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Human Physiology and Alcohol. Physiology of Alcohol. The biological science of essential & characteristic life processes, activities & functions Endogenous Alcohol Absorption Distribution Elimination. Physiology Overview. Endogenous alcohol production Absorption Distribution - PowerPoint PPT Presentation
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Rev 3.09 5-1
Human Physiology and Alcohol
Rev 3.09 5-2
Physiology of Alcohol
• The biological science of essential & characteristic life processes, activities & functions
• Endogenous Alcohol
• Absorption
• Distribution
• Elimination
Rev 3.09 5-3
Physiology Overview
• Endogenous alcohol production
• Absorption
• Distribution
• Elimination• metabolism
• excretion
Rev 3.09 5-4
Routes of Alcohol
• Inhalation
• Injection
• Absorption
• Insertion
• Ingestion
Rev 3.09 5-5
Gastrointestinal Tract Absorption
• Mouth • 5 %
• Stomach • 25%
• Small Intestine • 70%
Absorption and Distribution
Rev 3.09 5-7
Absorption Process
• Passive process
• Migrate from HIGH concentration to LOW concentration
• Migrates as unchanged molecule
• Across cell membranes
• Enters blood supply- circulatory system to affect body
Rev 3.09 5-8
x x x x x x x x x x x x
x xGastric
Blood Stream
Cell Membrane
High Conc Low Conc
Migration of ETOH
Rev 3.09 5-9
Distribution
• Alcohol distributed throughout body by circulatory system blood supply
• Some organs receive more volume blood than others
• some organs and body parts have more water content than others
Rev 3.09 5-10
A person with a BrAC of 0.100…
• Urine 1.35%
• Brain 1.17%
• Blood Plasma 1.16%
• Saliva 1.12%
• Liver 0.91%
• Fat Tissue 0.02%
Distribution
Rev 3.09 5-11
ETOH Distribution Pathways
Representation of Ethyl Alcohol Distribution Pathways
Male vs Female
Each man consumes
One fluid ounce
Of Ethyl Alcohol
200# Male = 136% water 100# Male = 68% water
200# man must consume twice as much as the 100# man to attain the same alcohol concentration
100# male = 68% water 100# female = 55% water
______________________________________________________________________________________________
100 # male must consume more alcohol than the 100# female to attain the same alcohol concentration
More alcohol per pound of water in 100# male than 200# male
More alcohol per pound of water in 100# female than 100# male
Rev 3.09 5-13
Elimination (Part 1)
• Metabolism• Alcohol Dehydrogenase Enzyme ADH• Produced by liver
• Oxidizes or burns alcohol molecule
• 95-98% alcohol in body is metabolized
• Rate of 1 drink per hour, about 0.015
?? 0.150 BrAC how long to reach 0.000 BrAC ??
Rev 3.09 5-14
Elimination (Part2)
• Direct Excretion– Alcohol directly excreted or passed out of body
by:• Urine
• Sweat
• tears
• saliva
Rev 3.09 5-15
When drinking rate exceeds elimination rate, the brain becomes sedated
Alcohol In / Out
Rev 3.09 5-16
Widmark Formula
• Eric Widmark Swedish scientist
• Formula or Graph describes BAC level
• Describes different phases
• how many drinks in body at the time of the test
• Dose related concept
• Body weight
• %BAC x Body Weight x 0.33 = # of drinks
ESTIMATED AMOUNT OF 80 PROOF LIQUOR NEEDED TO REACH GIVEN LEVELS OF ALCOHOL IN THE BLOOD
Rev 3.09 5-18
Widmark Graph
• Three parts of blood alcohol curve– absorptive phase
– peak phase
– elimination phase
Rev 3.09 5-19Time
Peak
Elimination Phase
Absorption Phase
General Alcohol Concentration CurveA
lcoh
ol
Con
cen
tra t
ion
Rev 3.09 5-20
Factors affecting Widmark curve
• Food in the stomach
• Amount or number of drinks consumed
• Body weight
• Time
Rev 3.09 5-21
Elimination Rate*
7 PM 8 PM 9 PM 10 PM
11 PM
12 AM 1 AM 2 AM 3 AM 4 AM 5 AM 6 AM 7 AM
Absorption Elimination
.150
.100
.050
.000
.080
* 150 LBS person drinking on an empty stomach
.150
.100
.080
.050
.000
Hours 1 2 3 4 5 6 7 8 9 10
11
12
Stops Drinking
.090
.120
Legally Intoxicated
Legally Impaired
Rev 3.09 5-22Time
EMPTY STOMACH
FULL STOMACH
Ethanol Absorption: Effect of Food in the Stomach
Alc
ohol
C
once
ntr
a tio
n
Rev 3.09 5-23
Dose Related
10 DRINKS
5 DRINKS
TIME
Alc
ohol
C
once
ntr
a tio
n
Rev 3.09 5-24
110 LBS
220 LBS
TIME
Body Weight
Alc
ohol
C
once
ntr
a tio
n
Rev 3.09 5-25
10 DRINKS
ONE HOUR
10 DRINKS TEN HOURS
TIME
Time Related
Alc
ohol
C
once
ntr
a tio
n
Rev 3.09 5-26Time
Arrest Test
Alc
ohol
C
once
ntr
a tio
n
Alcohol Concentration LOWER at the Time of Test than at Time of Arrest
