BANFF-CST Joint Scientific Meeting October 5 – 10, 2015 ... · 1 tuesday, october 6, 2015 cst board meeting port hardy start end description 07:00 05:00 closed meeting banff: summary

www.banfffoundation.org www.cst-transplant.ca

BANFF-CSTJointScientificMeetingOctober5–10,2015

Vancouver,BritishColumbia

MONDAY,OCTOBER5,2015BANFF PRE-MEETING: PRECISION DIAGNOSTICS IN TRANSPLANTATION - MOLECULAR PATHOLOGY (MORNING SESSION) GRAND BALLROOM AB + PASSAGE (MODERATORS: ALEXANDRE LOUPY, MICHAEL ME NGEL)

Start End Description

08:00 08:15 Alexandre Loupy, Michael Mengel Introduction and Objective: Consensus in Molecular Transplant Diagnostics

08:15 08:45 Philip Halloran Molecular Assessment and Landscape of ABMR in Kidney Transplants

08:45 09:15 Enver Akalin Clinical and Molecular Significance of Microvascular Inflammation in Kidney Allografts

09:15 09:45 Jeff Reeve Molecular Assessment of TCMR, Mixed Rejection & Borderline Lesions

09:45 10:15 Minnie Sarwal A Cross Organ Common Immune Module for Graft Reejection

Coffee Break

10:30 11:00 Michael Mengel Molecular Assessment of ABMR in Heart Transplants

11:00 11:30 Daniel Salomon What’s New in Non-Invasive Biomarkers: Blood

11:30 12:00 Thangamani Muthukumar What’s New in Non-Invasive Biomarkers: Urine

LUNCH SYMPOSIUM: ANTI-GRAFT ANTIBODIES IN TRANSPLANTATION: IMPROVING THE GOLD STANDARD, IMPLEMENTING COMPLEMENTARY APPROACHES AND MOVING BEYOND HLA (LUNCH PROVIDED WITH SUPPORT FROM ONE LAMBDA. A THERMOFISHER SCIENTIFIC BRAND.) GRAND BALLROOM AB + PASSAGE (MODERATORS: CARMEN LEFAUCHER, ANAT TAMBUR)


12:00 12:30 Anat Tambur What’s Hot - What’s New in HLA Science: Take Home Messages from the 2015 ASHI

12:30 01:00 Adriana Zeevi An Overview of Laboratory Testing Methods in SOT: Value and Limitations

01:00 01:30 Peter Nickerson The Future of HLA: Eplet Mismatch to Improve Transplant Candidates Risk Assessment

BANFF PRE-MEETING: PRECISION DIAGNOSTICS IN TRANSPLANTATION - MOLECULAR PATHOLOGY (AFTERNOON SESSION) GRAND BALLROOM AB + PASSAGE (MODERATORS: ALEXANDRE LOUPY, MICHAEL ME NGEL)


01:30 02:00 Osmar Zaiane Insights of Big Data Analyses in the 21st Century of Biomedical Research

02:00 02:30 Kim Solez Bridge between Transplantation and Regenerative Medicine

02:30 03:00 Kim Solez for Doris Taylor Building New Hearts. Regenerative Medicine Becomes a Reality

Coffee Break

03:30 04:00 Paul Keown Next Generation Sequencing: Applications in Transplant Diagnostics

04:00 04:15

Parmjeet Randhawa An example for Clinical Application - Next Generation Sequencing in Biopsies with Polyomavirus BK Nephropathy: Patient - specific TCR b utilization patterns and presence of unique T-cell clonotypes

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TUESDAY,OCTOBER6,2015CST BOARD MEETING PORT HARDY


07:00 05:00 Closed Meeting

BANFF: SUMMARY OF PREMEETING, BANFF WORKING GROUPS RESULTS AND DIRECTIONS REGARDING BANFF CLASSIFICATION AMENDMENTS (CO-SPONSORED BY RENAL PATHOLOGY SOCIETY) GRAND BALLROOM AB + PASSAGE (MODERATORS: LORRAINE RACUSEN, KIM SOLEZ)


08:00 08:15 Kim Solez, Lorraine Racusen Banff Meeting Intro

08:15 08:30 Kim Solez, Michael Mengel Annual Report from the Banff Foundation

08:30 08:45 Michael Mengel Summary of the Pre-Meeting

08:45 09:00 Parmjeet Randhawa Borderline/TCMR Working Group Update

09:00 09:15 Lynn Cornell Highly Sensitized Working Group Update

09:15 09:30 Banu Sis Molecular Group Update

09:30 09:45 Volker Nickeleit BKv Group Update

09:45 10:00 Helen Liapis Implantation Biopsy Working Group Final Report

Coffee Break

10:30 10:45 Mark Haas The New Diagnostic Criteria for ABMR (Banff 2013): Remarks, Difficulties, Amendments?

10:45 11:00 Banu Sis What Criteria Should Apply to Isolated V Lesions and How To Update the Classification?

11:00 11:15 Volker Nickeleit Prospects for Modifying/Improving the Banff Criteria for Borderline and TCMR

11:15 11:45 M. Haas, B Sis, B Colvin Group Discussion

LUNCH SYMPOSIUM: MTORI IN SOLID ORGAN TRANSPLANTATION: NEW UNDERSTANDINGS, NEW DIRECTIONS AND ADVANCES (LUNCH PROVIDED WITH SUPPORT FROM NOVARTIS) GRAND BALLROOM AB + PASSAGE(MODERATORS: ALEXANDRE LOUPY, CHRISTOPHE LEGENDRE)


12:00 12:20 Federico Oppenheimer Clinical Relevance of New Strategies Using Combined mTORi and Reduced CNI Regimens in Kidney Transplants

12:20 12:40 Guillaume Canaud mTORi for Preventing Antiphospholipid Syndrome Recurrence Post Kidney Transplantation

12:40 01:00 Luciano Potena mTORi Based Strategies for Preventing Chronic Heart Allograft Vasculopathy

BANFF KIDNEY CONCURRENT I: ANTIBODIES AND INJURY TO GRAFT ENDOTHELIUM AND EPITHELIUM GRAND BALLROOM AB + PASSAGE (MODERATORS: LYNN CORNELL, CANDICE ROUFOSSE)


01:00 01:30 Christopher Bellamy Multiplex in situ phenotyping of macrophages in allograft biopsies

01:30 02:00 Roger Wiggins Podocyte Injury After Transplantation: Novel Insights

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02:00 02:30 Candice Roufosse Significance of Double Contours and Peritubular capillary basement membrane multilayering in renal allograft biopsies

02:30 03:00 Robert Colvin The Pathology of Tolerance and ABMR: From Animal Model to Human Biopsies

Coffee Break

03:30 04:00 Elaine Reed Anti-HLA Antibody Binding Trigger Endothelial Cell Signaling: Molecular Pathways and Functional Consequences

04:00 04:30 Annette Jackson Endothelial Cell Rreactive Antibodies: Novel Antigenic Targets Associated With Microvascular Injury in Kidney Transplantation

04:30 05:00 Carmen Lefaucheur Endothelium and Transplant Arteriosclerosis from Heart to Kidney: Epidemiologic Demonstration

