Training Course on

Medical Applications and Utilization of Cyclotron and RIs

▣ Duration : October 14 ~ November 3, 2004

▣ Venue : Seoul, Korea

▣ Number of Participants : 16 persons from 10 countries

▣ Training Institute : Korea Institute of Radiological & Medical

Sciences (KIRAMS)

Korea International Cooperation Agency(KOICA)

Korea Institute of Radiological and Medical Sciences(KIRAMS)

< CONTENTS >

I. GENERAL INFORMATION…………………………………….

II. BACKGROUND…………………………………………….…….

III. FRAMEWORK OF THE COURSE…………………………….

IV. COUNTRY REPORT……………………………………………..

V. ORIENTATION & EXTRA-CURRICULAR ACTIVITIES….

VI. INFORMATION…………………………………………………..

VII. TENTATIVE SCHEDULE……………………………………….

I . GENERAL INFORMATION

▣ Name : Medical Applications and Utilization of Cyclotron and RIs

▣ Duration : October 14 ~ November 3

▣ Venue : Seoul, Korea

▣ Number of Participants : 16 persons from 10 countries

▣ Training Institute : Korea Institute of Radiological and Medical Sciences

(KIRAMS)

▣ Qualifications for Applicants

Participants should:

― be nuclear medicine physicians with minimum 3 years’ clinical

research experience

― have sufficient command of both spoken and written English

― not have ever participated in KOICA’s training program before

II . BACKGROUND

Early detection of diseases is very important not only for early treatment but

also reduction of social medical costs. Nuclear medicine is making astonishing

progress with the development of imaging technologies in recent decades.

PET(Positron Emission Tomography) has already emerged as a very important

diagnostic tool for staging disease, evaluating the effect of treatments, and long-

term follow-up of cancer patients in many countries. It enables very early

detection of the recurrence that can lead the patients to effective treatment.

There is no doubt that PET utilization will be one of the major axes for the

future development of nuclear medicine. Furthermore, with elucidation of the

molecular mechanisms of diseases, the molecular imaging using PET

instruments will play an important role for diagnosis and treatment of various

diseases including malignant diseases.

Though clinical PET practice is far from the daily clinical use because of the

lack of experts, equipments, and budget in many developing countries,

however, it is expected that PET will be more widely introduced into RCA

Member States in the near future.

This course is designed to provide medical doctors with chances to gain a

general overview on the recent development of nuclear medicine and medical

applications of radioisotopes including clinical PET and SPECT(Single Photon

Emission Computed Tomography) utilization and RI therapy.

III . FRAMEWORK OF THE COURSE

A. Objectives

This course is designed to enable the participants

― to understand the PET, brain SPECT and relevant clinical imaging

technologies, and practice in nuclear medicine.

― to learn radioisotope production and cyclotron technologies

― to enhance scientific activities and to encourage research

collaboration in the field of nuclear medicine, particularly PET technology.

B. Course Contents

1. Radioisotope production and application of cyclotron technology

a. Nuclear Reactor

b. Accelerator RI Production

2. Radiopharmaceutical and cyclotron radiochemistry

a. PET radiopharmaceutical (overview, chemistry)

b. PET autosynthesis equipment (FDG, FET, FLT, MET, FBPA)

c. PET GMP/QC

d. Compounding, RDRC, regulation

e. Cyclotron performance : comparison local with import

f. Tour of KIRAMS cyclotron facility

3. Principle of PET technology

a. PET imaging system : Data analysis, reconstruction,

attenuation correction

b. Methodology, imaging protocol in KIRAMS, dynamic PET

c. Cost effectiveness of PET

d. RT planning using PET

e. Micro PET

4. Application of PET in clinical practice and practice with expert

a. PET in clinical oncology

b. PET in clinical research

c. Application of PET in neurology, cardiovascular system

5. Principles in molecular imaging

a. Angigenesis

b. Stem cell

c. Application in molecular imaging

6. Principles and practice in therapy using radioisotope

a. Current trend of radionuclide therapy

: Thyroid cancer, I-131 MIBG, Re-188 lipiodol, Ho-166 Tx

b. Monoclonal Ab Tx in lymphoma

c. Intracoronary Radiation Tx using Re-188

7. Practice with experts in myocardial and brain SPECT

8. Related topics

a. Dosimetry(MIRD), neuroreceptice imaging emergency radiation

medicine

C. Study Visit

● Seoul National University Medical Center

Seoul National University Hospital (SNUH) has served from the time modern

medicine was first introduced to the nation in 1885. Educationally, it offers

clinical education for college and graduate students of medicine, dentistry,

nursing and pharmacy, and also provides training for practicing physicians and

surgeons professional personnel and administrative staff. SNUH’s dual purpose

and goal is to raise scholars able to meet national requirements as well as to

create highly-trained individuals dedicated to the community.

