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2020FEB
I nves torsp r e s e n t a t i o n
Table of contents
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 2
01. VALBIOTIS / Corporate
02. TOTUM-63, to reduce the risk of type 2 diabetes
03. TOTUM-070, to reduce hypercholesterolemia
04. TOTUM-448, to reduce non-alcoholic hepatic steatosis (NAFL)
05. TOTUM-854, to reduce arterial hypertension
06. FINANCIAL INFORMATION
A R&D company, committed to scientific innovation,for preventing and combating metabolic diseases
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 3
An original multitarget approach,enabled by the use of plants.
A first strategic partnership,a template of collaboration agreement for the developmentand commercialization, at a global level.
A need for prevention:to reduce the risk of major metabolic diseases.
A high level of evidence,with clinical studies and health claims.
4 patent families,a robust intellectual property worldwidethanks to a specific know-how of plants.
A pipeline of innovative productsgenerated by a proprietary R&D 1200m2 platform.
SCIENCE BUSINESSA new class of Nutrition Healthproducts to address unmet medical needs
A model validated by a first globaland long-term strategic partnership
Founded in 2014 3 locations France: Périgny, La Rochelle, Riom 36 employees: 75% in R&D; < 50% womenProprietary preclinical platformEuronext Growth (ALVAL)
A unique partnership in the field of Nutrition Health
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 4
+ Tiered royalties on net sales+ Supply revenues
Milestones payments: up to CHF 66 million
Upfront: CHF 5 million
A long-term strategic partnershipfor the development and worldwide commercialization
of TOTUM-63 in prediabetes
A worldwide contractsigned beforepivotal phase
Commercializationpossible priorto health claim
A license and supplyagreement
Joint Advisory Committee
The success of an innovative model in health industry,proven effective in only 5 years
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 5
• Foundation of VALBIOTIS
• Discovery of TOTUM-63:first studies and patent applications
• Initial Public Offering
• Internalization of the R&D platform
• First strategic partnershipwith a global healthcare player
• Development of other products of thepipeline following TOTUM-63 standard
• Clinical validation of the first product, TOTUM-63
23.7 M €raised since 2014 (equity)
36 collaborators1200m2 R&D platform in-house4 employees
+ academic partners
Up to 71 M CHFupfront and milestones paiements+ Royalties on net sales+ Supply revenue(1st partnership)• First fundraising
• Strategic patents grantedfor TOTUM-63
20142016
20172019
2020
An advanced pipeline, addressing unmet medical needs
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 6
A global IP strategy across the portfolio
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 7
Demonstrates that innovative combinations of plant extracts are patentablefor a healthcare purpose in food, supplements or pharmaceuticals products> “ Plant extracts / molecules ”.
All patents registered internationally, including USA, Europe, Canada, China, Australia, Russia, Japan, Brazil.
PATENT FAMILIES APPLICATIONS WORLDWIDE
- in the USA in 2018, with a triple protection:composition, method and use in the field of metabolic diseases.
National phases ongoing in more than 20 countries(incl. Canada, China, Australia, Japan, Brazil).
A STRATEGIC PATENT ALREADY GRANTED:
- in Europe in 2019, covering 39 countries. Patent applied forin + 60 countries
4- in Russia in 2020.
Solid scientific results selectedby major international scientific societies
Feb. 2020© NON CONFIDENTIAL - VALBIOTIS 8
communicationsduring
scientific congressessince 2016
Including 7 acceptedcommunications in the 3 major
diabetes congresses worldwide
3 selections by the Keystone Symposia
13
An expert management team for healthcare innovation
Feb. 2020 9
Sébastien PELTIER
20 years’ experience in Research& Development for drug and foodsupplement industries. Unique, proven experience with health claims referring to the reduction of a disease risk (EFSA – European Food Safety Authority – article 14.1a)
CEO, PhD - HDRChairman of the Boardof Directors
25 years’ experience in healthand nutrition. Founder and former Executive Director of Biofortis Mérieux NutrisciencesEurope.
Murielle CAZAUBIELM.ScCMO, Member of the board
Pascal SIRVENTPhD - HDRCSO, Member of the boardOver 15 years’ research experiencein the field of metabolic diseases, with leadership positions and a strong background in international scientific partnerships.
