College of Pharmacy - University of Minnesota | - … · Web viewOver the years, I have presented keynote addresses at prominent institutions throughout US, other parts of North American,

Curriculum Vitae

John Michael Pezzuto

Biographical Sketch: Dr. Pezzuto received his A.B. degree in chemistry from Rutgers University (1973) and Ph.D. in biochemistry from the University of Medicine and Dentistry of New Jersey (1977). He then performed two years of postdoctoral work in the Department of Chemistry at Massachusetts Institute of Technology, where he was the recipient of a postdoctoral fellowship from the National Cancer Institute. Following a one-year stay at the University of Virginia, as Instructor of Chemistry, he accepted a faculty position (Assistant Professor) at the University of Illinois at Chicago (1980). He was promoted to the rank of Associate Professor in 1984, and to full professor in both the College of Pharmacy (1991-2002) and the College of Medicine (1994-2002) at the University of Illinois at Chicago. He was named Distinguished University Professor in 2002. He served as Head (1993-1995) and Interim Head (2000-2001) of the Department of Medicinal Chemistry and Pharmacognosy at the UIC College of Pharmacy, Associate Director of the UIC Cancer Center (1991-1995), and Director of the Program for Collaborative Research in the Pharmaceutical Sciences (1995-1998), the leading research unit affiliated with the UIC College of Pharmacy. He later served as Associate Dean for Research and Graduate Education, UIC College of Pharmacy (1998-2002), Deputy Director of the UIC Cancer Center (2000-2002), and Head of the Department of Medicinal Chemistry and Pharmacognosy (2001-2002). In 2002, Dr. Pezzuto accepted the position of Professor of Medicinal Chemistry and Molecular Pharmacology, and Dean of the College of Pharmacy, Nursing and Health Sciences, at Purdue University, West Lafayette, Indiana (2002-2006). He also served as Chief Scientific Officer for pharmaceutical development at McClure Park, Inc., an affiliate of the Purdue Research Foundation (2004-2006). In 2006, Dr. Pezzuto became the Founding Dean of the Daniel K. Inouye College of Pharmacy at the University of Hawaii at Hilo. Over the period of nine years, the College was built from the ground up, now holding a respectable position in academic pharmacy. He is currently Professor and Dean of the Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, and holds adjunct professorial positions at the University of Illinois at Chicago, Purdue University, and the University of Hawaii. He is an author of over 500 publications, co-inventor of several patents, the editor of four books, member of over 10 editorial boards of international journals, the former editor-in-chief of the International Journal of Pharmacognosy (1990-1995), the former editor-in-chief of Combinatorial Chemistry and High Throughput Screening (1996-1997), and the current editor-in-chief of Pharmaceutical Biology. He served as a full member of Subcommittee E (cancer epidemiology, prevention and control) of the National Cancer Institute (2003-2007). He was the recipient of a Research Career Development Award from the National Cancer Institute (1984-1989) and a Research Fellowship from the Alexander von Humboldt Foundation (1990-1991). During the period of the Humboldt fellowship, he held a research position in the Department of Pharmaceutical Biology at the University of Munich. He has directed the research of numerous doctoral students, postdoctoral associates, and visiting scholars. He was elected Senior University Scholar at UIC in 1999, UIC Inventor of the Year in 2000, Fellow of the American Association for the Advancement of Science in 2012, and recipient of the Volwiler Research Award by the American Association of Colleges of Pharmacy in 2014. His current research interests are predominately in the areas of biology-driven natural product drug discovery and characterization, with primary emphasis in the fields of cancer chemotherapy and cancer chemoprevention. He received financial support by the National Institutes of Health for over 35 years, and currently directs a long-term project designed to investigate the effect of grape consumption on health and longevity. He resides in Brookville, NY, with his wife and three children.

ContentsCurriculum Vitae...................................................................................................................................................1

PERSONAL DATA........................................................................................................................1ACADEMIC/PROFESSIONAL POSITIONS.................................................................................1EDUCATION.................................................................................................................................4AWARDS AND HONORS.............................................................................................................4RESEARCH INTERESTS.............................................................................................................6TEACHING EXPERIENCE (EXAMPLES)....................................................................................7ADMINISTRATIVE RESPONSIBILITIES/EXPERIENCE.............................................................8COMMITTEES (EXAMPLES).....................................................................................................10THESES COMMITTEES.............................................................................................................12GRANT AND MANUSCRIPT REVIEWS (PARTIAL LISTING)..................................................13MISCELLANEOUS EXTERNAL REVIEWS...............................................................................20EDITORIAL POSITIONS.............................................................................................................21LISTING IN REFERENCE SOURCES........................................................................................22PATENTS/DISCLOSURES.........................................................................................................22LICENSING AGREEMENTS.......................................................................................................24DRUG DEVELOPMENT APPLICATIONS..................................................................................24CONSULTING/ADVISORY GROUPS........................................................................................24EXAMPLES OF PUBLIC SERVICE/RELATIONS/COMMUNICATIONS...................................26PURDUE UNIVERSITY COLLEGE OF PHARMACY, NURSING, AND HEALTH SCIENCES ACTIVITIES.................................................................................................................................30

School activities:.......................................................................................................................30School publications:.................................................................................................................30University memberships:..........................................................................................................30Other memberships:.................................................................................................................31Teaching:..................................................................................................................................31

UNIVERSITY OF HAWAII AT HILO, COLLEGE OF PHARMACY ACTIVITIES.......................31SUPERVISION OF RESEARCH PERSONNEL.........................................................................32EXTRAMURAL FUNDING..........................................................................................................35

Funded (Previous)....................................................................................................................35Funded (Currently Active at LIU)..............................................................................................40Funding (Submitted/in Preparation).........................................................................................40Master Agreements..................................................................................................................41Gifts Provided to Support Research Initiatives.........................................................................41Intramural Funding...................................................................................................................41

PUBLICATIONS..........................................................................................................................42Ph.D. Dissertation....................................................................................................................42Articles in print/in press............................................................................................................42Articles Submitted/Actively In Preparation...............................................................................82Book Chapters..........................................................................................................................83Book Reviews...........................................................................................................................87Miscellaneous Editorial Contributions......................................................................................88Books/Proceedings Edited.......................................................................................................89

Published Abstracts and Papers Presented.............................................................................89

MEETINGS OR SYMPOSIA CHAIRED/ORGANIZED; WORKSHOPS CONDUCTED...........138COMPLETE WORKS REPRINTED OR ABSTRACTED IN SECONDARY SOURCES..........140

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Personal Data

Name: John Michael Pezzuto

Home Address: 22 Norgate RoadBrookville, NY 11548

Mailing Address: Arnold & Marie Schwartz College of Pharmacy and Health SciencesLong Island University75 DeKalb Ave.Brooklyn, NY 11201

Communications: (808) 960-1698 (Cell)(718) 488-1004 (Business)(718) 488-0628 (Fax)[email protected] (E-mail)

Birth: August 29, 1950 [to Michael L. Pezzuto and Elizabeth Brown (Pezzuto)]

Place of Birth: Hammonton, New Jersey

Nationality: U.S. Citizen

Family Status: Married [Mimi Faith Rotstein (Pezzuto), R.Ph.], three children (John-Henry Albert, born 5 September 1993; Elisabeth Lee, born 23 August 2000; Michael Joseph Ivan, born 14 January 2002).

Academic/Professional Positions

1973-1977 Teaching Assistant, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey

1977-1979 Postdoctoral Associate, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts (NIH Postdoctoral Trainee, 1977-1978; NIH Postdoctoral Fellow, 1978-1979)

1979-1980 Instructor of Chemistry, Department of Chemistry, University of Virginia, Charlottesville, Virginia (NIH Postdoctoral Fellow)

1980-1983 Assistant Professor, Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois (the department was re-organized in 1983)

1981-2002 Member, Graduate College, University of Illinois at Chicago, Chicago, Illinois

1983-2002 Member, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1983-1984 Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1984-1989 National Institutes of Health Research Career Development Awardee

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1984-1991 Associate Professor, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1985-1992 Associate Professor, Department of Surgery, Division of Surgical Oncology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois

1987-1991 Member, Specialized Center for Cancer Research and Education, College of Medicine, University of Illinois at Chicago, Chicago, Illinois

1989-1991 Attending Member, Scientific Staff, Department of Surgery, Michael Reese Hospital and Medical Center, Chicago, Illinois

1990-1991 Research Fellow, Alexander von Humboldt Foundation, Federal Republic of Germany

1990-1991 Visiting Scientist, Institute for Pharmaceutical Biology, University of Munich, Munich, Federal Republic of Germany

1991-1994 Program Leader, Pharmacology and Developmental Therapeutics, Specialized Cancer Center, University of Illinois at Chicago, Chicago, Illinois

1991-2002 Professor, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1991-2002 Director, Bioassay Research Facility, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1991-1995 Associate Director, Specialized Cancer Center, College of Medicine, University of Illinois at Chicago, Chicago, Illinois

1991-1996 Editor-in-Chief, International Journal of Pharmacognosy, Swets & Zeitlinger Publishers.

1992-1995 Interim Head, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1992-1995 Director, Graduate Program in Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois

1992-2002 Professor, Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois

1995-1998 Director, Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois

1996-1997 Director (pro tempore), Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

1996-1998 Associate Editor, International Journal of Pharmacognosy, Swets & Zeitlinger Publishers.

1996-1997 Editor-in-Chief, Combinatorial Chemistry and High Throughput Screening, Bentham Science Publishers.

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1996-2002 Program Leader, Cancer Chemoprevention, University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois

1997-present Editor-in-Chief, Pharmaceutical Biology, Informa Healthcare, publishers.

1998-2002 Associate Dean for Research and Graduate Education, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

2002 Deputy Director, University of Illinois Cancer Center, Chicago, Illinois.

2000-2001 Interim Head, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

2002 Head, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois

2002 Distinguished University Professor, University of Illinois at Chicago, Chicago, Illinois

2002-present Adjunct Professor, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois

2002-2006 Professor, Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana

2002-2006 Dean, College of Pharmacy, Nursing and Health Sciences, Purdue University, West Lafayette, Indiana

2004-2006 Chief Scientific Officer for Pharmaceutical Development, McClure Park Inc., West Lafayette, Indiana

2006-present Adjunct Professor, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana

2006-2009 Professor, Department of Chemistry, College of Liberal Arts and Science, University of Hawaii at Hilo, Hilo, Hawaii

2009-2015 Professor, Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii

2006-2015 Professor and Founding Dean, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo Hawaii (designated Dean Emeritus)

2010-2015 Adjunct Professor, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa

2015-present Professor and Dean, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY

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Education

1973 Rutgers University, Camden, N.J.

Degree of Bachelor of Arts majoring in chemistry. Minor in mathematics; some supplementary work was done concerning theoretical wave equations.

1977 University of Medicine and Dentistry of New Jersey - New Jersey Medical School, Newark, N.J. (now Rutgers University)

Degree of Doctor of Philosophy. Graduate Student Association (departmental representative); several committee positions; Teaching Assistantship.

Awards and Honors

Over the years, I have presented keynote addresses at prominent institutions throughout US, other parts of North American, South America, Asia, and Europe. My work on resveratrol has been cited over 3,000-times and has inspired approximately 15,000 papers in the field. My h-index is over 60. In addition to basic research, however, I have strongly advocated for the profession of pharmacy. I have presented keynote addresses at venues such as the APhA, Hawaii Pharmacists Association, Rho Chi inductions, White Coat ceremonies, and many more. I have supported and fostered the development of clinical pharmacy programs in Indianapolis while at Purdue and neighbor islands including Oahu while at UH Hilo. I have supported preceptors, residents, and innovative approaches for pharmacy education. I have served on the Hilo Medical Center Foundation and I have been recognized by the community for contributing to improvements in health care. At Hawaii, a $14 M award was received from CMS to promote the role of the pharmacist in healthcare transitions from hospitals to the community. A $16 M dollar award was received to create a Beacon Community. Some honors and awards are listed below.

NIH Postdoctoral Trainee and Fellow, 1977-1980.

NIH Research Career Development Awardee, 1984-1989.

Research Fellow, Alexander von Humboldt Foundation, 1990-1991.

Presented lecture entitled “Discovery of Betulinic Acid as a Selective Inhibitor of Human Melanoma that Functions by Induction of Apoptosis” at the first "Late-breaking Research Session" of the 86th Annual Meeting of the American Association for Cancer Research, Toronto, Canada, March 1995.

Presented keynote lecture entitled “Natural Product Chemopreventive Agents” at the 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytother-apy, Munich, Germany, September 1996.

Editor-in-Chief, Pharmaceutical Biology, 1997-present.

Presented keynote lecture entitled “Natural Products: The Backbone of Novel Drug Discovery” at the 24th Annual MALTO meeting, University of Arkansas, Little Rock, Arkansas, May 1997 (invited participant in a special symposium entitled "Frontiers in Pharmaceutical Research and Their Impact on Graduate Education").

Presented lecture entitled “Discovery and Characterization of Natural Product Cancer

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Chemopreventive and Chemotherapeutic Agents” at the 3rd Cycle in Pharmaceutical Sciences, Search for New Lead Compounds and in Particular Anticancer and Antiviral Agents of Natural Origin, Zermatt, Switzerland, October 1997.

Presented lecture entitled “Breakthroughs in Natural Product Drug Discovery at UIC” at the UIC Corporate and Foundation Donor Recognition Luncheon, Chicago, IL, March 1998.

Presented inaugural address entitled “Bioassay-Driven Natural Product Drug Discovery,” Department of Biology, Yildiz Technical University, Istanbul, Turkey, May 1998.

Presented inaugural address entitled “Development of Bioassay Systems Necessary for the Discovery of Natural Product Drugs,” Research and Development Centre for Applied Chem-istry, Indonesian Institute of Sciences, Bandung, Indonesia, June 1998.

Elected Senior University Scholar, University of Illinois at Chicago, 1999.

Presented the Varian Lectures in Chemistry and Biology, entitled "Natural Inhibitors of Carcinogenesis" and "In Vitro Models of Human Disease States," University of Ottawa Department of Chemistry, February 2000.

Presented keynote address entitled "Cancer Chemoprevention, Great Hope for the New Millenium" at the XXI Research Forum of the Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, April 2000.

Elected University of Illinois at Chicago Inventor of the Year, 2000.

Listed in ISIHighlyCited.com (Current Contents) as one of the most highly cited publishing researchers (includes less than 0.5% of researchers), 2002.

Appointed Distinguished University Professor, University of Illinois at Chicago, 2002.

Received Distinguished Alumnus Award, University of Medicine & Dentistry of New Jer-sey, May 2003.

Received award acknowledging greatest contribution to community health in 2010, Rotary Club of South Hilo, October 2010.

Invited to present the “7th Annual Medicines from Nature Lecture”, University of Arkansas for Medical Sciences, Little Rock, Arkansas, Dec. 2, 2012.

Elected Fellow of the American Association for the Advancement of Science (AAAS), 2012.

Received recognition as ‘Friend of Pharmacy’ during the 2013 annual meeting of the Hawaii Pharmacists Association, 2013.

Selected as recipient of the Volwiler Research Award by the American Association of Colleges of Pharmacy, 2014.

Selected by the Cantine Due Palme to be honored with its “Premio Speciale Cantine Due Palme” award. The award is presented by the winery to “eminent personalities who made outstanding contributions in the field of research and culture.” Award presented at a ceremony on May 9, 2014, in the exclusive Selvarossa Conference Room, located in Puglia, Italy.

Selected to present the Ohdang Plenary Lecture of 2014, Fall Annual Convention of the

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Pharmaceutical Society of Korea, Gyeongjy, Korea, October 2014.

Presented keynote commencement address at the 2015 Graduation Commencement of the University of Hawaii at Hilo (received Chancellor’s Award for Excellence).

Research Interests

1973-1975 Prior to beginning work for the Ph.D. dissertation, experimental efforts included: examination of riboflavin deficiency in alcohol fed mice; development of a novel paper chromatography system to remove weakly bound xenobiotics from strongly bound DNA complexes; examination of the mechanism of action of cyanate (a potential carcinostatic agent) by comparison of normal rat liver with several hepatomas which were carried subcutaneously; isolation and characterization bacterial DNA with an extremely high guanosine content; organic synthesis of an active carcinogen metabolite; measurement of the binding half-life of a metabolically activated carcinogen to isolated DNA. Experimental studies were supported by an Institutional Research Fellowship during the summer of 1974.

1975-1977 University of Medicine and Dentistry of New Jersey - New Jersey Medical School, Newark, New Jersey

Dissertation work primarily explored chemical carcinogenesis at the molecular level. For the first time, it was found that the envelope of the cell nucleus contains enzymes capable of activating benzo(a)pyrene to ultimate carcinogenic species that covalently bind to intranuclear components. Some of the experiments were performed at the National Cancer Institute in the laboratory of Dr. H.V. Gelboin.

1977-1979 Massachusetts Institute of Technology, Cambridge, Massachusetts

Projects related primarily to general aspects of molecular biology. These included studies to define the structure and function of tRNA, mechanisms of enzyme catalysis, and several aspects of protein biosynthesis. Additionally, in collaboration with members of the MIT Genetic Toxicology Group, the mechanisms facilitated by potent naturally occurring mutagens were examined.

1979-1980 University of Virginia, Charlottesville, Virginia

Several novel techniques were combined allowing the introduction of amino acid substitutes into predetermined positions of proteins produced by in vitro model systems. These studies helped to elucidate protein structure and function, as well as the molecular events related to protein biosynthesis. Additional work dealt with the synthesis of tRNA dimers for use in studies to examine the processing of tRNA precursor molecules.

1990-1991 University of Munich, Munich, Germany

Studies were conducted to evaluate the potential of antitumor agents to mediate immunomodulatory responses in extremely low concentrations, and to investigate the mechanism of active agents. In addition, the ability of various agents to induce the expression of lymphokines was investigated.

1980-2002 University of Illinois at Chicago, Chicago, Illinois

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Research interests included: molecular mechanisms of mutagenesis; natural products as inhibitors of chemical carcinogenesis; biological evaluation of potential cancer chemotherapeutic agents; biospecific isolation of chemotherapeutic agents from plant materials; isolation and characterization of anti-HIV and antimalarial agents; evaluation of test agents for cancer preventative and therapeutic activity employing animal models; characterization of dietary supplements with special emphasis on women’s health issues.

2002-2006 Purdue University, West Lafayette, Indiana

Research interests included: natural products as inhibitors of chemical carcinogenesis; biological evaluation of potential cancer chemotherapeutic agents; biospecific isolation of chemotherapeutic agents from plant materials; evaluation of test agents for cancer preventative and therapeutic activity employing animal models.

2006-2015 University of Hawaii at Hilo, Hilo, Hawaii

Current research interests include: natural products as inhibitors of chemical carcinogenesis; biological evaluation of potential cancer chemotherapeutic agents; biospecific isolation of chemotherapeutic agents from plant materials; evaluation of test agents for cancer preventative and therapeutic activity employing animal models.

2015-present Long Island University, Brooklyn, New York

Work continues in studying natural product drugs with emphasis in cancer therapy and prevention. A major project involves investigation of the potential health benefits of long-term grape consumption.

Teaching Experience (examples)

Undergraduate:

Biological Chemistry (laboratory and didactic), 1979-1980, University of Virginia.Medicinal Chemistry/Pharmacognosy (laboratory and didactic), 1980-present.Drug Bioscreening (laboratory and didactic), 1982.Mechanisms of Drug and Chemical Toxicity, 1982-1987.Biology 514, Toxicology, "Carcinogenesis and Genetic Toxicology," 1982, 1985, 1988,

1989, Illinois Institute of Technology.Undergraduate Research Courses (Independent Study), 1981, 1983, 1984, 1986, 1987-

1990, 1992-2002.Coordinator and manager of “The Dean’s Executive Forum” (one credit elective for

Pharm.D. students).

Graduate:

Research Techniques, 1980-present (Coordinator, 1983-1984).Advanced Natural Products I, 1980-2002.Advanced Natural Products II, 1980-2002.Graduate Research Courses, 1980-2002.Departmental Seminar (Coordinator), 1981-82, 1983-84, 1989-90, 1994-95."Methods of Evaluating Biologically-Active Natural Products" (PMPG 480), 1992, 1994,

1996 (Design, implementation and coordination of a new core course).

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Administrative Responsibilities/Experience

As Department Head: Management of a department comprised of approximately 120 individuals (22 faculty with an annual budget of ~$6,300,000); supervision and coordination of office clerical staff (six members); head of graduate program in medicinal chemistry; responsible for department curriculum and institution of new initiatives such as biotechnology in the professional curriculum; chair of department advisory committee and faculty meetings; initiated searches and completed negotiations for hiring five new faculty within the department; lines reporting to the department head include the director of curricular affairs, the assistant department head, the director of graduate studies, and the director of the program for collaborative research in the pharmaceutical sciences; responsible for intra-departmental remodeling projects (~$1,500,000); interaction with community centers in the greater Chicago area (e.g., donation of a 60 MHz NMR to the Departments of Chemistry and Physics at Lane Technical High School in Chicago); involved in the resolution of all legal matters affecting the department; responsible for faculty development, salaries, and promotions; responsible for safety and hygienic issues affecting the department. During the tenure of Dr. Pezzuto as Department Head, the department achieved a ranking of 5th in terms of research support (there are a total of ~170 departments). (N.B. Dr. Pezzuto served as Head or Interim Head during the periods of 1992-1995, and 2000-2002).

As Associate Director, UIC Cancer Center: Assisted Director in preparing reports, handling site visits and presentations, coordinated research activities; aided in the continuation of training grants awarded by the NCI and Army; attended Executive Committee meetings and implemented action points; served as liaison with External and Internal Advisory Committees; coordinated the efforts of the Experimental Therapeutics group (Group Leader) (effective July 1994, the Cancer Center was converted to the Department of Surgical Oncology, University of Illinois College of Medicine; Dr. Pezzuto held the rank of full professor in this department).

As Director, Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), UIC: Dr. Pezzuto was the chief administrative officer of the PCRPS. This is the premier research unit affiliated with the College of Pharmacy. It houses the graduate program in natural products research (approximately 30 students), and the research efforts of ~75 individuals. Funding typically comprises ~60% of the College's extramural support, and ranks within the top 10 of the entire campus. The Program fosters multidisciplinary and collaborative research, as exemplified by a funded program project grant (J.M. Pezzuto, Program Director), a funded National Collaborative Drug Discovery Group, and a funded International Collaborative Biodiversity Group.

As Associate Dean for Research and Graduate Education, UIC College of Pharmacy: Advised the Dean and represented the College of Pharmacy on matters of research and graduate education; served as director of the umbrella Ph.D. program in pharmacy operated in the College of Pharmacy (1998-2000); oversaw operation of research units within the College (Directors report to the Associate Dean); fostered collaborative and individual research; promoted the mission of graduate education; chaired ad hoc committees related to research and graduate education policies and initiatives; served as CEO in the absence of the Dean. During the tenure of Dr. Pezzuto in this position, in terms of research support, the College of Pharmacy ranked first among all Big Ten Colleges of Pharmacy, and second among all U.S. Colleges of Pharmacy.

As Deputy Director of the University of Illinois Cancer Center, University of Illinois at Chicago: in conjunction with the Director, Dr. Pezzuto was responsible for the overall establishment and management of the Cancer Center. Scientific Program Leaders report to the Deputy Director.

As Dean of College of Pharmacy, Nursing and Health Sciences, Purdue University. Dr.

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Pezzuto reported to the Provost, with frequent interactions with the President of Purdue University. Overall academic and fudicial responsibility resides in the Office of the Dean. Some recent accomplishments include establishment of a new cGMP facility, creation of a formal partnership with Wishard Hospital in Indianapolis, revision of a BS in the pharmaceutical sciences program, establishment of a new MS program in nursing and a new PharmD/MBA program in collaboration with the Krannert School of Management, enhancements in multicultural activities, establishment of an endowed chair in pharmacy, and a near completion of a $30 million capital campaign. The School of Pharmacy has been ranked second nationally. The Dean managed a course in the professional curriculum referred to as the Dean’s Forum, chaired the Executive Committee and faculty meetings, participated in fund raising, professional relations, numerous campus and school committees, recruiting and start-up, chairs advisory council meetings, etc. The Schools are comprised of approximately 120 tenure track faculty and have a student enrollment of approximately 2,700. The annual budget is approximately $50 million.

As Founding Dean of the new College of Pharmacy at the University of Hawaii at Hilo. In 2006, Dr. Pezzuto accepted the position of Professor and Founding Dean, College of Pharmacy, University of Hawaii. This is the only College of Pharmacy in the State of Hawaii and the entire Pacific Basin. Placement in Hilo was designed to broaden the scope to a point of enhancing science throughout the campus. Prepharmacy programs were established on the main campus. Library resources were enhanced so that now the best pharmacy library in the State is based on the Hilo campus. For creation of the College of Pharmacy, the organizational structure was established and approved by the UH Board of Regents (BOR). Next, the curriculum was designed and degree-granting authority was provided by the BOR. Successful applications for accreditation were reviewed through site visits conducted by the Western Association of Schools and Colleges (WASC) and the Accreditation Council of Pharmaceutical Education (ACPE). The first group of administrators, faculty and staff were successfully recruited and relocated. Recruitment continued until reaching a goal of about 75 faculty, staff, and administrators. The first class of 90 students were interviewed and accepted, instruction started in August 2007, and 84 graduated with a Doctor of Pharmacy (PharmD) from a fully accredited college in May 2011. Currently, about 350 students are enrolled. Over 250 clinical affiliation agreements have been established on the Island of Hawaii, throughout the state, on the mainland, and throughout the Pacific Region and Alaska. Construction of the first interim facility (approximately $12 M) was completed. Planning and design of a permanent facility was completed and about $35 M was secured for construction. The Dean is ultimately responsible for all aspects of creating and managing this College. New degree programs were instituted with BOR and WASC approval (BA in Pharmacy Studies, PhD in Pharmaceutical Science, MS in Clinical Psychopharmacology). A pharmacy residency program was launched on Maui and fully accredited by ASHP. The College is projected to stimulate more than $50 million per year in economic activity in the State and was awarded more than $16 million in federal funds to become the administrative center of a federally funded Beacon Community as well as a $14 million award from CMS to explore a pharmacist-based health transition model at the time patients are discharged from hospitals. The College is research intensive with the goal excelling in ranking in due course.

As Dean of the Arnold & Marie Schwartz College of Pharmacy and Health Sciences, emphasis has been placed on re-vitalization. Over the course of a year, the following has been accomplished. Chronic issues related to professional accreditation were resolved and the College is now fully accredited until 2022. Committee structures have been revamped, the administrative structure has been revised, extramural support increased by approximately $4.0 M, numerous grant applications have been submitted, the collective bargaining agreement has been completely restructured, international experiential rotation sites have be established, the first college-based residency program was established and two residents have be recruited, a new student lounge has been opened, new faculty members and directors and an Associate

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Dean have been recruited, facility improvements such as lecture capture have been realized, new curriculum has been implemented, and private funding was obtained to build a sterility testing laboratory. Work is ongoing but overall there is a new spirit of empowerment and vigor.

Committees (examples)

Member, Executive Committee, College of Pharmacy, 1981-1983.Member, Department Committee on Graduate Education, 1981-1984.Member, Search Committee for Assistant Professor of Pharmacology, College of

Pharmacy, 1981.Member, ad hoc Committee to Generate Curricular Proposals, 1982.Member, Search Committee for Assistant Professor of Medicine, College of Medicine,

Section of Medical Oncology, 1982, 1983 (two positions).Member, Search Committee for Assistant Professor of Medicine, College of Medicine,

Section of Gastroenterology, 1983.Member, ad hoc Committee to Elect Department Advisory Committee, 1983.Member, ad hoc Committee to Develop Course Outlines in Medicinal Chemistry and

Pharmacognosy I and II, 1983.Member, ad hoc Committee to Develop Course Outlines in Medicinal Chemistry and

Pharmacognosy III, IV and V, 1983.Member, ad hoc Committee to Develop Course Outlines in Antibiotics and Antineoplastics,

1983.Member, Academic Standing Committee, College of Pharmacy, 1983-1985.Member (pro tempore), Task Force on Graduate Education, 1983.Member, Department of Medicinal Chemistry and Pharmacognosy Advisory Committee,

1983-1986, 1988-1992, 1995-1997, 1997-1999 (elected).Member, Search Committee for Assistant Professor of Pharmacognosy, College of

Pharmacy, 1984.Member, Webster-Sibilsky Lectureship Committee, College of Pharmacy, 1984.Chairman, Committee for Research, PCRPS, College of Pharmacy, 1984-1987.Member, ad hoc Committee to Evaluate Computer Utilization, College of Pharmacy, 1985-

1986.Member, Biohazards Discussion Group, Office of the Vice Chancellor for Research, UIC,

1986.Member, Search Committee for Assistant Professor of Medicinal Chemistry, College of

Pharmacy, 1986.Member, Institutional Biosafety Committee, Office of the Vice Chancellor for Research,

UIC, 1987-1992.Member, BRSG Review Committee, College of Pharmacy, 1987-1989.Chairman, Biotechnology Implementation Committee, College of Pharmacy, 1988-1989.Member, Search Committee for Assistant Professors of Medicinal Chemistry and

Pharmacognosy (3 positions), College of Pharmacy, 1989.Member, Planning Committee for the development of a Center of Pharmaceutical

Biotechnology within the College of Pharmacy, 1989-1990.Member, Senate Committee on External Relations, Subcommittee on Honorary Degrees,

UIC, 1990.Member, Resolutions Committee, American Society of Pharmacognosy, 1990-1995.Member, ad hoc Committee on College of Pharmacy Monthly Seminar Program, College

of Pharmacy, 1991-1993.Member, Search Committees for Assistant Professors of Biotechnology, College of

Pharmacy, 1992, 1993.Member, Search Committee for Vice Dean of Academic Affairs, College of Pharmacy,

1992.

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Chair, Committee to Evaluate Grants and Salary Support, College of Pharmacy, 1994.Member, Search Committee for a Vice Chancellor for Research and Dean of the Graduate

College, UIC, 1994-1995.Member, Search Committee for Director of the Office for Development, College of

Pharmacy, UIC, 1994.Member, Advisory Committee for the Research Resources Center of the UIC, 1994-1995.Member, Basic Life Sciences subcommittee of the Campus Research Board, Office of the

Vice Chancellor for Research, UIC, 1995-1998.Member, Search Committee for faculty members of the UIC College of Medicine Cancer

Center, 1996-1997.Member, Committee to Address College and Department Issues Concerning Salary

Savings on Grants and Awards, UIC College of Pharmacy, 1996.Member, Strategic Planning Council, UIC College of Pharmacy, 1996-1997.Member, Search Committee for Associate Vice Chancellor for Research, UIC, 1996-1997.Member, Flow Cytometry Advisory Subcommittee, Research Resources Center, UIC,

1997-2002.Chair, Search Committee for faculty positions, Department of Medicinal Chemistry and

Pharmacognosy, UIC, 1997.Chair, Committee to organize faculty retreat to study graduate education, College of

Pharmacy, UIC, 1997.Member, Scientific Advisory Board, UIC Cancer Center, 1997-1999.Member, Inquiry Team for the Investigation of Scientific Misconduct, Office of the Vice

Chancellor for Research, UIC, 1997.Member, Task Force on College Infrastructure, UIC College of Pharmacy, 1997.Member, Inquiry Team for the Investigation of Scientific Misconduct, Office of Dean,

College Pharmacy, UIC, 1997.Member, Executive Committee, Graduate College, UIC, 1997-1999 (appointed).Parliamentarian, Faculty of the UIC College of Pharmacy, 1997-present (elected).Chair, Committee for Evaluation of Mid-term Promotion and Tenure Dossiers, Department

of Medicinal Chemistry and Pharmacognosy, UIC, 1998.Member, Prevention Working Group of the American Association for Cancer Research,

1998-2000.Member, Planning Committee for the Consortium on Human Health and Soybeans

(administered through Iowa State Univ.), 1998-2000.Member, Search Committee for Head of Department of Pharmaceutics and

Pharmacodynamics, College of Pharmacy, UIC, 1998.Chair, Search Committee for the faculty member in the area of cellular or molecular

immunology, and Director of the Institute for Tuberculosis Research, College of Pharmacy, UIC, 1998.

Chair, UIC College of Pharmacy Committee on Research, 1998-present.Chair, UIC College of Pharmacy Committee on Graduate Education, 1998-present.Member, UIC Senate Committee on Research, 1998-2000.Member (and Chair), American Society of Pharmacognosy Research Achievement Award

Committee, 1998-1999; 1999-2000; 2000-2001 (Chair).Chair, California Table Grape Commission Committee for Research, 1998-present.Member, Task Force for Research Support Services, Office of the Vice Chancellor for

Research, UIC, 1998-1999.Member, Task Force for Technology Transfer and Commercialization Programs, Office of

the Vice Chancellor for Research, UIC, 1998-1999.Member, Committee to Perform Internal Review of the Department of Political Science,

Office of the Vice Chancellor for Research, UIC, 1999.Chair, Search Committee for Head of the Department of Medicinal Chemistry and

Pharmacognosy, College of Pharmacy, UIC, 1999-2000.Chair, UIC College of Pharmacy Committee for prioritization and evaluation of clinical

11

protocols requiring IRB approval, College of Pharmacy, UIC, 1999.Member, Review Panel for the Selection of University Scholars, Office of the Provost, UIC,

2000.Member, AACP Paul Dawson Biotechnology Award Committee, 2000.Member, Task Force on Scholarship of Application, Office of the Provost, UIC, 2000.Member, Search Committee for the Director of the UIC Research Resources Center,

Office of the Vice Chancellor for Research, UIC, 2000-2001.Member, Graduate College Executive Committee, UIC, 2000-2002.Member, Search Committee for the appointment of technology transfer specialist, Office of

the Vice Chancellor for Research, UIC, 2000-2001.Member, Task Force on Small Research Grants for Graduate Students, UIC Graduate

College, 2000.Member, Search Committee for Head of Department of Biochemistry and Molecular

Genetics, College of Medicine, UIC, 2000-2002.Member, AACP Volwiler Research Award Committee, 2002.Chair, Review Panel for the Selection of University Scholars, Office of the Provost, UIC,

April 2002.Member, Subcommittee E (Cancer Epidemiology, Prevention and Control), National

Cancer Institute/NIH, 2003-2006.Member, AACR 2004 Cancer Epidemiology and Prevention Awards Committee, 2009-

2011.Member, Search Committee for the Director of for Vice Chancellor for Academic Affairs,

Univ. Hawaii at Hilo, 2012.Chair, Search Committee for Director of University Relations, Univ. Hawaii at Hilo, 2012.Member, Landon Foundation-AACR Innovator Award for Cancer Prevention Research

Scientific Review Committee, 2013-2015.Member, AACP Volwiler Research Award Committee, 2014.Chair, AACP Volwiler Research Award Committee, 2015.Chair, Search Committee for Dean of Nursing, Long Island University, Brooklyn, NY, 2016.Member, Search Committee for Vice Chancellor of Academic Affairs, Long Island

University, Brooklyn, NY, 2016.

Theses Committees

Mr. D. Berg, Department of Pharmacology, College of Medicine, UIC (M.D.-Ph.D. Program), 1983.

Mr. M. Hussain, Department of Pharmacodynamics, College of Pharmacy, UIC, 1983.Mr. I. Kim, Department of Pharmacodynamics, College of Pharmacy, UIC, 1984.Mr. G. Marcelle, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1984.Mr. C. Compadre, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1984.Mr. G. Marshall, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1985.Mr. F. Selan, Department of Pharmacology, College of Medicine, UIC, 1985.Ms. Y. Choi, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1985.Mr. J. Kim, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1987.Mr. M. Duncan, Department of Chemistry, College of Liberal Arts and Sciences, UIC,

1987.Mr. C. Wheeler, Department of Pharmacology, College of Medicine, UIC, 1989.Mr. C. Bergstrom, Department of Medicinal Chemistry and Pharmacognosy, UIC, 1989.

12

Mr. L. Kardono, Department of Medicinal Chemistry and Pharmacognosy, UIC, 1991.Mr. L. Zhao, Department of Chemistry, College of Liberal Arts and Sciences, UIC, 1991.Mr. L. Guo, Department of Chemistry, College of Liberal Arts and Sciences, UIC, 1991.Ms. H. Gong, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1991.Mr. A. Amarquaye, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1992.Ms. O. Ngassapa, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1992.Mr. K. Likhitwitayawuid, Department of Medicinal Chemistry and Pharmacognosy, College

of Pharmacy, UIC, 1992.Ms. K. Meepagala, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1993.Ms. Y. Lou, Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy,

UIC, 1993.Mr. B. O'Keefe, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1993.Mr. C.J. Chen, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1994.Mr. F. Hermann, Department of Chemistry, College of Liberal Arts and Sciences, UIC,

1994.Mr. G. Luo, Department of Pharmacology, College of Medicine, UIC, 1994.Mr. L. Zhang, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1995.Mr. H. Constant, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1996.Mr. S.-W. Yang, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1997.Mr. F.D. Horgen, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1997.Mr. J.W. Kosmeder II, Department of Chemistry, College of Liberal Arts and Sciences,

UIC, 1998.Ms. L.C. Chang, Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, UIC, 1998.Ms. Z. Dai, Department of Chemistry, College of Liberal Arts and Sciences, UIC, 1998.Mr. S. Fidanze, Department of Chemistry, College of Liberal Arts and Sciences, UIC,

2000.Mr. G.M. Bilcer, Department of Chemistry, College of Liberal Arts and Sciences, UIC,

2002.Ms. S. Grubjesic, Department of Chemistry, College of Liberal Arts and Sciences, UIC,

2003.

Grant and Manuscript Reviews (partial listing)

American Journal of Pathology, refereeBiochemical Pharmacology, refereeAmerican Journal of Pathology, refereeBiochimica et Biophysica Acta, refereeBioorganic & Medicinal Chemistry, refereeBritish Journal of Cancer, refereeCancer Detection and Prevention, refereeCancer Immunology and Immunotherapy, refereeCancer Prevention Research, refereeCancer Research, referee

13

Cancer Letters, refereeCancer & Nutrition, refereeCarcinogenesis, refereeCellular and Molecular Medicine, refereeChemical Research in Toxicology, refereeChemico-Biological Interactions, refereeChemistry & Biology, refereeClinical Cancer Research, refereeClinical Drug Investigation, refereeCombinatorial Chemistry and High Throughput Screening, refereeCurrent Drug Metabolism, refereeCurrent Pharmaceutical Biotechnology, refereeCurrent Pharmaceutical Design, refereeDNA and Cell Biology, refereeDrug Metabolism and Disposition, refereeEuropean Journal of Medicinal Chemistry, refereeFood and Chemical Toxicology, refereeFree Radical Biology & Medicine, refereeFuture Medicine, refereeInterciencia, refereeInvestigational New Drugs, refereeJournal of the American Chemical Society, referee Journal of Chromatography, refereeJournal of Ethnopharmacology, refereeJournal of Investigative Dermatology, refereeJournal of Medicinal Chemistry, refereeJournal of Molecular Endocrinology, refereeJournal of Medicinal Food, refereeJournal of Natural Products, refereeJournal of the National Cancer Institute, refereeJournal of Pharmaceutical Sciences, refereeJournal of Pharmacology and Experimental Therapeutics, refereeJournal of Pharmacy and Pharmacology, refereeJournal of Scientific Research-Science and Technology, refereeJournal of Zhejiang University – Science B, refereeLeukemia, refereeLife Sciences, refereeMarine Drugs, refereeMolecular and Cellular Endocrinology, refereeMolecular Cancer Therapeutics, refereeMolecular and Cellular Biochemistry, refereeMolecular Nutrition and Food Research, refereeMolecular Pharmacology, refereeMolecules, refereeNatural Product Letters, refereeNatural Product Research, refereeNature Biotechnology, refereeNature Medicine, refereeNeuroscience Letters, refereeNutrition and Cancer, refereeNutrition of Cancer, refereeOncogene, refereePharmaceutical Research, refereePhytochemical Analysis, referee

14

Phytochemistry, refereePhytomedicine, refereePhytotherapy Research, refereePlanta Medica, refereePLoS One, refereeRedox Report, refereeScience and Technology, refereeTetrahedron, refereeTransaction of the Illinois State Academy of Science, refereeToxicology and Applied Pharmacology, refereeToxicology & Environmental Chemistry, refereeCampus Research Board, University of Illinois at Chicago, reviewer.College of Medicine Committee on Research, University of Illinois at Chicago, reviewer.Special Reviewer, Bioorganic and Natural Product (BNP) Study Section, NIH, February,

1992.External Reviewer, University and Polytechnic Grants Committee, Hong Kong, 1993.External Reviewer, International Foundation for Science, Stockholm, 1994.NCI Site Visit Team for Program Project Application, Johns Hopkins University, October

1994.Reviewer, Proposal submitted to the Austrian Science Foundation, Vienna, Austria,

December 1994Reviewer, American Cancer Society, Nutrition and Carcinogenesis, June 1995.Reviewer, Proposal submitted to the International Foundation for Science, Stockholm,

Sweden, March 1996.Member, NIH Study Section to review applications submitted in response to RFA CA96-

002, "Dietary Exposure to and Effects of Plant Food Constituents," July 1996.Reviewer, proposal submitted to the International Foundation for Science, Stockholm,

Sweden, October 1996. Reviewer, Proposal "Biosynthesis of Artemisinin" submitted to University Grants

Committee, Hong Kong Research Grants Council, Hong Kong, 1996. Reviewer, Research proposal for the John Simon Guggenheim Memorial Foundation,

November 1996.Reviewer, Research proposal for the John Simon Guggenheim Memorial Foundation,

March 1997.Reviewer, Proposal submitted to the Israel Science Foundation, Jerusalem, Israel, April

1997.NCI Site Visit Team for M.D. Anderson Cancer Center, February 1998.Reviewer, Proposal submitted to the Cancer Research Campaign, London, England,

March 1998.External Reviewer, International Foundation for Science, Stockholm, 1998.Member, NIH Study Section Biological and Physiological Sciences Special Emphasis

Panel ZRG1 SSS-1 (2)B, March 28-29, 1999.Reviewer, Grant application submitted to Natural Sciences and Engineering, Research

Council of Canada, Ottawa, Canada, October 1999. Reviewer, Research proposal submitted to the Cancer Research Campaign, London,

England, December 1999.Reviewer, Research proposal submitted to the 1999-2000 Cooperative Grants Program of

the U.S. Civilian Research and Development Foundation, February 2000. Chair, Review Committee for Research Grant Applications Submitted to the California

Table Grape Commission, March 14, 2000.NCI Site Visit Team for Program Project Application, Johns Hopkins University, June 5-7,

2000.Member, NIH Study Section for Cancer Prevention Research Small Grant Program,

Special Emphasis Panel 2CA1 SRRB-7(01), July 18-19, 2000.

15

Reviewer, Proposal for Mississippi-Alabama Sea Grant Consortium, July 2000.Reviewer, Research proposal submitted to Natural Sciences on Engineering Research

Council of Canada, August 2000. Member, NIH Study Section for Cancer Prevention Research Small Grant Program,

Special Emphasis Panel 2CA1 SRRB-7(01), December 5-6, 2000.NCI Teleconference Review of Program Project Application, Johns Hopkins University,

January 18, 2001.Member, NIH Study Section for Innovative Cancer Complementary and Alternative

Medicine Initiative in Cancer Centers, Special Emphasis Panel 2CA1 SRRB-4(M1), February 19-21, 2001.

Chair, Teleconference, NIH/NCI Study Section for Small Business Innovation Research Program, Special Emphasis Panel ZCA1 SRRB-E(C1), March 19, 2001.

Reviewer, Proposal "Synthesis of Flavonoids as Selective Modulators of Multidrug Resistance P-Glycoprotein" submitted to University Grants Committee, Hong Kong Research Grants Council, Hong Kong, 2001.

Reviewer, Proposal “Peptide Antibiotics Engineering: Application of Enzymes in Synthesis of Combinatorial Libraries” submitted to University Grants Committee, Hong Kong Research Grants Council, Hong Kong, 2001.

Member, NIH Study Section for Chemoprevention of Tobacco-Related Cancers in Former Smokers, Special Emphasis Panel 2CA1 SRRB-E(J2), December 6, 2001.

Chair, Review Committee for Research Grant Applications Submitted to the California Table Grape Commission, March 2, 2002.

Chair, NIH Study Section for the Review of SBIR Topic 180, Isolation of Natural Products Using Super Critical Fluid Technology, March 19, 2002.

Reviewer, proposal submitted to the International Foundation for Science, Stockholm, Sweden, May 2002.

Reviewer, Research proposal submitted to the Cancer Research Campaign, London, England, May 29, 2002.

Reviewer, Teleconference, applications submitted to the RAND (Rapid Access to NCI Discovery Resources) program of NCI, June 13, 2002.

Reviewer, National Center for Complementary and Alternative Medicine/National Cancer Institute, Special Emphasis Panel ZAT1 G (08), PAR-02-040 CAM and Oncology, June 17-18, 2002.

Member, Site Visit Team, Review of Basic Research Laboratory, National Cancer Institute Intramural Organization, Frederick, MD, July 9-11, 2002.

Chair, California Table Grape Commission Scientific Advisory Panel, 2003 Research Program Proposal Review Meeting, Fairmont Hotel, Chicago, Illinois, March 3, 2003.

Member, Special Emphasis Panel, Developmental/Pilot Projects in Cancer Complementary and Alternative Medicine, NCI/NCCAM Study Section, Marriott Bethesda Suites, Bethesda, Maryland, March 10-11, 2003.

Member, Oncology Application Review, Special Emphasis Panel, Developmental/Pilot Projects in Cancer Complementary and Alternative Medicine, NCI/NCCAM Study Section, Marriott Bethesda Suites, Bethesda, Maryland, June 9-10, 2003.

Member, Cancer Drug Development Peer Review Committee, American Cancer Society, Atlanta, Georgia, June 25-27, 2003.

Review of proposal for Mississippi-Alabama Sea Grant Consortium, June 2003. Reviewer, abstracts submitted for the 95th AACR Annual Meeting, November 2003. Review of proposal for City University of New York, December 2003. Reviewer, Natural Sciences and Engineering Research Council of Canada, NSERC

Discovery Grants Program, Committee #3, Ottawa, Canada, January 2004. Chair, California Table Grape Commission Scientific Advisory Panel, 2004 Research

Program Proposal Review Meeting, Fairmont Hotel, San Francisco, CA, March 16, 2004.

16

Reviewer, National Center for Complementary and Alternative Medicine/National Cancer Institute, Development/Pilot Projects in Cancer Complementary and Alternative Medicine (CAM) PAR02-040, March 8-10, 2004.

Reviewer, 2004 "Avon-NCI Progress for Patients" (PFP) Awards Program: A Special Public-Private Initiative in Early Phase Clinical Interventions in Breast Cancer” supported by a partnership between the Avon Products Foundation, Inc. and the National Cancer Institute (NCI), May 2004.

Reviewer, Subcommittee E (Cancer Epidemiology, Prevention and Control), National Cancer Institute/NIH, December 9, 2004.

Reviewer, Austrian Science Fund, January 2005. Chair, California Table Grape Commission Scientific Advisory Panel, 2005 Research

Program Proposal Review Meeting, Fairmont Hotel, Chicago, IL, March 1, 2005.Reviewer, 2005 "Avon-NCI Progress for Patients" (PFP) Awards Program: A Special

Public-Private Initiative in Early Phase Clinical Interventions in Breast Cancer” supported by a partnership between the Avon Products Foundation, Inc. and the National Cancer Institute (NCI), May 2005.

Reviewer, Subcommittee E (Cancer Epidemiology, Prevention and Control), National Cancer Institute/NIH, August 11-12, 2005.

Reviewer, Subcommittee E (Cancer Epidemiology, Prevention and Control), National Cancer Institute/NIH, October 4-5, 2005.

Reviewer, Subcommittee E (Cancer Epidemiology, Prevention and Control), National Cancer Institute/NIH, January 31-February 1, 2006.

Chair, California Table Grape Commission Scientific Advisory Panel, 2006 Research Program Proposal Review Meeting, Fairmont Hotel, Chicago, IL, February 27, 2006.

Reviewer, Teleconference with NCI Parent Committee, April 10, 2006.Reviewer, Research proposal submitted to the Swiss National Science Foundation, May

2006.Reviewer, Rapid Access to Intervention Development (RAID), National Cancer

Institute/NIH, May 24, 2006.Reviewer, Cancer Prevention, Control, and Population Sciences, National Cancer

Institute/NIH, Special Emphasis Panel/Scientific Review Group 2006/10 ZCA1 RPRB-5 (O3) (S), June 19-21, 2006.

Reviewer, Cancer Prevention, Control, and Population Sciences, National Cancer Institute/NIH, Special Emphasis Panel/Scientific Review Group 2006/10 ZCA1 GRB-I (O2), June 20-21, 2006.

Reviewer, Avon-NCI Progress for Patients Program, June 2006.Chair, California Table Grape Commission Scientific Advisory Panel, 2007 Research

Program Proposal Review Meeting, Omni Hotel, San Francisco, CA, March 5, 2007.

Reviewer, Novel Cancer Therapies SBIR/STTR, 2007/05 Council ZRG1 ONC-D 02 B, March 12-13, 2007.

Reviewer, National Center for Complementary and Alternative Medicine Special Emphasis Panel, ZAT1 SM (07), June 20-27, 2007.

Reviewer, Grant application, Grant Agency, Academy of Sciences of the Czech Republic, Czech Republic, September 2007.

Reviewer, Grant application, International Foundation for Science (IFS), Stockholm, Sweden, October 2007

Member, Scientific Advisor for International Foundation for Science (IFS), Stockholm, Sweden, 2007-present

Member, Internal Advisory Committee, University of Guam/Cancer Research Center of Hawaii Partnership, 2007-present.

Review of Program Project applications, National Cancer Institute, Rockville, MD, January 29-31, 2008.

17

Chair, California Table Grape Commission Scientific Advisory Panel, 2008 Research Program Proposal Review Meeting, San Francisco, CA, March 3, 2008.

Reviewer, Grant application, Austrian Science Fund, Vienna, Austria, June 2008.Standing Member, Subcommittee E (Cancer Epidemiology, Prevention and Control),

National Cancer Institute/NIH, 2003-2007 (the study section meets three-times/year).

Reviewer, Grant application, International Foundation for Science (IFS), Stockholm, Sweden, October 2007

Reviewer, Program Project applications, National Cancer Institute, Rockville, MD, Jan. 29-31, 2008

Reviewer, Grant applications, California Table Grape Commission, San Francisco, CA, March 2008

Reviewer, Grant application, Austrian Science Fund, Vienna, Austria, June 2008Reviewer, Research grant application, Global Research Network Program 2008, Division

of International Affairs, Korea Research Foundation, November 2008Reviewer, Research grant application, AMRC, Cancer Research UK, Dec. 2008Reviewer, Research grant application, Cancer Society of New Zealand, Jan. 2009Reviewer, Grant applications, California Table Grape Commission, San Francisco, CA,

March 2009Reviewer, Application for First IFS Research Grant, International Foundation for

Science, Stockholm, Sweden, April 2009.Reviewer, Research project submitted to Ohio Cancer Research Associates, Columbus,

Ohio, May 2009.Reviewer, National Cancer Institute Special Emphasis Panel, NCI-ARRA Competitive

Revisions and GO Grants - Pre-Clinical, Drug Discovery & Imaging, July 2009.Theme reviewer for anti-cancer agents, Scientific Committee of the 57th International

Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Geneva, Switzerland, August 2009.

Member, Scientific Program Committee, 50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, HI, July 2009.

Reviewer, RC4 Community Infrastructure Grants, Healthcare Delivery and Methodologies (HDM) Integrated Review Group, NIH (ZRG1 HDM-D meeting). February 2010.

Reviewer, Grant application, North Carolina Biotechnology Center, March 2010.Reviewer, Grant applications (2), International Foundation for Science (IFS), Stockholm,

Sweden, April 2010.Reviewer, three program project applications for Masonic Cancer Center, University of

Minnesota, August 2010.Reviewer, Grant applications (2), International Foundation for Science (IFS), Stockholm,

Sweden, December 2010.Review of Revised Grant Application, North Carolina Biotechnology Center, January 2011.Review of Grant Application, Cancer Research UK, London, January 2011.Reviewer and Committee Chair, Grant applications, California Table Grape Commission,

March 2011.Reviewer, Grant Application, Austrian Science Fund, Vienna, Austria, March 2011.Reviewer, Special Emphasis Panel, National Center for Complementary & Alternative

Medicine, NIH, Natural Products RFA ZAT1 SM(23), March 31-April 1, 2011.Reviewer, Grant Application, Research Grant Council (RGC) of Hong Kong, April 2011.Reviewer, Special Emphasis Panel/Scientific Review Group, Chemo/Dietary Prevention

Study Section, NCI, June 9-10, 2011.Reviewer, Special Emphasis Panel, National Center for Complementary & Alternative

Medicine, NIH, Natural Products RFA ZAT1 SM(24), July 21-22, 2011.Reviewer, Special Emphasis Panel/Scientific Review Group, Chemo/Dietary Prevention

Study Section, NCI, February 9-10, 2012.Reviewer and Committee Chair, Grant applications, California Table Grape Commission,

18

March 2012.Reviewer, National Center for Complementary & Alternative Medicine, National Products

RFA, ZAT1 SM(27), NIH, July 19-20, 2012.Reviewer and Committee Chair, Grant applications, California Table Grape Commission,

March 2013.Reviewer, Research Grant Council (RGC) of Hong Kong (two proposals), March 2013.Reviewer, Grant application, International Foundation for Science (IFS), Stockholm,

Sweden, May 2013.Reviewer, Special Emphasis Panel, National Center for Complementary & Alternative

Medicine, NIH, Natural Products RFA ZAT1 SM(23), March 31-April 1, 2011.Reviewer, National Center for Complementary & Alternative Medicine, NIH, ZAT1 HS-13

Clinical Studies of Complementary and Alternative Medicine, July 9, 2013.Reviewer (stage 2), Special Emphasis Panel, National Center for Complementary and

Alternative Medicine (NCCAM/NIH) together with the Office of Dietary Supplements (ODS/NIH) and the National Cancer Institute (NCI/ NIH), Mechanistic Research on CAM Natural Products (RFA-AT-11-001), Sept. 13, 2013.

Reviewer, National Center for Complementary & Alternative Medicine, NIH, ZAT1 HS-14 Training, Education and AREA grants. October 25, 2013.

Reviewer, 2013/14 Centres of Research Excellence (CoREs) funding round, Royal Society of New Zealand, January 2014.