BANFF LIVER CONCURRENT I GRAND BALLROOM D (MODERATORS: JACQUELINE O’LEARY, MAX SMITH)


01:00 01:30 Jake Demetris Welcome & Session Goals

01:30 02:00 Luis G. Hidalgo Eosinophils and NK cells in ADCC and Liver Injury

02:00 02:30 Christopher Bellamy Macrophages in Liver Allografts

02:30 03:00 Delsey Neil C4d TMA Concordance Study Results

Coffee Break

03:30 04:00 Geoff McCaughan Liver Allograft Pathology After Effective Anti-HCV Therapies - Changes and Challenges

04:00 04:30 Arnaud Del Bello De Novo DSA: Clinical and Histopathological Manifestations

BANFF LUNG CONCURRENT: CHRONIC LUNG ALLOGRAFT DYSFUNCTION GULF ISLANDS BCD (MODERATORS: CAROL FARVER, DEAN W. WALLACE)


01:00 01:30 Jamie Todd Clinical Features of Chronic Lung Allograft Dysfunction (CLAD)

01:30 02:00 David Hwang Pathophysiology of CLAD/RAS (Restrictive Allograft Syndrome)

02:00 02:30 Elizabeth Pavlisko Pathophysiology of CLAD/BOS (Bronchiolitis Obliterans Syndrome)

02:30 03:00 Rajan Saggar Pathophysiology of CLAD/Chronic Vascular Changes

Coffee Break

03:30 04:00 Carol Farver The Pathology of Antibody-Mediated Rejection in Pediatric Lung Transplantation

04:00 04:30 Nancy Reinsmoen HLA and Non-HLA Donor Specific Antibodies and Clinical Outcomes in Lung TX

04:30 05:00 Group Discussion

CNTRP (POSITIVE STUDY (PROJECT 6) MEETING) GRANVILLE


12:30 05:00 External Meeting

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CST RESEARCH FITS: PLANNING A CAREER IN ACADEMIC TRANSPLANT PROGRAMS ORCA (MODERATOR: JEFFREY SCHIFF)


01:00 01:10 Jeffrey Schiff Opening Remarks

01:10 01:40 Alp Sener Starting a Basic Science Research Program

01:40 02:10 Christine Ribic Starting a Clinical Science Research Program

02:10 02:40 Jeffrey Schiff Creating a Teaching Dossier

02:40 03:00 A. Sener, C. Ribic, J, Schiff Panel Discussion

Coffee Break 03:30 03:55 Breakout Session #1 with Transplant Program Directors 03:55 04:20 Breakout Session #2 with Transplant Program Directors 04:20 04:50 Panel Session with Program Directors

04:50 05:00 Jeffrey Schiff Closing Remarks

PROBE MEETING GALIANO

Start End Description 04:00 05:30 External Meeting

SPONSOR COCKTAIL RECEPTION CONSTELLATION SUITE

Start End Description 05:00 06:00 By Invitation only

CANADIAN PEDIATRIC GROUP BUSINESS MEETING & SESSION FINBACK (MODERATORS: AVIVA GOLDBERG, SEEMA MITAL)


06:00 06:30 Aviva Goldberg Welcome and Introductions

06:30 07:00 Brendan Keating Discovering Genomic Underpinnings of Rejection and Complications in Transplantation

07:00 07:15 Chia Wei Teoh Trainee Abstract Award Presentation

07:15 07:30 Updates on Research Initiatives, New Collaborative Research 07:30 08:00 Business Meeting (Members only)

EXHIBIT HALL GRAND BALLROOM CD

Start End Description 06:00 11:45 Exhibitor Setup

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WEDNESDAY,OCTOBER7,2015JOINT AST-BANFF-CST SYMPOSIUM GRAND BALLROOM AB + PASSAGE (MODERATORS: JIM ALLAN, STEVEN PARASKEVAS, KIM SOLEZ)


07:00 07:20 Rob Fairchild Tests of T Cell Reactivity

07:20 07:40 Kathryn Tinckam Failure to Adopt: Screening for Donor Specific Antibodies

07:40 08:00 Robert Colvin Mixing mRNA and microscopes: The Biopsy with and without molecular diagnostics

08:00 08:20 Roslyn Mannon Is the Problem Failure to Demonstrate the Added Value of the Test(s) or a Lack of Therapeutics?

POSTER SETUP GRAND BALLROOM CD

Start End Description 07:00 09:30 Wednesday Poster Boards – Poster Setup

JOINT PLENARY SESSION #1: FUTURE DIRECTIONS OF TRANSPLANTATION: EXPANDING THE DONOR POOL AND IMPLEMENTING NEW TECHNOLOGIES GRAND BALLROOM AB + PASSAGE (MODERATORS: JOSEPH KIM, GREG KNOLL)


08:30 08:40 Steven Paraskevas, Kim Solez Presidents’ Opening Remarks

08:40 09:05 John Gill Extending the donor pool: New registries, allocation, and policies: North American perspectives

09:05 09:25 Christian Jacquelinet Extending the donor pool: New registries, allocation, and policies: European perspectives

Coffee Break among Posters

10:00 10:25 Darren Freed Extending the Donor Pool II: Preservation Across Different Organs (Pulsatile Perfusion Devices)

10:25 10:50 Julie Ho Implementing Omics into Daily Practice: Taking the Road and the Lessons from Nephrology

PRESIDENTS’ MEETING GULF ISLANDS BCD


LEADING CLINICAL PRACTICES COMMITTEE MEETING GULF ISLANDS BCD


JOINT ORAL ABSTRACT PRESENTATIONS - SESSION I GRAND BALLROOM AB + PASSAGE (MODERATORS: PROSANTO CHAUDHURY, ALEXANDRE LOUPY)


11:00 11:10 Marion Rabant Heterogeneity of isolated v lesions in kidney transplantation

11:10 11:20 Darren Freed Ex vivo perfusion in a loaded state improves the preservation of donor heart function

11:20 11:30 Sacha De Serres Critical Apparaisal of the New Banff Criteria for Chronic Antibody-Mediated Rejection in the Real Life Setting

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11:30 11:40 Qianni Hu Mitochondrial Damage-Associated Molecular Patterns (MTDs) released from hepatic ischemia reperfusion induce inflammatory response

11:40 11:50 Alexandre HERTIG Markers of Endothlial-to-mesenchymal transition: evidence for Antibody-Endothelium interaction during antibody-mediated rejection

11:50 12:00 Anand Ghanekar Differentiation of Functional Cholangiocytes from Human Pluripotent Stem Cells for the Modeling of Biliary Disease

LUNCH SYMPOSIUM: COMPLEMENT-MEDIATED DISEASES IN RENAL TRANSPLANTS AND THEIR LINK TO ABMR (LUNCH PROVIDED WITH SUPPORT FROM ALEXION PHARMACEUTICALS) GRAND BALLROOM AB + PASSAGE (MODERATORS: KATHRYN TINCKAM)


12:00 12:20 Christophe Legendre Targeting Complement in Recurrent Atypical Haemolytic Uraemic Syndrome

