الرحيم الرحمن الله بسم

Dermatology exam part one

12/2013

1) The skin compartments, dermis& epidermis are:

a. Independent functionally.b. Develop from the same origin.c. Have little anatomical difference.d. Inter dependent functionally.

ANS: D

2) Regarding cell differentiation the following factor affect its sequence:

a. Calcium concentration.b. Protein kinas c.c. Retinoic acid.d. Expression of k1,k10e. Interleukin 1.

ANS: C

3) Profilaggrin:

a. A large calcium binding glycoprotein.b. Expressed in chromosome 1q21.c. High calcium concentration result in its assembly. d. Synthesized in spinous layer.e. Contain 15-20 repetition of filaggrin.

ANS:B

4) Filaggrin:

a. Cationic protein rich in histamine.b. Is a molecule that organizes intermediate filaments into

macromolecules.c. Disappear in the corneal layer.

ANS:B

5) The following cells are mesenchymal in origin:

a. Melanocytes b. Merkls cells.c. Langerhans cells.d. Stem cells. e. Keratinocytes.

ANS: D?

6) periderm:

a. Highly differentiated cells.b. Cells filled with glutamine.c. It eventually shed out into the amniotic fluid as development

proceeds.d. Its cells undergo apoptosis and disappear.

ANS: C

7) Spinous layer:

a. Found in the upper part of epidermis.b. Have round cell nuclei.

c. Completely loses keratin 5 &14d. Have fine and short keratin fibrils.

ANS: B

8) The skin layers in an embryo of 6 weeks:

a. Single layer of periderm.b. Three layers.c. Single layer of germenativum cell.d. Two layers.

ANS:D

9) Which of the following regarding development is correct:

a. Desmosomal protein in 10 week.b. Filaggrin in 12 wks.c. Hair follicles in 15 wks.d. Nail in 25 wks.

ANS:A

10) Which of the following is a component of sebum:

a. Phospholipids b. Glycolipids.c. Squalene.d. Glycoprotein.

ANS:C

11) The antimicrobial effect of the skin can organized by:

a. Specific peptides.b. Phospholipids.c. Glycolipids.d. Pyrolidon.e. Carpoxyurocrnic acid.

ANS:A

12) In the Desmosomal junctions which of the following takes part:

a. Desmoglyins.b. Desmocolins.c. Desmoglyins & Desmocolins only.d. Desmoplakins & desmoglyins.e. Desmoglyins, Desmoplakins & Desmocolins.

ANS:E

13) In tight junction the following molecules are included:

a. Desmoglyins.b. Catinins.c. Claudins & ocludinsd. Connexons.

ANS: C

14) In alopecia areata the following feature is present:

a. Papules.

b. Itchingc. Exclamation mark hair.d. Scales.

ANS: C

15) Regarding formation of corneal envelop:

a. Organized by single compartment.b. Organized by two compartments.c. Purely organized by lipid devoid protein

corneocytes.d. Lipids have no role in envelop formation.e. Organized by 3 compartments.

ANS: D

16) Langerhans cells are:

a. Round in shape.b. Localized in spinous layer.c. Are pigmented cells.d. Have granulated cytoplasm.

ANS: D

17) Regarding pigmentary cells:

a. They travel to epidermis as melanocytes.b. Contain only one pigment.c. Pigments are passed to other cells in

vesicular structure.

d. Pigments are passed to other cells through MELANosmoses

ANS: A? MELANOBLASTS

18) SPRP:

a. Have 5 subtypes.b. Cross link with involucrine.c. Synthesis stimulated with ultraviolet light.d. SPRP3 is much expressed in vivo.e. SPRP 2 is scanty in vivo.

ANS: C

19) Collagen:

a. Is formed of two chains.b. Some are helical others are not.c. Undergoes glycosylation before

expressed procollagen.d. Collagen 4 has staggered appearance.