Reviewer, Grant Application, Austrian Science Fund, Vienna, Austria, March 2014.Reviewer and Committee Chair, Grant applications, California Table Grape Commission,

March 2014.Reviewer, two grant applications submitted to the International Foundation for Science

(IFS), Stockholm, Sweden, April 2014.Reviewer, grant application submitted to the Scientific Research Support Fund, Amman-

Jordan, April 2014.Reviewer, Special Emphasis Panel/Scientific Review Group, Oncological Sciences Grant

Applications [ZRG1 OTC-N (80)], NCI, June 24, 2014.Reviewer, Special Emphasis Panel, Centers of Biomedical Research Excellence

(COBRE), NIGMS, July 2014.Reviewer, National Center for Complementary & Alternative Medicine, NIH, ZAT1 SM 34

Botanical Dietary Supplement Research Centers (BDSRC) (P50), December 17-18, 2014.

Reviewer, National Center for Complementary & Alternative Medicine, NIH, ZAT1 SM 35 Centers for Advancing Natural Products Innovation and Technology Centers (CANPIT) (U41), December 19, 2014.

Reviewer, grant application submitted to the International Foundation for Science (IFS), Stockholm, Sweden, April 2015.

Reviewer, two grant applications submitted to the National Science Center, Kraków, Poland, April 2015.

Reviewer, grant application submitted to the Research Grants Council (RGC) of Hong Kong, April 2015.

Reviewer, ZCA1 SRB-L (O1): NCI Omnibus R03 &R21 SEP-6 Review Committee, June 9-10, 2015.

Reviewer, “Training and Education” review meeting held by the National Center for Complementary and Alternative Medicine (NCCAM/NIH), July 1, 2015.

Reviewer, application submitted to the the International Foundation for Science (IFS), Stockholm, Sweden, June 2016.

Reviewer, application submitted to Medical Research Council, Research Councils UK, July 2016.

19

Miscellaneous External Reviews

Reviewer, Promotion dossier for the President, University of Jordon, Irbid, Jordan, May 1995.

External reviewer, Ph.D. thesis, Ms. Rubeena Saleem, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan, July 1995.

External reviewer, Ph.D. thesis, Mr. Padma G.M. Rao, Department of Pharmacology, Kasturba Medical College, Mangalore University, Manipal, India, January 1996.

External reviewer, M.S. thesis, Ms. Liz A. Sánchez Marcano, School of Pharmacy, University of Puerto Rico, June 1996.

External reviewer, Ph.D. thesis, Mr. Afgan Farooq, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan, July 1996.

Reviewer, Book proposal submitted to Academic Press dealing with brassinosteroids, September 1996.

Reviewer, Promotion dossier for the Hong Kong University, Hong Kong, January 1997.Reviewer, Funding continuation for a principal grant-holder for Foundation for Research

and Development, Pretoria, South Africa, January 1997.Reviewer, Research proposal for the Louisiana Education Quality Support Fund, Baton

Rouge, LA, January 1997.Reviewer, Candidates for the position of full professor (C4), University of Munich,

Department of Pharmaceutical Biology, December 1997.Reviewer, Book proposal submitted to John Wiley & Sons, Ltd., "Methods in Phytotherapy

Research. Vol. 2. Chemotherapy, Toxicology and Clinical Evaluation" (Williamson et al.), December 1997.

Reviewer, Candidate for Regents' Professorship at the University of Arizona, Tucson, Arizona, January 1999.

Reviewer, Candidate for promotion to the rank of Professor, Cornell University, New York, April 1999.

Reviewer, Candidates for tenured faculty positions, University of Karachi, Karachi, Pakistan, September 1999.

Reviewer, Book proposal submitted to Academic Press regarding dietary supplements, October 1999.

Reviewer, Candidate for promotion to the rank of Full Professor, Rutgers, The State University of New Jersey, New Brunswick, NJ, April 2000.

Reviewer, Candidate for promotion and tenure, University of Karachi, Karachi, Pakistan, August 2000.

Reviewer, Candidate for promotion and tenure, University of Mississippi, University, MS, September 2000.

External reviewer, Ph.D. thesis, Ms. Shagufta Khatoon, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan, November 2001.

Reviewer, Proposal to be submitted to the Broad Medical Research Program, Inflammatory Bowel Disease Grants, The Eli and Edythe L. Broad Foundation, February 2002.Reviewer, Candidate for promotion and tenure, University of the Punjab, Lahore, Pakistan, April 2003.

Reviewer, Candidate for promotion and tenure, University of Karachi, Karachi, Pakistan, June 2003.

Reviewer, Candidate for promotion and tenure, Northwestern University, Chicago, IL, August 2004.

Reviewer, Proposal submitted to The United States Civilian Research & Development Foundation, Cooperative Grants Program, October 2004.

Reviewer, Candidate for promotion and tenure, University of Nebraska Medical Center, October 2004.

Reviewer, Candidate for Distinguished Professor, The University of Utah, November 20

2004.Reviewer, Two candidates for promotion and tenure, University of the Punjab, Lahore,

Pakistan, March 2005.Reviewer, Candidate for Special Fellow, The Leukemia & Lymphoma Society, November

2005. Reviewer, Candidate for promotion and tenure, University of Pittsburgh, February 2006.Reviewer, Book proposal submitted to Jones and Bartlett Publishers, May 2006.Reviewer, Research project submitted to the Fonds National de la Recherche, June

2006.Reviewer, Candidate for full professor with tenure, University of Illinois at Chicago,

September 2007Reviewer, Candidate for full professor with tenure (new appointment), The Ohio State

University, October 2007 Chair, Farnsworth Research Achievement Award session, 50th Annual Meeting of the

American Society of Pharmacognosy, Honolulu, HI, July 2009.Reviewer, Candidate for Academia Sinica Investigator Award, Office of Academic

Affairs, Academia Sinica, Taipei, Taiwan, July 2009.Member, Selection Committee, Eighth AACR-Prevent Cancer Foundation Award for

Excellence in Cancer Prevention Research, 2009-2010.Member, Selection Committee, Nineteenth AACR-American Cancer Society Award for

Research Excellence in Cancer Epidemiology and Prevention, 2009-2010.Review of book proposal submitted to The University of Arizona Press, Feb. 2010.Reviewer, Promotion and tenure case, University of Illinois at Chicago, August 2010. Review of complete manuscript submitted to The University of Arizona Press, January

2011.Review of promotion dossier to rank of full professor Petra University, Jordan, January

2012.Review of promotion dossier to rank of full professor for Sultan Qaboos University,

Oman, February 2012.Provided evaluation and nomination for recipient of the TÜBİTAK Science Award,

Turkey, March 2012.Review of promotion dossier to rank of full professor University of Jordan, Amman,

Jordan, May 2012.Review of promotion dossier to rank of full professor Seoul National University, Seoul,

Korea, May 2012.Review of promotion dossier to rank of associate professor with tenure, University of

Rhode Island, Sept. 2012.External Examiner of Ph.D. dissertation, University of Pretoria, June 2013.Review of promotion dossier to rank of full professor, University of Mississippi Medical

Center, September 2014.Review of candidate for promotion to Senior Scientist, NCI intramural program, March

2015.External reviewer for prevention program, Purdue University Cancer Research Center,

June 2016.External Examiner, Habilitation Thesis, University of Vienna, July 2016.

Editorial Positions

I am currently Editor-in-Chief of the journal Pharmaceutical Biology. Additional editorial activites follow.

International Journal of Pharmacognosy, member of Editorial Board, 1986-1988; Associate Editor, 1989-1991; Editor-in-Chief, 1991-1996; Editor for High Capacity

21

Screening Articles, 1996-1998.Combinatorial Chemistry and High Throughput Screening, Editor-in-Chief, 1997 (while

under development by Bentham Science Publishers); member of Editorial Board, 1997-present.

Current Medicinal Chemistry, member of Editorial Board, 1997-present.Journal of Cellular Biochemistry (Chemoprevention Supplements), member of Editorial

Committee, 1997-present.Current Opinion in Oncologic, Endocrine and Metabolic Drugs, member of the Editorial

Board, 1998-present.Phytotherapy Research, member of the Editorial Board, 1998-present.Fitoterapia, member of the Editorial Board, 1998-present. Integrative Cancer Therapies, member of the Advisory Board, 2001-present.Natural Product Letters, member of the Editorial Board, 2002-present.International Journal of Cancer, member of the Editorial Board, 2003-present.Journal of Pharmacy and Pharmacology, member of the Editorial Board, 2003-present.Current Bioactive Compounds, member of the Editorial Board, 2004-present.Nutrition and Cancer, member of the Editorial Board, 2006-present.Chief Editor, Natural Products Topic Area, Encyclopedia of Life Support Systems,

coordinated by the UNESCO-EOLSS Joint Committee.

Listing in Reference Sources

"Who's Who in Frontier Science and Technology", "Who's Who of Professionals and Resources in Cancer", "Who's Who in the Midwest", "Who's Who of Emerging Leaders in America", "Who's Who in the World", "Who's Who in America", "Who's Who in Medicine and Healthcare"

Patents/Disclosures

A.D. Kinghorn, C.M. Compadre, and J.M. Pezzuto. Low Cariogenic Sweetening Agents. U.S. Patent 4,806,379, February 28, 1989. Low cariogenic sweetening agents comprising racemic 6-(1',5'-dimethyl-1-hydroxyhex-4'-en-1'-yl)-3-methyl-2-cyclohexen-1-one.

T.K. Das Gupta and J.M. Pezzuto. Method and Composition for Selectively Inhibiting Melanoma using Betulinic Acid. U.S. Patent 5,658,947, August 19, 1997.

J.M. Pezzuto, T.K. Das Gupta, and D.S.H.L. Kim. Method and Composition for Selectively Inhibiting Melanoma. U.S. Patent 5,869,535, February 9, 1999.

J.M. Pezzuto, T.K. Das Gupta, and D.S.H.L. Kim. Methods of Manufacturing Betulinic Acid. U.S. Patent 5,804,575, September 8, 1998.

J.M. Pezzuto, T.K. Das Gupta, M.L. Schmidt, K. Kuzmanoff, L. Ling-Indeck, and Kim, D.S.H.L. Kim. Method and Composition for Treating Cancers, U.S. Patent 5,962,527, October 5, 1999.

J.M. Pezzuto, R.C. Moon, and M. Jang. Cancer Chemopreventive Composition and Method. U.S. Patent 6,008,260, December 28, 1999.

J.W., Kosmeder, L. Song, R.C. Moon, and J.M. Pezzuto. Use of 4'-Bromoflavone in a Cancer Chemopreventative Composition and Method. U.S. Patent 6,046,231, April 4, 2000.

H. Mehdi, Fong, H.H.S. and J.M. Pezzuto. Treatment of Hepatitis B Virus Infection. 22

Invention disclosure.

J.M. Pezzuto, J.W. Kosmeder, and Z.-Q. Xu. Methods of Preparing and Use of Prodrugs of Betulinic Acid Derivatives. Provisional Patent Filed, August 2000.

A.D. Kinghorn, J.M. Pezzuto, D. Lee, and K.P.I. Bhat. Aromatase Inhibitors from Broussonetia papyrifera. Invention disclosure filed, January 2001.

J.M. Pezzuto and E. Mata-Greenwood. Cancer Chemopreventive Compounds and Compositions and Methods of Treating Cancers. Provisional Patent Filed, February 2001.

A.D. Kinghorn and J.M. Pezzuto. Tropane Alkaloid Multidrug Resistance Inhibitors from Erythroxylum pervillei. Invention disclosure filed, April 12, 2001.

J.M. Pezzuto, T.K. Das Gupta, and D.S.H.L. Kim. Method and Composition for Selectively Inhibiting Melanoma. U.S. Patent 6,225,353, May 1, 2001.

G.A. Cordell, J.M. Pezzuto, K.H. Lee, and H.B. Chai. Selective Cytotoxicity of Berberine. Invention disclosure filed, May 2001.

J.W. Kosmeder, R.M. Moriarty, and J.M. Pezzuto. Use of Oxomate as a Chemopreventive Agent in the Intervention of Carcinogenesis. Invention disclosure.

J.M. Pezzuto and J.D. McChesney. Cancer Chemopreventative Compounds and Compositions and Methods of Treating Cancers. U.S. patent application serial no. 10/066,809, February 4, 2002; PCT application, serial no. PCT/US02/03134., filed February 4, 2002.

J.M. Pezzuto, R.C. Moon, M.-S. Jang, A. Ouali, S. Lin, and K. Slowing-Barillas. Pharmaceutical Formulations of Resveratrol and Methods of Use Thereof. U.S. Patent 6,414,037, July 2, 2002.

J.M. Pezzuto, J.D. McChesney, M.A. Cuendet, and L. Helson. Cancer Chemopreventative Compounds and Compositions and Methods of Treating Cancers. U.S. patent application serial no. 10/066,809, July 22, 2002; PCT application, serial no. PCT/US02/23543, filed July 24, 2002.

A.D. Kinghorn, J.M. Pezzuto, D. Lee, and K.P.L. Bhat. Aromatase Inhibitors from Broussonetia papyrifera. U.S. patent application, serial no. 10/205,029, filed August 7, 2002; PCT application, serial no. PCT/US02/23,618, filed August 7, 2002.

J.M. Pezzuto, J.W. Kosmeder, II, Z.-Q. Xu, N.E. Zhou, and M.E. Goldsmith. Method of Preparing and Use of Prodrugs of Betulinic Acid Derivatives. Patent application filed August 15, 2001, U.S. 6,569,842 B2, May 27, 2003.

A.D. Kinghorn, J.M. Pezzuto, G.L. Silva, B. Cui, and M. You. Tropane Alkaloid Multidrug Resistance Inhibitors from Erythroxylum pervillei and Use of the Same. U.S. Patent Application No. 10/119,874, June 28, 2005, U.S. 6,989,396 B2, January 24, 2006.

M.S. Cushman, A. Maiti, and J.M. Pezzuto. Casimiroin, Analogs Thereof, and Methods for Treating Cancer. Provisional Patent Application No. 61/153807, filed February 20, 2009.

M.S. Cushman, J.M. Pezzuto, and A. Maiti. Chemotherapeutic Flavonoids, and Syntheses Thereof. December 12, 2007, Purdue Reference Number 64681.00.WO, PCT International Serial No.: PCT/US2007/087283, Barnes & Thornburg Docket Number 3220-

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204578.

M.S. Cushman, J.M. Pezzuto, and A. Maiti. Chemotherapeutic Flavonoids, and Synthesis Thereof. U.S. Patent No. 8,946,287 B2, February 3, 2015.

J.M. Pezzuto. Antioxidative Stress Compositions, Methods of Preparing and Uses Thereof. Provisional Patent Application U.S. Serial No.: 62/340,364, filed May 23, 2016.

Licensing Agreement s

Agreement with BioActive Natural Products, St. Louis, MO, involving $50,000 up-front licensing fee, research contracts, and milestone payments, for the development of betulinic acid.

Agreement with Advanced Life Sciences for the development and clinical evaluation of betulinic acid.

Drug Development Applications

T.K. Das Gupta and J.M. Pezzuto. RAID Application to NCI, submitted October 1999 for the development of betulinic acid. Approved and Funded.

J.M. Pezzuto and J.W. Kosmeder. RAPID Application to NCI, submitted October 1999 for the development of 4'-bromoflavone. Approved and Funded.

J.M. Pezzuto and J.W. Kosmeder. RAPID Application to NCI, submitted November 2000 for the development of four flavonoids from Broussonetia papyrifera. Approved and Funded.

Consulting /Advisory Groups

1981-1987 Biological consultant, Otsuka Pharmaceutical Co., Osaka, Japan1981-1983 Biological consultant for contract entitled "Studies to Identify, Isolate, Develop and

Test Naturally Occurring, Noncariogenic Sweeteners that May be Used as a Dietary Sucrose Substitutes," Principal Investigator, A.D. Kinghorn.

1982 Consultant, WBBM-TV, Chicago. News series entitled "Cashing in On Cancer."1982-1983 United Nations Centre for Science and Technology for Development.

Consultations regarding the potential toxicity of Endod.1983 Consultations with Dr. C.O. Akerele, Program Manager, World Health Organization

Traditional Medicine Program (toxicity of traditional medicine plants).1983-1988 U.S.-Pakistan Cooperative Science Program. Development of proposals jointly

with Dr. Atta-ur-Rahman, Co-Director, H.E.J. Research Institute of Chemistry, Karachi, Pakistan.

1983 Consultant, chemical-mediated genetic toxicity, Toxicology Research Laboratory, University of Illinois at Chicago.

1984 Consultant, assessment of genetic toxicity of antifertility agents, Dr. L.J.D. Zaneveld, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois.

1985-1988 Consultant, assessment of genetic toxicity of sweet-tasting chemicals, General Foods Corp., Tarrytown, N.Y.

1986 Member, Advisory Committee on Plant Molluscicides, WHO, Geneva, Switzerland, 15-16 December.

1989 Consultant, evaluation of book proposals submitted for publication, VCH Publishers, New York, NY.

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1990-1995 Consultant for RO1 DE08937 "Noncariogenic Intense Natural Sweetener." A.D. Kinghorn, Principal Investigator.

1992 Consultant, biological activity of vitamin D analogs, LUNAR, Madison, Wisconsin.1992-1998 Member, Advisory Committee, Center for Pharmaceutical Biotechnology, College

of Pharmacy, University of Illinois at Chicago.1993-1998 Member, Scientific Advisory Committee, Institute for Tuberculosis Research,

University of Illinois at Chicago.1993-1995 Consultant, Steroids Inc., Chicago, IL.1993-1996 Consultant, MediChem Research, Inc., Darien, IL.1993 Consultant for the Advisory Board, Hong Kong Research Grants Council, Hong

Kong.1993 Consultant, M & M Mars, Hackettstown, New Jersey.1994 Consultant, Preventive Nutrition Consultants, Inc., Woodinville, WA.1994 Review of Diploma Course in Plant Drugs, for Division of Plant Drug Research,

Department of Botany, S.V. University, Tirupati, India.1994-1998 Consultant for contract with Glaxo Wellcome Research and Development (Plant

Acquisition and Research Training Agreement), D. Doel Soejarto, UIC, Principal Investigator.

1995 Consultant for the research program of Dr. Arun K. Ghosh, Department of Chemistry, UIC, development of farnesyl transferase inhibitors.

1995-2000 Consultant for R29 grant application submitted to NIH by Dr. Judy L. Bolton, Competing Mechanisms of Catechol Toxicity.

1996 Consultant for project "Bioactivation of Estrogens to Quinoid Metabolites," Judy L. Bolton, UIC, Principal Investigator.

1996-1999 Consultant for project NIH-AREA grant application dealing with fungal metabolism of betulinic acid, Northeast Louisiana University, Samir A. Kouzi, Principal Investigator.

1996 Consultant for American Cancer Society project "Study of Signal Transduction Mechanisms of Chemopreventive Agents," A.-N. Tony Kong, UIC, Principal Investigator.

1997 Consultant for FIRST application submitted to NIH, Mary Lou Schmidt, UIC, Principal Investigator.

1997-1999 Consultant for Pharmascience, Montreal, Quebec, Canada.1997 Member of External Advisory Committee, program project entitled "Mechanism-

Based Discovery of Anticancer Natural Products," University of Hawaii at Manoa, Gregory M.L. Patterson, Principal Investigator.

1998-present Chair, Scientific Advisory Committee, California Table Grape Commission, Fresno, CA.

1998 Consultant for R21 grant submitted to NIH by Hayat Alkan-Onyuksel entitled "Innovative VIP Receptor Scintigraphy of Breast Cancer."

1998 Welch's Oncology Advisory Group, New York, NY.1998-2000 Organizing committee for program supported by the Iowa Soybean Promotion

Board, D. Birt, Iowa State Univ., Principal Investigator.1998-2006 Member of External Advisory Committee, Research Centers at Minority Institutions

Program, University of Puerto Rico, San Juan, PR, Osvaldo Rosario, Principal Investigator.

1998-2006 External Scientific Advisor, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii.

1998 Member of Advisory Group, Quantitative Methods Support Core for Biomedical Researchers, School of Public Health, UIC.

1998-2000 Faculty Mentor for Recardo Guerrero, University of Puerto Rico, San Juan, Puerto Rico.

2000-2002 Member of Scientific Advisory Board, MediChem Research, Lemont, Illinois.2002 Consultant for Workshop, Challenges and Opportunities for Intramural

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Implementation of State-of-the-art Biomolecular Lead-Discovery Infrastructure within the NCI Center for Cancer Research, NCI-Frederick, Frederick, MD.

2011-2013 Member, Hilo Medical Center Foundation, Hilo, HI.

Examples of Public Service/Relations/Communications

Group Leader for Focus Group involving 12 regional high school teachers to consider implementation of biotechnology in secondary education, Jan. 20, 1994.

Research quoted in Peoria Journal Star's Health & Fitness Section, Jan. 20, 1994.Appearance on WLS (Channel 7) Evening News (ABC affiliate in Chicago) concerning diet

and cancer, April 28, 1994.Appearance on WLS (Channel 7) Evening News (ABC affiliate in Chicago) concerning

cancer chemoprevention, May 5, 1994.Host for 32 Annual MIKI (Minnesota, Illinois, Kansas, Iowa) Meeting, May 20-22, 1994.Press releases: "Mom was right: Eat your vegetables." Bridgeport/Back of the Yards Extra,

June 23, 1994; Michigan Chronicle, Aug. 3, 1994.Interview by Health Magazine, Aug. 23, 1994.Quoted in fall issue of Healthwatch, Canada's only national health, fitness and wellness

magazine (750,000 readers).Interview for article in J. Natl. Cancer Inst., Sept. 13, 1994.Interview for 48 Hours (CBS Primetime), Sept. 14, 1994.Interview for Vogue Magazine, Sept. 23, 1994.UIC News, feature article entitled "Researcher Finds a Reason to Eat Cabbage: It May

Fight Cancer," October 19, 1994.Interview with Health Magazine, Dec. 15, 1994.Major contributor to story for Mirabella Magazine.Interview by Nutrition International, Feb. 15, 1995.Consultation with WTVO TV, Rockford, IL, regarding drug activity of DMSO, March 9,

1995.Interview by UIC News Bureau regarding recent drug discoveries made in cancer

chemotherapy and chemoprevention, March 9, 1995.Interviews with Voice of America, Associated Press, and Cox News Service regarding the

antitumor activity of betulinic acid, a discovery from our laboratory for the treatment of melanoma, March 16-17, 1995.

Coverage of work presented at a "Late Breaking Research" session of the American Association of Cancer Research, regarding the antitumor activity of betulinic acid: CNN, CBS radio, NBC radio, Chicago Sun Times, Chicago Tribune (news section and Kids section), NY Times, Philadelphia Inquirer, San Francisco Chronicle, UIC News (front page story), Paul Harvey, CBC radio (live), Austrian Broadcasting Corp. (live), Australian press and radio, Medical Post (Canada), all major TV stations in Chicago (NBC, CBS, ABC, WGN), various magazines [Dermatology Times (Vol. 16 (5), p.1), Nursery Management and Production, Skin & Allergy News].

Interview with Channel Two News (CBS), Chicago, concerning breast cancer and nutrition, April 7, 1995.

Press release by UIC News Bureau regarding recent drug discoveries made in cancer chemoprevention as reported in Nature Medicine, April 12, 1995.

Interview with Channel Seven News (CBS), Denver, concerning skin cancer and treatment, April 18, 1995.

Participation in the series New Explorers, Bill Kurtis Productions, regarding the development of betulinic acid and natural product drug discovery.

Parade Magazine (supplement to Chicago Tribune), work cited in "Nutrients in Plants May Fight Cancer," May 14, 1995.

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Feature article in UIC News, "Flora Power: Global Search for Plants that Fight Cancer," May 17, 1995.

Interview by WGN, Channel 9, Chicago, Functional Foods and Recent Discoveries in Natural Product Drugs, May 22, 1995.

Interview for The Skin Cancer Foundation quarterly newsletter, Sun and Skin News (Vol. 12), "Birch Bark Takes Bite Out of Malignant Melanoma," May 30, 1995.

University of Illinois Alumni Assoc. Magazine, Vol. 7, p.11, "Common Tree Bark Yields Potential Skin Cancer Cure," May/June 1995.

Interview with Thomson Health Care Communications, Toronto, May 31, 1995.Contributed to article with National Wildlife Federation, Vienna, Virginia, "Why Save That

Species," June 1995 (Oct./Nov. Issue)Contributed to article with Chatelaine, Toronto, July 1995 (published in Oct. 1995).Interview for article with New Woman, New York, dealing with melanoma, August 1995.Interview with CBC radio, St. Johns, Canada, dealing with birch and betulin, Sept. 27,

1995.Interview with Susan Milius, U.P.I., regarding betulinic acid and melanoma, Sept. 29,

1995.Contributed to television coverage of betulinic acid by At Discovery Canada, Discovery

Channel, Ontario, Canada, aired on Oct. 2, 1995.Interview with BBC International, October 6, 1995.Interview with Chris Edwards for article dealing with betulinic acid to be published in

Environmental Health Perspectives, Nov. 12, 1995.Interview with Kathy Bond-Borie for article dealing with brassinin and cancer

chemoprevention, Eating Well Magazine, Jan. 10, 1995.Consultation and laboratory work conducted with network (ABC) television show 20/20,

dealing with health foods, Jan. 1996.Interview with Carolyn Strange for an article to be published in the NCRR Reporter dealing

with natural product drug discovery at UIC, March 5, 1996 (Searching the Surf and Turf for New Drugs, NCRR Reporter, 20 (3): 10-11, 1996).

Interview with Susan Smith for an article to be published in Prevention magazine dealing with the prevention of skin cancer, March 8, 1996 (Natural Medicine, Looking for Healing Plants, Prevention, pp. 15-17, July 1996).

Interview with Carla Beecher for an article to be published University of Illinois Alumni Magazine dealing with functional food for health (cancer chemoprevention), March 27, 1996 ["Food You Can Use", Illinois Quarterly 8 (6): 19-21, 1996].

Interview with German Press and German Public Radio regarding cancer chemoprevention, Sept. 11, 1996.

Interview with Alison Mack for The Scientist dealing with Chinese herbs as a source of drugs for Western medicines, Dec. 4, 1996.

Interview with UIC News concerning cancer chemoprevention and functional foods for health, Dec. 10, 1996.

Examples of coverage of resveratrol as reported in Science (January 10-20, 1997): Linda Ciampa, CNN; Sergio Dacunha, Global TV Network Brazil; Andrew Luckbaker, BBC London; Jane Brody, New York Times and International Herald Tribune (both, front page); Paul Recer, Associated Press (distributed worldwide); Neil Gross, Business Week; Chris Joyce, National Public Radio (All Things Considered); Betty Chin, CBS Evening News with Dan Rather; Joseph Corbella, daily newspaper from Barcelona, Spain; Janet Sutherland, Illinois Radio Network; Joanne Kennen, Reuters; Angela Lavrat, Medical Tribune; Bob Cook, Newsday; Susan Millius, UPI; Richard Stone, Science; Lee Boyne, Scripts Howard News Service; Renee Sanchez, ABC Evening News; Franklin Cater, NBC Radio; Jerome Bodlander, AP Radio; Steve Cohen, WCBS Radio; Michael Noble, CBS Radio Network; David Shaper, WBEZ Radio; Bill Cameron and Larry Langford Show, WMAQ Radio (live); Quentin Letts, London Times; Gloria Tang, Discovery Channel; Sarah

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Owens, NBC Affiliate, Raleigh, NC; David Boodell, WBEZ (Mara Tapp Show, live); Richard Doulin, BBC (live); The Wine Spectator; Steve Cochran Show, AM 1000 (live); Bruce Dixon, AMA Radio; Trina Chang, American Health Magazine; WAMC, Albany; Amy Sirot, National Public Radio (New York, Talk of the Nation: Science Friday, live, with Director of NCI); January 9th Press Conference at UIC COP. Attending: Local channels 2, 5, 7, 9, 32 and 44; WGN, WMAQ and VOA radio; the Sun-Times (front page) and the Daily Herald; NCRR Reporter; Prevention magazine.

Press conference held at Annual Meeting of the Am. Assoc. Cancer Res. concerning diet and cancer chemoprevention, San Diego, CA, April 16, 1996.

Interview with MS/NBC OnLine, concerning diet and cancer, San Diego, CA, April 16, 1997.

Interview with 141- KERN-AM radio, Bakersfield, CA, concerning resveratrol and cancer prevention, April 17, 1997.

Anticancer Agent Found Through the Grapevine, NCRR Reporter, 21: 3, 1997.Interview with Ernie Mandell of Reuters, concerning the role of cancer chemopreventive

agents in human health, May 21, 1997.Interview with Thomas Matthews, Senior Editor of the Wine Spectator, concerning cancer

prevention and general aspects of life in Chicago, June 4, 1997.Feature article in Chicago Magazine, Medicine Show, pp. 34-47, July 1997.Feature article in UIC College of Pharmacy Alumni News, The Battle Goes On, July 1997.Interview with Steve Frankel, Great Lakes Radio Consortium, Natural Products Drugs,

August 5, 1997.Interview with Robert Barnett, quoted in Womans Day article Eat Your Way Healthy: 14

Powerful Remedies-As Close as Your Supermarket, issue of March 10, 1998.Quoted in Cosmopolitan article Breast Cancer Report: Life After Linda McCartney, p. 194,

July 1998.Interview with Karen Brooks, Fort Worth Star Telegram, diet and cancer, Sept. 8, 1998.Appearance on WMAQ-TV (ch. 5, NBC), discussion of plants from around the world useful

for treating diseases, with emphasis on UIC work, Sept. 14, 1998.Appearance on local and national Italian television stations, interviews on grapes and

cancer chemoprevention with emphasis on resveratrol, November 26, 1998.Interview with Sari Harrar for article to be published in Prevention magazine (Vol. 51, No.

5, May 1999), resveratrol and cancer prevention, January 1999.Interview with Stacie Farb, Total Nutrition News (syndicated radio), update and health

benefits of grapes, February 8, 1998.Article entitled "UIC Researchers Awarded $6.21 Million to Discover Cancer-Preventing

Plants," cover page of UIC Health News Source, October 1999.Interview with Sabrina Cornish, UIC News, role of UIC Intellectual Property Office,

February 8, 1999.Interview with Jack Taylor, "Stock Market Observer" (live, channel 26, Chicago), August 4,

1999.Article entitled "Researchers expand search for plants that prevent cancer," cover page of

UIC News, August 25, 1999.Article entitled "UIC attacks cancer's root," cover page of MetroChicago, Chicago Tribune,

Sept. 5, 1999.Article entitled "Planting the Idea," UIC News, Sept. 29, 1999. Article entitled "College of Pharmacy Researchers Seek Cancer Cures in Plants," Medical

Center 1998-1999 Annual Report (UIC).Article entitled "Dividends of Technology," UIC Alumni Magazine, p. 34, January/February

2000.Quoted in abcNEWS.com website article Functional Food, p. 6, June 2000.Interview with Associate Press regarding recent publication on resveratrol mechanism,

June 2000.

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Interview with Gary Robertson, Associated Press, June 29, 2000.Interview with Jenny Hope, Daily Mail, London, August 2, 2000.Appearance on WTTW-TV (Channel 11, PBS) “Chicago Tomorrow,” coverage of cancer

prevention and drug discovery at UIC, appeared on September 26, 2000.Quoted in O – The Oprah Magazine article “Peel me a grape…and pass the olives”, pp.

176-180, September 2001.Appearance on KHBC Radio, July 25, 2007.Appearance on Focus on UH Hilo (cable TV), October 3, 2007.White Coat Ceremony, October 14, 2007.Presentation at Rotary Club of Hilo Bay, October 24, 2007.Attend Walgreen’s Grand Opening, October 30, 2007.Meeting with representative from Senator Akaka and Inouye, various times.Presentation at Kiwanis Club, Hilo, December 21, 2007.Presentation at Rotary Club of Hilo, February 8, 2008.Meetings with ASHP representatives, February 15, 2008.Meeting with Big Island Legislative Delegation, March 6, 2008.Appearance on LAVA 105 and KOA Country Radio, March 10, 2008.Hosted meeting for program project review, Hilo, July 16-17, 2008.Present Grant Rounds at Hilo Medical Center, Sept. 6, 2008.Attend Conducting Internal Investigation Workshop, Oct. 2-3, 2008.White Coat Ceremony, Oct. 12, 2008.Presentation, Rotary Club of Kona, Oct. 14, 2008.Meet with constituents (Longs, Safeway, McKesson), Bay Area, Jan. 12-13, 2009.Host meeting for program project review, San Diego, Jan. 15-16, 2009.Lecture, Pre-Pharmacy Students, Feb. 2, 2009.Lecture on Cancer Chemoprevention, P2 Pharmacy Class, Feb. 3, 2009.Host visitors throughout the year (Target, Walgreens, CVS, etc.)Lecture to UHH Honors Students, Sept. 28, 2010.Appearance on local cable television recognizing Pharmacist Month, Sept. 2010.Appearance on Focus on UH Hilo, Oct. 2010.White Coat Ceremony, Oct.17, 2010.First College of Pharmacy Health Fair, Oct. 18, 2010.Presentation at grand opening, Hawaii Family Practice Medical Center, Oct. 24, 2010. Host and lecture students, Hawaii Preparatory Academy, Oct. 26, 2010.Interviews with C&E News, Nov. 2010.Presentation at Rotary Club of Hilo, Nov. 18, 2010.Presentation, Rotary Club of Kona, Dec. 10, 2010.Presentation, Portuguese Chamber of Commerce, Jan. 26, 2010.College of Pharmacy Faculty Retreat, Feb. 6, 2010.Lecture, Pre-Pharmacy Students, Feb. 8, 2010.Lecture on Cancer Chemoprevention, P2 Pharmacy Class, Feb. 9, 2010.Interview for Kaunānā, Feb. 11, 2010.Host first College of Pharmacy Rubber Slipper Tour, March 5, 2010.Presentation of UH Board of Regents, March 18, 2010.ACPE site visit, March 23-24, 2010.Attend INBRE site visit, UH Manoa, April 7, 2010.Cancer Prevention. From the Deep. Kaunānā 3(1):4-6, 2010 (written by the editor)Scientists Turn to the Ocean to Counter Cancer. Mālamalama 36(1):13, 2011.Local Radio Interview with Denise Laitinen, Feb. 2, 2012.Host EAC for INBRE in Hilo, Feb. 16-17, 2012.Lecture at Big Island Press Club dinner meeting, March 3, 2012.Meet with State Legislators at Capitol, March 28, 2012Meet with Senator Inouye Chief-of-Staff, April 10, 2012Rotary Presentation, April 17, 2012

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Rho Chi Initiation Banquet, April 17, 2012Lecture at Hawaii Pharmacist Association Annual Meeting, April 29, 2012Annual Pharmacy Awards and Recognition Ceremony, May 2, 2012Dean’s luncheon with Pharmacy Graduates, May 10, 2012Banquet with pharmacy graduates and families, May 11, 2012Attend Walgreens symposium, Chicago, Sept. 24-26, 2012.Present lecture at College Career Fair, Oct. 5, 2012.Present lecture at White Coat Ceremony, Oct. 14, 2012.Present lecture at retirement celebration for Dean David Slatkin, Chicago, Oct. 18, 2012.Present lecture at Rotary Club, Nov. 6, 2012.Consult with University of Plymouth, Plymouth, UK, Dec. 9, 2012.Conduct faculty retreat, Feb. 15-16, 2013.Presentation to Hawaii County Council, Feb. 19, 2013.Radio interview with Sherry Bracken, Feb. 21, 2013.Present lecture Japanese Chamber of Commerce, March 19, 2013.Meet with Lieutenant Governor, April 4, 2013.

Purdue University College of Pharmacy, Nursing, and Health Sciences Activities

School activities: Faculty advisor, Student National Pharmaceutical Association (SNPhA)Chair, School of Pharmacy Executive Advisory Committee, 2002-2006Chair, College of Pharmacy, Nursing, and Health Sciences Executive Advisory

Committee, 2002-2006Chair, College of Pharmacy, Nursing, and Health Sciences Area Promotions Committee,

2002-2006

School publications: The Purdue Pharmacist, “Dean’s Desk”

Volume 79, No. 2, Spring 2003Volume 79, No. 3, Summer 2003Volume 79, No. 4, Fall 2003Volume 80, No. 1, Winter 2004

The Purdue Pharmacist, “From the Dean”Volume 80, No. 2, Spring 2004Volume 80, No. 3, Summer 2004Volume 80, No. 4, Fall 2004Volume 81, No. 1, Winter 2005Volume 81, No. 2, Spring 2005Volume 81, No. 3, Summer 2005Volume 81, No. 4, Fall 2005Volume 82, No. 1, Winter 2006Volume 82, No. 2, Spring 2006

Purdue University, School of Pharmacy and Pharmaceutical Sciences, Annual Report. “Report from the Dean.” 2002, 2003, 2004, 2005.

University memberships: Member, Purdue University Promotions Committee, Panels A and X, 2002-2006Member, Purdue University Computing Research Institute Executive Committee, 2002-

2006Member, Purdue University Council of Academic Officers, September 2002-2006

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Member, Purdue University Cancer Center Executive Committee, September 2002-2006Member, Purdue University Cancer Center Liaison Committee, September 2002-2006Member, Purdue University Commencement Platform Party, September 2002-2006Member, Policy Board Meeting for the Purdue University Center on Aging and the Life

CourseChair, Purdue University Cancer Center Director Search Committee, November 2004-

2006

Other memberships: Member of Rite Aid Dean Advisory Council, November 2002-2004Member, Pharmacy Dean’s Research Group, 2002-2006

Teaching: Dean’s Pharmacy Executive Forum (academic elective, PHPR 490D, 1-hour credit

course, offered on Fridays during the academic year), Spring 2002-03, Fall 2003-04, Spring 2003-04, Fall 2004-05, Spring 2005-06

University of Hawaii at Hilo, College of Pharmacy Activities

In the UHH system, Deans of colleges report to the Vice Chancellor of Academic Affairs who in turn reports to the Chancellor. In addition, Deans frequently interact with the Chancellor at various events throughout the year. The College of Pharmacy functions as an autonomous unit within the system, with the Dean serving as the chief academic officer, and being responsible for many functions including: establishment of a pre-pharmacy curriculum for implementation throughout the system; development of the plan to develop and secure approval for implementation of the founding class of PharmD students; acquiring pre-candidate status with the ACPE, and regional accreditation with WASC; prepare and secure approval of annual budgets and start-up funds; development of plans for a new pharmacy building; obtain approval and recruit the administrative team for the UHH-CoP; continue with recruitment of faculty members for the UHH-CoP; secure affiliation agreements with key health systems and pharmacies to provide clinical instruction and shared faculty positions; prepare annual applications for Federal funding; organize and implement outreach programs for various stakeholders in the pharmacy program; develop and implement a fund raising program; nurture relationships with potential donors; secure funding from the State, Federal, Corporate and private sectors; serve as a primary advocate for the College; represent the College in the internal and external environment; create and foster a positive environment for faculty, staff, and students; provide leadership and financial plans to meet the goals of the College; lead the College in obtaining and maintaining ACPE accreditation; serve as lead facilitator for academic, curricular, and research programs; develop and maintain excellence in instruction and research programs through recruitment and retention of high caliber faculty; facilitate and develop the adoption of best and promising curricular instructional delivery, and research practices; personally engage in scholarly activity; support professional development of faculty and staff; provide leadership and support for initiatives that foster the dissemination of knowledge; provide leadership, direction and support in implementing vision, mission, strategic plan, and commitments of the College; in collaboration with faculty and higher administration, develop, coordinate, and achieve short- and long-term goals of the College, University and System; ensure effective services to students; provide budgetary administration and leadership; ensure the administration and operations of the College reflect the diversity of the stakeholders’ cultures and thinking; initiate and support the development of sustained academic partnerships and collaborations; foster alumni moral and include alumni in strategic planning; foster networking and career services for students and alumni; serve as the primary advocate with various legislators; coordinate activities with international organizations to further promote the

31

reputation of the College; encourage and support faculty and staff in the area of grant development; secure funding from various sources; collaborate with the UH Foundation; ensure the development of credit and non-credit programs to serve the needs of constituencies.

Supervision of Research Personnel

Ph.D. Graduate Students:

Dr. D.D. McPherson, 1982-1987 (Dissertation title: Studies on Caesalpinia pulcherrima and DNA-Ligand Interactions).

Dr. C.Y. Duh, 1983-1986 (Dissertation title: Phytochemical and Mechanistic Studies on the Constituents of Wikstroemia elliptica and Stizophyllum riparium).

Dr. T.A. Ratko, 1983-1985 (Dissertation title: Estrous Cycle Modification of Mammary Tumor Induction by N-Methyl-N-nitrosourea).

Dr. S.M. Wong, 1983-1986 (Dissertation title: Studies on Antitumor and Antifertility Plants).Dr. Y. Chang, 1983-1989 (Dissertation title: Chemical and Pharmacological Studies of

Panax quinquefolius and Panax ginseng).Dr. S.M. Swanson, 1984-1989 (Dissertation title: Retinoid Modulation of Benzo(a)pyrene

Metabolism in Cultured Bronchial Epithelium and Effect on cAMP).Dr. W. Mar, 1986-1992 (Dissertation title: Models for the Detection of DNA-Binding

Compounds and Chemopreventive Agents).Ms. S. Bhamarapravati, 1988-1990Ms. M. Arroyo, 1990Dr. G.T. Tan, 1988-1992 (Dissertation title: Natural Product Inhibitors of Human

Immunodeficiency Virus Reverse Transcriptases).Dr. T. Pengsuparp, 1991-1995 (Dissertation title: Antimitotic and Anti-HIV Reverse

Transcriptase Mechanisms Mediated by Natural and Synthetic Compounds).Dr. N. Suh, 1991-1995 (Dissertation title: Use of HL-60 Cell Differentiation for the

Discovery and Characterization of Cancer Chemopreventive Agents).Dr. M. You, 1991-1995 (Dissertation title: Evaluation of Novel Agents that Reverse

Multidrug Resistance and Mediate Cancer Chemoprevention).Dr. L.A. Shamon, 1992-1997 (Dissertation title: Naturally-Occurring Antimutagens and

Inhibitors of Her-1/Neu).Dr. S.K. Lee, 1993-1997 (Dissertation title: Evaluation of Cancer Chemopreventive Activity

Mediated by Antioxidants and Modulators of Tumor Promotion).Dr. E. Pisha, 1991-1998 (Dissertation title: Discovery and Mechanism of Betulinic Acid and

Natural Product Estrogens and Antiestrogens).Dr. M. Jang, 1993-1998 (Dissertation title: Characterization of Cyclooxygenase Inhibitors

as Cancer Chemopreventive Agents). Dr. E. Mata-Greenwood, 1994-2000 (Dissertation title: Natural Inducers of Leukemic Cell

Differentiation: Proliferation Arrest, Differentiation and Cell Death Induced by Brusatol).

Dr. L. Song, 1993-2000 (Dissertation title: Discovery and Mechanistic Evaluation of Early Stage Cancer Chemopreventive Agents).

Dr. Q. Mi, 1996-2001 (Dissertation title: Reversal of Multidrug-Resistance and Evaluation of Anticancer Drugs Employing In Vivo Hollow Fiber Tests).

Dr. K. Bhat, 1997-2001 (Dissertation title: Characterization of Resveratrol and Antiestrogenic Chemopreventive Agents from Plants).

Ms. S. Kim, 2001-2002. Dr. P.A. Tamez, 1998-2003 (Dissertation title: Antimalarial Drug Discovery and

Characterization with DNA Microarrays; Supported by a fellowship from the American Foundation for Pharmaceutical Education, 1999-2003).

Dr. J. Gills, 1997-2003 (Dissertation title: Chemotherapeutic Potential of Deguelin and

32

Evaluation of New Agents for Skin Cancer Chemoprevention, Supported by a fellowship from the American Foundation for Pharmaceutical Education, 1999-2001).

Dr. Y.M. Tan, 1999-2003 (Dissertation title: Signaling Mechanisms Involved in Betulinic Acid Induced Apoptosis in Human Melanoma Cells).

Ms. T. Ogas, 2011-2013.

M.S. Graduate Student:

Ms. H.-S. Park, 2001-2003 (Dissertation title: Aromatase Inhibitors as Breast Cancer Preventive Agents).

Undergraduate Students:

Ms. A. Lewandowski, 1982; Ms. T. Han, 1983; Ms. T. Dontas, 1984, 1985; Ms. A. Gonzales, 1986; Ms. D. Flagge, 1987; Mr. R. Anderson, 1987; Ms. J. Lazar, 1988-1989; Ms. L. Lenzi, 1988-1989; Mr. D. Joyce, 1989; Mr. M. Pacini, 1989; Ms. T. Fong, 1989; Ms. P. Megremis, 1989; Mr. J. Hendon, 1990; Mr. J. Kadic, 1990; Mr. M. Chou, 1992, 1993; Ms. T. Smith, 1993; Ms. C. Chen, 1993; Ms. H. Western, 1994; Ms. V. Mategrano (Honors College), 1996; Ms. M. Tanzi (Honors College), 1996; Mr. O.C. Kennedy (Honors College), 1997; Mr. C.M. Kutza, 1998; Ms. Johanna Heske (University of Munich), 1998-1999; Mr. S. Rooney (Dept. Chemistry, UIC), 1999; Mr. Daniel Appledorn (Biology Department, Kalamazoo College) 1999; Ms. Nidhi Gupta, 2000; Ms. Niloofar Ghazizadeh, 2000; Ms. Patricia Brillo, 2000; Mr. Joshua Henry, 2004-2006, Ms. Melanie Baldonado, 2004-2006, Ms. Dayna Wong, 2009 (many at UH Hilo).

Urban Health-Pharmacy Summer Research Apprentice Program:

Ms. A. Reynolds, 1987; Ms. S. Robles, 1989; Mr. J. Miller, 1991.

Pharmacy Student Advisees:

Ms. M. Bailey (Class of 1993); Ms. P. Bozek (Class of 1993); Ms. P. Aramwit (Class of 1995); Ms. D.J. Keuogh (Class of 1996).

Off-site Student Advisees:

Ms. Liz Sanchez and Ms. Maritza Nieves, University of Puerto Rico.

Visiting Scholars:

Dr. K. Adesogan, University of Ibadan, Nigeria, Nov.-Dec., 1983.Dr. J.-X. Jiang, Kunming Medical College, People's Republic of China, Jan.-Dec., 1983.Dr. Z.-M. Lin, Shanghai Institute of Planned Parenthood Research, People's Republic of

China, March-May, 1983.Dr. X.-D. Fang, Shanghai College of Traditional Chinese Medicine, People's Republic of

China, 1981-1983 (program co-preceptor).Dr. Z. Guo, Gansu Chinese Medicinal Hospital, People's Republic of China, 1984-1985.Dr. H. Zhang, Kunming Institute of Zoology, People's Republic of China, 1986-1987.Ms. M.L. Villareal, Mexican Institute of Social Security, Xochitepec, Mexico, June-August,

1991.

33

Dr. R. Pereda-Miranda, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, October 1991-January 1992.

Dr. Y.H. Moon, Chosum University, Kwangju, South Korea, January 1993-June 1993.Ms. Le Mai Huong, Institute of Natural Products Chemistry, National Center for Natural

Science and Technology, Hanoi, Vietnam, December 1994-May 1995; 1998.Dr. Pedro Chavez, University of Puerto Rico, January 1995.Dr. Muney Serit, University of Malaysia Sarawak, March 1995.Dr. Hang Woo Lee, Genetic Engineering Research Institute, KIST, Yusong, Korea, April

1995-1997.Mr. Javier Taboada, Instituto de Quimica, Universidad Nacional Autonoma de Mexico,

August 1995.Dr. Qing Xu, Department of Pharmacology, Guilin Medical College, Guilin, Guangxi,

China, April-October 1996.Ms. Maria del Carmen Gutierrex Coutino, Instituto de Quimica, Universidad Nacional

Autonoma de Mexico, April-November 1996.Ms. Linar Z. Udin, Indonesian Institute of Sciences, Research and Development Centre for

Applied Chemistry, Jakarta, Indonesia, April-July 1996.Dr. Kristin Ingólfsdóttir, Department of Pharmacy, University of Iceland, Reykjavik, Iceland,

March-July 1998.Dr. Kon Joo Lee, Department of Biology, Andong National University, Seoul, Korea,

January-December 1998.Dr. Le Mai Huong, Institute of Biotechnology (IBT), National Centre for Natural Sciences

and Technology (NCST), Hanoi, Vietnam 1998-1999.Dr. Suparp (Kulawee) Sujarit, Mahidol University, 1999.Ms. Thao Thi Do, Institute of Biotechnology (IBT), National Centre for Natural Sciences

and Technology (NCST), Hanoi, Vietnam, 2000-2001.Ms. Hye-Hyun Yoo, Seoul National University, Collage of Pharmacy, Seoul, Korea,

2001.Dr. Yong Sup Lee, Korea Institute of Science and Technology, Seoul, Korea, 2001-2002.Dr. Sonia Jacinto, University of the Philippines, Institute of Biology, Manilla, Philippines,

2002.Ms. Marina Galvez-Peralta, University of Sevilla, Sevilla, Spain, 2002.Dr. Joell Gills, University of Illinois at Chicago, Chicago, IL, 2003.Ms. Thao Thi Do, Institute of Biotechnology (IBT), National Centre for Natural Sciences

and Technology (NCST), Hanoi, Vietnam, 2004.Ms. Sophaphan Intaphueak, Department of Pharmacology, Faculty of Medicine, Chiang

Mai University, Chiang Mai, Thailand, 2004.Dr. Samaisukh Sopasan, Department of Physiology, Faculty of Science, Mahidol

University, Bangkok, Thailand, 2004. Ms. Phanruethai Pailee, Department of Chemistry, Faculty of Science, Mahidol University,

Bangkok, Thailand, 2004-2005.Dr. Thao Thi Do, Institute of Biotechnology (IBT), National Centre for Natural Sciences and

Technology (NCST), Hanoi, Vietnam, 2006.Ms. Denise Endringer, PhD student of Pharmaceutical Sciences. Universidade Federal de

Minas Gerais, UFMG, Belo Horizonte, Brazil, 2005-2007.Mr. Asad Ghufran, Quaid-I-Azam University, Islamabad, Pakistan, Higher Education

Commission Pakistan, 2008.Mr. Mauro Cesar Cafundo de Morais, PhD student, School of Pharmaceutical Sciences.

State University of Sao Paulo, Brazil – UNESP, 2009.Dr. Suaib Luqman, Scientist Gr. IV (1), Central Institute of Medicinal and Aromatic Plants

(CIMAP), (Council of Scientific and Industrial Research), Lucknow, India, 2008-2010.

Dr. Ihsan-ul-Haq, Quaid-I-Azam University, Islamabad, Pakistan, Higher Education Commission Pakistan, 2010.

34

Dr. Samreen Saleem, Quaid-I-Azam University, Islamabad, Pakistan, Higher Education Commission Pakistan, 2012.

Dr. Nadeem Ahmed, Department of Plant Science, Quaid-i-Azam University, Islamabd. Pakistan, Higher Education Commission Pakistan, 2013-2014.

Dr. Parimelazhagan Thangaraj, Department of Botany, Bharathiar University, Coimbatore, India, 2015.

Research Technicians:

Ms. S. Antosiak, 1981-82; Ms. P. Chattopadhyay, 1984; Ms. R. Huang, 1980-82; Ms. D. Houlihan, 1983; Mr. S. Swanson, 1983-1984; Ms. J. Bies, 1984-1985; Ms. I. Rudzinski, 1984-1985; Mr. S. Kudo, 1984-1986; Mr. G. Skorupa, 1986-1987; Ms. M. Kirkish, 1986-1987; Ms. A. Raktabutr, 1988-1989; Ms. M. Van Zant, 1991-1993; Ms. M. Diaz, 1991-1992; Ms. X. Luo, 1992-2002; Ms. M. Doddi, 1992-1993; Ms. F. Kappis, 1993-1995; Ms. P. Kloss, 1993-1994; Ms. Y. Dong, 1995-2001; Ms. E. Lim (1997-2003); Mr. D.D. Lantvit (1997-2003); Mr. M. Alkire (2003-2004); Ms. E. Shalaev (2003-2004); Ms. A. Monroe (2004-2005); Ms. C. Otemham (2003-2006); Ms. K. Wethington (2004-2006); V. Croy (2005-2006); Mr. B. Rostama (2008-2009); Mr. Daniel Tavares (2009-2010); Ms. B. Burns (2010-2011); Ms. L. Marler (2007-2012).

Research Coordinator: Ms. E. Ryan (1993-2011).

Postdoctoral Associates:

Dr. R. Braun, 1984-1987; Dr. Q. Abbasi, 1985-1986; Dr. C. Angerhofer, 1989-1991 (promoted to Assistant Professor); Dr. M. Naghabushan, 1991-1992; Dr. S. Swanson, 1990; Dr. G.T. Tan, 1992-1994; Dr. W. Mar, 1992-1994; Dr. C. Gerhäuser, 1993-1996 (supported by the Alexander von Humboldt Foundation, 1993-1994); Dr. A. Rimando, 1994-1995; Dr. H. Mehdi, 1994-1997 (Research Assistant Professor); Dr. W. Qing, 1996-1997; Dr. C. Andersson Dunstan, 1997; Dr. H.J. Jeong, 1996-1998; Dr. S.K. Lee, 1997-1999; Dr. S. Gafner, 1998-1999; Dr. Z. Aydogmus, 2000-2002; Dr. E.J. Park, 1999-2002; Dr. H. Chai, 1990-2003 (Research Assistant Professor); Dr. G.T. Tan, 1997-2003 (Research Assistant Professor); Dr. J.W. Kosmeder, 1998-2002 (Research Assistant Professor); Dr. M. Cuendet, 1999-2003; Dr. Y.-H. Kang, 2002-2003; Dr. C. Ma, 2002-2003; Dr. M. Cuendet, 2005-2006; Dr. J. Guilford, 2007-2008; Dr. E.-J. Park, 2008-present; Dr. T. Kondratyuk, 2003-present.

Extramural Funding

Funded (Previous)

"Evaluation of a Novel Tumor Inhibitor: Fagaronine," Children's Memorial Hospital, Chicago. March 1981-August 1982. Principal Investigator, $14,000.

"Assessment of Genetic Toxicity Mediated by Steviol." R03 DE06678 National Institute of Dental Research, NIH. Jan. 1984-June 1985. Principal Investigator, first year budget, $14,932.

"Plant Antitumor Agents: Isolation and Evaluation." R0l CA33047 National Cancer Institute, NIH. July 1983-June 1986. Co-Principal Investigator, first year budget $62,440; second year budget, $66,785; third year budget, $70,647.

