates of Award: April 2015 - March 2020 Amount: $ 138,350 Title: “yycFG and Its Role in Antimicrobial Resistance in Enterococcus faecium" Major Goals: This project seeks to investigate the role of genes controlling cell envelope homeostasis in resistance to daptomycin, one of the last-resort antibiotics, with the objective of optimizing the use of this drug against these bacteria and identify new targets for antibiotic development. Role: Mentor (Tran, TT, PI) Agency: UT Systems Type of Grant: Institutional retention award Dates of Award: March 2016 – March 2018 Amount: $ 2,000,000 Title: UT Translational STARs Award Major goals: Support the infrastructure of the Center for Antimicrobial Resistance and Microbial Genomics (CARMiG). Role: Principal Investigator Agency: Merck Co. (former Cubist pharmaceuticals) Type of Grant: Independent Investigator Initiated Grant Dates of Award: April 2015 – June 2018 Amount: $ 127,540 Title: “In vivo activity of tedizolid against multidrug-resistant enterococci and staphylococci using a murine peritonitis model”. Major Goals: To provide pre-clinical data of the in vivo activity of tedizolid against several multidrug-resistant clinical isolates including linezolid-resistant E. faecalis and staphylococci multidrug-resistant enterococci Role: Co-PI (Singh, KV, PI) Agency: Merck Co. (former Cubist pharmaceuticals) Type of Grant: Independent Investigator Initiated Grant Dates of Award: April 2015 – June 2018 Amount: $ 227,500 Title: “Tedizolid and daptomycin in step down versus continuation therapy against multidrug-resistant enterococci and Staphylococcus aureus (MRSA /VRSA) using a rat infective endocarditis model” Major Goals: o provide pre-clinical data of tedizolid and daptomycin (with or without beta-lactam antibiotics) in step down versus continuation daptomycin therapy against early endocarditis due to i) MRSA (VRSA), ii) E. faecalis, iii) vancomycin-resistant (VRE), ampicillin-resistance (ARE) E. faecium Role: Co-PI (Singh, KV, PI) Agency: Departamento Administrativo de Ciencia, Tecnología e Innovación - COLCIENCIAS and Universidad El Bosque Type of Grant: Basic sciences RFA


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Dates of Award: Dec 2015- Dec 2018 Amount: $ 315.000 Title: “Genomic and transcriptomic analysis of MRSA genetic lineages in Colombia and Latin America" Cod: 130871250417 Major Goals: To determine the genomic evolution and transcriptomic of MRSA in Colombia and Latin America. Role: Co-Investigator (Reyes, J., PI) Agency: UTHealth Type of Grant: UT Health Science Center – Presidential Collaborative Award Dates of Award: Feb 2017- Jan 2019 Amount: $ 100,000 Title: “Genome Wide Association Study of Staphylococcus aureus Bacteremia” Major Goals: To leverage from clinical data and availability of isolates from Latin America cohort in order to develop a metadata framework of potential applicability in clinical practice of bacterial genomic information. Role: N/A Agency: Texas Medical Center Health Policy Institute Funding Program Type of Grant: TMC Collaborative award Dates of Award: 01/01/2018 – 12/31/2018 Amount: $ 200,000 Title: “Surveillance of Multidrug-Resistant Emerging Healthcare Pathogens” Major Goals: To establish a real-time surveillance system for Candida species isolated from hospitalized patients with bloodstream infection from hospitals in the Texas Medical Center and surrounding Houston hospitals.

PENDING GRANT SUPPORT

Agency: National Institutes of Health/NIAID Type of Grant: T32 Dates of Award: Sep 2018 – Aug 2023 Title: “Texas Medical Center Training Program in Antimicrobial Resistance” Amount: $1,217,632 Major goals: To provide a multidisciplinary, cutting-edge training program on AMR that has a strong transltional component with the ultimate goal of influencing patient care. Role: Principal Investigator Priority score: 20 Agency: National Institutes of Health/NIAID Type of Grant: R21 Dates of Award: Jul 2017 – Nov. 2022 Title: “The cefazolin inoculum effect: a translational approach” Amount: $ 567,942 Major goals: To test the hypotheses that a) the CzlE is primarily


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mediated by the amount of β-lactamase released into the extracellular milieu, b) the ability to hydrolyze cefazolin effectively depends on the affinity of the enzyme isotype for the drug and is a contributor of the CzlE and c) innovative therapeutic interventions could be designed to overcome the CzIE and improve outcomes of severe MSSA infections Role: Principal Investigator Priority score: 20

PREVIOUS GRANT SUPPORT

Federal and Governmental Agency: The Wellcome Trust, UK Type of Grant: International Development Award Dates of Award: Jan 2000 – Jan 2002 Amount: $ 66,000 Title: “Functional and structural studies on VanT: a serine racemase necessary for vancomycin resistance in enterococci" Major Goals: The goal of this project was to characterize the function of the transmembrane domain of a novel serine-racemase necessary for vancomycin resistance in Enterococcus gallinarum. Role: Principal Investigator Agency: COLCIENCIAS (Colombian Institute for Development of Science and Technology) Type of Grant: Research Grant Dates of Award: Sep 2002 – Sep 2004 Amount: $ 73,000 Title: "Resistance to macrolides and fluroquinolones in Gram-positive cocci from Colombian hospitals" Major Goals: The goal of this project was to identify and characterize resistant determinants of macrolide and quinolone antibiotics in clinical isolates of enterococci, staphylococci and pneumococci from Colombian hospitals collected in the last five years Role: Co-Investigator (Castañeda, E, PI) Agency: COLCIENCIAS (Colombian Institute for Development of Science and Technology) Type of Grant: Research Grant Dates of Award: Jul 2003 – Jul 2004 Amount: $94,000 Title: "Evaluation of the antimicrobial activity of vancomycin in clinical isolates of enterococci using primary cultures of endothelial cells" Major Goals: The goal of this project was to develop a model of enteroccocal infection in primary cultures of endothelial cells and evaluate the effect of antibiotics on adherence and intra-cellular bacterial viability Role: Co-Investigator (Fontanilla, M. PI)


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Agency: National Institutes of Health Type of Grant: K99 -AI072961 “NIH Pathway to Independence Award” Dates of Award: Jun 2008 – May 2009 Amount: $90,650 Title: "Enterococcus faecium virulence: A molecular and therapeutic approach” Role: Principal Investigator Agency: National Institutes of Health Type of Grant: R00 -AI072961 “NIH Pathway to Independence Award” Dates of Award: Aug 2009 – Jul 2012 (no cost extension) Amount: $498,000 Title: "Enterococcus faecium virulence: A molecular and therapeutic approach” Major goals: Define the contribution of a gene encoding a hylauronidase protein in virulence in E. faecium and evaluate an antibiotic-antibody approach based on virulence determinants in the treatment of infections caused by E. faecium Role: Principal Investigator Agency: National Institutes of Health Type of Grant: ARRA Supplement R00 -AI072961 Dates of Award: Aug 2010 – Jul 2011 Amount: $95,267 Title: "Enterococcus faecium virulence: A molecular and therapeutic approach” Role: Principal Investigator Agency: John S Dunn Foundation Collaborative Research Award Type of Grant: Collaborative, Rice University Dates of Award: Jan 2011 – Jan 2012 Amount: $ 100,000 Title: "Structural determination of novel targets identified from a multi-drug resistant pathogen” Major goals: To investigate the role of mutations of two genes involved in phospholipid metabolism and one gene responsible for cell wall homeostasis in the development of daptomycin resistance in enterococci Role: Co-Investigator (Yousif Shamoo, PI) Agency: Veterans Hospital Administration Type of Grant: Research Seed Grant Dates of Award: Sep 2011 – Aug 2013 Amount: $50,000. No salary support Title: “Optimizing the management of enterococcal bacteriuria” Major Goals: i) Determine the key social norms and cognitive biases leading to overtreatment of enterococcal asymptomatic bacteriuria that can be targeted in an intervention, and ii)


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prospectively determine the rate of subsequent enterococcal infections occurring after enterococcal bacteriuria Role: Co-Investigator (Trautner, B, PI) Agency: National Institutes of Health Type of Grant: R21-AI092055 Dates of Award: Sep 2011 – Aug 2013 Amount: $ 275,000 Title: “Impact on daptomycin dose exposure on enterococci and characterization of resistance” Major goals: Evaluate the efficacy of different daptomycin dose regimens against vancomycin-resistant enterococci using an in vitro model of simulated endocardial vegetations. Role: Co-Investigator (Rybak, M., PI) Agency: Forest Research Institute (Actavis) Type of Grant: Independent Investigator Initiated Grant Dates of Award: Sep 2014 – Sep 2016 Amount: $ 151,521 Title: “Efficacy of the combination of daptomycin plus ceftaroline against enterococci in a rat model of endocarditis" Major Goals: The goal of this project is to determine the in vivo effectiveness of the combination of daptomycin and ceftaroline against multidrug-resistant E. faecium. Role: Co-Principal investigator Agency: MD Anderson Cancer Center Type of Grant: UTMDA Sister Institutions Fund Dates of Award: Sept 2015 - Aug 2016 Amount: $ 100,000 Title: “Genomic characteristics of VRE bloodstream infection in patients with hematological malignancies: Impact on clinical outcomes in 6 geographical regions" Major Goals: To determine the molecular phylogenomics of VRE isolates from bloodstream infection around the MDACC sister institutions. . Role: Co-Investigator (J. Adachi, S. Shelburne, PIs). Agency: National Institutes of Health Type of Grant: R21- AI114961-01 Dates of Award: July 2015 – May 2017 Title: "Characterization of LiaR from E. faecium” Amount: $ 164,494 Major goals: Biochemical and genetic characterization of the response regulator LiaR with the rationale that it could become a target for anti-adaptation antibiotics. Role: Principal Investigator Agency: National Institutes of Health Type of Grant: R01- AI093749 Dates of Award: Jul 2011 – Jun 2017


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Amount: $286,659 (NCE) Title: "Molecular mechanisms of resistance to daptomycin in enterococci” Major goals: To elucidate the mechanism of resistance to the lipopeptide antibiotic daptomycin and design strategies to prevent the emergence of daptomycin resistance in vivo Role: Principal Investigator Agency: National Institutes of Health Type of Grant: R21/R33 AI121519 Dates of Award: Oct 2015 – Apr 2020 Title: "Targeting cell membrane adaptation in Enterococcus faecium” Amount: $ 77,182 Major goals: Develop small molecule approach to characterize inhibitors of LiaR that could enhance the bactericidal activity of DAP. Role: Principal Investigator Agency: Mike Hogg Foundation Type of Grant: Mike Hogg Seminar Series Dates of Award: Sept 2016- Dec 2017 Amount: $ 8.400 Title: “Mike Hogg Antimicrobial Resistance Research Seminar Series” Major Goals: To support the Mike Hogg Seminar Series to represent regular interinstitutional venue for antimicrobial resistance researchers to gather and brainstorm novel approaches to challenges in antibiotic resistance. Role: N/A Agency: National Institutes of Health Type of Grant: UM1AI104681 (Fowler VG, PI) Dates of Award: Jul 2016 – Nov 2017 Amount: $ 12,987 Title: “Consortium on Resistance Against Carbapenems in Klebsiella pneumoniae and other Enterobacteriaceae: a Prospective, Observational Cohort Study Major goals: To gain better understanding of the molecular epidemiology and dissemination of carbapenems in Klebsiella pneumoniae and other Enterobacteriaceae in the Houston metropolitan area Role: Site Investigator Pharmaceutical Agency: Pharmacia, Inc. Type of Grant: Independent Investigator Initiated Research Grant Dates of Award: May 2001 – May 2002 Amount: $ 50,000


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Title: "Surveillance of antimicrobial resistance in staphylococci and enterococci from Colombian hospitals" Major Goals: The goal of this project was to perform a systematic country-wide surveillance of antibiotic resistance in enterococci and staphylococci to identify potential problems. This was the first systematic surveillance of antimicrobial resistance carried out in Colombia Role: Principal Investigator Agency: Pfizer. Inc Type of Grant: Independent Investigator Initiated Research Grant Date of Award: Nov 2005 – May 2008 Amount: $ 80,000 Title: “Surveillance of antimicrobial resistance in Staphylococcus aureus and enterococci from Colombian, Peruvian, Venezuelan and Ecuadorian hospitals” Major Goals: Characterize patterns, genetic relationship and mechanisms of resistance in Staphylococcus aureus and enterococci from Latin American countries in a multi-center surveillance program Role: Principal Investigator Agency: Pfizer Inc Type of Grant: Independent Investigator Initiated Research Grant Dates of Award: March 2010 – Sep 2012 Amount: $70,884 Title: “Evaluation of MRSA pathogenesis and linezolid resistance in Drosophila melanogaster” Major goals: To develop an insect model for the study of antimicrobial resistance and pathogenesis of methicillin-resistant Staphylococcus aureus (MRSA) Role: Principal Investigator Agency: Pfizer, Inc Type of Grant: Educational Dates of Award: Feb 2011 – Jun 2012 Amount: $143,498 Title: “Latin American antibiotic resistance and medical mycology workshop” Major Goals: provide training on the clinical and laboratory aspects of antimicrobial resistance and medical mycology to Latin American infectious disease specialists and microbiologists Role: Principal Investigator Agency: Pfizer, Inc Type of Grant: Independent Investigator Initiated Research Grant Dates of Award: Jul 2011 – Aug 2014 Amount: $80,000. No salary support Title: “Outcomes of Staphylococcus aureus bacteremia in Latin America” Major Goals: i) Prospectively determine the clinical outcomes of


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S. aureus bacteremia in 27 hospitals of Latin America ii) Study the molecular epidemiology of S. aureus in Latin America Role: Co-Investigator (Gotuzzo, E. PI) Agency: Theravance, Inc Type of Grant: Independent Investigator Initiated Grant Dates of Award: Jun 2012 – May 2015 Amount: $ 148,200 Title: “Efficacy of telavancin in the treatment of E. faecalis experimental endocarditis in a rat model" Major Goals: The goal of this project is to determine the in vivo effectiveness of telavancin or telavancin combinations against ampicillin-susceptible E. faecalis in experimental endocarditis Role: Co-Principal Investigator (Singh, PI)

PUBLICATIONS

A. ABSTRACTS 1. ARIAS, CA., Merino, N., Pacheco, G., Quintero, G., and Escallon, J.. Microbiological

profiles at Fundación Santa Fé de Bogotá. p.p. 64 In Abstracts of the XIX Annual Meeting, Colombian Society for Surgery: Advances in Surgery. Santa fe de Bogota, Colombia (1993).

2. ARIAS, CA., Arroyo, S., Cuervo, J., Quintero, G.A. and Escallon, J. Surgical wound infection at the Fundacion Santa Fe de Bogota. p.p 62. In Abstracts of the XIX Annual Meeting, Colombian Society for Surgery: Advances in Surgery. Santa fe de Bogota, Colombia (1993).

3. ARIAS, CA., Cuervo, J., Quintero, G.A., Escallon, J and Arroyo, S. Surveillance of surgical wound infection. A comprehensive model. p.p. 63 In Abstracts of the XIX Annual Meeting, Colombian Society for Surgery: Advances in Surgery. Santa fe de Bogota, Colombia (1993).

4. ARIAS, CA., Cuervo, J., Quintero, G.A., and Escallon, J. (1993) Prophylaxis in clean surgery. In Abstracts of the XIX Annual Meeting, Colombian Society for Surgery: Advances in Surgery. Santa Fe de Bogota, Colombia.

5. ARIAS, CA., Quintero, GA., Guzman, Y., and Escallon, J. Immunological disturbances in laparoscopic cholecistectomy and prophylaxis with cefodizime. p.p. 55. In Abstracts of the XX Annual Meeting, Colombian Society for Surgery: Advances in Surgery. Santa Fe de Bogota, Colombia (1994).

6. Hall, LMC., Whiley, R., Duke, B., Efstratiou, A., Maskell, J.P., and ARIAS, CA. Genetic Relationships among UK invasive pneumococci of common serotypes with preliminary data on dihydropteroate synthase and capsule synthesis genes. p.p. 9. In Abstracts of the Third European Meeting on the Molecular Biology of The Pneumococcus. Leicester, UK (1995).

7. ARIAS, CA., and Hall, LMC. Capsule locus polymorphism and antibiotic resistance in Streptococcus pneumoniae. In Abstracts of 1st European Congress of Chemotherapy, International Society for Chemotherapy. Glasgow, UK (1996).


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8. ARIAS, CA., and Hall, LMC. Sequence heterogeneity in the capsule production locus of Streptococcus pneumoniae. In Abstracts of the 13th Lancefield International Symposium on Streptococci and Streptocococcal Diseases. Institut Pasteur, Paris. France (1996).

9. ARIAS, CA., Reynolds, PE., and Courvalin, P. Vancomycin resistance in Enterococcus gallinarum requires the presence of a transmembrane protein that converts L-serine to D-serine. In Abstracts for the 2nd European Congress of Chemotherapy and 7th Biennial Conference on Anti-infective Agents and Chemotherapy. Hamburg, Germany (1998).

