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8/20/2019 9. YL Kegawatdaruratan Pediatric.pptx
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PEDIATRIC
EMERGENCY Silvia TriratnaDivisi Pediatri Gawat Darurat
Bagian Ilmu Kesehatan Anak FK UNSRIPalembang
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• RSPIRAT!R" #RGN$"
• $IR$U%AT!R" #RGN$"
• NUR!G" #RGN$"• ND!$RIN #RGN$"
• TRAU#A
• P!IS!NING& INT!'I$ATI!N• (((((((
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• A )undamental *+n*e,t in,ediatri* emergen*- *are is
that *hildren are n+t sim,l-s*aled.d+wn adults and*ann+t be treated as su*h(
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Pediatri* *+nsiderati+n
• A *hild/s ,h-si+l+gi* res,+nse t+ a*riti*al illness +r in0ur- is di1erent)r+m an adult/s((
• $hildren are als+ devel+,ingmentall- and behavi+rall-(
• In)ants and -+ung *hildren *ann+ttell -+u what the ,r+blem is +r whereit hurts(
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PEMERIKSAAN
SULIT DILAKUKAN
KOMINIKASI SULIT
C NDRUNG
K TAKUTAN
PENILAIAN KEGAWATAN
SULIT DILAKUKAN
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CHILD IS NOT SMALL ADULT
The ke- di1eren*es t+ *+nsiderin *hildren are23( 4eight5( Anat+mi*al 6 si7e and sha,e8( Ph-si+l+gi*al 6
*ardi+vas*ular9 res,irat+r-9
immune )un*ti+n:( Ps-*h+l+gi*al 6 intelle*tualabilit- and em+ti+nal res,+nse
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In)ant is nasal breather
• N+se is res,+nsible )+r ;res,irat+r- distress +r )ailure
S+S+metimes9 +ral and nasalsu*ti+ning is all that is
needed??
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Tongue
• %arge in ,r+,+rti+n t+ rest +) +ral *avit-
• %+ss +) t+ne with slee,9 sedati+n9 $NSd-s)un*ti+n
• Fre@uent *ause +) u,,er airwa- +bstru*ti+n
P+siti+ning with +r with+ut+ral airwa- *an be en+ugh(
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Pediatric Cardiopulmonary Arrest
Almost all pediatric “codes” are of respiratory origin
Internal Data. B.C. Children’s Hospital, ancou!er. "#$#.
10%10
%
80%
100%
75%
%ur!i!al rate
HentiNapas
HentiKa!iopu"#ona"
75 $ 0 %
7 $ 11 %
9
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KEHI&ANGANCAIRAN
PRDARAANG
%UKA BAKAR
MA&DI'TRI()'ICAIRAN
S"!K SPTIK PN"(ANTUNG
ANAFI%AKSIS
DI'TRE'PERNAPA'AN
ASPIRASIAS#A
BP
DEPRE'IPERNAPA'AN
KANG TIK ↑
KRA$UNAN
GAGA% SIRKU%ASI GAGA% NAPAS
GAGA& KARDI*P)&M*NA&
HENTI +ANT)NG
Pen,e-a- Kega.atan Ka!iopu"#ona"
10
Pediatric&CP'((((((
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'PIRAT*RY EMERGEN
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The Need for Oxygen
0 – 1 minute: cardiac irritability 0 – 4 minutes: brain damage not likely 4 – 6 minutes: brain damage ossible 6 – 10 minutes: brain damage !ery likely " 10 minutes: irre!ersible brain damage
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Res,irat+r- mergen*ies
• In *hildren9 illness and in0ur-)re@uentl- result in res,irat+r-
*+m,r+mise9 a leading *ause +),ediatri* m+rbidit- and m+rtalit-C
• #anagement +) the airwa- and
breathing sh+uld be -+ur rst*+n*ern in all ,ediatri* ,atients
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Res,irat+r- mergen*ies
#esiratory distress is one of the mostcommon chief comlaints for $hichchildren seek medical care%
nearly 10 & of ediatric emergencydeartment !isits and '0 & ofhositali(ations
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#esiratory distress in children)articularly neonates and infants)must be romtly recogni(ed andaggressi!ely treated because theymay decomensate *uickly%
1+
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#esiratory arrest is the mostcommon cause of cardiac arrest inchildren and outcomes are oor foratients $ho de!elocardioulmonary arrest as the resultof resiratory deterioration
16
P di t i
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Pening/atan
penggunaan 'u-stat
*/sigenG"u/osa
Pu"ses
)ottled
Dingin
Pu2at
CRT
Respon3!oice,
pain4
Ge"isa
Irrita*l
e
Ke6ang
Ko#a
''PKu"itKa!ioas/u"
e
*ganA-!o#en
Gin6a"
+hirdspacing
uids
I"eus
Dysmotili ty
Bo-elslough
Anuria
liguri a
/rine
output 0
Gaga" 6antung
Resistensi /api"e
Ta/i/a!
