Annual ReportREDMO 2014

Donors Available donors. Evolution

Available typed donors as of 12/31/2014 ▲ 24% 164 749

The number of donors registered by REDMO will not match the numbers presented by the NTO nor the various Regional Transplant Coordinations. REDMO only considers as valid those donors who report all basic data and have their HLA typed. The NTO and Autonomous Communities include within their data all donors who signed and informed consent, an who also provided a sample for HLA typing at a later point.

2

6625 11726 17331 22760 27008 32743 36489 39732 42440 46013 50705 54517 5815165438

7416280314 83361

93366107003

132335

164749

0

20000

40000

60000

80000

100000

120000

140000

160000

180000

1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

▲ 24%

▲ 24%

DonorsAvailable donors. Distribution by typing quality

3

HLA-A, B, C and DR (or A, B, C, DR and DQ) typed donors (25%) 40 483

HLA-A, B and DR (or A, B, DR and DQ) typed donors (56%) 93 058

HLA-A and B (or A, B and C) typed donors (19%) 31 208

0

10000

20000

30000

40000

50000

60000

70000

80000

90000

100000

A + B (o A + B + C) A + B+ DRB1 (o + DQB1) A + B + C + DRB1(o + DQB1)

DonorsAvailable donors. Distribution by age and gender

Average donor age(Standard deviation ± 9,26) 41 By gender

Male (42%) 69 463

Female (58%) 95 286

By age

Men Women

18 to 30 9 274 16 678

31 to 40 21 072 30 873

41 to 50 27 322 33 141

51 to 60 11 795 14 594

4

0

5000

10000

15000

20000

25000

30000

35000

18 to 30 31 to 40 41 to 50 51 to 60

Men Women

DonorsAvailable donors. Distribution by Autonomous Community (1 of 3)

3%2%

6%

1% 5%

1%6%

1%16%

11%

3% 3%9%

20%

2%

4%

5%

Available donors by Autonomous Community

5

334692426

35183072

70552411

53959835

2714715384

49864150

1764389259546

81681255

16867129

AndalusiaAragonAsturias

Balearic IslandsCanary Islands

CantabriaCastile La Mancha

Castile LeonCataloniaValencia

ExtremaduraGaliciaMadridMurcia

NavarraBasque Country

RiojaCeutaMelilla

Andorra

DonorsAvailable donors. Distribution by Autonomous Community (2 of 3)

Availabledonors

Averageage

% by gender(male / female)

x 100 000 people

Andalusia 33 469 39 55 / 45 398,33

Aragon 2 426 42 55 / 45 183,04

Asturias 3 518 46 60 / 40 331,34

Balearic Islands 3 072 43 61 / 39 278,40

Canary Islands 7 055 41 58 / 42 335,18

Cantabria 2 411 40 64 / 36 409,58

Castile La Mancha 5 395 41 59 / 41 259,55

Castile Leon 9 835 42 55 / 45 394,22

Catalonia 27 147 42 59 / 41 361,05

Valencian Community 15 384 43 58 / 42 307,38

Extremadura 4 986 43 60 / 40 453,42

Galicia 4 150 43 62 / 38 150,98

Madrid (Community of) 17 643 39 59 / 42 273,35

Murcia 8 925 45 58 / 42 608,46

Navarra 9 546 43 56 / 44 1489,72

Basque Country 8 168 44 61 / 39 373,14

Rioja (La) 1 255 43 62 / 38 393,41

Ceuta (Autonomous City) 168 43 48 / 52 197,73

Melilla (Autonomous City) 67 42 34 / 66 79,28

6

DonorsAvailable donors. Distribution by Autonomous Community (3 of 3)