Rev 3.09 5-27Time
Arrest Test
Alc
ohol
C
once
ntr
a tio
n
Alcohol Concentration THE SAME at the Time of Test and Arrest
Rev 3.09 5-28
Arrest Test
Alc
ohol
C
once
ntr
a tio
n
Time
Alcohol Concentration HIGHER at the Time of Test than Time of Arrest
Rev 3.09 5-29
PHARMACOLOGY OF ALCOHOL
EFFECTS OF ALCOHOL ON THE HUMAN BODY
Rev 3.09 5-31
EFFECTS OF ALCOHOL
• DEPRESSANT - NOT A STIMULANT• DOSE RELATED
• more drinks,greater influence, increased impairment
• AFFECTS CENTRAL NERVOUS SYSTEM• brain
Myths vs Facts
alcohol It is a Stimulant
It has Nutrients
It increases Mental and
Physical ability
In given amounts alcohol
affects individuals in the
same way
There are ways to sober
up quickly
Any amount will cause
bodily damage
It is a Depressant
It has Calories
It decreases Mental and
Physical ability
In given amounts alcohol
affects individuals in different
ways
Time is the only way to sober
up
It will cause bodily damage if
consumed in excess
Greek & Roman Banquets
First Description of Effects of Wine by Eubulus
Health Revel
Pleasure Black Eyes
Sleep To Policemen
Violence Biliousness
Uproar Hurling Furniture
Rev 3.09 5-35
EFFECTS OF ALCOHOL
VISIBLE SIGNS
VS
INVISIBLE SIGNS
Rev 3.09 5-36
Sequ
ence of M
ental G
rowth
1 Vital Functions 3
2 Muscle Control 2
3 Higher Learning 1 Center
Pro
gres
sion
of
Eth
anol
’s S
edat
ive
Eff
ects
Ethanol and Your Brain
Higher Learning
Vital Functions
Muscle Control
Stages of Intoxication
Begins Ends
Sobriety 0.00 0.05
Euphoria 0.03 0.12
Excitement 0.09 0.25
Confusion 0.18 0.30
Stupor 0.27 0.40
Coma 0.35 0.50
Death 0.35 0.50
Rev 3.09 5-38
VISABLE SIGNS
• Confusion• Sleepiness• Disorderly/sloppy appearance• Slurred, thick tongued speech• Nausea • Red, flushed face• Glassy, watery eyes, staring
Rev 3.09 5-39
Rel
ativ
e P
rob
abil
ity
.00 .02 .04 .06 .08 .10 .12 .14 .16 .18
1
5
10
15
20
25
30
35
40
45
%BAC
Relative Probability
of Causing an Accident
The Role of Alcohol in Traffic Accidents(The Grand Rapids Study)
Rev 3.09 5-40
Rev 3.09 5-41
Physiology of RespirationVital Processes
• Function of Respiration
• Mechanism of Respiration
• Alveolar Sac
• Henry’s Law
Rev 3.09 5-42
Blood
Gas Exchange
C2H5OH Lung Space
Exchange of ETOH Between Blood & Breath
in the Alveolar Sacs of the Lungs
Rev 3.09 5-43
Air In /Air Out
Y
0
Rev 3.09 5-44
Henry’s Law:The vapor pressure that a gas exerts above a liquid is directly proportional to the weight of the gas dissolved in the liquid at 34° C.
• Chemical principle
• partitioning ratio between gas and liquid phase
• occurs at equilibrium• balance, no net change
• occurs at 34oC
• occurs in a breath sample
Rev 3.09 5-45
Henry’s Law
• Simulator at 34ºC
• alcohol and water mixture
• 1 to 2100 ratio for alcohol
• Similar to breath sample
• Higher temp = higher reading
• lower temp = lower reading
Rev 3.09 5-46
Liquid to Vapor
x xx x x x x xx x x x x x x xxx xxx xxx
Head Space – Measure alcohol in air
Measure liquid or alcohol in water using a
1/2100 proportion
2100 molecules
@ 34ºC equilibrium is reached between liquid and vapor
210L
100ml
x
2100 molecules
1 molecule
x x x x xx xx x x x xx xx xx xx x x
Rev 3.09 5-47
Alcohol in Solution Alcohol in Vapor
2100 molecules 1 molecule
4200 molecules 2 molecules
6300 molecules 3 molecules
8400 molecules 4 molecules
10500 molecules 5 molecules
21000 molecules 10 molecules
Henry’s Law
Rev 3.09 5-48
• The alcohol breath test based on Henrys Law• Breath sample is “End Expiratory Air” from
lungs• Partitioning ratio is 1 to 2100• Breath has 1/ 2100th as much alcohol as found
in blood • Blood has 2100 times as much alcohol as
breath
Henry’s Law
Rev 3.09 5-49
• Grams of alcohol per
• BrAC = 210 liters breath
• BAC = 100 mls of blood
• Reported as Weight per Volume
• grams alcohol /210 liters breath
• grams alcohol / 100 milliliters blood
Henry’s Law
Rev 3.09 5-50
Advantages of Breath Testing
• Immediate Results
• Lower Cost
• Non Invasive Procedure
• No Medical Personnel Needed
• Not Possible for Operator to Alter Results
• Fewer Witnesses for Court
Rev 3.09 5-51
Intoxilyzer BrAC = BAC
The ultimate proof that the Intoxilyzer is an accurate scientific instrument comes from research which shows that simultaneous Blood & Breath tests had similar results.
This type of research is also conducted using a simulator with a known alcohol content. This is the method used for checking the calibration of Intoxilyzers in Colorado.
Ultimate Proof
Rev 3.09 5-52