10. Hall, LMC., ARIAS, CA., Lawrence, ER., Broughton, K., Efstratiou, A., George, R.C. Strategies for DNA-based serotype surveillance in Streptococcus pneumoniae. In Abstracts of The First Symposium on Pneumococci and Pneumococcal Diseases. Alsinore, Denmark (1998).

11. Reynolds, PE., ARIAS, CA., and Courvalin, P. The vanC operon of Enterococcus gallinarum BM4174: Sequencing of vanXYC and characterization of the protein product as a D,D-peptidase/D,D,carboxypeptidase. Abstr C-85 p.93. In Abstracts of the 38th Inter-science Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA American Society for Microbiology, Washington D.C. (1998).

12. ARIAS, CA., and Reynolds, PE. The vanC gene cluster of vancomycin resistant Enterococcus gallinarum BM4174. Abstr C-84 p.93. In Abstracts of the 38th Inter-science Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA American Society for Microbiology, Washington D.C (1998).

13. ARIAS, CA., Weisner, J., Blackburn, J., and Reynolds, P.E. Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174. Abstr 1448 p.130. In Abstracts of the 39th Inter-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Washington D.C. (1999).

14. Arias, CA., Panesso, D., and Reynolds, PE. Sequence and functional analysis of the VanRC-VanSC two component regulatory system in Enterococcus gallinarum BM4174. Abstract 51.001. p.p. 121. In Abstracts of the 9th Congress of the International Society for Infectious Diseases, Buenos Aires, Argentina (2000).

15. ARIAS, CA., Panesso, D, and Reynolds, PE. The VanRC-VanSC two-component regulatory system in Enterococus gallinarum. In Abstracts of the 1st American Society for Microbiology Meeting on Enterococci, Banff , Canada (2000).

16. Ambur, CA., Reynolds, PE., ARIAS, CA. Three ligase genes in vancomycin-resistant Enterococcus gallinarum. Characterization of a D-Ala:D-Ala ligase gene flanking the vanC cluster. Abstract P487, p.77. In Abstracts of the 11th European Congress of Clinical Microbiology and Infectious Diseases, Istanbul, Turkey (2001).

17. ARIAS, CA., Reyes, J., Rico, CL., Cortés, L., Cruz, C., Yepes, F., Peña, A., Zuñiga, M and the RESCOL group. Surveillance of antimicrobial resistance in staphylococci and enterococci: a multi-centric study in Colombian hospitals. p. 35. In Abstracts of the 1st International Symposium on Antimicrobial Resistance, Cartagena, Colombia (2001).

18. Hidalgo, M., Castañeda, E., ARIAS, CA. Tolerance to Vancomycin in a Multi-Resistant Colombian Isolate of Streptococcus pneumoniae. p.35. In Abstracts of the 1st International Symposium on Antimicrobial Resistance, Cartagena, Colombia (2001).

19. Panesso, D., Ospina, S., Robledo, J., Vela, MC., Peña, J., Hernandez, O., Reyes, J., Mejía, GI., ARIAS, CA. First characterization of a cluster of VanA-type vancomycin-


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resistant Enteroccoccus faecium in a Colombian hospital. p. 32. In Abstracts of the 1st International Symposium on Antimicrobial Resistance, Cartagena, Colombia (2001).

20. ARIAS, CA., Reyes, J., Cortes, L., Rico, CL., Cruz, C., Yepes, F., Peña, A., Zuñiga, M., RESCOL group. A Multi-Centric Surveillance of Antimicrobial Resistance in Staphylococci and Enterococci in Colombian Hospitals. 4th European Congress of Chemotherapy, Paris, France. International Journal of Antimicrobial Agents 19:S8 (2002).

21. ARIAS, CA., Peña, J., Reynolds, PE. Function of the transmembrane domain of VanT serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174 4th European Congress of Chemotherapy, Paris, France. International Journal of Antimicrobial Agents 19:S4 (2002).

22. Reyes, J., Zuñiga, M., and ARIAS, CA. Macrolide resistance genes in Staphylococcus aureus and coagulase negative staphylococci from Colombian hospitals. Abstr C2-1988 p.123. In Abstracts of the 42th Inter-science Conference on Antimicrobial Agents and Chemotherapy. San Diego, CA. American Society for Microbiology. Washington D.C. (2002).

23. Villegas, MV., Reyes, J., ARIAS, CA, Correa, A., and Quinn J. Isolation of fluoroquinolone resistant Escherichia coli from poultry and humans in Colombia. Abstr 88, p. 60. In Abstracts of the 40th Infectious Disease Society of America Annual Meeting, Chicago, IL. (2002).

24. Reyes, J., Diaz, L., Vanegas, N., Hidalgo, M., Moreno, J., Castañeda, E., and ARIAS, CA. Characterization of macrolide resistance in pneumococci, staphylococci and enterococci from Colombian hospitals: A country-wide surveillance. Abstr 431, p. 114. In Abstracts of the 43rd Infectious Disease Society of America, Annual Meeting. San Francisco, CA. (2005).

25. Cruz, C., Moreno, J., Hidalgo, M., Castañeda, E., Renzoni, A., Schrenzel, A., Lew, D., Reyes, J., ARIAS, CA. Tracking Methicillin-Resistant Staphylococcus aureus (MRSA) Clones in Colombian Hospitals during Seven Years (1996-2003): Emergence of a New Dominant Clone. Abstr 511, p.131. In Abstracts of the 43rd Infectious Disease Society of America, Annual Meeting. San Francisco, CA. (2005)

26. Rincon, S., Cortes, F., Diaz, L., Cortes, L., Reyes, J., Vanegas, N., and ARIAS, CA. Ciprofloxacin-resistant E. coli (CREC) in chicken fecal samples and retail poultry meat in Bogotá, Colombia. Abstr 501, p.129. In Abstracts of the 43rd Infectious Disease Society of America, Annual Meeting. San Francisco, CA. (2005)

27. ARIAS, CA., Cortes, L., Murray, BE.. Correlation between chain length, gelatinase (GelE) phenotype and the presence of gelE and fsrB in clinical isolates of Enterococcus faecalis. In Abstracts of the 45th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Abstr K-2112. p.378 Washington D.C. American Society for Microbiology (2005).

28. ARIAS, CA., Singh, KV., Murray, BE. Evaluation of ceftobiprole in a mouse model of peritonitis including a Bla + strain. In Abstracts of the 45th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Abstr B-1125. p.48 San Francisco CA. American Society for Microbiology (2006).

29. ARIAS, CA., Villegas, MV., Reyes, J., Moreno J., Xiong, L., Vallejo, M., Lolans, K., Mankin, A., Castaneda, E., Quinn, JP.. Linezolid resistance in the absence of 23S rRNA mutations. In Abstracts of the 45th Inter-Science Conference on Antimicrobial Agents and


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Chemotherapy. Abstr C2-1147. p.125. San Francisco CA. American Society for Microbiology (2006).

30. ARIAS, CA., Panesso, D., Singh, KV., Rudin, S., Rice, LB., Murray, BE.. A hyaluronidase-like gene deletion mutant of Enterococcus faecium is attenuated in vivo. In Abstracts of the 47th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Abstract B-56. p.37. Chicago IL, American Society for Microbiology (2007).

31. Rincón, S., Martínez, E., Díaz, L., Reyes, J., Panesso, D., Murray, BE., ARIAS, CA. Dissemination of community-associated methicillin resistant Staphylococcus aureus USA 300, sequence type 8 in Colombia. In Abstracts of the 47th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Abstract C2-145. p.101. Chicago IL, American Society for Microbiology (2007).

32. Chowdhury, S., ARIAS, CA., Nallapareddy, S., Murray, BE. A tri-locus sequence typing (TLST) scheme based on antigenic genes discriminates evolutionary relationships in Enterococcus faecalis. In Abstracts of the 47th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Abstract C2-130. p.97. Chicago IL, American Society for Microbiology (2007).

33. Panesso, S., Reyes, J., Zurita, J., Carrillo, C., Guzmán, M., Rincón, S., Díaz, L., Contreras, GA., Adachi, JA., Chowdhury, S., Murray, BE., ARIAS, CA. Molecular Characterization of vancomycin-resistant enterococci (VRE) from Latin-American hospitals: A prospective study, 2006-2007. In Abstracts of the Joint 48th Inter-Science Conference on Antimicrobial Agents and Chemotherapy and 45th Annual Infectious Disease of America Abstract C2-1998. p.189. Washington DC, American Society for Microbiology and Infectious Disease Society of America (2008).

34. Panesso, D., Bourgogne, A., Singh, KV., Murray, BE., ARIAS, CA. Directed mutagenesis in Enterococcus faecium (Efm) using the PheS* vector system. In Abstracts of the Joint 48th Inter-Science Conference on Antimicrobial Agents and Chemotherapy and 45th Annual Infectious Disease of America Abstract B-074. p.47. Washington DC, American Society for Microbiology and Infectious Disease Society of America (2008).

35. Reyes, J., Rincón, S., Díaz, L., Panesso, D., Contreras, G., Zurita, J., Carrillo, C., Guzmán, M., Adachi, J., Chowdhury, S., Murray, BE., ARIAS, CA. Molecular epidemiology of MRSA in Latin-American hospitals: A prospective study, 2006-2008. In Abstracts of the Joint 48th Inter-Science Conference on Antimicrobial Agents and Chemotherapy and 45th Annual Infectious Disease of America Abstract C2-219. p.153. Washington DC, American Society for Microbiology and Infectious Disease Society of America (2008).

36. Contreras, GA., DiazGranados, CA., Cortes, L., Reyes, J., Vanegas, S., Panesso, D., Rincón, S., Díaz, L., Prada, G., Murray, BE., ARIAS, CA. Nosocomial outbreak of Enteroccocus gallinarum: Untaming of rare species of enterococci. In Abstracts of the Joint 48th Inter-Science Conference on Antimicrobial Agents and Chemotherapy and 45th Annual Infectious Disease of America Abstract K-901. p.473. Washington DC, American Society for Microbiology and Infectious Disease Society of America (2008).

37. Bourgogne, A., Garcia, D., Murray, BE., ARIAS, CA. Transcriptome analysis of a daptomycin-resistant strain of Enterococcus faecalis. In Abstracts of the 49th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, American Society for Microbiology. Abstract C1-614 (2009).

38. Galloway-Pena, J., Nallapareddy, SR, ARIAS, CA., Murray, BE. Analysis of clonality and emergence of ampicillin resistance among early and recent Enterococcus faecium in the


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United States. In Abstracts of the 49th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, American Society for Microbiology. Abstract C2-1896 (2009).

39. Panesso, D., Singh, KV., Murray, BE., ARIAS, CA. Role of a Enterococcus faecium (Efm) hylEfm-containing plasmid in the pathogenesis of mouse urinary tract infection. In Abstracts of the 49th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, American Society for Microbiology. Abstract, B-1089 (2009).

40. Watson, CC., Ben-Ami, R., ARIAS, CA., Raad, II., Lewis, RE., Kontoyiannis, D. A study of the role of Panton-Valentine leukocidin in methicillin-resistant Staphylococcus aureus virulence using wild-type and Toll-deficient Drosophila melanogaster. In Abstracts of the 47th Annual Meeting of the Infectious Disease Society of America. Philadelphia, PA, Infectious Disease Society of America. Abstract, 1333 (2009).

41. McGrath, D., Barbu, E., Pasqualini, R., Arap, R., Quinn, JP., Murray, BE., ARIAS, CA. Resistance to daptomycin in vancomycin-resistant Enterococcus faecalis is associated with alterations of cell membrane (CM) potential and surface charge. In Abstracts of the 50th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Boston, MA. American Society for Microbiology. Abstract C1-078 (2010).

42. McGrath, D., Barbu, E., Pasqualini, R., Arap, R., Quinn, JP., Murray, BE., ARIAS, CA. Transmission electron microscopy of daptomycin-susceptible Enterococcus faecalis and its daptomycin-resistant derivative that arose during therapy. In Abstracts of the 50th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Boston, MA. American Society for Microbiology. Abstract C1-079 (2010).

43. Tafur, JD., Panesso, D., Singh, KV., Mojica, MF., Murray, BE., ARIAS, CA. The hylEfm-containing plasmid increases the virulence of Enterococcus faecium in rat endocarditis. In Abstracts of the 50th Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Boston, MA. American Society for Microbiology. Abstract B-1409 (2010).

44. ARIAS, CA. Use of whole genome sequence to track the in vivo evolution of antimicrobial resistance in enterococci. In Abstracts of Infectious Disease genomics and Global Health Meeting. Joint Cold Spring Harbor Laboratory/Wellcome Trust Conferences. Hinxton, Cambridge, UK (2010).

45. ARIAS, CA., Albert, N., Diaz, L., Watson, C., Murray, BE., Kontoyiannis, D. Evaluation of the in vivo role of cfr in linezolid (Lnz) resistance using the Drosophila melanogaster model of Staphylococcus aureus (Sa) infection. In Abstracts of the 48th Infectious Disease Society of America. Vancouver, BC, Canada. Infectious Disease Society of America. Abstract 258 (2010).

46. ARIAS, CA., Qin, X., Lobos, E., Sodergren, E., Quinn, JP., Reyes, J.,Murray, BE., Weinstock,G. Whole-genome analysis of daptomycin-susceptible Enterococcus faecalis and its daptomycin-resistant derivative that arose during therapy. In Abstracts of the 48th Infectious Disease Society of America. Vancouver, BC, Canada. Infectious Disease Society of America. Abstract 245 (2010).

47. Reyes, J., Díaz, L., Berrío, M., Rincón, S., Duarte, E., Carvajal, LP., Pérez, K., Moreno, J., Rodríguez, ND., ARIAS, CA. Mechanisms of antimicrobial resistance in Community-Associated (CA)-MRSA USA300 Variant from South America. In Abstracts of the 48th Infectious Disease Society of America. Vancouver, BC, Canada. Infectious Disease Society of America. Abstract 319 (2010).


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48. Tran, TT., Mishra, NN., Mcgrath, DM., Bayer, AS., ARIAS, CA. Cell membrane depolarization-permeabilization, surface charge and aminophospholipid flipping in a clinical daptomycin-susceptible and -resistant Enterococcus faecium strain-pair. In Abstracts of the 51st Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. American Society for Microbiology. Abstract C1-1774 (2011).

49. Hall, AD, Steed, ME., ARIAS, CA., Murray, BE., Rybak, MJ. Evaluation of standard and high dose daptomycin versus linezolid against vancomycin-resistant enterococci in an in vitro model of simulated endocardial vegetations (SEV). In Abstracts of the 51st Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. American Society for Microbiology. Abstract A2-018 (2011).

50. Tran, TT., Lewis, CT., Jaijakul, S., Diaz, SL., Murray, BE., Wanger, A., Kaplan, HB., ARIAS, CA. Heterogeneous resistance to daptomycin (DAP) in Corynebacterium striatum causing endocarditis: collateral damage from DAP therapy. In Abstracts of the 51st Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. American Society for Microbiology. Abstract K-1905 (2011).

51. Diaz, L., Kontoyiannis, DP., Albert, N., Panesso, D., Singh, KV., Tran, TT., Murray, BE., ARIAS, CA. In Vivo Evaluation of Different Mechanisms of Linezolid (Lnz) Resistance Using a Staphylococcus aureus (Sa) Mini-Host Model. In Abstracts of the 51st Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL. American Society for Microbiology. Abstract C1-1781 (2011).

52. Steed, ME., ARIAS, CA., Murray, BE., Rybak, MJ. Evaluation of standard and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus faecalis in an in vitro model of simulated endocardial vegetations. 22nd European Congress of Clinical Microbiology and Infectious Diseases, London, UK (2012).

53. Munita, JM., Panesso, D., Diaz, L., Tran, TT., Reyes, JC., Wanger, A., ARIAS, CA. Is daptomycin susceptibility breakpoint appropriate for enterococci? 22nd European Congress of Clinical Microbiology and Infectious Diseases, London, UK (2012).

54. Diaz, L., Kiratisin, P., Mendes, R., Panesso, D, Singh, KV, ARIAS, CA. Transferable Plasmid-Mediated Resistance to Linezolid Due to cfr in a Human Clinical Isolate of Enterococcus faecalis. 22nd European Congress of Clinical Microbiology and Infectious Diseases, London, UK (2012).

55. Rincon, S., Reyes, J., Caravajal, LP., Murray, BE., Nannini, EC., ARIAS, CA. Cefazolin high-inoculum effect in methicillin-susceptible S. aureus (MSSA) from South American (SA) hospitals. In Abstracts of the 52nd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Abstract C2-1389 (2012).

56. Munita, JM., Tran, TT., Panesso, D., Diaz, SL., Reyes, J., Murray, BE., ARIAS, CA. Mutations in LiaF abolish the bactericidal activity of daptomycin against E. faecalis. In Abstracts of the 52nd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Abstract C1-1345 (2012).

57. Reyes, J., ARIAS, CA., Rincon, S., LP, Carvajal., N, Rojas., Ibarra, G., Garcia, C., Alvarez, CA., Guzman, M., Seas, C., Gotuzzo, E. MRSA USA300 variant has replaced the Chilean clone in Latin American hospitals. In Abstracts of the 52nd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Abstact C2-1909 (2012).