"Research Trends in Surgical Oncology." Program Project, Tapas K. Das Gupta (Project

35

Leader). P01 CA31827 National Cancer Institute, NIH. May 1984-April 1988. First year budget, $402,346, second year budget, $429,215, third year budget, $422,000. Project title, "Retinoid Effect on Benzo(a)pyrene-Treated Human Bronchi," Principal Investigator, first year budget, $27,833, second year budget, $29,391, third year budget, $29,078. Project title, "Studies on Estrogen and NMU Synergism in Carcinogenesis," Co-Investigator, first year budget, $47,209, second year budget, $44,225, third year budget, $43,026.

"Studies Involving Ligand-Macromolecule Interactions." K04 CA00982 Research Career Development Award, National Cancer Institute, NIH. July 1984-June 1989.

Institutional Research Grant. American Cancer Society. 1984-1986. Member, Institutional Review Committee, $60,000.

U.S.-Pakistan Cooperative Science Program, National Science Foundation. Development of In Vitro Bioassay Techniques. Joint proposal in collaboration with Professor Atta-ur-Rahman, University of Karachi, Jan. 1986, Travel Award of $2,700.

"Novel Approaches to the Isolation and Purification of Anticancer Agents from Natural Sources." Small Business Innovation Research Program, NIH. Oct. 1986-March 1987. Principal Investigator (UIC Component), $51,366.

"Biomolecular Analysis by Very High Field NMR." DRR-BRS Shared Instrument Grant, NIH. Co-Investigator, $300,000.

"Replacement Mass Spectrometer." DRR-BRS Shared Instrumentation Grant, NIH. Co-Investigator, $245,750.

"Studies on Estrogen and NMU Synergism in Carcinogenesis." R01 CA45355 National Cancer Institute, NIH. July 1987-June 1990. Co-Investigator, first year budget, $66,967, second year budget, $66,163, third year budget, $68,809.

"Small Instrument Program." 1S15CA51331 National Cancer Institute, NIH. Sept. 1989-Aug. 1990. Principal Investigator, one time request for a photodiode array detector, $5,402.

"Purity and Stability of Natural Product Feed Constituents" IIT Research Institute. Jan. 1990-Dec. 1990. Principal Investigator, $26,000.

"New Bioassays for the Characterization and Discovery of Immunostimulatory Natural Products." Alexander von Humboldt Foundation, Federal Republic of Germany. Recipient of fellowship, 1990-1991.

"Evaluation of Plants Used in Traditional Medicine for Potential Anti-AIDS Agents" World Health Organization. May 1989-April 1990. Co-Investigator, $53,000.

"Literature Surveillance for Natural Products with Potential Anti-AIDS Activity." NCI-NO1-CM87226-53, National Cancer Institute, NIH. June 1988-June 1991. Co-Investigator, first year budget, $95,541, second year budget, $100,318.

"Plant Antitumor Agents: Isolation and Identification." R01 CA33047, National Cancer Institute, NIH. Dec. 1988-Nov. 1991. Co-Investigator, first year budget, $92,316; second year budget, $83,100; third year budget, $85,042.

36

"Master Agreement for Clinical Evaluation of Fruit- and Vegetable-Based Experimental Food Supplements." Contract No. N01-CN-05291-01 "Clinical Evaluation of Fortified Foods," National Cancer Institute, NIH. Sept. 1990-Aug. 1991. Co-Investigator, first year budget, $221,841.

"Thai Medicinal Plants Possessing Antimalarial Activity." Grants Program of Tsumura Juntendo, Inc. Jan. 1988-Dec. 1990. Co-Investigator, first year budget, $25,000, second year budget, $25,000.

"Anticancer Plant Principles." R01 CA20164 National Cancer Institute, NIH. Sept. 1985-April 1990. Co-Principal Investigator, first year budget, $65,189, second year budget, $95,631, third year budget, $99,862, fourth year budget, $100,533, fifth year budget, $123,584, sixth year budget, $113,010.

"Acquisition of an Electrospray Mass Spectrometer," S10 RR10485, DRR-BRS Shared Instrument Grant, NIH. April 1, 1996. Co-Investigator, $209,104.

"Evaluation of Plant Extracts for Potential to Inhibit Hepatitis B" Shamon Pharmaceuticals, Inc., Sept. 1994-Aug. 1996, $240,000.

"Training Program for Jacqueline Ropivia," NCI-Frederick Cancer Research & Development Center, Jan. 1 1997-Dec. 31, 1997, Technical Preceptor, $35,629.

"Novel Strategies for Plant-Derived Anticancer Agents" (Program Director, A.D. Kinghorn). National Cooperative Drug Discovery Group Proposal UO1 CA52956 National Cancer Institute, NIH, Sept. 1990-Aug. 1995, first year budget, $667,762; second year budget, $670,236; third year budget, 692,099; fourth year budget, $712,033; fifth year budget, $702,901. Project Leader of Program 3, "Biological Evaluation," first year budget, $147,628; second year budget, $112,216; third year budget, $112,269, fourth year budget, $116,047; fifth year budget, $120,048.

"Natural Inhibitors of Carcinogenesis." Program Project P01 CA48112 National Cancer Institute, NIH, Sept. 1991 to Aug. 1994, first year budget, $649,577; second year budget, $576,459; third year budget, $599,970. Program Director/Principal Investigator.

Competitive renewal of "Natural Inhibitors of Carcinogenesis." Program Project P0l CA48112 National Cancer Institute, NIH, Sept. 1994 to June 1998, fourth year budget, $495,995; fifth year budget, $532,330; sixth year budget, $551,191; seventh year budget, $570,807. Program Director/Principal Investigator.

"Natural Inhibitors of Carcinogenesis" supplement under "Research Supplements for Underrepresented Minorities" for the support of Dr. George O. Udeani, Program Project PO1 CA48112 National Cancer Institute, NIH, Dec. 1994-Aug. 1998, first year budget, $41,666; second year budget, $50,000; third year budget, $50,000.

"Training Grant in Surgical Oncology" National Institutes of Health, Preceptor, April 1990-March 1995, annual budget, $65,000 (Program Director, T.K. Das Gupta).

"Medicinal Uses of Plants Native to the Cuc Phuong National Park (Vietnam)" John D. and Catherine T. MacArthur Foundation, World Environment and Resources Program, $270,000 during the period 1994-1996. Co-Investigator.

"Breast Cancer Research Training Program" U.S. Army Medical Research Acquisition Activity, Preceptor, Sept. 1994-Sept. 1997, $320,000 (Program Director, T.K. Das Gupta).

37

"In vitro Prescreening of Potential Chemopreventive Agents Using Biochemical Markers of the Carcinogenic Process," Workstatement #44, N01-CN-55136 National Cancer Institute, NIH, Oct. 1, 1995-March 31, 1997, $172,203 (total costs), Principal Investigator.

"Collaborative Studies on Potential Bioactive Terrestrial Natural Products of Siberut Island (Sumatera, Indonesia) for their Sustainable Utilization and Conservation" John D. and Catherine T. MacArthur Foundation, World Environment and Resources Program, subcontract for $31,000 during the period 1995-1998. Co-Investigator.

Administrative Supplement for "Natural Inhibitors of Carcinogenesis." Program Project P0l CA48112 National Cancer Institute, NIH, June 1998-April 1999, $57,273. Program Director/Principal Investigator.

In Vitro PreScreening of Various Classes of Chemopreventive Agents Using Rapid Mechanism-based Assays" (Workstatement 57), N01-CN-75006-63 National Cancer Institute, NIH, Oct. 1, 1997-April 30, 1999, $220,454 (total costs), Principal Investigator.

"Chemoprevention of Carcinogen-Induced Lung Tumors by Carotenoids, DHEA and Sulindac in Strain A Mice," Workstatement #53 N01-CN-55164, National Cancer Institute, NIH, Sept. 30, 1995-Sept. 29, 1999, $266,602 (total costs), Principal Investigator.

"In Vitro PreScreening of Various Classes of Chemopreventive Agents Using Rapid Mechanism-based Assays," Workstatement #57, N01-CN-75119 National Cancer Institute, NIH, July 1, 1997-Dec. 31, 1999, $220,454 (total costs), Principal Investigator.

"Chemopreventive Studies Employing a Transgenic Mouse Model Which Yields Prostate Tumors in Male Mice and Breast Tumors in Female Mice," Workstatement #52 N01-CN-55152, National Cancer Institute, NIH, Sept. 30, 1995-Sept. 29, 1999, $248,998 (total costs), Principal Investigator.

Monsanto Life Sciences, support for industrial liaison with faculty position held at UIC, April 1, 1999-March 30, 2000. Principal Investigator, $60,000.

"Acquisition of a 400 MHz NMR Spectrometer," S10 RR11283, DRR-BRS Shared Instrument Grant, NIH. Co-Investigator, $246,500.

Supplement for "Novel Strategies for Plant-Derived Anticancer Agents." National Cooperative Drug Discovery Group Proposal U19 CA52956 National Cancer Institute, NIH, Nov. 1999-Oct. 2000, $20,000, Sept. 1998-Aug. 2000, Principal Investigator (for supplement).

Administrative Supplement for International Cooperative Biodiversity Group "Studies on Biodiversity of Vietnam and Laos." Fogarty International Center, NIH, Oct. 1, 1998-Sept. 30, 1999, $35,000. Principal Investigator (for supplement).

Monsanto Life Sciences, support for industrial liaison with faculty position held at UIC, April 1, 2000-March 30, 2001. Principal Investigator, $37,500.

"Evaluation of the Cancer Chemoprevention Potential of Standardized Grape Extract." California Table Grape Commission. Principal Investigator, $25,000, May 1, 2000-April 30, 2001. Principal Investigator, July 1, 2000-June 30, 2001.

“Synthesis of 4’-Bromoflavone.” McKesson BioServices Corporation. Co-Investigator,

38

$20,737, September 1, 2000-August 31, 2001.

Competitive renewal of "Novel Strategies for Plant-Derived Anticancer Agents." National Cooperative Drug Discovery Group Proposal U19 CA52956 National Cancer Institute, NIH, Sept. 1995-Aug. 2000, first year budget, $566,449; second year budget, $577,322; third year budget $732,607; fourth year budget, $625,857; fifth year budget, $650,892. Project Leader of Program 3, "Biological Evaluation," first year budget, $89,958; second year budget, $91,924; third year budget $103,641; fourth year budget, $99,655; fifth year budget, $103,641.

"Carcinogenic Metabolites Formed from Antiestrogens." National Cancer Institute, NIH. Co-Investigator, first year budget, $143,301 second year budget, $128,971, Dec. 1998-Nov. 2002.

“Center on Botanical Dietary Supplements for Women’s Health,” P50 AT 00155, National Institutes of Health/National Center for Complementary and Alternative Medicine, September 30, 1999-July 31, 2004, first year budget $1,490,487, second year budget $1,517,226 (total costs), Co-Investigator.

International Cooperative Biodiversity Group "Studies on Biodiversity of Vietnam and Laos." Fogarty International Center, NIH, Oct. 1, 1998-Sept. 30, 2003, first year total budget, $470,000; second year total budget $514,000. Project Leader of Project 3, first year budget, $150,000; second year budget, $162,750.

"Screening of Various Chemopreventive Agents in the MNU-Induced Rat Mammary Tumor Model (WS #73)." National Institutes of Health/National Cancer Institute, Principal Investigator, $180,293 (total), September 30, 2000-September 29, 2002. (No-cost extension to December 31, 2003).

"Chemoprevention Screening Employing a Transgenic Mouse Model which Yields Prostate Tumors in Male Mice and Breast Tumors in Female Mice (WS #79)." National Institutes of Health/National Cancer Institute, Principal Investigator, $240,956 (total), September 30, 2000-September 29, 2002. (No-cost extension to December 31, 2003).

"Biological Activity of Natural Proanthocyanidin Mixtures." R21 AT 00404 National Institutes of Health/National Center for Complementary and Alternative Medicine, first year budget $125,000, February 1, 2001-January 31, 2003 (No-cost extension), Co-Investigator.

“Effects of Various Chemopreventive Agents on MNU-Induced Rat Mammary Tumors and Collection of Tumor and Normal Tissues from Rodents Treated with Chemopreventive Agents (WS #80).” National Institutes of Health/National Cancer Institute, Principal Investigator, $319,923 (total), January 1, 2002-March 29, 2006.

“Screening for Chemopreventive Agents in the N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine [OH BBN] Model of Bladder Carcinogenesis (WS #85).” National Institutes of Health/National Cancer Institute, Principal Investigator, $259,492 (total), January 1, 2002-September 29, 2006.

International Cooperative Biodiversity Group "Studies on Biodiversity of Vietnam and Laos." Fogarty International Center, NIH, ninth year budget (05/01/07-04/30/08), $60,010 (DC), $83,054 (TC). No cost extension to 01/31/09.

Co-Investigator (R. Tseng, PI), U.S. Department of Education “Applied Rural Science and

39

Clinical Pharmacy Training Program at the University of Hawaii at Hilo”, $766,373, 07/01/08-06/30/09 (no-cost extension to 06/30/10).

Co-investigator (Chang, PI) The CRCH (Cancer Research Center of Hawaii) Developmental Fund “Screening New Cancer Chemotherapertic Agents from Marine Cyanobacteria”, $36,769 (direct costs), 7/1/08-12/31/09.

Competitive renewal of "Natural Inhibitors of Carcinogenesis." Program Project P0l CA48112 National Cancer Institute, NIH, April 15, 2005 to March 31, 2010 (Years 13-17, DC $5,549,857, TC $6,715,383) – Year 13 (04/15/05-03/31/06) $1,069,175 (DC), $1,314,629 (TC)Year 14 (04/01/06-03/31/07) $1,072,276 (DC), $1,292,922 (TC)Year 15 (04/01/07-03/31/08) $1,201,155 (DC), $1,330,426 (TC)Year 16 (04/01/08-03/31/09) $1,213,009 (DC), $1,329,192 (TC)Year 17 (04/01/09-03/31/10) $1,113,002 (DC), $1,341,115 (TC) (no-cost extension to 03/31/12)

Principal Investigator, ARRA Administrative Supplements (NOT-OD-09-056), National Cancer Institute/NIH, “Natural Inhibitors of Carcinogenesis,” Program Project P01 CA048112, $445,947 (direct costs), $477,847 (total costs), 08/01/09-07/31/10 (no-cost extension to 06/30/11).

Principal Investigator, U.S. Department of Education “Applied Rural Science and Clinical Pharmacy Training Program at the University of Hawaii at Hilo”, $951,000, 09/01/09-08/31/10 (no-cost extension to 08/31/11).

Principal Investigator “Natural Products in the Prevention of Cancer” National Institutes of Health, R13 CA159733, $5,000 (conference grant).

Principal Investigator, U.S. Department of Education “FY 2010: Clinical Pharmacy Training Program”, $1,500,000, 09/01/10-08/31/13.

Hilo Core Director, INBRE II: Hawaii Statewide Research and Education Partnership, National Center for Research Resources (NCRR), NIH, UHH component, ca. $840,000/year plus $225,000 the first year for renovations.

Hilo Core Director, INBRE III: Hawaii Statewide Research and Education Partnership, National Center for Research Resources (NCRR), NIH, UHH component, ca. $820,000/year plus $85,000 the first year for renovations, 4/01/13-3/31/18.

Co-Investigator, NIH R25 RISE minority research training grant, total budget of about $2.4 million (UH Hilo, $760,000).

Funded (Currently Active at LIU)

Principal Investigator, Health and longevity promoted by the consumption of grapes. California Table Grape Commission, $1,200,000, 01/01/19-12/31/23.

Funding (Submitted/in Preparation)

Applications are currently under development for core resources and additional research projects ("Cancer Chemopreventive Potential of Highly Efficacious Derivatives of Resveratrol”; “Synthesis and Evaluation of Novel Anticancer Rexinoids”)

40

Master Agreements

Master Agreement RFA No. NCI-CN-25414-33 , "Evaluation of Chemopreventive Agents by In Vitro Techniques", National Cancer Institute.

Master Agreement RFA No. NCI-CN-25418-51, "Preclinical Evaluation of Intermediate Endpoints and their Modulation by Chemopreventive Agents", National Cancer Institute.

Gifts Provided to Support Research Initiatives

1993-1994

Industrial Technology Research Institute, Union Chemical Laboratories, Hsinchu, Taiwan, $20,000.

Kellogg's, Science and Technology Center, Battle Creek, MI, $28,000.

Shaman Pharmaceutical, South San Francisco, CA, $5,000.

1995-1996

Steroids, Ltd., Chicago, IL, $4,000.

MediChem, Chicago, IL, $13,500.

1999

NaPro Biotherapeutics, Denver, CO, $10,000.

2000

California Table Grape Commission, Fresno, CA, $25,000.

2001

NaPro Biotherapeutics, Denver, CO, $10,000.

Intramural Funding

1981 "Natural Inhibitors of Chemical Carcinogenesis," University of Illinois Medical Center, BRSG. Feb. 1981-March 1982, $1,000.

1982 "HPLC Radiochemical Flow Detector." University of Illinois Medical Center Graduate College. Co-Principal Investigator, one time request, $9,500.

1983 "Plant Antitumor Agents: Evaluation of the Family Moniniaceae." University of Illinois at Chicago Graduate College. Co-Principal Investigator, $1,500.

41

1984 "Application for Funds for the Purchase of a Replacement Ultracentrifuge." Co-Principal Investigator, one time request, $18,525.

"Application for Funds Towards the Purchase of a Replacement Ultraviolet/Visible Spectrophotometer." Co-Principal Investigator, one time request, $7,175.

1986 "Application for Funds Towards the Purchase of a Replacement Scintillation Counter." Co-Principal Investigator, one time request, $7,500.

1990 "Funds Towards the Purchase of a Photodiode Array Detector." Principal Investigator, one time request, $7,966.

1998 "Funds Towards the Purchase of a Microplate Fluorometer." UIC Campus Research Board, Principal Investigator, $7,500.

Interim funding related to the management of Program Project CA48112 "Natural Inhibitors of Carcinogenesis," ca. $65,000, shared between Colleges and Office of the Vice Chancellor for Research, UIC.

Publications

Ph.D. Dissertation

"Studies on the Metabolic Activation of Benzo(a)pyrene and Subsequent Binding to Nuclear Macromolecules," University of Medicine and Dentistry of New Jersey, Newark, New Jersey, 1977.

Articles in print/in press

Pezzuto, J.M., Lea, M.A., and Yang, C.S. Binding of metabolically activated benzo(a)pyrene to nuclear macromolecules. Cancer Res. 36: 3647-3653, 1976.

Pezzuto, J.M., Lea, M.A., and Yang, C.S. The role of microsomes and the nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules. Cancer Res. 37: 3427-3433, 1977.

Pezzuto, J.M., Lea, M.A., and Yang, C.S. Binding of metabolically activated benzo(a)pyrene to DNA and histones of rat liver, lung, and regenerating liver. Life Sci. 22: 105-110, 1978.

Pezzuto, J.M., Yang, C.S., Yang, S.K., McCourt, D.W., and Gelboin, H.V. Metabolism of benzo(a)pyrene and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes. Cancer Res. 38: 1241-1245, 1978.

Alford, B.L., Pezzuto, J.M., Tan, K.H., and Hecht, S.M. Both positional isomers of

aminoacyl-tRNA's are bound by elongation factor Tu. J. Biol. Chem. 254: 6894-6903, 1979.

Pezzuto, J.M. and Hecht, S.M. Amino acid substitutions in protein biosynthesis. Poly A-directed polyphenylalanine synthesis. J. Biol. Chem. 255: 865-869, 1980.

Pezzuto, J.M., Lau, P.P., Luh, Y., Moore, P.D., Wogan, G.N., and Hecht, S.M. There is a correlation between the DNA affinity and mutagenicity of several 3-amino-l-methyl-5H-pyrido(4,3-b)indoles. Proc. Natl. Acad. Sci. USA 77: 1427-1431, 1980.

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Pezzuto, J.M., Moore, P.D., and Hecht, S.M. Metabolic activation of 3-amino-l-methyl-5H-pyrido(4,3-b)indole and several structurally related mutagens. Biochemistry 20: 298-305, 1981.

Pezzuto, J.M., Antosiak, S.K., Messmer, W.M., Slaytor, M.B., and Honig, G.R. Interaction of the antileukemic alkaloid, 2-hydroxy-3,8,9-trimethoxy-5-methylbenzo(c)phenanthridine (Fagaronine), with nucleic acids. Chem.-Biol. Interactions 43: 323-339, 1983.

McPherson, D.D. and Pezzuto, J.M. Interaction of 9-aminoacridine, ethidium bromide and harman with DNA characterized by size exclusion high-performance liquid chromatography. J. Chromatogr. 281: 348-354, 1983.

McPherson, D.D., Cordell, G.A., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. New peltogynoids and homoisoflavonoids from Caesalpinia pulcherrima. Phytochemistry 22: 2835-2838, 1983.

Marcelle, G.B., Ahmed, M.S., Pezzuto, J.M., Cordell, G.A., Waller, D.P., Soejarto, D.D., and Fong, H.H.S. Quantitative analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. J. Pharm. Sci. 73: 396-398, 1984.

Arisawa, M., Pezzuto, J.M., Kinghorn, A.D., Cordell, G.A., and Farnsworth, N.R. Plant anticancer agents. XXX. Cucurbitacins from Ipomopsis aggregata (Polemoniaceae). J. Pharm. Sci. 73: 411-413, 1984.

Arisawa, M., Funayama, S., Pezzuto, J.M., Kinghorn, A.D., Cordell, G.A., and Farnsworth, N.R. Potential anticancer agents. XXXII. Hydroquinone from Ipomopsis aggregata (Polemoniaceae). J. Nat. Prod. 47: 393-394, 1984.

Arisawa, M., Pezzuto, J.M., Bevelle, C., and Cordell, G.A. Potential anticancer agents. XXXI. N-demethylation of fagaronine. J. Nat. Prod. 47: 453-458, 1984.

Fang, X., Phoebe, Jr., C.H., Pezzuto, J.M., Fong, H.H.S., Farnsworth, N.R., Yellin, B., and Hecht, S.M. Plant antitumor agents. XXXIV. Cucurbitacins from Elaeocarpus dilichostylus. J. Nat. Prod. 47: 988-993, 1984.

Guo, J.-X., Handa, S.S., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XXXIII. Constituents of Passerina vulgaris. Planta Med. 50: 264-265, 1984.

Pezzuto, J.M., Swanson, S.M., and Farnsworth, N.R. Evaluation of the mutagenic potential of Endod (Phytolacca dodecandra), a molluscicide of potential value for the control of schistosomiasis. Toxicol. Lett. 22: 15-20, 1984.

Compadre, C.M., Pezzuto, J.M., Kinghorn, A.D., and Kamath, S.K. Hernandulcin: an intensely sweet compound discovered by review of ancient literature. Science 227: 417-419, 1985.

Ratko, T.A. and Pezzuto, J.M. An improved fluorometric method for quantitative high-performance liquid chromatographic analysis of methylated guanine in DNA. J. Chromatogr. 324: 484-488, 1985.

Pezzuto, J.M., Compadre, C.M., Swanson, S.M., Nanayakkara, N.P.D., and Kinghorn, A.D. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc. Natl. Acad. Sci. USA 82: 2478-2482, 1985.

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Wong, S.M., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Isolation, structure elucidation and chemical synthesis of 2-hydroxy-3-octadecyl-5-methoxy-1,4-benzoquinone (Irisoquin), a cytotoxic constituent of Iris missouriensis. J. Pharm. Sci. 74: 1114-1116, 1985.

Fiebig, M., Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLI. Cardiac glycosides from Streblus asper. J. Nat. Prod. 48: 981-985, 1985.

Fiebig, M., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Koenoline, A further cytotoxic carbazole alkaloid from Murraya koenigii. Phytochemistry 24: 3041-3043, 1985.

Fang, X., Nanayakkara, N.P.D., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XXXVII. Constituents of Amanoa oblongifolia. Planta Med., 346-347, 1985.

Pezzuto, J.M., Nanayakkara, N.P.D., Compadre, C.M., Swanson, S.M., Kinghorn, A.D., Guenthner, T.M., Sparnins, V.L., and Lam, L.K.T. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (Steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice. Mutation Res. 169: 93-103, 1986.

McPherson, D.D., Che, C.-T., Cordell, G.A., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Diterpenoids from Caesalpinia pulcherrima. Phytochemistry 25: 167-170, 1986.

Wong, S.-M., Oshima, Y., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Plant anticancer agents. XXXIX. Triterpenes from Iris missouriensis (Iradaceae). J. Pharm. Sci. 75: 317-320, 1986.

Wong, S.-M., Pezzuto, J.M., Fong, H.H.S. and Farnsworth, N.R. Isolation and characterization of a new triterpene from Iris missouriensis. J. Nat. Prod. 49: 330-333, 1986.

Duh, C.-Y., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLII. Cytotoxic constituents from Wikstroemia elliptica. J. Nat. Prod. 49: 706-709, 1986.

Chang, Y.S., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Evaluation of the mutagenic potential of American Ginseng (Panax quinquefolius L.). Planta Med. 338-339, 1986.

Hussain, R.A., Kim, J., Hu, T.-W., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Isolation of a highly sweet constituent from Cinnamonum osmophloeium leaves. Planta Med. 403-404, 1986.

Choi, Y.-H., Kim, J., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., Lotter, H., and Wagner, H. Agrostistachin, a novel cytotoxic macrocyclic diterpene from Agrostistachys hookeri. Tetrahedron Lett. 27: 5795-5798, 1986.

Braun, R.J., Ratko, T.A., Pezzuto, J.M., and Beattie, C.W. Estrous cycle modification of rat uterine DNA alkylation by N-methyl-N-nitrosourea. Cancer Lett. 37: 345-352, 1987.

Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., Leung, S.L., and Farnsworth, N.R. Plant anticancer agents. XLIV. Cytotoxic constituents from Stizophyllum riparium. J. Nat. Prod. 50: 63-74, 1987.

Wong, S.-M., Konno, C., Oshima, Y., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Irisones A and B: two new isoflavones from Iris missouriensis Nutt. (Iridaceae). J. Nat. Prod. 50:

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178-180, 1987.

Nanayakkara, N.P.D., Klocke, J.A., Compadre, C.M., Hussain, R.A., Pezzuto, J.M., and Kinghorn, A.D. Characterization and feeding deterrent effects on the Aphid, Schizaphis graminum, of some derivatives of the sweet compounds, stevioside and rebaudioside A. J. Nat. Prod. 50: 434-441, 1987.

Compadre, C.M., Hussain, R.A., Lopez de Compadre, R.L., Pezzuto, J.M., and Kinghorn, A.D. The intensely sweet sesquiterpene, Hernandulcin: isolation, synthesis, characterization, and preliminary safety evaluation. J. Agric. Food Chem. 35: 273-279, 1987.

Compadre, C.M., Hussain, R.A., Nanayakkara, N.P.D., Pezzuto, J.M., and Kinghorn, A.D. Mass spectral analysis of some derivatives and in vitro metabolites of Steviol, the aglycone of the natural sweeteners, Stevioside, Rebaudioside A, and Rubusoside. Biomed. Environ. Mass Spectrom. 15: 211-222, 1988.

Ratko, T.A., Braun, R.J., Pezzuto, J.M., and Beattie, C.W. Estrous cycle modification of rat mammary gland DNA alkylation by N-methyl-N-nitrosourea. Cancer Res. 48: 3090-3093, 1988.

Compadre, C.M., Hussain, R.A., Lopez de Compadre, R.L., Pezzuto, J.M., and Kinghorn, A.D. Analysis of structural features responsible for the sweetness of the sesquiterpene, Hernandulcin. Experientia 44: 447-449, 1988.

Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLVI. Cytotoxic casbene-type constituents of Agrostistachys hookeri. J. Nat. Prod. 51: 110-116, 1988.

Liu, S.-Q., Pezzuto, J.M., Kinghorn, A.D., and Scheld, H.W. Additional biologically active constituents of the Chinese Tallow Tree (Sapium sebiferum). J. Nat. Prod. 51: 619-620, 1988.

Swanson, S.M., Jiang, J.-X., de Souza, N.J., and Pezzuto, J.M. A rapid and sensitive bioassay involving cultured rat glioma cells to screen for substances capable of elevating intracellular cyclic AMP concentration. J. Nat. Prod. 51: 929-936, 1988.

Kim, J., Pezzuto, J.M., Soejarto, D.D., Lang, F.A., and Kinghorn, A.D. Polypodoside A, an intensely sweet constituent of the rhizomes of Polypodium glycyrrhiza. J. Nat. Prod. 51: 1166-1172, 1988.

Lam, L.K.T., Garg, P.K., Swanson, S.M., and Pezzuto, J.M. Evaluation of the cytotoxic potential of catechols and quinones structurally-related to butylated hydroxyanisole. J. Pharm. Sci. 77: 393-395, 1988.

Nanayakkara, N.P.D., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. An intensely sweet dihydroflavonol derivative based on a natural product lead compound. J. Med. Chem. 31: 1250-1253, 1988.

Pezzuto, J.M., Swanson, S.M., Mar, W., Che, C.-T., Cordell, G.A., and Fong, H.H.S. Evaluation of the mutagenic and cytotoxic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-l0-nitrophenanthrene-l-carboxylic acid) and several derivatives. Mutation Res. 206: 447-454, 1988.

Pezzuto, J.M., Shieh, H.-L., Shaughnessy, E., and Beattie, C.W. Approaches for drug development in treatment of advanced melanoma. Sem. Oncol. 15: 578-588, 1988.

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Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Ellagic acid derivatives of Agrostistachys hookeri. Planta Med. 511-513, 1988.

Bishay, D.W., Che, C.T., Gonzalez, A., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Further chemical constituents of Mitragyna inermis Stem Bark. Fitoterapia 59: 397-398, 1988.

Jayasuriya, H., McChesney, J.D., Swanson, S.M., and Pezzuto, J.M. Antimicrobial and cytotoxic activity of rottlerin-type compounds from Hypericum drummondii. J. Nat. Prod. 52: 325-331, 1989.

Jonathan, L.T., Che, C.-T., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. 7-O-Methylhorminone and other cytotoxic diterpene quinones from Lepechinia bullata. J. Nat. Prod. 52: 571-575, 1989.

Choi, Y.-H., Hussain, R.A., Pezzuto, J.M., Kinghorn, A.S., and Morton, J.F. Abrusosides A-D, four novel sweet-tasting triterpene glycosides from the leaves of Abrus precatorius. J. Nat. Prod. 52: 1118-1127, 1989.

Kigodi, P.G.K., Blaskó, G., Thebtaranonth, Y., Pezzuto, J.M., and Cordell, G.A. A new limonoid from Azadirachta indica. Spectroscopic and biological investigation of nimbolide and 28-deoxynimbolide. J. Nat. Prod. 52: 1246-1251, 1989.

Blaskó, G., Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Carbon-13 spectral assignment and evaluation of the cytotoxic potential of rotenone. J. Nat. Prod. 52: 1363-1366, 1989.

Braun, R.J., Pezzuto, J.M., Anderson, C.H., and Beattie, C.W. Estrous cycle status alters N-methyl-N-nitrosourea (NMU)-induced rat mammary tumor growth and regression. Cancer Lett. 48: 205-211, 1989.

Hamburger, M.O., Shieh, H.-L., Zhou, B.-N., Pezzuto, J.M., and Cordell, G.A. Pseudolaric acid B: NMR assignments, conformational analysis, and cytotoxicity. Magn. Reson. Chem. 27: 1025-1030, 1989.

Bavovada, R., Blaskó, G., Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum. Planta Med. 56: 380-382, 1990.

Hussain, R.A., Lin, L.M., Proveda, L.M., Bordas, E., Chung, B.S., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Plant-derived sweetening agents: saccharide and polyol constituents of some sweet-tasting plants. J. Ethnopharmacol. 28: 103-115, 1990.

Hussain, R.A., Poveda, L.M., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Sweetening agents of plant origin: phenylpropanoid constituents of seven sweet-tasting plants. Econ. Bot. 44: 174-182, 1990.

Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia. J. Nat. Prod. 53: 1447-1455, 1990.

Tan, G.T., Pezzuto, J.M., Kinghorn, A.D., and Hughes, S.H. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J. Nat. Prod. 54: 143-154, 1991.

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Kaneda, N., Pezzuto, J.M., Soejarto, D.D., Kinghorn, A.D., Farnsworth, N.R., Santisuk, T., Tuchinda, P., Udchachon, J., and Reutrakul, V. Plant antitumor agents, XLVIII. New cytotoxic flavonoids from Muntingia calabura roots. J. Nat. Prod. 54: 196-206, 1991.

Ngassapa, O.D., Soejarto, D.D., Che, C.-T., Pezzuto, J.M., and Farnsworth, N.R. New cytotoxic lupane lactones from Kokoona ochracea. J. Nat. Prod. 54: 1353-1359, 1991.

Kardono, L.B.S., Angerhofer, C.K., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia. J. Nat. Prod. 54: 1360-1367, 1991.

Pezzuto, J.M., Che, C.-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A. DNA as an affinity probe useful in the detection and isolation of biologically active natural products. J. Nat. Prod. 54: 1522-1530, 1991.

Mar, W., Tan, G.T., Cordell, G.A., Pezzuto, J.M., Jurcic, K., Redl, K., Steinke, B., and Wagner, H. Biological activity of novel macrocyclic alkaloids (Budmunchiamines) from Albizia amara detected on the basis of interaction with DNA. J. Nat. Prod., 54: 1531-1542, 1991.

Duh, C.-Y., Kinghorn, A.D., and Pezzuto, J.M. Cell cycle specific cytotoxicity mediated by Stizophyllin (2,3,12-trihydroxypregna-4,7,16-trien-20-one), a novel electrophilic pregnane isolated from Stizophyllum riparium. Chem.-Biol. Interactions, 80: 43-56, 1991.

Cordell, G.A., Beecher, C.C.W., and Pezzuto, J.M. Can ethnopharmacology contribute to the development of new anticancer drugs? J. Ethnopharmacol. 32: 117-133, 1991.

Pezzuto, J.M., Mar, W., Lin, L.-Z., Cordell, G.A., Neszmélyi, A., and Wagner, H. DNA-based isolation and the structure elucidation of the budmunchiamines, novel macrocyclic alkaloids from Albizia amara. Heterocycles 32: 1961-1967, 1991.

Fullas, F., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., Kinghorn, A.D., and Bordas, E. Gaudichaudiosides A-E, five novel diterpene glycoside constituents from the sweet-tasting plant, Baccharis gaudichaudiana. Tetrahedron 47: 8515-8522, 1991.

Tan, G.T., Kinghorn, A.D., Hughes, S.H., and Pezzuto, J.M. Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. J. Biol. Chem. 266: 23529-23536, 1991.

Tuchinda, P., Udchachon, J., Reutrakul, V., Santisuk, T., Taylor, W.C., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Bioactive butenolides from Melodorum fruticosum. Phytochemistry 30: 2685-2689, 1991.

Dai, J., Kardono, L.B.S., Tsauri, S., Padmanwinata, K., Pezzuto, J.M., and Kinghorn, A.D. Phenylacetic acid derivatives and a thioamide glycoside from Entada phaseoloides. Phytochemistry 30: 3749-3752, 1991.

Zong, Y.-Y., Lowell, K., Jiang, P., Che, C.-T., Pezzuto, J.M., and Fong, H.H.S. Phenolic constituents of Rhodiola coccinea, a Tibetan folk medicine. Planta Med. 57: 589, 1991.

Kaneda, H., Chai, H., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., Tuchinda, P., Udchachon, J., Santisuk, T., and Reutrakul, V. Cytotoxic activity of cardenolides from Beaumontia brevituba stems. Planta Med. 58: 429-431, 1992.

Pezzuto, J.M., Mar, W., Lin, L.-Z, Cordell, G.A., Neszmélyi, A., and Wagner, H.

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Budmunchiamines D-I from Albizia amara. Phytochemistry 31: 1795-1800, 1992.

Lin, L.-J., Ruangrungsi, N., Cordell, G.A., Shieh, H.-L., You, M., and Pezzuto, J.M. 6-Deoxyclitoriacetal from Clitoria macrophylla. Phytochemistry 31: 4329-4331, 1992.

Lin, L.-J., Topçu, G., Lotter, H., Ruangrungsi, N., Wagner, H., Pezzuto, J.M., and Cordell, G.A. Wrightiadione from Wrightia tomentosa. Phytochemistry 31: 4333-4335, 1992.

Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Evaluation of the cytotoxic mechanism mediated by the broad-spectrum antitumor compound acronycine and semisynthetic derivatives. Chem.-Biol. Interactions 81: 35-55, 1992.

Kaneda, N., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, A.D., Santisuk, T., Tuchinda, P., Udchachon, J., and Reutrakul, V. Plant anticancer agents, L. Cytotoxic triterpenes from Sandoricum koetjape Stems. J. Nat. Prod. 55: 654-659, 1992.

Angerhofer, C.K., Pezzuto, J.M., König, G.M., Wright, A.D., and Sticher, O. Antimalarial sesquiterpenes from the marine sponge, Acanthella klethra. J. Nat. Prod. 55: 1787-1789, 1992.

Tan, G.T., Miller, J., Kinghorn, A.D., Hughes, S.H., and Pezzuto, J.M. HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. Biochem. Biophys. Res. Commun. 185: 370-378, 1992.

Gerhäuser, C., Leonhardt, K., Tan, G.T., Pezzuto, J.M., and Wagner, H. What is the active antiviral principle of Thuja occidentalis L.? Pharm. Pharmacol. Lett. 2: 127-130, 1992.

Tan, G.T., Wickramasinghe, A., Verma, S., Singh, R., Hughes, S.H., Pezzuto, J.M., Baba, M., and Mohan, P. Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1-induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities. J. Med. Chem. 35: 4846-4853, 1992.

Lin, L.-Z., Shieh, H.-L., Angerhofer, C.K., Pezzuto, J.M., Cordell, G.A., Xue, L., Johnson, M.E., and Ruangrungsi, N. Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata. J. Nat. Prod. 56: 22-29, 1993.

Likhitwitayawuid, K., Angerhofer, C.K., Cordell, G.A., Pezzuto, J.M., and Ruangrungsi, N. Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. J. Nat. Prod. 56: 30-38, 1993.

Somanabandhu, A., Nitayangkura, S., Mahidol, C., Ruchirawat, Likhitwitayawuid, K.-S., Shieh, H.-L., Chai, H., Pezzuto, J.M., and Cordell, G.A. 1H- and 13C-NMR assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with multidrug- resistant cells. J. Nat. Prod. 56: 233-239, 1993.

Saifah, E., Likhitwitayawuid, K., Puripattanavong, J., Cordell, G.A., Chai, J., and Pezzuto, J.M. Bisamides from Aglaia Species: structure analysis and potential to reverse drug resistance with cultured cells. J. Nat. Prod. 56: 473-477, 1993.

Pereda-Miranda, R., Mata, R., Anaya, A.L., Pezzuto, J.M., Chai, H., Dias, M., Wickramaratne, M., and Kinghorn, A.D. Tricolorin A, major phytogrowth-inhibitor from Ipomoea tricolor. J. Nat. Prod. 56: 571-582, 1993.

Pereda-Miranda, R., Hernández, L., Villavicencio, M.J., Novelo, M., Ibarra, P., Chai, H., and Pezzuto, J.M. Structure and stereochemistry of Pectinolides A-C, novel antimicrobial and

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cytotoxic 5,6-dihydro--pyrones from Hyptis pectinata. J. Nat. Prod. 56: 583-593, 1993.

Likhitwitayawuid, K., Angerhofer, C.K., Chai, H., Pezzuto, J.M., Cordell, G.A., and Ruangrungsi, N. Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile. J. Nat. Prod. 56: 1331-1338, 1993.

Antoun, M.D., Ríos, Y.R., Mendoza, N.T., Wickramaratne, D.B.N., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxicity of Hymenocallis expansa alkaloids. J. Nat. Prod. 56: 1423-1425, 1993.

Likhitwitayawuid, K., Angerhofer, C.K., Chai, H., Pezzuto, J.M., Cordell, G.A., and Ruangrungsi, N. Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. J. Nat. Prod. 56: 1468-1478, 1993.

Baek, N.-I., Chung, M.-S., Shamon, L., Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Selligueain A, a novel highly sweet proanthocyanidin from the rhizomes of Selliguea feii. J. Nat. Prod. 56: 1532-1538, 1993.

Ngassapa, O.D., Soejarto, D.D., Pezzuto, J.M., Farnsworth, N.R., and Che, C.-T. Further lupane lactones from Kokoona ochracea. J. Nat. Prod. 56: 1676-1681, 1993.

Novelo, M., Cruz, J.G., Hernández, L., Perdea-Miranda, R., Chai, H., Mar, W., and Pezzuto, J.M. Cytotoxic constituents from Hyptis verticillata. J. Nat. Prod. 56: 1728-1736, 1993.

Nsassapa, O., Beecher, C.W.W., Pezzuto, J.M., Farnsworth, N.R., Henderson, T.O., and Boye, G.L. Isolation of echinocystic acid 3-O-sulfate, a new triterpene from Tetrapleura tetraptera, and evaluation of the mutagenic potential of molluscicidal extracts and isolates. J. Nat. Prod. 56: 1872-1877, 1993.

Luyengi, L., Pezzuto, J.M., Waller, D.P., Beecher, C.W.W., Fong, H.H.S., Che, C.-T., and Bowen, P.E. Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum. J. Nat. Prod. 56: 2012-2015, 1993.

Wickramaratne, D.B.M., Pengsuparp, T., Mar, W., Chai, H.-B., Chagwedera, T.E., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., and Cordell, G.A. Novel antimitotic dibenzocyclo-octadiene lignan constituents of the stem bark of Steganotaenia araliacea. J. Nat. Prod. 56: 2083-2090, 1993.

Nshimo, C.M., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic constituents of Muntingia calagura leaves and stems collected in Thailand. Int. J. Pharmacog. 31: 77-81, 1993.

Lin, L.-J., Lin, L.-Z, Pezzuto, J.M., Cordell, G.A., and Ruangrungsi, N. Isogambogic acid and isomorellinol from Garcinia hanburyi. Magn. Reson. Chem. 31: 340-347, 1993.

Tan, G.T., Wickramasinghe, A., Verma, S., Hughes, S.H., Pezzuto, J.M., Baba, M., and Mohan, P. Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2. Biochim. Biophys. Acta 1181: 183-188, 1993.

Topçu, G., Öksüz, S., Shieh, H.-L., Cordell, G.A., Pezzuto, J.M., and Bozok-Johansson, C. Cytotoxic and antibacterial sesquiterpenes from Inula graveolens. Phytochemistry 33: 407-410, 1993.

Afifi, M.S.A., Ahmed, M.M., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic flavonolignan and flavones from Verbascum sinaiticum leaves. Phytochemistry 34: 839-841, 1993.

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Öksüz, S., Shieh, H.-L., Pezzuto, J.M., Özhatay, N., and Cordell, G.A. Biologically active compounds from the Euphorbiaceae. Part 1. Triterpenoids of Euphorphia nicaeensis subsp. glareosa. Planta Med. 59: 472-473, 1993.

Gerhäuser, C., Samtleben, R., Tan, G.T., Pezzuto, J.M., Lottspeich, F., and Wagner, H. Peponin, a new ribosome-inactivating protein isolated from seeds of Cucurbita pepo L. inhibits human immunodeficiency virus type I reverse transcriptase. Pharm. Pharmacol. Lett. 3: 71-75, 1993.

Dai, J.-R., Chai, H., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the roots of the Indonesian medicinal plant Fibraurea chloroleuca. Phytother. Res. 7: 290-294, 1993.

Alkan-Onyuksel, H., Ramakrishnan, S., Chai, H.-B., and Pezzuto, J.M. A mixed micellar formulation suitable for the parenteral administration of Taxol. Pharm. Res. 11: 206-212, 1994.

Wall, M.E., Wani, M.C., Fullas, F., Oswald, J.B., Brown, D.M., Santisuk, T., Reutrakul, V., McPhail, A.T., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., and Besterman, J.M. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. J. Med. Chem. 37: 1465-1470, 1994.

Ngassapa, O., Soejarto, D.D., Pezzuto, J.M., and Farnsworth, N.R. Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea. J. Nat. Prod. 57: 1-8, 1994.

Pengsuparp, T., Cai, L., Fong, H.H.S., Kinghorn, A.D., Pezzuto, J.M., Wani, M.C., and Wall, M.E. Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase. J. Nat. Prod. 57: 415-418, 1994.

Kardono, L.B.S., Tsauri, S., Pezzuto, J.M., Kinghorn, A.D., and Padmawinata, K. Cytotoxic isoflavonoids of Pachyrrhizus erosus seeds. Jurnal Kimia Terapan Indonesia 4: 2-12, 1994.

Fullas, F., Hussain, R.A., Chai, H., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Cytotoxic constituents of Baccharis gauichaudiana. J. Nat. Prod. 57: 801-807, 1994.

Rimando, A.M., Pezzuto, J.M., Farnsworth, N.R., Santisuk, T., Reutrakul, V., and Kawanishi, K. New lignans from Anogeisus acuminata with HIV-1 reverse transcriptase inhibitory activity. J. Nat. Prod. 57: 896-904, 1994.

Chen, I.-S., Wu, S.-Y., Tsai, I.-L., Wu, T.-S., Pezzuto, J.M., Lu, M.C., Chai, H., Suh, N., and Teng, C.-M. Chemical and bioactive constituents from Zanthoxylum simulans. J. Nat. Prod. 57: 1206-1211, 1994.

Sun, H.-D., Lin, Z.-W., Niu, F.-D., Lin, L.-Z., Angerhofer, C.K., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cytotoxic diterpenoids from Isodon megathyrsus. J. Nat. Prod. 57: 1424-1429, 1994.

Lin, L.-Z., Hu, S.-F., Zaw, K., Lin, J., Zheng, D.-M., Angerhofer, C.K., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi. J. Nat. Prod. 57: 1430-1436, 1994.

Rimando, A.M., Pezzuto, J.M., and Farnsworth, N.R. Revision of the NMR assignments of pterostilbene and of dihydrodehydrodiconiferyl alcohol: cytotoxic constituents from Anogeissus acuminata. Nat. Prod. Res. 4: 267-272, 1994.

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Gören, N., Tahtasakal, E., Gil, R.R., Pezzuto, J.M., Cordell, G.A., Schwarz, B., and Proksch, P. Sesquiterpene lactones from Tanacetum argenteum subsp. argenteum. Phytochemistry 36: 389-392, 1994.

Luyengi, L., Lee, I.-S., Mar, W., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Rotenoids and chalcones from Mundulea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity. Phytochemistry 36: 1523-1526, 1994.

Cordell, G.A., Angerhofer, C.K., and Pezzuto, J.M. Recent studies on cytotoxic, anti-HIV and antimalarial agents from plants. Pure & Appl. Chem. 66: 2283-2286, 1994.

Mehta, R.G., Liu, J., Constantinou, A., Hawthorne, M., Pezzuto, J.M., Moon, R.C., and Moriarty, R.M. Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture. Anticancer Res. 14: 1209-1214, 1994.

You, M., Ma, X., Mukherjee, R., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells. J. Nat. Prod., 57: 1517-1522, 1994.

König, G.M., Wright, A.D., Sticher, O., Angerhofer, C.K., and Pezzuto, J.M. Biological activities of selected marine natural products. Planta Med., 60: 532-537, 1994.

Öksüz, S., Gil, R.R., Chai, H., Pezzuto, J.M., Cordell, G.A., and Ulubelen, A. Biologically active compounds from the Euphorbiaceae. Part 2. Triterpenoids for Euphorbia cyparissias. Planta Med., 60: 594-596, 1994.

Shamon, L.A., Chen, C., Mehta, R.G., Steele, V., Moon, R.C., and Pezzuto, J.M. A correlative approach for the discovery of antimutagens that demonstrate cancer chemopreventive activity. Anticancer Res., 14: 1775-1778, 1994.

Ma, X., Lee, I.-S., Chai, H.-B., Zaw, K., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic clerodane diterpenes from Polyalthia barnesii. Phytochemistry, 37: 1659-1662, 1994.

Mehta, R.G., Liu, J., Constantinou, A., Thomas, C.F., Hawthorne, M., You, M., Gerhäuser, C., Pezzuto, J.M., Moon, R.C., and Moriarty, R.M. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis, 16: 399-404, 1995.

Sun, H.-D., Lin, Z.-W., Niu, F.D., Lin, L.-Z., Chai, H.B., Pezzuto, J.M., and Cordell, G.A. Cytotoxic ent-kaurene diterpenoids from three Isodon species. Phytochemistry, 38: 437-442, 1995.

Lee, I.-S., Ma, X., Chai, H.-B., Madulid, D.A., Lamont, R.B., O'Neill, M.J., Besterman, J.M., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic labdane diterpenoids for Neouvaria acuminatissima. Tetrahedron, 51: 21-28, 1995.

Wickramaratne, D.B.M., Mar, W., Chai, H., Castillo, J.J., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of Bursera permollis. Planta Med., 61: 80-81, 1995.

Gerhäuser, C., Mar, W., Lee, S.K., Suh, N., Luo, Y., Kosmeder, J., Moriarty, R.M., Luyengi, L., Kinghorn, A.D., Fong, H.H.S., Mehta, R.G., Constantinou, A., Moon, R.C., and Pezzuto, J.M. Rotenoids mediate potent chemopreventive activity through transcriptional

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regulation of ornithine decarboxylase. Nature Medicine, 1: 260-266, 1995.

Suh, N., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., and Pezzuto, J.M. Discovery of natural products as chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res., 15: 233-240, 1995.

Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J.A., Tait, R.M., Besterman, J.M., and Harris, R.J.R. Novel strategies for plant-derived anticancer agents. Int. J. Pharmacog., 33 (Suppl.): 48-58, 1995.

Chaudhuri, S.K., Fullas, F., Brown, D.M., Wani, M.C., Wall, M.E., Cai, L., Mar, W., Lee, S.-K., Luo, Y., Zaw, K., Fong, H.H.S., Pezzuto, J.M. and Kinghorn, A.D. Pentacyclic triterpenoids from Maprounea africana as potential antagonists of tumor-promoting phorbol esters. J. Nat. Prod., 58: 1-9, 1995.

Falch, B.S., König, G.M., Wright, A.D., Sticher, O., Angerhofer, C.K., and Pezzuto, J.M. and Bachmann, H. Biological activities of cyanobacteria: evaluation of extracts and pure compounds. Planta Med., 61: 11-18, 1995.

You, M., Wickramaratne, M., Silva, G.L., Chai, H., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. (-)-Roemerine, an aporphine alkaloid from Annona Senegalensis that reverses the multiple drug resistance phenotype with cultured cells. J. Nat. Prod., 58: 598-604, 1995.

Pengsuparp, T., Cai, L., Constant, H., Fong, H.H.S., Lin, L.-Z., Kinghorn, A.D., Pezzuto, J.M., Cordell, G.A., Ingolfsdottir, K., Wagner, H., and Hughes, S.H. Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J. Nat. Prod., 58: 1024-1031, 1995.

Silva, G.L., Chai, H., Gupta, M.P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Beecher, C.W.W., and Kinghorn, A.D. Cytotoxic biflavonoids from Selaginella willdenowii. Phytochemistry, 40: 129-134, 1995.

Gil, R.R., Lin, L.-Z., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cardinolides from Nirerembergia aristata. J. Nat. Prod., 58: 848-856, 1995.

Pisha, E., Chai, H., Lee, I.-S., Chagweder, T.E., Farnsworth, N.R., Cordell, G.A., Beecher, C.W.W., Fong, H.H.S., Kinghorn, A.D., Brown, D.M., Wani, M.C., Wall, M.E., Hieken, T.J., Das Gupta, T.K., and Pezzuto, J.M. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature Medicine, 1: 1046-1051, 1995 (Cover article for issue Number 10, October 1995).

Kennelly, E.J., Cai, L., Long, L., Shamon, L., Zaw, K., Zhow, B.-N., Pezzuto, J.M., and Kinghorn, A.D. Novel highly sweet secodammarane glycosides from Pterocarya paliurus. J. Agric. Food Chem., 43: 2602-2607, 1995.

Fullas, F., Brown, D.M., Wani, M.C., Wall, M.E., Chagwedera, T.E., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera. J. Nat. Prod., 58: 1625-1628, 1995.

Swanson, S.M. and Pezzuto, J.M. Enhancement of benzo(a)pyrene metabolism mediated by retinol acetate in cultured human bronchial epithelial cells. Oncol. Rep., 2: 1011-1015, 1995.

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Lin, L.-Z., Hu, S.-F., Chai, H., Pengsuparp, T., Pezzuto, J.M., Cordell, G.A., Ruangrungsi, N. Lycorine alkaloids from Hymenocallis littoralis. Phytochemistry, 40: 1295-1298, 1995.

Gil, R.R., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cardenolides from Nierembergia aristata. J. Nat. Prod., 58: 848-856, 1995.

Leaman, D.J., Arnason, J.T., Yusuf, R., Sangat-Roemantyo, H., Soedjito, H., Angerhofer, C.K., and Pezzuto, J.M. Malaria remedies of the Kenyah of the Apau Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy. J. Ethnopharmacol., 49: 1-16, 1995.

Öksüz, S., Gürek, F., Gill, R.R., Pengsuparp, T., Pezzuto, J.M., and Cordell, G.A. Four diterpene esters from Euphorbia myrisinites. Phytochemistry, 38: 1457-1462, 1995.

Tan, G.T., Lee, S., Lee, I.-S., Chen, J., Leitner, P., Besterman, J.M., Kinghorn, A.D., and Pezzuto, J.M. Natural product inhibitors of human DNA ligase I. Biochem. J., 314: 993-1000, 1996.

Yoshida, T., Hashimoto, Takaoka, S., Kan, Y., Tori, Asakawa, Y., Pezzuto, J.M., Pengsuparp, T., and Cordell, G.A. Phenolic constituents of the liverwort: four novel cyclic bisbibenzyl dimers from Blasia pusilla L. Tetrahedron 52: 14487-14500, 1996.

Flavin, M.T., Rizzo, J.D., Khilevich, A., Kucherenko, A., Sheinkman, A.K., Vilaychack, V., Lin, L., Chen, W., Mata-Greenwood, E., Pengsuparp, T., Pezzuto, J.M., Hughes, S.H., Flavin, T.M., Cibulski, M., Boulanger, W.A., Shone, R.L., and Xu, Z.-Q. Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (")-calanolide A and its enantiomers. J. Med. Chem., 39: 1303-1313, 1996.

