MELANOSTATINEtrade5

FOCUSING ON WHITENING

SKIN RADIANCE SKIN LIGHTENING

ndash WHITENING ANTI-DARK SPOT

bull Mechanism of action

bull Antagonist effect of Melanostatinetrade5 on camp

bull Inhibition of Tyrosinase

bull Inhibition hyper-stimulation of melanin

bull Reversing hyper-pigmentation

bull Lightening improvement in Asian skin

bull Cosmetics properties

bull Features and benefits

bull Applications

bull Formulation

Mechanism of action

a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation

Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R

The stimulation of the tyrosinase activity induces the hydroxylation of the amino

acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone

The final step is the synthesis of melanin in organelles called melanosomes in melanocytes

Mechanism of action

Decreases the melanin

synthesis and blocks the

melanin hyper-production

through the inhibition of the

MC1-R

The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity

Antagonist effect of Melanostatinetrade5 on camp

IC50 of Melanostatinetrade5 is 37nM

Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

bull Mechanism of action

bull Antagonist effect of Melanostatinetrade5 on camp

bull Inhibition of Tyrosinase

bull Inhibition hyper-stimulation of melanin

bull Reversing hyper-pigmentation

bull Lightening improvement in Asian skin

bull Cosmetics properties

bull Features and benefits

bull Applications

bull Formulation

Mechanism of action

a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation

Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R

The stimulation of the tyrosinase activity induces the hydroxylation of the amino

acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone

The final step is the synthesis of melanin in organelles called melanosomes in melanocytes

Mechanism of action

Decreases the melanin

synthesis and blocks the

melanin hyper-production

through the inhibition of the

MC1-R

The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity

Antagonist effect of Melanostatinetrade5 on camp

IC50 of Melanostatinetrade5 is 37nM

Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Mechanism of action

a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation

Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R

The stimulation of the tyrosinase activity induces the hydroxylation of the amino

acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone

The final step is the synthesis of melanin in organelles called melanosomes in melanocytes

Mechanism of action

Decreases the melanin

synthesis and blocks the

melanin hyper-production

through the inhibition of the

MC1-R

The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity

Antagonist effect of Melanostatinetrade5 on camp

IC50 of Melanostatinetrade5 is 37nM

Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Mechanism of action

Decreases the melanin

synthesis and blocks the

melanin hyper-production

through the inhibition of the

MC1-R

The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity

Antagonist effect of Melanostatinetrade5 on camp

IC50 of Melanostatinetrade5 is 37nM

Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Antagonist effect of Melanostatinetrade5 on camp

IC50 of Melanostatinetrade5 is 37nM

Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Inhibition of Tyrosinase

The tyrosinase activity is detected with a Western blot

Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody

Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33

Inhibiting hyper-stimulation of melanin

The total proteins content + melanin synthesis

were determined by the colorimetric method

Pierce BCA (Bicinchoninic Acid) Protein Assay

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

α-MSH numerous highly DOPA-

positive melanocytes

α-MSH + MELANOSTATINEtrade5 less

DOPA-positive melanocytes

Reversing hyper-pigmentation

These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated

Melanostatinetrade5 opposes the hyperproduction of melanin

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks

Lightening improvement in Asian skin

With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation

allowing a lighter and luminous skin tone

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

New concept in the inhibition of Melanogenesis Hyper-Stimulation

Decreases a-MSH induced melanin synthesis

Reduces cutaneous hyper pigmentation

Cosmetic Properties

NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER

Features and benefits

Features and benefits

Recommended dosage 4 ndash 8

Potential Applications

Incorporation at the end of the formulation (3540˚C) pH5-7

INCI name Water (and) Dextran (and) Nonapeptide-1

bull Lightening care

bull Whitening

bull Skin tone equalizer

bull Aging spot corrective care

bull Photoaging

bull Ethnic skin care

bull Hand cream

bull Reducing brown spots cream

bull Skin illumination-brilliance (foundation-powder)

Product information

Formulation

Formulation