12:20 12:40 John Gill The Role of Complement and Complement Inhibition in Recurring Glomerulonephritis

12:40 01:00 Steven Sacks Targeting Complement for Preventing Delay Graft Function

CANADIAN KIDNEY TRANSPLANT WORKING GROUP BUSINESS MEETING GALIANO

Start End Description 01:00 05:30 Closed Meeting (Members only)

CANADIAN LIVER TRANSPLANT NETWORK (CLTN) BUSINESS MEETING GALIANO


BANFF LIVER CONCURRENT II FINBACK (MODERATORS: CHRISTOPHER BELLAMY, STEFAN HUBSCHER)


01:00 01:30 Stefan Hubscher Pathophysiologic Mechanisms of Liver Allograft Injury/Fibrosis

01:30 02:00 Sandy Feng Long-Term Follow-up and Weaning Immunosuppression in Pediatric Recipients: Factors Influencing the Graft

02:00 02:30 Jacqueline O'Leary Chronic Antibody-Mediated Rejection: Perspectives and Issues

Coffee Break among Posters 03:30 05:00 Group Discussion

BANFF PANCREAS CONCURRENT I: UPDATE ON PANCREAS ALLOGRAFT PATHOLOGY ISSUES / II: ACCURATE DETERMINATION OF THE CAUSE OF GRAFT LOSS IN WHOLE PANCREAS TRANSPLANTS ORCA (MODERATORS: CINTHIA DRACHENBERG, JON ODORIC)


01:00 01:25 Danniele Holanda Utility of Duodenal Cuff Biopsies for Diagnosis of Pancreas Rejection

01:25 01:50 Erik Larsson CMV Infection of the Duodenal Cuff in Whole Pancreas Allografts

01:50 02:15 Megan Troxell Pale Acinar Nodules and Other Peculiar Histological Findings in Pancreas Allografts

02:15 02:40 Hanneke de Kort Clinical and Diagnostic Issues Regarding Vascular Lesions in Pancreas Allografts

02:40 03:00 María Toniolo Clinical Impact of Performing Concurrent Pancreas-Kidney Allograft Biopsies


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03:30 03:55 John Papadimitriou Morphological Spectrum of Lesions Associated with Graft Failure in Pancreas Transplants

03:55 04:20 David Klassen Graft Failure in Whole Pancreas and Islet Transplants: UNOS Perspective

04:20 04:45 Rainer Gruessner Clinical Aspects of Pancreas/Islet Failure

04:45 05:10 Steven Paraskevas Clinicopathological Algorithm for the Accurate Etiological Diagnosis of Graft Failure in Pancreas Transplants

05:10 05:30 Closing Comments, Future Plans, Group Discussion BANFF HEART CONCURRENT I & II: IMPROVING HEART TRANSPLANT REJECTION DIAGNOSTIC SYSTEM: UNMET NEEDS, CURRENT LIMITATIONS, NEW IMPLEMENTATIONS AND FUTURE DIRECTIONS PAVILLION BALLROOM C (MODERATORS I: GERALD BERRY, LORI WEST; MODERATORS II: REX NEAL SMITH)


01:30 01:50 Patrick Bruneval The Pathological Classification of Antibody-Mediated Rejection: Certainties, Uncertainties and Prospects for its Improvement

01:50 02:10 Adriana Zeevi DSA in Thoracic Transplant: Where Do We Stand?

02:10 02:35 Annalisa Angelini Microcirculation Injury in Acute and Chronic Heart Rejection

02:35 03:00 Elaine Reed Endothelial Cell in Cardiac AMR: Interplay Between Antibodies, Complement, and Leukocytes


03:30 04:00 Dylan Miller Modern Pathology of CAV in the Era of AMR

04:00 04:30 Thomas Thum MicroRNAs and Small Non-Coding RNA’s in Heart Transplantation: Tissue and Sera

04:30 05:00 Scott Tebbutt Leukocyte Transcripts as Biomarkers in Cardiac Transplantation

05:00 05:30 Group Discussion ALLIED HEALTH GROUP SESSION & BUSINESS MEETING PAVILLION BALLROOM D


01:30 01:45 Janet Madill Welcome and Introductions

01:45 02:30 Sean Spina Technology in Clinical Practice. How the Digital Revolution is Affecting Patient Care.

02:30 03:00 Nancy Howes The TONE Program: The Transplant ONline Exercise Program. How Physiotherapists Can Use Technology to Promote Preoperative Exercise


03:30 04:10 Daniel Buchman The Illusion of Privacy

04:10 04:17 Tania Janaudis-Ferreira Physical Activity Participation in Solid Organ Transplant Recipients: What are the Barriers and Facilitators?

04:18 04:25 Natalia Liapounova Pediatric pre-transplant cognitive function, behavior problems and lung allocation system (LAS) scores.

04:26 04:33 Holly Mansell A qualitative analysis of pre-transplant educational needs from the post-transplant perspective

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04:34 04:41 Tania Janaudis-Ferreira Changes in functional outcomes after an inpatient rehabilitation program for solid organ transplant recipients

04:45 05:20 Allied Health Business Meeting (Members only) 05:20 06:30 Networking Session with CANRESTORE

CANADIAN DONATION GROUP BUSINESS MEETING PAVILLION BALLROOM AB


POSTER DISMANTLE GRAND BALLROOM CD

Start End Description 07:00 07:30 Wednesday Poster Boards – Poster Dismantle

OKTOBERFEST SOCIAL VANCOUVER ART GALLERY ROOFTOP

Start End Description 07:30 11:00 Ticketed social event

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 9:30AM) GRAND BALLROOM CD Alvita Chan Impact of Social Determinants of Health on Liver Transplantation Antoine Roux DSA characteristics associated with antibody mediated rejection in Lung Transplantation. Berna Yelken The Effect of C1q Test Done Before Kidney Transplantation on Acute Rejections: Center Experience Chee Loong Saw Pattern of Pre- and Post-Transplant Anti-HLA Antibody Detection in Pediatric Renal Transplant Recipients Isabelle Lapointe Eplet Analysis Supports Easier Identification and Exclusion of Allele Specific HLA Antibodies Joseph Kim Early Hospital Readmissions Following Kidney Transplantation: A Systematic Review Luis G. Hidalgo A CASE OF HEART VALVE REPLACEMENT LEADING TO EXTENSIVE SENSITIZATION - AN EXAMPLE OF THE WORST HLA CLASS II TYPING FOR A TRANSPLANT RECIPIENT Maria Picken Adenovirus Infection in Kidney Transplant Recipients María Toniolo Simultaneous pancreas-kidney transplant: Histologic evaluation Ngan Lam Validation of Kidney Transplantation Using Administrative Data Nicholas Dawson DESIGN AND OPTIMIZATION OF MASS CYTOMETRY TO MEASURE IMMUNE RECONSTITUTION POST-HEMATOPOEITC STEM CELL TRANSPLANT Patrick Luke WARM BLOOD-BASED REPERFUSION WITH CORM-401 REDUCES ISCHEMIA REPERFUSION INJURI (IRI) IN AN EX-VIVO PORCINE MODEL OF THE DONATION AFTER CIRCULATORY DEATH KIDNEY DONOR Renata Ponsirenas Enhancing positive predictive values for antibody mediated rejection through improved antibody characterization RK Sharma Donor Specific Antibodies (DSA) in living related transplantation Sait Sen EVALUATION OF PATIENTS WITH ANTIBODY MEDIATED REJECTION AFTER KIDNEY TRANSPLANTATION Tomokazu Shimizu Subclinical tacrolimus nephrotoxicity in protocol biopsies obtained more than 5 years after renal allograft transplantation Trana Hussaini Investigating the Association between Hypomagnesaemia and Calcineurin Inhibitor Induced Nephrotoxicity in Liver Transplant Recipients: A Case-Control Study Yasemin Ozluk The efficacy of immunoadsorbtion in the treatment of late antibody mediated rejection

