Dermawhite™ WFThe power of nature to illuminate your skin

1 | The Challenge

2 | The Solution

3 | Efficacy Data

4 | Conclusion

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Market for skin lightening products

0%

10%

20%

30%

40%

50%

60%

70%

80%

Use frequency by women

(United Nations Environment Program, Geneva, 2008)

80 % of all skin-whitening sales within Asia are generated in India.

77 % of all skin-whitening sales within Africa are generated in Nigeria.

“Global Beauty Industry Trends in the 21st Century”, report 2013

The global skin lighteners market is projected to reach US$19.8 billion by 2018, driven by the growing desire for light-colored skin among both men and women primarily from the Asian, African and Middle East regions.

“Companies and Markets”, report 2013

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Need for safe and affordable cosmetic ingredients

Whiteness at a high price

Over-promising products containing

partly questionable ingredients such as-hydroquinone, steroids and mercury compounds.

1 | The Challenge

2 | The Solution

3 | Efficacy Data

4 | Conclusion

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Carica Papaya

Psidium Guajava

Saxifraga Sarmentosa

Dermawhite™ WFThree white flowers for white skin

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Psidium GuajavaPsidium Guajava

• Names:Common guava, yellow guava, lemon guava

• Flower:May bloom and set fruit in as few as 2 years

• Main constituents:Vitamins, tannins, phenolic compounds, flavonoids, essential oils, sesquiterpene alcohols and triterpenoid acids

• Traditional uses: Traditional Chinese medicine Astringency, healing and skin repair Antimicrobial properties Mexico: Leaves are said to be a remedy for itches Amazon, Brazil: A decoction of the bark and/or leaves

or a flower infusion is used topically for wounds, ulcers and skin sores

• Cosmetic science:Excellent tyrosinase inhibitor

In Dermawhite™ WF: Fruit extract

Dermawhite™ WFThree white flowers for white skin

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Carica Papaya Carica Papaya

• Name:Papaya

• Main constituents:Pro-vitamin A carotenoids, vitamin C, folate, lycopene and polyphenols

• Traditional uses: Traditional Chinese medicine Treatment of cuts, rashes, stings and burns Mashed papaya used by the Asian and Pacific

populations to lighten the skin complexion and age spots Cataplasm to cure cutaneous disorders In some parts of Asia, the young leaves of the papaya

are steamed and eaten like spinach• Cosmetic science:

Known tyrosinase inhibitor

In Dermawhite™ WF: Fruit extract

Dermawhite™ WFThree white flowers for white skin

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In Dermawhite™ WF: Extract of entire plant

Saxifraga sarmentosaSaxifraga sarmentosa

• Names:Creeping Rockfoil, Aaron's beard, Mother of Thousands, Roving Sailor, Wandering Jew, Strawberry Begonia, Strawberry Geranium

• Plant:Growing at an altitude of 390–3600 m in China, Russia, Japan and Korea

• Traditional uses: Wound healing Traditional Chinese medicine; treatment of measles,

tympanitis, erysipelas, hemoptysis, piles, and hair fall• Cosmetic science:

Strong tyrosinase inhibitor

Dermawhite™ WFThree white flowers for white skin

1 | The Challenge

2 | The Solution

3 | Efficacy Data

4 | Conclusion

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B16 melanocytes; 72 hrs incubation; measurement of total melanin via optical density at 475 nm

-90%

-25%

Dermawhite™ WFMelanin synthesis (in vitro)

0.001 % DermawhiteTM WF inhibits 90 % melanin synthesis

DermawhiteTM WF is more than 3 times more effective than kojic acid

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Mid to long term clinical studyProtocol

Instrumental evaluationChromameter measurement of L* & ITA° on the face & on the untreated neck control site

Volunteer panel:• 34 Indian women, Phototype IV-V

Test products:• O/W emulsion (Placebo)• O/W emulsion + 2% Dermawhite™ WF

Application:• Double-blind, randomized, split face, twice

daily during 84 days

Placebo creamDermawhite™ WF

at 2%

METHOD

Non-treated control site Reference area to normalize instrumental results independently of variations of skin color due to

external factors during the study period.