Research has focused on the pathophysiology, diagnosis nad treatment of

diseases, especially cancer and genetic diseases, in cooperation with various

internationally prominent medical centers.

The hospital also emerges in collaborative researches with scholars of the basic

sciences in the Colleges of Medicine, Dentistry and Pharmacy through the

Clinical Research Institute and the Animal Experiment Laboratory.

As a tertiary hospital, SNUH provides the highest standards of patient care

available; the specialists make use of the latest state-of-the-art medical

technology to help the numerous patients referred to SNUH by primary and

secondary hospitals throughout the country. The hospital has striven to provide

a quicker, more organized approach to treatment through special clinics and the

on-going construction of the Clinical Research Institute and Bundang Hospital.

SNUH is working toward the goal of a “disease-free society” and will continue

its efforts to become a leading international hospital dedicated to the

improvement of health both in Korea and throughout the world.

● Asan Medical Center

Asan Medical Center(AMC), the principal hospital for seven local hospitals

located in rural areas, is a relatively young hospital that was inaugurated in June

23, 1989. At present, more than 1,000 doctors in thirty eight departments at the

Asan Medical Center provide high quality medical services in their specialized

fields. Several renowned clinical centers-Gastroenterology, Diseases Center,

Neurosciences Center, Heart Center Vascular Center, Health Promotion

Center(including Sports Medicine), Organ Transplantation Center, and Day

Surgery conduct exclusive health care services to those who need such care. In

addition, over 40 outpatient clinics offer the best medical services to patients in

every specialty area.

Recognizing the importance of research, the Asan Institute for Life Sciences, an

affiliated research institution of Asan Medical Center, conducts research in

numerous areas, AMC performs a leading role in medical and health education

by introducing pre-internship for medical students and nurses.

The newly introduced hospital re-engineering system for clinical activities and

for general management since August 1981 enables to strengthen the existing

patient-oriented hospital system to be more effective.

AMC’s effort to create a new patient-oriented hospital was also rewarded when

AMC received the first prize for Corporate Culture from the government in

1995. This was the first time the prize was awarded to the Korean medical

institution. The Customer Satisfaction Award in the hospital section in 1998,

and the Grand Prize for the Customer Satisfaction Award the following year

proved the excellence as well as the dedication of the hospital management.

Asan Medical Center’s 4,800 employees are dedicated to another goal: to create

a world-renowned hospital where a new and fresh hospital culture is created and

total dedication to patient-care is practiced.

D. Discussion and Presentation

1. Nuclear medicine Issue Discussion

2. Presentation of Country Reports by the Participants

3. Pre and Post Evaluation

IV . COUNTRY REPORT

This training course requires all the participants to prepare a “Nuclear Medicine

Country Report”, which will be presented at Country Report Session. Each

participant is recommended to make a 20~25 minute presentation on Nuclear

Medicine issues of his/her country. For more effective presentations, useful

learning instruments such as a beam projector, a overhead projector, and

multimedia TV will be equipped for participants. The PowerPoint type’s

presentation is preferred. The format of Country Report should be either of

PowerPoint or MS-Word, written in English, and be submitted to the Training

Coordinator on the first day at the KOICA International Cooperation Training

Center. The trainees from the same country are recommended to work together

in presenting Country Report. The report should be a computer printout or

typewritten on A4 sized paper. It would be much appreciated if the report is

available on a floppy diskette or a compact disk. The participants should

prepare OHP films or additional materials beforehand.

The participants are encouraged to load the following issues on their Country

Reports:

A. Self-Introduction

1. Brief introduction to your organization

2. Position and duties in your organization

3. Expected outcomes of this training course

B. Information regarding the project that you took/take part in

1. Introduction to the project

2. Target of the development

3. Major feature/achievement

C. Information on Nuclear Medicine Technology Management

1. Country’s policy on Nuclear Medicine

- Industrial policy, major government-supported programs, and long-term

development plan, related administrative bodies and their functions

2. Development stage of Nuclear Medicine field

3. Urgent problems to be solved and important Nuclear Medicine

projects in your country

4. Possibility of Nuclear Medicine cooperation in Nuclear Medicine

with Korea

5. Foreign investment environment

V . ORIENTATION & EXTRA-CURRICULAR ACTIVITIES

A. Orientation Programs

1. KOICA Orientation

To provide participants with better understanding of Korea and the way of life,

KOICA conducts a general orientation at ICTC(International Cooperation

Training Center) for 2 days prior to the actual training program at KIRAMS.