Registered donors per 100 000 inhabitants

n=352

7

0,00

200,00

400,00

600,00

800,00

1000,00

1200,00

1400,00

4729 4723 4681

8480 8741 95398175 8429

14010

25828

32929

0

5000

10000

15000

20000

25000

30000

35000

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

DonorsEvolution of donor registration

Typed donors throughout 2014 ▲ 27% 32 929

8

Start of National BM Plan

Donors2014 donors (n=32 929). Distribution by age and gender

Average donor age for 2014(Standard deviation ± 9,44) 37

By gender

Male (41%) 13 531

Female (59%) 19 398

By age

Men Women

18 to 30 3 364 6 136

31 to 40 4 886 6 983

41 to 50 4 231 5 043

51 to 60 1 050 1 236

9

0

1000

2000

3000

4000

5000

6000

7000

8000

18 to 30 31 to 40 41 to 50 51 to 60

Men Women

Female59%

Male41%

DonorsDonor cancellations

Donors cancelled throughout 2014 577

Reasons for donor cancellation

Disease 138

Unreachable 130

Stem-cell donation 69

Voluntary withdrawal 67

Over 60 46

Duplicates 35

Ethical reasons 29

Transferred to other registries 28

Deceased 10

Other reasons 25

10

24%

22%

12%

12%

8%

6%

5%

5%2% 4%

Disease UnreachableStem-Cell donation Voluntary withdrawalOver 60 DuplicitiesEthical reasons Transferred to other registriesDeceased Other reasons

DonorsWorldwide distribution (n=24 606 023). By continents

8 342 946 9 489 473

3 084 712

188 276

3 431 778

68 838

11

DonorsWorldwide distribution. By country

12

0

100000

200000

300000

400000

500000

600000

700000

800000

900000

1000000 1 022 3673 394 812

5 778 9967 944 349

DonorsEurope’s distribution. Registered donors

13

0

50000

100000

150000

200000

250000

300000

350000

400000 1 022 367

5 778 996

740 491

DonorsEurope’s distribution. Registered donors per 1 000 inhabitants

14

0,00

10,00

20,00

30,00

40,00

50,00

60,00

70,00

80,00 159,58

DonorsRequests for donor typing (1 of 2)

Total number of typing requests ▲7% 3 916

Results received from typing requests ▲ 23% 3 196

Results from requests throughout 2014 2 672

Results from requests throughout 2013 556

Request canceled prior to results 216

2014 requests pending results 1 028

Average response time (days) ▲ 28% 50

15

0500

10001500200025003000350040004500

2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Requests received Requests with results

DonorsRequests for donor typing (2 of 2)

Distribution of 2014 requests by requesting country

Spain (80%) 3 138

United States 169

Germany 166

France 159

Canada 75

Turkey 35

Switzerland 27

Romania 19

Italy 18

Australia 13

Belgium 13

Hungary 13

Iran 13

Israel 10

Poland 9

Denmark 8

United Kingdom 6

Austria 4

Portugal 4

Norway 3

Others 14

16

DonorsVerification typing sample requests (1 of 2)

Number of verification typing sample requests ▲ 36% 644

Samples shipped throughout 2014 ▲ 37% 485

Samples shipped for requests made in 2014 472

Samples shipped for requests made in 2013 13

Sample requests cancelled prior to shipment 123

2014 sample requests pending shipment 49

Average response time (days) ▼12% 15

17

0

100

200

300

400

500

600

700

2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Requests received Samples sent

DonorsVerification typing sample requests (2 of 2)

Distribution of 2014 requests by requesting country

Spain (33%) 211

United States 207

Germany 57

France 38

United Kingdom 31

Italy 12

Canada 10

Netherlands 10

Argentina 8

Switzerland 8

Austria 7

Australia 5

Czech Republic 5

Poland 5

Turkey 5

Romania 4

Greece 3

Others 18

18

DonorsStem-cell collections performed (1 of 5)

Number of stem-cell collections throughout 2014 ▲ 27% 80

By product

Bone Marrow ▲ 22% 11

Peripheral Blood ▲ 27% 65

Lymphocyte collection 4

19

17

914 13

43 43

2328

20 22 20

37

2009 2010 2011 2012 2013 2014

National patient International patient

DonorsStem-cell collections performed (2 of 5)