Laurent LÉVY, PhD Chairman of the Supervisory BoardRemuneration CommitteeCEO, co-founder,NANOBIOTIX
Agnès TIXIERAudit CommitteeInvestment Director, CM-CIC INVESTISSEMENT
SUPERVISORY BOARD
Sébastien BESSYRemuneration CommitteeVice President Global Strategic Operations, IPSEN
Dr Jean ZETLAOUI MD, MBAAudit CommitteeSpecial Scientific Advisor to the CEO, NOVARTIS PHARMA
Jocelyn PINEAUMBACFO, Member of the board20 years’experience in projectmanagement positions as partof executive management boards,in the agro-food and food supplementsindustries.
Medicine degree, 25 years’ international expérience in marketing and business development focused on Consumer Healthcare, with top management positions. Former Vice President at Sanofi, Johnson & Johnson and Pfizer. *
Josep INFESTAMD, MBAHEAD OF GLOBAL BUSINESS DEVELOPMENT
Finance & administration Discovery, preclinicaland translational
research
Development and medical affairs Global Business
Development
* External consultant
© NON CONFIDENTIAL - VALBIOTIS
High-value scientific & medical supervisory Board
Feb. 2020 10
Pr. Jean-Marie BARD PharmD, PhD, PU-PH – Nantes University Hospital
Professor of biochemistry at the Faculty of Pharmacyand Head of the Biopathology Department at Institut
de Cancérologie de l’Ouest (ICO) in Nantes.
Pr. Samy HADJADJ MD, PhD, PU-PH - Nantes University Hospital
Professor of endocrinology, diabetology and metabolic diseases, Hospital practitioner.
André MARETTEPhD - Laval University Hospital INAF (Canada)Professor in the Faculty of Medicine. Researcher at the Quebec Heartand Lung Institute and Scientific Director of the Institute of Nutritionand Functional Foods (INAF) at Université Laval.
Nathalie BOISSEAU PhD, PU - Clermont Auvergne UniversityProfessor of sports physiology.
Thierry MAUGARDPhD, PU - La Rochelle UniversityProfessor of biochemistry inthe Biotechnology Department.
Bruno GUIGASPhD - Leiden University (Netherlands)
Assistant professor.
© NON CONFIDENTIAL - VALBIOTIS
A proprietary platform dedicated to metabolic diseases
Feb. 2020 11
In vivo screeningon relevant models of metabolicdiseases
1,200 m2 platform: models of metabolic diseases, radiolabelling, micro-surgery & clamp, histology,cellular culture, molecular biology, biochemistry.
Design ofactive substances(compliant withpharmacopeiaUS / EU)
Extraction processes,characterisation, purification, bio-engineering, pharmaco-modulation.
In vivo and in vitro studies:efficacy, safety,mode of action
Plant-basedchemistry & preclinical research
Discovery
© NON CONFIDENTIAL - VALBIOTIS
A high level of evidence for prevention
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 12
A R&D processfollowing the outline
of pharmaceuticaldevelopment
Health claims:well established regulatory processes
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 13
Set product specifications
and quality management.
Provide non-ambiguous proof of the efficacy
of the product in at-risk population,
according to current regulation.
HEALTH CLAIMS
F O O D S U P P L E M E N T S TAT U S NATURAL HEALTH PRODUCT
Different framesamong countries
“TOTUM-63 may reducethe risk of type 2 diabetes,
a disease associatedwith several risk factors.”
”TOTUM-63 reducesfasting glycemia,
which increase is a risk factorfor type 2 diabetes.”
Free claim, but strictlycompliant with clinical evidence.