i
(a!i/a!i
Asystol e
Pediatric&CP'((((((
Maniestasi /"inis
1,
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1-
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Pediatric considerations
The fre*uency of acute resiratoryfailure is higher in infants and youngchildren than in adults) for se!eralreasons%
19
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.actors that contribute to raidresiratory comromise in children
smaller air$ays)
increased metabolic demands)
decreased resiratory reser!es)
inade*uate comensatorymechanisms as comared to adults%
'0
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/xtrathoracic air$ay differences
The area extending from the nosethrough the nasoharynx)oroharynx) and larynx to thesubglottic region of the tracheaconstitutes the extrathoracic air$ay%
This area differs in ediatric !ersusadult atients
'1
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/xtrathoracic air$ay differences
Neonates and infants are obligatenasal breathers until the age of '6months because of the roximity ofthe eiglottis to the nasoharynx%
Nasal congestion can lead toclinically significant distress in thisage grou%
''
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/xtrathoracic air$ay differences
The air$ay is small this is one of therimary differences in infants andchildren younger than - years comared$ith older atients%
2nfants and young children ha!e a large
tongue that fills a small oroharynx% 2nfants and young children ha!e a
cehalic larynx% The larynx is oosite!ertebrae 34 in children !ersus 36,
in adults% '
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/xtrathoracic air$ay differences
The eiglottis is larger and morehori(ontal to the haryngeal $all inchildren than in adults%
The cehalic larynx and large eiglottis
can make laryngoscoy challenging%
'4
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/xtrathoracic air$ay differences
2nfants and young children ha!e a narro$subglottic area%
2n children) the subglottic area is coneshaed) $ith the narro$est area at thecricoid ring%
5 small amount of subglottic edema canlead to clinically significant narro$ing)increased airway resistance, andincreased work of breathing%
'+
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/xtrathoracic air$ay differences
5dolescents and adults ha!e a cylindricalair$ay that is narro$est at the glotticoening%
'6
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/xtrathoracic air$ay differences
2n slightly older children) adenoidal andtonsillar lymhoid tissue is rominent andcan contribute to air$ay obstruction%
ncorrected congenital anatomicabnormalities 7eg) cleft alate) 8ierre
#obin se*uence or ac*uiredabnormalities 7eg) subglottic stenosis)laryngomalaciatracheomalacia maycause insiratory obstruction
',
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2ntrathoracic air$ay differences
The intrathoracic air$ays and lunginclude the conducting air$ays andal!eoli) the interstitia) the leura) thelung lymhatics) and the ulmonarycirculation%
'-
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2ntrathoracic air$ay differences
The intrathoracic air$ays and lunginclude the conducting air$ays andal!eoli) the interstitia) the leura) thelung lymhatics) and the ulmonarycirculation%
'9
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2ntrathoracic air$ay differences
2nfants and young children ha!e fe$eral!eoli than do adults% The numberdramatically increases during childhood)
from aroximately '0 million at birth to00 million by - years of age%
The al!eolus is small% 5l!eolar si(eincreases from 1+01-0 to '+000 ;mduring childhood%
Therefore) infants and youngchildren ha!e a relati!ely small
area for gas exchange0
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3ollateral !entilation is not fullyde!eloed
therefore) atelectasis is more common
in children than in adults%
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The resiratory um includes
the ner!ous system $ith central control7ie) cerebrum) brainstem) sinal cord)
eriheral ner!es) resiratory muscles) and
chest $all%
Respiratory pump differences
'
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The resiratory center is immature ininfants and young children
leads to irregular resirations and anincreased risk of anea%
The ribs are hori(ontally oriented%=uring insiration) a decreased
!olume is dislaced)the caacity to increase tidal !olumeis limited comared $ith that in
older indi!iduals%
Respiratory pump differences
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The small surface area for theinteraction bet$een the diahragmand thorax limits dislacing !olume in
the !ertical direction%
The musculature is not fullyde!eloed% The slo$t$itch fatigue
resistant muscle fibers in the infantare underde!eloed%
Respiratory pump differences
4