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 3PM) GRAND BALLROOM CD Andre Teixeira THE ROLE OF POSTREPERFUSION BIOPSIES IN LIVER TRANSPLANTATION; CORRELATION BETWEEN CLINICAL, LABORATORIAL AND HISTOPATHOLOGICAL FINDINGS Bahman Afzali From ultrastructure to molecular testing: Assessment of antibody-mediated tissue injury in human cardiac allograft biopsies Berna Yelken Protocol biopsy is very important for kidney graft survival in desensitize patients Heather Stevenson Isolated obliterative arteriopathy in liver allografts should prompt evaluation for underlying chronic antibody-mediated rejection Johann Moritz Kaths Normothermic Ex Vivo Kidney Perfusion Represents a Novel Preservation Method for Heart Beating Donor Kidney Grafts Marie-Chantal Fortin Donors’ and recipients’ views on altruistic unbalanced paired kidney exchange Maryam Demian Higher Self Efficacy and Simplification of Dosing Regimen are Predictive of Better Medication Adherence in Adult Renal Transplant Recipients Maud Racape A NEW DIAGNOSTIC SCORE FOR MICROVASCULAR INFLAMMATION IN ANTIBODY MEDIATED REJECTION IN HEART TRANSPLANTATION Medhat Askar Comparison Between IgG and IgM De Novo Donor Specific HLA Antibody (dnDSA) Characteristics Among Patients with Symptomatic and Asymptomatic Antibody Mediated Rejection in Heart Transplant Recipients Olusegun Famure THE LONG-TERM CARE OF KIDNEY TRANSPLANT RECIPIENTS: WHAT IS THE ROLE OF THE GENERAL NEPHROLOGIST Oyedele Adeyi Active Sinusoidal Infiltrate and EBV Infection in Post-Liver Transplant Biopsies RK Sharma Loss of suppressive function of CD4+CD25+FOXP3+ T regulatory cells in renal patients with chronic allograft dysfunction in late post transplant period Shirin Aladwan ADVERSE SYMPTOMS OF IMMUNOSUPPRESSANTS: PILOT SURVEY OF SOLID ORGAN TRANSPLANT RECIPIENTS Tahani Alamodi KIDNEY TRANSPLANTATION IN A PEDIATRIC PATIENT WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME AND A NOVEL C3 GENE VARIANT Theone Paterson Personality factors positively predict medication adherence as measured via self-report and tacrolimus blood level post-assessment. Vanessa Michaud Transition from pediatric to adult healthcare: Evaluation of the medical and psychosocial outcomes of a Young Adult Clinic for renal transplant recipients. Yasemin Ozluk The link between recurrent glomerular diseases and allograft rejection: Under immunosuppression

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 6PM) GRAND BALLROOM CD Alison Gareau Serum proteins are significantly upregulated in patients with clinical antibody-mediated rejection Asami Takeda Pathological diagnosis of subclinical chronic antibody-mediated rejection in kidney allografts with de novo positive donor-specific antibodies – usefulness of C4d positivity in glomerular capillaries Berna Yelken The impact of repeated allograft biopsies on indication of Eculizumab rescue treatment in patients with serious antibody mediated rejection Bing Yang PRE-EXISTING ANTI-LG3 ANTIBODIES AGGRAVATE RENAL ISCHEMIA-REPERFUSION INJURY AND CORRELATE WITH AN INCREASED RISK OF DELAYED GRAFT FUNCTION Boris Gala-Lopez Anti-aging Glycopeptide Protects Human Islets Against Tacrolimus-related Injury and Facilitates Engraftment Daisuke Toki Interstitial Fibrosis is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy Esme Dijke Enhanced suppressive capacity of regulatory T cells (Tregs) expanded from human thymus in the presence of rapamycin. Istvan Mucsi Ethnicity as a potential barrier to pre-transplant evaluation completion in a Canadian setting James Lan Unambiguous HLA Genotyping using Long-Range PCR and Next-Generation Sequencing (NGS) on Buccal-Extracted DNA: Results from 4,000 Donor Recruitment Samples Joseph Kim Vitamin D Levels and Post-Transplant Diabetes Mellitus After Kidney Transplantation Kasia Sablik IVIG AND HIGH DOSE STEROID TREATMENT OF TRANSPLANT GLOMERULAPATHY EFFECTIVELY SLOWS PROGRESSION OF LOSS OF RENAL ALLOGRAFT FUNCTION Minal Borkar BK polyomavirus orchestrates renal fibrosis through epigenetic modulations and induces necroptosis in renal tubular cells Patrick Luke IMMUNOSUPPRESSIVE ACTIONS OF CARBON MONOXIDE RELEASING MOLECULE (CORM-401) ON TOLL-LIKE RECEPTORS AND RENAL ISCHEMIA REPERFUSION INJURY Rahul Chanchlani Are Hypomagnesemia and Hypokalemia Novel Risk Factors for New-Onset Diabetes in Pediatric Solid Organ Transplant Recipients Renata Ponsirenas Circulating anti-HLA IgG subclasses detected after transplantation indicate subclass switching during progression of antibody-mediated rejection Sait Sen THE EFFECT OF HYPERCALCEMIA ON TUBULOINTERSTITIAL CALCIFICATION OF THE ALLOGRAFT Tomokazu Shimizu Clinical and pathological analyses of chronic vascular rejection after kidney transplantation Yasemin Ozluk Retrospective analysis of glomerulitis scoring by the last (Banff 2013) criteria: A single center observation