Composition, quality& safety
Composition, quality± safety
Quality + evidence regardingsafety and efficacy
The business model
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 14
TARGET POPULATIONSubjects at risk of developingmetabolic diseases
PRESCRIBERS / ADVISORSHealthcare professionals
RETAILPharmacies / drugstoresnetwork, web+ ad hoc omnichannelstrategy by country
COM
MER
CIA
LIZA
TIO
N M
OD
EL
Upfront and milestones paymentsFunding of clinical studies
Royalties on salesSupply
LONG TERM STRATEGIC PARTNERSHIP
Global agreements along the products life cycle:- Last stages of clinical development- Galenic development and supply- Worldwide commercialization
REVENUE GENERATING GROWTH
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 15
4 Nutrition Health productsin clinical development stages,to reduce the risk of developing metabolic diseases
TOTUM-63,to reduce the risk of type 2 diabetes
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 16
Prediabetes: an opportunity for diabetes prevention
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 17
“Prediabetes should not be considered as a diseasebut as a high-risk stage of developing T2 diabetes 1”
1 Standards of care in Diabetes, ADA 2017 ; 2 Tabak AJ. et al., Lancet, 2012 ; 3 Nathan DM. et al., Diabetes Care, 2007 ; 4 Knowler WC et al., N Engl J Med, 2002
Reversible metabolicimpairments
Irreversible metabolicimpairments
in most cases
PREDIABETESAT- R I S K S TA G E TYPE 2 DIABETES
Lifelong treatments,costful and stressful follow-up+ morbid complications
RISK OF PROGRESSION TO TYPE 2 DIABETES WITHOUT INTERVENTION
PREDIABETES1 year5% to 10%2
3-4 years25% to 37%3,4
Long term70% to 90%2
Prediabetes: a favourable medical environment for new products
18
Standards of care in Diabetes, ADA, 2017 ; Global Report on Diabetes, WHO, 2016 ; HAS – Référentiel de pratiques de l’examen périodique de santé, Prévention et dépistage du diabète de type 2, 2014
An easy diagnosis in primary care, based on simple blood tests:
Feb. 2020
And / Or
Moderate fasting hyperglycemiaFasting glycemia from 1.00 to 1.25 g/L
Or HbA1c ≥ 5.7% and < 6.5%
Screening and diagnosis modalities
Recommendations for prediabetes management
A recognition by international scientificsocieties and health authorities
Impaired glucose toleranceGlycemia from 1.4 to 2.0 g/L,
2 hours after a 75 g oral glucose intake
Moderate fasting hyperglycemiaFasting glycemia from 1.10 to 1.25 g/L
Impaired glucose toleranceGlycemia from 1.4 to 2.0 g/L,2 hours after a 75 g oral glucose intake
And / Or
© NON CONFIDENTIAL - VALBIOTIS
TOTUM-63: an innovative active substance, patented,based on a plant-based combination
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 19
Complete characterisationof the biomolecules
(HPLC-UV/MS)
Combinationof 5 alimentaryplant extracts
I N T E L L E C T U A L P R O P E RT Y
Patent family VALBIOTIS.001(plant extracts / molecules)
Patents granted in 41 countriesincl. Europe (39 countries) USA and Russia.
National phases ongoing in + 20 countries,incl. key territories: Canada, China, Brazil, Japan, Australia.
VALEDIA®: a worldwide innovation designed for people with prediabetes
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 20
Clinical evidence of efficacy already obtained in prediabetics, for the reductionof fasting glycemia, to obtain a healthclaim for the risk reduction of type 2 diabetes
Already marketable in Europe, with authorizations granted, related to its status.
Different formulations: capsules, powder, or integrated into medical nutrition products.
100% natural, perfect tolerance.
First clinically proven and natural solutioncreated to reduce the risk of developing type 2 diabetes
Adipose tissue
Increases peripheral sensitivity:
• Improves insulin cellular signaling.
• Reduces adipose tissue inflammation.
TOTUM-63: a multi-target action on 5 key metabolic organs
Inhibits lipid storage(steatosis reduction).
Preserves insulin secretion capacity.
Acts on intestinal microbiota composition:
• Increased overall richness.
• Positive impact on groups involved in insulin-resistanceand T2D.