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58. Seas, C., Garcia, C., Zurita, J., Alvarez, CA., Guzman, M., Reyes, J., ARIAS, CA., Gotuzzo, E. Clinical outcomes of Staphylococcus aureus bloodstream infections in Latin America: A prospective multicenter study. In Abstracts of the 52nd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Abstract K-900 (2012).

59. Tran, TT., Panesso, D., Gao, H., Roh, J., Munita, JM., Reyes, J., Diaz, L., Lobos, EA., Shamoo, Y., Mishra, NN., Bayer, AS., Murray, BE., Weinstock, GM., ARIAS, CA. Whole-genome analysis of a daptomycin-susceptible Enterococcus faecium and its daptomycin-resistant variant arising during therapy. In Abstracts of the 52nd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. American Society for Microbiology. Abstract C1-1351b (2012).

60. Correa, A.,del Campo, R., Perenguez, M., Maya, JJ., Rodríguez-Baños, M., Canton, E., ARIAS, CA., Quinn, JP., Villegas., MV. Widespread Pseudomonas aeruginosa ST 111-VIM and ST-235-KPC clones in clinical settings from Colombia. In Abstracts of the 23nd European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany. Abstract 2587 (2013).

61. Diaz, SL., Rincon, S.,Rojas, NL., L. Carvajal, LP., Reyes, J.,Tran, TT., Panesso, Munita, JM., Weinstock, GM., ARIAS, CA. Mutational Analyses of Enterococcus faecium (Efm) With Diverse Daptomycin (DAP) MICs Using Whole Genome Sequencing (WGS). In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver. Abstract C1-313(2013).

62. Tran, TT., Panesso, D., Diaz, SL., Munita, M., , Reyes, J., Murray, BE., ARIAS, CA. A LiaFSR-Independent Pathway to Daptomycin (DAP) Resistance in Enterococcus faecium. In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver. Abstract C1-314 (2013).

63. Munita, JM., Miller, WR.,Tran, TT., Panesso,D., Diaz, SL., Reyes, J., ARIAS, CA. Mutations in liaSR Abolish the Bactericidal Activity of Daptomycin (DAP) Against DAP-Susceptible, Vancomycin-Resistant E. faecium (VRE). In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver, CO. Abstract C1-315 (2013).

64. Munita,JM., Alvarez, D., Bayer, AS., Panesso, D., Tran, TT., Reyes, J., Adachi, JA., Mishra, N., ARIAS, CA. Mutations in LiaSR in Vancomycin-Resistant E. faecium (VRE) Predict Clinical Daptomycin Treatment Failure. In Abstracts of the 53rd,Inter-Science Conference on Antimicrobial Agents and Chemotherapy Denver, CO. Abstract C1-316 (2013).

65. Reyes, J., Panesso, D., Munita,JM., Tran, TT., Wanger, A., Murray, BE., ARIAS, CA. Effect of A Cardiolipin Synthase Mutation on Susceptibility to Cell Envelope-Acting Antibiotics in Enterococcus faecalis (Efs). In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver, CO. Abstract C1-502 (2013).

66. Panesso, D., Munita, JM., Singh, KV., Tran, TT., Reyes, J., Murray, BE., ARIAS, CA. Daptomycin (DAP) Resistance is Associated with Increased Biofilm Formation and Tissue Persistence in Enterococcus faecalis Experimental Endocarditis (EE). In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver, CO. Abstract B-1068 (2013).


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67. Rincon, S., Carvajal, LP., Rojas, NL., Reyes,J., Panesso,D., Rodriguez, JF., Vera, JD., S Ruiz, SD., Diaz, S., Murray, BE., Nannini, EC., ARIAS, CA. Activity of cephalosporins against invasive methicillin-susceptible S. aureus (MSSA) exhibiting cefazolin high-Inoculum Effect (InE). In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy , Denver, CO. Abstract C02-087(2013).

68. Werth, BJ., Steed, ME., Ireland, CE., Tran, TT., ARIAS, CA., Rose, WE., Rybak, MJ. Defining Daptomycin (DAP) Mutant Prevention Exposures in Vancomycin Resistant Enterococcus (VRE) faecium and faecalis. In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy. Denver, CO. Abstract A-020 (2013).

69. Correa, A., Del Campo, R., Perenguez, M., Rodríguez-Baños, M., De La Cadena, E., Rojas, LJ., Canton, R., ARIAS, CA., Quinn, JP., Villegas, MV. High genetic diversity of clinical KPC-producing Klebsiella pneumoniae clones in Colombia. In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver, CO., Abstract C2-1101 (2013).

70. Rossi, F., Diaz, L., Wollam, A., Panesso, D., Zhou, Y., Rincon, S., Narechania, A., G. Xing, G., Di Gioia, TSR., Doi, T., Tan2, TT., Reyes, J., Munita, JM., Carvajal, LP., Hernandez, A., Brandão, D., van der Heijden, IM., Murray, BE., Planet, PJ., Weinstock, GM., ARIAS, CA. Transferable high-level vancomycin resistance in community-associated MRSA genetic lineage. In Abstracts of the 53rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Denver, CO Abstract C2-564d (2013).

71. Panesso, D., Tran, T.T., Munita, JM., Reyes, J., Murray, B.E., ARIAS, CA. Mutations in liaSR of Enterococcus faecium are not associated with remodeling of cell membrane phospholipids. In Abstracts of the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR). Cartagena, Colombia (2014).

72. Carvajal, LP., Diaz, L., Rincon, S., Munita, JM., Amaya, CA, Rojas, N., Morfin-Otero, R., Rodriguez-Noriega, E., Mendes, R.E., Jones, R.N., ARIAS, CA. Cfr-mediated linezolid resistance (LNZ-R) in clinical Enterococcus faecalis from Latin America. In Abstracts of the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR) Cartagena, Colombia (2014).

73. Mishra, N.N., Diaz, L., Bayer, A.S., Yeaman, M.R., Tran, T.T., Panesso, D., Munita, JM., Reyes, J., Murray, B.E., ARIAS, CA. Alterations in the LiaFSR system impact susceptibility to cationic antimicrobial peptides in Enterococcus faecalis. In Abstracts of the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR). Cartagena, Colombia (2014).

74. Tran, T.T., Panesso, D., Diaz, L., Munita, JM., Reyes, J., Rincon, S., Carvajal, L.P., Murray, B.E., ARIAS, CA. Ampicillin (AMP) failed to enhance daptomycin (DAP) activity against an Enterococcus faecium whose DAP resistance develops via a LiaFSR-independent pathway. In Abstracts of the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR). Cartagena, Colombia (2014).

75. Rincon, S., Tran, T.T., Panesso, D., Reyes, J., Nigo, M., Munita, JM., Murray, B.E., ARIAS, CA. Deletion of the response regulator of LiaFSR reverts DAP resistance and cardiolipin (CL) domain redistribution in the cell membrane of E. faecalis. In Abstracts of


31

the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR). Cartagena, Colombia (2014).

76. Reyes, J., Munita, JM., Tran, T.T., Panesso, D., Diaz, L., Murray, B.E., ARIAS, CA. Effect of LiaFSR on the susceptibility to daptomycin (DAP) and cephalosporins of Enterococcus faecalis. In Abstracts of the 4th ASM Conference on Enterococci In conjunction with the 8th International Symposium on Antimicrobial Resistance (ISAR). Cartagena, Colombia (2014).

77. Davlieva, MG., Shi, Y., Zianni, M., Johnson, T., Leonard, P., Ladbury, J., ARIAS, CA., Shamoo, Y. Biochemical and structural characterization of LiaR from vancomycin-resistant E. faecalis: the ‘master regulator’ of the cell-envelope stress response. In Proceedings of the 28th Annual Symposium of the Protein Society. POST 10-96 (2014).

78. Valentini, E., Campi, P., Flynn, L., Toresani, I., Carvajal, L., Reyes, J., Rincon, S., Nannini, ARIAS, CA. Cephalexin failure for the treatment of deep seated methicillin-susceptible Staphylococcus aureus infection: the role of the inoculum effect. In Abstracts of XIV Conference of The Argentinian Society of Infectious Diseases (2014).

79. Reyes, J., ARIAS, CA., Luna, C., Costa-Salles, M., Labarca, J., Garcia, C., Carvajal, LP., Rincon, S., Amaya, C., Seas, C., Gotuzzo, E. Prospective study of the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bacteremia in South America. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract C-810 (2014).

80. Reyes, J., ARIAS, CA., Rodriguez, E., Mejia, C., Carvajal, LP., Rincon, S., Amaya, C., Seas, C., Gotuzzo, E. Molecular typing of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections in Mexico and Guatemala: a prospective study, 2011-2013. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington (ICAAC), DC. Abstract C-811 (2014).

81. Panesso, D., Reyes, J., Londoño, A., Tran, TT., Shamoo, Y., ARIAS, CA. Deletion of liaR reverses daptomycin (DAP) resistance in Enterococcus faecium independent of the genetic background. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract C-2011 (2014).

82. Rincon, S., Carvajal, LP., Reyes, J., Amaya, C., Diaz, L., Planet, PL., ARIAS, CA. SpeG-ACME is absent in methicillin-resistant Staphylococcus aureus USA300 Latin American variant (USA300-LV). In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Abstract C-822 (2014).

83. Singh, KV., Tran, TT., Tam, VH., Murray, BE., ARIAS, CA. Efficacy of telavancin (TLV) alone and in combination with ampicillin (AMP) in an Enterococcus faecalis rat endocarditis model. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Abstract E-221 (2014).

84. Tran, TT., Mishra, NN., Panesso, D., Diaz, L., Munita, JM., Reyes, J., Bayer, AS., ARIAS, CA. Substitutions in YycG and cardiolipin synthase alter cell membrane phospholipids and lead to daptomycin (DAP) resistance in Enterococcus faecium. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Abstract C-833 (2014).

85. Reyes, J., ARIAS, CA., Alvarez, C., Zurita, J., Guzman, M., Carvajal, LP., Rincon, S., Amaya, C., Seas, C., Gotuzzo, E. MRSA USA300 Latin American variant (USA300-LV) has completely replaced other hospital-associated lineages in northern South America. In


32

Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Abstract C-808 (2014).

86. Shukla, B., Chavez, V., Londoño, A., Panesso, D., Munita, JM., Rossi, F., Wanger, A., Tran, TT., ARIAS, CA. vanA stability and population analysis of community-associated (CA) vancomycin-resistant MRSA. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Abstract C-1384 (2014).

87. Palmer, HR., Tran, TT., ARIAS, CA, Cook, GM., Murray, BE. Can oral bacitracin help with vancomycin-resistant Enterococcus faecium bacteremia unresponsive to parenteral therapy? In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract K-1663 (2014).

88. Singh, KV., Tran, TT., Tam, VH., Murray, BE., ARIAS, CA. Efficacy of telavancin alone and in combination with ampicillin (AMP) in an Enterococcus faecalis rat endocarditis model. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract E-221 (2014).

89. Panesso, D., Planet, PJ., Diaz, L., Tran, TT., Hugonnet, JE., Narechania, A., Reyes, J., Rincon, S., Carvajal, LP., Munita, JM., Londoño, A., Murray, BE., Rossi, F., Arthur, M., ARIAS, CA. Methicillin-susceptible and vancomycin-resistant Staphylococcus aureus. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract C-1398b (2014).

90. Tran, TT., Werth, BJ., Diaz, L., Narechania, A., Planet, PJ., Smith, H., Ryan, C., Rybak, MJ., ARIAS, CA. Novel genomic pathways for daptomycin resistance in vancomycin-resistant enterococci selected using a simulated endocardial vegetation model. In Abstracts of the 54rd Inter-Science Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC. Abstract C-1398a (2014).

91. Planet, PJ., Kolokotronis, SE., Narechania, A., Reyes, J., Xing, G., Rincon, S., Smith, H., Panesso, D., Ryan, Ch., Diaz, L., Sebra, R., Nolan, RL., Tenover, FC., Weinstock, GM., Robinson, DA., ARIAS, CA. Pan-American origins of the community-associated USA300 MRSA epidemic. In Abstracts of the 14th International symposium of on staphylococci and staphylococcal infections. Chicago, IL. (2014).

92. Nigo, M., Panesso, D., Reyes, J., Tran, TT., Gaston, E., Deal, M., Londoño, A., Shamoo, Y., ARIAS, CA. A liaR Deletion Restores Daptomycin (DAP) Bactericidal Activity against DAP Resistant and Tolerant E. faecium Strains Independent of the Genetic Background. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego.CA. Abstract C-561 (2015).

93. Miller, W., Díaz, L., Rios, R., Reyes, J., Smith, D., Planet, PJ., Narechania, A., Sebra, R., Deikus, G., Panesso, D., ARIAS, CA. LiaR Independent Genetic Pathways Associated with Daptomycin (DAP) Resistance in Enterococcus faecalis In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego.CA Abstract C-601 (2015).

94. Panesso, D., Tran, TT., Reyes, J., Gaston, E., Deal, M., Londoño, A., Shamoo, Y., ARIAS, CA. Restoring Activity of Daptomycin (DAP) Against DAP-Tolerant strains of Enterococcus faecium (Efm) by targeting the LiaFSR System In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-602 (2015).


33

95. Rincon, S., Carvajal, LP., Ríos, R., Reyes, J., Diaz, L., Panesso, D., Rojas, L., Weinstock, G., Deikus, G., Sebra, R., Alvarez, C., Zurita, J., Guzmán, M., Lun, C., Seas, C., Gotuzzo, E., Planet, PJ., ARIAS, CA. The COMER island involved in copper and mercury resistance in MRSA USA300-Latin American Variant (USA300-LV): a comparative genomic analysis. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-598 (2015).

96. Rios, R., Diaz, L., Reyes, J., Rincon, S., Panesso, D., Carvajal, LP., Munita, JM., Weinstock, G., ARIAS, CA. Vancomycin-Resistant Enterococcus faecium from South-America Belong to a Novel Hospital-Associated Clade. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-604 (2015).

97. Carvajal, LP., ARIAS, CA., Reyes, J., Rincon, S., Rios, R., Diaz, L., Rojas, L., Nacherania, A., Planet, PJ., Weinstock, G., Luna, C., Salles, M., Labarca, J., Alvarez, C., Zurita, J., Mejia C., Rodriguez, E., Garcia, C., Guzman, M., Seas, C., Gotuzzo, E., Latin America Working Group on Bacterial Resistance. Genomic Analysis of Community-Associated (CA)-MRSA Genetic Lineages Causing Bacteremia in South America. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-1035 (2015).

98. Reyes, J., ARIAS, CA., Carvajal, LP., Rincon, S., Rios, R., Diaz, L., Garavito, JD., Castellanos, M., Luna, C., Costa-Salles, M., Labarca, J., Alvarez, C., Zurita, J., Mejia, C., Rodriguez, E., Garcia, C., Guzman, M., Seas, C., Gotuzzo, E., Latin America Working Group on Bacterial Resistance. Genomic Analysis of MRSA Clonal Complex 5 (CC5) Causing Bloodstream Infections in Latin America (LA). In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-1034 (2015).

99. Diaz, L., Reyes, J., Narechania, A., Rios, R., Munita, JM., Tran, TT., Panesso, D., Deikus, G., Sebra, R., Planet, PJ., Bhardwaj, P., Ryan, C., Latorre, M., Palmer, K., ARIAS, CA. Genome-Wide Transcripcional Analysis of LiaFSR-mediated Daptomycin Resistance (DAP-R) in Enterococcus faecalis (Efs). In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-603 (2015).

100. Rojas, LJ., Bonomo, RA., De La Cadena, E., Hanson, B., Hujer, K., Vats, P., Brown, J., Correa, A., Weinstock, E., Weinstock, GM., ARIAS, CA., Villegas, MV. Evolution and heterogeneity of genetic lineages of KPC-producing Klebsiella pneumoniae (KPC-Kpn) in Colombia. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-629 (2015).

101. Singh, KV.,Tran, TT.,Tam, VH.,Murray, BE.,ARIAS, CA. Efficacy of ceftaroline fosamil against methicillin-susceptible Staphylococcus aureus (MSSA) Exhibiting the Cefazolin inoculum effect in experimental endocarditis. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract B-059 (2015).


34

102. Tran, TT.,Singh, KV., Tam, VH., Murray, BE., ARIAS, CA. In vitro activity of ceftaroline against MSSA (Bla type A) inoculum effect and single dose pharmacokinetics study in rats. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract D-1139 (2015).

103. Mishra, NN., Alvarez, DN., Seeprsaud, R., Tran, TT., Garcia de la maria, C., Miro, JM., Rybak, MJ., ARIAS, CA., Sullam, PM., Bayer, AS. Phenotypic and genotypic mechanisms of daptomycin resistance (DAP-R) in Streptococcus mitis. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract C-606 (2015).

104. Smith, JR., Yim, J., Hallesy, JA., ARIAS, CA., Rybak, MJ. B-lactam antibiotics enhance daptomycin activity against vancomycin resistant enterococci in an in vitro biofilm model. In Abstracts of the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy and 28th International Congress of Chemotherapy Meeting (ICAAC/ICC), San Diego CA. Abstract A-488 (2015).