Distribution of collections by country of destination

Spain (54%) 43

Germany 8

France 7

Italy 5

United States 5

Switzerland 4

Argentina 2

Belgium 1

Canada 1

Slovenia 1

Netherlands 1

Israel 1

United Kingdom 1

20

Spain54%

Germany10%

France9%

Italy7%

United States

6%

Switzerland5%

Argentina3%

Belgium1%

Canada1% Slovenia

1%

Netherlands1%

Israel1%

United Kingdom

1%

DonorsStem-cell collections performed (3 of 5). Distribution of donors by gender and age

Average donor age for effective donors(Standard deviation ± 8,27) 39

21

0

5

10

15

20

25

30

18 to 25 26 to 35 36 to 45 45 to 60

Men Women

Male66%

Female34%

DonorsStem-cell collections performed (4 of 5)

22

Distribution of Stem-Cell donations by donors’ residence (AC)

21

14

10

65 5

3 3 3 2 2 2 2 1 1

DonorsStem-cell collections performed (5 of 5)

Distribution of collections by collection centers

MO SP LIN

Andalusia (14)

Hospital Carlos Haya 1 3

Hospital de Jerez 1

Hospital Reina Sofía 1 3

Hospital Virgen de las Nieves 1

Hospital Virgen del Rocío 1 3

Aragon (4) Hospital Miguel Servet 3 1

Asturias (1) Hospital Central de Asturias 1

Balearic I. (1) Hospital Son Espases 1

Canary I. (2) Hospital Dr. Negrín 2

Castile Leon (3) Hospital Clínico de Salamanca 2 1

Catalonia (11)Hospital Clínic 2

Hospital de Sant Pau 8 1

Galicia (2)Complexo Hospitalario de A Coruña 1

Complexo Hospitalario de Santiago 1

Madrid (25)

Hospital de la Princesa 3

Hospital Gregorio Marañón 3 5

Hospital La Paz 5

Hospital Puerta de Hierro 1 2

Hospital Ramón y Cajal 1 5

Murcia (2) Hospital Virgen de la Arrixaca 2

Navarra (3) Hospital de Navarra 3

Valencia (5) Hospital Clínico de Valencia 4 1

Basque C. (7) Hospital Donostia 7 23

Andalusia18%

Arago4%

Asturias1%

Balearic Islands

1%

Canary Islands

3%

Castile Leon3%

Catalonia13%Galicia

3%

Madrid33%

Murcia3%

Navarra4%

Valencia5% Basque

Country9%

Umbilical cord blood unitsEvolution of number of umbilical cord blood units available

Umbilical cord blood units available as of December 31st, 2014 ▲ 3% 60 437

Umbilical cord blood units added in 2014 ▼ 18% 3 084

793

2029 46

68 7779 10

877

1256

6

1527

1

1742

1

2073

2

2446

2

2880

1 3600

5 4177

1 4732

4 5237

7

5550

9

5884

8

6043

7

19

97

19

98

19

99

20

00

20

01

20

02

20

03

20

04

20

05

20

06

20

07

20

08

20

09

20

10

20

11

20

12

20

13

20

14

24

Umbilical cord blood unitsAvailable cord blood units. Distribution by bank

Bank Number of units *

TNC>1x10^9

AvailableCD34+

MalagaCastile La Mancha 1 247Murcia 99

22 649(22 387) 64 % 83 %

BarcelonaNavarre 896Extremadura 544Aragon 415Balearic Islands 271Cantabria 319Andorra 45