Liver
Gut
PancreasMuscle
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 21
TOTUM-63:preclinical data on type 2 diabetes prevention
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 22
Positive and significantresults on:
Fasting glycemiaInsulin-resistanceBody weightFat mass
High Fat Diet mice(HFD)
Diabetic mice model: db/db
Prevention protocols Control (n= 6)HFD (n= 12)HFD + TOTUM-63 (n=11)
Control (n=10)TOTUM-63 (n=10)
TOTUM-63:preclinical data on type 2 diabetes reversion
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 23
Positive and significantresults on:
Glycemia OGTTInsulin-resistanceBody weightFat mass
Reversion protocolsHigh Fat Diet mice (HFD)
Low fat diet, LFD (n= 10)High fat diet, HFD (n= 12)HFD + TOTUM-63 (n= 12)
Feb. 2020 24
TOTUM-63: Phase II clinical results
• Multicenter, randomised, unbalanced (3:1, VALEDIA®:Placebo)and double-blind placebo-controlled study, 2 parallel-groups
• Supplementation period: 6 months, 5 g/day (3 intakes)
• Primary endpoint: change in fasting glycemiabetween baseline and 6 months
• Main secondary endpoints: 2 hours OGTT glycemia, insulinsensitivity, anthropometric parameters, hemodynamicparameters lipid profile, safety
51 prediabetics with abdominal obesity associated with moderatehyperglycemia, hyperglycemia at 2 hours (OGTT) and hypertriglyceridemia.
• Age: 57.1 years• Gender: 35 female, 16 male• BMI: 31.3 kg/m2
• Fasting glycemia: 1.26 g/L• 2 hours OGTT glycemia: 1.85 g/L
• Fasting triglycerides: 1.78 g/L
STUDY DESIGN STUDY POPULATION
è Coordinating Investigator: Dr. David Gendre (MD Biofortis) è Expert: Pr. Jean-Marie Bard (PharmD, PhD, Professor of Basic and Clinical Biochemistry, Nantes, France)è ID-RCB Number: 2016-A00484-47
© NON CONFIDENTIAL - VALBIOTIS
Feb. 2020 25
TOTUM-63: Phase II clinical results
Primary endpoint met: reduction in fasting glycemia vs. placebo
© NON CONFIDENTIAL - VALBIOTIS
– 9.3%a
a Difference of the means of individual variations expressed in %
TOTUM-63
Feb. 2020 26
TOTUM-63: Phase II clinical results
Secondary endpoint met: reduction in 2h-glycemia (OGTT) vs. placebo
© NON CONFIDENTIAL - VALBIOTIS
– 22.5%a TOTUM-63
a Difference of the means of individual variations expressed in %
Feb. 2020 27
TOTUM-63: Phase II clinical results
Secondary endpoints met: reduction in anthropometric parameters vs. placebo
a Difference of the means of individual variations
© NON CONFIDENTIAL - VALBIOTIS
– 1.9 kga– 4.48 cma
TOTUM-63
TOTUM-63: Phase II clinical results
Feb. 2020 28
Secondary criteria endpoints: reduction in triglyceridemia and in Fatty Liver Index vs. placebo
a Difference of the means of individual variations expressed in %
FLI ≥ 60 : High probability of steatosis
© NON CONFIDENTIAL - VALBIOTIS
– 32.2%a – 18.7%a
TOTUM-63
TOTUM-63: Phase II clinical results
Feb. 2020 29
Secondary endpoint met: reduction in systolic blood pressure vs. placebo
a Difference of the means of individual variations
© NON CONFIDENTIAL - VALBIOTIS
– 10.6 mmHga – 18.9 mmHga
Sub-population: subjects with high blood pressureOverall population
Values are expressed as mean ± SEM. *** p<0.001
TOTUM-63
Values are expressed as mean ± SEM. ** p<0.01
Prediabetes market data
Feb. 2020 30
Data: AEC Partners data on key VALBIOTIS markets: the United States, Canada and the 5 primary European countries (Germany, United-Kingdom, France, Spain and Italy ), 2019.
Current average diagnosis rate (US/EU) = 10%
Prediabetic adult population per country (millions)
TOTAL USA, Canada, Top 5 Europe:134 millions person with prediabetes
Today,13.4 millions people diagnosed
with prediabetes, waiting for a solutionmillions diagnosedin the USA10
© NON CONFIDENTIAL - VALBIOTIS
900 million prediabeticsin the world
A fast-growing market in the coming decade: estimate for North America and Top 5 Europe
Feb. 2020 31
1.4
0.6
1.8
1.2
0.80.7
1.0
0.9
1.6
2018 2019 2020 2021 2022 2023 2024 2025 2026 2027
Marketvalue
(billions €)
X3in 10 years
GROWTH LEVERS
• Increasing prevalence of prediabetes
• Continuous progression of screening
• Development of preventionprograms
• Growth of the market of prediabetes healthcare products
Annual growth rate: 12%
Data: AEC Partners data on key VALBIOTIS markets: the United States, Canada and the 5 primary European countries (Germany, United-Kingdom, France, Spain and Italy ), 2019.
