Células Madres(Stem Cells)

Harry Alices-Villanueva, Ph.D.Universidad Interamericana de Puerto RIco

Departamento de Ciencias & Tecnología

Referencia

Dedicatoria

Células Madres Humanas:

• ¿Pueden reemplazar células pérdidas?• ¿Pueden tejidos humanos ser recreados por

entero?• ¿Pueden prevenir enfermedades relacionadas

a la vejez?• ¿Podremos encontrar un mecanismo perfecto

para hacer llegar la terapia?• ¿Podremos extender el largo de vida del ser

humano?

¿ Qué es una Célula Madre?

Las células madres sedividen en cuatro subgrupos.

Células Madres Adultas

Ejemplos de Células Madres Adultas

Tejidos deficientes en células madres

¿ Que es diferenciación celular?

Células Madres de Tejidos Fetales

Células Madres Embriónicas

Factores de CrecimientoGrowth Factors

Células Madres por Transplante Nuclear

Retos a afrontar

Ciclo de Vida Celular

Moléculas Importantes del Ciclo Celular

• Kinases

• Cyclin–dependent kinases

• Fosfatasas

Estimular División Celular

• Usted se hace un tajo en un dedo…¿qué ocurre?

Checkpoints…¡otra vez..!

Maturation Promoting Factor (MPF).

Desarrollo del óvulo

ICMTrophoblast

Blastocito

Aplicaciones terapeúticas

Aplicaciones terapeúticas

“Never before has there been such a powerful tool, such a resource that can give so much hope. And to have it just sitting here right in front of us, ready to go while all this debate rages on, is really, really frustrating”

Aplicaciones terapeúticas

“Never before has there been such a powerful tool, such a resource that can give so much hope. And to have it just sitting here right in front of us, ready to go while all this debate rages on, is really, really frustrating”

Christohper Reeve

Debate:

• Religioso• Legal• Ético• Cientifico

Religioso

• The ablation of the inner cell mass (ICM) of the blastocyst, which critically and irremediably damages the human embryo, curtailing its development, is a gravely immoral act and consequently is gravely illicit

– El Vaticano, Agosto 25, 2000

Legal

• The Department of Health and Human Services (DHHS) concluded that the Congressional prohibition [on the funding of embryo research] does not prohibit the funding of research utilizing human pluripotent stem cells because such cells are not embryos.

– National Institutes of Health Guidelinesfor Research Involving HumanPluripotent Stem Cells, 2001.

Ético

• Researches should be asking who this research should be done on, will it work, what will the cost be and who should gain access to it. But because of abortion politics, we spend no tiem at all talking about this.

– Arthur CaplanUniversity of Pennsylvania Center for Bioethics.

Científico

• Most of us in the field think the push to define adult or embryonic cells as better than the other is a lot of folly.

− George DaleyWhitehead InstituteMIT

El Futuro del Debate

• Science facts – in ethics and religion– its most interesting and possibly humbling challenge…while religon must somehow incorporate the discoveries of science to retain credibility.

– Edmund O. Wilson, Consilience

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