17 952(17 204) 76 % 100 %

MadridLa Rioja 98

7 283(7 127) 61 % 100 %

GaliciaCastile Leon 393Asturias 216

6 136(6 053) 39 % 99 %

Valencia 4 833(4 815) 63 % 100 %

Basque Country 1 018(696) 100 % 100 %

Tenerife 454(453) 34 % 3 %

Vidacord 102(103) 31 % 100 %

Ivida 10(10) 70 % 100 %

* 2013 data in parenthesis

25

Evolution of available cord blood units by CBB

0

5000

10000

15000

20000

25000

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Malaga Barcelona Madrid

Galicia Valencia Basque Country

Tenerife

Umbilical cord blood unitsWorldwide distribution (n=622 223). By continents

26

230 908244 186

112 594

28 1426 393

Umbilical cord blood unitsCord blood units available per 100 000 people

27

292,50 261,00

166,11

153,10

129,95

119,80 69,04

66,36

61,42

53,90

51,96

51,76

50,23

42,47

37,97

36,98

32,99

32,02

29,23

26,98

20,81

13,18

9,34

5,72

5,29

4,78

4,33

2,33

1,74

0,93

0,26

0,12

Umbilical cord blood unitsTyping requests

Number of typing requests ▼2% 295

Results received for typing requests ▼16% 272

Results from requests throughout 2014 270

Results from requests throughout 2013 0

2014 requests pending results 23

Average response time (days) = 11

28

0

20

40

60

80

100

120

Umbilical cord blood unitsDNA sample requests for confirmatory typing

Number of confirmatory typing requests ▼ 3% 381

Samples shipped throughout 2014 ▲2% 359

Samples shipped for requests made throughout 2014 353

Samples shipped for requests made throughout 2013 6

2014 sample requests pending 6

Average response time (days) ▼25% 6

29

0

5

10

15

20

25

30

35

40

45

50 298

Umbilical cord blood unitsCBU shipments (1 of 3)

Number of CBU’s shipped throughout 2014 ▼ 23% 246

By cord blood bank

Nationalpatients

Internationalpatients

Total

Barcelona 30 (47) 99 (145) 129 (192)

Malaga 7 (12) 67 (67) 74 (79)

Valencia 5 (14) 7 (5) 12 (19)

Madrid 6 (2) 17 (20) 23 (22)

Galicia 0 (0) 3 (4) 3 (4)

Basque Country 1 (2) 3 (2) 4 (4)

Tenerife 0 (0) 0 (0) 0 (0)

Ivida 0 (0) 1 (0) 1 (0)

Vidacord 0 (0) 0 (0) 0 (0)

Total 49 (77) 197 (243) 246 (320)

* 2013 data in parenthesis

30

1 3 412

23

74

129

Umbilical cord blood unitsCBU shipments (2 of 3)

Shipment distribution by country of destination

Spain 49

United States 46

France 45

Colombia 31

Netherlands 16

United Kingdom 9

Mexico 8

Italy 7

Canada 6

Turkey 4

Australia 4

Hungary 3

Austria 2

Belgium 2

Chile 2

Greece 2

Norway 2

Uruguay 2

Germany 1

Lithuania 1

New Zeland 1

Poland 1

Portugal 1

Switzerland 1 31

Umbilical cord blood unitsCBU Shipments (3 of 3) Evolution by cord blood banks

32

Evolution of CBU shipments by cord blood banks

0

50

100

150

200

250

2007 2008 2009 2010 2011 2012 2013 2014

Barcelona Malaga Madrid Valencia Basque Country Galicia Tenerife Ivida

Spanish donationsEvolution of Spanish donations

33

1 4 11 7 14 12 21 17 27 24 27 3345 42 37 40 39 32 35

6080

8 17 27 2437 31 33

5475

123

153178

228

339

308286

317

246

1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

BM/PB donations CBU shipments

Spanish DonationsCumulative Spanish donations

34

0

500

1000

1500

2000

2500

3000

1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

BM/PB donations (n=608) CBU shipments (n=2 484)

National PatientsEvolution of number of searches

Searches initiated in 2013 855

By product

Bone marrow and/or peripheral blood 407

Umbilical cord blood 42

Bone marrow and/or peripheral blood, and umbilical cord blood 406

Search evolution for Spanish patients (n= 855)