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 6:30PM) GRAND BALLROOM CD An-Hang Yang The association of microvascular remodeling and expression of mesenchymal phenotypes in renal allografts with chronic active antibody-mediated rejection Ana Konvalinka Quantification of Angiotensin II Signature Proteins in Urine of Patients with Kidney Allograft Berna Yelken Are the characteristics of antibody mediated rejection predictive for the long term allograft survival? Candice Roufosse C4d positivity in renal biopsies without microcirculation inflammation or injury Chia Wei Teoh Mycophenolic acid levels are not associated with clinical adverse events at 3 months post-renal transplantation Daniel Seron Inflammation either associated or not with fibrosis at 6 week protocol biopsies is an independent predictor of 1 year DSA Dima Kabbani Vascular Jump Grafts in Liver Transplant: Do They Transmit Cytomegalovirus? Harsharan Singh Urinary Polyomavirus Haufen are Biomarkers for Polyomavirus Nephropathy: Mouse & Man & Proof of Concept Holly Mansell ELEVATED CIRCULATING INTERLEUKIN 33 LEVELS IN STABLE RENAL TRANSPLANT RECIPIENTS AT HIGH RISK FOR CARDIOVASCULAR EVENTS Karen Sherwood TOWARDS CLINICAL NGS HLA-TYPING: A PERFORMANCE COMPARISON OF NEXT-GENERATION SEQUENCING TECHNOLOGIES FOR DNA HLA TYPING IN A CLINICAL DIAGNOSTIC ENVIRONMENT Maria Cristina Ribeiro de Castro Microcirculation inflammation in early surveillance renal biopsy in sensitized patients did not correlate with graft outcome. Melanie Dieude Tissue injury enhances circulating levels of active proteasome and triggers anti-LG3 production Muhtashim Mian Evaluation of a Novel Global Immunity Assay to Predict Clinical Outcomes in Organ Transplant Recipients Natalie Montwill Iron-dependent ferroptosis mediates microvascular endothelial cell survival following cardiac allograft transplantation Roslyn Mannon The Missing Link in Kidney Allograft Loss: Renal Fibroblast Activation by Anti-Class I MHC Antibody Sacha De Serres Longitudinal Assessment of the Phenotype and Function of Monocytes in De Novo Kidney Transplant Recipients Trana Hussaini HCV Infection Interaction with Gender and Calcineurin Inhibitor Induced Chronic Renal Failure in Liver Transplant Recipients: A Case-Control Study Walter Park 120 Protocol Renal Allograft Biopsies at 10 Years Suggest New “Causes” of Chronic Injury Yasemin Ozluk Microcirculation inflammation and arteriolar hyalinosis predict graft loss in renal transplants without extensive scarring

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THURSDAY,OCTOBER8,20152015 STATUS REPORT ON ABMR (BREAKFAST PROVIDED WITH SUPPORT FROM ASTELLAS PHARMA INC.) GRAND BALLROOM AB + PASSAGE (MODERATORS: ED KRAUS, CHRIS WIEBE) Start End Description

07:00 07:20 Patricia Campbell Epidemiology of ABMR

07:20 07:40 Mark Haas Pathophysiology and Diagnostics of ABMR

07:40 08:00 Alex Loupy Risk Stratification and Disease State Assessment in ABMR

POSTER SETUP GRAND BALLROOM CD

Start End Description 07:00 09:30 Thursday Poster Boards – Poster Setup

ALLIED HEALTH GROUP – CANRESTORE MEETING GULF ISLANDS BCD


JOINT PLENARY SESSION #2: FROM BASICS TO THERAPEUTICS IN ABMR GRAND BALLROOM AB + PASSAGE (MODERATORS: HEINZ REGELE, PAUL KEOWN)


08:00 08:30 Stuart Knechtle Improving Our Understanding of ABMR: What Are The Lessons From Non-Human Primate Models?

08:30 08:50 Nicole Valenzuella The Role of Macrophages in ABMR

08:50 09:10 Luis G. Hidalgo Targeting ADCC and NK Cells in ABMR

09:10 09:30 David Rush Clinical Relevance of Subclinical/Indolent Kidney Rejection Phenotypes


10:00 10:20 Denis Glotz What Are Our Surrogates for Treatment Efficacy in ABMR?

10:20 10:40 Stan Jordan Complement Blockade in ABMR: Results and Perspectives

10:40 11:00 Robert Montgomery Protocols for Preventing/Treating ABMR: Results and Perspectives

JOINT ORAL ABSTRACT PRESENTATIONS - SESSION II GRAND BALLROOM AB + PASSAGE (MODERATORS: JAG GILL, MICHAEL MENGEL)


11:00 11:10 Jussi Tikkanen De novo DQ-donor-specific antibodies are associated with chronic lung allograft dysfunction after lung transplantation

11:10 11:20 Sarah Higgins Identifying the specific causes and the determinants of outcome in kidney recipients with Transplant Glomerulopathy: a multicenter study.

11:20 11:30 Caren Rose Should the Kidney Donor Risk Index (KDRI) be used to quantify deceased donor quality in Canada?

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11:30 11:40 Babak Orandi Presentation and Outcomes of C4d-Negative Antibody-Mediated Rejection After Kidney Transplantation

11:40 11:50 Marie Achille The psychology and ethics of organ donation in the context of assisted suicide in Quebec.

11:50 12:00 Antoine Roux Lung transplantation outcome is mainly driven by antibody mediated rejection

LUNCH SYMPOSIUM: MINIMIZATION, COMPLIANCE AND ABMR (LUNCH PROVIDED WITH SUPPORT FROM ASTELLAS PHARMA INC.) GRAND BALLROOM AB + PASSAGE (MODERATORS: DANIEL SERON, TOM BLYDT-HANSEN)


12:00 12:20 Chris Wiebe De novo DSA: Prevalence, Pathophysiology and Allograft Injury

12:20 12:40 Beth Foster Risk for ABMR in Adolescence: HLA-Matching, Recipient Age, and Compliance

12:40 01:00 Thomas Nevins Predictive Patterns of Early Medication Adherence in Renal Transplantation

BANFF KIDNEY CONCURRENT II: DONOR SPECIFIC ANTI-HLA MEDIATED ALLOGRAFT INJURY AND BEYOND HLA JUNIOR BALLROOM CD (MODERATORS: PATRICIA CAMPBELL, ALEX MAGIL)


01:00 01:30 Mark Haas How Many ABMR Phenotypes Do Actually Exist? Consequences for Patient Care

01:30 02:00 Adriana Zeevi Complement Binding Capacity of Anti HLA Antibodies: Multiorgan Clinical Relevance

02:00 02:30 Carmen Lefaucheur Anti HLA DSA IgG Subclasses and Distinct Allograft Injury

02:30 03:00 Duska Dragun Beyond HLA: Relevance of Other Targets


04:30 05:00 Stuart Greenstein Consensus Discussion #3: Definition of New Working Group: Clinico-Pathological Consensus for the Assessment of Time Zero Donor Biopsies

BANFF VASCULARIZED COMPOSITE ALLOGRAFTS (VCA) JUNIOR BALLROOM AB (MODERATORS: CINTHIA DRACHENBERG, ALTON FARRIS)


01:00 01:05 Linda Cendales Welcome & Session Goals

01:05 01:33 Anil Chandraker Histologic Features of Antibody Mediated Rejection after Face Transplantation

01:33 02:03 Jean Kanitakis Graft Vasculopathy in the Skin After a Vascularized Composite Allograft

02:03 02:31 Adela Rambi Cardones Skin in Transplantation

02:31 02:59 Gerald Brandacher Expanding the Banff VCA Criteria

Coffee Break among Posters 03:30 05:00 Group Discussion

CANADIAN PANCREAS GROUP BUSINESS MEETING ORCA


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CST PLENARY: ID GRAND BALLROOM AB + PASSAGE (MODERATORS: ATUL HUMAR, ALISSA WRIGHT)