© NON CONFIDENTIAL - VALBIOTIS
TOTUM-070,to reduce hypercholesterolemia
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 32
TOTUM-070: an active substance for people with hypercholesterolemia,at risk of cardiovascular diseases
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 33
Mild to moderate elevated blood LDL-cholesterol (“bad cholesterol“),risk factor for cardiovascular diseases
INT E L L E C T U A L P R O P E RT Y
Patent family VALBIOTIS.002(plant extracts / molecules).
VALBIOTIS owns all rights.
Patents registered in 2016,in 24 countries incl. Europe, USA, Canada.Complete characterisation
of the biomolecules(HPLC-UV/MS)
A combinationof alimentaryplant extracts
Hypercholesterolemia:a major component of cardiovascular risk worldwide
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 34
Excessive concentration of "bad" cholesterol (LDL cholesterol) in the blood.Can be associated with an excess of triglycerides or with too low blood "good" cholesterol (HDL cholesterol).
people with hypercholestérolemia in USA and Europe 3. 268 million
Diagnosis criteria: LDL-cholesterol > 1.60 g/L; HDL-cholesterol < 0.40 g/L; total cholesterol > 2.00 g/L.
Checkups are necessary on a regular basis, especially for people with other cardiovascular risk factors.
A frequent metabolic abnormality which affects 39% of the adult world populationand 30% of the French population 1,2.
A major risk factor for atherosclerosis, as obesity, diabetes and high blood pressure,which causes cardiovascular disease: ischemic heart disease, stroke, peripheral arterial disease 2.
1. Global Health Observatory (GHO) data, Organisation Mondiale de la Santé, 2008, www.who.int/gho/ncd/risk_factors/cholesterol_prevalence/en/ ; 2. Ferrières J, Dyslipidémies et risque cardiovasculaire : données épidémiologiques, Endocrinologie et nutrition, 2010.3. Cardiovascular research Group 2011.
TOTUM-448,to reduce non-alcoholic hepatic steatosis
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 35
TOTUM-448: an active substance for people at risk of NASH
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 36
Reduction of non-alcoholic hepatic steatosis (NAFL),risk condition for NASH
Complete characterisationof the biomolecules
(HPLC-UV/MS)
A combinationof alimentaryplant extracts I N T E L L E C T U A L P R O P E RT Y
Patent family VALBIOTIS.001(plant extracts / molecules)
Patents granted in 41 countriesincl. Europe (39 countries) and USA.
Patents under national phase in + 20 countries.
Hepatic steatosis: an opportunity to prevent NASH and its complications
Feb. 2020 37
”The progression from NAFL to NASH dramatically increases the risksof cirrhosis, liver failure, and hepatocellular carcinoma” 1
1. Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis; World Gastroenterology Organization, 2012 ; 2. EASL–EASD–EASO 2016 Clinical Practice Guidelines on the management of non-alcoholic fatty liver disease. J Hepatol 2016
Without intervention, up to 40% of subjects with non-alcoholichepatic steatosis will at least develop NASH within 8 to 13 years. 2
© NON CONFIDENTIAL - VALBIOTIS
Non alcoholic hepatic steatosis,an emerging medical need with specific medical practices
Feb. 2020 38
1. Bedogni, G. et.al., BMC Gastroenterology; 2006 ; 2. EASL–EASD–EASO 2016 Clinical Practice Guidelines on the management of non-alcoholic fatty liver disease. J Hepatol 2016 ; 3. Global Guidelines Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis, World Gastroenterology Organisation, 2012 ; 4. Hernaez R et al. Hepatology. 2011.