2. KIRAMS Orientation

KIRAMS will conduct an orientation on the course at the beginning of the

training program. It includes:

a. Opening Ceremony

b. Introduction to KIRAMS

c. Registration

B. Social & Cultural Program

1. Home-Visiting

During the course, each participant will have a chance to visit a Korean home

and spend several hours with the family as well as have dinner together.

2. City Tour of Seoul

Participants will be invited to a city tour of Seoul, which is both the capital and

the heart of the Republic of Korea. Seoul is the financial, political, commercial,

recreational, educational and cultural center of Korea. During this whole day

trip, participants will visit major attractions of Seoul such as ancient palaces and

traditional markets.

3. Field Trip and Cultural Experiences

Participants will be given opportunities to look around the well known

industrial complexes as well as historic places with ancient remains in Korea as

follows: Samsung Electronics Co., LG Information & Communications Co.,

POSCO, Hyundai Motors Co., and Gyeongju Historic areas.

▌Field Trip▐

a. POSCO

POSCO has been the most competitive steel company since its establishment in

1968, and keeps growing and evolving as a global company. It produces 26

million tons of steel products each year, enough to produce about 100,000

compact cars a day. With the goal of being the first company to bring changes to

the industrial paradigm, POSCO focuses on four goals : Top Quality & World

Wide Best Technology, Customer Service Improvement and Optional Growth &

Management System Innovation. A commitment to focused R&D investment,

cutting-edge research and world-class technical support is why POSCO is today

an international steel maker supplying developing countries with advanced

technology.

b. Hyundai Motor Co.

Hyundai Motor Company was established in December 1967. In the early 1980,

fueled by the rapid economic growth, Hyundai invested in a major expansion of

its Ulsan plant, making a major transition from low volume to high

manufacturing. During the latter 1980s, the company prepared itself for the

more intense competition that the 1990s would bring. Hyundai Motor Company

endured a difficult year in 1998, as domestic sharply declined. It was also a

period of company-wise and industry-wise restructuring. The Kia/Asia Motor

acquisition will allow Hyundai Motor to achieve economy of scale needed to

compete in the global market.

c. Korea Atomic Energy Research Institute

Since its inception in 1959, KAERI has made rapid growth in research

expansion and diversity, new technical development, and strengthened

competitiveness in the domestic and international arenas.

Nuclear basic research provides the foundation to achieve self-reliance in

nuclear technology in the 2000s by applying future-oriented state-of-the-art

technologies to the existing technologies to the existing technologies. KAERI

puts great emphasis on the development of state-of-the-art technologies for

future applications, such as laser technology, artificial intelligence, robotics,

new nuclear materials, radiochemistry, radio-environment, and nuclear fusion.

Laser technologies are applied to remote metrology, surface treatment,

precision processing, and decommissioning; a radiation-resistant robot

improves the safety of operators working in nuclear power plants; new

materials improve the endurance and quality of the power plant structure; radio-

chemistry promotes the radioactive waste management technology; radio-

environmental research analyzes and evaluates the effect of radiation; artificial

intelligence is widely utilized to improve the I&C technology in nuclear power

plant.

Also, KAERI has great interest in developing a nuclear fusion facility and has

been actively involved in the international collaboration program.

d. Gyeongju Historic Site

Gyeongju City and its surroundings fall heir to traces of the glory that flowered

then withered in the ancient Shilla Kingdom from 57 BC to 935 AD. The

downtown area and the suburbs contain many royal burial mounds and

Buddhist remains which preserve that aesthetic zenith of Shilla art and culture.

Bulguksa Temple and Seoggulam are perhaps the most well known of

Gyeongju’s treasure. Built by Dae-Seong Kim and begun in 751 AD, the 10th

year of the region of King Gyeongdeok in memory of his parents, Bulguksa

Temple and Seokgulam Grotto were completed over a span of thirty years. Both

were designated as World Cultural Heritage sites by UNESCO on December 6,

1995.

VI . INFORMATION

A. Training Institute

1. KOICA

The Korea International Cooperation Agency (KOICA) was established in April

1991 under the Ministry of Foreign Affairs and Trade as a government agency.