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The soft comliant chest $all ro!ideslittle oosition to the deflatingtendency of the lungs%
This leads to a lo$er functionalresidual caacity in ediatric
atients than in adults) a !olumethat aroaches the ediatrical!eolus critical closing !olume%
Respiratory pump differences
+
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6
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3auses of acute resiratorycomromise in children
#esiratory tract
3ardio!ascular
Ner!ous system
>astointestinal
?etabolic and endocrine diseases
@ematology
8oisoning
2N./3T2ON) etc,
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3auses of acute resiratorycomromise in children
#esiratory tract
-
=ecrease muscle tone
2nfection
5sthma
5nahylaxis
.oreign body 7uer air$ay) lo$er air$ay) esohagus5ir$ay anomalies 7eg) laryngomalacia) laryngosasm)
tracheoesohageal fistula) tracheal stenosis) tracheal ring
Aiologic or chemical $eaons 7eg) anthrax) ner!e agents) ricin
3hest $all abnormalities 7eg) flail chest) oen neumothorax
Thoracic ca!ity conditions 7eg) neumothorax) hemothorax) leuraleffusion) emyema) mediastinal mass
8ulmonary contusion
8ulmonary embolism
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3auses of acute resiratorycomromise in children
Respiratory tract
9
INFECTION
!ulitis)
/iglottitis#etroharyngeal abscess) 8eritonsillar
abscess3rouAacterial tracheitisAronchiolitis)
8neumonia
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3auses of acute resiratorycomromise in children
3ardio!ascular
40
Congenital heart disease
5cute decomensated heart failure
?yocarditis
8ericarditis
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3auses of acute resiratorycomromise in children
Ner!ous system
41
• Depressed entilation !eg, ingestion, CN"
tra#$a, sei%#res, or CN" infection&
• @yotonia 7!ariety of etiologies causing oor
air$ay or resiratory tone and ineffecti!eresiratory effort
• 8ulmonary asiration due to loss of air$ay
rotecti!e reflexes
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3auses of acute resiratorycomromise in children
'astrointestinal syste$
4'
"plinting fro$ abdo$inal pain!intraabdo$inal tra#$a&
5bdominal distention 7eg) small bo$elobstruction) bo$el erforation
>astroesohageal reflux $ith ulmonary
asiration
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3auses of acute resiratorycomromise in children
?etabolic and endocrine diseases
4
(etabolic acidosis !eg, diabetic ketoacidosis, seere
dehydration, sepsis, to)ic ingestions&
@yerthyroidism
@yothyroidism
@yerammonemia
@ematologic=ecreased O' carrying caacity 7eg) acute se!ere anemia fromhemolysis) methemoglobinemia) carbon monoxide oisoning
5cute chest syndrome 7atients $ith sickle cell disease
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3auses of uer and lo$erair$ay roblems in children
44
*pper+iway
ower+irway
-oth
• Trauma• 3rou• Aacterial
Tracheitis• 5bscess
• /iglotitis• Neck 2mBury
• 5sthma• Aronchiolitis• 8neumonia• Aruising of
the Cung
• 3ollaseCung
•
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#esiratory roblems ha!e le!els of se!erity
#esiratory distress)
#esiratory failure) and #esiratory arrest%
4+
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#esiratory /mergencies
E #esiratory distress is a state $here achild is able to maintain ade*uateoxygenation of the blood) but only by
increasing his or her $ork of breathing%
E #esiratory failure occurs $hen a child
cannot comensate for inade*uateoxygenation and the circulatory andresiratory systems begin to collase%
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#esiratory /mergencies
E #esiratory arrest
are unresonsi!e and lim) $ith cyanosisaround the lis%
#esiratory rate and $ork of breathingmay be !ery slo$ or absent) or you maynote agonal resiration
Dinfre*uent) gasing breaths $ith nochest rise
Da attern that is seen in dying
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#esiratory arrest
3hildren are unresonsi!e andlim) $ith cyanosis around the lis%
#esiratory rate and $ork ofbreathing may be !ery slo$ orabsent) or you may note agonal
resirationDinfre*uent) gasingbreaths $ith no chest rise
4-
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#esiratory arrest is the mostcommon cause of cardiac arrest inchildren and outcomes are oor for
atients $ho de!elocardioulmonary arrest as the resultof resiratory deterioration
49
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3linical e!aluation of#esiratory /mergency
.ow do yo# initially assess apatient in respiratory distress/
+0
should be rapid and 0#ickly deter$ineif atient needs emergent inter!entions
and rule out life threatening conditions
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P E N A M P
I & A N
) P A
Y A N
A 9 A '
'IRK)&A'I K)&IT
;3
T = Tonus
I =Interactiveness C = Consolability L = Look/Gaze S = Speech/Cry
Suara nafasabnormal
Posisi abnormal Retraksi apas cupin!
hi"un!