01:00 01:30 Nazia Selzner New Therapies for HCV

01:30 02:00 Peter Stock Transplanting the HIV+ Patient (and HIV+/HCV+), The HOPE Act

02:00 02:30 Glen Westall Viral infection and Allograft Rejection in the Lung

02:30 03:00 Atul Humar Viral Infection and the Allograft Rejection (Non-Lung)

Coffee Break among Posters CST JOINT ETHICS & CRITICAL CARE SESSION: ISSUES IN DCD DONATION GRAND BALLROOM AB + PASSAGE (MODERATORS: REBECCA GREENBERG, ADRIAN ROBERTSON)


03:30 03:55 Sonny Dhanani Death Determination in Organ Donation

03:55 04:20 Robert Sibbald Ethical Issues in DCD

04:20 04:45 Charlotte Harrison Pediatric DCD and Lessons Learned from Debating and Implementing a DCD Policy in a Pediatric Hospital

04:45 05:30 Panel Discussion CST PHARMACIST GROUP BUSINESS MEETING & SESSION FINBACK


03:30 04:15 Joseph Kim Immunosuppressant Exposure Variability

04:15 05:00 David Taber Medication Errors in Transplantation

05:00 05:45 Trana Hussaini Re-thinking Immunosuppression in Liver Transplantation: A Focus on Minimization

05:45 06:00 Coffee Break 06:00 07:30 Pharmacist Group Business Meeting (Members only)

TTS WOMEN IN TRANSPLANTATION NETWORKING SESSION PAVILLION BALLROOM CD

Start End Description 05:00 06:00 The Transplantation Society – WiTS Networking

POSTER DISMANTLE GRAND BALLROOM CD

Start End Description 07:00 07:30 Thursday Poster Boards – Poster Dismantle

EXHIBIT HALL DISMANTLE GRAND BALLROOM CD

Start End Description 07:00 011:00 Exhibition Dismantle

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 9:30AM) GRAND BALLROOM CD Alton Farris NK Cell Activation Characterizes Chronic Antibody Mediated Rejection Catriona Mckenzie Oral nicotinamide to reduce nonmelanoma skin cancer in renal transplant recipients: a pilot Phase 2 randomized controlled trial Daniel Fantus The impact of novel adenosine triphosphate-competitive inhibitors (TORKinibs) on alloimmunity and transplant survival G. V. Ramesh Prasad Transplantation and the Nature of the Immune Self Jessica Forcucci Grading Capillaritis (ptc) in Renal Transplant Rejection: Can Ancillary Studies Improve Interobserver Variability Karishma Kak Patient Self-reported Adherence to and Perceptions towards Immunosuppressive Medications at the Outpatient Renal Transplant Clinic Kosuke Masutani Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation in resolving polyomavirus BK nephropathy Luis G. Hidalgo GENE EXPRESSION CHANGES IN NK CELLS FOLLOWING CD16 ACTIVATION - EVIDENCE FOR CD16 ENGAGEMENT IN BIOPSIES WITH ABMR Luis G. Hidalgo MOLECULAR ASSESSMENT OF THE COGNATE EVENTS IN T CELL- AND ANTIBODY-MEDIATED REJECTION – TWO DIFFERENT CELLS WITH MANY KEY COMMON PROGRAMS Meghan Kapp Endothelial Activation and Lymphangiogenesis in Humoral Rejection of Kidney Transplants Naima Carter-Monroe DUAL LEUKOCYTE/ENDOTHELIAL STAIN FOR ASSESMENT OF ENDOCAPILLARY INFLAMMATION IN THE RENAL ALLOGRAFT Nithya Krishnan CD45 Counts in Post Perfusion Biopsy Predicts AMR Pallav Gupta Acute and Chronic calcineurin inhibitor toxicity in live renal allograft recipients: clinical and histological features Patrick Luke First Canadian Experience with DCD Simultaneous Kidney Pancreas Transplantation Ryan Rochon Rhabdomyolysis after Hand Assisted Laparoscopic Donor Nephrectomy: Our Centre's Experience Stephen Quigley Acute Necrotizing Pancreatitis Following Living Kidney Donation - A Case Report and Systematic Review of the Literature. Thomas Brian McGregor Right versus Left Laparoscopic Donor Nephrectomy : Initial 3 year Experience From a Single Centre Transplant Program. Xiu Qing (Jenny) Wang Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of Molecular Chimerism in Murine Neonatal Tolerance

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 3PM) GRAND BALLROOM CD Benjamin Adam The NanoString gene expression platform is technically robust and feasible for routine formalin-fixed paraffin-embedded transplantation pathology applications Carlos Cervera Evaluation of qualitative and quantitative Epstein-Barr virus (EBV) DNA detection in whole blood at time of Post-transplant lymphoproliferative disorder (PTLD) diagnosis Catherine Burton Age of Clearance of Passive Maternal CMV IgG in Infants Awaiting Solid Organ Transplant Christina Kaufman Graft rejection in hand transplant recipients with grade 0 skin biopsy histology Craig Hasilo Inhibition of Neutrophil Migration Enhances Early Engraftment in a Nude Mouse Model of Human Islet Transplantation Dale Lien Combined use of extended release and regular release tacrolimus in a child with cystic fibrosis and high tacrolimus trough level variability post lung transplantation Hongji Yang Combination of Novel Anti-CD45RB and Anti-CD40 Chimeric Antibodies Promotes Operational Tolerance with a Distinct Signature of Immunoregulatory Cells in Cynomolgus Monkey Renal Allograft Recipients Hyeon Joo Jeong Immunophenotype of Inflammatory Cells in Isolated V-Lesion of Allograft Kidney Jee-Young Han Clinico-pathologic characteristics of C4d negative antibody mediated rejection in renal allografts Jorge Malheiro GRAFT PATHOLOGY AND DONOR-SPECIFIC DE NOVO ALLOSENSITIZATION IN THE NATURAL HISTORY OF KIDNEY TRANSPLANTATION: A CASE-CONTROL ANALYSIS Julie Allard PATIENTS’, CAREGIVERS’ AND RESEARCHERS’ PERSPECTIVES ON RESEARCH PRIORITIES IN ORGAN TRANSPLANTATION IN CANADA. Jutta Krista Preiksaitis Residual risk of transfusion-acquired cytomegalovirus (CMV) infection in CMV seronegative solid organ transplant recipients receiving CMV seronegative organs and leukoreduced cellular blood products Olusegun Famure MEDICAL AND NON-MEDICAL PREDICTORS OF COMPLETING THE TRANSPLANT EVALUATION PROCESS IN END-STAGE RENAL DISEASE (ESRD) PATIENTS. – A SINGLE CENTRE STUDY Roslyn Mannon Understanding the Milieu of Brain Death: Donor Monocyte Chemoattractant Protein 1 (MCP-1) Predicts Recipient Allograft Function Sunita Singh The Epidemiology of Pancreta Discard: An SRTR Analysis Tariq Aljohani EBV-positive lymphoid infiltrate in a renal surveillance biopsy mimicking subclinical T-cell mediated rejection Virginie Royal Eculizumab for the treatment of severe antibody-mediated rejection: a case report and review of the literature