Lee, I.-S., Shamon, L.A., Chai, H.-B., Chagwedera, T.E., Besterman, J.M., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D. Cell-cycle specific cytotoxicity mediated by rearragned ent-kaurene diterpenoids isolated from Parinai curatellifolia. Chem.-Biol. Interactions, 99: 193-204, 1996.

Pezzuto, J.M. Bioassay-directed isolation of natural product drugs. ICAST 96 Proceedings. The 12th International Conference on Advanced Science and Technology, 12: 23-28, 1996.

Öksüz, S., Gürek, F., Lin, L.-Z., Gil, R.R., Pezzuto, J.M., and Cordell, G.A., Aleppicatines A and B from Euphorbia aleppica. Phytochemistry, 42: 473-478, 1996.

Luyengi, L., Suh, N., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. A Lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells. Phytochemistry, 43: 409-412, 1996.

Sun, H.-D., Qiu, S.-X., Lin, L.-Z., Wang, Z.-Y., Lin, Z.-W., Pengsuparp, T., Pezzuto, J.M., Fong, H.H.S., Cordell, G.A., and Farnsworth, N.R. Nigranoic Acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J. Nat. Prod., 59: 525-527, 1996.

Pengsuparp, T., Kingston, D.G.I., Neidigh, K.A., Cordell, G.A., and Pezzuto, J.M. Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol. Chem.-Biol. Interactions, 101: 103-114, 1996.

Sturm, S., Gil, R.R., Chai, H.-B., Nsassapa, O.D., Santisuk, T., Reutrakul, V., Howe, A., Moss, M., Besterman, J.M., Yang, S.-L., Farthing, J.E., Tait, R.M., Lewis, J.A., O'Neill, M.J.,

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Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Lupane derivatives from Lophopetalum wallichii with farnesyl protein transferase inhibitory activity. J. Nat. Prod., 59: 658-663, 1996.

Pengsuparp, T., Serit, M., Hughes, S.H., Soejarto, D.D., and Pezzuto, J.M. Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of Calophyllum teysmannii. J. Nat. Prod., 59: 839-842, 1996.

Poobrasert, O., Chai, H., Pezzuto, J.M., and Cordell, G.A. A cytotoxic degradation product of physostigmine. J. Nat. Prod., 59: 1087-1089, 1996.

Mbwambo, Z.H., Lee, S.K., Mshiu, E.N., Pezzuto, J.M., and Kinghorn, A.D. Constituents from the stem wood of Euphorbia quinquecostata with phorbol dibutyrate receptor-binding inhibitory activity. J. Nat. Prod., 57: 1051-1055, 1996.

Mehdi, H., Tan, G.T., Pezzuto, J.M., Fong, H.H.S., Farnsworth, N.R., El-Feraly, F.S., Al-Yahya, M.A., Mossa, J.S., Peeples, M.E., and Rozhon, E. Cell culture assay system for the evaluation of natural product-mediated anti-hepatitis B viral activity. Phytomedicine, 3: 369-377, 1996.

Wall, M.E., Wani, M.C., Brown, D.M., Fullas, F., Oswald, J.B., Josephson, F.F., Thornton, N.M., Pezzuto, J.M., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., and Kinghorn, A.D. Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal. Phytomedicine, 3: 281-285, 1996.

Jang, M.-S. and Pezzuto, J.M. Assessment of cyclooxygenase inhibitors using in vitro assay systems. Meth. Cell Sci., 19: 25-31, 1997.

Pisha, E. and Pezzuto, J.M. Cell-based assay for the determination of estrogenic and anti-estrogenic activity. Meth. Cell Sci., 19: 37-43, 1997.

Shamon, L.A. and Pezzuto, J.M. Assessment of antimutagenic activity with Salmonella typhimurium strain TM677. Meth. Cell Sci., 19: 57-62, 1997.

Jang, M., Cai, L., Udeani, G.O., Slowing, K., Thomas, C.F., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275: 218-220, 1997.

Gerhäuser, C., You, M., Liu, J., Moriarty, R.M., Hawthorne, M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Cancer chemopreventive potential of sulforamate, a novel analog of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Res., 57: 272-278, 1997.

Shamon, L., Pezzuto, J.M., Graves, J.M., Mehta, R.R., Wangcharoentrakul, S., Sangsuwan, R., Chaichana, S., Tuchinda, P., Cleason, P., and Reutrakul, V. Evaluation of the mutagenic and antitumor potential of triptolide, a highly cytotoxic diterpene isolated from Trypterygium wilfordii. Cancer Lett., 112: 113-117, 1997.

Grzybek, J., Wongpanich, V., Mata-Greenwood, E., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. Biological evaluation of selected plants from Poland. Int. J. Pharmacog., 35: 1-5, 1997.

Öksüz, S., Gürek, F., Yang, S.-W., Lin, L.-Z., Cordell, G.A., Pezzuto, J.M., Wagner, H., and Lotter, H. Paralinones A and B, diterpene esters from Euphorbia paralias. Tetrahedron, 53:

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3215-3222, 1997.

Arda, N., Goren, N., Kuru, A., Pengsuparp, T., Pezzuto, J.M., Qiu, S.-X., and Cordell, G.A. Saniculoside N from Sanicula europaea L. J. Nat. Prod., 60: 1170-1173, 1997.

Chung, M.-S., Kim, N.-C., Long, L., Shamon, L., Ahmad, W.-Y., Sagrero-Nieves, L., Kardono, L.B.S., Kennelly, E.J., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Dereplication of saccharide and polyol constituents of candidate sweet-tasting plants: isolation of the sesquiterpene glycoside mukurozioside IIb as a sweet principle of Sapindus rarak. Phytochem. Anal., 8: 49-54, 1997.

Lu, G.-H., Wang, F.-P., Pezzuto, J.M., Tam, T.C.M., Williams, I.D., and Che, C.-T. 10-Epi-Olguine from Rabdosia ternifolia. J. Nat. Prod., 60: 425-427, 1997.

MacKinnon, S., Durst, T., Arnason, J.T., Angerhofer, C., Pezzuto, J.M., Sanchez-Vindas, P.E., Poveda, L.J., and Gbeassor, M. Antimalarial activity of tropical meliaceae extracts and gedunin derivatives. J. Nat. Prod., 60: 336-341, 1997.

Horgen, F.D., Guinaudeau, H., Pezzuto, J.M., Soejarto, D.D., Farnsworth, N.R., Agcaoili, F., de los Reyes, G., and Edrada, R.A. Isolation and structure elucidation of ardisenone: A new cytotoxic alkenylphenol from Ardisia iwahigensis. J. Nat. Prod., 60: 533-535, 1997.

Shen, L., Pisha, E., Huang, Z., Pezzuto, J.M., Krol, E., Alam, Z., van Breemen, R.B., and Bolton, J.B. Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis, 18: 1093-1101, 1997.

Mossa, J.S., El-Feraly, F.S., Muhammad, I., Zaw, K., Mbwambo, Z.H., Pezzuto, J.M., and Fong, H.H.S. Sesquiterpene lactones and thymol esters from Vicoa pentanema. J. Nat. Prod., 60: 550-555, 1997.

Seo, E.-K., Silva, G.L., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic prenylated flavanones from Monotes engleri. Phytochemistry, 45: 509-515, 1997.

Udeani, G.O., Gerhäuser, C., Thomas, C.F., Moon, R.C., Kosmeder, J.W., Kinghorn, A.D., Moriarty, R.M., and Pezzuto, J.M. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res., 57: 3424-3428, 1997.

Gerhäuser, C., Kosmeder, J.W., Moriarty, R.M., Hamel, E., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res., 57: 3429-3435, 1997.

Constant, H.L., Graham, J.L., Pezzuto, J.M., Cordell, G.A., and Beecher, C.W.W. A general method for the dereplication of flavonoid glycosides utilising HPLC/MS analysis. Phytochem. Anal., 8: 176-180, 1997.

Hedayat, S., Yan, B., and Pezzuto, J.M. Modeling and identifying optimum designs for fitting dose-response based on raw optical density data. J. Amer. Statist. Assoc., 92: 1132-1140, 1997.

Bolton, J.L., Pisha, E., Shen, L., Krol, E.S., Iverson, S.L., Huang, Z., van Breemen, R.B., and Pezzuto, J.M. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human malignant melanoma cells. Chem.-Biol.

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Interact., 106: 133-148, 1997.

Kim, D.S.H.L., Chen, Z., van Tuyen Nguyen, Pezzuto, J.M., Qiu, S., and Lu, Z.-Z. A concise semi-synthetic approach to betulinic acid from betulin. Synth. Commun., 27: 1607-1612, 1997.

Chang, L.C., Gerhäuser, C., Song, L.L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of constituents of Tephrosia purpurea with potential to induce the phase II enzyme quinone reductase. J. Nat. Prod., 60: 869-873, 1997.

Chen, I.-S., Tsai, I.-W., Teng, C.-M., Chen, J.-J., Chang, Y.-L., Ko, F.N., Lu, M.C., and Pezzuto, J.M. Pyranoquinoline alkaloids From Zanthoxylum simulans. Phytochemistry, 46: 525-529, 1997.

Kennelly, E.J., Gerhäuser, C., Song, L.L., Graham, J.G., Beecher, C.W.W., Pezzuto, J.M., and Kinghorn, A.D. Induction of quinone reductase by withanolides isolated from Physalis philadelphica (Tomatillos). J. Agric. Food Chem., 45: 3771-3777, 1997.

Schmidt, M.L., Kuzmanoff, K.L., Ling-Indeck, L., and Pezzuto, J.M. Betulinic acid induces apoptosis in human neuroblastoma cell lines. Eur. J. Cancer, 33: 2007-2010, 1997.

Çaliş, İ., Yürüker, A., Taşdemir, Wright, A.D., Sticher, O., Lou, Y.-D. Luo, and Pezzuto, J.M. Cycloartane triterpene glycosides from the roots of Astragalus melanophruruis. Planta Med., 63: 183-186, 1997.

Cui, B., Chai, H., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic 1H-cyclopentatetrahydro(b)benzofuran lignans from Aglaia elliptica. Tetrahedron, 53: 17625-17632, 1997.

Lin, Y.-M., Anderson, H., Flavin, M.T., Pai, Y.-H.S., Mata-Greenwood, E., Pengsuparp, T., Pezzuto, J.M., Schinazi, R.F., Hughes, S.H., and Chen, F.C. In Vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. J. Nat. Prod., 60: 884-888, 1997.

Horgen, F.D., Madulid, D.A., Angerhofer, C.K., Pezzuto, J.M., Soejarto, D.D., and Farnsworth, N.R. Isolation of gallic acid esters as antiplasmodial constituents of Swintonia foxworthyi (Anacardiaceae). Phytomedicine, 4: 353-346, 1997.

Silva, G.L., Gil, R.R., Cui, B., Chai, H., Santisuk, T., Srisook, E., Reutrakul, V., Tuchinda, P., Sophasan, S., Sujarit, S., Upatham, S., Lynn, S.M. Farthing, J.E., Yang, S.-L., Lewis, J.A., O’Neill, M.J., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic ring-A seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis. Tetrahedron, 53: 529-538, 1997.

Long, L., Lee, S.K., Chai, H.-B., Rasoanaivo, P., Gao, Q., Navarro, H., Wall, M.E., Wani, M.C., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron, 53: 15663-15670, 1997.

Mebe, P., Cordell, G.A., and Pezzuto, J.M. Pentacyclic triterpenes and naphthoquinones from Euclea divinorum. Phytochemistry 47: 311-313, 1998.

Lee, S.K., Mbwambo, Z.H., Chung, H.-S., Luyengi, L., Gamez, E.J.C., Mehta, R.G., Kinghorn, A.D., and Pezzuto, J.M. Evaluation of the antioxidant potential of natural products. Comb. Chem. High Throughput Screen., 1: 35-46, 1998.

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David, J.M., Chavez, J.P., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Two new cytotoxic compounds from Tapirira guianensis. J. Nat. Prod., 61: 287-289, 1998.

Gamez, E.J.C., Luyengi, L., Lee, S.K., Zhu, L.-F., Zhou, B.-N., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antioxidant flavonoid glycosides from Daphniphyllum calycinum. J. Nat. Prod., 61: 706-708, 1998.

Pezzuto, J.M., Angerhofer, C.K., and Mehdi, H. Discovery and characterization of natural product drugs. ICAST 98 Proceedings. The 14th International Conference on Advanced Science and Technology, 14: 373-384, 1998.

Lee, S.K., Qing, W.G., Mar, W., Luyengi, L., Mehta, R.G., Kawanishi, K., Fong, H.H.S., Beecher, C.W.W., Kinghorn, A.D., and Pezzuto, J.M. Angoline and chelerythrine, benzophenanthridines that do not inhibit protein kinase C. J. Biol. Chem., 273: 19829-19833, 1998.

Dharmarathne, H.R.W., Wanigasekara, W.M.A.P., Mata-Greenwood, E., and Pezzuto, J.M. Inhibition of human immunodeficiency virus type I reverse transcriptase activity by cordatolides isolated from Calophyllum cordato-oblongum. Planta Med., 64: 460-461, 1998.

Subbaramaiah, K., Chung, W.J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J.M., and Dannenberg, A.J. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-21882, 1998.

Cui, B., Chai, B., Constant, H.L., Santisuk, T., Reutrakul, V., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Limonoids from Azadirachta excelsa. Phytochemistry, 47: 1283-1287, 1998.

Ito, A., Shamon, L.A., Yu, B., Mata-Greenwood, E., Lee, S.K., van Breemen, R.A., Mehta, R.G., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity. J. Agr. Food Chem., 46: 3509-3516, 1998.

Chang, L.C., Bhat, K.P.L., Pisha, E., Kennelly, E., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of steroid alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J. Nat. Prod., 61: 1257-1262, 1998.

El Sayed, K.A., Hamann, M.T., Waddling, C.A., Jensen, C., Lee, S.K., Dunstan, C.A., and Pezzuto, J.M. Structurally novel bioconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation. J. Org. Chem., 63: 7449-7455, 1998.

Lee, S.K., Cui, B., Mehta, R.R., Kinghorn, A.D., and Pezzuto, J.M. Cytostatic Mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica. Chem.-Biol. Interact., 115: 215-228, 1998.

Jang, M. and Pezzuto, J.M. Resveratrol blocks eicosanoid production and chemically-induced cellular transformation: implications for cancer chemoprevention. Pharm. Biol., 36: 28-34, 1998.

Cui, B., Chai, H., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic acylated oligorhamnosides from Mezzettia leptopoda. J. Nat. Prod., 61: 1535-1538, 1998.

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Poobrasert, O., Constant, H.L., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., Cordell, G.A., Santisuk, T., and Reutrakul, V. Xanthones from the twigs of Mammea siamensis. Phytochemistry, 47: 1661-1663, 1998.

Jang, J., and Pezzuto, J.M. Effects of resveratrol on 12-O-tetradecanoylphobol-13-acetate-induced oxidative events and gene expression in mouse skin. Cancer Lett., 134: 81-89, 1998.

Qui, S.-X., Sun, H.-D., Lobkovsky, E., Chai, H., Clardy, J., Farnsworth, N.R., Pezzuto, J.M., and Fong, H.H.S. Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus. Planta Med., 64: 728-731, 1998.

Kim, D.S., Pezzuto, J.M., and Pisha, E. Synthesis of betulinic acid derivatives with activity against human melanoma. Bioorg. Med. Chem. Lett., 8: 1707-0712, 1998.

Yoosook, C., Reutrakul, V., Santisuk, T., Chaichana, S., Pezzuto, J.M., Dong, Y., Clanton, D.J., Kiser, R., and Staley, P. A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory. SE Asian J. Trop. Med. Public Health, 29: 758-762, 1998.

Song, L.L., Kosmeder II, J.W., Lee, S.K., Gerhäuser, C., Lantvit, D., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res., 59, 578-585, 1999.

Angerhofer, C.K., Guinaudeau, H., Wongpanich, V., Pezzuto, J.M., and Cordell, G.A. Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. J. Nat. Prod., 62: 59-66, 1999.

Chung, H.S., Chang, L.C., Lee, S.K., Shamon, L.A., van Breemen, R.B., Mehta, R.G., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity. J. Agric. Fd. Chem., 47: 36-41, 1999.

Lin, L.-Z., Hu, S.-F., Chu, M., Chan, T.-M., Chai, H., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi. Phytochemistry, 50: 829-834, 1999.

Lee, S.K., Luyengi, L., Mar, W., Gerhäuser, C., Lee, K., Mehta, R.G., Kinghorn, A.D., and Pezzuto, J.M. Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity. Cancer Lett., 136: 59-65, 1999.

Chatterjee, P., Pezzuto, J.M., and Kouzi, S.A. Glucosidation of betulinic acid by Cunninghamella species. J. Nat. Prod. 62: 761-763, 1999.

Jang, M. and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol. Drugs Exptl. Clin. Res., XXV: 65-77, 1999.

Seo, E.-K., Chai, H., Constant, H.L., Santisuk, T., Reutrakul, V., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Resveratrol tetramers from Valica diospyroides. J. Org. Chem., 64: 6976-6983, 1999.

Alberts, D.S., Colvin, O.M., Conney, A.H., Ernster, V.L., Garber, J.E., Greenwald, P., Gudas, L.J., Hong, W.K., Kelloff, G.J., Kramer, R.A., Lerman, C.E., Mangelsdorf, D.J., Matter, A., Minna, J.D., Nelson, W.G., Pezzuto, J.M., Prendergast, F., Rusch, V.W., Sporn, M.B., Wattenberg, L.W., and Weinstein, B. Prevention of cancer in the next millennium. Report of the

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Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res., 59: 4743-4758, 1999.

Jeong, H.-J., Shin, Y.G., Kim, I.-H., and Pezzuto, J.M. Inhibition of aromatase activity by flavonoids. Arch. Pharmacal Res., 22: 309-312, 1999.

Shin, Y.G., Cho, K.H., Chung, S.M., Graham, J., Das Gupta, T.K., Pezzuto, J.M. Determination of betulinic acid in mouse blood, tumor and tissue homogenates by HPLC-electrospray/MS. J. Chromatogr. B, 732: 331-336, 1999.

Cui, B., Chai, B., Dong, Y., Horgen, F.D., Hansen, B., Madulid, D.A., Soejarto, D.D., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Quinoline alkaloids from Acronychia laurifolia. Phytochemistry 52: 95-98, 1999.

Ito, A., Lee, Y.-H., Chai, H.-B., Gupta, M.P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. 1',2',3',4'-Tetradehydrotubulosine, a aytotoxic alkaloid from Pogonopus speciosus. J. Nat. Prod., 62: 1346-1348, 1999.

Qui, S.-X., Lu, Z.-Z., Luyengi, L., Lee, S.K., Pezzuto, J.M., Farnsworth, N.R., Thompson, L.U., and Fong, H.H.S. Isolation and characterization of flaxseed (Linum usitatissimum) Constituents. Pharm. Biol., 37: 1-7, 1999.

Cui, B., Lee, Y.H., Chai, H., Tucker, J.C., Fairchild, C.R., Raventos-Suarez, C., Long, B., Lane, K.E., Menendez, A.T., Beecher, C.W.W., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic sesquiterpenoids from Ratibida columnifera. J. Nat. Prod., 62: 1545-1550,1999.

Lee, S.K. and Pezzuto, J.M. Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity. Arch. Pharm. Res., 22: 559-564, 1999.

Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res., 19: 35-44, 1999.

Topcu, G., Erenler, R., Cakmak, O., Johansson, C.B., Celik, C., Chai, H.B., and Pezzuto, J.M. Diterpenes from the berries of Juniperus excelsa. Phytochemistry, 50: 1195-1199, 1999.

Kinghorn, A.D., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Udeani, G.O., Wani, M.C., Wall, M.E., Navarro, H.A., Kramer, R.A., Menendez, A.T., Fairchild, C.R., Lane, K.E., Forenza, S., Vyas, D.M., Lam, K.S., and Shu, Y.-Z. Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl. Chem., 71: 1611-1618, 1999.

Hedayat, A.S., Yan, B., Searle, G.D., and Pezzuto, J.M. Pezzuto. Designs for fitting non-linear dose-response curve. Proc. Biopharm. Sec. Am. Stats. Assoc., 132-137, 1999.

Udeani, G.O., Zhao, G.-M., Shin, Y.G., Cooke, B.P., Graham, J. Beecher, C.W.W., Kinghorn, A.D., and Pezzuto, J.M. Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice. Biopharm. & Drug Disp., 20: 379-383, 1999.

Soejarto, D.D., Gyllenhaal, C., Regalado, J.C., Pezzuto, J.M., Fong, H.H.S., Tan, G.T., Xuan, L.T., Bich, T.Q., Southavong, B.H., and O'Neill, M.J. Studies on biodiversity of Vietnam and Laos: a UIC-based ICBG program. Pharm. Biol., 37 (Suppl.): 100-113, 1999.

Ulubelen, A., Topçu, G., Chai, H.-B., and Pezzuto, J.M. Cytotoxic activities of diterpenoids

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isolated from Salvia hypargeia. Pharm. Biol., 37: 148-151, 1999.

David, J.P., Santon, A.J., Guedes, M.L., David, J.M., Chai, H.-B., Pezzuto, J.M., Angerhofer, C.K., and Cordell, G.A. Sesquiterpene lactones from Ambrosia artemisiaefolia (Asteraceae). Pharm. Biol., 37: 165-168, 1999.

Yang, S.-W., Cordell, G.A., Chai, H.B., Jang, M.S., and Pezzuto, J.M. Cytotoxic activity of some indole derivatives and indole metabolites of Streptomyces staruosporeus. Pharm. Biol., 37: 67-70, 1999.

Shin, Y.G., Cordell, G.A., Dong, Y., Pezzuto, J.M., Venkata, A., Rao, N.A., Ramesh, M., Kumar, B.R., and Radhakishan, M. Rapid identification of cytotoxic alkenyl catechols in Semecarpus anacardium using bioassay-linked HPLC-electrospray/MS analysis. Pytochem. Anal., 10: 208-212, 1999.

Fong, H.H.S., Kosmeder, J.W., Farnsworth, N.R., Soejarto, D.D., Kinghorn, A.D., and Pezzuto, J.M. Edible plants as sources of cancer chemopreventive agents. Intl. Forum Trad. Med. Proc., October 16-17, 1999: 63-72.

Chang, L.C., Chávez, D., Song, L.L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea. Org. Lett., 2: 515-518, 2000.

Adeniyi, B.A., Fong, H.H., Pezzuto, J.M., Luyengi, L., and Odelola, H.A. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria. Phytother. Res., 14: 112-117, 2000.

Peraza-Sánchez, S.R., Chávez, D., Chai, H.-B., Shin, Y.G., García, R., Mejía, M., Fairchild, C.R., Lane, K.E., Menendez, A.T., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the roots of Ekmanianthe longiflora. J. Nat. Prod., 63: 492-495, 2000.

Seo, E.-K., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. 5-(4-Hydroxyphenethenyl)-4,7-dime-thoxycoumarin, a new constituent of Monotes engleri. Planta Med., 66: 182-184, 2000.

Tan, G.T., Angerhofer, C.K., and Pezzuto, J.M. Assays useful for the discovery and characterization of natural product drugs. Adv. Nat. Sci., 12: 39-56, 2000.

Chang, L.C., Bhat, K.P.L., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Novel bioactive steroid alkaloids from Pachysandra procumbens. Tetrahedron, 56: 3133-3138, 2000.

Nikolic, D., Goudarzi-Habibi, S., Corley, D.G., Gafner, S., Pezzuto, J.M., and van Breemen, R.B. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry. Anal. Chem., 72: 3853-3859, 2000.

Jeong, H.-J., Chang, L.C., Kim, H.-K., Kim, I.-K., Kinghorn, A.D., and Pezzuto, J.M. Aromatase inhibitors from Isodon excisus var. coreanus. Arch. Pharmacal Res., 23: 243-245, 2000.

Chang, L.C., Song, L.L., Park, E.J., Luyengi, L., Lee, K.J., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Bioactive constituents of Thuja occidentalis. J. Nat. Prod., 63: 1235-1238, 2000.

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Qiu, S.X., Li, X.C., Xiong, Y., Dong, Y., Chai, H., Farnsworth, N.R., Pezzuto, J.M., and Fong, H.H.S. Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense. Planta Med., 66: 587-590, 2000.

Chatterjee, P., Kouzi, S.A., Pezzuto, J.M., and Hamann, M.T. Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368. Appl. Environ. Microbiol., 66: 3850-3855, 2000.

Ingólfsdóttir, K., Lee, S.K., Bhat, K.P.L., Lee, K., Chai, H.-B., Kristinsson, H., Song, L.L., Gills, J., Gudmundsdóttir, J.T., Mata-Greenwood, E., Jang, M.S., and Pezzuto, J.M. Evaluation of selected lichens from Iceland for cancer chemopreventive and cytotoxic activity. Pharm. Biol., 38: 313-317, 2000.

Ito, A., Chai, H.-B., Shin, Y.-G., Garcia, R., Mejia, M., Gao, Q., Fairchild, C.R., Lane, K.E., Menendez, A.T., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the roots of Exostema acuminatum. Tetrahedron, 56: 6401-6405, 2000.

Chang, L.C., Chávez, D., Gills, J., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia. Tetrahedron Lett., 41: 7157-7162, 2000.

Cho, K.H., Pezzuto, J.M., Bolton, J.L., Steele, V.E., Kelloff, G.J., Lee, S.K., and Constantinou, A. Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. Eur. J. Cancer, 36: 2146-2156, 2000.

Chang, L.C., Gills, J.J., Bhat, K.P.L., Luyengi, L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. Bioorg. Med. Chem. Lett., 10: 2431-2434, 2000.

Kouzi, S.A., Chatterjee, P., Pezzuto, J.M., and Hamann, M.T. Microbial transformations of the antimelanoma agent betulinic acid. J. Nat. Prod., 63: 1653-1657, 2000.

Cuendet, M. and Pezzuto, J.M. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metab. Drug Interac., Special Issue: Effects of Phytochemicals on Drug Metabolising Enzymes and Health, 17: 109-157, 2000.

Westenburg, H.E., Lee, K.-J., Lee, S.-K., Fong, H.H.S., van Breemen, R., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J. Nat. Prod., 63: 1696-1998, 2000.

Kandil, F, L. Song, J.M. Pezzuto, K. Marley, D.S. Seigler, and M.A.L. Smith. Isolation of oligomeric proanthocyanidins from flavonoid-producing cell cultures. In Vitro Cell. Dev. Biol.-Plant, 36: 492-500, 2000.

Calderon, A.I., Angerhofer, C.K., Pezzuto, J.M., Farnsworth, N.R., Foster, R., Condit, R., Gupta, M.P., and Soejarto, D.D. Forest plot as a tool to demonstrate the pharmaceutical potential of plants in a tropical forest of Panama. Econ. Bot., 54: 278-294, 2000.

Waffo-Teguo, P., Lee, D., Cuendet, M., Mérillon, J.-M., Pezzuto, J.M., and Kinghorn, A.D. Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. J. Nat. Prod., 64: 136-138, 2001.

Salti, G.I., Kichina, J.V., Das Gupta, T.K., Uddin, S., Bratescu, L., Pezzuto, J.M., Mehta, R.G., and Constantinou, A.I. Betulinic acid reduces ultraviolet-C-induced DNA breakage in

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congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent. Melanoma Res.,11: 99-104, 2001.

Udeani, G.O., Zhao, G.-M., Shin, Y.G., Kosmeder II, J.W., Beecher, C.W.W., Kinghorn, A.D., Moriarty, R.M., Moon, R.C., and Pezzuto, J.M. Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats. Cancer Chemother. Pharmacol., 47: 263-268, 2001.

Correia, S.J., David, J.M., David, J.P., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Alkyl phenols and derivatives from Tapirira obtusa. Phytochemistry, 56: 781-784, 2001.

Qiu, S.-X., Nguyen, V.H., Le, T.X., Gu, J.Q., Lobkovsky, E., Tran, C.K., Soejarto, D.D., Clardy, J., Pezzuto, J.M., Dong, Y., Mai, V.T., Le, M.H., and Fong, H.H.S. A pregnane steroid from Aglaia lawii and structure configuration of cabraleadiol monoacetate by x-ray crystallography. Phytochemistry, 56: 775-780, 2001.

Horgen, F.D., Edrada, R.A., de los Reyes, G., Agcaoili, F., Madulid, D.A., Wongpanich, V., Angerhofer, C.K., Pezzuto, J.M., Soejarto, D.D., and Farnsworth, N.R. Biological screening of rain forest plot trees from Palawan Island (Philippines). Phytomedicine, 8:71-81, 2001.

Mi, Q., Cui, B., Silva, G.L., Lantvit, D., Lim, E., Chai, H., You, M., Hollingshead, M.G., Mayo, J.G., Kinghorn, A.D., and Pezzuto, J.M. Pervilleine A., a novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer Res., 61: 4030-4037, 2001.

Park, E.J., Lee, D., Shin, Y.G., Lantvit, D.D., van Breemen, R.B., Kinghorn, A.D., and Pezzuto, J.M. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. J. Chromatog. B Biomed. Sci. Appl., 754: 327-332, 2001.

Liu, J., Burdette, J.E., Xu, H., Gu, C., van Breemen, R.B., Bhat, K.P., Booth, N.,

Constantinou, A.I., Pezzuto, J.M., Fong, H.H., Farnsworth, N.R., and Bolton, J.L. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J. Agric. Food Chem., 49:2472-2479, 2001.

Yu, R., Hebbar, V., Kim, D.W., Mandlekar, S., Pezzuto, J.M., and Kong, A.-N.T. Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol. Pharmacol., 60: 217-224, 2001.

Lee, D., Park, E.J., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata. Bioorg. Med. Chem. Lett., 11: 1565-1568, 2001.

Zhang, H.J., Tamez, P.A., Hoang, V.D., Tan, G.T., Hung, N.V., Xuan, L.T., Huong, L.M., Cuong, N.M., Thao, D.T., Soejarto, D.D., Fong, H.H., and Pezzuto, J.M. Antimalarial compounds from Rhaphidophora decursiva. J. Nat. Prod., 64: 772-777, 2001.

Ito, A., Cui, B., Chavez, D., Chai, H.B., Shin, Y.G., Kawanishi, K., Kardono, L.B., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. J. Nat. Prod., 64: 246-248, 2001.

Chávez, D., Chai, H.-B., Chagwedera, T.E., Gao, Q., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel stilbenes isolated from the root bark of Ekebergia benguelensis. Tetrahedron Lett., 42: 3685-3688, 2001.

Lee, D., Cuendet, M., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H., Pezzuto, J.M.,

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and Kinghorn, A.D. A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. Org Lett., 3: 2169-2171, 2001.

Mehta, R.G., Bhat, K.P., Hawthorne, M.E., Kopelovich, L., Mehta, R.R., Christov, K., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. J. Natl. Cancer Inst., 93:1103-1106, 2001.

Mata-Greenwood, E., Ito, A., Westenburg, H., Cui, B., Mehta, R.G., Kinghorn, A.D., and Pezzuto, J.M. Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells. Anticancer Res. 21: 1763-1770, 2001.

Bhat, K.P. and Pezzuto, J.M. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res., 61: 6137-6144, 2001.

Tuchinda, P., Pohmakotr, M., Reutrakul, V., Thanyachareon, W., Sophasan, S., Yoosook, C., Santisuk, T., and Pezzuto, J.M. 2-Substituted furans from Polyalthia suberosa. Planta Med., 67: 572-575, 2001.

Gu, J., Park, E.J., Luyengi, L., Hawthorne, M.E., Mehta, R.G., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Eugenia sandwicensis with potential cancer chemopreventive activity. Phytochemistry, 58: 121-127, 2001.

Lee, D., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, and Kinghorn, A.D. Novel 29-nor-3,4-seco-cycloartane triterpene methyl esters from the aerial parts of Antirhea acutata. Tetrahedron, 57: 7107-7112, 2001.

Bhat, K.P.L., Lantvit, D., Christov, K., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res., 61:7456-7463, 2001.

Lee, D., Bhat, K.P.L., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Aromatase inhibitors from Broussonetia papyrifera. J. Nat. Prod., 64: 1286-1293, 2001.

Bhat, K.P.L., Kosmeder II, J.W., and Pezzuto, J.M. Forum Review Article: Biological effects of resveratrol. Antiox. Redox Signal., 3: 1041-1064, 2001.

Zhang, H.-J., Tan, G.T., Hoang, V.D., Hung, N.V., Cuong, N.M., Soejarto, D.D., Fong, H.H.S., and Pezzuto, J.M. Natural anti-HIV agents part II. Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata. Tetrahedron Lett., 42: 8587-8591, 2001.

Mata-Greenwood, E., Daeuble, J.F., Grieco, P.A., McChesney, J.D., Mehta, R.G., Kinghorn, A.D., and Pezzuto, J.M. Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture. J. Nat. Prod., 64: 1509-1513, 2001.

Bhat, K.P.L. and Pezzuto, J.M. Natural modulators of estrogen biosyntheis and function as chemopreventive agents. Arch. Pharm. Res., 24: 473-484, 2001.

Silva, G.L., Cui, B., Chávez, You, M., Chai, H.-B., Rasoanaivo, P., Lynn, S.M., O’Neill, M.J., Lewis, J.A., Beterman, J.M., Monks, A., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Modulation of the multi-drug resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei. J. Nat. Prod., 64: 1514-1520, 2001.

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Verotta, L., Guerrini, M., El-Sebakhy, N.A., Asaad, A.M., Toaima, S.M., Abou-Sheer, M.E., Luo, Y-D., and Pezzuto, J.M. Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia, 72: 894-905, 2001.

Seo, E.-K., Kim, N.-C., Mi., Q., Chai, H., Wall, M.E., Wani, M.C., Navarro, H.A., Burgess, J.P., Graham, J.G., Cabiesis, F., Tan, G.T., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum. J. Nat. Prod., 64: 1483-1485, 2001.

Waffo-Teguo, P., Hawthorne, M.E., Cuendet, M., Mérillon, J.-M., Kinghorn, A.D., Pezzuto, J.M., and Mehta, R.G. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr. Cancer, 40: 173-179, 2001.

Topçu, G., Ayral, M.N., Aydin, A., Gören, A.C., Chai, H.B., and Pezzuto J.M. Triterpenoids of the roots of Lavandula stoechas ssp. stoechas. Pharmazie., 56:892-895, 2001.

Constantinou, A.I., Lantvit, D., Hawthorne, M., Xu, X., van Breemen, R.B., and Pezzuto, J.M. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr. Cancer., 41: 75-81, 2001.

Calderón, A.I., Espósito-Avella, M., Buitrago de Tello, R.E., Pezzuto, J.M., Sánchez, C., and Gupta, M.P. Anti-inflammatory and analgesic activities of Vochysia ferruginea. Pharm. Biol., 39: 35-39, 2001.

Burdette, J.E., Liu, J., Lantvit, D., Lim, E., Booth, N., Bhat, K.P.L., Hedayat, S., van Breemen, R.B., Constantinou, A.I., Pezzuto, J.M., Farnsworth, N.R., and Bolton, J.L. Trifolium pratense (Red Clover) exhibits in vivo estrogenic effects in ovariectomized sprague-dawley rats. J. Nutrition, 132: 27-30, 2002.

Hoang, V.D., Tan, G.T., Zhang, H.-J., Tamez, P.A., Hung, N.V., Cuong, N.M., Soejarto, D.D., Fong, H.H.S., and Pezzuto, J.M. Natural anti-HIV agents. Part I. (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata. Phytochemistry, 59: 325-329, 2002.

Dharmaratne, H.R.W., Tan, G.T., Marasinghe, G.P.K., and Pezzuto, J.M. Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones. Planta Med., 68: 86-87, 2002.

Kandil, F.E., Smith, M.A., Rogers, R.B., Pepin, M.F., Song, L.L., Pezzuto, J.M., and Seigler, D.S. Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. J. Agric. Food Chem., 50: 1063-1069, 2002.

Perzaz-Sánchez, S.R., Chai, H.-B., Shin, Y.G., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the leaves and twigs of Ficus hispida. Planta Med., 68: 186-188, 2002.

Zhang, H., Fan, Z., Tan, G.T., Chai, H.B., Pezzuto, J.M., Sun, H., and Fong, H.H. Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodonpseudo-irrorata. J. Nat. Prod., 65: 215-217, 2002.

Su, B.N., Cuendet, M., Hawthorne, M.E., Kardono, L.B., Riswan, S., Fong, H.H., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the bark and twigs of Artocarpus dadah with Cyclooxygenase inhibitory activity. J. Nat. Prod., 65: 163-169, 2002.

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Minguzzi, S., Barata, L.E., Shin, Y.G., Jonas, P.F., Chai, H.B., Park, E.J., Pezzuto, J.M., and Cordell, G.A. Cytotoxic withanolides from Acnistus arborescens. Phytochemistry, 59: 635-641, 2002.

Zhang, H., Lu, Z., Tan, G.T., Qiu, S., Farnsworth, N.R., Pezzuto, J.M., and Fong, H.H.S. Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng. Tetrahedron Lett., 43: 973-977, 2002.

Lee, S.K., Heo, Y.H., Steele, V.E., and Pezzuto, J.M. Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Anticancer Res., 22: 97-102, 2002.

Gu, J.Q., Gills, J.J., Park, E.J., Mata-Greenwood, E., Hawthorne, M.E., Axelrod, F., Chavez, P.I., Fong, H.H., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J. Nat. Prod., 65: 532-536, 2002.

Chavez, D., Cui, B., Chai, H.B., Garcia, R., Mejia, M., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Reversal of multidrug resistance by tropane alkaloids from the stems of Erythroxylum rotundifolium. J. Nat. Prod., 65: 606-610, 2002.

Constantinou, A.I., Lucas, L.M., Lantvit, D., Hawthorne, M., Xu, X., Nho, C.W., Jeffery, E.H., Christov, K., van Breemen, R.B., and Pezzuto, J.M. Soy protein isolate prevents chemically-induced rat mammary tumors. Pharm. Biol., 40: 24-34, 2002.

Soejarto, D.D., Pezzuto, J.M., Fong, H.H.S., Tan, G.T., Zhang, H.J., Tamez, P., Aydogmus, Z., Chien, N.Q., Franzblau, S.G., Gyllenhaal, C., Regalado, J.C., Hung, N.V., Hoang, V.D., Hiep, N.T., Xuan, L.T., Hai, N.V., Cuong, N.M., Bich, T.Q., Loc, P.K., Vu, B.M., Southavong, B.H., Sydara, K., Bouamanivong, S., O’Neill, M.J., Lewis, J., and Dietzman, G. An international collaborative program to discover new drugs from tropical biodiversity of Vietnam and Laos. Nat. Prod. Sci., 8: 1-15, 2002.

Su, B.-N., Misico, R., Park, E.J., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica. Tetrahedron, 58: 3453-3466, 2002.

Misico, R.I., Song, L.L., Veleiro, A.S., Cirigliano, A.M., Tettamanzi, M.C., Burton, G., Bonetto, G.M., Nicotra, V.E., Silva, G.L., Gil, R.R., Oberti, J.C., Kinghorn, A.D., and Pezzuto, J.M. Induction of Quinone Reductase by Withanolides. J. Nat. Prod., 65: 677-680, 2002.

Hedayat, A.S., Yan, B., and Pezzuto, J.M. Optimum designs for estimating EDp based on raw optical density data. J. Stats. Plan. Inference, 104: 161-174, 2002.

Rimando, A.M., Cuendet, M., Desmarchelier, C., Mehta, R.G., Pezzuto, J.M., and Duke, S.O. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J. Agric. Food Chem., 50: 3453-3457, 2002.

Su, B.-N., Chang, L.C., Park, E.J., Cuendet, M., Santarsiero, B.D., Mesecar, A.D., Mehta, R.G., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Bioactive constituents of the seeds of Brucea javanica. Planta Med., 68: 730-733, 2002.

Cuendet, M. and Pezzuto J.M. Nonsteroidal anti-inflammatory drugs in cancer treatment. Expert Opin. Ther. Patents, 12: 827-835, 2002.

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Bhat, K.P. and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci., 957: 210-229, 2002.

Mi, Q., Lantvit, D., Reyes-Lim, E., Chai, H., Zhao, W., Lee, I.S., Peraza-Sanchez, S., Ngassapa, O., Kardono, L.B., Riswan, S., Hollingshead, M.G., Mayo, J.G., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., Pezzuto, J.M. Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests(1). J. Nat. Prod., 65: 842-850, 2002.

Blatt, C.T., Chavez, D., Chai, H., Graham, J.G., Cabieses, F., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. Phytother. Res., 16: 320-325, 2002.

Mi, Q., Cui, B., Silva, G.L., Lantvit, D., Lim, E., Chai, H., Hollingshead, M.G., Mayo, J.G., Kinghorn, A.D., and Pezzuto JM. Pervilleines B and C, new tropane alkaloid aromatic esters that reverse the multidrug-resistance in the hollow fiber assay. Cancer Lett., 184: 13-20, 2002.

Zhang, H., Qiu, S., Tamez, P., Tan, G.T., Aydogmus, Z., Hung, N.V., Cuong, N.M., Angerhofer, C., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Antimalarial agents from plants II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva. Pharm. Biol., 40: 221-224, 2002.

Gu, J.Q., Park, E.J., Totura, S., Riswan, S., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells. J. Nat. Prod., 65: 1065-1068, 2002.

Mi, Q., Cui, B., Chávez, D., Chai, H., Zhu, H., Cordell, G.A., Hedayat, S., Kinghorn, A.D., and Pezzuto, J.M. Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype. Anticancer Res., 22: 1385-1397, 2002.

Mehta, R.G. and Pezzuto, J.M. Discovery of cancer preventive agents from natural products: from plants to prevention. Curr. Oncol. Rep., 4: 478-486, 2002.

Su, B.-N., Park, E.J., Mbwambo, Z.H., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. J. Nat. Prod., 65: 1278-1282, 2002.

Christov, K.T., Moon, R.C., Lantvit, D., Boone, C.W., Steele, V.E., Lubet, R.A., Kelloff, G.J., and Pezzuto, J.M. 9-cis-Retinoic acid but not 4-(hydroxyphenyl)ratinamide inhibits prostate intraepithelial neoplasia in Noble rats. Cancer Res., 62: 5178-5182, 2002.

Jang, D.S., Park, E.J., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Santarsiero, B.D., Mesecar, A.D, Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Musa x paradisiaca Cultivar with the Potential To Induce the Phase II Enzyme, Quinone Reductase. J. Agric. Food Chem., 50: 6330-6334, 2002.

Mata-Greenwood, E., Cuendet, M., Sher, D., Gustin, D., Stock, W., and Pezzuto, J.M. Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc. Leukemia, 16: 2275-2284, 2002.

Burdette, J.E., Chen, S., Lu, Z.-Z., Xu, H., White, B., Fabricant, D.S., Liu, J., Fong, H.H.S., Farnsworth, N.R., Constantinou, A.I., van Breemen, R.B., Pezzuto, J.M., and Bolton, J.L. Black Cohosh (Cimicifuga racemosa L.) Protects against menadione-Induced DNA damage through

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scavenging of reactive oxygen species: Bioassay-directed Iiolation and characterization of Active Principles. J. Agricul. Food Chem., 50: 7022-7028, 2002.

Goren, A., Topcu, G., Bilsel, G., Bilsel, M., Aydogmus, Z., and Pezzuto, J.M. The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas. Z. Naturforsch, 57: 797-800, 2002.

Verotta, L., Guerrini, M., El-Sebakhy, N.A., Assad, A.M., Toaima, S.M., Radwan, M.M., Luo, Y.D., and Pezzuto, J.M. Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation. Planta Med., 68: 986-994, 2002.

Jang, D.S., Cuendet, M., Hawthorne, M.E., Kardono, L.B., Kawanishi, K., Fong, H.H., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Phytochemistry, 61: 867-872, 2002.

Murillo, G., Salti, G.I., Kosmeder, J.W. 2nd, Pezzuto, J.M., and Mehta, R.G. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur. J. Cancer, 38: 2446-2454, 2002.

Kosmeder, J.W. 2nd and Pezzuto, J.M. Novel plant-derived anticarcinogens. IARC Sci. Publ., 156: 343-347, 2002.

Zhang, H.J., Tamez, P.A., Aydogmus, Z., Tan, G.T., Saikawa, Y., Hashimoto, K., Nakata, M., Hung, N.V., Xuan le, T., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H. Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. Planta Med., 68: 1088-1091, 2002.

Su, B.N., Cuendet, M., Farnsworth, N.R., Fong, H.H., Pezzuto, J.M., and Kinghorn, A,D. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Planta Med., 68: 1125-1128, 2002.

Gu, J.-Q., Park, E.J., Vigo, J.S., Graham, J.G., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme, quinone reductase. J. Nat. Prod., 65: 1616-1620, 2002.

Calderon, A.I., Terreaux, C., Schenk, K., Burdette, J.E., Pezzuto, J.M., Gupta, M.P., and Hostettmann, K. Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J. Nat. Prod., 65: 1749-1753, 2002.

Park, E.J. and Pezzuto, J.M. Botanicals in cancer chemoprevention. Cancer Metast. Rev., 21: 231-255, 2002.

Xu, H., Fabricant, D.S., Piersen, C.E., Bolton, J.L., Pezzuto, J.M., Fong, H., Totura, S., Farnsworth, N.R., and Constantinou, A.I. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health. Phytomedicine, 9: 757-762, 2002.

Yu, C., Shin, Y.G., Chow, A., Li, Y., Kosmeder, J.W., Lee, Y.S., Hirschelman, W.H., Pezzuto, J.M., Mehta, R.G., and van Breemen, R.B. Human, rat, and mouse metabolism of resveratrol. Pharm. Res., 19: 1907-1914, 2002.

Ito, A., Chai, H.B., Lee, D., Kardono, L.B., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry, 61: 171-174, 2002.

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Kinghorn, A.D., Su, B.-N., Lee, D., Gu, J.-Q., and Pezzuto, J.M. Cancer chemopreventive agents discovered by activity-guided fractionation: An update. Curr. Org. Chem., 7: 213-226, 2003.

Hwang, B.Y., Chai, H.B., Kardono, L.B., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M. and Kinghorn, A.D. Cytotoxic triterpenes from the twigs of Celtis philippinensis. Phytochemistry, 62: 197-201, 2003.

Yu, C., Shin, Y.G., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun. Mass Spectrom., 17: 307-313, 2003.

Murillo, G., Kosmeder, J.W., Pezzuto, J.M., and Mehta, R.G. Deguelin suppresses the formation of aberrant crypt foci and loss of hexosaminidase activity in the colon of CF-1 mice. Intl. J. Cancer, 104: 7-11, 2003.

Duncan, C.J., Cuendet, M., Fronczek, F.R., Pezzuto, J.M., Mehta, R.G., Hamann, M.T., and Ross, S.A. Chemical and biological investigation of the fungus Pulveroboletus ravenelii. J. Nat. Prod., 66: 103-107, 2003.

Zhang, H.-J., Tan, G.T., Hoang, V.D., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Natural anit-HIV agents. Part 3: Litseaverticillols A-H, novel sesquiterpenes from Litsea verticillata. Tetrahedron, 59: 141-148, 2003.

Chun, K.H., Kosmeder, J.W. 2nd, Sun, S., Pezzuto, J.M., Lotan, R., Hong, W.K., and Lee, H.Y. Effects of deguelin on the phosphatidylinositol 3-kinase/akt pathway and apoptosis in premalignant human bronchial epithelial cells. J. Natl. Cancer Inst., 95: 291-302, 2003.

Su, B.N., Park, E.J., Nikolic, D., Santarsiero, B.D., Mesecar, A.D., Vigo, J.S., Graham, J.G., Cabieses, F., van Breemen, R.B., Fong, H.H., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D. Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity. J. Org. Chem., 68: 2350-2361, 2003.

Zhang, H.-J., Tan, G.T., Hoang, V.D., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. J. Nat. Prod., 66: 263-268, 2003.

Seo, E.-K., Lee, D., Shin, Y.G., Chai, H.-B., Navarro, H.A., Kardono, L.B., Rahman, I., Cordell, G.A., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., Wani, M.C., and Wall, M.E. Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Arch. Pharm. Res., 26: 124-127, 2003.

Su, B.-N., Cuendet, M., Nikolic, D., Kristinsson, H., Ingólfsdóttir, van Breemen, R.B., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. NMR study of fumarprotocetraric acid, a complex lichen depsidone derivative from Cladonia furcata. Magn. Resonance Chem., 41: 391-394, 2003.

Gafner, S., Bergeron, C., Batcha, L.L., Reich, J., Arnason, J.T., Burdette, J.E., Pezzuto, J.M., and Angerhofer, C.K. Inhibition of [(3)H]-LSD binding to 5-HT(7) receptors by flavonoids from Scutellaria lateriflora. J. Nat. Prod., 66: 535-537, 2003.

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Gu, J.-Q., Li, W., Kang, Y.-H., Su, B.-N., Fong, H.H.S., van Breemen, R.B., Pezzuto, J.M., and Kinghorn, A.D. Minor withanolides from Physalis philadelphica: Structures, quinone reductase induction activities, and LC-MS-MS investigation as artifacts. Chem. Pharm. Bull. (Tokyo), 51: 530-539, 2003.

Su, B.-N., Park, E.J., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay. Phytochemistry, 63: 335-341, 2003.

Fang, L., Chai, H.-B., Castillo, J.J., Soejarto, D.D., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of Brachistus stramoniifolius. Phytochem. Res., 17: 520-523, 2003.

Jang, D.S., Park, E.J., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Santarsiero, B.D., Mesecar, A.D., Fong H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (Tonka Bean). J. Nat. Prod., 66: 583-587, 2003.

Zhang, H.-J., Tan, G.T., Santarsiero, B.D., Mesecar, A.D., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. New sesquiterpenes from Litsea verticillata. J. Nat. Prod., 66: 609-615, 2003.

Topcu, G., Altiner, E.N., Gozcu, S., Halfon, B., Aydogmus, Z., Pezzuto, J.M., Zhou, B.N., and Kingston, D.G. Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity. Planta Med., 69: 464-467, 2003.

Omar, S., Zhang, J., MacKinnon, S., Leaman, D., Durst, T., Philogene, B.J.R., Arnason, J.T., Sanchez-Vindas, P.E., Poveda, L., Tamez, P.A., and Pezzuto, J.M. Traditionally-used antimalarials from the Meliaceae. Curr. Topics in Med. Chem., 3: 21-27, 2003.

Diaz, F., Chavez, D., Lee, D., Mi, Q., Chai, H.B., Tan, G.T., Kardono, L.B., Riswan, S., Fairchild, C.R., Wild, R., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J. Nat. Prod. 66: 865-867, 2003.

Tan, Y., Yu, R., and Pezzuto, J.M. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin. Cancer Res., 9: 2866-2875, 2003.

Su, B.N., Park, E.J., Nikolic, D., Vigo, J.S., Graham, J.G., Cabieses, F., van Breemen, R.B., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J. Nat. Prod., 66: 1089-1093, 2003.

Su, B.N., Kang, Y.H., Pinos, R.E., Santarsiero, B.D., Mesecar, A.D., Soejarto, D.D., Fong, H.H., Pezzuto, J.M., and Kinghorn A.D. Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis. Phytochemistry, 64: 293-302, 2003.

Burdette, J.E., Liu, J., Chen, S.N., Fabricant, D.S., Piersen, C.E., Barker, E.L., Pezzuto, J.M., Mesecar, A., van Breemen, R.B., Farnsworth, N.R., and Bolton, J.L. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J. Agric. Food Chem., 51: 5661-5670, 2003.

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Jang, D.S., Park, E.J., Kang, Y.H., Su, B.N., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Compounds obtained from Sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model. Arch. Pharm. Res., 26: 585-590, 2003.

Carcache-Blanco, E.J., Kang, Y.H., Park, E.J., Su, B.N., Kardono, L.B., Riswan, S., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. J. Nat. Prod., 66: 1197-1202, 2003.

Jang, D.S., Park, E.J., Kang, Y.H., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Potential cancer chemopreventive flavonoids from the stems of Tephrosia toxicaria. J. Nat. Prod., 66: 1166-1170, 2003.

Burdette, J.E., Liu, J., Chen, S., Fabricant, D.S., Piersen, C.E., Barker, E.L., Pezzuto, J.M., Mesecar, A., van Breemen, R.B., Farnsworth, N.R., and Bolton, J.L. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J. Agric. Food Chem., 51: 5661-5670, 2003.

Lee, K.H., Chai, H.B., Tamez, P.A., Pezzuto, J.M., Cordell, G.A., Win, K.K., and Tin-Wa M. Biologically active alkylated coumarins from Kayea assamica. Phytochemistry, 64: 535-541, 2003.

Topcu, G., Aydogmus, Z., Imre, S., Goren, A.C., Pezzuto, J.M., Clement, J.A., and Kingston, D.G. Brominated sesquiterpenes from the red alga Laurencia obtusa. J. Nat. Prod., 66: 1505-1508, 2003.

Mi, Q., Cui, B., Lantvit, D., Reyes-Lim, E., Chai, H., Pezzuto, J.M., Kinghorn, A.D., and Swanson, S.M. Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance. Anticancer Res., 23: 3607-3615, 2003.

Li, Y., Shin, Y.G., Yu, C., Kosmeder, J.W., Hirschelman, W.H., Pezzuto, J.M., and van Breemen, R.B. Increasing the throughput and productivity of caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb. Chem. High Throughput Screen., 6: 757-767, 2003.

Kinghorn, A.D., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Swanson, S.M., Pezzuto, J.M., Wani, M.C., Wall, M.E., Oberlies, N.H., Kroll, D.J., Kramer, R.A., Rose, W.C., Vite, G.D., Fairchild, C.R., Peterson, R.W., and Wild, R. Novel strategies for the discovery of plant-derived anticancer agents. Pharm. Biol., 41 (Suppl.): 53-67, 2003.

Villinski, J.R., Dumas, E.R., Chai, H.-B., Pezzuto, J.M., Angerhofer, C.K., and Gafner, S. Antimicrobial activity and alkaloid content of Berberis thunbergii, Berberis vulgaris and Hydrastis canadensis. Pharm. Biol., 41: 551-557, 2003.

Carcache-Blanco, E.J., Kang, Y.H., Park, E.J., Su, B.N., Kardono, L.B., Riswan, S., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. J. Nat. Prod., 67: 126, 2004.

Jang, D.S., Cuendet, M., Pawlus, A.D., Kardono, L.B., Kawanishi, K., Farnsworth, N.R., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. Phytochemistry. 65: 345-350, 2004.