Not expensive, largely available,highly sensitive for moderateto severe steatosis. 4
Liver ultrasonography: the recommendednon invasive first line exam for diagnosis 2,3
Fatty Liver Index (FLI):a predictive score for screening in primary care 1
Based on routine clinical examinations:
• Body Mass Index (BMI) and waist size• Blood triglycerides level• Blood Gamma GT (liver enzyme) level
FLI < 30è No steatosis
FLI ≥ 60è High probability of steatosis
Patients with obesity, insulin-resistance,metabolic syndrome, type 2 diabetes.
Recommendations for systematicscreening in at-risk populations 2
© NON CONFIDENTIAL - VALBIOTIS
TOTUM-854,to reduce arterial hypertension
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 39
TOTUM-854: an active substance for people with high blood pressure,at risk of cardiovascular diseases
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 40
Mild to moderate elevated blood pressure,risk factor for cardiovascular diseases
INT E L L E C T U A L P R O P E RT YPatent family VALBIOTIS.001(plant extracts / molecules)
Patents granted in 41 countriesincl. Europe (39 countries) and USA.
Patents under national phases in + 20 countries.
Complete characterisationof the biomolecules
(HPLC-UV/MS)
A combinationof alimentaryplant extracts
Arterial hypertension (AHT):the leading cardiovascular risk factor in the world
Feb. 2020© NON CONFIDENTIAL – VALBIOTIS I 41
Leading chronic disease and cause of premature death worldwide (10 millions deaths in 2015). 1
Causing severe and fatal cardiovascular complications:heart failure, stroke, arterial peripheral diseases, chronic kidney disease, etc. 1
Often combined with other metabolic risk factors: dyslipidemia, glucose intolerance, etc.1
AHT defined as arterial blood pressure ≥ 140/90 mmHg* persisting over time 2,or ≥ 130 /85 mmHg in subjects with metabolic syndrome. 3
people with AHT in the world (2015). 1
Efficient management of AHT decreases the risk of cardiovascular complications and contributes to longer life expectancy. 21 ESC/ESH Guidelines for the management of arterial hypertension, European Heart Journal, 2018 ;2 Prise en charge de l’hypertension artérielle de l’adulte, Recommandation de bonne pratique, HAS, 2016 www.has-sante.fr/jcms/c_2059286/fr/prise-en-charge-de-l-hypertension-arterielle-de-l-adulte ;3 International Diabetes Federation, 2006. Professors Sir George Alberti and Paul Zimmet.The IDF consensus worldwide definition of the METABOLIC SYNDROME* Arterial blood pressure is expressed in mercury millimeters (mmHg)
1.1 billion
Normal arterial blood pressure in adults is established 120 mmHg at heart contraction (systolic pressure)and 80 mmHg at heart relaxation (diastolic pressure). 2
Financial information
Feb. 2020 42© NON CONFIDENTIAL - VALBIOTIS
ALVAL-FR - Shareholders breakdown
Feb. 2020 43
ANALYSTS Portzamparc Christophe DOMBUTarget price: 7,50 EUR (data February 2020)
Invest Securities Thibaut VOGLIMACCI-STEPHANOPOLITarget price: 11,00 EUR (data October 2019)
© NON CONFIDENTIAL - VALBIOTIS
Management
Sofimac Partners
Individuals and institutions
59.3% 15.0%
7.1%
Family offices
18.6%
FREE FLOAT77.9%
Cash and R&D expenses
Feb. 2020 44
Total operating income: € 1,023 K
of which: § Research Tax Credit: € 605 K§ Operating grants: € 372 K
Cash Position : €3.9 millionat 30/06/2019.
Not included:collection of Research Tax Credit 2019 (€ 1.2 M)and gross revenue of Oct. 2019 capital increase (€ 7.2 M) and upfront paiement from Nestlé Health Science (€ 4.7 M).
Total operating income 1,023 1,509
R&D expenses (2,105) (3,826)
Operating and sales expenses (1,464) (2,343)
Current operating income (2,639) (4,876)
Operating income (2,639) (4,876)
Income before tax (2 724) (4,967)
Group net income (2,724) (4,967)
30/06/2019 31/12/2018In € ‘000 - IFRS
© NON CONFIDENTIAL - VALBIOTIS
2020FEB