105. Nigo, M., Carvajal, LP., Tran, TT., Rios, R., Munita, JM., Panesso, D., Wanger, A., Diaz, L., ARIAS, CA. Endocarditis caused by MRSA with reduced susceptibility to vancomycin and daptomycin and resistance to ceftaroline: treatment approach and evidence of patient to patient transmission. In Abstracts of IDWeek2015. Infectious Disease Society of America. San Diego CA (2015).

106. Miller, W., Diaz, L., Rios, R., Reyes, J., Smith, D., Narechania, A., Sebra, R., Deikus, G., Panesso, D., Planet, P., ARIAS, CA. LiaR-independent daptomycin (DAP) resistance arises de novo in Enterococcus faecalis but not in E. faecium. In Abstracts of IDWeek2015. Infectious Disease Society of America. San Diego CA (2015).

107. Shukla, BS., Shelburne, S., Reyes, K., Lewis, LD., Rincon, SL., Panesso, D., Adachi, J., Sifri, CD., Zervos, MJ., Munita, JM., Hasbun, R., ARIAS, CA. Influence of MIC in clinical outcomes of Enterococcus faecium bacteremia treated with daptomycin: Is it time to change the breakpoint? In Abstracts of IDWeek2015. Infectious Disease Society of America. San Diego CA (2015).

108. Mishra, NN., Seepersaud, R., Alvarez, DN., Tran, TT., Bensing, BA., Garciade-la-Maria, C., Miro, JM., Rybak, MJ., ARIAS, CA., Bayer, S., Sullam, PM. CDP-diglyceride synthase a mediates high-level daptomycin resistance in Streptococcus mitis. In Abstracts of ASMMicrobe 2016. American Society for Microbiology. Boston, MA (2016).

109. Tran, TT., Garcia de la Maria, C., Mishra, N., Miro, J., Rybak, M., Sullam, P., Bayer, A., ARIAS, CA. Selective binding of antibiotic mediates daptomycin resistance in Streptococcus mitis. In Abstracts of ASMMicrobe 2016. American Society for Microbiology. Boston, MA (2016).

110. Rincon, S., Panesso, D., Latorre, M., Appel, T., Reyes, J., Tran, TT., ARIAS, CA. Transcriptional analysis of the liaFSR cluster in daptomycin-resistant Enterococcus faecalis. In Abstracts of ASMMicrobe 2016. American Society for Microbiology. Boston, MA (2016).

111. Davlieva, M., Tovar-Yanez, A. DeBruler, K. Leonard, P., Zianni, M., ARIAS, CA., Yousif, S. Adaptive mutations in liaR are sufficient to confer daptomycin resistance in Enterococcus faecium by inducing phosphorylation-independent activation of the liaFSR-mediated membrane stress response. In Abstracts of ASMMicrobe 2016. American Society for Microbiology. Boston, MA (2016).

112. Tran, TT., ARIAS, CA., Double β-lactam combination is synergistic against daptomycin-resistant Enterococcus faecium harboring YycFG Substitutions and an intact LiaFSR system. In Abstracts of ASMMicrobe 2016. American Society for Microbiology. Boston, MA (2016).


35

113. Samuel S, Edwards NJ, Rojas LJ, Rudin, SD, Marshall SH, De Cicco I, Bonomo RA, ARIAS, CA, Tran, TT. Ceftazidime-avibactam for the treatment of post-neurosurgical meningitis caused by a KPC-producing Klebsiella pneumoniae. In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

114. Munita JM, Aitken S, Perez F, Rosa R, Jain R, Nigo M, Wanger A, Araos R, Tran TT, Tverdek FP, Shimose L, Lichtenberger P, Adachi J, Abbo L, Rakita R, Shelburne S, Bonomo RA, ARIAS, CA. Ceftolozane-tazobactam (C/T) for severe infections caused by carbapenem-resistant Pseudomonas aeruginosa.. In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

115. Smith D, Singh KV, Tran TT, ARIAS, CA, Murray BE. Daptomycin plus ceftaroline against daptomycin-resistant Enterococcus faecium in a rat model of experimental endocarditis. In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

116. Rada AM, Orozco N, Agudelo C, Capataz C, Hernandez C, Pallares C, De La Cadena E, Perenguez MN, Correa A, ARIAS CA, Villegas MV. Molecular characterization of carbapenemase-producing Gram negative bacilli from 3 hospitals in Antioquia, Colombia. In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

117. Dipippo AJ, Tverdek FP, Tarrand JJ, Munita JM, ARIAS, CA, Shelburne S, Tran TT, Aitken SL. Previous daptomycin exposure predicts daptomycin non-susceptible Enterococcus faecium bloodstream infections in adult leukemia patients. . In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

118. Valderrama Beltran SL, Gualtero S, Rodriguez J, Osorio J, Alvarez CA, Gil F, Gomez Quintero C, Caro MA, Mackenzie S, Arias G, ARIAS, CA. Risk factors associated with methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infection (CSSTIs) in Colombia. In Abstracts of IDWeek2016. Infectious Disease Society of America. New Orleans, LA (2016).

119. Appel T, Rincon S, Reyes J, Diaz L, Panesso D, ARIAS, CA. In Silico and Transcriptional Analyses of liaXYZ, a Novel Gene Cluster Associated with Daptomycin Resistance in Enterococcus faecium. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2016).

120. Contreras GA, Munita JM, Sahasrabhojane P, Petitto, GS, AudreyW, Aitken S, Shelburne S, ARIAS, CA. Enterococcal Bacteremia in Cancer and Non-Cancer Populations: One Disease, Two Tales. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

121. Davlieva M, Tovar-Yanez A, DeBruler K, Leonard PG, Zianni MR, ARIAS, CA, and Shamoo Y. Adaptive Mutations in Enterococcus faecium LiaR Confer Increased Resistance to Daptomycin through Alteration in LiaFSR Signaling. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

122. A. Khan, D. Panesso, T. Tran, S. Siegel, S. Rincon, M. Davlieva, K.V. Singh, H. Ton-That, Y. Shamoo, ARIAS, CA. LiaX is a Novel Protein that Mediates Daptomycin Resistance and the “See-Saw” Effect in Enterococcus faecalis. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

123. Miller WR, Singh KV, ARIAS, CA, and Murray BE. Cefazolin plus Clavulanic Acid Overcomes the Inoculum Effect in a Methicillin-Susceptible Staphylococcus aureus (MSSA) Rat Endocarditis Mode. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

124. Miller WR, Tran T, Diaz L, Rios R, Reyes J, Shamoo Y, Panesso D and ARIAS, CA.

LiaR-Independent Pathways to Daptomycin and Cephalosporin Resistance Involve


36

Changes in the YxdJK System in Enterococci. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

125. Panesso D, Tran TT, Rincon S, Singh KV, Mileykovskaya E, Dowhan W, Shamoo Y,

ARIAS, CA. Characterization of liaYZ Encoding Transmembrane Proteins Required for Cell Membrane Anionic Phospholipid Redistribution and Antibiotic Resistance in Enterococcus faecalis. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

126. Prater AG, Beabout K, Mehta H, ARIAS, CA, Shamoo Y. Understanding the Role of

Alternative Daptomycin Resistance Mechanisms in Enterococcus faecium. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

127. Rada AM, Orozco N, Agudelo C, Capataz C, De la Cadena E, Perenguez M, Hernandez-Gomez C, Pallares C, Porras P, Ardila J, Ríos R, Reyes J, Díaz L, Correa A, Villegas MV, ARIAS, CA, Restrepo E. Characterization of Carbapenemase-producing Gram-negative Bacilli Clinical Isolates In Antioquia, Colombia Using Whole Genome Sequencing (WGS). In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

128. Rincon S, Cruz MR, Panesso D, Reyes J, Miller W, Garsin DA, ARIAS, CA. In Vivo Evaluation of Daptomycin and The Effect of a liaR Deletion in Enterococcus faecalis using a Caenorhabditis elegans Model. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

129. Rincon S, Singh KV, Panesso D, Miller W, Reyes J, ARIAS, CA. Deletion of liaR Restores Daptomycin (DAP) Efficacy In Vivo Against DAP-Resistant Enterococcus faecium. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

130. Tran TT, Panesso D, Singh KV, Shamoo Y, ARIAS, CA. Mutagenesis of liaX Encoding A Novel Extracellular Protein Associated with Daptomycin Resistance and Cell Membrane Remodeling in Enterococcus faecalis. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

131. Wang X, Davlieva M, Reyes J, Panesso D, ARIAS, CA and Shamoo Y. A Novel

Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci. In Abstracts of Antibiotic Resistance Symposium: Novel Frontiers in Antimicrobial Research. CARMiG. Houston, TX (2017).

132. Ortega-Paredes D, Diaz L, Reyes J, Barba P, Vinueza P, Porras JA, ARIAS, CA, Zurita J. E.coli-producing ESBL harbouring mcr-1 from Ecuador. In Abstracts of the 27th ECCMID, the European Congress of Clinical Microbiology and Infectious Diseases. Vienna, Austria (2017).

133. Berrio, M, Diaz, L, Reyes, J, Ardila, J, Carvajal, LP, Porras, P, Rincon, S, Rios, R, Munita, J, ARIAS, CA. Can Whole Genome Sequencing Identify Heterogeneous Vancomycin Intermediate Staphylococcus aureus (hVISA) Isolates?. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

134. Panesso, D, Rincon, S, Tran, T, Singh, K, Miller, W, Mileykovskaya, E, Dowhan, W, Shamoo, Y, ARIAS, CA. Characterization of lia YZ Encoding Transmembrane Proteins (TM) required for Cell Membrane (CM) Anionic Phospholipid (A-PL) Redistribution and Antibiotic Resistance in Enterococcus faecalis (Efs). In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

135. Nannini, EC, Reyes, J, Diaz, L, Ferro, L, Carvajal, P, Porras, P, Rios, R, Miller W, Munita, J, ARIAS, CA. Clinical and Molecular Characterization of Methicillin-Susceptible Staphylococcus aureus from Patients who Failed Cephalosporin Therapy. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).


37

136. Ortega-Paredes, D, Diaz, L, Reyes, J, Barba, P, Porras, P, Ardilla, J, ARIAS, CA, Zurita, J. Colistin-Resistant Klebsiella pneumoniae in Ecuador. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

137. Jahanbakhsh, S, Singh, B, Yim, J, Smith JR, Tran, T, ARIAS, CA, Rybak, M. Evaluation of Daptomycin Alone and Combined with Beta Lactams or Rifampin against Vancomycin-Resistant Enterococci (VRE) in an In Vitro Biolfilm Model. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

138. Rios, R, Diaz, L, Reyes, J, Planet, P, Narechania, A, Carvajal, L, Munita, J, Porras, P, Cardona, N, Echeverri, A, Rincon, S, Panesso, D, Weinstock, g, ARIAS, CA. Genomic Characterization of Vancomycin-Resistant Enterococcus faecium from Latin America. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

139. Singh, K, Cruz, M, Panesso, D, Miller, W, Reyes, J, Garsin, D, ARIAS, CA. In Vivo Evaluation of Daptomycin (DAP) and the Effect of a liar Deletion in Enterococcus faecalis (Efs) and Enterococcus faecium (Efm) Using Caenorhabditis elegans and Mouse Peritonitis Models. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

140. Miller, W, Tran, T, Diaz, L, Rios, R, Reyes, J, Shamoo, Y, Panesso, D, ARIAS, CA. LiaR-Independent Pathways to Daptomycin and Cephalosporin Resistance Involve Changes in the YxdJK System in Enteroccocci. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

141. van Duin, D, ARIAS, CA, Weston, G, Ostrowsky, B, Cober, E, Richter, S, Doi, Y, Garcia-Diaz, J, Jacob, J, Humphries, R, Kaye, K, Satlin, M, Fries, B, Salata, R, Anderson, D, Kalayjian, R, Hank J, Desai, S, Huskins, W, Wortmann, G, Farrel, J, Wong, D, Komarow, L, Earley, M, Evans, S, Bonomo, R. National Variability in Patients with Carbapenem-Resistant Enterobacteriacae in the US: First Results from CRACKLE-2. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

142. Tran, T, Panesso, D, Siegel, S, Rincon, S, Singh K, Ton-That, H, Shamoo, Y, ARIAS, CA. LiaX is a Novel Protein that Mediates Daptomycin Resistance (DAP-R) in Enterococcus faecalis Through Cell Membrane (CM) Remodeling. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

143. Carvajal, L, Hidalgo, M, Diaz, L, Duarte, C, Reyes, J, Echeverri, A, Rios, R, Ferro, C, Porras, P, Munita, J, ARIAS, CA. OptrA-Mediated Linezolid Resistance (LNZ-R) in Clinical Enterococcus faecalis Isolate from Colombia. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

144. Kebriaei, R, Rice, S, Stamper, K, Tran, T, ARIAS, CA, Rybak, M. Pharmacokinetic, Pharmacodynamic Evaluation of Ampicillin or Ertapenem in Combination with Daptomycin against Vancomycin-Resistant Enterococcus faecium. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

145. Mishra, N, Seepersaud, R, Tran, T, Shelburne, S, Miro, J, Rybak, M, ARIAS, CA, Sullam, p, Bayer, A. Phenotypic and Genotypic Characteristics of In Vitro-Selected High-Level Daptomycin-Resistant (DAP-R) Strains of Clinically-derivd Streptococcus mitis-oralis. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

146. Shamoo, Y, Prater, A, Beabout, K, Davliera, M, ARIAS, CA. Predicting Antibiotic Resistance: Moving from Reaction to Preemption of Pathogens. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

147. Saavedra, S, Diaz, L, Wiesner, M, Correa, A, Arevalo, S, Reyes, J, Hidalgo, A, De la Cadenaa, E, Perenguez, m, Montaño, L, Ardila, J, Rios, R, Porras, p, Villegas, M, ARIAS, CA. Whole Genome Characterization of Clinical Isolates of Enterobacteriaceae Harboring


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mcr-1 in Colombia, 2002 to 2016. In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

148. Khan, A, Tran, T, Panesso, D, Siegel, S, Rincon, S, Singh, KV, Ton-That, H, Shamoo, Y, ARIAS, CA. LiaX is a Novel Protein that Mediates Daptomycin Resistance (DAP-R) and Cell Membrane (CM) Remodeling in Enterococcus faecalis (Efs). In Abstracts of ASMMicrobe 2017. American Society for Microbiology. New Orleans, LA (2017).

149. Van Duin D, Humphries R, Jacob JT, Cober E, Richter SS, Doi Y, Kaye KS, Dhar S, ARIAS CA, Kim A, Garcia-Diaz J, Han JH, Satlin M, Desai S, Weston G, Ostrowsky B, Fries B, Salata R, Wong D, Wortmann G, Kalayjian R, Huskins WC, Anderson DJ, Eilertson B, Komarow L, Earley M, Evans SR, Marshall SH, Rudin SD, Domitrovic TN, Hujer A, Hujer KM, Bonomo RA, Antibacterial Resistance Leadership Group (ARLG). Ceftazidime/avibactam susceptibility patterns in carbapenem-resistant Enterobacteriaceae in the USA: Results from the Consortium on Resistance against Carbapenems in Klebsiella and Other Enterobaceriaceae (CRACKLE-2). In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

150. Contreras G, Diaz L, Rios R, Reyes KC, Kamboj M, Lewis J, Rincon S, Reyes J, Carvajal LP, Panesso D, Sifri CD, Zervos M, Pamer E, Tran TT, Shelburne S, Munita J, ARIAS, CA. A whole genome sequencing (WGS) approach to predict daptomycin susceptibility of Enterococcus faecium. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

151. Rada AM, De La Cadena E, Orozco N, Agudelo Restrepo C, Capataz C, Perenguez MN, Hernandez-Gomez C, Pallares C, Porra P, Ardila J, Rios R, Reyes J, Diaz L, Correa A, Villegas MV, ARIAS, CA, Restrepo E. Plasmid promiscuity explains high endemicity of KPC-2 among Colombian Enterobacteriaceae. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

152. Reyes J, Martinez E, Carvajal LP, Echeverri A, Hernandez-Gomez C, Diaz L, Ardila J, Rios R, Aragon D, Martinez D, De La Cadena E, Ferro C, Gonzalez C, Villegas MV, ARIAS, CA. Emergence of daptomycin resistance in community-associated MRSA USA300 Latin American Variant (USA300-LV). In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

153. Tran TT, Diaz L, Abodakpi H, Ardila J, De La Cadena E, Rios R, Miller W, Riva L, Dinh A, Porras P, Panesso D, Tam V, Munita JM, ARIAS, CA. Cetolozane-tazobactam resistance in multidrug-resistant Pseudomonas aeruginosa isolates not associated with AmpC activity. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

154. Munita JM, Contreras G, Sahasrabhojane P, Sanchez Petitto G, Araos R, Wanger A, Aitken SL, Shelburne SA, ARIAS, CA. A prospective study of enterococcal bacteremia in cancer vs non-cancer populations: one disease, two tales. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

155. Khan A, Davlieva M, Panesso D, Rincon S, Tran T, Wang X, Singh K, Miller W, Shamoo Y, ARIAS, CA. A novel mechanism of resistance against antimicrobial peptides involves extracellular sensing coupled with membrane remodeling mediated by a single protein. In Abstracts of IDWeek2017. Infectious Disease Society of America. San Diego, CA (2017).