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Liu, J., Burdette, J.E., Sun, Y., Deng, S., Schlecht, S.M., Zheng, W., Nikolic, D., Mahady, G., van Breemen, R.B., Fong, H.H., Pezzuto, J.M., Bolton, J.L., and Farnsworth, N.R. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. 11: 18-23, 2004.

Cuendet, M., Christov, K., Lantvit, D.D., Deng, Y., Hedayat, S., Helson, L., McChesney, J.D., and Pezzuto, J.M. Multiple myeloma regression mediated by bruceantin. Clin. Cancer Res., 10: 1170-1179, 2004.

Lee, H.Y., Suh, Y.A., Kosmeder, J.W., Pezzuto, J.M., Hong, W.K., and Kurie, J.M. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin. Cancer Res., 10: 1074-1079, 2004.

Soejarto, D.D., Gyllenhaal, C., Fong, H.H., Xuan, L.T., Hiep, N.T., Hung, N.V., Bich, T.Q., Southavong, B., Sydara, K., and Pezzuto, J.M. The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: A model of benefit-sharing arrangement in natural products drug discovery and development. J. Nat. Prod., 67: 294-299, 2004.

Cuendet, M. and Pezzuto, J.M. Antitumor activity of bruceantin: An old drug with new promise. J. Nat. Prod., 67: 269-272, 2004.

Ito, A., Chai, H.B., Kardono, L.B., Setowati, F.M., Afriastini, J.J., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Saponins from the bark of Nephelium maingayi. J. Nat. Prod., 67: 201-205, 2004.

Zhang, H.J., Sydara, K., Tan, G.T., Ma, C., Southavong, B., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H. Bioactive constituents from Asparagus cochinchinensis. J. Nat. Prod., 67: 194-200, 2004.

Su, B.-N., Gu, J.-Q., Kang, Y.-H., Park, E.J., Pezzuto, J.M., and Kinghorn, A.D. Induction of the phase II enzyme, quinone reductase, by withanolides and norwithanolides from Solanaceous species. Mini-Rev. Org. Chem., 1: 115-123, 2004.

Cuendet, M., Gills, J.J., and Pezzuto, J.M. Brusatol-induced HL-60 cell differentiation involves NF-B activation. Cancer Lett., 206: 43-50, 2004.

Jang, D.S., Park, E.J., Kang, Y.H., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase. Arch. Pharm. Res., 27: 169-172, 2004.

Diaz, F., Chai, H.B., Mi, Q., Su, B.N,, Vigo, J.S., Graham, J.G., Cabieses, F., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru. J. Nat. Prod., 67: 352-356, 2004.

Rivero-Cruz, J.F., Chai, H.B., Kardono, L.B., Setyowati, F.M., Afriatini, J.J., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Cytotoxic constituents of the twigs and leaves of Aglaia rubiginosa. J. Nat. Prod., 67: 343-347, 2004.

Jang, D.S., Cuendet, M., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2. J. Agric. Food Chem., 52: 2218-2222, 2004.

Shin, Y.G., Udeani, G.O., Kosmeder II, J.W., Zhao, G.-M., Dagar, S., Onyuksel, H.,

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Moriarty, R.M. Cordell, G.A., Moon, R.C., Kinghorn, A.D., and Pezzuto, J.M. Identification of degradation product of deguelin and its stability using liquid chromatography and electrospray/mass spectrometry. J. Liquid Chrom. Rel. Technol., 27: 1057-1069, 2004.

Hwang, B.Y., Su, B.-N., Chai, H., Mi, Q., Kardono, L.B.S., Afriastini, J.J., Riswan, S., Santarsiero, B.D., Mesecar, A.D., Wild, R., Fairchild, C.R., Vite, G.D., Rose, W.C., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J. Org. Chem., 69: 3350-3358, 2004.

Christov, K.T., Moon, R.C., Lantvit, D.D., Boone, C.W., Kelloff, G.J., Steele, V.E., Lubet, R.A., and Pezzuto, J.M. Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies. Eur. J. Cancer, 40: 1404-1411, 2004.

Chien, N.Q., Hung, N.V., Santarsiero, B.D., Mesecar, A.D., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., Fong, H.H., and Tan, G.T. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. J. Nat. Prod., 67: 994-998, 2004.

Li, Y., Grubjesic, S., Nikolic, D., Zhu, D., Kosmeder, J.W., Moriarty, R.M., Pezzuto, J.M., and van Breemen, R.B. In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica, 34: 535-547, 2004.

Gu, J.Q., Graf, T.N., Lee, D., Chai, H.B., Mi, Q., Kardono, L.B., Setyowati, F.M., Ismail, R., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Kroll, D.J., Falkinham, J.O. 3rd, Wall, M.E., Wani, M.C., Kinghorn, A.D., and Oberlies, N.H. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod., 67: 1156-1161, 2004.

Kinghorn, A.D., Su, B.-N., Jang, D.S., Chang, L.C., Lee, D., Gu, J., Carcache-Blanco, E.J., Pawlus, A.D., Lee, S.K., Park, E.J., Cuendet, M., Gills, J.J., Bhat, K., Park, H.S., Mata-Greenwood, E., Song, L.L., Jang, M., and Pezzuto, J.M. Natural inhibitors of carcinogenesis. Planta Med., 70: 691-705, 2004.

Hwang, B.Y., Su, B.N., Chai, H., Mi, Q., Kardono, L.B., Afriastini, J.J., Riswan, S., Santarsiero, B.D., Mesecar, A.D., Wild, R., Fairchild, C.R., Vite, G.D., Rose, W.C., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J. Org. Chem., 69: 6156, 2004.

Jang, D.S., Cuendet, M., Su, B.-N., Totura, S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2. Planta Med., 70: 893-896, 2004.

Gafner, S., Lee, S.K., Cuendet, M., Barthelemy, S., Vergnes, L., Labidalle, S., Mehta, R.G., Boone, C.W., and Pezzuto, J.M. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems. Phytochemistry, 65: 2849-2859, 2004.

Su, B.N., Jones, W.P., Cuendet, M., Kardono, L.B., Ismail, R., Riswan, S., Fong, H.H., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2. Phytochemistry, 65: 2861-2866, 2004.

Kondratyuk, T. and Pezzuto, J.M. Natural product polyphenols of relevance to human health. Pharm. Biol. (Suppl.), 41: 46-63, 2004.

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Tamez, P.A., Lantvit, D., Lim, E., and Pezzuto, J.M. Chemosensitizing action of cepharanthine with chloroquine against drug-resistant human malaria, Plasmodium falciparum. J. Ethnopharmacol., 98: 137-142, 2005.

Lobo-Echeverri, T., Rivero-Cruz, J.F., Su, B.-N., Chai, H.-B., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Soejarto, D.D., and Kinghorn, A.D.. Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in southern Florida. J. Nat. Prod., 68: 577-580, 2005.

Rivero-Cruz, J.F., Lezutekong, R., Lobo-Echeverri, T., Ito, A., Mi, Q., Chai, H.-B., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Morelli, I., and Kinghorn, A.D. Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in southern Florida. Phytother. Res., 19: 136-140, 2005.

Mi, Q., Lantvit, D., Reyes-Lim, E., Chai, H., Phifer, S.S., Wani, M.C., Wall, M.E. Tan, G.T., Cordell, G.A., Farnsworth, N.R., Kinghorn, A.D. and Pezzuto, J.M. Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis. Anticancer Res., 25: 779-788, 2005.

Zhang. H.J., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., Fong, H.H., and Tan, G.T. Sesquiterpenes and butenolides, natural anti-HIV constituents from Litsea verticillata. Planta Med., 71: 452-457, 2005.

Chow, A.W., Murillo, G., Yu, C., van Breemen, R.B., Boddie, A.W., Pezzuto, J.M., Das Gupta, T.K., and Mehta, R.G. Resveratrol inhibits rhabdomyosarcoma cell proliferation. Eur. J. Cancer Prev., 14: 351-356, 2005.

Eggler, A.L., Liu, G., Pezzuto, J.M., van Breemen, R.B., and Mesecar, A.D. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc. Natl. Acad. Sci. U S A, 102: 10070-10075, 2005.

Jang, D.S., Su, B.-N., Pawlus, A.D., Jones, W.P., Kleps, R.A., Bunyapraphatsara, N., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Limnophilaspiroketone, a highly oxygenated phenolic derivative from Limnophila geoffrayi. J. Nat. Prod., 68: 1134-1136, 2005.

Gills, J.J., Kosmeder III, J., Moon, R.C., Lantvit, D.D., and Pezzuto, J.M. Effect of deguelin on UVB-induced skin carcinogenesis. J. Chemother., 3: 297-301, 2005.

Jones, W.P., Lobo-Echiverri, T., Mi, Q., Chai, H., Lee, D., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Antitumor activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida. J. Pharm. Pharmacol., 57: 1101-1108.

Soejarto, D.D., Fong, H.H.S., Tan, G.T., Zhang, H.J., Ma, C.Y., Franzblau, S.G., Gyllenhaal, C., Riley, M.C., Kadushin, M.R., Pezzuto, J.M., Xuan, L.T., Hiep, N.T., Hung, N.V., Vu, B.M., Loc, P.K., Dac, L.X., Binh, L.T., Chien, N.Q., Hai, N.V., Bich, T.Q., Cuong, N.M., Southavong, B., Sydara, K., Bouamanivong, S., Ly, H.M., Tran Van Thuy, Rose, W.C., and Dietzman, G.R. Ethnobotany/Ethnopharmacology and mass bioprospecting: Issues on intellectual property and benefit-sharing. J. Ethnopharmacol., 100: 15-22, 2005.

Liu, G., Eggler, A.L., Dietz, B.M., Mesecar, A.D., Bolton, J.L., Pezzuto, J.M., and van Breemen, R.B. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal. Chem., 77: 6407-6414, 2005.

Lee, H.-Y., Oh, S.-H., Jin, Q., Woo, J.K., Kim, W.-Y., Van Pelt, C.S., Price, R.E., Cody,

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D., Tran, H., Pezzuto, J.M., Moriarty, R.M., and Hong, W.K. Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J. Natl. Cancer Inst., 97: 1695-1699, 2005.

He, Z.D., Ma, C.Y., Zhang, H.J., Tan, G.T., Tamez, P., Sydara, K., Bouamanivong, S., Southavong, B., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H. Antimalarial constituents from Nauclea orientalis (L.) L. Chem. Biodivers., 2: 1378-1386, 2005.

Zhang, H.-J., Ma, C., Hung, NV, Cuong, NM, Tan, G.T., Santarsiero, B.D., Mesecar, A.D., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Miliusanes, a class of cytotoxic agents from Miliusa sinensis. J. Med. Chem., 49: 693-708, 2006.

Homhual, S., Zhang, H.-J., Bunyapraphatsara, N., Kondratyuk, T.P., Santarsiero, B.D., Mesecar, A.D., Herunsalee, A., Chaukul, W., Pezzuto, J.M., and Fong, H.H.S. Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Med., 72: 255-260, 2006.

Homhual, S., Bunyapraphatsara, N., Kondratyuk, T.P., Herunsalee, A., Chaukul, W., Pezzuto, J.M., Fong, H.H.S., and Zhang, H.-J. Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. J. Nat. Prod., 69: 421-424, 2006.

Soejarto, D.D., Zhang, H.J., Fong, H.H.S., Tan, G.T., Ma, C.Y., Gyllenhaal, C., Riley, M.C., Kadushin, M.R., Franzblau, S.G., Bich, T.Q., Cuong, N.M., Hiep, N.T., Loc, P.K., Xuan, L.T., Hai, N.V., Hung, N.V., Chien, N.Q., Binh, L.T., Vu, B.M., Ly, H.M., Southavong, B., Sydara, K., Bouamanivong, S., Pezzuto, J.M., Rose, W., Dietzman, G., Miller, B., and Thuy, T.V. Studies on biodiversity of Vietnam and Laos, 1998-2005: Examining the impacts. J. Nat. Prod., 69: 473-481, 2006.

Cuendet, M., Oteham, C.P., Moon, R.C., and Pezzuto, J.M. Quinone reductase induction as a biomarker for cancer chemoprevention. J. Nat. Prod., 69: 460-463, 2006.

Fang, L., Ito, A., Chai, H.-B., Mi, Q., Jones, W.P., Madulid, D.R., Oliveros, M.B., Gao, Q., Orjala, J., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Swanson, S.M., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines. J. Nat. Prod., 69: 332-337, 2006.

Carcache-Blanco, E.J., Cuendet, M., Park, E.J., Su, B.-N., Rivero-Cruz, J.F., Farnsworth, N.R. Pezzuto, J.M., and Kinghorn, A.D. Potential cancer chemopreventive agents from Arbutus unedo. Nat. Prod. Res., 20: 327-334, 2006.

Gills, J.J., Jeffery, E.H., Matusheski, N.V., Moon, R.C., Lantvit, D.D., and Pezzuto, J.M. Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett., 236: 72-79, 2006.

Wright, A.D., de Nys, R., Angerhofer, C.K., Pezzuto, J.M., and Gurrath, M. Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. J. Nat. Prod., 69:1180-1187, 2006.

Jang, D.S., Su, B.N., Pawlus, A.D., Kang, Y.H., Kardono, L.B., Riswan, S., Afriastini, J.J., Fong, H.H., Pezzuto, J.M., and Kinghorn, A.D. Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. Phytochemistry, 67: 1832-1837, 2006.

He, Z.D., Ma, C.Y., Tan, G.T., Sydara, K., Tamez, P., Southavong, B., Bouamanivong, S., Soejarto, D.D., Pezzuto, J.M., Fong, H.H., and Zhang, H.J. Rourinoside and rouremin, antimalarial constituents from Rourea minor. Phytochemistry, 67:1378-1384, 2006.

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Choi, J.K., Murillo, G., Su, B.N., Pezzuto, J.M., Kinghorn, A.D., and Mehta, R.G. Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J., 273: 5714-5723, 2006.

Thole, J.M., Kraft, T.F., Sueiro, L.A., Kang, Y.H., Gills, J.J., Cuendet, M., Pezzuto, J.M., Seigler, D.S., and Lila, M.A. A comparative evaluation of the anticancer properties of European and American elderberry fruits. J. Med. Food, 9: 498-504, 2006.

Balunas, M.J., Jones, W.P., Chin, Y.W., Mi, Q., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Swanson, S.M., Pezzuto, J.M., Chai, H.B., and Kinghorn, A.D. Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project. Chem Biodivers., 3: 897-915, 2006.

Cuendet, M., Mesecar, A.D., Dewitt, D.L. and Pezzuto, J.M. Cyclooxygenase (Cox 1 & 2) activity assays. Nature Protocols . 1: 1922-1928, 2006.

Williams, P.G., Asolkar, R.N., Kondratyuk, T., Pezzuto, J.M., Jensen, P.R., and Fenical, W. Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J. Nat. Prod., 70: 83-88, 2007.

Maiti, A., Cuendet, M., Kondratyuk, T., Croy, V.L., Pezzuto, J.M., and Cushman, M. Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J. Med. Chem., 50: 350-355, 2007.

Murillo, G., Hirschelman, W.H., Ito, A., Moriarty, R.M., Kinghorn, A.D., Pezzuto, J.M., and Mehta, R.G. Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. Nutr. Cancer, 57: 28-37, 2007.

Maiti, A., Cuendet, M., Croy, V.L., Endringer, D.C., Pezzuto, J.M., and Cushman, M. Synthesis and biological evaluation of (±)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. J. Med. Chem., 50: 2799-2806, 2007.

Jutiviboonsuk, A., Zhang, H.-J., Kondratyuk, T.P., Herunsalee, A., Chaukul, W., Pezzuto, J.M., Fong, H.H.S., and Bunyapraphatsara, N. Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae. Pharm. Biol., 45: 185-194, 2007.

Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, Breemen RB. Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry. Anal. Chem., 79: 9398-9402, 2007.

Endringer, D.C., Pezzuto, J.M., Soares, C.M., and Braga, F.C. L-(+)-Bornesitol. Acta Crystallogr. Sect. E Struct. Rep. Online, 63: 1067-1068, 2007.

Guo J, Liu D, Nikolic D, Zhu D, Pezzuto JM, van Breemen RB. In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab. Dispos., 36: 461-468, 2008.

Guo, J., Liu, A., Cao, H., Luo, Y., Pezzuto, J.M., and van Breemen RB. Biotransformation of the chemopreventive agent isoliquiritigenin by UDP-glucuronosyltransferases. Drug Metab. Dispos., 36: 2104-2112, 2008.

Endringer, D.C., Guimarães, K.G., Kondratyuk, T.P., Pezzuto, J.M., and Braga, F.C.

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Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. J. Nat. Prod., 71: 1082-1084, 2008.

Pezzuto, J.M. Grapes and human health: A perspective. J. Agric. Food Chem., 56: 6777-6784, 2008.

Guilford, J.M. and Pezzuto, J.M. Natural products as inhibitors of carcinogenesis. Expert Opin. Investig. Drugs. 17: 1341-1352, 2008.

Cuendet, M., Oteham, C.P., Moon, R.C., Keller, W.J., Peaden, P.A., and Pezzuto, J.M. Dietary administration of Asimina triloba (paw paw) extract increases tumor latency in N-methyl-N-nitrosourea-treated rats. Pharm. Biol., 46: 3-7, 2008.

Topcu, G., Turkmen, Z., Schilling, J.K., Kingston, D.G.I., Pezzuto, J.M., and Ulubelen, A. Cytotoxic activity of some anatolian Salvia extracts and isolated abietane diterpenoids. Pharm. Biol., 46: 180-184, 2008.

Francy-Guilford, J. and Pezzuto, J.M. Mechanisms of cancer chemopreventive agents: A perspective. Planta Med., 74: 1644-1650, 2008.

Cuendet, M., Oteham, C.P., Maiti, A., Craig, B.A., Cushman, M., Moon, R.C., and Pezzuto, J.M. Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion. Anticancer Res, 28: 3705-3709, 2008.

Pezzuto, J.M. Resveratrol as an Inhibitor of Carcinogenesis. Pharm. Biol., 46: 443-573, 2008.

Pezzuto, J.M., Venkatasubramanian, V., Hamad, M., and Morris, K.R. Unraveling the relationship between grapes and health. J. Nutr., 139: 1783S-1787S, 2009.

Asolkar, R.N., Freel, K.C., Jensen, P.R., Fenical, W., Kondratyuk, T.P., Park, E.J., and Pezzuto, J.M. Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola. J. Nat. Prod., 72: 396-402, 2009.

Kang, S.S., Cuendet, M., Endringer. D.C., Croy, V.L., Pezzuto, J.M., and Lipton, M.A. Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. Bioorg. Med. Chem., 17:1044-1054, 2009.

Deng, Y., Balunas, M.J., Kim, J.A., Lantvit, D.D., Chin, Y.W., Chai, H., Sugiarto, S., Kardono, L.B.S., Fong, H.H.S., Pezzuto, J.M., Swanson, S.M., Carcache de Blanco, E.J., and Kinghorn, A.D. Bioactive 5,6-Dihydropyrone Derivatives from Hyptis brevipes. J. Nat. Prod., 72: 1165-1169, 2009.

Maiti, A., Reddy, P.V., Sturdy, M., Marler, L., Pegan, S.D., Mesecar, A.D., Pezzuto, J.M., and Cushman, M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J. Med. Chem., 52: 1873-1884, 2009.

Ghufran, M.A., Qureshi, R.A., Batool, A., Kondratyuk, T.P., Guilford, J.M., Marler, L.E., Chang, L.C., and Pezzuto, J.M. Evaluation of selected indigenous medicinal plants from the Western Himalayas for cytotoxicity and as potential cancer chemopreventive agents. Pharm. Biol., 47: 533-538, 2009.

Yao, G., Kondratyuk, T.P., Tan, G.T., Pezzuto, J.M., and Chang, L.C. Bioactive sulfated sesterterpene alkaloids and sesterterpene sulfates from the marine sponge Fasciospongia sp.

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Mi, Q., Pezzuto, J.M., Farnsworth, N.R., Wani, M.C., Kinghorn, A.D., and Swanson, S.M. Use of the in vivo hollow fiber assay in natural products anticancer drug discovery (#). J. Nat. Prod., 72: 573-580, 2009.

Endringer, D.C., Pezzuto, J.M., and Braga, F.C. NF-κB inhibitory activity of cyclitols isolated from Hancornia speciosa. Phytomedicine, 16: 1064-1069, 2009.

Balunas, M.J., Su, B., Riswan, S., Fong, H.H., Brueggemeier, R.W., Pezzuto, J.M., and Kinghorn, A.D. Isolation and characterization of aromatase inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett., 2: 29-33, 2009.

Schupp, P.J., Kohlert-Schupp, C., Whitefield, S., Engemann, A., Rohde, S., Hemscheidt, T., Pezzuto, J.M., Kondratyuk, T.P., Park, E.J., Marler, L., Rostama, B., and Wright, A.D. Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam. Nat Prod Commun., 4: 1717-1728, 2009.

Endringer, D.C., Valadares, Y.M., Campana, P.R., Campos, J.J., Guimarães, K.G., Pezzuto, J.M., and Braga, F.C. Evaluation of Brazilian plants on cancer chemoprevention targets in vitro. Phytother. Res., 29: 928-933, 2010.

Yang, J.H., Kondratyuk, T.P., Marler, L.E., Qiu, X., Choi, Y., Cao, H., Yu, R., Sturdy, M., Pegan, S., Liu, Y., Wang, L.Q., Mesecar, A.D., van Breemen, R.B., Pezzuto, J.M., Fong, H.H., Chen, Y.G., and Zhang, H.J. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry, 71: 641-647, 2010.

Cuendet, M., Guo, J., Luo, Y., Chen, S., Oteham, C.P., Moon, R.C., van Breemen, R.B., Marler, L.E., and Pezzuto, J.M. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev. Res., 3: 221-232, 2010.

Morais, M.C., Luqman, S., Kondratyuk, T.P., Petronio, M.S., Regasini, L.O., Silva, D.H., Bolzani, V.S., Soares, C.P., and Pezzuto, J.M. Suppression of TNF-alpha induced NFkappaB activity by gallic acid and its semi-synthetic esters: Possible role in cancer chemoprevention. Nat. Prod. Res., 24: 1758-1765, 2010.

Calamini, B., Ratia, K., Malkowski, M., Cuendet, M., Pezzuto, J.M., Santarsiero, B.D., and Mesecar, A.D. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem. J., 429: 273-282, 2010.

Cheenpracha, S., Park, E.J., Rostama, B., Pezzuto, J.M., and Chang, L.C. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells by the norsesterterpene peroxide, epimuqubilin A. Mar. Drugs, 8: 429-437, 2010.

Nam, S-J, Gaudêncio, S.P., Maloney, K.N., Kauffman, C.A., Jensen, PR., Kondratyuk, T.P., Marler, L.E., Pezzuto, J.M., and Fenical, W. Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-eerived sediment bacterium of the genus Nocardiopsis. J. Nat. Prod., 73: 1080-1086 2010.

Luqman, S. and Pezzuto, J.M. NFκB: A promising target for natural products in cancer chemoprevention. Phytother. Res., 24: 949-963, 2010 (invited review).

Sun, B., Hoshino, J., Jermihov, K., Marler, L., Pezzuto, J.M., Mesecar, A.D., and

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Cushman, M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg. Med. Chem., 18: 5352-5366, 2010.

Hoshino, J., Park, E.J., Kondratyuk, T.P., Marler, L., Pezzuto, J.M., and Cushman, M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J. Med. Chem., 53: 5033-5043, 2010.

Gullett, N.P., Ruhul Amin, A.R., Bayraktar, S., Pezzuto, J.M., Shin, D.M., Khuri, F.R., Aggarwal, B.B., Surh, Y.J., and Kucuk, O. Cancer prevention with natural compounds. Semin. Oncol., 37: 258-281, 2010.

Cheenpracha, S., Park, E.J., Yoshida, W.Y., Barit, C., Wall, M., Pezzuto, J.M., and Chang, L.C. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg. Med. Chem., 18: 6598-6602, 2010.

Conda-Sheridan, M., Marler, L., Park, E.J., Kondratyuk, T.P., Jermihov, K., Mesecar, A.D., Pezzuto, J.M., Asolkar, R.N., Fenical, W., and Cushman, M. Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, Strain CNS284. J. Med. Chem., 53: 8688-8699, 2010.

Marler, L., Conda-Sheridan, M., Cinelli, M.A., Morrell, A.E., Cushman, M., Chen, L., Huang, K., van Breemen, R., and Pezzuto, J.M. Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Res., 30: 4873-4882, 2010.

Choi, Y., Jermihov, K., Nam, S.J., Sturdy, M., Maloney, K., Qiu, X., Chadwick, L.R., Main, M., Chen, S.N., Mesecar, A.D., Farnsworth, N.R., Pauli, G.F., Fenical, W., Pezzuto, J.M., and van Breemen, R.R. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal. Chem., 83: 1048-1052, 2011.

Yang, J.H., Kondratyuk, T.P., Jermihov, K.C., Marler, L.E., Qiu, X., Choi, Y., Cao, H., Yu, R., Sturdy, M., Huang, R., Liu, Y., Wang, L.Q., Mesecar, A.D., van Breemen, R.B., Pezzuto, J.M., Fong, H.H., Chen, Y.G., and Zhang, H.J. Bioactive compounds from the fern Lepisorus contortus. J. Nat. Prod., 74: 129-136, 2011.

Pezzuto, J.M. The phenomenon of resveratrol: redefining the virtues of promiscuity. Ann. NY Acad. Sci., 1215: 123-130, 2011.

Zou, J., Pan, L., Li, Q., Zhao, J., Pu, J., Yao, P., Gong, N., Lu, Y., Kondratyuk, T.P., Pezzuto, J.M., Fong, H.H., Zhang, H., and Sun, H.. Rubesanolides A and B: Diterpenoids from Isodon rubescens. Org. Lett., 13: 1406-1409, 2011.

Park, E-J, Kondratyuk, T.P., Morrell, A., Kiselev, E., Conda-Sheridan, M., Cushman, M., Ahn, S., Choi, Y., White, J.J., van Breemen, R.B., and Pezzuto, J.M. Induction of retinoid X receptor activity and consequent up-regulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells. Cancer Prev. Res., 4: 592-607, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr. Cancer, 63: 971-982, 2011.

Kondratyuk, T.P., Park, E.J., Marler, L.E., Ahn, S., Yuan, Y., Choi, Y., Yu, R., van

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Breemen, R.B., Sun, B., Hoshino, J., Cushman, M., Jermihov, K.C., Mesecar, A.D., Grubbs, C.J., and Pezzuto, J.M. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol. Nutr. Food Res., 55: 1249-1265, 2011.

Vang, O., Ahmad, N., Baile, C.A., Baur, J.A., Brown, K., Csiszar, A., Das, D.K., Delmas, D., Gottfried, C., Lin, H.Y., Ma, Q.Y., Mukhopadhyay, P., Nalini, N., Pezzuto, J.M., Richard, T., Shukla, Y., Surh, Y.J., Szekeres, T., Szkudelski, T., Walle, T., and Wu, J.M. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One, 6: e19881, 2011.

Luqman, S., Meena, A., Marler, L.E., Kondratyuk, T.P., and Pezzuto, J.M. Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine. J. Med. Food, 14: 1344-1351, 2011.

Park, E.J., Kiselev, E., Conda-Sheridan, M., Cushman, M., and Pezzuto, J.M. Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells. J. Nat. Prod. 75: 378-384, 2012.

Park, E.J., Cheenpracha, S., Chang, L.C., and Pezzuto, J.M. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem. Lett., 4: 426-431, 2011.

Shen, L., Park, E.J., Kondratyuk, T.P., Guendisch, D., Marler, L., Pezzuto, J.M., Wright, A.D., and Sun, D. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg. Med. Chem., 19: 6182-6195, 2011.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.J., Pezzuto, J.M., and Cushman, M. Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorg. Med. Chem. 20: 510-520, 2012.

Guilford, J.M. and Pezzuto, J.M. Wine and health: A review Am. J. Enol. Vitic. 62: 471-486, 2011.

Guilford, J.M. and Pezzuto, J.M. (2011). Cancer Chemoprevention, in Phytochemistry and Pharmacognosy, edited by M.J. Kato and J.M. Pezzuto, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net]

Kato, M.J. and Pezzuto, J.M. (2011). Phytochemistry and Pharmacognosy, in Phytochemistry and Pharmacognosy, edited by M.J. Kato and J.M. Pezzuto, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net]

Kondratyuk, T.P., Park, E.-J., Yu, R., van Breemen, R.B., Asolkar, R.N., Murphy, B.T., Fenical, W., and Pezzuto, J.M. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents Mar. Drugs 2012, 10(2), 451-464; doi:10.3390/md10020451.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorg. Med. Chem., 20: 2427-2434, 2012.

Park, E.-J., Pezzuto, J.M., Jang, K.W., Nam, S.-J., Bucarey, S.A., and Fenical, W. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat. Prod. Commun., 6: 789-794, 2012.

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Park, E-J and Pezzuto, J.M. Flavonoids in cancer prevention. Anti-Cancer Agents Med. Chem., 12: 836-851, 2012.

Chen, L., Conda-Sheridan, M., Reddy, P.V.N., Morrell, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., van Breemen, R.B., and Cushman, M. Identification, Synthesis, and Biological evaluation of the metabolites of 3-amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6−36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. J. Med. Chem., 55: 5965-5981, 2012.

Youn, U.J., Park, E.-J., Kondratyuk, T.P., Simmons, C.J., Borris, R.P., Tanamatayarat, P., Wongwiwatthananukit, S., Toyama, O., Songsak, T., Pezzuto, J.M., and Chang, L.C. Anti-inflammatory sesquiterpene lactones from the flowers of Vernonia cinerea. Bioorg. Med. Chem. Lett. 22: 5559-5562, 2012.

Kondratyuk, T.P. and Pezzuto, J.M. (2012). Chemistry and biological activity of grapes, in Nutraceuticals and Functional Foods, edited by G. K. Jayaprakasha, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net]

Archer, C.R., Groll, M., Stein, M.L., Schellenberg, B. Clerc, J., Kaiser, M., Kondratyuk, T.P., Pezzuto, J.M., Dudler, R., and Bachmann, A.S. Activity enhancement of the synthetic syrbactin proteasome 2 inhibitor hybrid and biological evaluation in tumor cells. Biochemistry, 51: 6880-6888, 2012.

Yu, X., Park, E.-J., Kondratuk, T.P., Pezzuto, J.M., and Sun, D. Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors. Org. Biomol. Chem. 10: 8835-8847, 2012.

Carlson, S., Marler, L., Nam, S.J., Santarsiero, B.D. Pezzuto, J.M., and Murphy, B.T. Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp. Marine Drugs 2013, 11(4), 1152-1161; doi:10.3390/md11041152.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M. Optimizing thiadiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). Bioorg. Med. Chem. 20: 7030-7039, 2012.

Luqman, S., Meena, A., Singh, P., Kondratyuk, T.P., Marler, L.E., Pezzuto, J.M., Negi. A.S. Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents. Chem. Biol. Drug Des. 80: 616-624, 2012.

Sun, D., Hurdle, J.G., Lee, R.E., Lee, R.E., Cushman, M., Pezzuto, J.M. Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. Chem. Med. Chem. 7: 1541-1545, 2012.

Chen, L., Conda-Sheridan, M., Reddy, P.V., Morrell, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., van Breemen, R.B., and Cushman, M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. J. Med. Chem. 55: 5965-5981, 2012.

Ihsan-ul-Haq, Mirza, B., Kondratyuk, T.P., Park, E.-J., Burns, B.E., Marler, L.E., and Pezzuto, J.M. Preliminary evaluation of the cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants from Pakistan. Pharm. Biol., 51:316-328, 2013.

Conda-Sheridan, M., Park, E.-J., Beck, D.E., Reddy, P.V.N., Nguyen, T.X., Hu, B., Chen, L., White, J.J., van Breemen, R.B., Pezzuto, J.M., and Cushman, M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential J. Med. Chem. 56: 2581-2605, 2013.

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Park, E.-J. and Pezzuto, J.M Antioxidant marine products in cancer chemoprevention Antiox. Redox. Signaling 19: 115-138: 2013 (forum issue on “Antioxidants in Cancer Prevention”).

Ogas, T., Kondratyuk, T.P., and Pezzuto, J.M. Resveratrol analogs: promising chemopreventive agents. Annals NY Acad. Sci. 1290: 21-29, 2013.

Pezzuto, J.M., Kondratyuk, T.P., and Olgas, T. Resveratrol derivatives: A patent review (2009-2012). Expert Opinion Therapeutic Patents 23: 1529-1546, 2013.

Andreani, A., Leoni, A., Locatelli, A., Morigi, R., Rambaldi, M., Cervellati, R., Greco, E., Kondratyuk, T.P., Park, E.-J., Huang, K., van Breemen, R.B., and Pezzuto, J.M. Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. Eur. J. Med. Chem., 68: 412-421, 2013.

Pansanit, A., Park, E.-J., Kondratyuk, T.P., Pezzuto, J.M., Lirdprapamongkol, K., and Prasat Kittakoop, P. Vermelhotin, an anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 cells via p38 inhibition. J. Nat. Prod., 76: 1824-1827, 2013.

Endringer, D.C., Taveira, F.S.N., Kondratyuk, T.P., Pezzuto, J.M., and Braga, F.C. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium. Rev. Bras. Farmacogn. 24: 408-412, 2014.

Pan, W., Liu, K., Guan, Y., Tan, G.T., Hung, N.V., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., Fong, H.H.S., and Zhang, H. Bioactive Compounds from Vitex leptobotrys. J. Nat. Prod., 77(3):663-667, 2014.

Park, E.-J., Shen, L., Sun, D. and Pezzuto, J.M. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J. Nat. Prod., 77(3):527-535. 2014.

Andreani, A., Leoni, A., Locatelli, A., Morigi, R., Rambaldi, M., Cervellati, R., Greco, E., Kondratyuk, T.P., Park, E.-J., Huang, K., van Breemen, R.B., and Pezzuto, J.M. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives. Eur. J. Med. Chem., 82:68-81, 2014.

Parrish, S., Yoshida, W., Kondratyuk, T. P., Park, E.-J., Pezzuto, J.M., Kelly, M., and Williams, P. Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. J. Nat. Prod., 77:1644-1649, 2014.

Pezzuto, J.M. and Pezzuto, M.F. Academic pharmacy strikes Hawaii (Part 1). Hawaii J. Med. Public Health 74: 33-36, 2015.

Pezzuto, J.M. and Ma, C.S.J. Academic pharmacy strikes Hawaii (Part 2). Hawaii J. Med. Public Health 74: 120-128, 2015.

Park, E.-J and Pezzuto, J.M. The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta, 1852: 1071-1113, 2015.

Jabeen, F., Panda, S.S., Kondratyuk, T.P., Park, E.J., Pezzuto, J.M., Ihsan-UL-Haq, Hall, C.D., Katritzky, A.R. Synthesis, molecular docking and anticancer studies of peptides and iso-peptides. Bioorg. Med. Chem. Lett. 25: 2980-2984, 2015.

Hussain, R.A., Badshah, A., Pezzuto, J.M., Ahmed, N., Kondratyuk, T.P., Park, E.J. Ferrocene incorporated selenoureas as anticancer agents. J. Photochem. Photobiol. B 148:197-208, 2015.

Chelsky, Z., Kondratyuk, T.P., Pezzuto, J.M., Cushman, M. and Turkson, J. A resveratrol analogue promotes ERKMAPK-dependent Stat3 serine and tyrosine phosphorylation alterations and antitumor effects in vitro against human tumor cells, Mol. Pharmacol. 88: 524-533, 2015.

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Cragg, G.M and Pezzuto, J.M. Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. Med. Principles Pract. 25, Suppl. 2, 2016 (in press). DOI:10.1159/000443404.

Youn,U.J., Sripisut, T., Park, E.J., Kondratyuk, T.P., Fatima, N., Simmons, C.J., Wall, M.S., Sun, D., Pezzuto, J.M., and Chang, L.C. Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg. Med. Chem. Lett., 25: 4719-4723, 2015.

Fatima, N., Kondratyuk, T.P., Park, E.-J., Marler, L.E., Jadoon, M., Qazi, M.A., Khan, I., Atiq, N., Chang, L.C., Pezzuto, J.M. and Ahmed, S. Cancer chemopreventive and antimicrobial activity of endophytic fungi isolated from Taxus baccata. Pharm. Biol. DOI:10.3109/13880209.2016.1170154 (in press).

Kondratyuk, T.P., Adrian, J.A.L., Wright, B., Park, E.-J., van Breemen, R.B., Morris, K.R., and Pezzuto, J.M. Evidence supporting the conceptual framework of cancer chemoprevention in canines. Nature-Scientific Reports, 6, 26500; doi: 10.1038/srep26500 (2016).

Park, E.-J., Sang-Ngern, M., Chang, L.C. and Pezzuto, J.M. Induction of G0/G1 cell cycle arrest with down-regulation of Hsp90 client proteins and histone modification by 4β-hydroxywithanolide isolated from Physalis peruviana. Mol. Nutr. Food Res. 60: 1482-1500, 2016 (featured on the cover).

Sang-ngern, M., Youn, U. J., Park, E-J., Kondratyuk, T.P., Simmons, C.J., Wall, M. M., Ruf, M., Lorch, S.E., Pezzuto, J.M., and Chang, L.C. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. J. Nat. Prod., 2016 (in press).

Khan, S.Z., Amir, M.K., Ullah, I., Aamir, A., Pezzuto, J.M., Kondratyuk, T.P., Belanger-Gariepy, F., Ali, A., Khan, S., Rehman, Z. New heteroleptic palladium (II) dithiocarbamates: synthesis, characterization, packing and anticancer activity against five different cancer cell lines. Applied Organometallic Chem., 2016 (in press).

Issaa, M.E., Berndta, S., Carpentierb, G., Pezzuto, J.M. and Cuendet, M. Bruceantin inhibits multiple myeloma cancer stem cell proliferation. Cancer Biology & Therapy, 2016 (in press).

Articles Submitted/Actively In Preparation

Jafri, L., Saleem, S., Kondrytuk, T.P., ul-Haqd, I., Nazif ullah, Pezzuto, J.M. Hedera nepalensis K. Koch: a novel source of natural cancer chemopreventive and anticancerous compounds. Phytomedicine, 2016 (submitted).

Saleem, S., Kondrytuk, T.P., Park, E-J., Pezzuto, J.M., Mirza, B. A pentacyclic triterpenoid acid and its glycosidic derivatives from Fagonia cretica L. induce cell cycle arrest and apoptosis in breast cancer cells via p53, BAX and γ-H2AX genes. J. Ethnopharmacol., 2016 (submitted).

Youn, U.J., Kondratyuk, T.P., Park, E.-J., Sripisut, T., Laphookhieo, S., Pezzuto, J.M. and Chang. L.C. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. J. Nat. Prod., submitted.

Parimelazhagan, T., Kondratyuk, T.P., Park. E.-J., Murugan, R., Pezzuto, J.M., Christopher, A.B., Gachomo, E.W., and Kotchoni, S.O. Inhibition of nitric oxide and free radicals production by leaf and stem extracts of Psychotria nilgiriensis. J. Ethnopharmacol., submitted.

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Book Chapters

Yang, C.S. and Pezzuto, J.M. Nuclear Aryl Hydrocarbon Hydroxylase and Its Role in the Activation of Benzo(a)pyrene. In: P.W. Jones and P. Leber (eds.), Polynuclear Aromatic Hydrocarbons, pp. 653-667. Ann Arbor Science Publishers, 1979.

Pezzuto, J.M. and Phoebe, Jr., C.H. "Laboratory Text in Pharmacognosy 233." Published by the Authors, 37 pp., 1982.

Farnsworth, N.R. and Pezzuto, J.M. Practical Pharmacologic Evaluation of Plants. In: Pharmacological Screening of Plants and Natural Substances. No. 13, pp. 138-160. International Foundation for Science, Stockholm, 1983.

Farnsworth, N.R. and Pezzuto, J.M. Rational Approaches to the Development of Plant-Derived Drugs. In: Proceedings of the Second National Symposium of Natural Products Pharmacology and Chemistry, Nov. 3-5, 1983, Joao Pessoa, Brazil, pp. 35-63. University Editors, Federal University of Paraiba, 1984.

Farnsworth, N.R. and Pezzuto, J.M. Practical Pharmacologic Evaluation of Plants. In: B. Conyers (ed.), Bulletin 21 of the Air Chief Marshal the Lord Dowding Fund for Humane Research, pp. 26-34. National Anti-Vivisection Society Limited, London, 1984 (reprinted from a paper presented at the University of Panama).

Pezzuto, J.M. Chemistry, Metabolism and Biological Activity of Steviol (ent-13-Hydroxykaur-16-en-19-oic Acid), the Aglycone of Steviol. In: Atta-ur-Rahman and P.W. LeQuesne (eds.), New Trends in Natural Products Chemistry. 1986. Studies in Organic Chemistry, Vol. 26, pp. 371-386. Elsevier Scientific Publishers, 1986.

Swanson, S.M. and Pezzuto, J.M. Bioscreening for Antitumor Activity: Evaluation of Cytotoxic Potential and Ability to Inhibit Macromolecule Biosynthesis. In: E.B. Thompson (ed.), Drug Bioscreening. Drug Evaluation Techniques in Pharmacology, pp. 273-297. New York: VCH Publishers, 1990.

Suffness, M. and Pezzuto, J.M. Assays for Cytotoxicity and Antitumor Activity, Chapter 4. In: K. Hostettmann (ed.), Methods in Plant Biochemistry, Vol. 6, pp. 71-133. London: Academic Press, 1991.

Cordell, G.A., Pezzuto, J.M., Hamburger, M.O., Gunawardana, Y.A.G.P., Shieh, H.-L., and McPherson, D.D. Recent Studies on Anticancer Agents. In: Progress in Chemistry of Medicinal Plants in Asia. Proceedings of the Sixth Asian Symposium on Medicinal Plants and Spices, pp. 243-254, Bandung, Indonesia, 1989.

Cordell, G.A., Beecher, C.C.W., and Pezzuto, J.M. Can Ethnopharmacology Contribute to the Development of New Anticancer Drugs? Proceedings of the First International Congress on Ethnopharmacology, Strasbourg, France, June 5-9, 1990.

Angerhofer, C.K., König, G.M., Wright, A.D., Sticher, O., Milhous, W.K., Cordell, G.A., Farnsworth, N.R., and Pezzuto, J.M. Selective Screening of Natural Products: A Resource for the Discovery of Novel Antimalarial Compounds. In: Atta-ur-Rahman (ed.), Advances in Natural Product Chemistry, pp. 311-329, Harwood Academic Publishers: Chur, Switzerland, 1992.

Tan, G.T., Pezzuto, J.M., and Kinghorn, A.D. Screening of Natural Products as HIV-1 and

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HIV-2 Reverse Transcriptase (RT) Inhibitors. In: C.K. Chu and H. Cutler (eds.), Natural Products as Antiviral Agents, pp. 195-222, New York: Plenum Press, 1992.

Angerhofer, C.K. and Pezzuto, J.M. Applications of Biotechnology for Drug Discovery and Evaluation. In: J.M. Pezzuto, M.E. Johnson, and H.R. Manasse, Jr. (eds.), Biotechnology and Pharmacy, pp. 312-365, New York: Chapman and Hall, 1993.

Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Separation, Structure Elucidation and Bioassay of Cytotoxic Natural Products. In: S.M. Colegate and R.J. Molyneux (eds.), Bioactive Natural Products: Detection, Isolation and Structural Identification, pp. 195-219, Boca Raton: CRC Press, 1993.

Angerhofer, C.K., König, G.M., Wright, A.D., Sticher, O., Milhous, W.K., Cordell, G.A., Farnsworth, N.R., and Pezzuto, J.M. Selective Screening of Natural Products: A Resource for the Discovery of Novel Antimalarial Compounds. In: Atta-ur-Rahman (ed.), New Trends in Natural Products Chemistry, pp. 431-443, 1993.

Cordell, G.A., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D., Kinghorn, A.D., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J.A., Tait, R.M., and Harris, T.J.R. Novel Strategies for the Discovery of Plant-Derived Anticancer Agents. In: A.D. Kinghorn and M.F. Balandrin (eds.), Human Medicinal Agents from Plants (ACS Symposium Series No. 534), pp. 191-204, American Chemical Society Books: Washington, 1993.

Pezzuto, J.M. Cancer Chemopreventive Agents: From Plant Materials to Clinical Intervention Trials. In: A.D. Kinghorn and M.F. Balandrin (eds.), Human Medicinal Agents from Plants (ACS Symposium Series No. 534), pp. 205-217, American Chemical Society Books: Washington, 1993.

Cordell, G.A., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D., Kinghorn, A.D., Pezzuto, J.M., Wall, M.E., Wani, M.C., Cobb, R.R., Harris, T.J.R., O'Neill, M.J., and Tait, R.M. Novel Strategies for the Discovery of Plant-Derived Anticancer Agents. In: F.A. Valeriote, T.H. Corbett, and L.H. Baker (eds.), Anticancer Drug Discovery and Development: Natural Products and New Molecular Models (Proceedings of the Second Symposium on Anticancer Drug Discovery and Development, Traverse City, Michigan, June 27-29, 1991), pp. 63-83, Boston: Kluwer Academic Publishers, 1994.

Pisha, E. and Pezzuto, J.M. Fruits and Vegetables Containing Compounds that Demonstrate Pharmacological Activity in Humans. In: N.R. Farnsworth and H. Wagner (eds.), Economic and Medicinal Plant Research. Vol. 6, pp. 189-233, London: Academic Press, 1994.

Shamon, L. and Pezzuto, J.M. Plant Antimutagens: A Review and Strategy for the Identification of Therapeutically Useful Agents. In: N.R. Farnsworth and H. Wagner (eds.), Economic and Medicinal Plant Research. Vol. 6, pp. 235-297, London: Academic Press, 1994.

Topçu, G., Öksüz, S. Johannson, C.B., Shieh, H.-L., Cordell, G.A., and Pezzuto, J.M. Active Constituents of Turkish Inula Species. In: Atta-ur-Rahman (ed.), New Trends in Natural Products Chemistry.

Cordell, G.A., Angerhofer, C.K., and Pezzuto, J.M. Recent Studies on Cytotoxic, Anti-HIV and Antimalarial Agents from Plants. Pure & Appl. Chem., 66: 2283-2286, 1994.

Pezzuto, J.M. Natural Product Cancer Chemopreventive Agents. In: J.T. Arnason, R. Mata, and J.T. Romeo (eds.), Recent Advances in Phytochemistry, Vol. 29, Phytochemistry of Medicinal Plants, pp. 19-45, New York: Plenum Press, 1995.

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Marles, R.J., Pazos-Sanou, L., Compadre, C.M., Pezzuto, J.M., Droódó, B., and Arnason, J.T. Sesquiterpene Lactones Revisited: Recent Developments in the Assessment of Biological Activities and Structure Relationships. In: J.T. Arnason, R. Mata, and J.T. Romeo (eds.), Recent Advances in Phytochemistry, Vol. 29, Phytochemistry of Medicinal Plants, pp. 333-356, New York: Plenum Press, 1995.

Tan, G.T. and Pezzuto, J.M. Anti-cancer Alkaloids. In: M.S. Blum (ed.), Chemistry and Toxicology of Diverse Classes of Alkaloids, pp. 1-119, Fort Collins: Alaken, Inc., 1996.

Cordell, G.A., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., Chai, H.-B., Constant, H.L., Likhitsitayawuid, K., Shieh, H.-L., Wikramaratne, D.B.M., and You, M. Recent Studies on Biologically Active Natural Products. In: Atta-ur-Rahman and M. Iqbal (eds.), New Trends in Natural Product Chemistry, pp. 57-78, Harwood Academic Publishers: Chur, Switzerland, 1998.

Pezzuto, J.M., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Mehta, R.G., Moon, R.C., Hedayat, S., Udeani, G.O., Moriarty, R.M., and Kinghorn, A.D. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. In: Atta-ur-Rahman and M. Iqbal (eds.), New Trends in Natural Product Chemistry, pp. 95-107, Harwood Academic Publishers: Chur, Switzerland, 1998.

Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, W.C., Brown, D.M., O'Neill, M., Lewis, J.A., and Besterman, J.M. Novel Strategies for the Discovery of Plant-derived Anticancer Agents. In: Atta-ur-Rahman and M. Iqbal (eds.), New Trends in Natural Product Chemistry, pp. 79-94, Harwood Academic Publishers: Chur, Switzerland, 1998.

Cordell, G.A., Beecher, C.W.W., Kinghorn, A.D., Pezzuto, J.M., Constant, H.L., Fang, L., Seo, E.-K., Long, L., Cui, B., Slowing-Barillas, K. The Dereplication of Natural Products. In: Atta-ur-Rahman (ed.), Studies in Natural Products Chemistry, Vol. 19, pp. 749-791, Amsterdam: Elsevier Science Publishers, 1997.

Pezzuto, J.M., Angerhofer, C.K., and Mehdi, H. In Vitro Models of Human Disease States. In: Atta-ur-Rahman (ed.), Studies in Natural Products Chemistry, Vol. 20. Structure and Chemistry (Part F), Amsterdam: Elsevier Science Publishers, pp. 507-560, 1998.

Pezzuto, J.M., Song, L.L., Lee, S.K., Shamon, L.A., Mata-Greenwood, E., Jang, J., Jeong, H.-J., Pisha, E., Mehta, R.G., and Kinghorn, A.D. Bioassay methods useful for activity-guided isolation of natural product cancer chemopreventive agents. In: K. Hostettmann, M.P. Gupta and A. Marston (eds.), Chemistry, Biological and Pharmacological Properties of Medicinal Plants from the Americas, Chur, Switzerland: Harwood Academic Publishers, pp. 81-110, 1998.

Kinghorn, A.D., Fong, H.H.S., Farnsworth, N.R., Mehta, R.G., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Cancer Chemopreventive Agents Discovered by Activity-Guided Fractionation: A Review. In: K. Hostettmann (ed.), Current Organic Chemistry, Hilversum, The Netherlands: Bentham Science Publishers, pp. 597-612, 1998.

Tan, G.T., Angerhofer, C.K., Mehdi, H., and Pezzuto, J.M. Novel Approaches to the Discovery and Characterization of Natural Product Drugs. In: I. Calis, T. Ersoz, and A.A. Basaran (eds.), New Trends and Methods in Natural Products' Research, Proceedings of XIIth International Symposium on Plant Originated Crude Drugs, Hacettepe University, Ankara, Turkey, pp. 225-250, 1998.

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Soejarto, D.D., Gyllenhaal, C., Regalado, J.C., Pezzuto, J.M., Fong, H.H.S., Tan, G.T., Hiep, N.T., Xuan, L.T., Binh, D.Q., Bich, T.Q., Thin, N.N., Loc, P.K., Vu, B.M., Southavong, B.H., Sydara, K., Bouamanivong, S., O'Neill, M.J., Lewis, J., Xie, X., and Dietzman, G. An International Collaborative Program to Study the Pharmaceutical Potential of Plants of Laos and Vietnam. Fifth Anticancer Drug Discovery and Development Symposium, Josephine Ford Cancer Center, Detroit, Michigan, September 23-25, 1999.

Öksüz, S., Cordell, G.A., and Pezzuto, J.M. Diterpenes of Turkish Euphorbia Species. 8th

International Symposium on Natural Product Chemistry, January 18-22, 2000, Karachi, Pakistan.

Kosmeder II, J.W. and Pezzuto, J.M. Intermediate Biomarkers, In: R.C. Bergan (ed.), Cancer Chemoprevention, Norwell, Massachusetts: Kluwer Academic Publishers, pp. 31-61, 2001.

Oksuz, S., Cordell, G.A., and Pezzuto, J.M. (2002) Diterpenes of Turkish Euphorbia species. In: A. Rahman, M.I. Choudhary, K.M. Khan (eds.), Natural Products Chemistry at the Turn of the Century, Karachi: Print Arts.

Park, E.J. and Pezzuto, J.M. "Autoxidation and Antioxidants," published in Encyclopedia of Pharmaceutical Technology, 2nd Edition, New York: Marcel Dekker, Inc., pp. 97-113, 2002.

Kang, Y.-H. and Pezzuto, J.M. Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens. In: H. Sies and L. Packer (eds.), Quinones and Quinone Enzymes (A Volume of Methods in Enzymology), San Diego, California: Elsevier Science (USA), 382: pp. 380-414. 2004.

Mehta, R.G. and Pezzuto, J.M. Phytochemicals as Potential Cancer Chemopreventive Agents. In: D. Bagchi, H.G. Preuss (eds.), Phytopharmaceuticals in Cancer Chemoprevention, Vol. 2, Boca Raton, Florida: CRC Press, 2004.

Pezzuto, J.M., Kosmeder II, J.W., Park, E.J., Lee, S.K., Cuendet, M., Gills, J., Bhat, K., Grubjesic, S., Park, H.-S., Mata-Greenwood, E., Tan, Y.M., Yu, R., Lantvit, D.D., and Kinghorn, A.D. Characterization of natural product chemopreventive agents. In: G.J. Kelloff, E.T. Hawk, and C.C. Sigman (eds.), Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention. Totowa, New Jersey: Humana Press Inc., pp. 3-37, 2005.

Pezzuto, J.M. Resveratrol as a cancer chemopreventive agent. In: B.B. Aggarwal and S. Shishodia (eds.), Resveratrol in Health and Disease, New York, New York: Marcel Dekker, Inc, pp. 233-383, 2006.

Pezzuto, J.M., Kondratyuk, T.P., and Shalaev, E. Cancer chemoprevention by wine polyphenols and resveratrol. In: W. Baer-Dubowska, A. Bartoszek and D. Malejka-Giganti (eds.), Carcinogenic and Anticarcinogenic Food Components, Boca Raton, Florida: CRC Press, 239-282, 2006.

Cuendet, M. and Pezzuto, J.M. Antitumor alkaloids in clinical use or in clinical trials. In: E. Fattorusso, O. Taglialatela-Scafati (eds.), Modern Alkaloids-Structure, Isolation, Synthesis and Biology. Hoboken, New Jersey: Wiley-VCH., pp. 25-52, 2008.

Cuendet, M. and Pezzuto, J.M. Molecular targets of botanicals used for chemoprevention. In: D.I. Abrams, A. Weil (eds.), Integrative Oncology. New York, New York: Oxford University Press, pp. 41-56, 2009.

Pezzuto JM, Park EJ, and Park EJ. Autoxidation and antioxidants, Encyclopedia of 86

Pharmaceutical Science and Technology, 4th Edition (EPST4), edited by J. Swarbrick, 2011.