#ottle" Pucat Sianosi
s
'EGITIGA PENI&AIAN PEDIATRIK P$%I&TRIC &SS$SS#$T TRI&GL$ = P&T'
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• A)ter *+m,leting the Triangle9begin a m+re *+m,lete
• pediatric primary sur!ey (
AIRWAY
BREATHING
CIRCULATION
DISABILITY
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Tachynea: Eorld @ealthOrgani(ation
+ge -reaths per $in#te
Cess than ' months "60 breathsmin
' to 1' months "+0 breathsmin
1 to + years "40 breathsmin
?ore than + years "'0 breathsmin
#eroduced $ith ermission from: Eorld @ealth Organi(ation% The management of acute resiratory infections inchildren% 2n: 8ractical guidelines for outatient care% Eorld @ealth Organi(ation) >ene!a) 199+% 3oyright F199+ Eorld@ealth Organi(ation%
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=iagnostic studies for e!aluationof acute resiratory distress
-edside testing1 8ulse oximetry
2N=235T2ON:
5ll atients $ith resiratory distress
+4
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=iagnostic studies for e!aluationof acute resiratory distress
-edside testing1 8ulse oximetry
Normal !alues desite hyoxia seen in atients $ith se!ereanemia) carboxyhemoglobin) or sickle cell disease
.alsely lo$ !alues obtained in atients $ith ulse oximeter
not correlating $ith ulse) oor eriheral erfusion) !enouscongestion) methemoglobinemia) certain nail olish colors)and in atients recei!ing !ital dyes 7eg) methylene blueduring surgical rocedures
++
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=iagnostic studies for e!aluationof acute resiratory distress
Test Indications Co$$ents
-edside testing
/ndtidal
3O'7/T3O'
measurement
3onfirmation of
succesful endotracheal
intubationNonin!asi!e monitoring
of !entilation inintubated atients
Nonin!asi!e monitoringfor sedation in children
?easurable in nonintubated and
intubated) atients
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
-edside testing
/lectrocar
diogram
3linical susicion of
cardiac disease
7eg) cardiacmurmur) gallo)
differential ulsesor blood ressure
bet$een uer andlo$er extremities
Tyically combined $ith chestradiograh to assess heart si(e and
ulmonary !asculature in order todetermine need for echocardiograhy
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
aboratory testing
5rterial blood
gas
=etermine 8aO' for
calculation of
hysiologic measuresof oxygenation 7eg) 5
a gradient) 8aO'.iO'ratio
3orrelate 3O' $ithendtidal 3O'
measurments?easure @ and
correlate $ith !enous@
/ndtidal 3O') ulse oximetry)and !enous blood gases may be
used as less in!asi!e methodsfor ongoing monitoring of
oxygenation) !entilation) andacidbase status if they
correlate $ith arterial blood gasmeasurements
d f l
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
aboratory testing/lectrolytes
) blood urea
nitrogen)creatinine
8atients $ith
metabolic acidosis
5ssesses for the resence of
an anion ga and renaldysfunction
>lucose5ltered mental
status
5mmonia
5ltered mentalstatus and other
findings suggesti!e
of urea cycle
defects
d f l
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
aboratory testing
3arboxyhemoglobin
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
aboratory testing
=dimer
3linical findings
suggesti!e of
ulmonary embolus7eg) lo$ oxygenation)
leuritic chest ain)$edgeshaed
infiltrate on chestradiograh) and
redisosing conditionGeg) sickle cell
disease) thromboticconditionH
8ulmonary embolus is a rare
cause of resiratory distress in
children2maging otions in atients $ith
moderate to high clinicalrobability and ele!ated =
dimer include!entilationerfusion scan)
ultrasound of extremity !einsand dee !eins) 3T ulmonary
angiograhy) and ulmonaryangiograhy
=i ti t di f l ti
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
I$aging
Cateral neckradiograh
3linical findings
suggesti!e ofeiglottitismretroharyngealabscess or ingested
foreign body
3rou can usually bediagnosed clinically
$ithout a radiograh
3hest
radiograh
5ll children $ith
significantresiratory distress
and those $ith focal
lung findings
=i ti t di f l ti
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
I$aging.orced
exiratory or
bilateraldecubitus
chestradiograh
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=iagnostic studies for e!aluation
of acute resiratory distressTest Indications Co$$ents
I$aging
5bdominalradiograhs
7suine and
uright) orcrosstable
lateral