35

138 156 134 131 94 85 102 138 90 91 105 115 121 101 125 132 130 142224 229 250 309

40797 108 118

119120 147

202 185 228 242334

416 427534

531628

489489

406

6 15

11

7 13

1013

22

3261 42

1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

PB/BM PB/BM + CBU CBU

National PatientsSearches started. Search type

By type

First time search 768

Second or subsequent searches* 87

* Reasons for second-time searches

Search for new donors 26

Second transplant 31

Transplant with a donor located through the previous search 23

Cord Blood transplant 7

Evolution of average patient age for first time searches

36

2123

25 2426 27 28

30 3133 34

37 37 3840 39

41

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

Average age

National PatientsStarted searches. By diagnosis

By diagnosis

1st search(n=768)

2nd search(n=87)

Acute Myeloblastic Leukemia 220 24

Acute Lymphoblastic Leukemia 134 8

Myelodisplastic Disorders 98 10

Non-Hondgkin’s Lymphoma 102 10

Monoclonal Gammopathies 46 8

Severe Aplastic Anemias 41 4

Hondgkin’s Lymphoma 21 1

Other Leukemias 45 1

Inherited Immune System Disorders 12 4

Chronic Myeloid Leukemia 17 0

Inherited Erythrocyte Abnormalities 5 6

Other Malignancies 9 2

Other Non-Malingnant Diseases 7 2

Inherited Metabolic Diseases 5 6

Histiocytosis 6 1

Evolution of main diagnosis for all searches

37

0

50

100

150

200

250

300

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

ALL AML CML MDS Lymphoma Inherited Dis.

1,56

1,94

1,27

1,85

1,78

2,55

1,09

1,971,27

2,681,10

2,36 3,23

0,981,84

0,821,17

2,38 0,00

National PatientsStarted searches. By patient residence

By Autonomous Community (n=855)

Andalusia 131

Aragon 13

Asturias 25

Balearic Islands 13

Canary Islands 41

Cantabria 19

Castile – La Mancha 17

Castile – Leon 46

Catalonia 189

Valencian Community 92

Extremadura 12

Galicia 54

Madrid (Community of) 81

Murcia 26

Navarra 7

Basque Country 58

Rioja (La) 4

Ceuta (Autonomous City) 0

Melilla (Autonomous City) 0

Foreign 27

Nomber of searches started in Spain per 100 000 inhabitants (2014) 1,78

Started searches by patient’s residence per 100 000 inhabitants

38

National PatientsStatus of searches

Active searches as of 01/01/2014 198

Active searches as of 31/12/2014 ▼ 26% 147

Deactivated searches as of 31/12/2014 293

Active searches with a suitable donor 15

Searches cancelled throughout 2014 862

Reasons for search deactivation

Located donor 278

CBU selected (pending infusion) 4

Other reasons 11

Reasons for cancellation

Unrelated transplant 452

Regulations (see details) 135

Deceased 91

Related transplant 64

Bad clinical condition 49

Other (changes in HLA, relocating to other registries …) 21

Lymphocyte infusion 20

Switching therapies 14

Optimal clinical condition 11

Patient’s voluntary withdrawal 5

Searches cancelled due to regulations

Deactivated searches> 1 year (without donor) 9

Deactivated searches> 1 year (with donor) 82

Seaches active for 1 year 44

39

National PatientsStatus of searches

40

532 first donors located (69%)•198 BM/PB transplants (37%)• 225 deactivated•103 cancelled• 6 active

106 cancelled•45 TPH CBU•61 other reasons

5 deactivated searches

125 active searches• 85 included during last term

(68%)

768 New searchesstarted

*(2013 data in parenthesis)

National PatientsLocated donors

Patients with one or more located donors (BM/PB) 607 (585)

Donors located throughout 2014 (BM/PB) 1 076 (982)

Average time for BM/PB searches deactivated afterdonor was located (days)Standard deviation ± 46,66