Park, E.-J. and Pezzuto JM. Flavonoids in cancer prevention. Anticancer Agents MedChem. 12: 836-851, 2012.

Marler, M. and Pezzuto, J.M. Nutritional phytochemicals and the management of chronic inflammation. In: Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention. A.-N. T. Kong (ed.), Taylor & Francis, pp. 585-602, 2013.

Cuendet, M., Nievergelt, A. and Pezzuto, J.M. Molecular targets of botanicals used for chemoprevention. In: D.I. Abrams, A.T. Weil (eds.), Integrative Oncology (Second Edition), New York, New York: Oxford University Press, pp. 52-84, 2014.

Park, E.-J., Murphy, B.T., and Pezzuto, J.M. Marine organisms in cancer chemoprevention. In: B.J. Baker (ed.), Marine Biomedicine – from Beach to Bedside, CRC Press, pp. 279-339, 2016.

Book Reviews

Pezzuto, J.M. Review of In Vitro Methods in Toxicology, C.K. Atterwill and C.E. Steele, eds., pp. 458, 1987, for Int. J. Crude Drug Res. 26: 179-180, 1988.

Pezzuto, J.M. Review of Natural Products Chemistry III, Atta-ur-Rahman and P.W. LeQuesne, eds., pp. 374, 1988, for J. Med. Chem. 32: 2584-2585, 1989, and Int. J. Crude Drug Res. 28: 26, 1990.

Pezzuto, J.M. Review of Lewis, D.A., Anti-Inflammatory Drugs from Plant and Marine Sources. Agents and Actions Supplements, Vol. 27 (K. Brune, Series ed.), pp. 373, 1989, for Int. J. Crude Drug Res. 29: 158, 1991.

Pezzuto, J.M. Review of Living Resources for Biotechnology. Animal Cells, A. Doyle, R. Hay, and B.E. Kirsop, eds., pp. 191, 1991, for SIM Industrial Microbiology News 42: 174, 1992.

Pezzuto, J.M. Review of Adverse Effects of Herbal Drugs. Volume 1. P.A.G.M. De Smet, K. Keller, R. Hänsel, and R.F. Chandler, eds., pp. 275, 1992, for Int. J. Pharmacog. 31: 168, 1993.

Pezzuto, J.M. Review of Adverse Effects of Herbal Drugs. Volume 2. P.A.G.M. De Smet, K. Keller, R. Hänsel, and R.F. Chandler, eds., pp. 318, 1992, for Int. J. Pharmacog., 33: 265-266, 1995.

Pezzuto, J.M. Review of Prospecting for Drugs in Ancient and Medieval European Texts: A Scientific Approach, B.K. Holland, ed., pp. 105, 1996, for Nature Med., 2: 1392, 1996.

Pezzuto, J.M. Review of Pharmacological Methods in Phytotherapy Research, Volume 1, Selection, Preparation and Pharmacological Evaluation of Plant Material, by E. M. Williamson, D. T. Okpako, and F. J. Evans, pp. 228, 1996, for J. Nat. Prod., 60: 61-62, 1997.

Pezzuto, J.M. Review of Tamoxifen: Beyond the Antiestrogen, J.K. Kellen, ed., pp. 377, 1996; Tamoxifen: Over 6000 Scientific Papers and Still a Hot Topic, Trends in Endocrinology and Metabolism, 8: 288, 1997.

Pezzuto, J.M. Review of Wine: Nutritional and Therapeutic Benefits, T.R. Watkins, ed., pp. 284, 1997, for J. Nat. Prod., 61: 309, 1998.

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Pezzuto, J.M. Review of Natural Compounds in Cancer Therapy, J. Boik, ed., pp. 521, 2001, for Pharm. Biol., 40: 79, 2002.

Miscellaneous Editorial Contributions

Letter from the Editor. Int. J. Pharmacog., 31: 1-2, 1993.

Dedication, Cover Legend and Preface in: Proceedings of the Third Drug Discovery and Development Symposium, F.A. Valeriote and J.M. Pezzuto, pp. 122, Lisse: Swets & Zeitlinger, 1995.

Foreword in: Studies in Medicinal Chemistry. Vol. 1. Progress in Medicinal Chemistry, M. I. Choudhary (ed.) (Atta-ur-Rahman, Series ed.), Harwood Academic Publishers, 1996.

Contributed cover photograph for Nature Medicine, Vol. 1, Number 10, October 1995.

Contributed "Analysis of research" commentary "Taxol Production in Plant Cell Culture Comes of Age," Nature Biotechnology, 14: 1083, 1996.

Commentary entitled "Plant-derived Anticancer Agents," Biochem. Pharmacol., 53: 121-133, 1997. As of May 2006, this review is among the top 1% in terms of citations among all articles published in the journal over the past decade.

Contributed cover photograph for Biochem. Pharmacol., 53 (2), January 24, 1997.

Letter from the Editor. Pharm. Biol., 36: 2, 1998.

Foreword to Exploring the Power of Phytochemicals: Research Advances on Grape Compounds. Pharm. Biol., 36: 5, 1998.

Feature article entitled "Natural Inhibitors of Carcinogenesis," contributed to ISCaC Newsletter (International Society of Cancer Chemoprevention), Vol. 1, No. 2, pp. 2-5, 10-11, 1998.

Featured in "Meet the Editorial Board," Comb. Chem. High Throughput Screen. 2: 177-179, 1999.

Contributed to article entitled “Developing New Drugs” published in NCRR (National Center for Research Resources) Highlights 1996-1997, NIH Publication No.98-2309, pp. 24-29, printed March 1999.

Article entitled "The Search for New Cancer Treatments from Plant Sources," published in Pharmaceutical News, Vol. 6, No. 4 (Special Issue: Focus on Complementary Medicine), pp. 28-33, 1999.

Foreword in: Monographs, Vol. 1. Selected Indonesian Medicinal Plants, U. A. Jenie (ed.), 2003.

Contributed a felicitation letter published in the book entitled “Prof. Atta-ur-Rahman, Personality & Achievements” in honor of Prof. Atta-ur-Rahman’s 60th birthday, M. Iqbal Choudhary (ed.), 2003.

Foreword in: Medicinal Herbs: A Compendium, Varro E. Tyler (ed.), 2003/2004.88

Foreword in: Pharmaceutical Biology, Yali Hallock and Gordon Cragg (guest eds.), 2004, in press.

Commentary entitled "Resveratrol: A Whiff that Induces a Biologically Specific Tsunami," Cancer Biol. Ther., 3, 2004.

Suh, N. and Pezzuto, J.M. Strawberry Fields Forever? Cancer Prev Res; 5; 30–33, 2012 (Perspective).

Suh, N. and Pezzuto, J.M. Preface. Topics in Current Chemistry. Vol. 329. Natural Products in Cancer Prevention and Therapy. J.M Pezzuto and N. Suh (Eds.), pp. v-vii, Springer, New York / Heidelberg, 2013.

Vang, O. and Pezzuto, J,M. Introduction to Resveratrol and Health: 3rd International Conference. Ann. N. Y. Acad. Sci. 1348: v-vi doi, 2015.

Pezzuto, J.M. Preface for Grapes and Health. J.M. Pezzuto (Ed.), pp. 235, Springer-Verlag GmbH, Heidelberger, 2016.

Contributed cover feature for: Mol. Nutr. Food Res. 60: 1482-1500, 2016.

Books/Proceedings Edited

Progress on Terrestrial and Marine Natural Products of Medicinal and Biological Interest. Proceedings of a Symposium Held on the Occasion of the 60th Birthday of Professor Norman R. Farnsworth. J.M. Pezzuto, A.D. Kinghorn, H.H.S. Fong, and G.A. Cordell, eds., pp. 181, Austin: American Botanical Council, 1991.

Biotechnology and Pharmacy, J.M. Pezzuto, M.E. Johnson, and H.R. Manasse, Jr., eds., pp. 458, New York: Chapman and Hall, 1993.

Proceedings of the Third Drug Discovery and Development Symposium, F.A. Valeriote and J.M. Pezzuto, pp. 122, Lisse: Swets & Zeitlinger, 1995 (published as a supplement to Vol. 33 of the Int. J. Pharmacog.).

Proceedings of a Conference Exploring the Power of Phytochemicals: Research Advances on Grape Compounds, J.M. Pezzuto and V.E. Steele, pp. 80, Lisse, The Netherlands: Swets & Zeitlinger, 1998 (published as a supplement to Vol. 36 of Pharm. Biol.).

Phytochemistry and Pharmacognosy, edited by M.J. Kato and J.M. Pezzuto, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net] (2011).

Topics in Current Chemistry. Vol. 329. Natural Products in Cancer Prevention and Therapy. J.M Pezzuto and N. Suh (Eds.), pp. 257, Springer, New York / Heidelberg, 2013.

Grapes and Health. J.M. Pezzuto (Ed.), pp. 235, Springer-Verlag GmbH, Heidelberger, 2016.

Published Abstracts and Papers Presented

Pezzuto, J.M., Lea, M.A., and Yang, C.S. Binding of [3H]Benzo(a)pyrene Metabolites to 89

Nuclear Constituents of Rat Lung and Liver. Proc. Am. Assoc. Cancer Res. 17: 97, 1976.

Pezzuto, J.M., Lea, M.A., and Yang, C.S. Role of Microsomes and Nuclear Envelope in Benzo(a)pyrene Activation and Binding. Proc. Am. Assoc. Cancer Res. 18: 214, 1977.

Pezzuto, J.M., Honig, G.R., Antosiak, S.K., and Farnsworth, N.R. The Mechanism of Action of Fagaronine, a Novel Tumor Inhibitor. Proc. Am. Assoc. Cancer Res. 23: 206, 1982.

Medon, P.J., Pezzuto, J.M., Hovanec-Brown, J.M., Nanayakkara, N.P.D., Soejarto, D.D., Kamath, S.K., and Kinghorn, A.D. Safety Assessment of Some Stevia rebaudiana Sweet Principles. Fed. Proc. 41: 1568, 1982.

Hovanec-Brown, J.M., Makapugay, H.C., Nanayakkara, N.P.D., Soejarto, D.D., Pezzuto, J.M., Medon, P.J., Kamath, S.K., and Kinghorn, A.D. Sweet ent-Kaurene Glycosides from Stevia Herbarium Leaf Samples and Their Biological Evaluation. American Society of Pharmacognosy, Pittsburgh, August, 1982.

McPherson, D.D., Cordell, G.A., Soejarto, D.D., Pezzuto, J.M., and Fong H.H.S. Constituents of Caesalpinia pulcherrima. Novel Peltogynoids and Homoisoflavanoids. American Society of Pharmacognosy, Pittsburgh, August, 1982.

Farnsworth, N.R. and Pezzuto, J.M. Practical Pharmacologic Evaluation of Plants. University of Panama and International Foundation for Science, University of Panama, November, 1982.

Arisawa, M., Morita, N., Pezzuto, J.M., Kinghorn, A.D., Cordell, G.A., and Farnsworth, N.R. Anticancer Constituents of Ipomopsis aggregata (Polemoniaceae). Pharm. Soc., Japan, Tokyo, April, 1983.

Pezzuto, J.M., Nanayakkara, N.P.D., and Kinghorn, A.D. Steviol, the Aglycone of the Commercial Sweetening Agent Stevioside, is Mutagenic. Proc. Am. Assoc. Cancer Res. 24: 88, 1983.

Fang, X., Pezzuto, J.M., Fong, H.H.S., Phoebe, Jr., C.H., Farnsworth, N.R., Yellin, B., and Hecht, S.M. Isolation, Structure Elucidation, and Evaluation of the Cytotoxic Potential of Cucurbitacins from Elaeocarpus dolicostylus. American Society of Pharmacognosy, Oxford, MS, July, 1983.

Compadre, C.M., Nanayakkara, N.P.D., Pezzuto, J.M., and Kinghorn, A.D. Mass Spectral Analysis of the Mutagenic Diterpene Steviol, the Aglycone of the Commercial Sweetening Agent Stevioside, and Some of its Derivatives. American Society of Pharmacognosy, Oxford, MS, July, 1983.

Nanayakkara, N.P.D., Fang, X., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Demethyldeoxypodophyllotoxin, a Cytotoxic Constituent of Amanoa. American Society of Pharmacognosy, Austin, TX, Aug. 1984.

Wong, S.M., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Isolation, Structure Elucidation and Chemical Synthesis of Irisoquin, a Cytotoxic Constituent of Iris missouriensis. American Society of Pharmacognosy, Austin, TX, Aug. 1984.

Compadre, C.M., Pezzuto, J.M., Katz, N.L., Kamath, S.K., and Kinghorn, A.D. Hernandulcin, a New Kind of Naturally Occurring Intensively Sweet Compound: Safety and Sensory Studies. American Society of Pharmacognosy, Austin, TX, Aug. 1984

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Duh, C.Y., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic Constituents of Wikstroemia elliptica. American Society of Pharmacognosy, Austin, TX, Aug. 1984.

Wong, S.M., Pezzuto, J.M., Oshima, Y., Fong, H.H.S., and Farnsworth, N.R. Cytotoxic Triterpenes from Iris missouriensis. American Society of Pharmacognosy, Austin, TX, Aug. 1984.

Pezzuto, J.M., Nanayakkara, N.P.D., Compadre, C.M., Swanson, S.M., Kinghorn, A.D., Guenthner, T.M., Lam, L.K.T., Sparnins, V.L., and Wattenberg, L.W. Evaluation of the Potential of Steviol (13-Hydroxy-ent-kaurenoic Acid) and Related Diterpenes to Mediate Bacterial Mutagenesis and Induce Glutathione S-Transferase in Mice. Proc. Am. Assoc. Cancer Res. 26: 94, 1985.

Marshall, G.T., Lin, L.-J., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Activity of Some Diterpene Esters of the Tigliane, Daphnane, Ingenane, and Lathyrane Types. International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Fiebig, M., Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic Cardiac Glycosides of Streblus aster (Moraceae). International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Wong, S.M., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. A New Triterpene from Iris missouriensis Nutt. International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Compadre, C.M., Pezzuto, J.M., Nanayakkara, N.P.D., and Kinghorn, A.D. Identification and Mutagenic Assessment of Steviol Metabolites. International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Pezzuto, J.M., Braun, R.J., Nanayakkara, N.P.D., Compadre, C.M., and Kinghorn, A.D. Further Studies on the Mutagenic Mechanism of Action of ent-13-Hydroxykaur-16-en-19-oic Acid (Steviol). International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Swanson, S.M., Che, C.T., Cordell, G.A., Fong, H.H.S., and Pezzuto, J.M. Mutagenicity, Cytotoxicity, and Inhibition of DNA, RNA and Protein Biosynthesis by Aristolochic Acid and Several of Its Derivatives. International Research Congress on Natural Products, Univ. North Carolina at Chapel Hill, July 7-12, 1985.

Kinghorn, A.D., Compadre, C.M., and Pezzuto, J.M. Hernandulcin: An Intensely Sweet Compound from Lippia dulcis. Eighteenth Annual Meeting of the Calorie Control Council, Miami, FL, Oct. 20-22, 1985.

Kinghorn, A.D., Compadre, C.M., and Pezzuto, J.M. Further Studies on Stevioside. Eighteenth Annual Meeting of the Calorie Control Council, Miami, FL, Oct. 20-22, 1985.

Pezzuto, J.M. Assessment of the Mutagenic Potential of Stevioside. Fall meeting of the Midwest Regional Chapter of the Society of Toxicology, Northeastern Illinois Univ., Chicago, IL, Nov. 15, 1985.

Pezzuto, J.M. Chemistry, Metabolism and Biological Activity of Steviol, the Aglycone of Stevioside. Univ. Medicine and Dentistry of New Jersey, Newark, NJ, Dec. 18, 1985.

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Pezzuto, J.M. Metabolism and Biological Activity of ent-13-Hydroxykaur-16-en-19-oic Acid (Steviol), the Aglycone of Stevioside. Second International Symposium and Pakistan-U.S. Binational Workshop on Natural Products Chemistry, Karachi, Pakistan, Jan. 18-25, 1986.

Pezzuto, J.M. Overview of Research Programs Conducted in the Bioassay Research Facility of the College of Pharmacy, Univ. Illinois at Chicago. Shanghai College of Traditional Chinese Medicine, Shanghai, PRC, Feb. 1, 1986.

Pezzuto, J.M. Chemistry, Metabolism and Biological Activity of Steviol, the Aglycone of Stevioside. Otsuka Pharmaceutical Co. (Tokushima Research Inst.), Tokushima, Japan, Feb. 4, 1986. A similar lecture was presented at the Tokushima Bunri Univ., Tokushima, Japan, Feb. 5, 1986, and Hiroshima Univ., Hiroshima, Japan, Feb. 6, 1986.

Pezzuto, J.M. Evaluation of the Biological Activity of Steviol and Related ent-Kaurenes. Department of Pharmacology, University of Illinois, College of Medicine, Chicago, IL, March 7, 1986.

Pezzuto, J.M., Chou, J.S., Jiang, J.-X., Kudo, S., and Swanson, S.M. Effect of Retinyl Acetate on Benzo(a)pyrene Metabolism and Binding with Cultured Bronchus. Proc. Am. Assoc. Cancer Res. 27: 126, 1986.

Braun, R.J., Pezzuto, J.M., Ratko, T.A., and Beattie, C.W. Estrous Cycle Influence on the Repair of N-Methyl-N-Nitrosourea-Induced DNA Alkylation in Rat Mammary Epithelial Cells. Proc. Am. Assoc. Cancer Res. 27: 88, 1986.

Compadre, C.M., Hussain, R.A., Lopez de Compadre, R.L., Pezzuto, J.M., and Kinghorn, A.D. Structure-Activity Relationships for the Intensely Sweet Sesquiterpene Hernandulcin. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Wong, S.-M., Konno, C., Oshima, Y., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Irisones A & B: Two New Isoflavones from Iris missouriensis Nutt. (Iridaceae). American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Klocke, J.A., Nanayakkara, N.P.D., Compadre, C.M., Hussain, R.A., Pezzuto, J.M., and Kinghorn, A.D. Feeding Deterrent Effects on the Aphid, Schizaphis graminum, by Derivatives of the Sweet Compound, Stevioside. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Choi, Y.-H., Kim, J., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., Lotter, H., and Wagner, H. Agrostistachin, a Novel Casbane-type Diterpene from Agrostistachys hookeri, with Cytotoxic Activity. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D. and Farnsworth, N.R. Further Cytotoxic Constituents of Agrostistachys hookeri. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic Triterpene Esters from Stizophyllum riparium. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Isolation, Characterization, and Mechanistic Evaluation of Stizophyllin, a New Cytotoxic Pregnane Derivative from Stizophyllum riparium. American Society of Pharmacognosy, Ann Arbor, MI, July 1986.

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Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic Constituents of Agrostistachys hookeri. Sigma Xi Graduate Student Research Forum, University of Illinois at Chicago, April 9, 1986.

McPherson, D.D. and Pezzuto, J.M. A New Method of Detecting and Isolating Potential Anticancer Agents. Student Medical Research Forum, University of Illinois at Chicago, Jan. 31, 1986; Midwest Student Medical Research Forum, Ann Arbor, MI, Feb. 16-18, 1986; National Student Medical Research Forum, Galveston, TX, April 23-25, 1986.

Swanson, S.M., Jiang, J.-X., and Pezzuto, J.M. Evaluation of the Potential of Retinoids to Elevate Intracellular cAMP Concentration Employing Cultured Rat Glioma Cells. Federation Proc. 46: 1940, 1987.

Braun, R.J., Pezzuto, J.M., and Beattie, C.W. Estrous Cycle Status at the Time of N-Methyl-N-Nitrosourea (NMU) Exposure Influences Rat Mammary Tumor Growth and Ovariectomy-Induced Tumor Regression. Proc. Am. Assoc. Cancer Res. 28: 90, 1987.

Garg, P.K., Pezzuto, J.M., Swanson, S.M., and Lam, L.K.T. Cytotoxicity of Catechols and Quinones Structurally-Related to Butylated Hydroxyanisole. Proc. Am. Assoc. Cancer. Res. 28: 309, 1987.

Pezzuto, J.M., Swanson, S.M., Kirkish, M.A., Kudo, S., and Jones, R.T. Modulation of the Metabolism and Binding of Benzo(a)pyrene and (-)trans-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene by Retinyl Acetate Utilizing Bronchial Epithelial Cell and Explant Cultures as Model Systems. Proc. Am. Assoc. Cancer Res. 28: 145, 1987 (minisymposium).

Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D. and Farnsworth, N.R. Further Activity-Guided Isolation Studies on Agrostistachys hookeri. American Society of Pharmacognosy, Kingston, RI, July 1987.

Nanayakkara, N.P.D., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Intensely Sweet Dihydroflavonol Derivatives. American Society of Pharmacognosy, Kingston, RI, July 1987.

Swanson, S.M., Chang, Y.S., de Souza, N.J., and Pezzuto, J.M. Evaluation of Substances Capable of Elevating Intracellular cAMP Concentration Utilizing Cultured ASK Cells. American Society of Pharmacognosy, Kingston, RI, July 1987.

Pezzuto, J.M., Che, C.-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A. Development of a HPLC Method for the Detection of Potential Antitumor Agents that Interact with DNA. American Society of Pharmacognosy, Kingston, RI, July 1987.

Pezzuto, J.M. Short-term in Vitro Assays Useful for the Discovery of Drugs from Natural Sources. Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, Nov. 3, 1987.

Pezzuto, J.M. Retinoid Effect on Benzo(a)pyrene-Treated Human Bronchi. Department of Chemistry, Illinois Institute of Technology, Chicago, IL, Jan. 27, 1988.

Pezzuto, J.M. Tumor Cell Biology Lecture Series. Carcinogenesis Due to Exogenous Agents, Rush Cancer Center, Rush Medical College, Chicago, IL. Lectures presented: An Overview of Chemical Carcinogenesis (Jan. 21, 1988); The Interaction of Chemical Carcinogens with DNA and Other Cellular Macromolecules (Jan. 28, 1988); Chemical Carcinogenesis as a

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Multistep Process (Feb. 4, 1988); Inhibition of Chemical Carcinogenesis (Feb. 11, 1988).

Kim, J., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Sweet Steroidal Glycosides from the Rhizomes of Polypodium glycyrrhiza. International Congress on Natural Products Research, Park City, Utah, July 1988.

Hussain, R.A., Poveda, L.M., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Phenylpropanoid Constituents of Some Sweet Plants. International Congress on Natural Products Research, Park City, Utah, July 1988.

Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Constituents of the Bark of Plumeria rubra Grown in Indonesia. International Congress on Natural Products Research, Park City, Utah, July 1988.

Pezzuto, J.M., Che, C.-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A. Biospecific Identification and Isolation of Naturally Occurring Potential Antitumor Agents. NIH Workshop: Bioassays for Discovery of Antitumor and Antiviral Agents from Natural Sources, Lister Hill Auditorium, National Library of Medicine, Bethesda, MD, Oct. 18-19, 1988.

Pezzuto, J.M. Steviol-Mediated Mutagenicity. National Cancer Institute-Frederick Cancer Research Facility, Frederick, MD, October 20, 1988.

Pezzuto, J.M. Alternative Methodology. Biological Resources Laboratory, University of Illinois at Chicago, Chicago, IL, November 15, 1988.

Pezzuto, J.M. Natural Inhibitors of Carcinogenesis. XVI International Symposium on Natural Products, University of Monterrey, Monterrey, Mexico, April 27-29, 1989.

Pezzuto, J.M. Bioassay Procedures Applicable for the Discovery of Natural Product Drugs. Instituto Mexicano del Seguro Social, Xochitepec, Mexico, May 2, 1989.

Pezzuto, J.M. An Overview of Carcinogenesis and Genetic Toxicity. Biological Resources Laboratory, University of Illinois at Chicago, Chicago, IL, May 16, 1989.

Tan, G.T., Pezzuto, J.M., and Kinghorn, A.D. Screening of Natural Products for the Inhibition of Human Immunodeficiency Virus Reverse Transcriptase (HIV RT): A Potential Target in the Treatment of AIDS. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Novel Iridoids from the Bark of Plumeria rubra of Indonesian Origin. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Hussain, R.A., Fullas, F., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Articulin 2-acetate, A Cytotoxic Diterpene Constituent of Baccharis gaudichaudiana. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Choi, Y.-H., Hussain, R.A., Pezzuto, J.M., and Kinghorn, A.D. Four Highly Sweet Triterpene Glycosides from the Leaves of Abrus precatorius. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Kigodi, P.G.K., Blaskó, G., Thebtaranonth, Y., Pezzuto, J.M., and Cordell, G.A. Isolation and Spectroscopic Investigation of Nimbolide and 28-Deoxonimbolide from Azadiracta indica. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

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Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Mechanism of Action of Acronycine and Its Derivatives. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Mar, W. and Pezzuto, J.M. Biologically Active Alkaloids from Albizia amara Isolated on the Basis of Interaction with DNA. International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Pezzuto, J.M., Che, C.-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A. DNA as an Affinity Probe Useful in the Isolation of Biologically Active Natural Products (Workshop on "Simple Bioassays"). International Research Congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989.

Dai, J., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Studies on the Constituents of Baccharis articulata, a Plant used in Paraguayan Folk Medicine. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Fullas, F., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Differential Taste Characteristics of Three Novel Labdane-Type Glycoside Analogs from Baccharis gaudichaudiana. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Isoflavonoids of the Seeds of Pachyrrhizus erosus. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Swanson, S.M. and Pezzuto, J.M. Retinol and Several of Its Derivatives are Inhibitors of Calmodulin-Stimulated 3',5'-Cyclic Nucleotide Phosphodiesterase. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Mar, W., Hendon, J.L., Kadic, J.T., and Pezzuto, J.M. Evaluation of Plant Materials and Other Pure Natural Products as Potential Inhibitors of Tumor Promotion. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Nshima, C.M., Pezzuto, J.M., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Phytochemical and Cytotoxicity Studies on Muntingia calabura Collected in Thailand. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Pezzuto, J.M., Beattie, C.W., Lowell, K., Mar, W., Swanson, S.M., Reutrakul, V., Kinghorn, A.D., and Farnsworth, N.R. Evaluation of the Cytotoxic Potential of Natural Products Employing a Battery of Human Cancer Cell Lines. Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990.

Swanson, S.M. and Pezzuto, J.M. Retinol and Several of Its Derivatives are Inhibitors of Calmodulin-Stimulated 3',5'-Cyclic Nucleotide Phosphodiesterase. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 3-5, 1990.

Mar, W., Hendon, J.L., Kadic, J.T., and Pezzuto, J.M. Evaluation of Plant Materials and Other Pure Natural Products as Potential Inhibitors of Tumor Promotion. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 3-5, 1990.

Fullas, F., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Differential

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Taste Characteristics of Three Novel Labdane-Type Glycoside Analogs from Baccharis gaudichaudiana. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 3-5, 1990.

Kardono, L.B., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Pachyrrhisomene, A Novel Coumaronachromene Isolated from the Seeds of Pachyrrhizus erosus. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 3-5, 1990.

Cordell, G.A., Pezzuto, J.M., and Beecher, C.W.W. Can Ethnopharmacology Contribute to the Development of New Anticancer Agents? First International Congress on Ethnopharmacology, Strasbourg, France, June 5-9, 1990.

Tan, G.T., Pezzuto, J.M., and Kinghorn, A.D. Evaluation of Natural Products as Inhibitors of Human Immunodeficiency Virus (HIV) Reverse Transcriptase. International Symposium, Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, July 17-22, 1990.

Pezzuto, J.M., Beattie, C.W., Lowell, K., Mar, W., Swanson, S.M., Reutrakul, V., Kinghorn, A.D., and Farnsworth, N.R. Evaluation of the Cytotoxic Potential of Natural Products Employing a Battery of Human Cancer Cell Lines. International Symposium, Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, July 17-22, 1990.

Kaneda, N., Pezzuto, J.M., Soejarto, D.D., Kinghorn, A.D., Farnsworth, N.R., Tucindra, P., Udchachol, J., Santisuk, T., and Reutrakul, V. New Cytotoxic Flavonoids from Muntingia calabura roots. International Symposium, Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, July 17-22, 1990.

Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Constituents of the Seeds of Pachyrrhizus erosus. International Symposium, Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, July 17-22, 1990.

Hussain, R.A., Fullas, F., Bordas, E., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Structure-Sweetness Relationships of Some Labdane-Type Diterpenes from Baccharis gaudichaudiana. International Symposium, Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, July 17-22, 1990.

Rotella, D.P., He. Q., Pezzuto, J.M., and Tipton, C.L. Structure-Activity and Cytotoxicity Studies of Irreversible Calmodulin Antagonists Based on a Natural Product Model. American Chemical Society, Medicinal Chemistry Symposium, Univ. Texas, Austin, July 29-Aug. 2, 1990.

Pezzuto, J.M. Bioassay-Directed Discovery of Natural Product Drugs. Department of Pharmacy, Eidgenoessische Technische Hochschule (ETH) Zurich, Zurich, Switzerland, July 2, 1990.

Pezzuto, J.M. Short-term Bioassays and Natural Product Drug Discovery, Institute for Pharmacognosy, University of Innsbruck, Innsbruck, Austria, Nov. 8, 1990.

Wagner, H., Pezzuto, J.M., Melchart, D., Linde, K., and Kreher, B. Effects of Ultra-Low Doses in Immunology (A Survey). 4th Symposium, International Research Group on Very High Dilution Effects, Paris, France, November 30-December 1, 1990.

Mar, W., Cordell, G.A., Lin, L.-Z., Che, C.-T., Tan, G.T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., Neszmélyi, A., Jurcic, K., Offermann, F., Redl, K., Steinke, B., Wagner, H. and

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Pezzuto. J.M. DNA-Based Isolation of Natural Products. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, April 25-27, 1991.

Lardono, L.B.S., Angerhofer, C.K., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic and Antimalarial Alkaloids from the Roots of Eurycoma longifolia. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, April 25-27, 1991.

Fullas, F., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Bioactive Labdane and Clerodone Diterpenoids from Baccharis gaudichaudiana. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, April 25-27, 1991.

Dai, J., Kardono, L.B.S., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Phenylacetic Acid Derivatives from the Medicinal Plant Entada phaseoloides. Twenty-eighth Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, April 25-27, 1991.

Kaneda, N., Chai, H., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., Tuchinda, P., Udchachon, J., Santisuk, T., and Reutrakul, V. Cytotoxic Activity of Cardenolides from Beaumontia brevituba Oliver (Apocynaceae). International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Tan, G.T., Kinghorn, A.D., Hughes, S.H., and Pezzuto, J.M. Psychotrine and its Methyl Ester are Selective Inhibitors of Human Immunodeficiency Virus-1 Reverse Transcriptase. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Pezzuto, J.M., Mar, W., Lin, L.-Z., Cordell, G.A., Neszmélyi, A., and Wagner, H. Structure Elucidation of New Macrocyclic Alkaloids from Albizia amara. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

König, G.M., Wright, A.D., Sticher, O., Jurcic, K., Offermann, F., Redl, K., Wagner, H., Angerhofer, C.K., and Pezzuto, J.M. Evaluation of the Cytotoxic, Antimalarial and Antiinflammatory Activities of Compounds Isolated from Marine Organisms. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Mar, W., Cordell, G.A., Lin, L.-Z., Che, C.-T., Tan, G.T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., Neszmélyi, A., Jurcic, K., Offermann, F., Redl, K., Steinke, B., Wagner, H., and Pezzuto, J.M. DNA-Based Isolation of Natural Products. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Gerhäuser, C., Samtleben, R., Tan, G.T., Pezzuto, J.M., and Wagner, H. Inhibition of HIV-1 Reverse Transcriptase and of in vitro Protein Synthesis by a Protein Fraction of the Seeds of Cucurbita pepo (Cucurbitaceae). International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Fullas, F., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. New Cytotoxic Labdane and Clerodane Diterpene Constituents from Baccharis gaudichaudiana. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Likhitwitayawuid, K., Cordell, G.A., Ruangrungsi, N., Angerhofer, C.K., and Pezzuto, J.M. Cytotoxic and Antimalarial Bisbenzylisoquinolines from Stephania erecta. International Research

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Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Saifah, E., Likhitwitayawuid, K., Cordell, G.A., and Pezzuto, G.A. Studies on the Cytotoxicity of Bisamides from Aglaia species. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Evaluation of the Effects of the Broad-Spectrum Antitumor Alkaloid Acronycine and Selected Semisynthetic Derivatives on in Vitro DNA and RNA Synthesis. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Kardono, L.B.S., Angerhofer, C.K., Tsaui, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic and Antimalarial Alkaloids from the Roots of Eurycoma longifolia. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Dai, J.-R., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Novel Clerodane and Labdane Diterpenoids from Baccharis articulata. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

Dai, J.-R., Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Phenylacetic Acid Derivatives from the Medicinal Plant Entada Phaseoloides. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26, 1991.

König, G.M., Wright, A.D., Sticher, O., Jurcic, K., Offermann, F., Redl, K., Wagner, H., Angerhofer, C.K., and Pezzuto, J.M. Structure Elucidation and Biological Activity of Secondary Metabolites from Marine Red and Brown Algae. GA Conference, Saarbrücken, September 1991.

Novak, R.M., Keyer, K.A., Kinghorn, A.D., and Pezzuto, J.M. Antiviral Activity of the Plant Compound Fagaronine Chloride, a Reverse Transcriptase Inhibitor in HIV-Infected Peripheral Blood Mononuclear Cells and T Cell Lines. VII International Conference on AIDS, Florence, Italy, June 16-21, 1991.

Cordell, G.A., Pezzuto, J.M., Lin, L.-Z., Lin, L.-J., Shieh, H.-L., Mar, W., Kikhitwitayawiud, K., Angerhofer, C.K., Lankin, D.C., Xue, L., Johnson, M.E., Balandrin, M.E., Ulubelen, A., Topçu, G., Ruangrungsi, N., Saifay, E., Neszmélyi, A., and Wagner, H. Anticancer and Antimalarial Agents from Plants. ASOMPS VII Meeting, Manila, February 1992.

Tan, G.T., Hughes, S.H., Pezzuto, J.M., Singh, R., Wickramasinghe, A., Verma, S., and Mohan, P. Sulfonic Acid Derivatives are Highly Potent Inhibitors of HIV-2 Reverse Transcriptase. American Association for the Advancement of Science Annual Meeting, Chicago, February 6-11, 1992.

Pezzuto, J.M. Naturally Occurring Cancer Chemopreventive Agents. American Chemical Society Symposium entitled "Human Medicinal Agents from Plants," 203th Annual Meeting of the ACS, San Francisco, CA, April 5-10, 1992.

Mohan, P., Verma, S., Tan, G.T., Wickramasinghe, A., Singh, R., Hughes, S.H., and Pezzuto, J.M. Synthesis of Naphthalenesulfonic Acid and Inhibition of HIV-1 and HIV-2 Reverse Transcriptase Activity. American Chemical Society, 25th Great Lakes Regional Meeting,

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Milwaukee, WI, June 1-3, 1992.

Alkan, M.H., Shanmugam, S., Tavoc, D., Chai, H.B., and Pezzuto, J.M. Mixed Micelles as Proliposomes for Solubilization of Taxol: Cytotoxic Potential and Vehicle Toxicity. Second Liposome Research Days Meeting, Leiden, The Netherlands, June 17-19, 1992.

Lin, L.-Z., Xue, L., Shieh, H.-L., Angerhofer, C.K., Pezzuto, J.M., Johnson, M.E., and Cordell, G.A. Cytotoxic and Antimalarial Bisbenzylisoquinoline Alkaloids for Cyclea barbata. 33rd Annual Meeting of the American Society of Pharmacognosy, Williamsburg, VA, July 26-31, 1992.

Luyengi, L., Che, C.-T., Bowen, P.E., Waller, D.P., Beecher, C.W.W., Pezzuto, J.M., and Fong, H.H.S. Linusitamarin, a New Phenylpropanoid Glucoside from Linum usitatissimum L. (Linaceae). 33rd Annual Meeting of the American Society of Pharmacognosy, Williamsburg, VA, July 26-31, 1992.

Likhitwitayawuid, K., Angerhofer, C.K., Ruangrungsi, N., Cordell, G.A., and Pezzuto, J.M. Studies on the Cytotoxic and Antimalarial Activities of Isoquinoline Alkaloids from Stephania pierrii. 33rd Annual Meeting of the American Society of Pharmacognosy, Williamsburg, VA, July 26-31, 1992.

Ríos, Y.R., Bas, N.T.M., Antoun, M.D., Wickramaratne, D.B.M., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxicity of Hymenocallis expansa Alkaloids. 33rd Annual Meeting of the American Society of Pharmacognosy, Williamsburg, VA, July 26-31, 1992.

Pereda-Miranda, R., Mata, R., Anaya, A.L., Pezzuto, J.M., Wickramaratne, D.B.M., and Kinghorn, A.D. Structure and Biological Activities of Tricolorin A, Major Phytogrowth-Inhibitor from Ipomoea tricolor. 33rd Annual Meeting of the American Society of Pharmacognosy, Williamsburg, VA, July 26-31, 1992.

Pereda-Miranda, R., Hernandex, L., Villavicencio, M.J., Novelo, M., and Pezzuto, J.M. Pectinolides A-C, Novel Antimicrobial and Cytotoxic 5,6-Dihydro--pyrones from Hyptis Pectinata (Lamiaceae). Phytochemical Society of North America, Miami Beach, Florida, August 8-12, 1992.

König, G.M., Wright, A.D., Sticher, O., Angerhofer, C.K., and Pezzuto, J.M. Bioactive Marine Natural Products: Antimalarial Activity of Sponge Metabolites. 40th Annual Congress on Medicinal Plant Research, Trieste, Sept. 1-5, 1992.

Cordell, G.A., Farnsworth, N.R., Beecher, C.W.W., Kinghorn, A.D., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J., and Tait, R.M. Plant-Derived Anticancer Agents for Therapy. 4th International Congress on Phytotherapy, Munich, Germany, Sept. 10-13, 1992.

Pezzuto, J.M. Bioassay-Directed Discovery of Natural Product Drugs. XII Simpósio de Plantas Medicinais do Brasil, Curitiba, Paraná, Brazil, Sept. 15-17, 1992.

Verma, S., Tan, G.T., Wickramasinghe, A., Hughes, S.H., Pezzuto, J.M., Baba, M., and Mohan, P. Novel Sulfonic Acid Polymers are Highly Potent Inhibitors of HIV-1 and HIV-2 Reverse Transcriptase. XII Midwest Enzyme Chemistry Conference, University of Chicago, Chicago, Illinois, Oct. 10, 1992.

Ungwitayatorn, J., Teruna, H., Tan, G., Sheu, W., del Rosario-Chow, M., Krstenanshi, J.L., Pezzuto, J.M., Mohan, P., and Currie, B.L. XII Midwest Enzyme Chemistry Conference, University of Chicago, Chicago, Illinois, Oct. 10, 1992.

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Pezzuto, J.M. Natural Product Drug Discovery. Department of Pharmacology, University of West Virginia, Morgantown, West Virginia, Oct. 19, 1992 (elected by student body for annual presentation).

Mehta, R.G., Constantinou, A., Moriarty, R., Pezzuto, J.M., and Moon, R.C. Brassinin: A Novel Chemopreventive Agent. Proc. Am. Assoc. Cancer Res. 34: 127, 1993 (84th Annual Meeting of the American Association for Cancer Research, Orlando, FL, May 19-22, 1993).

Beecher, C.W.W., Farnsworth, N.R., Fong, H.H.S., Kinghorn, A.D., Mehta, R.G., Moon, R.C., Moriarty, R.M., Pezzuto, J.M., Soejarto, D.D., Wall, M.E., and Wani, M. Identification and Characterization of Natural Inhibitors of Carcinogenesis. Proc. Am. Assoc. Cancer Res. 34: 559, 1993 (84th Annual Meeting of the American Association for Cancer Research, Orlando, FL, May 19-22, 1993).

Beecher, C.W.W., Pezzuto, J.M., and Farnsworth, N.R. Meta-analysis of Published Literature as a Means of Chemopreventive Drug Discovery. Proc. Am. Assoc. Cancer Res. 34: 127, 1993 (84th Annual Meeting of the American Association for Cancer Research, Orlando, FL, May 19-22, 1993).

Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Bioassay-Directed Isolation of Natural Inhibitors of Carcinogenesis. Proc. Am. Assoc. Cancer Res. 34: 558, 1993 (84th Annual Meeting of the American Association for Cancer Research, Orlando, FL, May 19-22, 1993).

Mohan, P., Verma, S., Tan, G.T., Wickramasinghe, A., Pezzuto, J.M., Hughes, S.H., and Baba, M. Sulfonic Acid Polymers: Highly Potent Inhibition of HIV-1 and HIV-2 Reverse Transcriptase and Antiviral Activity. 205th National Meeting of the American Chemical Society, Denver, CO, March 28-April 2, 1993.

Pezzuto, J.M. Cancer Chemopreventive Agents: From Plant Materials to Clinical Intervention Trials. Functional Foods for Health (UIC/UIUC Joint Program), Second Annual Meeting, Monticello, IL, May 10-12, 1993.

Mar, W. and Pezzuto, J.M. Chemoprevention of Cancer: Model Systems for Studying the Inhibition of Tumor Promotion. Functional Foods for Health (UIC/UIUC Joint Program), Second Annual Meeting, Monticello, IL, May 10-12, 1993.

Pisha, E. and Pezzuto, J.M. Dietary Phytoestrogens and Human Disease. Functional Foods for Health (UIC/UIUC Joint Program), Second Annual Meeting, Monticello, IL, May 10-12, 1993.

Suh, N., Fong, H.H.S., Moriarty, R.M., and Pezzuto, J.M. Cell Differentiation Effects of Extracts from Medicinal/Dietary Plants and Vitamin D Derivatives. Functional Foods for Health (UIC/UIUC Joint Program), Second Annual Meeting, Monticello, IL, May 10-12, 1993.

Shamon, L.A., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. A Correlative Approach to the Discovery of Dietary Antimutagens that Demonstrate Cancer Chemoprevention Activity. Functional Foods for Health (UIC/UIUC Joint Program), Second Annual Meeting, Monticello, IL, May 10-12, 1993.

Alkan-Onyuksel, H., Son, K., Shanmugam, S., and Pezzuto, J.M. Mixed Micelles as Proliposomes for the Delivery of Insoluble Drugs by Intravenous Route. 3rd International Symposium of Pharmaceutical Sciences, Ankara, Turkey, June 15-18, 1993.

Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., and Beecher, C.W.W. New

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Strategies for the Discovery of Plant-Derived Anticancer Agents. 3rd International Symposium of Pharmaceutical Sciences, Ankara, Turkey, June 15-18, 1993.

Rimando, A.M., Pezzuto, J.M., Farnsworth, N.R., Santisuk, T., and Reutrakul, V. New Bioactive Lignans for Anogeissus acuminata. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Guinaudeau, H., Lin, L.-Z., Ruangrungsi, N., Pezzuto, J.M., and Cordell, G.A. Cytotoxic Bisbenzylisoquinoline Alkaloids from Pachygone dasycarpa (Menispermaceae). 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Lin, L.-Z., Hu, S.-F., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. New Aporphinoid Alkaloids for Thalictrum faberi. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Lin, L.-Z., Hu, S.-F., Angerhofer, C.K., Pezzuto, J.M., Cordell, G.A., and Ruangrungsi, N. Lycorine Alkaloids for Hymenocallis littoralis. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Gil, R., Pezzuto, J.M., Chai, H.-B., and Cordell, G.A. New Cardinolides from Nierembergia stricta (Solanaceae). 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D. Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J.A., Tait, R.M., Besterman, J.D., and Harris, T.J.R. Novel Strategies for Plant-Derived Anticancer Agents. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Wickramaratne, D.B.M., Pengsuparp, T., Mar, W., Chai, H.-B., Chagwedera, T.E., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., and Cordell, G.A. Novel Antimitotic Dibenzocyclo-octadiene Lignans from Steganotaenia araliacea. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Baek, N.-I., Chung, M.-S., Shamon, L., Kardono, L.B.S., Tsauri, S., Padmawinata, K., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Selligueain A, a Novel Highly Sweet Proanthocyanidin from the Rhizomes of Selliguea feei. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Luyengi, L., Lee, I.-S., Mar, W., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. New Constituents of Mundulea sericea with Ornithine Decarboxylase Inhibitory Activity. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

You, M., Shieh, H.-L., Cordell, G.A., and Pezzuto, J.M. Mechanism of Collateral Cytotoxicity Mediated by Acronycine Against Multi-Drug Resistant KB Carcinoma Cell Lines. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Mar, W., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., Moon, R.C., Mehta, R.G., and Pezzuto, J.M. Model Systems for the Detection of Chemopreventive Agents from Plant Leads. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Shamon, L.A., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. A Correlative Approach to the Discovery of Antimutagens that Demonstrate Cancer Chemopreventive Activity. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

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Suh, N., Fong, H.H.S., Moriarty, R.M., and Pezzuto, J.M. Cell Differentiation Effects and Cytotoxicity of Extracts for Medicinal Plants and Vitamin D Derivatives. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Pereda-Miranda, R., Novelo, M., Cruz, J.G., Hernandez, L., Chai, H., Mar, W., and Pezzuto, J.M. Cytotoxic Constituents from Hyptis verticillata. 34th Annual Meeting of the American Society of Pharmacognosy, San Diego, CA, July 18-22, 1993.

Shamon, L.A., Verma, S., Wong, M.F., Huang, P.P., Pezzuto, J.M., and Mohan, P. Potential Antineoplastic Agents: Sulfonic Acid Derivatives with Potent Inhibitory Activity Against Cultured Human Prostate Cancer Cells. 206th Annual Meeting of the American Chemical Society, Chicago, IL, Aug. 22-28, 1993.

Rimando, A.M., Pezzuto, J.M., Farnsworth, N.R., Santisuk, T., and Reutrakul, V. Structure and Biological Activity of New Compounds from Anogeissus acuminata. 206th Annual Meeting of the American Chemical Society, Chicago, IL, Aug. 22-28, 1993.

Angerhofer, C.K., Guinaudeau, H., Lin, L.-Z., Likhitwitayawuid, K., Wongpanich, V., Pezzuto, J.M., Ruangrungsi, N., and Cordell, G.A. Antimalarial and Cytotoxic Activity of Natural Bisbenzylisoquinoline Alkaloids. 42nd Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta, GA, Oct. 31-Nov. 4, 1993.

Soejarto, D.D., Kinghorn, A.D., and Pezzuto, J.M. The Search for New Drugs Useful for the Treatment of Cancer and AIDS. The Women's Board of the Field Museum of Natural History, Field Museum of Natural History, Chicago, IL, November 18, 1993.

Cordell, G.A., Angerhofer, C.K., and Pezzuto, J.M. Antitumor, Antimalarial and Anti-HIV Agents from Plants. 19th IUPAC Symposium on the Chemistry of Natural Products, Karachi, Pakistan, January 16-20, 1994.

Öksüz, S., Cordell, G.A., Pezzuto, J.M., Ulubelen, A., Gil, R.R., and Özhatay, N. Biologically Active Compounds from the Euphorbiaceae of Turkey. 19th IUPAC Symposium on the Chemistry of Natural Products, Karachi, Pakistan, January 16-20, 1994.

Mar, W., Suh, N., Cai, L., Kinghorn, A.D., Fong, H.H.S., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Pentacyclic Triterpene Chemopreventive Agents that Stimulate Protein Kinase C Activity. Proc. Am. Assoc. Cancer Res., 35: 627, 1994 (85th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 10-13, 1994).

Pezzuto, J.M., Mar, W., Luyengi, L., Kinghorn, A.D., Fong, H.H.S., Halline, A.G., Mehta, R.G., and Moon, R.C. Rotenoid-mediated Inhibition of Ornithine Decarboxylase Activity as a Mechanism of Chemopreventive Activity. Proc. Am. Assoc. Cancer Res., 35: 627, 1994 (85th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 10-13, 1994).

You, M., Gerhäuser, C., Liu, J., Moriarty, R.M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Induction of Quinone Reductase Activity Mediated by Brassinin and Its Derivatives. Proc. Am. Assoc. Cancer Res., 35: 627, 1994 (85th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 10-13, 1994).

Seo, E.-K., Chai, H.-B., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Flavanones from the Leaves of Monotes engleri. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

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Mbwanbo, Z.H., Mar, W., Pezzuto, J.M., and Kinghorn, A.D. A Novel Constituent of Euphorbia quinquiocostata with Ornithine Decarboxylase Inhibitory Activity. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

Suh, N., Gerhäuser, C., Cai, L., Kinghorn, A.D., Fong, H.H.S., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Pentacyclic Triterpene Chemopreventive Agents that Stimulate Protein Kinase C Activity but Antagonize Responses Mediated by 12-O-Tetradecanylphorbol-13-acetate (TPA). Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

You, M., Gerhäuser, C., Liu, J., Moriarty, R.M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Induction of Quinone Reductase Activity Mediated by Brassinin and Its Derivatives Correlates with Inhibition of 7,12-Dimethylbenz(a)anthracene (DMBA)-induced Lesion Formation in Mammary Organ Culture. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

Pengsuparp, T., Cai, L., Fong, H.H.S., Kinghorn, A.D., Pezzuto, J.M., and Cordell, G.A. Natural Products Derived from Plants Demonstrate Potent Inhibition of HIV-1 Reverse Transcriptase. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

Jang, M.-S., Cai, L., Kinghorn, A.D., Fong, H.H.S., Wagner, H., and Pezzuto, J.M. Bioassay-Directed Isolation of Potential Cancer Chemopreventive Agents Utilizing Inhibition of Cyclooxygenase Activity as a Monitor. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

Pisha, E., Waller, D.P., Che, C.-T., Beecher, C.W.W., Lu, L., Pezzuto, J.M., and Fong, H.H.S. Isolation and Identification of Phytoestrogens from Triticum aestivum and Erythrina rubrinervia. Thirty-second Annual Medicinal Chemistry Meeting-in-Miniature, Chicago, Illinois, May 20-22, 1994.

Pezzuto, J.M. Antitumor Drug Discovery as a Multidisciplinary Effort. Integration of Traditional Oriental Medicines and Modern Sciences, Seoul, Korea, June 3-4, 1994.

Shamon, L., Lee, I.-S., Kinghorn, A.D., and Pezzuto, J.M. Evaluation of the Cytotoxic Mechanism Mediated by the Diterpene Lactone 13-Methoxy-15-oxozopatlin. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Ma, X., Lee, I.-S., Chai, H.-B., Madulid, D.A., Lamont, R.B., Besterman, J.M., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic Labdane Diterpenoids from Neouvaria acuminatissima. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Ma, X., Lee, I.-S., Chai, H.-B., Zaw, K., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Clerodane Diterpenes from Polyalthia barnesii. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Lee, I.-S., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D. Rearranged ent-Kaurenoids with Cytotoxic Activity From Parinari curatellifolia. International Research Congress on Natural Products and 35th Annual Meeting of

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the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Gerhäuser, C., Mar, W., Lee, S.-K., Luyengi, L., Mbwanbo, Z., Cai, L., Kinghorn, A.D., Fong, H.H.S., and Pezzuto, J.M. Discovery of Plant-Derived Natural Products that Inhibit Phorbol Ester-Induced Ornithine Decarboxylase (ODC) Activity and Reduce ODC mRNA Expression in Cultured Mouse 308 Cells. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

You, M., Ma, X.-J., Mukherjee, R., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Bioassay-Directed Isolation of Indole Alkaloids for Peschiera laeta that Reverse Multidrug-Resistance. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Jang, M.-S., Cai, L., Kinghorn, A.D., Fong, H.H.S., Wagner, H., and Pezzuto, J.M. Bioassay-Directed Isolation of Potential Cancer Chemopreventive Agents Utilizing Inhibition of Cyclooxygenase Activity as a Monitor. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Pisha, E., Waller, D.P., Che, C.-T., Beecher, C.W.W., Lu, L., Pezzuto, J.M., and Fong, H.H.S. Isolation of Potential Anti-Estrogenic Compounds from Plants. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Suh, N., Mar, W., Cai, L., Luyengi, L., Kinghorn, A.D., and Pezzuto, J.M. Evaluation of Chemopreventive Agents that Stimulate Protein Kinase C Activity but Inhibit Tumorigenesis. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Sun, H.-D., Lin, Z.-W., Niu, F.D., Lin, L.-Z., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. Cytotoxic ent-Kaurene Diterpenoids from Three Isodon Species. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Sun, H.-D., Lin, Z.-W., Niu, F.-D., Lin, L.-Z., Angerhofer, C.K., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cytotoxic Diterpenoids from Isodon megathyrsus. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Mehta, R., You, M., Hawthorn, M., Thomas, C., Constantinou, A., Liu, J., Gerhäuser, C., Moriarty, R.M., Pezzuto, J.M., and Moon, R.C. Cancer Chemopreventive Activity of Phytoalexin Derived from Chinese Cabbage and Its Mechanism of Action. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Kennelly, E.J., Cai, L., Long, L., Shamon, L., Chung, M.-S., Zaw, K., Zhou, B.-N., Pezzuto, J.M., and Kinghorn, A.D. A Novel Highly Sweet Secodammarane Glycoside from Cyclocarya paliurus. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Wongpanich, V., Lin, L.-Z., You, M., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. Aporphine-Benzylisoquinoline Alkaloids for Thalictrum faberi with Antimalarial Activity.

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International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Luyengi, L., Suh, N., Luo, Y., Lee, S.-K., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Potential Cancer Chemopreventive Constituents from Dirca occidentalis. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Mbwambo, Z., Mar, W., Lee, S.-K., Mshiu, E.N., Pezzuto, J.M., and Kinghorn, A.D. A Novel Benzenoid from Euphorbia quinquecostata with Ornithine Decarboxylase Inhibitory Activity. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Angerhofer, C.K., Guinaudeau, H., Lin, L.-Z., Likhitwitayawuid, K., Wongpanich, V., Pezzuto, J.M., and Cordell, G.A. Antimalarial and Cytotoxic Activity of Natural Bisbenzylisoquinoline Alkaloids. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

MacKinnon, S.L., Arnason, J.T., Durst, T., Angerhofer, C.K., Pezzuto, J.M., and Uck, F. Structure/Activity Relationships of the Antimalarial and Antifeedant D-Seco Limonoid Gedunin. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Chaudhuri, S.K., Fullas, F., Brown, D.M., Wani, M.C., Wall, M.E., Cai, L., Mar, W., Luo, Y., Zaw, K., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Pentacyclic Triterpenoids from Maprounea africana as Potential Inhibitors of Chemical Carcinogenesis. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Wall, M.E., Wani, M.C., Fullas, F., Oswald, J.B., Brown, D.M., Santisuk, T., Reutrakul, V., McPhail, A.T., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., and Besterman, J.M. Calycopterones: Three Novel Cytotoxic Biflavonoid Constituents of Colycopteris floribunda. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Wright, A., Konig, G., Angerhofer, C.K., and Pezzuto, J.M. Antimalarial Activity: Collection and Investigation of Marine Organisms for Their Potential as Sources of New Leads for Antimalarial Compounds. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Pensuparp, T., Cai, L., Fong, H.H.S., Ingolfsdottir, K., Wagner, H., Lin, L.-Z., Kinghorn, A.D., Pezzuto, J.M., and Cordell, G.A. Natural Products Derived from Plants that Demonstrate Potent Inhibition of HIV-1 Reverse Transcriptase. International Research Congress on Natural Products and 35th Annual Meeting of the American Society of Pharmacognosy, Halifax, Nova Scotia, July 31-August 4, 1994.