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3rou lateral neck radiograh
66Cateral neck radiograh sho$ing subglottic narro$ing and
distended hyoharynx consistent $ith acute laryngotracheitis%
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Aacterial tracheitis
6,
Cateral neck radiograh sho$ing intraluminal membranes and tracheal $allirregularity consistent $ith bacterial tracheitis%3ourtesy of #% 8aul >uillerman) ?=) =eartment of #adiology) Aaylor 3ollege of?edicine%
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#etroharyngealabscess
6-
Cateral neck radiograh demonstrating $idening of the retroharyngeal sace and re!ersal of thenormal cer!ical sine cur!ature% The retroharyngeal sace is considered $idened if it is greater than, mm at 3' or 14 mm at 36% The eiglottis and subglottic area in this radiograh are normal%
3ourtesy of Koe Alack) =eartment of =iagnostic 2maging) Texas 3hildrenJs @osital%
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>/N/#5C 5
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,0
52#E5L 5
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52#E5L 5
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5ir$ay and Areathing?anagement
8ositioning is the first ste in air$aymanagement%
2nfants : should be laced in the
Isniffing ositionI by a head tilt3hinlift or Ba$thrust maneu!er thatbrings the angle of the chin u 90
degrees from the bed
,'
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5ir$ay Obstruction
3rou 5 !iral infection of the air$ay belo$
the le!el of the !ocal cords
/iglottitis 2nfection of the soft tissue in the
area abo!e the !ocal cords
.oreign body air$ay obstructions
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3rou
is a common !iral infection that usuallyaffects children ' to 4 years old%
affects the larynx and trachea) although
this illness may also extend to thebronchi%
-+& of children to ha!e mild crou)
less than 1& $ith se!ere crou%
,4
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3rou
Tyical signs include a lo$grade fe!erof -M3 to 9M3)
a sealbark cough) and stridor)
articularly if the child is agitated% onset is gradual%
Areathing roblems $orsen at night) and
may aear se!ere and extremelyusetting to caregi!ers%
,+
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/iglottitis
5 bacterial infection that usually affectschildren 4 to 6 years old
usually resents $ith a higher fe!er rangingfrom 9M3 to 40M3%
=ifficulty s$allo$ing may cause the child todrool%
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Aacterial tracheitis
This bacterial infection causes thetrachea to s$ell)
resulting in artial air$ay obstruction%
@igh fe!er)
lo$itched stridor 7a snoring sound
a roducti!e cough are usually
resent
-0
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&'
Questions ?
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-
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-4
$+ngenital an+malies ass+*iated with strid+r
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gMa"o#ation Caa2teisti2s
N+se Nasal de)+rmities$h+anal atresia +r agenesis9 se,tum de)+rmities9 turbinateh-,ertr+,h-9 vestibular atresia +r sten+sis(
Phar-n
$rani+)a*ialan+malies
An+malies *ausing )a*ial retrusi+n are ass+*iated with u,,erairwa- +bstru*ti+n9 in*luding $r+u7+nHs9 Pierre R+bin9 and A,ertHsS-ndr+me(
T+ngue #a*r+gl+ssia and gl+ss+,t+sis
%ar-n
%ar-ng+mala*ia#+st *+mm+n *ause +) *hr+ni* strid+r in in)ants( Alm+st all,atients ,resent b- J weeks +) age( S-m,t+ms are m+re,r+n+un*ed a)ter u,,er res,irat+r- in)e*ti+ns(
%ar-ngeal webs; ,er*ent l+*ated in the gl+tti* area( $+m,lete webs *auseres,irat+r- distress at birth9 ,artial webs ,r+du*e strid+r9 weak*r- and di1erent degrees +) res,irat+r- distress(
%ar-ngeal *-sts%+*ated in su,ragl+tti* area ma- *ause res,irat+r- distress andstrid+r(
Subgl+tti*hemangi+ma
Presents as ,r+gressive l+ud strid+r with in*reased res,irat+r-distress( Ass+*iated with hemangi+mas in +ther ,arts +) theb+d-(
Subgl+tti* sten+sis#a- be *+ngenital but m+re +)ten a*@uired se*+ndar- t+intubati+n( Usuall- l+*ated 5. 8 mm bel+w the gl+ttis(
Tra*he
a
Tra*heal sten+sisUsuall- ,resent with strid+r +r b+th strid+r and whee7ing( I)sten+sis is signi*ant9 res,irat+r- distress +**urs(
Las*ular rings +rslings
: ,er*ent +) vas*ular rings are s-m,t+mati*(
Ass+*iated with +ther *+ngenital an+malies( #a- be se*+ndar-t+ a vas*ular rin +r * sts( 4+rsens with u er res irat+r