Evaluation at D0, D28, D56, D84

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34 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, chromametry

Mid to long term clinical studyResults versus placebo / Chromametry

Whitening efficacy of DermawhiteTM WF is significantly better than placebo

+1,1% vs.D0

+0,2%vs. D0

+21,6% vs.D0

+2,6%vs. D0

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Short to mid term clinical studyProtocol

Instrumental evaluationChromameter measurement of L* & ITA° on the face & on the untreated neck control site

Clinical evaluation:Color evaluation by an expert, scale from 1 to 10 (1=dark skin/10=fair skin)

Evaluation by volunteers: Volunteer self assessment

Volunteer panel:• 32 Indian women, Phototype IV-V

Test products:• O/W emulsion + 2% Kojic Acid (benchmark)• O/W emulsion + 2% Dermawhite™ WF

Application:• Double-blind, randomized, split face, twice

daily during 56 days

Kojic Acid at 2%

Dermawhite™ WF at 2%

METHOD

Non-treated control site Reference area to normalize instrumental results independently of variations of skin color due to

external factors during the study period.

Evaluation at D0, D14, D28, D56

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Chromametry results

32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, chromametry

Short to mid term clinical studyResults versus kojic acid / Chromametry

After 14 days, the whitening efficacy of 2 % of DermawhiteTM WF is significantly better than 2 % kojic acid

+1,8% vs.D0

+0,8%vs. D0

+51,0% vs.D0

+20,9%vs. D0

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32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, dermatological evaluation

Short to mid term clinical studyResults versus kojic acid / Dermatologist

Light skin

Dark skin

34%

25%

12%

2 % of DermawhiteTM WF match the whitening effect of 2 % kojic acid

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32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, volunteers’ self-assessment at day 14

Short to mid term clinical studyVolunteers’ evaluation after 14 days

After 14 days, the effects of 2 % of DermawhiteTM WF are perceived by almost all volunteers and are rated better than 2 % kojic acid

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Before After 56 days

Before After 56days

Improvement Delta

Measured L* 48.2 50.3 2.1

Measured ITA° -4.9 0.9 5.8

Dermatological rating 3 6 100%

Short to mid term clinical studyAverage panelist result

Visible whitening effect of 2 % of DermawhiteTM WF

Example of color change after 56 days

1 | The Challenge

2 | The Solution

3 | Efficacy Data

4 | Summary

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In vitro

In vivo

• DermawhiteTM WF inhibits 90 % melanin synthesis – 3x more effective than kojic acid

• Quantitative measurement - Whitening and luminescence efficacyof DermawhiteTM WF is significantly better than placebo

• Quantitative measurement - After 14 days, the whitening efficacy of 2 % of DermawhiteTM WF is significantly better than 2 % kojicacid

• Clinical evaluation by a dermatologist - 2 % of DermawhiteTM WF matches the whitening effect of 2 % kojic acid

• Self evaluation - After 14 days, the effects of 2 % of DermawhiteTM

WF are perceived by almost all volunteers and are rated better than 2 % kojic acid

Dermawhite™ WFSummary of Tests

Dermawhite™ WFThe power of nature to illuminate your skin

Benefits & Unique Selling Points

Prevents melanin production 3x more effectively than kojic acid Significant whitening and luminescence benefits Clinically proven by a dermatologist to be as effective as kojic acid Panelist satisfaction better than kojic acid

China / Japan Regulations

INCI: Water (and) Tartaric Acid (and) Disodium EDTA (and) Sodium Sulfite (and) Sodium Metabisulfite (and) Glycerin (and) Butylene Glycol (and) SaxifragaSarmentosa Extract (and) Carica Papaya (Papaya) Fruit Extract (and) Psidium Guajava Fruit Extract

Dose of use: 2%

Solubility: water-soluble

Preservatives: none

Product Properties

Body Care

Applications

Face Care

Wipes

Color Care

Formulation InstructionsIncorporate at the end of the formulation at room temperature under gentle stirring. Optimal pH is 6.5-8.5.

PCPC INCI 2007

INCI 2010 Not listed Jap.

Pharma.

IECIC2014

IECIC 2012

IECSC Japan QD additive

X X

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DISCLAIMER

This document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products upon delivery or any other obligation. The claims and supporting data provided in this publication have not been evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and comply with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA, OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERM SAND CONDITIONS OF SALE.

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