KOICA implements a variety of programs, including training programs,

dispatch of volunteers, experts and medical doctors, project-type cooperation,

provision of equipment, and development study.

Through these programs, KOICA strives to share lessons and experience

learned in the process of economic development that can be referred by

developing countries and to promote friendly and cooperative relations with

developing partners.

KOICA will continue to support developing countries under the principles of

the MOFAT and contribute to the promotion of world peace and prosperity

under the motto “Cooperation for a Better World.”

2. KIRAMS

Korea Institute of Radiological and Medical Sciences (KIRAMS) is a

government-affiliated, medical and radiological sciences complex. The institute

takes its leading roles in performing cancer treatment and research on medical

application of radiation.

Specialized in cancer treatment, since 1963, KIRAMS has annually served 5 to

10 % of cancer patients in the nation. KIRAMS is equipped with cutting-edge

technologies such as PETs and Cyclotrons. In 2002, KIRAMS successfully

developed 13-MeV cyclotron by its own technology. In order to exchange

significant knowledge for improving quality of human health, KIRAMS is

strengthening network with relevant organizations all over the world.

B. Others

1. Regulation

Participants should:

a. follow the training program to the best of their ability and abide by rules of

the university, college, or institution in which participants undertake

training,

b. refrain from engaging in political activities, or any form of

employment for profit or gain,

c. return to their home country upon completion of the training program and

resume work in their county,

d. not extend the length of the training program or their stay for personal

convenience,

e. not bring any family members(dependents) to Korea or to the country of

training,

f. accept that the Korean government is not liable for any damage or losses of

their personal property,

g. accept that the Korean government will not assume any responsibility for

illness, injury or death arising from extracurricular activities, willful

misconduct of undisclosed pre-existing medical condition,

h. carry out such instructions and abide by such conditions as may be stipulated

by the Korean government in respect to the training program.

2. Expenses

Korea International Cooperation Agency(KOICA) will bear the expenses

related to the implementation of the course, incurred during the training in

accordance with relevant laws and regulations.

The expenses include:

a. A normal economy class round-trip air ticket between Seoul and

international airport designated by KOICA

b. Room & board from arrival to departure from Korea

c. Daily allowance for incidental expenses

d. Medical insurance for participants to cover medical treatment during

their stay in Korea(Costs related to pre-existing illness, pregnancy and

dental treatment are not included.).

※ Note : Each participant is advised to maintain some pocket money of their

own for incidental expenses that might be incurred during his or her trip to

Korea, prior to receiving their allowance.

3. Language

The training course will be conducted entirely in English without any

interpreters.

4. Certificate

The certificate of completion will be awarded to all the participants who

successfully complete the course.

5. Contact Information

ICTC(International Cooperation Training Center), KOICA

- Address : 304 Yeomgok-Dong, Seocho-Gu, Seoul 137-170, Korea

- Tel. : +82-2-3460-5823

- Fax : +82-2-3460-5920

- Homepage : http://www.koica.go.kr

- Program Officer : Taek-Keun Lee (tknlee@koica.go.kr)

Korea Institute of Radiological & Medical Sciences (KIRAMS)

- Address : 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706, Korea

- Tel : +82-2-970-2059

- Fax : +82-2-970-2419

- Homepage : http://www.kirams.re.kr

- Coordinator : Choon-Seong Lee (csl@kcch.re.kr)

Medical Applications and Utilization of Cyclotrons and RIs

Duration October 14 ~ November 3, 2004 (21 days)

Participants 16

Objectives

- To distribute cutting-edge nuclear medicine technologies to

developing countries

Contents

- Overview on nuclear medicine and clinical applications of PET

(Positron Emission Tomography)

- Production and clinical applications of short-lived radioisotopes in

nuclear medicine

- Medical applications of cyclotron

- Current trends in nuclear medicine

Qualifications for Applicants

Participants should:

- Be nuclear medicine physicians with minimum 3 years’ clinical or

research experience;

- Have sufficient command of both spoken and written English;

- Be in good health, both physically and mentally, to undergo the course

- Expect to work in the related area for at least one year after the

completion of this program;

- Not have any experience of previous participation in KOICA’s training

program or any other similar program; or

- At least 5 years should have elapsed from their previous participation

in KOICA’s training program.

