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Human Endocrine Physiology. February 13, 2014 Reprise: Hypothalamic-Pituitary Systems The Thyroid Axis The Adrenal Axis. Thyroid Physiology in Pregnancy. Importance for fetal development Changes in maternal thyroid stimulation Iodine deficiency. - PowerPoint PPT Presentation
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Human Endocrine Physiology
February 13, 2014
Reprise: Hypothalamic-Pituitary SystemsThe Thyroid AxisThe Adrenal Axis
Thyroid Physiology
in Pregnancy
•Importance for fetal development•Changes in maternal thyroid stimulation•Iodine deficiency
Balance Between TSH and hCG in Pregnancy
Maternal iodine important
TSHT4
+
-
Glycoprotein family of hormones
(hCG)
(TSH receptor)(hCG receptor)
TSH
T4+-
hCG+
Maternal iodine important
Iodine
T4*,T3
***Only T4 crosses the BBB
DI
***