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DA dendrite formation
Dendrite guidance
Clock model: axonal and dendritic growth are internally regulated, depending on how to
respond to guidance molecules
WT
Robo3 over-expression in TTMn
Robo3 over-expression in both GF & TTMn
GF, giant fiber interneuronTTMn: tergotrochantral motor neuron
Neuropil model: same guidance molecules for attracting (or including) axon and
dendrite together for synapse
TRENDS in Neurosciences Vol.27 No.4 April 2004
achaete scute
atonal
amos
Proneural genesSensory organs
+ + associated associated
MD MD neuronsneurons
+ + associated associated
MD MD neuronsneurons
solo-MD solo-MD neuronsneurons
ES MD / mono-ES MD / poly-ES
CH MD / CH solo-MD
ASC ASCASC
ato ato amos
Brewster and Bodmer, 1995
ES
CH
MDamos
Control of dendrite developmentControl of dendrite development
Luo. et al. Trends Neuroscience (2003)
DA Dendrite formation
Constitutive active CDC42 induce supernumerary primary dendrites that fail to extend dorsally and grow secondary dendrites
WT
CDC42
pros mutations causes routing defect
Lateral branch defects: (A) WT, (B) reduced, (C) fail to extend, (E, F) over shrinking
Increased density
Sequotia (水杉 ), Zn finger protein
No repulsion in dorsal groupNo invasion into ablated region in dorsal region in third instar
Competition between two dorsal groups of contralateral dorsal groups
Dorsal dendrite overextension in flamingo mutants
Class I Class II
Class III
Development (2002) Grueber et al
Tiling of dendrites within the same class of DA neuronsTiling of dendrites within the same class of DA neurons
Cell (2003) Grueber et al
Dendrites of different classes overlap extensively
Class III and IVClass I and IV
Class IV tiling
Differential Cut levels in four types of DA neurons
cut mutant phenotypes in class III
Class II
Class I
Class I
Class II
Class IV
No effect on class III
Dendrites over-branching and over-lapping phenotypes
Defect in like-dendrite avoidance response
WT
fry
Heteroneuronal tiling defect
Trc kinase
Rac
Fry
branching
tiling