47 (59)

Median time for searches deactivated in 2014 afterdonor was located (days) 36 (41)

CBU selections carried out by REDMO’s office throughout SCU 2014 82 (62)

Evolution of the number of located donors

0

200

400

600

800

1000

1200

2 0 0 0 2 0 0 2 2 0 0 4 2 0 0 6 2 0 0 8 2 0 1 0 2 0 1 2 2 0 1 4

41

Median for BM / PB searches in days

9180

6858

50 5160

54 52 50 48 49 45 41 36

2000 2002 2004 2006 2008 2010 2012 2014

National PatientsLocated donors. Summary of located donors by country of origin

42

2014 (n= 1076) 2013 (n=982) 2012 (n=952)

Germany (37%) 395 (39%) 381 (56%) 533

United States (18%) 191 (22%) 214 (22%) 211

Spain (13%) 145 (11%) 113 (5%) 46

United kingdom 74 59 38

Israel 51 33 16

Portugal 50 43 31

Poland 47 38 18

France 27 23 19

Italy 19 14 7

Canada 18 11 6

Belgium 15 8 5

Brazil 9 13 1

Netherlands 8 4 3

Switzerland 7 8 5

Sweden 5 3 0

Austria 4 1 0

Argentina 2 0 0

Australia 2 2 7

Denmark 2 3 0

Norway 1 4 0

Others 4 7 6

National PatientsLocated donors

Time to locate BM/PB donors by percentages

Before 3 months 93%

Between 3-6 months 4%

Between 6-10 months 2%

Between 10-12 months 0,5%

Over 12 months 0,5%

43

60

65

70

75

80

85

90

95

2006 2007 2008 2009 2010 2011 2012 2013 2014

Donors located before 3 months

National PatientsProbability of donor with 7/8, 8/8, 9/10 or 10/10 identity (2010-2014)

44

Probability of donor with 7/8, 8/8, 9/10 or 10/10 identity

0 1 2 3 4 5 6 7 8 9 10 11 12

Search time (months)

1

0,8

0,6

0,4

0,2

0

Act

uari

al p

roba

bilit

y of

don

or

2010 2011 2012 2013 2014

69%79% 81%

84%

3758 consecutive initial searches

National PatientsActuarial probability of donor and transplantation (2013-2014)

45

Probability of donor and transplantation (2013-2014)(Acute leukemia and MDS)

0 3 6 9 12 15 18

Months since beginning of search

1

0,8

0,6

0,4

0,2

0

Act

uaria

l pro

babi

lity

918 consecutive initial searches

Donor located

Transplantation (BM + PB + CB)

Transplantation (BM or PB)

National PatientsUnrelated transplants

Stem-cell transplants carried out in 2014 ▼ 6% 452

Note: REDMO’s statistics for transplant activity do not necessarily match those of the NTO. This is due to the fact that occasionally, TCs cryopreserveparts of a donation with high cellularity. If this part of the donation is used later on, the TC views it as a second transplant, whereas for REDMO there’sonly been one donation. The opposite may also take place, that is, a second and immediate donation is carried out after a first donation with very lowcellularity, and although the TC will consider it one single transplant, for REDMO it would count as two separate transplants.

By product

Bone Marrow ▼ 4% 79

Peripheral Blood ▼ 5% 284

Umbilical Cord Blood ▼ 12% 89

Lymphocyte collection 16

46

12 29 43 45 60 65 51 53 50 43 43 30 50 48 55 78 83 96 90 81 795 2 7 11 9 26 36 46 5687 115 117

145179

228 247301 284

8 14 17 20 29 35 40 51 46 62

104116

137

133142

152 107101

89

BM PB CBU

National PatientsSearch requests and transplants per Authonomous Community of patient’s residence

47

0

20

40

60

80

100

0

20

40

60

80

100National Average = 46%

National Average = 73%

National Average = 59 %

% of searches started with suitable donor found x 100 000 inhabitants

% of searches started with transplant performed x 100 000 inhabitants

% of BM/PB trasnplants in patients with suitable donor found x 100 000 inhabitants