156. Panesso D, Latorre M, Rincon S, Miller W, Diaz L, Reyes J, Rios R, Ardila J, Carvajal LP, ARIAS, CA. The LiaR-regulon of daptomycin-resistant Enterococcus faecium. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

157. Miller W, Rios R, Diaz L, Panesso D, Chang M, Sun Z, Palzkill T, ARIAS, CA. Co-occurrence of NDM-5, OXA-181 and CMY-2 in a clinical E. coli isolate from a patient in the United States. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).


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158. Tran TT, Diaz L, Rios R, Dinh A, Jahanbakhsh S, Kebriaei R, Rybak MJ, ARIAS, CA. Genomic pathways associated with daptomycin resistance in daptomycin-susceptible Enterococcus faecium harboring substitution in LiaFSR. In Abstracts of IDWeek2017. Infectious Disease Society of America. San Diego, CA (2017).

159. Miller W, Singh K, ARIAS, CA, Murray B. Cefazolin plus clavulanic acid overcomes the inoculum effect in a methicillin-susceptible Staphylococcus aureus (MSSA) rat endocarditis model. In Abstracts of IDWeek2017. Infectious Diseases Society of America. San Diego, CA (2017).

160. S. Rincon, WR. Miller, D. Panesso, T. Tran, J. Reyes, ARIAS, CA. A liaR deletion in Enterococcus faecalis OG1RF results in increased intracellular killing by human neutrophils. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

161. Panesso D, Singh KV, Rincon S, Reyes J, Miller, W, Tran, TT, ARIAS, CA. Deletion of liaR in Enterococcus faecalis (Efs) restores the Activity of Daptomycin (DAP) in an in vivo Model. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

162. Carvajal LP, Echeverri AM, Díaz L, ARIAS, CA, Rios R, and Reyes J. Determination Of Cefazolin High Inoculum Effect (InE) In Methicillin-Susceptible Staphylococcus aureus (MSSA) Using Nitrocefin Rapid Test. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

163. Davlieva M, Wu C, Prabhakar RG, ARIAS, CA, Shamoo Y. Insight Into Phosphoryl Transfer in LiaFSR Signal Transduction. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

164. Khan, A, Tran, T, Rios, R, Diaz, L, Hanson. B, Dinh, A, Nobakht, C, Wanger, A, Ostrosky-Zeichner, L, ARIAS, CA, Miller, WR.

Double Trouble: Emergence of a high-risk

ST309 Pseudomonas aeruginosa expressing GES-19 and 26 with Resistance to Carbapenems, Ceftazidme/Avibactam and Ceftolozane/Tazobactam. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

165. Nguyen, A, Chen, Y, Mileykovskaya, E, Tran, T, ARIAS, CA.

The Role of Cardiolipin

Synthase in Daptomycin Resistance in Enterococcus faecalis OG1RF. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houton, Texas (2018).

166. Ardila J, Díaz L, Tran TT, Rivas L, Spencer MA, Jain R, Rios R, De la Cadena E, Rakita R, ARIAS, CA, Munita, J.

. Detection of Novel Mutations Associated with Resistance to

Ceftolozane/Tazobactam (TOL/TAZ) in Pseudomonas aeruginosa Clinical Isolates.In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houston, Texas (2018).

167. Tran TT, Mishra NN, Rios R, Diaz L, Ardila J, Porras P, Seepersaud R, Sullam PM, Bayer AS, ARIAS, CA.

Daptomycin Resistance in Viridans Streptococci is Associated with

Changes in Cell Membrane Phospholipid Enzymes. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houston, Texas (2018).

168. Zhou Y, Davlieva M, Prater AG, ARIAS, CA, Shamoo Y. Understanding the Structure

and Function of MurAA and its Potential Relationship to Daptomycin Resistance in Enterococcus faecium. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houston, Texas (2018).

169. Reyes J, Carvajal LP, Rios R, Echeverri AM, ARIAS, CA, Seas C, Rincon S, Panesso D, Diaz L, and Latin America Working Group on Bacterial Resistance. Healthcare-Associated Methicillin-Resistant Staphylococcus aureus (HA-MRSA) Characterization in Latin-America. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houston, Texas (2018).


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170. Prater AG, Beabout K, Mehta H, ARIAS, CA, Shamoo Y. Understanding the Role of

Alternative Daptomycin Resistance Mechanisms in Enterococcus faecium. In Abstracts of the 1st Annual Antibiotic Resistance and Stewardship Conference. Houston, Texas (2018).

171. Nguyen A, Chen Y Mileykovskaya E, Tran TT, ARIAS, CA. The Role of Cardiolipin Synthase in Daptomycin Resistance in Enterococcus faecalis OG1RF. In Abstracts of the ASM Microbe 2018 Meeting. Atlanta, Georgia (2018).

172. Khan A, Tran TT, Rios R, Diaz L, Dinh A, Nobakht C, Wanger A, Ostrosky-Zeichner L, ARIAS, CA, Miller R William. Emergence of a high-risk ST309 Pseudomonas aeruginosa harboring GES-19 and 26 conferring resistance to carbapenems, ceftazidme/avibactam (CZA) and ceftolozane/tazobactam (C/T): A New Threat in the USA. In Abstracts of the ASM Microbe 2018 Meeting. Atlanta, Georgia (2018).

173. Kebriaei1 R, Rice S, Stamper K, Tran TT, ARIAS, CA, Rybak M, Wayne State Univ., Detroit, MI, Univ. of Texas McGovern Sch. of Med., Houston, TX. Daptomycin-Ampicillin Combination Therapy: A Unique Approach against Daptomycin Resistant Enterococcus faecium. In Abstracts of the ASM Microbe 2018 Meeting. Atlanta, Georgia (2018).

174. Rincon S, Panesso D, Singh K, Miller WR, Reyes J, Tran TT, ARIAS, CA. LiaR Deletions in Enterococci Restore Daptomycin (Dap) Efficacy In Vivo and Increase Intracellular Killing by Human Polymorphonuclear Leukocytes (PMNs). In Abstracts of the ASM Microbe 2018 Meeting. Atlanta, Georgia (2018).

175. Avery LM, Kuti JL, Weisser M, Egli A, Rybak MJ, Zasowski E, ARIAS, CA, Contreras GA, Chong PP, Aitken SL, DiPippo AJ, Wang JT, Britt NS, Nicolau DP. Daptomycin (Dap) Pharmacodynamics (Pd) in Patients with Enterococcal Bloodstream Infections (BSIs). In Abstracts of the ASM Microbe 2018 Meeting. Atlanta, Georgia (2018).

B. PEER REVIEWED (*First or corresponding author)

1. Quintero, GA., ARIAS, CA., Cuervo, J. Liver Metastases. Cirugía Iberoamericana (Madrid) 3:65- 68 (1994).

2. *ARIAS, CA., Broughton, K., Hall, LMC. Sequence heterogeneity in the capsule production locus of Streptococcus pneumoniae. Advances in Experimental Medicine and Biology 418:761-763 (1997).

3. *ARIAS, CA., Martin-Martinez, M., Blundell, T., Arthur, M., Courvalin, P., and Reynolds, P.E. Characterization and modelling of VanT: a novel membrane bound serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174. Molecular Microbiology 31:1653-1664 (1999).

4. Reynolds, P.E, ARIAS, CA., Courvalin, P. Gene vanXYC encodes a D,D-dipeptidase (VanX) and a D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum. Molecular Microbiology 34:341-349 (1999).

5. *ARIAS, CA., Courvalin, P., and Reynolds P.E. The vanC gene cluster of vancomycin-resistant Enterococcus gallinarum BM4174. Antimicrobial Agents and Chemotherapy 44:1660-1666 (2000).

6. Lawrence, ER., ARIAS, CA., Duke, B., Beste, D., Broughton, K., Efstratiou, A., George, RC, Hall LMC. Evaluation of serotype prediction by cpsA-cpsB gene polymorphism in Streptococcus pneumoniae. Journal of Clinical Microbiology 38:1319-1327(2000).

7. *ARIAS, CA., Weisner, J., Blackburn, J., Reynolds, PE. Serine and alanine racemase activities of VanT: A protein necessary for vancomycin resistance in Enterococcus gallinarum. Microbiology 146:1727-1734 (2000).


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8. *Ambur, H., Reynolds, PE., ARIAS, CA. Characterization of a D:Ala-D-Ala ligase gene flanking the vanC cluster: Evidence for three ligase genes in in vancomycin-resistant Enterococcus gallinarum. Antimicrobial Agents and Chemotherapy 46:95-100 (2002).

9. *Panesso, D., Ospina, S., Robledo, J., Peña, J., and ARIAS, CA. First characterization of a cluster of VanA-type vancomycin-resistant Enterococcus faecium in a Colombian hospital. Emerging Infectious Diseases 8:961-965 (2002).

10. *ARIAS, CA., Reyes, J., Zuñiga, M., Cortes, L. Cruz, C., Rico, C.L., and Panesso D. A multicentric surveillance of antimicrobial resistance in enterococci and staphylococci from Colombian hospitals, 2001-2002. Journal of Antimicrobial Chemotherapy 51:59-68 (2003).

11. *ARIAS, CA., Peña, J.P, Panesso, D., and Reynolds, P.E. Role of the transmembrane domain of VanT in resistance to vancomycin in Enterococcus gallinarum. Journal of Antimicrobial Chemotherapy 51:557-564 (2003).

12. *ARIAS, CA., Quintero, G., Vanegas, R.N., Rico, C.L. and Patiño, J.F. Surveillance of surgical site Infections: Decade of experience at a Colombian tertiary care center. World Journal of Surgery 27:529-533 (2003).

13. *Gomez, JM., Fajardo, R., Patiño, JF., ARIAS, CA. Necrotizing fasciitis due to Vibrio alginolyticus in an immunocompetent patient. Journal of Clinical Microbiology 41:3427-29 (2003).

14. *Hidalgo, M., Castañeda, E., ARIAS, CA. Tolerance to vancomycin in a multi-resistant, Colombian isolate of Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy 52:300-302 (2003).

15. *Panesso, D., Abadía, L., Reynolds, P., Vanegas, N., Courvalin, P., ARIAS, CA. Transcriptional analysis of the vanC cluster from constitutive and inducible strains of vancomycin-resistant Enterococcus gallinarum. Antimicrobial Agents and Chemotherapy. 49:1060-1066 (2005).

16. *Cruz, C., Moreno, J., Renzoni, A., Hidalgo, M., Reyes, J.,Shrenzel, J., Lew, D., Castañeda, E., ARIAS, CA. Tracking methicillin-resistant Staphylococcus aureus clones in Colombian hospitals during seven years (1996-2003): emergence of new dominant clone. International Journal of Antimicrobial Agents. 26:457-462 (2005).

17. *ARIAS, CA., Robredo, B., Singh, KV., Torres, CA., Panesso, D., Murray, BE. Rapid identification of Enterococcus hirae and Enterococcus durans by PCR and detection of a homolog of the E. hirae muramidase-2 gene in E. durans. Journal of Clinical Microbiology. 44:1567-1570 (2006).

18. *Alvarez, CA. Barrientes, O., Leal, AL., Contreras, GA., Barrero, L., Rincón, S., Diaz,L., Vanegas, N., ARIAS, CA. Community-associated methicillin-resistant Staphylococcus aureus, Colombia. Emerging Infectious Diseases. 12:2000-01 (2006).

19. *ARIAS, CA., Cortes, L., Murray, BE. Chaining in enterococci revisited: Correlation between chain length and gelatinase (GelE) phenotype, gelE or fsrB genes among clinical isolates of Enterococcus faecalis. Journal of Medical Microbiology 56:286-8 (2007).

20. *Reyes, J., Hidalgo, M., Díaz, L., Bohorquez, M., Rincon, S., Moreno J., Vanegas, N., Castañeda, E., ARIAS, CA. Characterization of macrolide resistance from Colombian hospitals: A country-wide surveillance. International Journal of Infectious Diseases 11:329-36 (2007).

21. *ARIAS, CA., Singh, KV., Panesso, D., Murray, BE. Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis including β-lactamase producing and vancomycin-resistant isolates. Antimicrobial Agents and Chemotherapy 51:2043-47(2007).

22. Toh, SM., Xiong, L., ARIAS, CA., Villegas, MV., Lolans, K., Quinn, JP., Mankin, SA. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Molecular Microbiology 64:1506-14 (2007).


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23. *ARIAS, CA., Singh, KV., Panesso, D., Murray, BE. Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model. Journal of Antimicrobial Chemotherapy 60:594-8 (2007).

24. *ARIAS, CA., Torres, H., Singh, KV., Panesso, D., Murray, BE. Failure of daptomycin in the treatment of endocarditis caused by a heterogeneously vancomycin-resistant strain of Enterococcus faecium with in vivo loss of the vanA gene cluster. Clinical Infectious Diseases 45:1343-6 (2007).

25. *ARIAS, CA., Vallejo, M., Reyes J., Panesso, D., Moreno, J., Castañeda, E., Villegas, MV., Murray, BE., Quinn, JP. Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase. Journal of Clinical Microbiology 46:892-6 (2008).

26. *Hidalgo, M., Reyes, J., Cárdenas, AM., Díaz, L., Rincón, S., Vanegas, N, Díaz, PL., Castañeda, E., ARIAS, CA. Resistance profiles to fluoroquinolones in clinical isolates of Gram-positive cocci from Colombian hospitals, 1994-2004. Biomedica 28:284-94 (2008).

27. Bourgogne., A, Garsin, D., Qin, X., Singh, KV., Sillanpaa, J., Yerrapragada, S., Ding, Y., Dugan-Rocha, S., Buhay, C., Shen, H., Chen, G., Williams, G., Muzny, D., Maadani, A., Fox, KA., Gioia, J., Chen, L., Shang, Y., ARIAS, CA., Nallapareddy, SR., Zhao, M., Prakash, V., Chowdhury, S., Jiang, H., Gibbs, RA., Murray, BE., Highlander, SK., Weinstock, GM. Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF. Genome Biology 9:R110 (2008).

28. *Contreras GA., DiazGranados, CA., Cortes, L., Reyes, J., Vanegas, S., Panesso, D., Rincón, S., Díaz, L., Prada, G., Murray, BE., and ARIAS, CA. Nosocomial Outbreak of vancomycin-resistant Enteroccocus gallinarum: Untaming of rare species of enterococci. Journal of Hospital Infection 70:346-52 (2008).

29. *ARIAS, CA., Rincón, S., Chowdhury, S., Martínez, E., Coronell, W., Reyes, J., Nallapareddy, SR., Murray, BE. Methicillin-Resistant Staphylococcus aureus USA300 clone and VREF: A US-Colombian Connection? New England Journal of Medicine 359:2177-9 (2008).

30. Chowdhury, S., ARIAS, CA., Nallapareddy, SR., Reyes, J., Willems, RJ., Murray,BE. Novel tri-locus sequence typing discriminates evolutionary relationships in Enterococcus faecalis. Journal of Clinical Microbiology. 47:2713-19 (2009).

31. *ARIAS, CA., Panesso, D., Singh, KV., Rice, LB., Murray, BE. Co-transfer of antibiotic resistant genes and a hylEfm-containing plasmid in Enterococcus faecium. Antimicirobial Agents and Chemotherapy 53:4240-6 (2009).

32. *Galloway-Peña, JR., Nallapareddy, SR., ARIAS, CA., Eliopoulos, GM., Murray, BE. Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium. Journal of Infectious Diseases 200:1566-73 (2009).

33. *Reyes, J., Rincón, S., Díaz, L., Panesso, D., Contreras, GA., Zurita, J., Carrillo, C., Merentes, A., Guzmán, M., Adachi, J., Chowdhury, S., Murray, BE and ARIAS, CA. Dissemination of methicillin-resistant Staphylococcus aureus (MRSA), USA300, sequence type 8 lineage in Latin-America. Clinical Infectious Diseases 49:1861-7 (2009).

34. *Campo, M., Phung, MK., Ahmed, R., Cantey, P., Bishop, H., Bell, TK., Gardiner, C., and ARIAS, CA. A woman with HIV, brain abscesses and eosinophilia. Clinical Infectious Diseases 50:239-40 (2010).

35. Kim, DS., Singh, KV., Nallapareddy, SR., Xiang, Q., Panesso, D., ARIAS, CA., Murray, BE. The fms21 (pilA)-fms20 locus encoding one of four pili of Enterococcus faecium is harbored on a large transferable plasmid associated with gut virulence and colonization. Journal of Medical Microbiology 59:505-7 (2010).

36. *Panesso, D., Reyes, J., Rincon, SR., Diaz, L., Galloway-Peña, JR., Zurita, J., Carrillo, C., Merentes, A., Guzman, M., Adachi, J., Murray, BE., ARIAS, CA. Molecular epidemiology of


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vancomycin-resistant Enterococcus faecium: A prospective, multicenter study in South-American hospitals. Journal of Clinical Microbiology 48:1562-69 (2010).