Leaman, D.J., Soedjito, H., and Pezzuto, J.M. Borneo Antimalarials: Ethnobotany and Phytochemistry. 1994 Meeting of the Phytochemical Society of North America, Mexico City, Mexico, August 14-18, 1994.

Pezzuto, J.M. Natural Product Cancer Chemopreventive Agents. 1994 Meeting of the Phytochemical Society of North America, Mexico City, Mexico, August 14-18, 1994.

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Marles, R.J., Sanou-Pazos, L., Compadre, C.M., Compadre, R.L., Arnason, J.T., Durst, T., Awang, D.V.C., Pezzuto, J.M., and Fischer, M.H., Appendino, G., Drozdz, B., Bloszyk, E., Nowak, G., and Grabarczyk, H. Sesquiterpene Lactones Revisited: Recent Developments in the Assessment of Biological Activities and Structure Relationships. 1994 Meeting of the Phytochemical Society of North America, Mexico City, Mexico, August 14-18, 1994.

Brown, D.M., Wani, M., Wall, M.E., Ransom, A.C., Kinghorn, A.D., and Pezzuto, J.M. Induction of Apoptosis in Human Cancer Cell Lines by the Aqueous Partition of Plant Extracts. Conference entitled New Cancer Strategies: Apoptosis-Based Therapies, San Diego, September 1994.

Pezzuto, J.M. Natural Product Inhibitors of Carcinogenesis. Faculty of Science, Mahidol University, Bangkok, Thailand, September 29, 1994

Pezzuto, J.M. Discovery and Isolation of Natural Product Chemopreventive Agents. National Cancer Institute, Laboratory of Chemoprevention (Dr. M.B. Sporn), October 6, 1994.

Pezzuto, J.M. Natural Product Antitumor Drug Discovery as a Multidisciplinary Effort. Congreso Nacional de Ciencias Farmaceuticas, Los Cabos, Baja California, Mexico, October 23-26, 1994.

Gerhäuser, C., Lee, S.K., Kosmeder, J., Moriarty, R.M., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Transcriptional Regulation Mediated by Potent Rotenoid Chemopreventive Agents. Proc. Am. Assoc. Cancer Res., 36: 591, 1995 (86th Annual Meeting of the American Association for Cancer Research, Toronto, Canada, March 19-22, 1995).

Gerhäuser, C., You, M., Liu, J., Moriarty, R.M., Rundhaugen, L.M., Barch, D.H., and Pezzuto, J.M. Transcriptional Regulation of Drug Metabolizing Enzymes by Brassinin and Derivatives. Proc. Am. Assoc. Cancer Res., 36: 590, 1995 (86th Annual Meeting of the American Association for Cancer Research, Toronto, Canada, March 19-22, 1995).

Pezzuto, J.M. Bioassay-Directed Discovery of Natural Product Cancer Chemopreventive Agents. Invited presentation in the symposium "Natural Product Cancer Chemopreventive Agents," Proc. Am. Assoc. Cancer Res., 36: 705-706, 1995 (86th Annual Meeting of the American Association for Cancer Research, Toronto, Canada, March 19-22, 1995).

Seo, E.-K., Chai, H.-B., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Flavanones from the Leaves of Monotes engleri. Thirty-third Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, May 19-21, 1995.

Lee, S.K., Constant, H.L., Pezzuto, J.M., and Beecher, C.W.W. Identification of Antioxidants from Davidsonia pruriens and Curcuma longa using HPLC/MS. Thirty-third Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, May 19-21, 1995.

Krol, E.S., Huang, Z., Pisha, E., Pezzuto, J.M., and Bolton, J.L. Toxicity versus Therapeutic Efficacy: 4-Substituted Catechols as Mechanistic Probes for Oxidative Metabolism. Functional Foods for Health Conference, Chicago, IL, May, 1995.

Wongpanich, V., Angerhofer, C.K., El-Feraly, F.S., Vennerstrom, J.L., Makler, M.T., Pezzuto, J.M., and Cordell, G.A. Evaluation of Antimalarial Combinations Against Cultured Plasmodium falciparum. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

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You, M., Wickramaratne, D.B.M., Silva, G.L., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Bioassay-guided Isolation of Multiple Drug Resistance Reversing Agents from Plants. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Seo, E.-K., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Flavanones from the Leaves of Monotes engleri. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Luyengi, L., Suh, N., Fong, H.H.S., Mehta, R.G., Moon, R.C., Pezzuto, J.M., and Kinghorn, A.D. Potential Cancer Chemopreventive Agents from Brucea javanica. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Constant, H.L., Fang, L., Lee, S.K., Fong, H.H.S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D., and Beecher, C.W.W. Dereplication of Biologically Active Natural Products Using Electrospray HPLC/MS. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Suh, N., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Potent Chemopreventive Activity by Brusatol Isolated from Brucea javanica. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Pisha, E. and Pezzuto, J.M. Cell-based Assay Development for the Detection of Estrogenic and Anti-estrogenic Compounds. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Gerhäuser, C., Kennelly, E.J., Lee, S.K., Mar, W., Fong, H.H.S., Kinghorn, A.D., Mehta, R., Moon, R.C., and Pezzuto, J.M. Inhibition of Phorbol Ester-Induced Ornithine Decarboxylase (ODC) Activity in Cultured Mouse 308 Cells by 4'-Demethyl-Deoxypodophyllotoxin from Amanoa oblongifolia Stembark. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Gerhäuser, C., You, M., Liu, J., Moriarty, R.M., Rundaugen, L., Barch, D., and Pezzuto, J.M. Brassinin and Analogues Mediate Potent Chemopreventive Activity by Transcriptional Regulation of Drug-Metabolizing Enzymes. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Jang, M.S., Kennelly, E.J., Cai, L., Fong, H.H.S., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Bioassay-Directed Isolation of Potent Cyclooxygenase Inhibitors as Potential Cancer Chemopreventive Agents. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Lee, S.K., Kosmeder, II, J.W., Gerhäuser, C., Mar, W., Luyengi, L., Moriarty, R.M., Fong, H.H.S., Kinghorn, A.D., and Pezzuto, J.M. Structure-Activity Studies of Rotenoids that Inhibit Phorbol Ester-Induced Ornithine Decarboxylase (ODC) Activity in Cell Culture. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Tan, G.T., Lee, S.K., Lee, I.S., Chen, J., Besterman, J.M., Kinghorn, A.D., and Pezzuto, J.M. Natural Product Inhibitors of Human DNA Ligase I. 36th Annual Meeting of the American

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Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Huong, L.M., Angerhofer, C.K., Wongpanich, V., Tri, M.V., Xuan, L.T., Huong, P.T., Khanh, T.C., Chai, H.B., Soejarto, D.D., Fong, H.H.S., and Pezzuto, J.M. Evaluation of Antimalarial and Cytotoxic Activities of Vietnamese Plants. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Pisha, E., Gerhäuser, C., Chai, H., Lee, I.-S., Chagweder, T.E., Farnsworth, N.R., Cordell, G.A., Beecher, C.W.W., Fong, H.H.S., Kinghorn, A.D., Brown, D.M., Wani, M.C., Wall, M.E., Hieken, T.J., Das Gupta, T.K., and Pezzuto, J.M. Discovery of Betulinic Acid as a Selective Inhibitor of Human Melanoma that Functions by Induction of Apoptosis. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995 (invited presentation).

Sturm, S., Gil, R.R., Chai, H.B., Ngassapa, O.D., Santisuk, T., Reutrakul, V., Shen, J., Besterman, J.M., Yang, S.L., Farthing, J.E., Tait, R.M., O'Neill, M.J., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Lupane-Type Triterpenoids from Lophopetalum wallichii with Farnesyl Protein Transferase Inhibitory Activity. 36th Annual Meeting of the American Association of Pharmacognosy, University of Mississippi, Oxford, MS, July 23-27, 1995.

Krol, E.S., Huang, Z., Pisha, E., Ivenson, S., Pezzuto, J.M., and Bolton, J.L. Toxicity versus Therapeutic Efficacy: 4-Substituted Catechols as Mechanistic Probes for Oxidation Metabolism. Annual Meeting of the American Chemical Society, Chicago, IL, Aug. 20-24, 1995.

Moriarty, R.M., Kosmeder, II., J.W., Gerhäuser, C., Lee, S.K., Mar, W., and Pezzuto, J.M. Cancer Chemopreventive Agents: Synthesis and Structure/Activity Studies of Rotenoids as Antitumor Promoters. Annual Meeting of the American Chemical Society, Chicago, IL, Aug. 20-24, 1995.

Pengsuparp, T., Cordell, G.A., and Pezzuto, J.M. Discovery of Novel HIV-1 Reverse Transcriptase Inhibitors from Plants. Third International Conference on AIDS, Chiang Mai, Thailand, Sept. 17-21, 1995.

Pezzuto, J.M. Drugs that Prevent Disease: A Cost Effective Benefit Whose Time has Come. Fourth Annual Blue Cross Blue Shield Managing the Prescription Drug Benefit Meeting, Los Angeles, CA, Sept. 17-19, 1995.

Pezzuto, J.M. Novel Strategies for the Discovery of Natural Product Drugs. Centre de Recherche Pierre Fabre, Castres, France, October 17, 1995.

Pezzuto, J.M. Discovery of Natural Product Cancer Chemopreventive Agents. 1st World Congress on Advances in Oncology, Athens, Greece, October 22-26, 1995 [Int. J. Oncol., 7 (Suppl.): 985, 1995].

Wongpanich, V., Suh, N., Angerhofer, C.K., E.-Feraly, F.S., and Pezzuto, J.M. Artemisinin Derivatives as Inducers of Cell Differentiation. 44th Annual Meeting of the American Society of Tropical Medicine and Hygiene, San Antonio, TX, November 17-21, 1995.

Pezzuto, J.M. Bioassay-directed Isolation of Natural Product Drugs. Symposium entitled "Las plantas como fuente de medicamentos," Santo Domingo, Dominican Republic, December 9, 1995.

Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J.A., and Besterman,

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J.M. Novel Strategies for Plant-Derived Anticancer Agents. 6th International Symposium on Natural Products Chemistry, Karachi, Pakistan, Jan. 4-8, 1996.

Cordell, G.A., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., Chai, H.-B., Constant, H.L., Likhitwitayawuid, K., Shieh, H.-L., Wikramaratne, D.B.M., and You, M. Recent Studies on Biologically Active Natural Products. 6th International Symposium on Natural Products Chemistry, Karachi, Pakistan, Jan. 4-8, 1996.

Pezzuto, J.M., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., Hedayat, S., Udeani, G.O., and Moriarty, R.M. Novel Strategies for the Discovery of Natural Product Cancer Chemopreventive Agents. 6th International Symposium on Natural Products Chemistry, Karachi, Pakistan, Jan. 4-8, 1996.

Krol, E.S., Huang, Z., Pisha, E., Shen, L., Iverson, S., Pezzuto, J.M., and Bolton, J.L. Allyl Catechols which form Long-lived Quinoids are Cytotoxic towards Human Melanoma Cells. Society of Toxicology Meeting, Anaheim, CA, March 11-13, 1996.

Pezzuto, J.M. Methodology Necessary for Successful Drug Discovery. Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, March 13, 1996.

Pezzuto, J.M. Workshop on Cell Culture. Faculty of Science, Mahidol University, Bangkok, Thailand, March 15, 1996.

Pezzuto, J.M. Presentation of a series of three lectures dealing with biological methodology necessary for effective natural product drug discovery research programs, National Center for Sciences and Technology, Nghia Do, Tu Liem, Hanoi, Vietnam, March 17-21, 1996.

Gerhäuser, C., Kosmeder, II, J.W., Lee, S.K., Mar, W., Moriarty, R.M., and Pezzuto, J.M. Rotenoids as Cancer Chemopreventive Agents: Investigation of Mode of Action. 211th Annual Meeting of the American Chemical Association, New Orleans, LA, March 24-29, 1996.

Chang, L.-C., Gerhäuser, C., You, M., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Potential Cancer Chemopreventive Agents from Tephrosia purpurea. Thirty-fourth Annual Medicinal Chemistry Meeting-in-Miniature, Iowa City, Iowa, March 29-31, 1996.

Long, L., Lee, S.K., Chai, H.-B., Rasoanaivo, P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic Phenanthrenes from Domohinea madagascariensis. Thirty-fourth Annual Medicinal Chemistry Meeting-in-Miniature, Iowa City, Iowa, March 29-31, 1996.

Algranati, N., Shamon, L., Zhang, L., Moy, S., Zaw, K., Pezzuto, J.M., and Lu, M. Mechanism-based Endocrine Selective Tumor Inhibitors. Thirty-fourth Annual Medicinal Chemistry Meeting-in-Miniature, Iowa City, Iowa, March 29-31, 1996.

Pezzuto, J.M. Bioassay-Directed Discovery of Cancer Chemotherapeutic and Chemopreventative Agents from Natural Products, 12th International Conference on Advanced Science and Technology, Chicago, IL, April 6, 1996.

Udeani, G.O., Thomas, C.F., Kosmeder, J., Moriarty, R.M., Pezzuto, J.M., and Moon, R.C. Deguelin: A Natural Product for Chemoprevention. Proc. Am. Assoc. Cancer Res., 37: 275, 1996 (87th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April 20-24, 1996).

Gerhäuser, C., You, M., Liu, J., Moriarty, R.M., Mehta, R.G., Moon, R.C., and Pezzuto,

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J.M. Chemopreventive Potential of a Novel Sulforaphane Analog. Proc. Am. Assoc. Cancer Res., 37: 278, 1996 (87th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April 20-24, 1996).

Gerhäuser, C., Kosmeder, J., Lee, S.K., Moriarty, R.M., and Pezzuto, J.M. Mechanistic Investigation of Rotenoid-Mediated Cancer Chemopreventive Activity. Proc. Am. Assoc. Cancer Res., 37: 278, 1996 (87th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April 20-24, 1996).

Jang, M.S., Lee, S.K., You, M., Suh, N., Pisha, E., Shamon, L., Cai, L., Kinghorn, A.D., Mehta, R.G., and Pezzuto, J.M. Resveratrol, a Novel Dietary Cancer Chemopreventive Agent. Proc. Am. Assoc. Cancer Res., 37: 278, 1996 (87th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April 20-24, 1996).

Shamon, L.A., Mehta, R.R., Das Gupta, T.K., and Pezzuto, J.M. Evaluation of Natural Products as Inhibitors of HER-2/neu. 87th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April 20-24, 1996.

Pezzuto, J.M. In Vitro Models of Human Disease States, American Association of Pharmaceutical Scientists Midwest Regional Meeting, Chicago, IL, May 20, 1996.

Schmidt, M.L., Kuzmanoff, K.M., Ling-Indeck, L., and Pezzuto, J.M. Betulinic Acid Induces Apoptosis in Human Neuroblastoma Cell Lines. International Symposium on Advances in Neuroblastoma Research, Philadelphia, PA, May 22-25, 1996.

Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, M.C., O'Neill, M.J., Lewis, J.A., and Besterman, J.M. Novel Strategies for Plant-Derived Anticancer Agents. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996 (invited).

Graham, J., Constant, H.L., Pezzuto, J.M., and Beecher, C.W.W. Quantitation of Betulinic Acid in Birch (Betula sp.) Twigs. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Balandrin, M.F., Van Wagenen, B.C., Roeloffs, R., Albensi, B.C., Wirtshafter, D., Shieh, H.-L., Pezzuto, J.M., and Cordell, G.A. Valerian-Derived Sedative Agents. III. Iso-Valeramide, a Novel Anxiolytic Agent from Valerian-Derived Isovaleric Acid Esters (Valeriana spp., Valerianceae). 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Constant, H.L., Graham, J., Slowing, K.V., Schilling, A.B., Pezzuto, J.M., Cordell, G.A., and Beecher, C.W.W. The Use of Collision-Induced Dissociation in the Dereplication of Flavonoid Glycosides. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Silva, G.L., Gil, R.R., Cui, B., Chai, H., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic Ring-A Seco-Cycloartane Triterpenes from Gardenia coronaria. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

110

Chang, L.-C., Gerhäuser, C., Song, L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Potential Cancer Chemopreventive Agents from Tephrosia purpurea. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Long, L., Lee, S.K., You, M., Chai, H.-B., Rasoanaivo, P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel Cytotoxic Phenanthrenoids from Domohinea perrieri. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Kennelly, E.J., Gerhäuser, C., Graham, J.G., Beecher, C.W.W., Pezzuto, J.M., and Kinghorn, A.D. Withanolides from Physalis philadelphica as Potential Cancer Chemopreventive Agents. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Lee, S.K., Constant, H.L., Graham, J.G., Mbwambo, Z.H., Farnsworth, N.R., Kinghorn, A.D., Beecher, C.W.W., and Pezzuto, J.M. Evaluation of the Antioxidant Potential of Plant Extracts and Identification of Active Principles Using HPLC/MS Dereplication Analysis. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Çaliş, İ., Yürüker, A., Taşdemir, Wright, A.D., Sticher, O., Luo, Y.-D., and Pezzuto, J.M. Stimulation of Human Lymphocytes Mediated by Saponins. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Mata-Greenwood, E., Mehta, R.G., Ito, A., Yu, B., Kosmeder, II, J.W., Moriarty, R.M., Kinghorn, A.D., and Pezzuto, J.M. Flavone and Chalcone Inducers of HL-60 Cell Differentiation. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Mata-Greenwood, E., McChesney, J.D., Kinghorn, A.D., and Pezzuto, J.M. Structure-Activity Relationships of Quassinoids that Induce HL-60 Cell Differentiation. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Shamon, L.A., Mehta, R.R., Das Gupta, T.K., and Pezzuto, J.M. Natural Product Inhibitors of HER-2/neu Tyrosine Kinase. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Lee, H.W. and Pezzuto, J.M. Development of a Rapid and Inexpensive Screening Method for Potential Anticancer Agents Using the Marine Dinoflagellate Crypthecodinium cohinii. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Gerhäuser, C., Kosmeder, J.W., Song, L., Hawthorne, M., Mehta, R., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Chalcones Induce Drug-Metabolizing Enzymes in Vitro and in Vivo. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Jang, M.S., Cai, L., Lee, S.K., Suh, N., Gerhäuser, C., Shamon, L., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Discovery of a Novel Dietary Cancer Chemopreventive Agent that Inhibits Cyclooxygenase Activity. 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

Horgen, F.D., Guinaudeau, H., Angerhofer, C.K., Pezzuto, J.M., Farnsworth, N.R., Reutrakul, V., and Santisuk, T. Isolation of Antimalarial and Cytotoxic Alkaloids of Mahonia siamensis Takeda (Berberidaceae). 37th Annual Meeting of the American Society of Pharmacognosy, Santa Cruz, CA, July 27-31, 1996.

111

Pezzuto, J.M. Selective Evaluation of Natural Product Drugs Utilizing in Vitro Bioassay Systems. Sandoz Pharma AG, Basel, Switzerland, Sept. 9, 1996.

Gerhäuser, C., Kosmeder, J.W., Moriarty, R.M., Thomas, C.F., Moon, R.C., and Pezzuto, J.M. Chemoprevention by Deguelin: Inhibition of Phorbol Ester-Induced Ornithine Decarboxylase Activity in Mouse Skin. International Meeting on Cancer Chemoprevention: Molecular Basis, Mechanisms and Trials, Heidelberg, Germany, Sept. 9-11, 1996.

Gerhäuser, C., You, M., Liu, J., Moriarty, R.M., Hawthorne, M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Cancer Chemopreventive Potential of a Novel Analog of Sulforaphane That Induces Phase 2 Drug-Metabolizing Enzymes. 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytotherapy, Munich, Germany, Sept. 11-14, 1996.

Asakawa, Y., Hashimoto, T., Nagashima, F., Toyota, M., Pezzuto, J.M., and Cordell, G.A. Biologically Active Terpenoids and Bibenzyl Derivatives from Liverworts. 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytotherapy, Munich, Germany, Sept. 11-14, 1996.

Grzybek, J., Cordell, G.A., and Pezzuto, J.M. Evaluation of Antiviral and Cytotoxic Activities of Selected Polish Plant Species. Congress on the Future Direction of Drug Investigations, Polish Committee of Scientific Investigations, Kraków, Poland, Sept. 12-13, 1996.

Cui, B., Chai, H.-B., Tucker, J.C., Beecher, C.W.W., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Four Novel Cytotoxic Sesquiterpenoids from the Flowers of Ratibida columnifera. 20th IUPAC Symposium on the Chemistry of Natural Products, Chicago, IL, Sept. 15-20, 1996.

Pisha, E., Luyengi, L., Lee, S.K., Farnsworth, N.R., Mehta, R.G., Moon, R.C., Kinghorn, A.D., and Pezzuto, J.M. Potential Cancer Chemopreventive Lignans from Cerbera manghas. 20th IUPAC Symposium on the Chemistry of Natural Products, Chicago, IL, Sept. 15-20, 1996.

Funayama, S., Noshita, T., Aoyagi, T., Tadauchi, K., Pan, T.-Y., Nozoe, S., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Chemical Reactions of Acronycine and Related Compounds. 38th Symposium on the Chemistry of Natural Products, Sendai, Japan, Oct. 14-16, 1996 (Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 1996, 38th, 553-558).

Gerhäuser, C., Liu, J., Moriarty, R.M., Hawthorne, M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Anticarcinogenic Potential of a Novel Analog of Sulforaphane that Induces Phase 2 Drug-Metabolizing Enzymes. 5th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, Okayama, Japan, Dec. 2-6, 1996.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive and Chemotherapeutic Agents. International Joint Symposium. Chemistry, Biological and Pharmacological Properties of Medicinal Plants from the Americas, Panama City, Panama, Feb. 23-26, 1997.

Pezzuto, J.M. Strategies for the Discovery of New Natural Product Cancer Chemopreventive Agents. Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago, March 19, 1997.

Pezzuto, J.M. Cancer Chemoprevention and the General Population. Chicago Division of Mensa, Lisle, IL, March 29, 1997.

Song, L., Lantvit, D., Lubet, R.A., Steele, V.E., Kelloff, G.J., Pezzuto, J.M., and Moon, R.C.

112

Chemoprevention of Mammary Carcinogenesis by Inducers of Phase II Enzymes. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997.

Song, L., Kosmeder, J.W., Gerhäuser, C., Hawthorne, M., Mehta, R.G., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Potent Induction of Phase II Enzymes by Flavones and Chalcones. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997.

Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997.

Gerhäuser, C., Thomas, C.F., Moon, R.C., and Pezzuto, J.M. Brassinin-mediated Induction of Phase II Detoxification Enzymes in Rat Liver and Mammary Glands. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997.

Pisha, E., Chang, L.-C., Kinghorn, A.D., Hawthorne, M., Mehta, R.G., and Pezzuto, J.M. Identification of Novel Anti-Estrogenic Chemopreventive Agents from Natural Products. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA, April 12-16, 1997.

Pezzuto, J.M. Resveratrol, a Cancer Chemopreventive Constituent of the Grape. Meeting of the California Table Grape Commission, Bakersfield, CA, April 17, 1997.

Pezzuto, J.M. Natural Product Drug Discovery and Characterization Employing in Vitro Models of Human Disease States. 1st Congress of Pharmaceutical Sciences, Ribeirão Preto, São Paulo, Brazil, April 20-24, 1997.

Pezzuto, J.M. Discovery and Characterization of Natural Product Drugs, NIAID, Rocky Mountain Laboratories, Hamilton, MT, May 9, 1997.

Chatterjee, P., Pezzuto, J.M., and Kouzi, S.A. Microbial Models of Mammalian Metabolism: Biotransformation of the Antimelanoma Agent Betulinic Acid. 24th Annual MALTO meeting, University of Arkansas, Little Rock, Arkansas, May 18-20, 1997.

Pezzuto, J.M. Discovery of Cancer Chemopreventive Agents of Relevance to Human Health. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997 (invited).

Kosmeder, II, J.W., Song, L., Gerhauser, C., Moriarty, R.M., and Pezzuto, J.M. Cancer Chemopreventive Agent Drug Discovery: Flavonoid Inducers of Detoxification Enzymes. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Lee, S.K., Jeong, H.J., and Pezzuto, J.M. Inhibition of Aromatase Activity by Capsaicinoids. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Mata-Greenwood, E., Shamon, L.A., Lee, S.K., Ito, A., Yu, B., Kinghorn, A.D., and Pezzuto, J.M. Potential Chemopreventive Agents from Casimiroa edulis. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

113

Pisha, E., Chang, L.-C., Kinghorn, A.D., Hawthorne, M., Mehta, R.G., and Pezzuto, J.M. Identification of Novel Anti-Estrogenic Chemopreventive Agents from Natural Products. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Song, L., Kosmeder, J.W., Gerhauser, C., Hawthorne, M., Mehta, R.G., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Potential Chemopreventive Effects of Flavones and Chalcones by Induction of Phase II Enzymes. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Westenburg, H.E., Mata-Greenwood, E., Soejarto, D.D., Pezzuto, J.M., and Kinghorn, A.D. Aryl Polysulfides of Petiveria alliacea and Their Synthetic Analogs which Induce HL-60 Cell Differentiation and Quinone Reductase. Functional Foods for Health, 6th Annual Retreat, Lake Bluff, IL, May 19-21, 1997.

Pezzuto, J.M. The Value of Natural Products in the Prevention of Cancer. AIC Conference entitled "Scientific Breakthroughs and Commercial Opportunities in Nutraceuticals," Chicago, IL, May 29-30, 1997.

Pezzuto, J.M., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., Hedayat, S., Udeani, G.O., and Moriarty, R.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Congress on In Vitro Biology, 1997 Meeting of the Society for In Vitro Biology, Washington, D.C., June 14-18, 1997 (In Vitro Cellular & Developmental Biology, 33 (Part II): 2A, 1997).

Yang, S.-W., Cordell, G.A., Chai, H.B., and Pezzuto, J.M. Metabolic Studies with Streptomyces staurosporeus, a Staurosporine Producer. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Westenburg, H.E., Mata-Greenwood, E., Song, L., Castillo, J.J., Soejarto, D.D., Pezzuto, J.M., and Kinghorn, A.D. Naturally Occurring and Synthetic Aryl Polysulfides with Activity in HL-60 Cell Differentiation and Quinone Reductase Induction Assays. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Jeong, H.-J., Song, L., Kinghorn, A.D., and Pezzuto, J.M. Aromatase Inhibitors from Isodon excisus var. coreanus. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Qiu, S., Sun, H., Lobkovsky, E., Chai, H., Fong, H.H.S., Clardy, J., Pezzuto, J.M., and Farnsworth, N.R. A Cytotoxic Diterpene from Isodon megathyrsus (Labiatae). 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Wongpanich, V., Mata-Greenwood, E., Suh, N., Chai, H., Fong, H.H.S., Pezzuto, J.M., and Angerhofer, C.K. Correlation of the Antimalarial Activity of Artemisinins and Their Potential to Induce Cell Differentiation. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Mata-Greenwood, E., Grieco, P.A., and Pezzuto, J.M. Cell Differentiation and Regulation of Oncogene Expression by Selected Quassinoids. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Lee, S.K., Cui, B., Chai, H.-B., Pisha, E., Farnsworth, N.R., Kinghorn, A.D., and Pezzuto, J.M. Cytotoxic Mechanism Mediated by Novel 1H-Cyclopentatetrahydro(b)-benzofurans Isolated from Aglaia elliptica. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

114

Chang, L.-C., Pisha, E., Kennelly, E.J., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antiestrogenic Steroidal Alkaloids from Pachysandra procumbens. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Ito, A., Shamon, L.A., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antimutagenic Constituents of Casimiroa edulis. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Soejarto, D.D., Cordell, G.A., Farnsworth, N.R., Fong, H.H.S., Kinghorn, A.D., and Pezzuto, J.M. International Collaborative Projects at PCRPS (Program for Collaborative Research in the Pharmaceutical Sciences). 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Jang, M.S., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Resveratrol, a Novel Natural Cancer Chemopreventive Agent. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997 (invited lecture).

Chung, H.S., Mbwambo, Z.H., Shamon, L.A., Beecher, C.W.W., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Potent Antimutagenic Constituents of Mezoneuron cucullatum. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Chung, H.S., Lee, S.K., Shamon, L.A., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Novel Antioxidant Flavonoids from Chorizanthe diffusa. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Carcache Gamez, E.J., Luyengi, L., Lee, S.K., Zhu, L.F., Zhou, B.-N., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Potential Cancer Chemopreventive Agents from Daphniphyllum calycinum. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Cui, B., Chai, H., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Four Novel Cytotoxic 1H-Cyclopentatetrahydro(b)benzofuran Lignans from Aglaia elliptica. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Cui, B., Chai, H., Constant, H.L., Santisuk, T., Reutrakul, V., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Chemical and Biological Investigation of Limonoids from Azadirachta excelsa. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Kim, D.S.H.L., Pezzuto, J.M., and Pisha, E. Development of Betulinic Acid Based Antitumor Agent Against Human Melanoma. 38th Meeting of the American Society of Pharmacognosy, Iowa City, Iowa, July 26-30, 1997.

Pezzuto, J.M. In Vitro Models of Human Disease States, Division of Medicine Grand Rounds, Univ. Texas M.D. Anderson Cancer Center, Houston, TX, Aug. 12, 1997.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents, Univ. Texas M.D. Anderson Cancer Center, Houston, TX, Aug. 13, 1997.

115

Gerhauser, C., Kosmeder, J.W., Moriarty, R.M., Hamel, E., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Regulation of Ornithine Decarboxylase Induction Mediated by Deguelin, a Natural Product Cancer Chemopreventive Agent. International Society of Cancer Chemoprevention, 2nd Annual Conference, St. Gallen, Switzerland, Aug. 28-30, 1997.

Pezzuto, J.M., Jang, M.S., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W.W., Fong, H.S.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., and Moon, R.C. Cancer Chemopreventive Activity of Resveratrol, a Component of Grapes and Grape-derived Products. First International Scientific Congress "Wine and Health," Fundacion para la Investigacion del Vino, Madrid, Spain, Oct. 2-3, 1997.

Pezzuto, J.M., Jang, M.S., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W.W., Fong, H.S.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., and Moon, R.C. Cancer Chemopreventive Activity of Resveratrol. New Anticancer Agents, International Institute of Anticancer Research, Athens, Greece, Oct. 12-15, 1997 (Anticancer Res., 17: 4092, 1997).

Pezzuto, J.M. Natural Products: The Backbone of Prototype Drug Discovery. American Association of Pharmaceutical Scientists Annual Meeting, Boston, MA, Nov. 2-6, 1997.

Pezzuto, J.M. Alternative Medicines for Cancer Chemoprevention, American Society of Health-System Pharmacists Midyear Meeting, Atlanta, GA, Dec. 7-11, 1997.

Pezzuto, J.M. Natural Product Drug Discovery in an Academic Environment. Interdisciplinary Environmental Toxicology Seminar Series, University of Illinois at Urbana-Champaign, Urbana, Illinois, December 12, 1997.

Pezzuto, J.M. Cancer Chemoprevention. American College of Obstetricians and Gynecologists, Gynecologic Oncology Group, Seattle, WA, January 17, 1998.

Pezzuto, J.M. Cancer Chemopreventive Activity of Resveratrol, Welch's Oncology Advisory Group, New York, NY, January 20, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Rutgers University, New Brunswick, NJ, January 21, 1998.

Pezzuto, J.M. Health Quest Symposium on natural anti-cancer compounds, Cancer Chemopreventive Activity of Resveratrol, Anaheim, CA, March 14, 1998.

Pezzuto, J.M. Medicines from Natural Products: From Discovery to Development (Complementary Medicine Program, Science Symposium), American Pharmaceutical Association, Miami, FL, March 21-25, 1998.

Rauth, S., Boddie, E., Pezzuto, J., Pisha, E., and Green, A. Inductions of p53, p21, and MDM2 are Associated with G2/M Arrests in Metastatic Melanoma Cells Treated with Genistein in Vitro. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998.

Pisha, E., Pezzuto, J.M., Rauth, S., Das Gupta, T.K. Melanoma Cell Cycle Perturbations by Betulinic Acid. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998.

Mata-Greenwood, E., Mehta, R.G., Grieco, P.A., and Pezzuto, J.M. Effects of Antineoplastic Quassinoids on the Growth and Differentiation of HL-60 Cells. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998.

116

Lee, S.K., Mbwambo, Z.H., Suh, N., Kinghorn, A.D., and Pezzuto, J.M. Potential Tumor Promoter Activity Mediated by a Novel Ingenol Ester from Euphorbia quinquecostata. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998.

Song, L., Kosmeder, J.W., Lantvit, D., Kennedy, C., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. 4'-Bromoflavone, a Potential Chemopreventive Agent That Strongly Induces Phase II Enzymes. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998 (presented in mini-symposium).

Udeani, G.O., Zhao, G.M., Beecher, C.W.W., Moon, R.C., Kinghorn, A.D., and Pezzuto, J.M. Preclinical Pharmacokinetics of Deguelin, a Naturally Occurring Chemopreventive Agent. 89th Annual Meeting of the American Association of Cancer Research, New Orleans, March 28-April 1, 1998.

Pezzuto, J.M., Angerhofer, C.K., and Mehdi, H. Discovery and Characterization of Natural Product Drugs. 142th International Conference on Advanced Science and Technology, Naperville, IL, April 4, 1998.

Pezzuto, J.M. Natural Inhibitors of Carcinogenesis. Monsanto Life Sciences, St. Louis, MO, April 7, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Drugs, Geraldine Brush Cancer Research Institute, San Francisco, CA, April 20, 1998.

Pezzuto, J.M. Inhibition of Carcinogenesis by Natural Products Derived from Plants (Symposium entitled Herbal Medicine: Current Status of Use and Research in the U.S.), American Society for Pharmacology and Experimental Therapeutics, Symposium, San Francisco, CA, April 18-22, 1998.

Symposium sponsored by the California Table Grape Commission, lecture and co-organizer, San Francisco, CA, April 30-May 1, 1998 (published as a supplement to Vol. 36 of Pharm. Biol.).

Pezzuto, J.M. Discovery of Natural Product Drugs in an Academic Environment. XIIth International Symposium on Plant Originated Crude Drugs. Hacettepe University, Ankara, Turkey, May 20-22, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Drugs. Collaborative Research Programs in Organic Synthesis and Bioactive Natural Products Drugs. Mahidol University, Bangkok, Thailand, May 30, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Division of Cancer Chemoprevention, National Cancer Institute, June 11, 1998.

Pezzuto, J.M. Survey of Ethnomedical Data, Chemical Constituents, and Biological Activities of Glycine max. Consortium on Human Health and Soybeans, Chicago, Illinois, July 13-14, 1998.

Fang, L., Mi, Q., Chai, H., Madulid, D.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic dichapetalin-type triterpenoids from Dichapetalum gelonioides. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

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Cui, B., Chai, H., Madulid, D.R., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Quinoline alkaloids from Acronychia laurifolia. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Shin, Y.G., Cho, K.H., Chung, S.M., Graham, J., Das Gupta, T.K., and Pezzuto, J.M. Determination of betulinic acid in mouse blood, tumor and tissue homogenates by HPLC-electrospray/MS. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Bhat K.P.L., Mehta, R.G., and Pezzuto, J.M. Potent inhibition of estrone sulfatase by naturally occurring triterpenoids. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Jeong, H.-J., Kinghorn, A.D., and Pezzuto, J.M. Aromatase inhibitors from Isodon excisus var. coreanus. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Gills, J., Luyengi, L., Mehta, R.G., Farnsworth, N.R., Kinghorn, A.D., and Pezzuto, J.M. Antiproliferative lignans from Cerbera manghas. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Chang, L.-C., Bhat, K.P.L., Pisha, E., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Additional antiestrogen binding site inhibitory steroidal alkaloids from Pachysandra procumbens. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Lee, S.K., Qing, W.G., Mar, W., Luyengi, L., Mehta, R.G., Kawanish, K., Fong, H.H.S., Beecher, C.W.W., Kinghorn, A.D., and Pezzuto, J.M. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Chatterjee, P., Pezzuto, J.M., and Kouzi, S.A. Microbial models of mammalian metabolism: biotransformation of the antimelanoma agent betulinic acid. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Calderón, A.I., Buitrago de Tello, R., Pezzuto, J.M., Espósito, M., Sanchez, C., and Gupta, M.P. Anti-inflammatory and analgesic activities of Vochysia ferruginea. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Jeong, H.-J., Chai, H.-B., Pezzuto, J.M., and Kim, D.S.H.L. Development of betulinic acid based antitumor agent against human melanoma. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Kim, D.-S., Jeong, H.-J., Bhat, K.P.L., Pezzuto, J.M., Krueger, R.J., and Kim, D.S.H.L. Discovery of aromatase and sulfatase inhibitors from Lepiota americana. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Shin, Y.G., Cordell, G.A., Chai, H.-B., Dong, Y., Pezzuto, J.M., Venkata, A., Rao, N.A., Ramesh, M., Kumar, B.R., and Radhakishan, M. Rapid identification of cytotoxic alkenyl catechols in Semecarpus anacardium using bioassay-linked HPLC-electrospray/MS analysis. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

Horgen, F.D., Guinaudeau, H., Pezzuto, J.M., Soejarto, D.D., Farnsworth, N.R., Agcaoili, F., de Los Reyes, G., and Edrada, R.A. Alkenylresorcinols from Ardisia iwahigensis. 39th Meeting of the American Society of Pharmacognosy, Orlando, Florida, July 19-24, 1998.

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Pezzuto, J.M. Lecture entitled "Evaluating Plant Extracts for Cancer Chemopreventive Activity" and "Cancer Inhibiting Effects of Resveratrol, a Compound Found in Grapes and Grape Wine," Annual Meeting of the North Carolina Grape Grower's Association, Wilmington, NC, July 31, 1998.

Pezzuto, J.M. Natural Product Drug Discovery in an Academic Environment. Sustainable Development and Conservation of Biodiversity in Vietnam, National Center for Science and Technology, Hanoi, Vietnam, October 2-3, 1998.

Jang, M. and Pezzuto, J.M. Cancer Chemopreventive Activity of Resveratrol. International Congress on Wine and Health, Florence, Italy, November 26-28, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Drugs, University of Salerno, Salerno, Italy, December 3, 1998.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Department of Immunology/Microbiology, Rush Medical Center, Chicago, Illinois, December 14, 1998.

Pezzuto, J.M. Discovery of Cancer Chemopreventive Agents from Natural Products, Harvard Medical School Symposium on Nutrition and Health, Daniel Tosteson Medical Education Center, Harvard Medical School, Boston, MA, March 18-20, 1999.

Lee, S.K., Steele, V.E., Kelloff, G.J., and Pezzuto, J.M. Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Proc. Am. Assoc. Cancer Res. 40: 55, 1999.

Mata-Greenwood, E. and Pezzuto, J.M. Brusatol, a natural product that induces HL-60 cell differentiation and growth arrest, mediates its effects through an increase in cAMP and a decrease in purine levels. Proc. Am. Assoc. Cancer Res. 40: 127, 1999.

Bhat, K.P.L., Steele, V.E., Kelloff, G.J., Pezzuto, J.M., and Mehta, R.G. Selective suppression of alveolar and ductal preneoplastic mammary lesions by chemopreventive agents. Proc. Am. Assoc. Cancer Res. 40: 304, 1999.

Udeani, G.O., Shin, Y.G., Zhao, G.M., Koch, R.L., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Initial mouse and human skin tissue pharmacokinetic evaluation of the antimelanoma agent--betulinic acid. Proc. Am. Assoc. Cancer Res. 40: 388, 1999.

Salti, G.I., Das Gupta, T.K., Mehta, R.G., Bratescu, L., Kichina, J.V., Pezzuto, J.M., and Constantinou, A.I. The effect of betulinic acid on dysplastic and congenital nevi cells: Evidence for a potential role as a chemopreventive agent. Proc. Am. Assoc. Cancer Res. 40: 433, 1999.

Swanson, S.M., Cho, K.H., Shin, Y.G., Pezzuto, J.M., and Das Gupta, T.K. Betulinic acid does not require metabolic activation to induce apoptosis in melanoma cells. Proc. Am. Assoc. Cancer Res. 40: 488, 1999.

Lubet, R.A., Mehta, R.G., Pezzuto, J.M., Steele, V.E., Kelloff, G.J., and Grubbs, C.J. Effects of the Ah receptor agonist 5,6-benzoflavone (BF) on methylnitrosourea (MNU) and dimethylbenzanthracene (DMBA) induced mammary cancers. Proc. Am. Assoc. Cancer Res. 40: 653, 1999.

Pezzuto, J.M. Chemoprevention and Risk Reduction, Women's Health Issues: A

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Multidisciplinary Approach, Center for Excellence in Women's Health, UIC, Chicago, April 16, 1999.

Pezzuto, J.M., Kosmeder, J.W., Lee, S.K., Mbwambo, Z.H., Chung, H.S., Luyengi, L., Gamez, L.E.J.C., Mehta, R.G., Kinghorn, A.D., and van Breemen, R.B. Evaluation of the antioxidant potential of natural products. 8th Annual Functional Foods for Health Retreat, Indian Lakes Resort, Bloomingdale, IL. May 17-19, 1999.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. CU-Hauser Natural Products Chemistry Symposium. University of Colorado at Boulder, Boulder, CO, May 19-21, 1999.

Pezzuto, J.M. Natural Product Cancer Chemopreventive Agents, Chicago Experimental Group, Northwestern University, Chicago, IL, June 23, 1999.

Bhat, K.P.L. and Pezzuto, J.M. Evaluation of Resveratrol as a Selective Estrogen Receptor Modulator. FIVIN 2nd International Scientific Congress, "Wine and Health", Madrid, Spain, Oct. 21-22, 1999.

Pezzuto, J.M. Discovery and Characterization of Novel Natural Products that may be of Value in the Prevention of Human Cancer, International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC meeting), presented in workshop entitled "Prevention Targets," Washington, DC, Nov. 16-19, 1999.

Bhat, K.P.L., Mehta, R.G., and Pezzuto, J.M. Evaluation of Resveratrol as a Selective Estrogen Receptor Modulator: In Vitro and In Vivo Studies. Proceedings of the 15th Asia Pacific Cancer Conference. 15: 204, 1999.

Pezzuto, J.M. Cancer Chemoprevention: A Perspective for the Future, 21st Annual Eino Nelson Memorial Conference, presented in session entitled "Nutraceuticals-Herbal Products," St. Petersburg, Florida, January 23-26, 2000.

Pezzuto, J.M. Natural Inhibitors of Carcinogenesis, Department of Hematology/ Oncology Seminar Series, College of Medicine, UIC, February 3, 2000.

Pezzuto, J.M. and Das Gupta, T.K. Therapeutic Application of Betulinic Acid in Melanoma, presented betulinic acid RAID application at the National Cancer Institute, Bethesda, MD, March 15, 2000.

Bhat, K.P.L. and Pezzuto, J.M. Potent inhibition of estrone sulfatase by naturally occurring triterpenoids. Proc. Am. Assoc. Cancer Res. 41: 310, 2000.

Constantinou, A.I., Rossi, H., Nho, C.-W., Jefferey, E.H., Xu, X., van Breemen, R.B., and Pezzuto, J.M. Soy protein isolate depleted of isoflavones prevents DMBA-induced mammary tumors in female rats. Proc. Am. Assoc. Cancer Res. 41: 310, 2000.

Gills, J.J., Tamez, P.A., and Pezzuto, J.M. Deguelin induces apoptosis in MCF-7 cells and affects the expression of genes involved in stress, apoptosis, signal transduction and DNA repair. Proc. Am. Assoc. Cancer Res. 41: 833, 2000.

Gustin, D.M., Stock, W., Mata-Greenwood, E., Sher, D., and Pezzuto, J.M. Brusatol and bruceantin, novel plant-derived quassinoids, induce differentiation in a variety of leukemia cell lines. Proc. Am. Assoc. Cancer Res. 41: 544, 2000.

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Shin, Y.G., Lee, D.H., Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D., and Udeani, G.O. Development of an analytical method for the detection of the potential anticancer agent: 13-methoxy-15-oxozoapatlin. Proc. Am. Assoc. Cancer Res. 41: 103, 2000.

Starr, F.L., Kosmeder, J., Rossi, H.L., Salti, G.I., Pezzuto, J.M., Das Gupta, T.K., and Mehta, R.G. Deguelin, an inducer of apoptosis, is a potent growth inhibitor of human melanoma cells. Proc. Am. Assoc. Cancer Res. 41: 601, 2000.

Swanson, S.M., Cho, K.H., Chen, C., Pezzuto, J.M., and Das Gupta, T.K. Betulinic acid induced cell death is independent of P53 in human melanoma cells. Proc. Am. Assoc. Cancer Res. 41: 509, 2000.

Chang, L.C., Song, L.L., Park, E.J., Luyengi, L., Lee, K.J., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Bioactive Constituents of Thuja occidentalis. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Chatterjee, P., Kouzi, S.A., Pezzuto, J.M., and Hamann, M.T. Microbial transformations of the antimelanoma agent betulinic acid. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Chávez, D., Chai, H.-B., Chagwedera, T.E., Gao, Q., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel Stilbenes Isolated from the Root Bark of Ekebergia benguelensis. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Cuendet, M., Gills, J.J., Tamez, P.A., and Pezzuto, J.M. Modulation of Gene Expression in Leukemic Cell Lines HL-60 and NB4 Treated with Brusatol. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

El Sayed, K.A., Dunbar, D.C., Hamann, M.T., Mayer, A.M.S., and Pezzuto, J.M. Microbial Transformation of Marine Natural Products. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Gu, J., Park, E.J., Mehta, R.G., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Eugenia sandwicensis with Potential Cancer Chemopreventive Activity. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Ito, A., Cui, B., Chávez, D., Chai, H.-B., Shin, Y.G., Kardono, L.B.S., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Constituents of Ochanostachys amentacea. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Lee, D., Park, E.J., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Bioactive Constituents from the Aerial Parts of Antirhea acutata. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Liu, J., Burdelle, J., Xu, H., Bhat, K., Constantinou, A.I., Pezzuto, J.M., Farnsworth, N.R., and Bolton, J.L. In Vitro Estrogenic Tests of Botanicals Associated with Women’s Health. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Mi, Q., Lantvit, D., Lim, E., Chai, H., Hollingshead, M.G., Mayo, J.G., Zhao, W., Lee, I., Kinghorn, A.D., and Pezzuto, J.M. Evaluation of Therapeutic Efficacy Employing In Vivo Hollow

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Fiber Tests. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Misico, R.I., Song, L.L., Kinghorn, A.D., Pezzuto, J.M., Veleiro, A.S., Cirigliano, A., Tettamanzi, M.C., Burton, G., Bonetto, G.M., Nicotra, V.E., Silva, G.L., Gil, R.R., and Oberti, J.C. Induction of Quinone Reductase by Withanolides. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Park, E.J., Lee, D., Shin, Y.G., Lantvit, D.D., van Breemen, R.B., Kinghorn, A.D., and Pezzuto, J.M. Development of an Assay for 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A (HMG-COA) Reductase Inhibitor Based on Liquid-Chromatography-Electrospray/Mass Spectroscopy. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Peraza-Sánchez, S.R., Chai, H.-B., Shin, Y.G., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Activity Guided Fractionation of Ficus hispida. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Tamez, P.A., Gills, J.J., Tan, Y., and Pezzuto, J.M. Implementation of Macroarray Technology for Natural Product Drug Discovery and Characterization. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Tan, G.T., Pinter, A., Kayman, S.C., Honnen, W.J., and Pezzuto, J.M. A Green Fluorescent Protein-Based Reporter Cell Line for the Screening of Anti-HIV Natural Products. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Waffo-Teguo, P., Lee, D., Cuendet, M., Mérillon, J.-M., Pezzuto, J.M., and Kinghorn, A.D. Two New Stilbene Dimer Glucosides from Vitis vinifera Cell Cultures. 41st Annual Meeting of the American Association of Pharmacognosy, Seattle, Washington, July 22-26, 2000.

Pezzuto, J.M., Tamez, P., Do, T.T., and Tan, G.T. Infectious Disease Assays at UIC. ICBG Network Meeting, NIH Campus, Bethesda, MD, July 31-August 2, 2000.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Grand Rounds presentation at Ohio State University Cancer Center, Columbus, OH, September 6, 2000.

Blatt, C.T.T., Chávez, D., Chai, H., Graham, J.G., Cabieses, F., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Activity-Guided Isolation of Cytotoxic Constituents of Muellera denudata Bark. 22nd International Symposium on Natural Products Chemistry (IUPAC), Sâo Carlos, Brazil, September 4-8, 2000.

Pezzuto, J.M. Experimental Paradigm for the Discovery of Novel Natural Product Cancer Chemopreventive Agents. 7th ICMAA Meeting, Grand Rapids, MI, September 23-27, 2000.

Pezzuto, J.M. Cancer Chemoprevention with Phytonutrients: A Possible Sleeping Giant. Symposium on Advances in Clinical Nutrition: The American College of Nutrition 41st Annual Meeting, Las Vegas, NV, October 12-15, 2000.

Bhat, K.P., Cuendet, M., and Pezzuto, J.M. Anti-Inflammatory Modes of Action of Plant Phenols. Plant and Animal Genome XI. San Diego, CA, January 13-17, 2001.

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Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Department of Pharmaceutics and Pharmacodynamics, UIC, January 24, 2001.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreven-tive Agents. University of Kentucky, Lexington, KY, March 8, 2001.

Bhat, K.P.L., Lanvit, D., Christov, K., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Characterization of estrogen modulatory effects of resveratrol in normal, preneoplastic, and neoplastic mammary tissue. Proc. Am. Assoc. Cancer Res. 42: 19, 2001.

Constantinou, A.I., Xu, H. Cunningham, E., Lanvit, D.D., and Pezzuto, J.M. Consumption of soy products may enhance the breast cancer-preventive effects of tamoxifen. Proc. Am. Assoc. Cancer Res. 42: 826, 2001.

Cuendet, M. and Pezzuto, J.M. Mechanism of brusatol-induced HL-60 cell differentiation. Proc. Am. Assoc. Cancer Res. 42: 186, 2001.

Deflora, S., Izzotti, A., Camoirano, A., Cartiglia, C., Pezzuto, J.M., Grubbs, C.J., and Lubet, R.A. Efficacy of phase I/II and "pure" phase II inducers in blocking dimethylbenzanthracene (DMBA) related DNA adducts: effects of inhibitor dose and dose of DMBA. Proc. Am. Assoc. Cancer Res. 42: 866, 2001.

Murillo, G., Salti, G.I., Starr, F.L., Kosmeder, J., Pezzuto, J.M., and Mehta, R.G. Induction of apoptosis in colon cancer cells by deguelin. Proc. Am. Assoc. Cancer Res. 42: 449, 2001.

Primiano, T., Chang, B.-D., Kosmeder, J.W., Pezzuto, J.M., and Roninson, I.B. Inhibition of cell proliferation in prostate carcinoma cells by the chemopreventive rotenoid deguelin. Proc. Am. Assoc. Cancer Res. 42: 869, 2001.

Starr, F.L., Kosmeder, J., Murillo, G., Pezzuto, J., Das Gupta, T.K., and Mehta, R. Deguelin induces G1 arrest in human melanoma cells through down regulation of E2F-1. Proc. Am. Assoc. Cancer Res. 42: 912, 2001.

Bhat, K.P.L. and Pezzuto, J.M. Cancer Chemopreventive Activity of Resveratrol. Alcohol and Wine in Health and Disease Conference, Palo Alto, CA, April 26-29, 2001.

Pezzuto, J.M. Discovery of Natural Plant Anticarcinogens of Relevance to Human Health. Collaborative Research Programs in Organic Synthesis and Bioactive Natural Products. Mahidol University, Bangkok, Thailand, May 15, 2001.

Sujarit, K., Pootrakronchai, R., Sundararjun, P., Suksen, K., Pompimon, W., Tuchinda, P., Sophasan, S., Reutrakul, V., Upatham, S., and Pezzuto, J.M. Cytotoxicity and Mechanisms of VR-3623 and VR-3848-Induced Apoptotic Cell Death. Mahidol University, Bangkok, Thailand, May 15, 2001.

Tuchinda, P., Pohmakotr, M., Reutrakul, V., Munyoo, B., Thanyachareon, W., Sophasan, S., Yoosook, C., Thinapong, P., Rangsiman, O., Santisuk, T., and Pezzuto, J.M. Bioactive Compounds from Plants in Genus Polyalthia. Mahidol University, Bangkok, Thailand, May 15, 2001.

Pezzuto, J.M. Infectious Disease Assays at UIC. Biological Evaluation of Plants, Conservation of Resources, and Economic Development. UIC-Based Vietnam-Laos ICBG Annual

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Meeting. Traditional Medicine Research Center, Vientiane, Laos, May 18, 2001.

Pezzuto, J.M. Discovery of Natural Plant Anticarcinogens of Relevance to Human Health. “Natural Products Drug Discovery in the Framework of the Convention on Biological Diversity (CBD) in Indonesia” and Launching of BIMAPS Webb and BICHEMS Webb Services. Jakarta, Indonesia, May 21, 2001.

Shin, Y.G., Kosmeder, J.W., Song, L., Pezzuto, J.M., and van Breemen, R.B. Identification of Photo-degradation Products of Brassinin with Quinone Reductase Induction Activity by LC-DAD-MS and LC-MS-MS. 49th American Society for Mass Spectrometry Meeting, Chicago, IL, May 27-31, 2001.

Shin, Y.G., Yu, C., Li, Y., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B. Human and Rat Metabolism of the Botanical Natural Product Resveratrol Determined Using LC-DAD-MS and LC-MS-MS. 49th American Society for Mass Spectrometry Meeting, Chicago, IL, May 27-31, 2001.