0

20

40

60

80

100

HospitalBone Marrow Peripheral Blood Umbilical Cord Blood Total TPHs

by hospital(2013)

Patientswithin the

AC

Patientsexternal to

the AC

Total per AC (2013)<=15 >15 <=15 >15 <=15 >15

H. Carlos Haya 6 2 1 9 (11) 9

79 (73)

H. de Jerez 7 7 (8) 7

H. Reina Sofía 1 6 13 20 (20) 19 1

H. Virgen de las Nieves 14 1 15 (5) 14 1

H. del Rocío 1 1 1 21 4 28 (29) 28

H. Central de Asturias 11 1 1 13 (10) 13 13 (10)

H. Son Espases 1 3 4 (1) 4 4 (1)

H. Marqués de Valdecilla 11 8 19 (19) 9 10 19 (19)

H. Clínico de Salamanca 1 25 1 27 (30) 22 5 27 (30)

CS Vall d’Hebron 11 3 3 20 7 5 49 (45) 36 13

123 (123)

H. Clínic i Provincial 2 25 1 28 (17) 19 9

H. de Sant Pau 1 2 3 10 6 5 27 (35) 20 7

H. Germans Trias i Pujol 1 5 3 9 (13) 9

H. Duran i Reynals 1 2 7 10 (13) 10

H. Ramón y Cajal 1 10 1 12 (16) 9 3

65 (77)

H. de la Princesa 2 14 16 (18) 13 3

H. Gregorio Marañón 1 4 4 9 (5) 8 1

H. La Paz 7 1 2 2 1 1 14 (15) 10 4

H. Niño Jesús 4 2 6 (12) 2 4

H. Univ. Puerta de Hierro 1 7 8 (11) 8

H. Morales Messeguer 2 2 (9) 28 (18)

H. Virgen de la Arrixaca 2 4 6 (9) 6

H. Clínico de Valencia 1 1 16 1 19 (14) 1957 (64)

H. La Fe 3 1 2 3 2 27 38 (50) 34 4

CHU A Coruña 5 5 (7) 5

28 (34)CHU de Santiago 2 2 1 4 9 (17) 9

CHU Vigo 1 12 1 14 (10) 14

H. de Navarra 3 3 (6) 3 3 (6)

H. Donostia 1 25 26 (28) 26 26 (28)

Total 29 50 23 261 26 63 452 387 65 452 (483)

Age range

National PatientsUnrelated transplants. By Autonomous Community

Transplants per Autonomous Community (2014) Summary of activity by Autonomous Community

49

Andalusia17%

Cantabria4%

Castile Leon6%

Catalonia 27%

Madrid14%

Murcia2%

Valencia13%

Galicia6%

Basque C.6%

Asturias3%

Balearic I.1%

Navarra1%

0

20

40

60

80

100

120

140

Total transplants Transplants within the Autonomous Community

National PatientsUnrelated transplants. By country of origin BM/PB

Germany (42%) 146

United States (19%) 65

Spain (12%) 42

United Kingdom 19

Portugal 18

Israel 16

France 15

Poland 13

Canada 6

Belgium 5

Italy 4

Denmark 2

Netherlands 2

Switzerland 2

Australia 1

Austria 1

Canada 1

Japan 1

Sweden 1

Taiwan 1

50

Germany40%

United States18%

Spain12%

United Kingdom5%

Portugal5%

Israel4%

France4%

Poland4%

Canada2%

Belgium1% Italy

1%

Brazil1%

Denmark1%

Netherlands1% Switzerland

1%Austria

0%Australia

0%

Canada0% Japan

0%Sweden

0% Taiwan0%

National patientsUnrelated transplants. By country of origin CBU

Spain (55%) 49

United States 16

France 10

Germany 6

Switzerland 3

Italy 2

Finland 1

Netherlands 1

United Kingdom 1

TPH CBU Activity - Spain(ratio children / adults)