37. *Panesso, D., Montealegre, MC., Rincon, SR., Mojica, MF., Rice, LB., Singh, KV., Murray, BE., ARIAS, CA. The hylEfm gene in pHylEfm of Enterococus faecium is not required in pathogenesis of murine peritonitis. BMC Microbiology 11:20 (2011).

38. Shen, Qi., Feng, W., Long, MS., Duan, X., Jaijakul, S., ARIAS, CA., Brown, RE., Zhao, Multicentric hepatic Epstein-Barr virus- associated smooth muscle tumors in an adult acquired immunodeficiency syndrome patient: a case report and review of the literature. International Journal of Clinical and Experimental Pathology 4:421-429 (2011).

39. *ARIAS, CA., Panesso, D., McGrath, D., Qin, X., Mojica, MF., Miller, C., Diaz, L., Tran, TT., Rincon, S., Barbu, EM., Reyes, J., Lobos, E., Sodergren, E., Pasqualini, R., Arap. W., Quinn, JP., Shamoo, Y., Murray, BE., Weinstock, GM. Genetic basis for in vivo resistance to daptomycin in enterococci. New England Journal of Medicine 365:892-900 (2011).

40. Hall, AD., Steed, ME., ARIAS, CA., Murray, BE., Rybak, MJ. Evaluation of standard and high-dose daptomycin versus linezolid against vancomycin-resistant enterococci in a simulated endocardial vegetation in vitro model. Antimicrobial Agents and Chemotherapy 56:3174-3180 (2012).

41. *Tran, TT., Jaijakul, S., Lewis, CT., Diaz, L., Panesso, D., Kaplan, HB., Murray, BE., Wanger, A., ARIAS, CA. Native valve endocarditis caused by heterogenous high-level daptomycin-resistant Corynebacterium striatum: “collateral damage” from daptomycin therapy? Antimicrobial Agents and Chemotherapy 56:3461-3464 (2012).

42. *Diaz, SL., Kiratisin, P., Mendes, R., Panesso, D., Singh, KV., ARIAS, CA. Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis. Antimicrobial Agents and Chemotherapy 56:3917-22 (2012).

43. *Munita, JM., Panesso, D., Diaz, L., Truc, TT., Reyes, J., Wanger, A. Murray, BE., ARIAS, CA. Correlation between mutations in liaFSR of Enterococcus faecium and minimal inhibitory concentration of daptomycin: revisiting daptomycin breakpoints. Antimicrobial Agents and Chemotherapy 56:4354-4359 (2012).

44. *Mishra, NN., Bayer, AS., Tran, TT., Shamoo, Y., Mileykovskaya, E., Dowhan, W., Guan, Z., ARIAS, CA. Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. PLoS One 7:e43958 (2012).

45. *Gordon, R., Sutton, DE., Thompson, EH., Shrikanth, V.,Verkley, GJM., Stielow, B., Mays, R, Oleske, D., Morrison, LK., Lapolla, WJ., Galfione, S., Tyring, S., Samathanam, CA., Fu, J., Wickes, BL., Mulanovich, V., Wanger, A., ARIAS, CA. Cutaneous phaeohyphomycosis caused by Paraconiothyrium cyclothyrioides. Journal of Clinical Microbiology 50:3795-8 (2012).

46. Jaijakul, S., ARIAS, CA., Hossein, M., Arduino, C., Wootton, S., Hasbun, R. Toscana meningoencephalitis: A comparison to other central nervous system infections. Journal of Clinical Virology 55:204-8 (2012).

47. Hall, AD., Steed, ME., ARIAS, CA., Murray, BE. Rybak, MJ. Evaluation of standard and high-dose daptomycin versus linezolid against vancomycin-resistant enterococci in a simulated endocardial vegetation in vitro model. Antimicrobial Agents and Chemotherapy 56:3174-3180 (2012).

48. *Tran, TT., Panesso, D., Gao, H., Roh, J., Munita, JM., Reyes, J., Diaz, L., Lobos, EA., Shamoo, Y., Mishra, NN., Bayer, AS., Murray, BE., Weinstock, GM., ARIAS, CA. Whole-genome analysis of a daptomycin-susceptible Enterococcus faecium and its daptomycin resistant variant arising during therapy. Antimicrobial Agents and Chemotherapy 57:261-8 (2013).

49. Davlieva, M., Zhang, W., ARIAS, CA., Shamoo Y. Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci. Antimicrobial Agents and Chemotherapy 57:289-96 (2013).


44

50. Ben-Amia, R., Watson, CC., Lewis, RE., Albert, N., ARIAS, CA., Raad, II., Kontoyiannis, DP. Drosophila melanogaster as a model to explore the effects of methicillin-resistant Staphylococcus aureus strain type on virulence and response to linezolid treatment. Microbial Pathogenesis 55:16-20 (2013).

51. *Munita, JM., Tran, TT., Diaz, L., Panesso, D., Reyes, J., Murray, BE and ARIAS, CA. A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant Enterococcus faecalis. Antimicrobial Agents and Chemotherapy 57:2831-2833 (2013).

52. *Diaz, L., Kontoyiannis, DP., Panesso, D., Albert, N., Singh, KV., Tran, TT., Munita, JM., Murray, BE., ARIAS, CA. Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus. Journal of Infectious Diseases 208:83-91 (2013).

53. *Rincón, S., Reyes, J., Carvajal, LP., Rojas, N., Cortés, F., Panesso, D., Guzmán, M., Zurita J., Adachi, JA., Murray, BE., Nannini, EC., ARIAS, CA. Cefazolin high-inoculum effect in methicillin-susceptible Staphylococcus aureus from South American hospitals. Journal of Antimicrobial Chemotherapy 68:2773-2778 (2013).

54. *Tran, TT., Panesso, D., Mishra, NN., Mileykovskaya, E., Guan, Z., Munita, JM., Reyes, J., Diaz, L., Weinstock, GM., Murray, BE., Shamoo, Y., Dowhan, W., Bayer, AS., ARIAS, CA. Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids Mbio 4:4 e00281 (2013).

55. Nannini, E., ARIAS, CA. Occult Staphylococcus aureus bacteremia: other points to consider. Clinical Infectious Diseases 56:1679 (2013).

56. Altshuler, J., Aitken, SL., Guervil, D., Esaian, D., Papadopoulos, J., ARIAS, CA. Treatment of extended-spectrum beta-lactamase Enterobacteriaceae with cefepime: the dose matters, too. Clinical Infectious Diseases 57:915-916 (2013).

57. Miller, C., Kong, J., Tran, TT., ARIAS, CA., Saxer, G., Shamoo, Y. Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance. Antimicrobial Agents and Chemotherapy 57:5373-5383. Erratum 58:631(2013).

58. Nannini, EC., Singh, KV., ARIAS, CA., Murray, BE. In vivo effect of cefazolin, daptomycin, and nafcillin in experimental endocarditis with a methicillin-susceptible Staphylococcus aureus strain showing an inoculum effect against cefazolin. Antimicrobial Agents and Chemotherapy 57:4276-4281 (2013).

59. Chowdhury, SA., Nallapareddy, SR., ARIAS, CA., Murray BE. The majority of a collection of US endocarditis Enterococcus faecalis isolates from 1974 to 2004 lack capsular genes and belong to diverse, non-hospital associated lineages. Journal of Clinical Microbiology 52:549-56 (2014).

60. Perez F, ARIAS CA, Bush K, Drusano GL, Lolans K, Munoz-Price LS, Nicolau DP, Queenan AM, Rice LB, Segreti J, Shlaes DM, Weinstein RA, Bonomo RA. In memoriam: John P. Quinn, MD. Clinical Infectious Diseases 58:748-50 (2014).

61. *Rossi, F., Diaz, L., Wollam, A., Panesso, D., Zhou, Y., Rincon, S., Narechania, A., Xing, G., Di Gioia, TSR., Doi, A., Tran, TT., Reyes, J., Munita, JM., Carvajal, LP., Hernandez-Roldan A., Brandao D., van der Heijden, IM., Murray, BE., Planet, PJ., Weinstock, GM., ARIAS, CA. Transferable high-level vancomycin resistance in community-associated MRSA genetic lineage. New England Journal of Medicine 370:1524-31 (2014).

62. *Diaz, L., Tran, TT., Munita, JM., Miller, WR., Rincon, S., Carvajal, LP., Wollam, A., Reyes, J., Panesso, D., Rojas, NL., Shamoo, Y., Murray, BE., Weinstock, GM., ARIAS, CA. Whole-genome analyses of Enterococcus faecium isolates with diverse daptomycin MICs. Antimicrobial Agents and Chemotherapy 58:4527-4534 (2014).

63. Werth, BJ., Steed, ME., Ireland, CE., Tran, TT., Nonejuie, P., Murray, BE., Rose, WE., Sakoulas, G., Pogliano, J., ARIAS, CA., Rybak MJ. Defining daptomycin resistance prevention exposures in vancomycin-resistant Enterococcus (VRE) faecium and E. faecalis. Antimicrob Agents and Chemotherapy. 58:5253-61 (2014).


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64. *Munita, JM., Mishra, NN., Alvarez, D., Tran, TT., Diaz, L., Panesso, D., Reyes, J., Murray, BE., Adachi, JA., Bayer, AS, ARIAS, CA. Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions. Clinical Infectious Diseases. 59:1277-80 (2014).

65. *Reyes, J., Panesso D., Tran TT., Mishra NN., Cruz MR., Munita JM., Singh KV., Yeaman M., Murray BE., Shamoo, Y., Garsin D., Bayer, AS., ARIAS, CA. A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis. Journal of Infectious Diseases 211:1317-1325 (2015)

66. Correa, A., Del Campo, R., Perenguez, M., Blanco, VM., Rodríguez-Baños, M., Maya, JJ., Rojas, L., Cantón, R., ARIAS, CA., Villegas MV. Dissemination of high-risk clones of Pseudomonas aeruginosa in Colombia. Antimicrobial Agents and Chemotherapy 59:2421-5 (2015)

67. Davlieva, M, Shi Y., Leonard PG., Johnson, TA., Zianni, M., ARIAS, CA., Ladbury, JE,M Shamoo, Y. A variable DNA recognition site organization establishes the LiaR mediated cell envelope stress response of enterococci to daptomycin. Nucleic Acids Research 43:4758-73 (2015).

68. *Planet, PJ., Kolokotronis SE., Narechania A., Reyes J., Xing G., Rincon S., Smith H., Panesso D., Ryan Ch., Diaz L., Sebra R., Nolan RL., Tenover FC., Weinstock GM., Robinson DA., ARIAS, CA. Parallel epidemics of community-associated USA300 MRSA in North and South America. Journal of Infectious Diseases 212:1874-82 (2015).

69. *Panesso, D., Planet, PJ., Diaz, L., Hugonnet, JE., Tran, TT., Narechania, A Munita, JM, Rincon, S., Carvajal, LP., Reyes, J., Londono, A., Smith, H., Sebra, R., Deikus, G., Weinstock, GM., Murray, BE., Rossi, F., Arthur, M., ARIAS, CA. Methicillin-susceptible Staphylococcus aureus, Brazil. Emerging Infectious Diseases 10:1844-8 (2015).

70. Beadout, K., Hammerstrom, T., Perez, A., Magalhães, B., Prater, A., Clements, T., ARIAS CA., Saxer, G., Shamoo, Y. The ribosomal S10 protein is a general target for decreased tigecycline susceptibility. Antimicrobial Agents and Chemotherapy 59;9:5661-6 (2015).

71. *Hidalgo, M., Carvajal, LP., Rincon, S., Faccini-Martínez, AA., Tres-Palacios, AA., Mercado, M., Palomá, SL., Rayo, LX., Acevedo, JA., Reyes, J., Panesso, D., Alvarez, C., ARIAS, CA. Methicillin-Resistant Staphylococcus aureus USA300 Latin American variant in patients undergoing hemodialysis and HIV-infected in a hospital in Bogotá, Colombia. PLoS One 10:e0140748 (2015).

72. *Panesso, D., Reyes, J., Gaston, E., Deal, M., Londoño, A., Nigo, M., Munita, JM., Miller, W., Shamoo, Y., Tran, TT., ARIAS, CA. Deletion of liaR reverses daptomycin resistance in Enterococcus faecium independent of the genetic background. Antimicrobial Agents and Chemotherapy 59:7327-34 (2015).

73. García, C., Astocondor, L., Reyes, J., Carvajal, LP., ARIAS, CA., Seas, C. Community-associated infection in a Remote Amazon Basin Area, Peru. Emerging Infectious Diseases 22:921-2 (2016).

74. *Shukla, BS., Shelburne, S., Reyes, K., Kamboj, M., Lewis, JD., Rincon, SL., Reyes, J., Carvajal, LP., Panesso, D., Sifri, CD., Zervos, MJ., Pamer, EG., Tran, TT., Adachi, J., Munita, JM., Hasbun, R., ARIAS, CA. Influence of MIC in clinical outcomes of Enterococcus faecium bacteremia treated with daptomycin: Is It Time to Change the Breakpoint? Clinical Infectious Diseases 62:1514-20 (2016).

75. Harp, JR., Saito, HE., Bourdon, AK., Reyes, J., ARIAS CA,, Campagna SR, Fozo EM. Exogenous Fatty Acids Protect Enterococcus faecalis from Daptomycin-Induced Membrane Stress Independently of the Response Regulator LiaR. Applied and Environmental Microbiology 82:4410-20 (2016).

76. Davlieva M, Tovar-Yanez A, DeBruler K, Leonard PG, Zianni MR, ARIAS CA, Shamoo Y. An Adaptive mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide


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Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State. Journal of Molecular Biology. S0022-2836(16)30395-32016. 428:4503-4519 (2016).

77. *Planet PJ, Diaz L, Rios R, ARIAS CA. Global Spread of the Community-Associated MRSA USA300 Latin American Variant. Journal of Infectious Diseases 214:1609-1610 (2016).

78. *Nigo, M., Diaz, L., Carvajal, LP., Tran, TT., Rios, R., Panesso, D., Garavito, JD., Miller, WR., Wanger, A., Weinstock, GM., Munita, JM., ARIAS CA*. Ceftaroline-Resistant, Daptomycin-Tolerant and hetero-VISA MRSA Causing Infective Endocarditis. Antimicrobial Agents and Chemotherapy 61:e01235-16 (2017).

79. DiPippo AJ, Tverdek FP, Tarrand JJ, Munita JM, Tran TT, ARIAS CA, Shelburne SA, Aitken SL. Daptomycin non-susceptible Enterococcus faecium in leukemia patients: role of prior daptomycin exposure. Journal of Infection 74:243-247 (2017).

80. Mishra NN, Tran TT, Seepersaud R, Garcia-de-la-Maria C, Faull K, Yoon A, Miro JM, Rybak MJ, Bayer AS, ARIAS CA, Sullam PM. Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis oralis by a Novel Mechanism. Antimicrob Agents Chemother 61:e2435-16 (2017).

81. Wang X, Davlieva M, Reyes J, Panesso D, ARIAS CA, Shamoo Y. A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci. Antimicrob Agents Chemother Antimicrob Agents Chemother. 61:e01422-16 (2017).

82. Tran TT, Tam VH, Murray BE, ARIAS CA, Singh KV. Efficacy of telavancin alone and in combination with ampicillin in a rat model of Enterococcus faecalis endocarditis. Antimicrobial Agents and Chemotherapy 61:e02489-16 (2017).

83. Munita JM, Aitken SL, Miller WR, Perez F, Rosa R, Shimose LA, Lichtenberger PN, Abbo LM, Jain R, Nigo M, Wanger A, Araos R, Tran TT, Adachi J, Rakita R, Shelburne S, Bonomo RA, ARIAS CA. Multicenter Evaluation of ceftolozane/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa. Clinical Infectious Diseases 65:158-161 (2017).

84. Shelburne SA, Kim J, Munita JM, Sahasrabhojane P, Shields RK, Press EG, Li X, ARIAS CA, Cantarel B, Jiang Y, Kim MS, Aitken SL, Greenberg DE. Whole genome sequencing accurately Identifies resistance to extended spectrum β-lactams for major Gram-negative bacterial pathogens. Clinical Infectious Diseases 65:738-745 (2017).

85. Yim J, Smith JR, Singh NB, Rice S, Stamper K, Garcia de la Maria C, Bayer AS, Mishra NN, Miró JM, Tran TT, ARIAS CA, Sullam P, Rybak MJ. Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs). Journal of Antimicrobial Chemotherapy 72:2290–2296 (2017)

86. Garcia-de-la-Maria C, Xiong YQ, Pericas JM, Armero Y, Moreno A, Mishra NN, Rybak MJ, Tran TT, ARIAS CA, Sullam PM, Bayer AS, Miro JM. Impact of high-level daptomycin resistance in the Streptococcus mitis Group on virulence and survivability during daptomycin treatment in experimental infective endocarditis. Antimicrobial Agents and Chemotherapy 61:e02418-16 (2017).

87. Singh KV, Tran, TT, Nannini EC, Tam V, ARIAS CA, Murray BE. Efficacy of ceftaroline against methicillin-susceptible Staphylococcus aureus exhibiting the cefazolin high inoculum effect in a rat model of endocarditis. Antimicrobial Agents and Chemotherapy 61:e00324-17 (2017).