ANS: C

20) Griseofulvin dosage is:

a. 2 mg /kg /day.b. 100/kg /day.c. 50/kg /day.d. 20/kg /day.e. 10/kg /day

ANS: E

21) The antilepromatous drug that has inflammatory action:

a. Dapsone.b. Rifampecine.c. Corticosteroids.d. Clofazimine.e. Tetracycline.

ANS: A

22) In sever dehydration the following are characteristic features except:

a. Lethargy.b. Sunken eyes.c. Absent tears.d. Eager to drink.e. Depressed anterior fontanel.

ANS: D

23) In addition to water what are important components of ORS (oral rehydration salt) was for rehydration:

a. Bicarbonate & potassium.b. Chloride & potassium.c. Sodium & glucose.d. Sodium & lactate.

ANS: C

24) Neurosyphills:

a. Tabes dorsalis is a feature.b. Appears after 6 month from primary

chancer.c. Are reversible.d. Abscess formation.e. Organism can be isolated from the

lesion.

ANS: A

25) Chancroid has:

a. Clean shallow erosion.b. Deep dirty ulcer.c. Shallow ulcer.d. Discrete enlarged lymph node.

ANS:C

26) Gonorrheal urethritis best treated by:

a. Crystalline penicillin.b. Procaine penicillin. c. Tetracycline.d. Erythromycin.e. Ciprofloxacin.

ANS B

27) The main causative agent of non specific urethritis is:

a. Mycoplasma spp.b. Staphylococcus.c. Streptococcus.

d. Chlamydia trachomatis.e. Niseria gonorrhea.

ANS:D

28) Bullous impetigo is caused by:

a. Streptococcus.b. Staphylococcus.c. Mycobacteriumd. Chlamydia.

ANS:B

29) Pimphigus is skin condition:

a. Caused by microbial infection.b. Malignant formc. Auto immune disease.

ANS:C

30) The following are STD except:

a. Scabies.b. Molloscum contagiosum.c. Syphilis.d. Herpes simplex.e. Gonorrhea.

ANS: B

31) The following are caused by dermatophytes except:

a. Favus.b. Kerion.c. Piedra.d. T.capitis.e. T.corporis

ANS: C

32) Regarding spermatozoa:

a. Are motile in seminiferous tubules.b. Contain 46 chromosomes.c. Contain enzymes in its head aids in

penetrating the ovum.d. Stored in prostate.

ANS: C

33) Regarding dermis:

a. It is unlike epidermis doesn’t undergo sequential differentiation.

b. Structure & organization are not predictable.

c. Structure don’t undergo turnover in normal conditions.

d. Remodeling occur only under pathological process.

ANS: A

34) In Non Hodgkin’s lymphoma the following are true except:

a. Affect the lymph nodes.b. Start in T cells.c. Does not commonly extend to other

tissue.

d. The international WHO classification is the latest classification.

ANS: C

35) The following cause generalized hyper pigmentation:

a. Xeroderma pigmintosa.b. Tattooing.c. Addison’s disease.d. Crohn’s disease.

ANS:C

36) The following is best media to grow Chlamydia:

a. MC MOY cells.b. Treated ……. MC MOY cells.c. Yolk sac of hen.d. Chocolate agar.e. Blood agar.

ANS: A OR B

37) The following is true about gonad tumors’ except:

a. Seminoma is the most common type.b. UN descended testis is prone to be

malignant.c. Seminoma is radio resistant.d. Presence of alfafeto protein.

ANS: A

38) In the stem cell cycle:

a. G1 is greatly variable in duration.b. S phase takes from 4-6 hrs.c. G0 is constant in the cycle.d. G2 takes from 10-12 hrs.

ANS: A

39) In eccrine sweat gland:

a. The secretory part contain 2 layers one clear cell secrete water & electrolyte & other larger of dark cells.

b. The intraepidermal part is known as acrosyringium.

ANS:C

40) Concerning allergic dermatitis in children it start at the age of:

a. 3 days.b. 3 months.c. 3 years.d. 5 years.e. 10 years.

