CALCIFICATION OF THE THORACIC AORTA ON CHEST X-RAY – ASSOCIATIONS WITH ABDOMINAL AORTIC CALCIFICATION AND PULSE WAVE VELOCITY IN PATIENTS ON RENAL REPLACEMENT THERAPY Schjelderup P. 1 , Jensen J.D. 3 , Otte K.E. 4 , Ladefoged S. 2 , Jensen P.B. 5 , Christensen J.H. 1 1 Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, 2 Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3 Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark, 4 Department of Nephrology, Fredericia Hospital, Fredericia, Denmark, 5 Department of Nephrology, Odense University Hospital, Odense, Denmark Conclusions A significant positive correlation between the extent of AoAC and AAC evaluated by x-ray was found. The presence of AoAC was highly predictive of AAC. Assessment of AoAC on plain chest x-ray can provide valuable initial data on calcification and may have have a role in risk stratification. Further evaluation is required. Chest x-ray showing calcification of the aortic arch. * sectors with calcification. The AoAC score is obtained by dividing sectors with calcification by total number of sectors. Lateral abdominal x-ray showing calcification of the abdominal aorta. Introduction • Vascular calcification is increasingly accepted as a major cause of the extraordinarily high rates of cardiovascular morbidity and mortality in patients on renal replacement therapy (RRT) • Abdominal aortic calcification (AAC) on lateral abdominal x-ray and carotid-femoral pulse wave velocity (PWV) are independent predictors of mortality and non-fatal CV events in patients on RRT • • Guidelines suggest that a lateral abdominal x-ray can be used to detect the presence or absence of vascular calcification for the purpose of risk stratification and management guidance Results • AoAC was significantly positively correlated with AAC (r=0.70, p<0.001) and PWV (r=0.35, p<0.001) • The positive- and negative predictive values of AoAC with respect to AAC were 98% and 32%, respectively. (Using AoAC > 0 as cutoff) Objective To assess whether aortic arch calcification (AoAC) on plain chest x-ray correlates with AAC and PWV, the latter being established markers of vascular calcification. Methods • AAC, AoAC and PWV were measured in 88 patients on RRT • Inclusion criteria: >18 years og age, > 3 months of RRT therapy

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Page 1: CALCIFICATION OF THE THORACIC AORTA ON CHEST X-RAY ...pure.au.dk/portal/files/41908830/Patrick_poster.pdf · Lateral abdominal x-ray showing calciﬁ cation of the abdominal aorta

CALCIFICATION OF THE THORACIC AORTA ON CHEST X-RAY – ASSOCIATIONS WITH ABDOMINAL AORTIC

CALCIFICATION AND PULSE WAVE VELOCITY IN PATIENTS ON RENAL REPLACEMENT THERAPY

Schjelderup P.1, Jensen J.D.3, Otte K.E.4, Ladefoged S.2, Jensen P.B.5, Christensen J.H.1

1Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, 2Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark, 4Department of Nephrology, Fredericia Hospital, Fredericia, Denmark, 5Department of Nephrology,

Odense University Hospital, Odense, Denmark

Conclusions

A signifi cant positive correlation between the extent of AoAC and AAC evaluated by x-ray was found. The presence of AoAC was highly predictive of AAC.

Assessment of AoAC on plain chest x-ray can provide valuable initial data on calcifi cation and may have have a role in risk stratifi cation.

Further evaluation is required.Chest x-ray showing calcifi cation of the aortic arch. * sectors with calcifi cation. The AoAC score is obtained by dividing sectors with calcifi cation by total number of sectors.

Lateral abdominal x-ray showing calcifi cation of the abdominal aorta.

Introduction

• Vascular calcifi cation is increasingly accepted as a major cause of the extraordinarily high rates of cardiovascular morbidity and mortality in patients on renal replacement therapy (RRT)

• • Abdominal aortic calcifi cation (AAC) on lateral abdominal x-ray and carotid-femoral pulse wave velocity (PWV) are independent predictors of mortality and non-fatal CV events in patients on RRT

• • Guidelines suggest that a lateral abdominal x-ray can be used to detect the presence or absence of vascular calcifi cation for the purpose of risk stratifi cation and management guidance

Results

• AoAC was signifi cantly positively correlated with AAC (r=0.70, p<0.001) and PWV (r=0.35, p<0.001)

• • The positive- and negative predictive values of AoAC with respect to AAC were 98% and 32%, respectively. (Using AoAC > 0 as cutoff)

Objective

To assess whether aortic arch calcifi cation (AoAC) on plain chest x-ray correlates with AAC and PWV, the latter being established markers of vascular calcifi cation.

Methods

• AAC, AoAC and PWV were measured in 88 patients on RRT• Inclusion criteria: >18 years og age, > 3 months of RRT therapy