88. *ARIAS CA, Reyes J, Carvajal LP, Rincon S, Diaz L, Panesso D, Ibarra G, Rios R, Munita JM, Salles MJ, Alvarez-Moreno C, Labarca J, Garcia C, Luna CM, Mejia-Villatoro C, Zurita J, Guzman-Blanco M, Rodriguez-Noriega E, Narechania A, Rojas LJ, Planet PJ, Weinstock GM, Gotuzzo E, Seas C. A prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacterimia in Nine Latin American Countries. Antimicrobial Agents and Chemotherapy 61:e00816-17 (2017).


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89. *Rojas LJ, Weinstock GM, De La Cadena E, Diaz L, Rios R, Hanson BM, Brown JS, Vats P, Phillips DS, Nguyen H, Hujer KM, Correa A, Adams MD, Perez F, Sodergren E, Narechania A, Planet PJ, Villegas MV, Bonomo RA, ARIAS, CA. An Analysis of the Epidemic of KPC-Producing Klebsiella pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the "Perfect Storm”. Journal of Infectious Diseases 27:82-92 (2017).

90. Saavedra SY, Diaz L, Wiesner M, Correa A, Arévalo SA, Reyes J, Hidalgo AM, de la Cadena E, Perenguez M, Montaño LA, Ardila J, Ríos R, Ovalle MV, Díaz P, Porras P, Villegas MV, ARIAS, CA, Beltrán M, Duarte C. Genomic and Molecular Characterization of Clinical Isolates of Enterobacteriaceae Harboring mcr-1 in Colombia, 2002-2016 Antimicrobial Agents and Chemotherapy 61: e00841-17 (2017).

91. Correa A, Del Campo, R, Escandon-Vargas K, Perenguez M, Rodrıguez-Banos M, Hernandez-Gomez C, Pallares C, Perez F, ARIAS CA, Canton R, Villegas Maria V. Distinct genetic diversity of carbapenem-resistant Acinetobacter baumannii from Colombian hospitals. Microbial Drug Resistance 24(1):48-54 (2018).

92. Seas C, Garcia C, Salles MJ, Labarca J, Luna C, Alvarez-Moreno C, Mejía-Villatoro C, Zurita J, Guzmán-Blanco M, Rodríguez-Noriega E, Reyes J, ARIAS, CA, Carcamo C, Gotuzzo E; Latin American Working Group on Antimicrobial Resistance. Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study. Journal of Antimicrobial Chemotherapy 73:212-222 (2018).

93. Challagundla L, Luo X, Tickler IA, Didelot X, Coleman DC, Shore AC, Coombs GW, Sordelli DO, Brown EL, Skov R, Larsen AR, Reyes J, Robledo IE, Vazquez GJ, Rivera R, Fey PD, Stevenson K, Wang SH, Kreiswirth BN, Mediavilla JR, ARIAS, CA, Planet PJ, Nolan RL, Tenover FC, Goering RV, Robinson DA. Range Expansion and the Origin of USA300 North American Epidemic Methicillin-Resistant Staphylococcus aureus. MBio. 9: e02016-17 (2018).

94. *Nigo M, Luce AM, ARIAS, CA. Long Term Use of Tedizolid as Suppressive Therapy for Recurrent Methicillin-Resistant Staphylococcus aureus Graft Infection. Clinical Infectious Diseases 66:1975-1976 (2018).

95. Beganovic M, Luther MK, Rice LB, ARIAS, CA, Rybak MJ, LaPlante KL. A Review of Combination Antimicrobial Therapy for Enterococcus Faecalis Bloodstream Infections and Infective Endocarditis. Clinical Infectious Diseases. 67:303-309 (2018).

96. Foolad F, Taylor BD, Shelburne SA, ARIAS, CA, Aitken SL. Association of Daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a review. Journal of Antimicrobial Chemotherapy. 73(9):2277-2283 (2018)

97. Li X, ARIAS, CA, Aitken SL, Galloway Peña J, Panesso D, Chang M, Diaz L, Rios R, Numan Y, Ghaoui S, DebRoy S, Bhatti MM, Simmons DE, Raad I, Hachem R, Folan SA, Sahasarabhojane P, Kalia A, Shelburne SA. Clonal Emergence of Invasive Multidrug-Resistant Staphylococcus epidermidis Deconvoluted via a Combination of Whole-Genome Sequencing and Microbiome Analyses. Clinical Infectious Diseases. 67:398-406 (2018).

98. Kebriaei R, Rice SA, Singh KV, Stamper KC, Dinh AQ, Rios R, Diaz L, Murray BE, Munita JM, Tran TT, ARIAS, CA, Rybak MJ. Efficacy of Daptomycin Monotherapy and In Combination with β-lactams for Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions: Influence of The Inoculum Effect. Antimicrobial Agents and Chemotherapy. 62:e00315-18 (2018).

99. Campeau SA, Schuetz AN, Kohner P, ARIAS, CA, Hemarajata P, Dien Bard J, Humphries RM. Variability of daptomycin minimum inhibitory concentrations for Enterococcus faecium when measured by reference broth microdilution and gradient diffusion tests. Antimicrobials Agents and Chemotherapy. 62(9):e00745-18 (2018)

100. *Miller WR, Seas C, Carvajal LP, Diaz L, Echeverri AM, Ferro C, Rios R, Porras P, Luna C, Gotuzzo E, Munita JM, Nannini E, Carcamo C, Reyes J, ARIAS, CA. The Cefazolin


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Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Staphylococcus aureus Bacteremia. Open Forum Infect Dis. 23;5(6):ofy123 (2018).

101. Miller WR, Singh KV, ARIAS CA, Murray BE. Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis. Antimicrobials Agents and Chemotherapy doi: 10.1128/AAC.01158-18 (2018) In press

102. Avery LM, Kuti JL, Weisser M, Egli A, Rybak MJ, Zasowski EJ, ARIAS CA, Contreras GA, Chong PP, Aitken SL, DiPippo AJ, Wang JT, Britt NS, Nicolau DP. Clinical Infectious Diseases. doi: 10.1093/cid/ciy749 (2018). In press

103. *Malek A, Gomez-Villegas SI, de la Hoz A, Nowbakht C, ARIAS CA. A 19-Year Old Man with IgA Vasculitis After Vaccination. Brazilian Journal of Infectious Diseases. In press (2018)

REVIEWS AND EDITORIALS (*corresponding author) 1. *ARIAS, CA. Molecular mechanisms of resistance to glycopeptides in enterococci. Tribuna

Medica 99:137-48 (1999). 2. *ARIAS, CA., Panesso, D., Zuñiga M. Guidelines for the rational use of β-lactam

antibiotics: resistance mechanisms and their clinical implication. Biomédica 23:134-40 (2003).

3. ARIAS, CA., Murray, BE. Management of drug-resistant enterococcal infections. Expert Reviews on Anti-Infective Therapy 6:637-55 (2008).

4. ARIAS, CA., Murray, BE. Superbugs in the 21st century: A clinical super-challenge. New England Journal of Medicine 360:439-43 (2009).

5. *ARIAS, CA., Contreras, GA., Murray, BE. Management of multi-drug resistant enterococcal infections. Clinical Microbiology and Infection 16:555-62 (2010).

6. *Naninni, E., Murray, BE., ARIAS, CA. Resistance or decreased susceptibility to glycopeptides, linezolid and daptomycin in methicillin-resistant Staphylococcus aureus. Current Opinion in Pharmacology 10:516-521(2010).

7. ARIAS, CA., Murray, BE. The rise of enterococci: Beyond vancomycin-resistance. Nature Reviews Microbiology 10:266-278 (2012).

8. ARIAS, CA., Mendes, RE., Stilwell, M., Jones, RN., Murray, BE. Unmet needs and prospects for oritavancin in the treatment of VRE infections. Clinical Infectious Diseases 54 (Suppl 3):S233-S238 (2012).

9. Munita, JM, ARIAS, CA, Murray, BE. Enterococcal endocarditis: can we win the war? Current Infectious Diseases Reports 14:339-349 (2012).

10. Munita, JM, ARIAS, CA., Murray, BE. Enterococcus faecalis infective endocarditis: Is it time to abandon aminoglycosides? Clinical Infectious Diseases 56:1269-72 (2013).

11. *Rincón, S., Panesso, D., Díaz, L., Carvajal, LP., Reyes, J., Munita, JM., ARIAS, CA. Resistance to "last resort" antibiotics in Gram-positive cocci: The post-vancomycin era. Biomedica 34 Suppl 1:191-208 (2014).

12. Nigo, M., Munita, JM., ARIAS, CA., Murray, BE. What’s new in the treatment of enterococcal endocarditis? Current Infectious Disease Reports. 16:431 (2014).

13. *Miller, WR., Munita, JM., ARIAS, CA. Mechanisms of antibiotic resistance in enterococci. Expert Reviews of Anti-Infective Therapy. 12:1221-36 (2014).

14. *Munita, JM., Murray, BE., ARIAS, CA. Daptomycin for the treatment of bacteremia due to vancomycin-resistant enterococci. International Journal of Antimicrobial Agents. 44(5):387-395 (2014).


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15. ARIAS CA., Murray, BE. A novel antibiotic and the evolution of resistance. New England Journal of Medicine 372:1168-70 (2015).

16. *ARIAS CA., Rice, LB. A new AAC section: Translating resistance to the bedside. Antimicrobials Agents and Chemotherapy 59:4365 (2015).

17. McKinnell JA, ARIAS, CA. Linezolid vs daptomycin for vancomycin-resistant enterococci: The evidence gap between trials and clinical experience. Clinical Infectious Diseases 61;6:879-82 (2015).

18. *Munita, JM., Bayer, AS., ARIAS, CA. Evolving resistance among Gram-positive pathogens. Clinical Infectious Diseases 61;suppl2:S48-57 (2015).

19. *Tran, TT., Munita, JM., ARIAS, CA. Mechanisms of drug resistance: Daptomycin resistance. Annals of the New York Academy of Sciences 1354;1:32-53 (2015).

20. *Miller WR, Murray BE, Rice LB, ARIAS CA. Vancomycin-Resistant Enterococci: Therapeutic Challenges in the 21st Century. Infectious Diseases Clinics of North America. 30:415-39 (2016).

21. *Tran TT, Miller WR, Shamoo Y, ARIAS CA. Targeting cell membrane adaptation as a novel antimicrobial strategy. Current Opinion in Microbiology. 33:91-96 (2016).

22. *Munita JM, Shelburne S, Greenberg DE, ARIAS CA. The Growing Threat of Antimicrobial Resistance. Texas Medicine 113(2):48-52 (2017).

23. Doernberg SB, Lodise TP, Thaden JT, Munita JM, Cosgrove SE, ARIAS CA, Boucher HW, Corey GR, Lowy FD, Murray B, Miller LG, Holland TL; Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG). Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group. Clinical Infectious Diseases. 15;64(suppl1):S24-S29 (2017).

24. *Khan A, Miller WR, ARIAS, CA. Mechanisms of antimicrobial resistance among hospital-associated pathogens. Expert Reviews on Anti-infective Therapy. 16(4):269-287 (2018).

C. BOOKS AND BOOK CHAPTERS

1. Guzman, Y., Quintero, GA., Cuervo, JE., ARIAS, CA. and Escallon. J. Organ procurement

at the Fundación Santa Fe de Bogotá 1988-1993. In Anuario Fundación Santa Fe de Bogotá. Quintero, G.A., Restrepo, S., Rodriguez, E. et al (eds) p.p. 41-43 (1993).

2. Cuervo, J., Quintero, GA., McMaster, P., ARIAS, CA. Coagulation profile in liver transplant patients. In Anuario Fundación Santa Fe de Bogotá. Quintero, G.A., Restrepo, S., Rodriguez, E. et al (eds) p.p.73-77 (1993).

3. Quintero, GA., Escallon, J., Vera, A., Cuervo, JE ., ARIAS, CA . Sulbactam - Ampicillin in the treatment of intra-abdominal infections. In Anuario Fundación Santa Fe de Bogota. Quintero, G.A., Restrepo, S., Rodriguez, E. et al (eds) p.p.14-17 (1993).

4. ARIAS, CA., Quintero, GA., Cuervo, JE., Escallon, J. Prophylaxis in clean surgery. Is it justified? In Anuario Fundación Santa Fe de Bogota.Quintero, G.A., Restrepo, S., Rodriguez, E. et al (eds) p.p.130-132 (1993).

5. ARIAS, CA., Torres, CN., and Rodriguez, FA. Heat shock proteins: cellular response to stress. In Anuario Fundación Santa Fe de Bogotá. Quintero, G.A., Restrepo, S., Rodriguez, E. et al (eds) p.p.151-156 (1993).

6. Forero-Dueñas, CA., Sandoval-Huertas, L., ARIAS, CA. Compendium of the Research Activity of Colombians in the United Kingdom. Londsdale Press Ltd., London, UK. (1998)

7. ARIAS, CA. Resistance to glycopeptides in Gram-positive cocci. Surgical Infections. In Surgical Infections. Quintero G.A, Nieto J.A. and Lerma C.H. (eds)., Panamericana Internacional,. p.p. 111-118 (2001).


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8. ARIAS, CA. Murray, BE. Antibiotic resistance in enterococci. In UpToDate, Rose BD (ed.). Wellesley, MA. (2004-2014).

9. ARIAS, CA., Murray, B.E. Enterococcus species, Streptococcus bovis and Leuconostoc species. In Principles and Practice of Infectious Diseases. Mandell, GL., Bennett, JE., Dolin, R (eds). 7th Edition. Elsevier Inc., USA., pp. 2643-2653 (2009).

10. Mendoza, N., Arora, A., ARIAS, CA., Hernandez, CA., Madkam, V., Tyring, SK. Cutaneous and subcutaneous mycoses. In Clinical Mycology. Annaisse EJ., McGinnis, MR., Pfaller, MA. (eds). Churchil Livingstone, Elsevier, Ltd. UK., p.p.509-524 (2009).

11. ARIAS, CA . Design A Case (www.designacase.org). Fever on unknown origin (2010). 12. ARIAS, CA., Karchmer, AC. Prevention of antibiotic resistance, current and future

approaches. In Management of Infections in Cancer Patients. Safdar, A (ed). pp. 507-520 (2011).

13. Contreras, G.A., ARIAS, CA. Resistance of sexually transmitted diseases to antibacterials and antivirals. In Sexually transmitted diseases. Gross, D., Tyring, SK (eds). Springer, UK. 1st Ed. pp. 651-667 (2011).

14. Contreras, GA., ARIAS, CA. Clinical aspects of enterococci. In Antibiotic Discovery and Development. Pucci, M., Dougherty, TJ. (eds). Springer Inc., UK. pp. 617-650 (2011).

15. ARIAS, CA., Murray, BE. Enterococcal infections. In Harrison’s Principles of Internal Medicine. Longo, DL, Fauci, AS., Kasper, DL., Hauser, SL., Jameson, JL., Loscalzo, J. (eds). 18th Ed. pp. 1180-1186 (2011).

16. Miller, W., Murray, BE., ARIAS, CA. Emergence and management of drug-resistant enterococcal infections. In Microbial Drug Resistance. V. Krcméry (ed). www.futuremedicine.com pp. 41-53 (2013).

17. ARIAS, CA., Murray, BE. The Enterococcus and Streptococus gallolyticus. In Clinical Decision Support: Infectious Diseases. Karchmer, AW., Soutwick, F., Wenzel, R., Frank, I (eds). E-service (2013).

18. Kristich, CJ., Rice, LB., ARIAS, CA . Enterococcal infection – treatment and antibiotic resistance. In The Enterococcci, Enterococci: From Commensals to Leading Causes of Drug Resistant Infection. Gilmore M., Clewel DB., Ike Y., Shankar, N. (eds). DOI: http://www.ncbi.nlm.nih.gov/books/NBK190420/ (2014).

19. Munita, JM., ARIAS, CA . Vancomycin-resistant enterococcal infections in the ICU. In Infections in Critical care. Calsini et al (eds). Argentinian Society of Critical Care. (2014)

20. ARIAS, CA., Murray, B.E. Enterococcus species, Streptococcus gallolyticus and Leuconostoc species. In Principles and Practice of Infectious Diseases. Mandell, GL., Bennett, JE., Dolin, R (eds). 8th Edition. Elsevier Inc., USA., 2328-2339. (2014)

21. Nannini, E., ARIAS, CA., Murray, BE. Glycopeptides (vancomycin and teicoplanin), streptogramins (quinupristin-dalfopristin), lipopeptides (daptomycin), and lipoglycopeptides (Telavancin). In Principles and Practice of Infectious Diseases. Mandell, GL., Bennett, JE., Dolin, R (eds). 8th Edition. Elsevier Inc., USA., pp. 377-400 (2014)

22. Contreras, GA., Murray, BE., ARIAS, CA. Staphylococcus aureus. In Enfermedades Infecciosas. O. Vesga., Velez, LA., Leiderman, E., Restrepo, A (eds). (2015)

23. Contreras, GA., ARIAS, CA ., Murray, BE.. Enterococcal infections. In Enfermedades Infecciosas. O. Vesga., Velez, LA., Leiderman, E., Restrepo, A (eds). (2015)

24. Munita, J., ARIAS, CA. Skin and soft tissue infections. In Enfermedades Infecciosas. O. Vesga., Velez, LA., Leiderman, E., Restrepo, A (eds). (2015).