ANS: C 3years in children , 3month in infants

41) Multiple Myeloma all are true except:

a. There is a monoclonal raise in the immunoglobulin electrophoresis.

b. IGA the highest immunoglobulin.c. One of the most aggressive tumors.

ANS: B

42) The following are glycoproteins except:

a. Lamininb. Vitronictin. c. Tinacind. Thrombospondine. Syndican.

ANS: E

43) The following are used in treatment of acne except:

a. Dapsone.b. Retinoic acid.c. Anti androgens.d. Steroids.e. Tetracycline.

ANS: C?

44) The following is true about erector Pilli muscle:

a. Appear from the lateral wall to the hair canal.b. Aids in thermoregulation.c. Contract in high temperature.d. Connected to the basement membrane.

e. Support the sebaceous gland.

ANS: B

45) Apocrine gland:

a. Found in palms & soles.b. The glands secreting milk is one of forms.c. Develop in second month.d. Sweat contains water, glucose & electrolyte.

ANS: B

46) Regarding hair follicle:

a. Villous hair contains medulla.b. Terminal hair grows vertically.c. The order of layer from inside to out side is

(cortex ,medulla ,Huxley ,inner rout & outer rout sheath)

d. The inner rout sheath melanocytes.e. Differentiation & keratinization continue till the end

of hair shaft.

ANS: B

47) Proteoglycan & gags:

a. Have specific core protein in proteoglycans.b. Hold till 2000 of it weight water.c. Are small molecules.d. Consist 2% of the dermal molecules.e. Are present in small amounts in the dermis.

ANS: A

48) Epidermal barrier:

a. Is purely mechanical barrier.b. Soluble substances penetrate easily.c. Water is slightly permeable.d. Highly permeable for covalent substance.

ANS: D

49) Psorriasis is considered as systemic disease the most common system involved with skin:

a. Articular system.b. Respiratory system.c. GITd. Urinary system.e. Nervous system.

ANS: E

50) Best treatment for tinia capitis is:

a. Ketoconazole.b. Topical antifungal.c. Itraconazol.d. Metronidazole.e. Griseofulvin.

ANS: E

51) Which of the following is immune localized to basement membrane:

a. Entacitin.b. Plectin.c. Heparan.d. Collagen 1.e. Collagen 9.

ANS: C

52) Regarding papillary dermis:

a. Contain elunin elastic fibers.b. Have large collagenous fibers.c. Blood capillaries pass in couples to each dermal

papilla.d. e. Transfer cytokines & growth factors to the epidermis.

ANS:E

53) Adherent junctions:

a. Connect neighboring cells.b. Decrease in number with age.c. Density is affected by the body site & sex.d. Is the major type of junction in skin

ANS: A

54) The up words movement of differentiating cells from the basal layer is depend on:

a. Crowding of the newly formed mitotic cells.b. Damage of the desmosomes & hemidesmosome.c. Down regulation of Þ6ß4 integrins.d. Cytokines guard the movement.e. Growth factors controls movement.

ANS: C

55) Subcutaneous tissue:

a. Is absents in & male genitalia.b. Lipocytes develop in the 20th week.c. Some premature as macrophage.d. Adipocytes stores but not produce fats.

ANS: A

56) Brown fats:

a. Mainly found in the retroperitoneal area.b. Produce interleukin 1.c. Are less active than white fat.d. Is mono loculated.e. Have no mitochondria.

ANS: A

57) Dermis:

a. Form 40% of bulk of skin.b. Is completely tensile but restricted pliability.c. Lymphocytes & plasma cells are not found usually in

normal skin.

d. Proteoglycans & gags are the only ground substance.

ANS: D

58) The main lipid component in the corneal envelop is:

a. Phospholipids.b. Cholesterol.c. Ceramides.d. Triglycerides.e. Free fatty acids.

ANS: C

59) In the DEJ which of the following is true:

a. Anchoring filaments connect the LD to the upper dermis.

b. Laminin 5& 6 is the major component of lamina Lucida.

c. d.

ANS: B