Constantinou, A.I., Lantvit, D., Xu, X., van Breemen, R.B., Nho, C.W., Jeffery, E.H., and Pezzuto, J.M. Soy with Low Isoflavone Levels is a More Effective Inhibitor of Mammary Carcinogenesis in Female Sprague-Dawley Rats than Soy with High Isoflavone Levels. International Institute of Anticancer Research. 2001 International Conferences, Athens, Greece, May 25-June 17, 2001, Anticancer Res. 21 (3A): 1559, 2001.

Constantinou, A.I., Swanson, S., Yang, Y., Salti, G.I, and van Breemen, R. The Effect of Lycopene on N-methyl-n-nitrosourea Induced DNA Damage in the Rat Lymphocytes and Prostate Tissue. International Institute of Anticancer Research. 2001 International Conferences, Athens, Greece, May 25-June 17, 2001, Anticancer Res. 21 (3A): 1560, 2001.

Pezzuto, J.M. Discovery of Natural Plant Anticarcinogens of Relevance to Human Health. European Conference on Nutrition & Cancer, Lyon, France, June 21-24, 2001.

Pezzuto, J.M. Activity-Guided Isolation of Natural Product Cancer Chemopreventive Agents. 11th Annual Research Conference on Diet, Nutrition and Cancer, Washington, DC, July 16-17, 2001.

Chávez, D., Cui, B., Chai, H.-B., García, R., Mejía, M., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Multi-Drug Resistance Inhibitory Tropane Alkaloids from the Stems of Erythroxylum rotundifolium. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Cui, B., Silva, G., Chávez, Mi, Q., You, M., Chai, H.-B., Rasoanaivo, P., Lynn, S.M., On’Neill, M.J., Lewis, J.A., Besterman, J.M., Monks, A., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Modulation of the Multidrug-Resistance Phenotype by Novel Tropane Alkaloid Esters from Erythroxylum pervilleii. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Gu, J.-Q., Gills, J.J., Park, E.J., Hawthorne, M.E., Axelrod, F., Chavez, P.I., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Sesquiterpenoids from Tithonia diversifolia with Potential Cancer Chemopreventive Activity. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Ito, A., Chai, H.-B., Lee, D., Kardono, L.B.S., Riswan, S., Farsnworth, N.R., Cordell, G., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic Constituents of Elaeocarpus mastersii. 42nd Annual

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Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Lee, D., Cuendet, M., Cabieses, F., Vigo, J.S., Fong, H.H.S, Pezzuto, J.M., and Kinghorn, A.D. A Novel Cyclooxygenase-Inhibitory Stilbenolignan from the Seeds of Aiphanes aculeata. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Lee, D., Cuendet, M., Axelrod, F., Chavez, P.E., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Novel 29-Nor-3,4-Seco-Cycloartane Triterpene Methyl Esters from the Aerial Parts of Antirhea acutata. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Su, B.-N., Misico, R., Park, E.J., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. New Constituents of the Leaves and Stems of Physalis philadelphica (Tomatillos) with Potential Cancer Chemopreventive Activity. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Su, B.-N., Cuendet, M. Kardono, L.B.S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the Bark and Twigs of Artocarpus dadah with Cyclooxygenase Inhibitory Activity. 42nd Annual Meeting of the American Association of Pharmacognosy, Oaxaca, Mexico, July 14-18, 2001.

Soejarto, D.D., Pezzuto, J.M., Fong, H.H.S., Tan, G.T., Franzblau, S.G., Gyllenhaal, C., Regalado, J.C., Hiep, N.T., Xuan, L.T., Hung, N.V., Bich, T.Q., Loc, P.K., Vu, B.M., Southavong, B.H., Sydara, K., Bouamanivong, S., O'Neill, M.J., and Dietzman, G. Busqueda de Compuestos Bioactivos. First Symposium on Biodiversity as a Source of New Medicines, 8th Congress of Pharmacology, Cali, Colombia, August 16-19, 2001

Su, B.-N., Chang, L.C., Park, E.J., Cuendet, M., Santarsiero, B.D., Mesecar, A.D., Mehta, R.G., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Bioactive Constituents of the Seeds of Brucea javanica. 222nd National Meeting of the American Chemical Society. Chicago, IL, August 26-30, 2001.

Burdette, J.E., Liu, J., Chadwick, L., Sun, Y.K., van Breemen, R.B., Pezzuto, J.M., Farnsworth, N.R. and Bolton, J.L. Evaluation of Humulus lupulus extracts for estrogenic properties. 222nd National Meeting of the American Chemical Society. Chicago, IL; August 26-30, 2001.

Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Recent Studies in Natural Product Chemistry. Indonesia, October 2001.

Pezzuto, J.M. Importance of Bioassays for the Discovery of Anti-HIV, Anticancer and Antimalaria Drugs. Congress of the Pharmaceutical Federation of South America, Caracas, Venezuela, November 27-December 1, 2001.

Pezzuto, J.M. Cancer Chemoprevention. Faculty of Pharmacy, University of Central Venezuela, Cararcas, Venezuela, November 29, 2001.

Pezzuto, J.M. Discovery and Characterization of Cancer Chemopreventive Agents. College of Pharmacy, University of Minnesota, Minneapolis, MN, December 11, 2001.

Murillo, G., Hirschelman, W.H., Kosmeder, J.W., Moriarty, R.M., Pezzuto, J.M., and Mehta, R.G. Zapotin, a novel chemopreventive agent inhibits Azoxymethane-induced aberrant crypt formation in CF-1 mice. Proc. Am. Assoc. Cancer Res. 43: 125, 2002.

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Cuendet, M., Mi, Q., Park, E.J., Mata-Greenwood, E., and Pezzuto, J.M. Mechanism of brusatol- and bruceantin-induced cell differentiation in a variety of leukemia cell lines. Proc. Am. Assoc. Cancer Res. 43: 255, 2002.

Tan, Y., Yu, R., and Pezzuto, J.M. Signaling mechanisms involved in betulinic acid-induced apoptosis in melanoma cells. Proc. Am. Assoc. Cancer Res. 43: 409, 2002.

Froix, A.J., Murillo, G., Kosmeder, J.W., Pezzuto, J.M., Boddie Jr., A.W., Das Gupta, T.K., and Mehta, R.G. Combination chemotherapeutic efficacy of dacarbazine and deguelin in melanoma cells. Proc. Am. Assoc. Cancer Res. 43: 947, 2002.

Park, E.J. and Pezzuto, J.M. Discovery of Biologically Active Phenolic Substances. Plant Phenolics and Health Research Interest Group, FASEB, New Orleans, LA, April 20, 2002 (Keynote Address).

Yu, C., Shin, Y.G., Pezzuto, J.M., and van Breemen, R.B. Characterization of UDP-glucuronosyltransferases and sulfotransferases responsible for in vivo metabolism of resveratrol by using LC-DAD-MS and LC-UV-MS-MS. 50th ASMS Conference on Mass Spectrometry and Allied Topics. Orlando, FL; June 2-6, 2002.

Pezzuto, J.P., Yu, C., and van Breemen, R.B. Metabolism of resveratrol. 26 th

International Symposium on High Performance Liquid Phase Separations and Related Techniques. Montreal, Canada. June 2-7, 2002.

Koch, A., Tamez, P., Mathenge, S., Pezzuto, J.M., and Soejarto, D.D. Evaluation of anti-malarial plant remedies used by the Maasai of Kenya. 43rd Annual Meeting of the Society for Economic Botany, The New York Botanical Garden, June 22-27, 2002.

Cuendet, M., Lantvit, D.D., McChesney, J.D., Helson, L., and Pezzuto, J.M. Antitumor activity of bruceantin: An old drug with new promise. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Zhang, H.J., Tan, G.T., Hoang, V.D., Hung, N.V., Cuong, N.M., Thao, D.T., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Natural anti-HIV constituents from Litsea verticillata. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Su, B.-N., Park, E.J., Vigo, J.S., Graham, J.G., Cabieses, F., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation and cancer chemopreventive potential of unusual C-18 norwithanolides with a new type of carbon skeleton from Solanum altissimum. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Gu, J.-Q., Park, E.J., Vigo, J.S., Graham, J.G., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme, quinone reductase. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Zhang, H.-J., Tan G.T., Hoang, V.D., Hung, N.V., Cuong, N.M., Thao, D.T., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Natural anti-HIV constituents from Vatica cinerea. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

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Mi, Q., Lantivit, D., Lim, E., Chai, H., Zhao, W., Lee, I.-S., Peraza-Sánchez, S., Ngassapa, O., Kardono, L.B.S., Riswan, S., Hollingshead, M.G., Mayo, J.G., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Diaz, F., Chavez, D., Mi, Q., Chai, H.-B., Tan, G.T., Kardono, L.B.S., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic flavonone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Hwang, B.Y., Chai, H.-B., Kardono, L.B.S., Riswan, S., Farnsworth, N.R., Cordell, G.A. Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic triterpenes from the twigs of Celtis philippinensis. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Gu, J.-Q., Park, E.J., Totura, S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Jang, D.S., Cuendet, M., Hawthorne, M.E., Kawanishi, K., Kardono, L.B.S., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Prenylated flavonoids of the leaves of Macaranga conifera with cyclooxygenase (COX-2) inhibitory activity. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Jang, D.S., Park, E.J., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Musa sapientum (banana) with the potential to induce the phase II enzyme, quinone reductase. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Su, B.-N., Park, E.J., Mbwambo, Z.H., Santarsiero, B.D., Mesecar, A.D., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a Mosher ester procedure conveniently carried out in a NMR tube. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Zhang, H.-J., Tamez, P.A., Hashimoto, K., Nakata, M., Aydogmus, Z., Tan, G.T., Hung, N.V., Xuan, L.T., Cuong, N.M., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Isolation of potent antimalarial trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Park, E.J., Tan, Y., Su, B., Yu, R., Kosmeder II, J.W., Kinghorn, A.D., and Pezzuto, J.M. Development of high throughput screening assays for inducers of the antioxidant and xenobiotic response elements. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Seo, E.-K., Kim, N.-C., Mi, Q., Chai, H., Navarro, H.A., Burgess, J.P., Mukherjee, R., Tan, G.T., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., Wani, M.C., and Wall, M.E. New benzophenone and phloroglucinol derivatives from Rheedia brasiliensis. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

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Chen, S.-N., Burdette, J.E., Xu, H.-Y., Lu, Z.-Z., Zhang, H., Fabricant, D.S., Constantinou, A.I., Bolton, J.L., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Cimicifugates A-D, novel dilignan phenolic acid esters from the rhizomes of Cimicifuga racemosa. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Chadwick, L.R., Chen, S.-N., Burdette, J.E., Bolton, J.L., Pezzuto, J.M., Nikolic, D., Sun, Y., van Breemen, R.B., Fong, H.H.S., and Farnsworth, N.R. Chemical and pharmacological standardization of hops. Part I: Isolation and charaterization of estrogenic constituents. 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Plocher, J., Best, K., Cuendet, M., Chai, K.-H., Kang, Y.H., Park, E.J., Gills, J., Pezzuto, J., Knight, C., Smith, M.A.L., and Seigler, D.S. Bioactive components from purple chokeberry (Aronia prunifolia) and American elderberry (Sambucus Canadensis). 43rd Annual Meeting of the American Association of Pharmacognosy, New Brunswick, New Jersey, July 27-31, 2002.

Kosmeder II, J.W., Hirschelman, W.H., Song, L.S., Park, E.J., Tan, Y., Yu, R., Hawthorne, M., Mehta, R.G., Grubbs, C.J., Lubet, R.A., Moriarty, R.M., and Pezzuto, J.M. Cancer chemopreventive activity of oxomate, a monofunctional inducer of Phase II detoxification enzymes. 224th American Chemical Society National Meeting, Boston, Massachusetts, August 18-22, 2002.

Hirschelman, W.H., Kosmeder II, J.W., Song, L.S., Park, E.J., Moriarty, R.M., and Pezzuto, J.M. Design and lead optimization of oxomate, a novel phase II enzyme inducer. 224th American Chemical Society National Meeting, Boston, Massachusetts, August 18-22, 2002.

Pezzuto, J.M. Discovery and characterization of novel natural cancer chemopreventive agents. 224th American Chemical Society National Meeting, Boston, Massachusetts, August 18-22, 2002.

Pezzuto, J.M. Discovery and characterization of novel natural cancer chemopreventive agents. American Association for Cancer Research Frontiers in Cancer Prevention Research Meeting, Boston, Massachusetts, October 14-18, 2002.

Kang, Y.-H., Gu, J., Tan, Y., Yu, R., Kinghorn, A.D., and Pezzuto, JM. Induction of antioxidant response element by withanolides isolated from Physalis philadelphica American Association for Cancer Research Frontiers in Cancer Prevention Research Meeting, Boston, Massachusetts, October 14-18, 2002.

Yu, C., Shin, Y.G., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B. Assessment of human CYP inhibition by resveratrol and resveratrol-3-sulfate by using LC-MS-MS. 11th North American ISSX Meeting. Orlando, FL; October 27-31, 2002.

Pezzuto, J.M. Invited Speaker, “Discovery and Characterization of Natural Product Cancer Chemoprevention Agents”, Spring Corporate Affiliates Meeting, Botanicals Center for Age Related Diseases with an Emphasis on Polyphenols, 2003 Purdue-UAB Symposium, Department of Foods and Nutrition, Purdue University, February 28, 2003.

Pezzuto, J.M. Invited Speaker, “Novel Pharmacological Targets for Medicinal Plant Research”, International Symposium of the Society for Medicinal Plant Research, Bad Camberg/Taunus, Germany, April 8, 2003.

Tan, Y. and Pezzuto, J.M. Mitochondrial Events in Programmed Cell Death Modulated by Betulinic Acid in Human Melanoma Cells. Proc. Am. Assoc. Cancer Res. 44: 146, 2003.

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Gills, J.J., Jeffery, E.H., Moon, R.C., Lantvit, D.D., and Pezzuto, J.M. Effects of Sulforaphane on UVB-Induced Skin Carcinogenesis. Am. Assoc. Cancer Res. 44: 223, 2003.

Cuendet, M., Ojima, I., and Pezzuto, J.M. Mechanism of the Second-Generation Taxoid-Induced Apoptosis in KB Cells. Am. Assoc. Cancer Res. 44: 606, 2003.

Cuendet, M., Christov, K.T., Lantvit, D.D., McChesney, J.D., and Pezzuto, J.M. Bruceantin-Induced Apoptosis In Vitro and In Vivo in a Multiple Myeloma Model. Am. Assoc. Cancer Res. 44: 1057, 2003.

Choi, J.K., Pawlus, A.D., Su, B.-N., Jang, D.S., Murillo, G., Pezzuto, J.M., Kinghorn, A.D., and Mehta, R.G. Efficacy of Potential Chemopreventive Agents of Plant Origin in Colon Carcinogenesis. Am. Assoc. Cancer Res. 44: 1097, 2003.

Burdette, J.E., Liu, J., Piersen, C., Chen, S.-N., Lu, Z.-Z., Fabricant, D.S., Barker, E., Pezzuto, J., Farnsworth, N.R., and Bolton, J.L. Cimicifuga racemosa as a Serotonin Receptor Agonist: A Potential Mechanism for the Treatment of Menopausal Hot Flashes Without Estrogenic Effects. Am. Assoc. Cancer Res. 44: 1506, 2003.

Li, Y., Shin, Y.G., Yu, C., Kosmeder, J.W., Hirschelman, W.H., Pezzuto, J.M., and van Breemen, R.B. Transport and metabolism of resveratrol in human intestinal Caco-2 cells. 51st

ASMS Conference on Mass Spectrometry and Allied Topics. Montreal, Canada; June 8-12, 2003.

Yu, C., Lyons, M., Cho, S.Y., Toma, R., Pezzuto, J.M., and van Breemen, R.B. Quantitative analysis of resveratrol in raw and baked blueberries and bilberries. 51st ASMS Conference on Mass Spectrometry and Allied Topics. Montreal, Canada; June 8-12, 2003.

Li, Y., Hirschelman, W.H., Shin, Y.G., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B. In vitro studies of the metabolism and intestinal absorption of oxomate and sulforamate – two promising cancer chemopreventive agents. Functional Foods for Health 12 th

Annual Conference, Schaumburg, IL; July 9-11, 2003.

Carcache-Blanco, E.J., Kang, Y.H., Park, E.J., Su, B-N., Kardono, L.B.S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the Stem Bark of Pongamia pinnata with the Potential to Induce Quinone Reductase. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Jang, D.S., Cuendet, M., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of Asparagus officinalis (Asparagus) with Inhibitory Activity Against Cyclooxygenase-2. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Su, B.-N., Kang, Y.-H., Pinos, R.E., Santarsiero, B.D., Mesecar, A.D., Soejarto, D.D., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Isolation and Absolute Stereochemistry of Coussaric Acid, a New Bioactive Triterpenoid from the Stems of Coussarea brevicaulis. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Su, B.-N., Cuendet, M., Kardono, L.B.S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Constituents of the Stems of Macrococculus pomiferus and the Evaluation of their Inhibitory Activity Against Both Cyclooxygenases-1 and 2. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

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Pawlus, A.D, Choi, J.K., Chai, K.H, Kang, Y.H., Farnsworth, N.R., Pezzuto, J.M., Mehta, R.G., and Kinghorn, A.D. Potential Cancer Chemopreventive Agents from Aglaia ponapensis. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Jang, D.S., Park, E.J., Kang, Y.H., Choi, J.K., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., and Kinghorn, A.D. Flavonoids from the Stems of Tephrosia toxicaria with the Potential to Induce the Phase II Enzyme, Quinone Reductase. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Diaz, F., Chai, H.-B., Su, B.-N, Vigo, J.S., Graham, J.G., Cabieses, F., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Anthaquinones from Two Different Plant Parts of Picramnia latifolia. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Mi, Q., Cui, B., Lantvit, D., Reyes-Lim, E., Chai, H., Hollingshead, M.G., Mayo, J.G., Pezzuto, J.M., Kinghorn, A.D., and Swanson, S.M. Pervilleine F, a New Tropane Alkaloid Aromatic Ester that Reverses Multidrug-Resistance. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Lobo-Echeverri, T., Chai, H.-B., Rivero-Cruz, J.F., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Kinghorn, A.D., and Soejarto, D.D. Biodiversity-Based Plot Inventory in the Search for Anticancer Leads. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Ito, A., Chai, H.-B., Kardono, L.B.S., Riswan, S., Farnsworth, N.R., Cordell, G., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Saponins from the Bark of Nephelium mangayi. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Rivero-Cruz, J.F., Chai, H.-B., Kardono, L.B.S., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Cytotoxic Constituents of the Twigs and Leaves of Aglaia rubiginosa. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Gu, J.-Q., Graf, T.N., Lee, D., Chai, H.-B., Mi, Q., Kardono, L.B.S., Setyowati, F.M., Ismail, R., Riswan, S., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Kroll, D.J., Falkinham III, J.O., Wall, M.E., Wani, m.C., Kinghorn, A.D., and Oberlies, N.H. Variations in the cytotoxic and antimicrobial constituents of the bark of Diospyros maritime collected in two geographical locations in Indonesia. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

He, Z.-D., Ma, C.-Y., Sydara, K., Bouamanivong, S., Zhang, H.-J., Tan, G.T., Tamez, P., Southavong, B., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. New antimalarial compounds from Rourea minor. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Zhang, H.-J., Sydara, K., Tan, G.T., Southavong, B., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Bioactive constituents from Asparagus cochinchinensis. 44th Annual Meeting of the American Association of Pharmacognosy, Chapel Hill, North Carolina, July 12-16, 2003.

Grubjesic, S., Li, Y., Kosmeder, J.W., van Breemen, R.B., Pezzuto, J.M., and Moriarty, R.M. Syntheses and structure verification of 4-bromoflavone metabolites. 226th ACS National

130

Meeting, New York, NY; September 10, 2003.

Li, Y., Hirschelman, W.H., Shin, Y.G., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B. In vitro studies of the metabolism and intestinal absorption of the cancer chemoprevention agents oxomate and sulforamate. 12th North American ISSX Meeting, Providence, RI; October 12-16, 2003. Published in Drug Metab. Rev. 2003, 35 (suppl. 2): 147.

Cuendet, M., Pezzuto, J.M., and Ojima, I. Induction of apoptosis by second-generation taxoids through a caspase-3 independent/caspase-9 dependent pathway in KB cells. AACR-NCI-EORTC 2003, Boston, Massachusetts, November 17-21, 2003.

Pezzuto, J.M. Natural Product Inhibitors of Carcinogenesis. University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Pharmacology Seminar Series, Piscataway, New Jersey, March 4, 2004.

Pezzuto, J.M. Natural Inhibitors of Carcinogenesis. Cancer Prevention Seminar, National Cancer Institute, Rockville, Maryland, May 19, 2004.

Hwang, B.Y., Su, B.-N., Kim, S., Chai, H., Mi, Q., Kardono, L.B.S., Afriastini, J.J., Riswan, S., Santarsiero, B.D., Mesecar, A.D., Wild, R., Fairchild, C.R., Vite, G.D., Rose, W.C., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Structure and stereochemistry of the rocaglate derivative, silvestrol, a constituents of Aglaia silvestris with antineoplastic activity. 2004-International Congress on Natural Products Research, Phoenix, Arizona, July 31-August 4, 2004.

Jang, D.S., Su, B.-N., Pawlus, A.D., Jones, W.P., Kleps, R.A., Santisuk, T., Reutrakul, V., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Limnophilaspiroketone, a highly oxygenated structure novel phenolic derivative from Limnophila geoffrayi. 2004-International Congress on Natural Products Research, Phoenix, Arizona, July 31-August 4, 2004.

Jones, W.P., Lobo-Echeverri, T., Chai, H., Mi, Q., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., and Kinghorn, A.D. Cytotoxic constituents from Avicennia germinans. 2004-International Congress on Natural Products Research, Phoenix, Arizona, July 31-August 4, 2004.

Mi, Q., Lantvit, D., Reyes-Lim, E., Chai, H., Phifer, S.S., Wani, M.C., Wall, M.E., Tan, G.T., Cordell, G.A., Farnsworth, N.R., Kinghorn, A.D., and Pezzuto, J.M. Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis. 2004-International Congress on Natural Products Research, Phoenix, Arizona, July 31-August 4, 2004.

Eggler, A.L., Liu, G., Pezzuto, J.M., van Breemen, R.B., and Mesecar, A.D. Alkylating specific cysteines of the human electrophile-sensing protein Keap1 does not disrupt the tight association with the Nrf2 domain Neh2. 96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA; April 16-20, 2005.

Zhu, D., Liu, A., Guo, J., Pang, Y., Wang, Y., Liang, W., Nikolic, D., Pezzuto, J.M., and van Breemen, R.B. In vitro assessment of intestinal permeability and inhibition of human cytochrome P450 isozymes by isoliquiritigenin. 53rd ASMS Conference on Mass Spectrometry and Allied Topics. San Antonio, TX; June 5-9, 2005.

Pezzuto, J.M. Discovery and Characterization of Natural Product Cancer Chemopreventive Agents. Indiana University Cancer Center, Indianapolis, Indiana, June 15, 2005.

Pezzuto, J.M. Molecular Targeting by Natural Preventive Agents. Keystone Symposia,

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Molecular Targets for Cancer Prevention, Tahoe City, California, March 7, 2006.

Guo, J., Pezzuto, J.M., and van Breemen, R.B. Quantitative analysis of the chemoprevention agent isoliquiritigenin in rat plasma using liquid chromatography-tandem mass spectrometry. 54th ASMS Conference on Mass Spectrometry and Allied Topics. Seattle, WA; May 28-June 1, 2006.

Pang, Y., Pezzuto, J.M., and van Breemen, R.B. In vitro metabolism of abyssinone II, a potent anticancer agent from Broussonetia papyrifera (L.). 54th ASMS Conference on Mass Spectrometry and Allied Topics. Seattle, WA; May 28-June 1, 2006.

Pezzuto, J.M., Fenical, W., Cushman, M., Chang, C.-j., Craig, B., Moon, R., Mesecar, A., van Breemen, R.B., and Fong, H.H.S. Discovery of Natural Products as Inhibitors of Carcinogenesis. 47th Annual Meeting of the American Association of Pharmacognosy, Arlington, Virginia, August 5-9, 2006.

Ma, Z., Croy, V.L., Kondratyuk, T., Cuendet, M., Caceres, A., Fong, H.H.S., Pezzuto, J.M., and Chang, C.-j. Bioactive Constituents from Sambucus mexicana. 47th Annual Meeting of the American Association of Pharmacognosy, Arlington, Virginia, August 5-9, 2006.

Zhang, H., Homhual, S., Jutiviboonsuk, A., Kondratyuk, T.P., Herunsalee, A., Chaukul, W., Pezzuto, J.M., Fong, H.H.S., and Bunyapraphatsara, N. Cancer Chemopreventive Triterpenes from Brugueria gymnorrhiza and Barringtonia maunwongyathiae. 47th Annual Meeting of the American Association of Pharmacognosy, Arlington, Virginia, August 5-9, 2006.

Endringer, D.C., Kondrayuk, T.P., Braga, F.C., and Pezzuto, J.M. Phytochemical Study of Hancornia speciosa Guided by In Vitro Cancer Chemopreventive Assays. 47th Annual Meeting of the American Association of Pharmacognosy, Arlington, Virginia, August 5-9, 2006.

Balunas, M.J., Jones, W.P., Chin, Y.-W., Mi, Q., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Swanson, S.M., Pezzuto, J.M., Chai, H.-B., and Kinghorn, A.D. Relationships Between Cytotoxicity, Plant Profiles, and Compound Classes Isolated in an Anticancer Drug Discovery Project. 47th Annual Meeting of the American Association of Pharmacognosy, Arlington, Virginia, August 5-9, 2006.

Maiti, A., Pezzuto, J.M., Cuendet, M., Kondratyuk, T., Croy, V.L., and Cushman, M. Multi-gram total syntheses of aapotin and (±)-abyssinone II, cancer chemopreventive natural products. 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006.

Chair, Workshop 1, Keystone Symposia, Molecular Targets for Cancer Prevention, Tahoe City, California, March 6-8, 2006.

Mesecar, A.D., Eggler, A.L., Calamini, B., van Breemen, R.B., and Pezzuto JM. Natural products and their pleiotropic interactions with molecular targets: towards the molecular basis for cancer chemoprevention. 223rd American Chemical Society National Meeting. Chicago, IL. March 25-29, 2007.

Guo, J., Liu, A., Pezzuto, J.M., and van Breemen, R.B. Identification of GSH conjugates of isoliquiritigenin, a chemoprevention agent, in human hepatocytes and rat liver using liquid chromatography-tandem mass spectrometry. 55th ASMS Conference on Mass Spectrometry and Allied Topics. Indianapolis, IN; June 3-7, 2007.

Pezzuto, J.M. Invited lecture, Natural Inhibitors of Carcinogeneis, 13 th Anniversary of the Korea Institute of Oriental Medicine, Daejeon, Korea, September 18, 2007.

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Pezzuto, J.M. Invited lecture, Natural Inhibitors of Carcinogenesis, Forest Service, Department of Agriculture, Natural History and Conservation Hilo Seminar Series 2007-2008, Hilo, Hawaii, November 6, 2007.

Pezzuto, J.M. Invited lecture, Isolation and Evaluation of Natural Product Cancer Chemopreventive Agents, American Association for Cancer Research 2007 Frontiers in Cancer Prevention Research Conference, Philadelphia, Pennsylvania, December 5-8, 2007.

Pezzuto, J.M. Invited lecture. Cancer Chemoprevention, Cancer Research Center of Hawaii, Honolulu, HI, April 10, 2008.

Ghufran, M.A., Qureshi, R.A., Batool, A., Kondratyuk, T.P., Guilford, J., Marler, L., Chang, L.C., and Pezzuto, J.M. Evaluation of Indigenous Medicinal Plants from Western Himalayas as Potential Cancer Chemopreventive Agents. Proceedings of 31st Annual Conference of Society of Ethnobiology, April 13-16, 2008, Fayetteville, Arkansas.

Li, J., Cushman, M., Pezzuto, J.M., and van Breemen, R.B. In vitro metabolism of zapotin from Casimiroa edulis in human liver microsomes and cryopreserved human hepatocytes. 56th ASMS Conference on Mass Spectrometry and Allied Topics, Colorado Convention Center, Denver, Colorado, June 1-5, 2008.

Choi, Y., Mesecar, A.D., Sturdy, M., Pezzuto, J.M., and van Breemen, R.B. Screening natural products for ligands to quinone reductase-2 using ultrafiltration LC-MS. 56 th ASMS Conference on Mass Spectrometry. Denver, CO; June 1-5, 2008.

Kondratyuk, T.P., Marler,L.E., Guilford, J., Maloney,K., Fenical, W., and Pezzuto J.M. The marine environment as a resource for discovery of chemopreventive agents. Proceedings of AAAS Pacific Division 89th Annual Meeting, June 15-20, 2008, Waimea, HI.

Pezzuto, J.M. Invited lecture. Discovery of Natural Inhibitors of Carcinogenesis, Phytochemical Society of North America, Pullman, WA, June 25-28, 2008.

Pezzuto, J.M., Chang, C.J., Craig, B.A., Cushman, M.S., Fenical, W., Fong, H.H.S., Mesecar, A., Moon, R.C., and van Breemen, R.B. Natural product cancer chemoprevention agents. Annual Meeting of the Phytochemical Society of North America. Pullman, WA ; June 28-30, 2008.

Yao, G.M., Kondratyuk, T., Pezzuto, J.M., and Chang, L.C. Bioactive Sulfated Sesterterpene Alkaloids from the Marine Sponge Fasciospongia sp. International Pharmacognosy Meeting and 49th Annual American Society of Pharmacognosy Meeting, Athens, Greece, August 3-8, 2008.

Pezzuto, J.M. Presentation at Rotary Club of Kona Mauka, October 14, 2008.

Pezzuto, J.M. Medical Service Representatives of Hawaii (MSRH), November 3, 2008, Honolulu, Hawaii.

Pezzuto, J.M. and Morris, K.R. Influence of Mother Nature’s Pharmacopeia on Everyday Health and Wellbeing. Frontiers in Cancer Prevention Research. Seventh Annual AACR International Conference. Washington, D.C. November 16-19, 2008 (Plenary Session).

Pezzuto, J.M. National Grape and Wine Initiative (NGWI) Grape Health Workshop, San Francisco, California, December 2-3, 2008 (Moderator and Speaker).

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Pezzuto, J.M. Soliciting Nature’s help for the prevention of cancer. Hecht Symposium, University of Virginia, Charlottesville, VA, April 3-4, 2009.

Maloney, K., Nam,S.J., Fukuda, T., Gaudencio, S., MacMillan, J.B., Sturdy, M., Mesecar, A., Choi, Y., van Breemen, R., Fenical, W., and Pezzuto, J. X-ray crystallography- and mass spectrometry-based screens of natural product mixtures reveal potent and structurally novel quinone reductase 2 inhibitors from marine sediment bacteria. AACR 100th Annual Meeting 2009, Denver, Colorado, April 18-22, 2009.

Ahn, S.; Cushman, M.D.; Pezzuto, J.M.; van Breemen, R.B. Studies of intestinal absorption and serum levels of novel chemopreventive agents. 57th ASMS Conference on Mass Spectrometry Meeting, Philadelphia, Pennsylvania, May 31 to June 4, 2009.

Choi, Y., Sturdy, M., Maloney, K., Nam, S.J., Mesecar, A.D., Pezzuto, J.M., Fenical, W.; Orjala, J., and van Breemen, R.B. Determination of relative affinities of staurosporine derivatives for quinone reductase-2 using ultrafiltration of LC-MS. 57th ASMS Conference on Mass Spectrometry Meeting, Philadelphia, Pennsylvania, May 31 to June 4, 2009.

Deng, Y., Balunas, M.J., Kim, J-A, Lantvit, D.D., Chin, Y-W, Chai, H., Sugiarto, S., Kardono, L.B.S., Fong, H.H.S., Pezzuto, J.M., Swanson, S.M., Carcache de Blanco, E.J., and Kinghorn, A.D. Bioactive 5,6-dihydropyrone derivatives from Hyptis brevipes. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Luqman, S., Morais, M.C.C., Kondratyuk, T.P., Petronio, M.S., Regasini, L.O., Silva, D.H.S., Bolzani, V.S., Soares, C.P., and Pezzuto, J.M. Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic alkyl-gallates: Possible role in cancer chemoprevention. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Kondratyuk, T.P., Park, E-J, Pezzuto, J.M., Asolkar, R., Maloney, K.N., and Fenical, W. Novel NFκB inhibitors from marine actinomycetes targeting apoptosis in human leukemia HL-60 cells. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Cheng, Y., Yang, J., Kondratyuk, T.P., Qiu, X., Choi, Y., Liu, Y., Wang, L., Mesecar, A.D., van Breemen, R.B., Pezzuto, J.M., Fong, H.H.S., and Zhang, H. New cancer chemopreventive kaempferol glycosides from Neocheiropteris palmatopedata. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Schupp, P., Kohlert-Schupp, C., Pezzuto, J.M., Kondratyuk, T., Park, E-J, Marler, L., and Wright, A.D. Chemoprotective and anticancer screening of extracts from marine macro- and micro-organisms sampled from waters around Guam. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Kondratyuk, T.P., Park, E-J, Marler, L., Rostama, B., Pezzuto, J.M., and Cushman, M. Mechanism-based screening of resveratrol derivatives as potential cancer chemopreventive agents. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Marler, L., Rostama, B., Cushman, M., van Breemen, R., Grubbs, C., and Pezzuto, J.M. Cancer Chemopreventive Potential of Novel Natural Product Derivatives. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

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Park, E-J, Pezzuto, J.M., Morrell, A., and Cushman, M. Induction of RXR transcriptional activity and apoptosis in HL-60 human leukemia cells by natural product-based 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-C]isoquinoline dihydrochloride. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, Hawaii, June 27 to July 1, 2009.

Luqman, S., Meena, A., Marler, L.E., Kondratuyk, T.P., and Pezzuto, J.M. Inhibiton of NFκB activation and aromatase activity by vanilloids: An in vitro and in silico study. Eighth International Congress on Targeted Therapies in Cancer, Washington, DC, August 21-23, 2009.

Morais, M.M.C., Marler, L., Luqman, S., Kondratyuk, T.P., Petronio, M.S., Regasini, L.O., Silva, D.H.S., Bolzani, V.S., Soares, C.P., and Pezzuto, J.M. Chemopreventive potential of natural products isolated from Alchornea glandulosa, Pterogyne nitens and its semi-synthetic analogs. Proceedings of the 7th International Congress of Pharmaceutical Sciences, September, Ribeirao Preto SP, Brazil, September 6-9, 2009.

Pezzuto, J.M., Chang, C-j, Craig, B.A., Cushman, M.S., Fenical, W., Fong, H.H.S., Mesecar, A., Moon, R.C., and van Breemen. R.B. Soliciting Nature’s Help for the Prevention of Cancer. American Institute of Cancer Research, Annual Research Conference on Food, Nutrition, Physical Activity and Cancer, Washington DC, November 5-6, 2009.

Park, E-J, Kondratyuk, T., Morrell, A., Kiselev, E., Cushman, M., and Pezzuto, J.M. Induction of RXR transcriptional activity and consequent up-regulation of p21 by 3-amino-6-(3-aminopopyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline dihydrochloride in MCF-7 breast cancer cells. Frontiers in Cancer Prevention Research 2009, Houston, TX, December 6-9, 2009.

Marler, L.E., Cushman, M., Bin, S., Mesecar, A.D., Jermihov, K., van Breemen, R.B., and Pezzuto, J.M. Aromatase inhibition and chemopreventive potential of novel resveratrol derivatives. Frontiers in Cancer Prevention Research 2009, Houston, TX, December 6-9, 2009.

Murphy, B.T., Kauffman, C.A., Kondratyuk, T., Marler, L., Jensen, P.R., Pezzuto, J., and Fenical, W. Chemopreventive macrolide glycosides from a marine-derived “Solwaraspora” sp. inhibit NF-κB and induce quinine reductase. Proceedings of the Gordon Research Conference on Marine Natural Products, Ventura, CA, February 28-March 5, 2010.

Pezzuto, J.M. Chemoprevention of Human Cancer. Pulama I Ki Ola (Healthcare Conference). University of Hawaii at Hilo, May 21, 2010.

Kondratyuk, T.P., Park, E-J, Marler, L.E., Burns, B.E., Asolkar, R.N., Fenical, W., and Pezzuto, J.M. Marine phenazines inhibit invasiveness of MDA-MB-231 breast cancer cells through extracellular matrix. 51st Annual American Society of Pharmacognosy Meeting, St. Petersburg, Florida, July 10 to 14, 2010.

ul-Haq, I., Park, E-J, Burns, B., Marler, L.E., Mirza, B., Kondratyuk, T.P., and Pezzuto, J.M. Cancer chemopreventive potential of selected medicinal plants from Pakistan. 51st Annual American Society of Pharmacognosy Meeting, St. Petersburg, Florida, July 10 to 14, 2010.

Marler, L., Maiti, A., Cushman, M., and Pezzuto, J. Aromatase specificity of casimiroin analogs. 51st Annual American Society of Pharmacognosy Meeting, St. Petersburg, Florida, July 10 to 14, 2010.

Wright, A.D., Schupp, P., Kohlert-Schupp, C., Pezzuto, J.M., Kondratyuk, T.P., Park, E-J, and Marler, L. Elements of structure elucidation of isolates from the twilight zone sponge

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Suberea sp. collected from waters around Guam. 51st Annual American Society of Pharmacognosy Meeting, St. Petersburg, Florida, July 10 to 14, 2010.

Cheenpracha, S., Tudor, D.D., Park, E.J., Chai ,X.Y., Fernandez, J., Wall, M., Pezzuto, J.M., Chang, L.C. Potential Cancer Chemopreventive agents from the pods and leaves of the medicinal plant Moringa oleifera. 51th Annual Meeting of the American Society of Pharmacognosy & the Phytochemical Society of North America. Florida, USA, July 10-14, 2010.

Morais, M.C.C., Marler, L., Kondratyuk, T.P., Petronio, M.S., Regasini, L.O., Silva, D.H.S., Bolzani, V.S., Pezzuto, J.M., and Soares, C.P. Aromatase inhibition by compounds from Pterogyne nitens (Fabaceae) and semi-synthetic derivatives. 5th Brazilian Symposium on Medicinal Chemistry, Ouro Preto MG Brazil, November 6-9, 2010.

Marler, L.E., Cushman, M., and Pezzuto, J.M. Cancer chemopreventive potential of the marine-derived phenazine, 1-methoxybenzo[b]phenazine. The International Chemical Congress of Pacific Basin Societies Meeting, Honolulu, Hawaii, December 15-20, 2010.

Shen, L., Park, E.-J., Kondratyuk, T.P., Guendisch, D., Marler, L., Pezzuto, J.M., Wright, A.D., and Sun, D. Synthesis of callophycin A analogues and evaluation as potential chemopreventive and anticancer agents. 241st American Chemical Society National Meeting, Anaheim, CA, March 27-31, 2011.

Chen, L., Cushman M., Pezzuto, J.M., and van Breemen, R.B. Human metabolism of AM6-36, a retinoid X receptor-alpha ligand, American Chemical Society National Meeting, Denver, Colorado, June 5-9, 2011.

Pezzuto, J.M., Cushman, M., Fenical, W., Mesecar, A., and van Breemen, R.B. The role of natural products in cancer chemoprevention. 2nd Annual Conference of the American Council for Medicinally Active Plants, Huntsville, Alabama, July 17, 2011.

Fatima, N., Ahmed, S., Kondratyuk, T.P., Park, E.J., Marler, L.E., Youn, U.J., Qazi, M.A., Pezzuto, J.M., Chang, L.C. Cancer chemopreventive potential of endophytic fungi isolated from Taxus baccata. 52nd Annual Meeting of the American Society of Pharmacognosy. San Diego, CA, July 30-August 3, 2011.

Ul-Haq, I., Youn, U.J., Park, E.J., Kondratyuk, T.P., Marler, L.E., Mirza, B., Pezzuto, J.M., and Chang, L.C. Biologically active withanolides from Withania coagulans. 52nd Annual Meeting of the American Society of Pharmacognosy. San Diego, CA, July 30-August 3, 2011.

Pezzuto, J.M. The promise of resveratrol. Recent Advances in the Chemistry of Natural Products, University of São Paulo at São Carlos, Brazil, October 28, 2011.

Pezzuto, J.M., Cushman, M., Fenical, W., Mesecar, A. and van Breemen, R.B. The challenges and promise of cancer chemoprevention: The role of natural products. 3rd Brazilian Conference on Natural Products (BCNP), Ouro Preto, MG, Brazil, October 29-November 2, 2011.

Pezzuto, J.M. The phenomena of resveratrol. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Sun, D., Hurdle, J.G., Lee, R.E., Shen, L., Kondratyuk, T.P., Lee, R.E., Cushman, M., and Pezzuto, J.M. Antimicrobial evaluation of a focused naringenin and resveratrol chemical library. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

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Marler, L.Mayhoub, A., Cushman, M., and Pezzuto, J.M. Thiadiazole and thiadiazole Derivatives of resveratrol as inducers of quinone reductase 1. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Luqman, S., Kondratyuk, T.P., Hoshino, J., Cushman, M., and Pezzuto, J.M. Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylate activity by resveratrol derivatives. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2α-O-acetyl-α-L-rhamnosyloxy)benzyl] isothiocyanate in LPS-stimulated raw 264.7 cells. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Kondratyuk, T.P., Park, E.J., Hirokawa, T., Leong, E., Cushman, M., and Pezzuto, J.M. Resveratrol derivative (E)-4-(3,5-dimethoxystyryl)aniline is a novel inhibitor of cancer cell invasion. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J,, Shen, L., Sun, D., Kondratyuk, T.P., and Pezzuto, J.M. Inhibitory effect of a callophycin A derivative on iNOS expression in lipopolysaccharide-stimulated RAW 264.7 cells. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Park, E.J., Cheenpracha, S., Chang, L.C., Kondratyuk, T.P., and Pezzuto, J.M. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase by epimuqubilin a in RAW 264.7 cells. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Youn, U.J., Park, E.J., Kondratyuk, T.P., Toyama, O., Songsak, T., Wongwiwatthananukit, S., Pezzuto, J.M., and Chang, L.C. Biologically active constitutes from the flower of Vernonia cinerea. 50th Annual Meeting of the Phytochemical Society of North America, Kohala Coast, Hawaii, December 15-20, 2011.

Mayhoub, A.S., Marler, L., Kondratyuk, T.P., Park, E.-J., Pezzuto, J.M., and Cushman, M. Optimization of thiazole analogues of resveratrol for induction of quinone reductase 1 (QR1), 243rd ACS National Meeting & Exposition, San Diego, CA, March 25-29, 2012.

Park, E.-J., Morrell, A., Conda-Sheridan. M., Cushman, M., and Pezzuto, J.M. Characterization of the anti-proliferative effect of 6-(3-aminopropyl)-9-methoxy-3-nitro-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione in cultured PC-3 cells. Annual Meeting of the American Association for Cancer Research, Chicago, IL, March 31-April 4, 2012.

Pezzuto, J.M. The Extraordinary Life of a Simple Stilbene: Resveratrol. 13th Congress of the International Society for Ethnopharmacology, Graz, Austria, Sept. 2-6, 2012.

Pezzuto, J.M. Resveratrol and clinical development. 27ème Seminare en Sciences Pharmaceutiques Programme Doctoral en Sciences Pharmaceutiques, Drugs from Nature: from Discovery to Clinic, Zermatt, Switzerland, Sept. 3-7, 2012.

Pezzuto, J.M. and Park, E.-J. Cancer prevention. 27ème Seminare en Sciences Pharmaceutiques Programme Doctoral en Sciences Pharmaceutiques, Drugs from Nature: from

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Discovery to Clinic, Zermatt, Switzerland, Sept. 3-7, 2012.

Pezzuto, J.M. Biological evaluation of resveratrol and derivatives. Resveratrol 2012, University of Leicester, Leicester, UK, December 5, 2012.

Sang-ngern, M., Youn, U.J., Park, E.-J., Kondratyuk, T.P., Miklossy, G., Simmons, C.J., Turkson, J., Pezzuto, J.M., and Chang, L.C. Anticancer potential of Physalis peruviana (poha). Annual meeting of the American Society of Pharmacognosy, July 14-17, St. Louis, MO.

Pezzuto, J.M. The promise and challenges of cancer chemoprevention. Lecture presented at Shanghai University (June 9, 2014) and Zhejiang University (June 10, 2014), PRC.

Sang-ngern, M., Youn, U.J., Park, E.-J., Kondratyuk, T.P., Miklossy, G., Simmons, C.J., Turkson, J., Pezzuto, J.M., and Chang, L.C. Evaluation of Physalis peruviana (poha) as anticancer agents. Annual meeting of the American Society of Pharmacognosy, July 2014.

Pezzuto, J.M. Resveratrol: A highly permiscuous molecule leads the way to monogamous interactions. 14th International Congress of Ethnopharmacology ISE 2014, Sociedad Latinoamericana de Fitoquimica SLF, Puerto Varas, Chile, September 23-26, 2014.

Pezzuto, J.M. The remarkable life and times of resveratrol (the “Ohdang Plenary Lecture of 2014), Fall Annual Convention of the Pharmaceutical Society of Korea, Gyeongjy, Korea, October 23-24, 2014.

Yu, X., Park, E.-J, Kondratyuk, T.P., Pezzuto, J.M., and Sun, D. Synthesis and evaluation of 2-arylindole derivatives as anticancer and cancer chemopreventive agents. Reveratrol 2014 Conference, Big Island, Hawaii, Dec. 2014.

Pezzuto, J.M. Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. 5th Kuwait International Pharmacy Conference-2015 (“Kuwait International Pharmacy Conference”), Kuwait City, Kuwait, February 1-3, 2015.

Meetings or Symposia Chaired/Organized; Workshops Conducted

Section Chairman, Second International Symposium on Natural Products Chemistry, Karachi, Pakistan, Jan. 22, 1986.

Organizer and Chairman, UIC College of Pharmacy Faculty Retreat, Biotechnology Implementation and Development, The Abbey on Lake Geneva, Fontana, Wisconsin, March 19-21, 1989.

Section Chairman, XVI International Symposium on Natural Products, University of Monterrey, Monterrey, Mexico, April 28, 1989.

Member, Organizing Committee, Norman R. Farnsworth Symposium on Natural Products Research, Congress Hotel, Chicago, Illinois, March 24, 1990 (MC for banquet).

Organizer and Chairman, American Chemical Society Symposium entitled "Contemporary Approaches of Drug Evaluation and Discovery Employing In Vitro Methodology," 200th Annual Meeting of the ACS, Washington, D.C., August 26-31, 1990.

Member, Scientific Program and Organizing Committees, International Research Congress on Natural Products and 32nd Annual Meeting of the American Society of Pharmacognosy, Congress Hotel, Chicago, Illinois, July 21-26, 1991 (MC for banquet).

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Development and Presentation of a Short Course in Cell Culture and Drug Evaluation Procedures, Department of Chemistry, Mahidol University, Bangkok, Thailand, Sept. 26-Oct. 1, 1994.

Presentation of a Short Course and Bioassay Procedures, Universidad Nacional Autonoma de Mexico, Departamento de Farmacia, Facultad de Quimica, Mexico City, Mexico, October 27-29, 1994.

Presentation of an Intensive Laboratory and Lecture Course, New Advances in the Methods for Screening Anticancer Agents, University of Panama, Panama City, April 24-28, 1995 (attended by -25 individuals from various Latin American countries).

Section Chairman, 6th International Symposium on Natural Products Chemistry, Karachi, Pakistan, Jan. 5, 1996.

Theme Coordinator and Session Chair, 12th International Conference on Advanced Science and Technology, Chicago, IL, April 6, 1996.

Section Chairman, 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytotherapy, Munich, Germany, Sept. 11-14, 1996.

Panel Member, symposium entitled "Frontiers in Pharmaceutical Research and Their Impact in Graduate Education," 24th Annual MALTO meeting, University of Arkansas, Little Rock, Arkansas, May 18-20, 1997.

Organizer and Chairman, UIC College of Pharmacy Faculty Retreat, Graduate Education and Postdoctoral Training, Harrison Conference Center, Lake Bluff, IL, June 10-11, 1997.

Presentation of a Short Course and Cell Culture, Universidad Nacional Autonoma de Mexico, Departamento de Farmacia, Facultad de Quimica, Mexico City, Mexico, December 4-6, 1997.

Symposium sponsored by the California Table Grape Commission, lecture and co-organizer, San Francisco, CA, April 30-May 1, 1998 (proceedings have been published).

Member, Organizing Committee, Norman R. Farnsworth Symposium on Botanical Dietary Supplements Research, Drake Hotel, Chicago, Illinois, March 24, 2000 (MC for banquet).

Organizer and Chairman, UIC College of Pharmacy Faculty Enrichment Days, Planning Ahead and Writing the Grant, Harrison Conference Center, Lake Bluff, IL, May 10-11, 2000.

Organizer and Chairman, American Chemical Society Symposium entitled "Chemistry and Biology of Nutritional Supplements and Cancer Chemoprevention," 224th American Chemical Society National Meeting, August 18-22, 2002, Boston, Massachusetts.

National Grape and Wine Initiative (NGWI) Grape Health Workshop, San Francisco, California, December 2-3, 2008 (Moderator, Speaker and Guest Editor for proceedings published in the Journal of Nutrition).

Member, Scientific Committee, 3rd Brazilian Conference on Natural Products (BCNP), Ouro Preto, MG, Brazil, October 29-November 2, 2011.

Member, Scientific and Organizing Committees and Local Host, 50th Annual Meeting of

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the Phytochemical Society of North America, December 10-15, 2011, Fairmont Orchid, Hawaii

Member, Scientific Committee, Resveratrol 2012, University of Leicester, Leicester, UK, December 5-7, 2012.

Member of the Congress Scientific Committee, Sociedad Latinoamericana de Fitoquímica (SLF) and the International Society for Ethnopharmacology (ISP), Puerto Varas, Chile, September, 2014.

Member, Scientific and Organizing Committees, Resveratrol 2014, to be held on the Big Island, Hawaii, December 2014.

Complete Works Reprinted or Abstracted in Secondary Sources

Pezzuto, J.M., Swanson, S.M., and Farnsworth, N.R. Evaluation of the Mutagenic Potential of Phytolacca dodecandra (Endod), a Molluscicide of Potential Value for the Control of Schistosomiasis. In: A. Lemma, D. Heyneman, and S.M. Silangwa (eds.), Phytolacca dodecandra (Endod), pp. 294-299. Tycooly International Publishing Limited, Dublin, 1984 (reprinted from Toxicol. Lett.).

Pezzuto, J.M., Che, C.-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A. DNA as an Affinity Probe Useful in the Detection and Isolation of Biologically Active Natural Products. Condensed by B.B. Jarvis from the original article in J. Nat. Prod. and reprinted in Chemtracts-Organic Chemistry 5: 12-15, 1992.

Betulinic Acid found to have Strong Anticancer Activity. Science/Technology Concentrates, Chemical & Engineering News, Oct. 9, 1995.

Science News Magazine, coverage of betulinic acid, Oct. 1995.

Plant-Derived Agent for Melanoma Treatment. Cancer Watch 5: 9-10, 1996.

Betulinic Acid from Birch Bark May Treat Melanoma, HerbalGram, No. 36, p. 18, 1996.

Grape Compound with Anticancer Activity. Science/Technology Concentrates, Chemical & Engineering News, January 13, 1997.

Grape Expectations. Article written by Varro E. Tyler in Prevention, pp. 80-84, June 1997.

XIIth International Symposium on Plant Originated Crude Drugs. Hacettepe University, Ankara, Turkey, May 20-22, 1998.

Sustainable Development and Conservation of Biodiversity in Vietnam, National Center for Science and Technology, Hanoi, Vietnam, October 2-3, 1998.

Constantinou, A.I., Lucas, L.M., Lantvit, D., Hawthorne, M., Xu, X., Nho, C.W., Jeffery, E.H., Christov, K., van Breemen, R.B., and Pezzuto, J.M. Soy protein isolate prevents chemically-induced rat mammary tumors. Pharm. Biol., 40 (Suppl.): 24-34, 2002. Reprinted in Annual Bibliography of Significant Advances in Dietary Supplement Research, Office of Dietary Supplements, National Institutes of Health, 2003 (NIH Publication No. 04-5450).

Pezzuto J.M., Chang C.-j., Craig, B.A., Cushman, M.S., Fenical, W., Fong, H.H.S., Mesecar, A., Moon. R.C., van Breemen, R.B. Soliciting nature’s help for the prevention of

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cancer: Insights, ingredients from land and sea may fight malignancy. Cancer Prev., Issue 13, 2009. http://www.nypcancerprevention.com/issue/13/cancer_prevention/feature/pezzuto.shtml

Cancer Prevention, Naturally. The difficult search for cancer-preventing natural products takes several paths. Science &Technology, Chemical & Engineering News, June 21, 2010.

Grape Expectations: Unraveling Resveratrol’s Potential. American Institute for Cancer Research Newsletter, p. 12, Summer 2011 (issue 1/2).

Appendix A – Purdue University

Dean, College of Pharmacy, Nursing, and Health SciencesProfessor, Department of Medicinal Chemistry and Molecular Pharmacology

Accomplishments in brief:

Introduction of pharmaceutical care management at Wishard Memorial Hospital

Revision of the Bachelor of Pharmaceutical Sciences curriculum

Establishment of the combined Doctor of Pharmacy (PharmD) and Master of Science in Industrial Administration (MSIA in the School of Pharmacy and Pharmaceutical Sciences

Recruitment of outstanding new faculty members

Full endowment of the Anderson Chair in Pharmacology

Recognition of distinguished alumni, an honorary doctorate, and creation of a career achievement award

Completion and staffing of The Chao Center for Industrial Pharmacy & Contract Manufacturing

Attainment of the $31 million mark in Pharmacy’s participation in the capital campaign

Maintenance of our stature as a top-ranked school of pharmacy

Further enhancement of the Division of Nuclear Pharmacy

Approval to offer Continuing Medical Education

Reinstated management of the animal facility in the Heine Pharmacy Building

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http://www.nypcancerprevention.com/issue/13/cancer_prevention/feature/pezzuto.shtml

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Organizational ChartThe Daniel K. Inouye College of Pharmacy, UH Hilo

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College of Pharmacy - University of Minnesota | - … · Web viewOver the years, I have presented keynote addresses at prominent institutions throughout US, other parts of North American,