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 6PM) GRAND BALLROOM CD Benjamin Adam Internal and external validation of a molecular diagnostic for antibody-mediated rejection in routine formalin-fixed paraffin-embedded renal allograft biopsies Christina Dörje Does total inflammation in early kidney graft biopsies predict progression of fibrosis and transplant function at 1 year post-transplant? Dayanand Deo Renal Histogenomics: Gene fingerprint to predict Delayed Graft Function Elizabeth Martinez Acute Vascular Lesions in the Kidney Transplant and Relationship to Cellular and Antibody-Mediated Rejection (ABMR) Erin Ready Post-transplant lymphoproliferative disorder in adult kidney transplant patients: a British Columbia experience G. V. Ramesh Prasad TRANSPLANT TOURISM IS AN INDEPENDENT RISK FACTOR FOR LONG TERM KIDNEY ALLOGRAFT LOSS Hanneke de Kort Comparison of methods for assessment of peritubular capillary basement membrane multilayering (PTCBML) Heounjeong Go Refining the diagnostic criteria of transplant capillaropathy for chronic antibody-mediated rejection Jan Ulrich Becker Pathologists' individual approach to the diagnosis of Banff Borderline T-cell mediated rejection Joseph Kim Validation of Predictive Nomograms for Delayed Graft Function in Canadian Kidney Transplant Recipients Julie Allard Organ donation after cardiac death for a conscious patient: new ethical issues Li-Zzu Lin Primary hepatic angiosarcoma treated with living dornor liver transplantation Marie Wright Long-term respiratory morbidity in recipients of pediatric solid organ transplants: a retrospective review. Rajan Duggal Clinicopathologic spectrum of plasma cell–rich acute rejection: An aggressive morphologic form of acute rejection Ruth Sapir-Pichhadze Kidney Transplant Outcomes following Alemtuzumab Induction and a Steroid-Free Protocol vs. rATG Induction and Maintenance Steroids Seyed M Hosseini-Moghaddam Antiviral Prophylaxis against Early-Onset Post-Transplant Lymphoproliferative Disease in Epstein-Barr Virus Seronegative Renal Transplants, Single Arm Cohort Study Shaifali Sandal Renal Resistance Measured during Pulsatile Perfusion and Long-Term Kidney Transplant Outcomes Szu-Han Wang Predictors of biliary leakage after T-tube removal in living donor liver transplantation recipients

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JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 6:30PM) GRAND BALLROOM CD Alberto González-Almada Histologic Findings in Pre-transplant AT1Rab + ve Patients: Increase in Sub-intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies. C Deblais DIFFUSE, INTENSE, LINEAR (DIL) C4d GLOMERULAR CAPILLARY POSITIVITY IS A STRONG MARKER FOR THE DIAGNOSIS OF CHRONIC ANTIBODY MEDIATED REJECTION. Erik Larsson Systematic morphological evaluation of consecutive protocol biopsies of the duodenal cuff in clinical pancreas transplantation Farsad-Alexander Eskandary The prevalence of late HLA-DSA-positive antibody-mediated rejection in kidney transplant recipients and the diagnostic value of antibody properties: Results of a large prospective cross-sectional study Istvan Mucsi Mental health and behavioral barriers to completing the pre-transplant evaluation Istvan Mucsi African Canadian and Asian Canadian patients are less likely to have potential living donors when first presenting for evaluation: A single center experience James Lan Clinical Relevance of Complement-Activating Donor-Specific Antibodies Identified by a Novel C3d Assay in Predicting Kidney Allograft Failure Johan Molne Rejection patterns and a grading system for cervical biopsies after human uterus transplantation Joseph Kahwaji Pathological Finidngs in HLA Sensitized Patients Treated with Everolimus: Interim Results Joseph Kim Incidence, Risk Factors, and Clinical Outcomes of BK Virema in the Modern Era of Kidney Transplantation Kyla Naylor Frequency of Bone Mineral Density Testing in Adult Kidney Transplant Recipients Marie-Chantal Fortin Patients’ Perspectives on Cardiovascular Risk Factors after Kidney Transplantation Michael Moser Early experience with machine cold perfusion of living donor kidneys Nada Alachkar IgA nephropathy recurrence after kidney transplantation Ngan Lam Gender Differences in Use of Prescription Narcotic Medications among Living Kidney Donors Rhea Varughese A Single Centre’s Lung Transplantation Experience for Pulmonary Graft versus Host Disease Shigeo Hara Granular swollen epithelial cells in the kidney allograft: a marker for kidney allograft senescence? Sunita Singh External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients

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FRIDAY,OCTOBER9,2015PUBLIC SOLICITATION AND DIRECTED ANONYMOUS DONATION SYMPOSIUM GRAND BALLROOM AB + PASSAGE (MODERATOR: STEVEN PARASKEVAS) Start End Description 07:00 08:00 Breakfast Symposium BANFF SUMMARY PAVILLION BALLROOM D Start End Description 08:00 12:00 Banff Summary CST LIVER CONCURRENT SESSION JUNIOR BALLROOM B (MODERATORS: IAN ALWAYN, MARKUS SELZNER) Start End Description 08:00 09:00 Sandy Feng

Liver Transplantation for HCC-Milan, UCSF, TTV: Where do we go? 09:00 09:15 Karen Pineda-Solis

“Functional” Warm Ischemia Time as a Predictor of Graft Failure and Biliary Complications. 09:15 09:30 Juan Echeverri

Subnormothermic Ex-Vivo Liver Perfusion (SNEVLP) Reduces Endothelial Cell Damage and Bile Duct Injury after Pig Liver Transplantation with HBD Grafts

09:30 09:45 David Forner Donor Specific Antibodies in Liver Transplantation: Do Complement Fixing Antibodies Predict Outcomes?

09:45 10:00 Ahmed Alqallaf Correlation of Serum Creatinine-Based Equations With Radionuclide GFR in Candidates for Liver Transplantation

10:30 10:45 Nazia Selzner Debate: Is six months abstinence required for liver transplantation in patients with alcohol induced liver disease? PROS

10:45 11:00 James Shapiro Debate: Is six months abstinence required for liver transplantation in patients with alcohol induced liver disease? CONS

11:00 11:15 Juan Echeverri Live Donor Liver Transplantation with Older (>50years) vs Younger (<50years) Donors: Does Age Matter?