51

Spain55%United States

18%

France11%

Germany7%

Switzerland4%

Italy2%

Finland1%

Netherlands1%

United Kingdom1%

0

20

40

60

80

100

120

Adults >=15 years old Childen <15 years old

DiagnosisDonor TPH

TPH CBUMO PB

Acute Myeloblastic Leukemia 13 80 38

Acute Lymphoblastic Leukemia 13 52 28

Myelodysplastic Disorders 7 44 8

Non-Hodgkin’s Lymphoma 2 37 2

Other Leukemias 2 14 1

Hodgkin’s Lymphoma 9

Severe Aplastic Anemia 19 6 2

Monoclonal Gammopathies 5 17 1

Chronic Myeloid Leukemia 1 7 3

Inherited Immune System Disorders 4 1 3

Inherited Erythrocyte Abnormalities 1 4 1

Other Malignancies 1 11

Histiocytosis 5

Other Non-Malignant Diseases 5 1

Inherited Metabolic Diseases 1 2 1

National patientsUnrelated transplants. Per diagnosis

52

Country Population TPH MO/PB MO/PB x 10^6 TPH CBU CBU x 10^6 Total TPH TPH x 10^6

Germany 80,5 2 319 28,8 7 0,1 2 326 28,9

Belgium 11,2 209 18,7 16 1,4 225 20,1

Japan 127,3 1 347 10,6 1 158 9,1 2 505 19,7

Netherlands 16,8 265 15,8 64 3,8 329 19,6

Israel 8,1 132 16,3 18 2,2 150 18,5

Sweden 9,6 170 17,7 2 0,2 172 17,9

France 63,9 886 13,9 196 3,1 1 082 17,0

United Kingdom 63,7 952 14,9 106 1,7 1 058 16,6

Austria 8,5 113 13,2 23 2,7 136 15,9

United States 317,7 4 117 12,9 913 2,9 5 030 15,8

Czech Republic 10,5 161 15,3 5 0,5 166 15,8

Switzerland 8,1 113 13,9 6 0,7 119 14,6

Italy 59,9 699 11,7 55 0,9 754 12,6

Australia 23,1 227 9,8 52 2,2 279 12,0

Canada 35,3 338 9,6 51 1,4 289 11,0

Korea 50,0 480 9,6 38 0,8 518 10,4

Spain 2013 47,3 382 8,1 101 2,1 483 10,2

Spain 2014 46,8 363 7,7 89 1,9 452 9,6

Poland 38,5 319 8,3 2 0,0 321 8,3

Brazil 201,0 177 0,9 36 0,2 213 1,1

China 1 354,0 715 0,5 366 0,3 1 081 0,8

* = TPH activity: WMDA report 2013 / World Population: Wikipedia

National PatientsUnrelated transplants by population* (2013)

53

National patientsUnrelated transplants. Evolution by population (2009-2013)

54

21,9

25

27,9 28,1 28,9

12,9

15,6

18,8 18,920,1

15,917,2

16 15,517

13,5 13,7 14,3 15,216,6

11,412,6 12,4 12,9 12,6

7,5 8,510,3 9,5 10,2 9,6

2009 2010 2011 2012 2013 2014

Germany Belgium France United Kingdom Italy Spain

REDMOTransplants coordinated by REDMO (1 of 2)

55

0

500

1000

1500

2000

2500

3000

3500

1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

BM (n= 1 292) PB (n= 2 126) LYM (n= 119) CBU (n=3 221)

BM / PB / CBU / LYM DONORSNational International Total

PatientsNational 959 3 641 4 600

International 2 158 2 158Total 3 117 3 641 6 758

REDMOTransplants coordinated by REDMO (2 of 2)

56

C/ Muntaner, 383, 2nd

08021 – Barcelona

Phone 93 414 55 66 Fax. 93 414 00 28

www.fcarreras.org