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25. ARIAS, CA., Murray, BE. Enterococcal infections. In Harrison’s Principles of Internal Medicine. Longo, DL, Fauci, AS., Kasper, DL., Hauser, SL., Jameson, JL., Loscalzo, J. (eds). 18th Ed. P.p. 971-976 (2015).

26. Miller WR, Bayer AS, ARIAS CA. Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci. Cold Spring Harb Perspect Med. Aug 31. pii: a026997 (2016).

27. Munita, JM., ARIAS, CA. Mechanisms of antibiotic resistance. In Virulence Mechanisms of Bacterial Pathogens. Zhang, Q (Ed). Microbiol Spectr. 2016 Apr;4(2). VMBF-0016-2015.

28. Araos, R., Munita, JM., ARIAS, CA. Antimicrobial resistance: selection vs. induction. In Antibiotic Resistance. Rice, LB. (ed) (2016). In press

D. WEB-BASED PUBLICATIONS AND LEARNING TOOLS

1. Arias, CA. Design A Case (www.designacase.org). Fever on unknown origin (2010). 2. Arias, CA., Murray, BE. The Enterococcus and Streptococus gallolyticus. In Clinical

Decision Support: Infectious Diseases. Karchmer, AW., Soutwick, F., Wenzel, R., Frank, I (eds) (2013).

3. Munita, JM., ARIAS, CA. The antimicrobial resistance crisis in Latin America. https://longitudeprize.org/blog-post/antimicrobial-crisis-latin-america

E. PROFESSIONAL COMMUNICATIONS AS INVITED SPEAKER

1. 4th Symposium on Antimicrobial Resistance, Cartagena, Colombia. Feb, 2006. 2. XXIII Chilean National Infectious Disease Conference and VI Meeting of Infectious Disease

Specialists of the South Cone. Viña del Mar, Chile. Nov 8 -10, 2006. 3. Colombian Society for Infectious Diseases, VIII Annual Meeting. Bogotá, Colombia, May 30

- Jun 2, 2007. 4. 5th Symposium on Antimicrobial Resistance, Cartagena, Colombia. Mar 4-7, 2008 5. Colombian Society for Infectious Diseases, IX Annual Meeting. Cali, Colombia, May 27-Jun

2, 2009. 6. European Society for Clinical Microbiology and Infectious Diseases (ESCMID) and

American Society for Microbiology. Conference on antimicrobial resistance among bacterial pathogens: mechanisms, detection and molecular epidemiology, Caracas, Venezuela. June 12-13, 2009.

7. Baylor College of Medicine, Texas Children Hospital, Infectious Diseases Fellowship Program. Invited speaker. June, 2009.

8. Latin American Society of Pediatric Infectious Diseases and Ecuadorian Society for Infectious Diseases. XIII Latin American Conference on Pediatric Infectious Diseases Meeting (SLIPE), Guayaquil, Ecuador. August, 2009.

9. Baylor College of Medicine. St. Luke’s Episcopal Hospital Grand Rounds. August, 2009. 10. Universidad El Bosque, UniBosque Global Alumni Annual Meeting, Washington, DC.

August, 2009. 11. Thomas Street Clinic, HIV Center for Clinical Research, University of Texas Medical School

at Houston and Baylor College of Medicine, Houston, TX. September 2009.


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12. Venezuelan Society for Infectious Diseases. XVII Annual Meeting, Maracaibo, Venezuela. October, 2009.

13. European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Conference on Enterococci: from Animals to Man. Barcelona, Spain. Nov 18 – 20, 2009.

14. 6th Symposium on Antimicrobial Resistance, Cali, Colombia. Mar 1-4, 2010. 15. Latin American Infectious Diseases Summit. Panama City, Panama. May 13-15, 2010. 16. Cold Spring Harbor Laboratory/ Wellcome Trust. Infectious Diseases and Global Health.

Hinxton, Cambridge. Sep 12 – 15, 2010. 17. Universidad El Bosque, 10th Anniversary, Molecular Genetics and Antimicrobial Resistance

Unit. Key Note Speaker, Bogota, Colombia. Oct 29, 2010. 18. Caribbean Association of Clinical Microbiologists (CACM). 7th Annual General Meeting and

Symposium. Barbados, Nov 4-7, 2010. 19. Annual Meeting of the Chilean Infectious Diseases Society. Valdivia, Chile. Nov 17-19,

2010. 20. Colombian Symposium on Antimicrobial Resistance, Cali, Colombia. January 26, 2011. 21. Houston Infectious Disease Network (Doctors in Pharmacy) University of Houston,

February 8, 2011. 22. Antimicrobial Resistance Discussion Panel, World Health Day. University of Texas,

School of Public Health. Houston, TX. April 17, 2011. 23. American Society for Microbiology, General Meeting. Plenary Symposium, Antimicrobial

resistance: molecular mechanisms and clinical consequences. New Orleans, LA. May, 23, 2011.

24. Colombian Society for Infectious Diseases, XI Annual Meeting. Medellin, Colombia, July 15 -19, 2011.

25. MD Anderson Cancer Center, Division of Infectious Diseases and Employee Health. Invited Speaker – Research Symposium, Houston. July 26, 2011

26. IX Critical Care World Congress. Panamerican Society for Critical Care. Cartagena, Colombia, Dec 13, 2011.

27. International Symposium on Antimicrobial Resistance, Cartagena, Colombia. Mar, 2012. 28. Baylor College of Medicine, Microbiology and Molecular Virology Seminar, Houston, TX.

Mar, 2012. 29. Universidad El Bosque, Distinguished Alumni Lecture, Bogota, Colombia July, 2012. 30. Chilean Society for Intensive Medicine. XXX Annual Congress. Coquimbo, Chile. October

24 – 27, 2012. 31. French Society for Microbiology, Bacterial Organisms and Resistance Symposium. Institute

Pasteur, Paris December 5, 2012. 32. Brazilian Society for Microbiology. XXIII Symposium on Antimicrobial resistance, Sao

Paulo, Brazil, March 25th, 2013. 33. Annual Symposium on Antimicrobial Resistance, Chilean Infectious Disease Society, Santa

Cruz, Chile, April 3-4, 2013. 34. XI Annual Meeting, Colombian Society for Infectious Diseases, Cartagena, Colombia, May

22-24, 2013.


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35. XVI Meeting, Panamerican Society for Infectious Diseases, Santiago, Chile. May 28-31, 2013.

36. CIDEIM Antibiotic Resistance Workshop, Cali, Colombia, Sep 6-7, 2013. 37. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). American

Society for Microbiology, Denver, CO., Sep 9-13, 2013. 38. Texas Fresh Air, 2013. University of Texas System; Inaugural Meeting. Austin, TX., Sep

25-26, 2013. 39. Infectious Disease Society of America. 2013, IDWeek Annual Meeting, San Francisco, CA,

Oct 1-6, 2013. 40. Universidad Del Desarrollo and Clinica Alemana de Santiago. Genomic Medicine

Symposium. Santiago, Chile. Nov 4-7, 2013 41. Costa Rican Society for Microbiology, Annual Meeting 2013. San Jose, Costa Rica. Nov

11-12, 2013. 42. American Society for Microbiology. 4th International ASM Meeting on Enterococci,

Cartagena Colombia, March 5-7, 2014 (Chair and Organizer). 43. Antimicrobial Resistance Symposium. Colombian Society for Infectious Diseases and

International Center for Medical Research (CIDEIM). Buga, Colombia. Apr 25-26, 2014 44. Medical World Americas, Houston, TX. Apr 27, 2014. 45. Aurora St Luke’s Medical Center, Milwaukee, MO. Grand Rounds. May 9, 2014. 46. Sao Paulo Infectious Disease Society. 9th Annual Symposium. Sao Paulo, Brazil. May 21-

24, 2014. 47. Argentinian Society for Infectious Diseases, 14th Annual Meeting. Rosario, Argentina. May

29-31, 2014 48. Kansas Society of Dermatology and Dermatological Surgery. 2014, Annual Conference.

Kansas, MO. Aug 23, 2014. 49. COLMEDICA, Annual Medical Meeting: New Medical Challenges in the 21st Century.

(Keynote speaker) Bogota, Colombia, Aug 28, 2014. 50. American Society for Microbiology, Interscience Conference on Antimicrobial Agents and

Chemotherapy (ICAAC)., Washington, DC., Sept 5-9, 2014. 51. Infectious Disease Society of America. 2014, IDWeek Annual Meeting, Philadelphia, PA,

Oct 1-6, 2013. Oct 8-12, 2014. 52. Latin American Society for Microbiology (ALAM). 2014 ALAM Meeting, Cartagena,

Colombia. Nov 5-8, 2014. 53. Panamerican Society of Infectious Diseases. 17th Meeting of the Panamerican Society for

Infectious Diseases. Quito, Ecuador. May 16-19, 2015. 54. IDIBELL Seminar. International guest Speaker. Hospital Belvitge, University of Barcelona,

Barcelona, Spain. June 5, 2015. 55. Colombian Infectious Disease Society. Annual Meeting. August 12-15, 2015 56. American Society for Microbiology, Interscience Conference on Antimicrobial Agents and

Chemotherapy (ICAAC), San Diego, CA., Sept 18-21, 2015. 57. Infectious Disease Society of America. IDWeek Annual Meeting, San Diego, CA. Oct 5-10,

2015. 58. Wellcome Trust Conference on Infectious Disease Genomics. Hinxton, UK. October 14-16,

2015.


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59. Oxford Department of Microbiology, NHS Trust. Oxford, UK. October 21, 2015. 60. Columbia University, Combating the Rise and Spread of Antibiotic-Resistant

Microorganisms in the Americas: Formation of a Collaborative Network on Antimicrobial Resistance Network in Latin America. Santiago de Chile, December 2-3, 2015.

61. 2016 EUROPE – NORDIC – U.S. SYMPOSIUM: “New Frontiers in Antibacterial Resistance Research”. Stockholm, Sweden. January 20-21, 2016

62. International Symposium on Antimicrobial Resistance, Cali, Colombia, March 2-5, 2016. 63. University of Texas Medical Branch, Galveston, TX. Invited Professor. Grand Rounds,

March 17, 2016. 64. Universidad El Bosque, Bogota, Colombia. International Symposium on Microbial

Genomics, May 11-13, 2016 65. Mexican Infectious Diseases Society. Annual Meeting Monterrey, Mexico. May 26-28,

2016. 66. ASM Microbe. American Society of Microbiology, Annual Meeting. Boston, USA. June 16-

20, 2016. 67. Advanced Infectious Diseases Symposium. Mexican Society of Infectious Diseases.

Queretaro, Mexico, July 8-10, 2016. 68. International Symposium on Staphylococci and Staphylococcal Infections. Seoul, Korea.

Aug 29-Sept 3, 2016. 69. IDSA/Center for Disease Dynamics and Economic Policy. High-level meeting preceding the

UN general assembly. IDSA representative. New York, NY. Sep 20, 2016. 70. Institut Pasteur/Fondation Merieux. Advanced Course on Antibiotics. Veryer du Lac,

France. October 8-19, 2016. 71. Infectious Disease Society of America. IDWeek Annual Meeting, New Orleans, LA. Oct 5-

10, 2016. 72. Colombian Society of Hospital Infection. Annual Symposium, Cali, Colombia, March 15-17,

2017. 73. ASM Microbe. American Society of Microbiology, Annual Meeting, New Orleans, LA, June

1-5, 2017. 74. Oxford University, Nuffield Department of Medicine. Clinical and Research Seminars.

Invited speaker. Oxford, England, July, 2017. 75. XIII Colombian Congress on Infectious Diseases. Barranquilla,Colombia. August 9-11,

2017. 76. Innovation Forum for ID Week 2017. Washington, D.C., August 17-18, 2017. 77. Symposium on Antimicrobial Resistance” A Multifaceted Approach to the Future. Invited

Speaker. Santiago, Chile, September 4-8, 2017. 78. Annual Meeting of the Brazilian Infectious Diseases Society. Rio de Janeiro, Brazil,

September 11-14, 2017. 79. Symposium on Antimicrobial resistance: A multifaceted approach to resistance. October 6-

8, 2017. Santiago de Chile, Chile. 80. Research Congress 2017. Universidad El Bosque. Bogota, Colombia, September 19-21,

2017.


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81. Infectious Diseases Society of America (IDSA). IDWeek Annual Meeting. San Diego, CA, October 2-8, 2017.Member of the program committee.

82. 13th Biennial “Bridging the Career Gap: Promoting Diversity in Biomedical Research. Invited Key Note Speaker. Rockville, MD, October 11, 2017.

83. X International Symposium on Antimicrobial Resistance. Bogota, Colombia. March 7-9, 2018.

84. Institute for Public Health Global Center’s Annual Conference: Global Challenge of Antimicrobial Resistance. St. Louis, Missouri, April 6, 2018.

85. The 28th European Congress of Clinical Microbiology and Infectious Diseases. Madrid, Spain, April 18-24, 2018.

86. ASM Microbe. Atlanta, Georgia, June 8-11, 2018. 87. Central American and Caribbean Congress of Infectology. San Jose, Costa Rica, June, 13-

16, 2018. 88. CURB: Antibacterial Resistance Symposium. Santiago, Chile. August 18-24, 2018. 89. Internal Medicine Grand Rounds, Invited Visiting Professor, University of Miami, Miller

School of Medicine, Miami, FL, September 5th, 2018 90. Infectious Diseases Grand Rounds. Visiting Professor. University of Texas Southwestern

Medical Center, Dallas. September 12th, 2018 91. The challenge of XDR infections Workshop. Barcelona, Spain, September 14, 2018 92. Universidad El Bosque, Annual Research Symposium, Bogota, Colombia, September 19,

2018

I. RELEVANT MEDIA EXPOSURE

- Television

Date: Nov, 2008 Type: Interview Topic: “Antibiotic-resistant bacteria” (following publication of NEJM article) Interviewer: Lenn Cannon Program: Channel 11 News Channel: KHOU, Channel 11, Houston Date: Jan, 2009 Type: Interview Topic: “Antibiotic-resistant superbugs” (following publication of “Perspective” in NEJM) Interviewer: Christi Myers Program: Channel 13 News Channel: Channel 13, Houston Date: Sept 7, 2011 Type: Interview Topic: “Genomic analysis of superbug provides clues to antibiotic resistance” Interviewer: N/A Program: Telemundo Channel 47


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Channel: Channel 47

- Radio

Date: Feb 2, 2009 Topic: MRSA Infections Interviewer: Claudia Hammond Show: “Health Check” Radio Station: BBC World Service Date: Sept 7, 2011 Topic: “Genomic analysis of superbug provides clues to antibiotic resistance” Interviewer: N/A Show: CNN Radio Radio Station: CNN Radio Date: Sept 13, 2011 Topic: “Genomic analysis of superbug provides clues to antibiotic resistance” Interviewer: N/A Show: Radio Caracol Radio Station: Radio Caracol Date: Dec. 13, 2016 Topic: How do we prepare for a “post-antibiotic world?” Interviewer: NA Show: Houston Matters Radio Station: Houston Public Media 88.7 FM Date: March 14, 2018 Topic: History of antibiotic use and the latest research on antibiotic resistance Show: Houston Matters Radio Station: Houston Public Media 88.7 FM

- Print and Websites Date: Nov 11, 2008 Publication: CNN.com/health Website: http://articles.cnn.com/2008-11-14/health/superbugs.samerica_1_mrsa- infections-staphylococcus-colombia? _s=PM:HEALTH Date: Nov 12, 2008 Publication: ErukAlert.com Website: http://www.eurekalert.org/pub_releases/2008-11/uoth-ub111208.php Date: Nov 13, 2008 Publication: Science Daily Website: http://www.sciencedaily.com/releases/2008/11/081112194922.htm Date: Nov 14, 2008


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Publication: BBCMundo.com Website: http://news.bbc.co.uk/hi/spanish/science/newsid_7727000/7727895.stm Date: Dec 12, 2008 Publication: SEMANA.com and print edition Website: http://www.semana.com/noticias-vida-moderna/alerta-llegaron-superbacterias/118492.aspx Date: Feb 3, 2009 Publication: Environment news service Website: http://www.ens-newswire.com/ens/feb2009/2009-02-03-01.html Date: Oct, 2010 Publication: Nature Medicine (Print Edition) Website: http://www.nature.com/nm/journal/v16/n10/full/nm1010-1054a.html

Date: Sept 7, 2011 Publication: The New England Journal of Medicine Website: http://www.nejm.org/

Date: Sept 8, 2011 Publication: Science Daily Website: http://www.sciencedaily.com/releases/2008/11/081112194922.htm Date: Match 1st, 2014 Publication: New York Times Website: http://NYT.com Date: December 6, 2016 Publication: Houston Chronicle Website: http://www.chron.com/opinion/outlook/article/Shelburne-Shamoo-and-Arias-We-must-be-smarter-1077870

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NAME PRESENT TITLE (s) Molecular Genetics UTHealth ... · International Journal of Antimicrobial Agents, Antimicrobial Agents and Chemotherapy, Journal of Antimicrobial Chemotherapy,