11:15 11:30 Trana Hussaini Immunosuppression practices in liver transplantation: A survey of North American Centres

11:30 11:45 Juan Echeverri Fast Track of Adult-to-Adult Live Donor Liver Transplant Recipients: Avoiding ICU Admission Reduces Complications and Post Transplant Hospital Stay

11:45 12:00 Ibrahim Al Hasan The Fate of the DCD Liver Follows the Kidney

CST LUNG CONCURRENT SESSION JUNIOR BALLROOM A (MODERATOR: LIANNE SINGER) Start End Description 08:00 08:45 Glen Westall

Making Sense of Antibodies before and after Lung Transplantation 08:45 09:30 Jussi Tikkanen

Antibodies in Lung Transplantation - What do we know and what can we do? 09:30 09:40 Alim Hirji

Clinical Judgment Versus Lung Allocation Score in Predicting Waitlist Mortality 09:40 09:50 Nader Aboelnazar

The Value of Hypoxic Pulmonary Vasoconstriction in Determining Lung Health During Ex-Vivo Lung Perfusion

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09:50 10:00 Katie Kinaschuk Evolving strategies for Mechanical Circulatory Support in Bridging prior to Lung Transplantation

10:30 10:40 Sunita Mathur Persistent Skeletal Muscle Weakness And Atrophy After Lung Transplantation

10:40 10:50 Dale Lien Donor Specific Antibody (DSA) Associated With Significant Bilateral Upper Lobe Pleural Thickening And Lung Graft Dysfunction

CST-CSN JOINT KIDNEY-PANCREAS CONCURRENT SESSION PAVILLION BALLROOM C (MODERATORS: RAMESH PRASAD, JAG GILL) Start End Description 08:00 08:40 Hatem Amer

Treasure in the Waste-Post Transplant Proteinuria 08:40 09:20 G. V. Ramesh Prasad

Metabolic Syndrome, Chronic Kidney Disease, and Transplantation 09:20 10:00 Greg Knoll

Post-Transplant Malignancy 10:30 10:40 Cecilia Kwok

Caspase-8 has paradoxical function in ischemia-reperfusion injury versus transplantation due to differences in intracellular pH

10:40 10:50 Melanie Dieude The 20S proteasome activity within apoptotic nanovesicles controls immune responses to the allograft

10:50 11:00 Ryan Cunnington Epithelial-to-Mesenchymal transition as a mechanism for BK virus induced kidney fibrosis

11:00 11:10 Kevin Wen IgA Nephropathy: HLA Class II zero mismatch living donor kidney transplantation associated with increased recurrence and graft loss

11:10 11:20 Sunita Singh Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure?

11:20 11:30 Olusegun Famure Neighbourhood-level socioeconomic predictors for completing the assessment and progressing to kidney transplant among referred end-stage renal disease patients

11:30 11:40 Ye Su Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)

11:40 11:50 Michael Moser Protection of the transplant kidney from preservation injury by inhibition of matrix metalloproteinases

11:50 12:00 Tom Blydt-Hansen Urine metabolites as biomarkers for kidney antibody-mediated rejection

12:00 12:10 Gaurav Tripathi Genetic Predisposition to Interleukin-10 production influences Epstein–Barr Virus Reactivation after Renal Transplantation

CST DONATION CONCURRENT SESSION PAVILLION AB (MODERATOR: ADRIAN ROBERTSON) Start End Description 08:30 09:15 Adrian Robertson

Space and Time of Discussions with Donor Families. 09:15 10:00 Sonny Dhanani

Donation Physician Specialists 10:30 11:00 Robert Sibbald

Consent to Donation is Trickier Than it Looks

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11:00 11:10 Michael Moser What messages are potential donor families receiving from the Internet about Donation after Cardiac Death?

11:10 11:20 Daniel Buchman Organ Donation after Physician Assisted Death in Canada: Ethical and Legal Issues

11:20 11:30 Elizabeth Hendren Where should the public learn about organ donation: Health Care Settings or the DMV?

11:30 11:40 Samantha Anthony Family Veto in Organ Donation

11:40 11:50 Caren Rose The number of HIV-infected potential deceased organ donors in Canada

11:50 12:00 Maeghan Toews Family Override of Consent for Organ Donation: The Disconnect between Law and Policy

12:00 12:10 Sonny Dhanani Increase In Neurologic Determination Of Death (NDD) Organ Donation In The Donation After Cardiac Death (DCD) Era. The Ontario Experience.

CST HEART CONCURRENT SESSION JUNIOR BALLROOM C (MODERATORS: LORI WEST, BRUCE MCMANUS) Start End Description 09:00 09:30 Bruce McManus

Biomarkers for Monitoring Cardiac Allograft Rejection: Ready for Prime Time? 09:30 10:00 Michael Mengel

Antibody Mediated Rejection in Heart Transplantation: What Is The Diagnostic Gold Standard in 2015?

10:30 10:42 Xusheng Zhang Prolongation of Cardiac Allograft Survival through Targeted Silencing of TLR Adaptor Genes using Mannose Liposome

10:42 10:54 Medhat Askar Association of Complement Activation Product C5a with Allosensitization in Patients with Ventricular Assist Devices

10:54 11:06 Ye Su Intracellular OPN is an essential protective factor to cardiac endothelial cell and the long term heart graft survival

11:06 11:18 Stanley Araujo Reactivation Chagoma in Heart Transplanted patients

11:18 11:30 Mark Kearns Donor Death and Cardiac Injury After Withdrawal of Life Support in a Rodent DCD Protocol

11:30 11:42 Bruce Motyka Tolerance to A-Antigen Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model

11:42 11:54 Cecilia Kwok CD4+ T-cell mediated microvascular endothelial cell death in a chronic cardiac allograft rejection model involves RIPK3

11:54 12:06 Romy Hoeppli Tailoring Homing Capacity of Thymic Regulatory T Cells by Expansion in Cytokine-enriched Culture Conditions

CST RESEARCH COMMITTEE MEETING GULF ISLANDS BCD Start End Description 12:30 01:30 External Meeting CNTRP SESSION GRAND BALLROOM AB + PASSAGE Start End Description 01:00 02:00 Canadian National Transplant Research Program Session

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CST FELLOWSHIP PRESENTATION GRAND BALLROOM AB + PASSAGE (MODERATOR: RAMESH PRASAD) Start End Description 02:00 02:15 Esme Dijke

Transplantation in infancy: exploring pathways to tolerance induction PANEL ON QUALITY IN TRANSPLANTATION GRAND BALLROOM AB + PASSAGE (MODERATORS: PROSANTO CHAUDHURY, JOHN GILL) Start End Description 02:30 02:50 Greg Knoll

An introduction to Quality. What is Quality? How does one measure it? 02:50 03:10 Dorry Segev

What is being done in the US? Program specific reporting (PSR) and how it works. 03:10 03:30 Stuart Greenstein

TransQIP and beyond 03:30 04:00 Panel Discussion 04:00 04:15 Coffee Break CST ANNUAL GENERAL MEETING GRAND BALLROOM AB + PASSAGE Start End Description 04:15 05:45 Closed Meeting (Members only) CST BOARD MEETING GULF ISLANDS BCD Start End Description 06:00 06:30 Closed Meeting (Members only) CONFERENCE DINNER & AWARDS GALA PAVILLION BALLROOM CD Start End Description 07:30 10:00 Ticketed Social Event

SATURDAY,OCTOBER10,2015CST LUNG GROUP BUSINESS MEETING PORT ALBERNI Start End Description 09:00 12:00 Closed Meeting (Members only)

Documents

BANFF-CST Joint Scientific Meeting October 5 – 10, 2015 ... · 1 tuesday, october 6, 2015 cst board meeting port hardy start end description 07:00 05:00 closed meeting banff: summary