Training Institute

Korea Institute of Radiological and Medical Sciences (KIRAMS)

- KIRAMS is a government-affiliated, medical and radiological sciences

complex. The institute takes its leading role in performing cancer

treatment and research on medical applications of radiation and

radioisotopes. KIRAMS is equipped with cutting-edge technologies

such as PET, and medical cyclotrons. In 2002, KIRAMS successfully

developed 13 MeV cyclotron using its own technology.

- In order to exchange significant knowledge for improving the overall

quality of human health, KIRAMS is strengthening its network with

relevant organizations all over the world.

- Address: 215-4 Nowon-Ku, Kongneung-Dong, Seoul, Korea 139-706

- Tel: 82-2-970-2059

- Fax: 82-2-970-2419

- Website: http://www.kirams.re.kr

- E-mail: csl@kcch.re.kr (Coordinator: Mr. Choon-Seong Lee)

Closing Date for Application August 14, 2004

VII . TENTATIVE SCHEDULE

Date Activities Remark

s

Oct. 14~17 Arrival and Orientation at KOICA

Oct. 18

(Mon)

Arrival and Registration at KIRAMS

Inauguration

Pre-course evaluation

Oct. 19

(Tue)

Production of PET radiopharmaceuticals

PET radiopharmaceuticals

Physics and instruments in PET

Whole body PET and PET/CT imaging

methods

Oct. 20

(Wed)

Artifact and normal variant in PET imaging

PET imaging in brain tumors

PET imaging in head and neck cancer

Oct. 21

(Thu)

PET imaging in lung cancer

PET imaging in breast cancer

PET imaging in esophageal and gastric cancer

Oct. 22

(Fri)

PET imaging in lymphoma

PET imaging in gynecologic cancer

Oct. 23

(Sat)

City tour

Oct. 24

(Sun)

City tour

Oct. 25

(Mon)

PET imaging in tumors of the pancreas and liver

PET imaging in colorectal cancer

PET imaging in genitourinary cancer

PET imaging in bone and soft tissue sarcoma

Oct. 26

(Tue)

PET imaging in rare melanoma and rare

malignancies (tumors of ophthalmic site and

skin)

PET imaging in thyroid cancer

PET studies of neurochemical system

PET imaging in seizure disorder,

dementia, cerebrovascular disorder

Oct. 27

(Wed)

PET imaging in movement disorder and

psychiatric disorder

Assessment of myocardial perfusion and

viability by PET

Oct. 28

(Thu)Industrial field tripOct. 29

(Fri)

Oct. 30

(Sat)

Oct. 31

(Sun)

No official schedule

Nov. 1

(Mon)

Complementary lectures

Nov. 2

(Tue)

Post-course evaluation

Nov. 3

(Wed)

Departure

Medical Applications and Utilization of Cyclotrons and RIs

Duration October 14 ~ November 3, 2004 (21 days)

Participants 16

Objectives

- To distribute cutting-edge nuclear medicine technologies to

developing countries

Contents

- Overview on nuclear medicine and clinical applications of PET

(Positron Emission Tomography)

- Production and clinical applications of short-lived radioisotopes in

nuclear medicine

- Medical applications of cyclotron

- Current trends in nuclear medicine

Qualifications for Applicants

Participants should:

- Be nuclear medicine physicians with minimum 3 years’ clinical or

research experience;

- Have sufficient command of both spoken and written English;

- Be in good health, both physically and mentally, to undergo the course

- Expect to work in the related area for at least one year after the

completion of this program;

- Not have any experience of previous participation in KOICA’s training

program or any other similar program; or

- At least 5 years should have elapsed from their previous participation

in KOICA’s training program.

Training Institute

Korea Institute of Radiological and Medical Sciences (KIRAMS)

- KIRAMS is a government-affiliated, medical and radiological sciences

complex. The institute takes its leading role in performing cancer

treatment and research on medical applications of radiation and

radioisotopes. KIRAMS is equipped with cutting-edge technologies

such as PET, and medical cyclotrons. In 2002, KIRAMS successfully

developed 13 MeV cyclotron using its own technology.

- In order to exchange significant knowledge for improving the overall

quality of human health, KIRAMS is strengthening its network with

relevant organizations all over the world.

- Address: 215-4 Nowon-Ku, Kongneung-Dong, Seoul, Korea 139-706

- Tel: 82-2-970-2059

- Fax: 82-2-970-2419

- Website: http://www.kirams.re.kr

- E-mail: csl@kcch.re.kr (Coordinator: Mr. Choon-Seong Lee)

Closing Date for Application August 14, 2004