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=efinitions
-6
+c#te respiratory fail#re
• inability of the lung to meet themetabolic demands of the body%
• This can be from failure of tissue
oxygenation andor failure of 3O'homeostasis
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=efinitions
hyoxaemic resiratory failure:
8aO' ≤ +0 mm @g $hen
breathing room air
hyercanic resiratory failure:
8a3O'≥ +0 mm @g%
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Aasic resiratory hysiology
--
The maBor function of the lung is to get oxygen into thebody and carbon dioxide out
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!5$!5
body and carbon dioxide out
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90
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Oxygen in
=eends on
85O'
=iffusing caacity
8erfusion
entilationerfusion matching
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$arb+ndi+ide
4aterva,+ur
!-gen
Nitr+gen
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Oxygen in =eends on
85O
'
.2O' 853O' 5l!eolar ressure entilation
=iffusing caacityOksigen terusmenerus berdifusi dari udara dalam al!eoli ke dalam aliran darahdan karbon dioksida 73O' terus berdifusi dari darah ke dalam al!eoli% Dif#si
adalah ergerakan molekul dari area dengan konsentrasi tinggi ke areakonsentrasi rendah% =ifusi udara resirasi terBadi antara al!eolus denganmembrane kailer% 8erfusion:
8erfusi aru adalah gerakan darah mele$ati sirkulasi aru untuk dioksigenasi)dimana ada sirkulasi aru adalah darah deoksigenasi yang mengalir dalamarteri ulmonaris dari !entrikel kanan Bantung% entilationerfusion matching:
entilasi adalah roses keluar masuknya udara dari dan aruaru) Bumlahnyasekitar +00 ml
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3arbon dioxide out
Cargely deendent on al!eolar!entilation
5natomical deadsace constant buthysiological deadsace deends on!entilationerfusion matching
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3arbon dioxide out
#esiratory rate
Tidal !olume
entilationerfusion matching
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8athohysiology
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@yoxemia) defined as a decreasedle!el of oxygen in the blood
hyoxia) defined as a decreased le!el
of oxygen in the tissues%
%
9,
These ' conditions may be
closely related and may or maynot coexist) but they are notsynonymous
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3auses of @yoxemia
?ismatch bet$een al!eolar !entilation 7 andulmonary erfusion 7P
2ntraulmonary shunt
@yo!entilation
5bnormal diffusion of gases at the al!eolarcaillary interface
#eduction in insired oxygen concentration
2ncreased !enous desaturation $ith cardiacdysfunction lus one or more of the abo!e +factors
9-
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The most imortant abnormalities ingas exchange that lead to resiratoryfailure are
P mismatch)intraulmonary shunt) and
hyo!entilation
99
9 *:
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9I*:
;enti"ation.itout
peusion3!ea!spa2eenti"ationM
Di
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101
8erfusi Balan darah menuBu embuluh darah aru
=ifusi ergerakan oksigen dan karbon dioksida melintasi
membran kailer al!eoli
entilasi ertukaran udara dari rongga al!eoli dan
atmosfer
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;= ;=
3
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7
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7shunting
2ntraulmonary
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P mismatch:
Dead space entilation
5l!eoli that are normally !entilated butoorly erfused
+nato$ic dead space >as in the large conducting air$ays that does
not come in contact $ith the caillaries e%gharynx
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P mismatch:
Dead space entilation
8hysiologic dead sace
5l!eolar gas that does not e*uilibrate fully $ithcaillary blood
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Diff#sion abnor$ality:
Cess common
5bnormality of the al!eolar membrane or a
reduction in the number of caillariesresulting in a reduction in al!eolar surfacearea
3auses include: 5cute #esiratory =istress
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@yo!entilation
can be caused by disease at any of the anatomical sites
in!ol!ed in !entilation%
Arainstem inBury or disease mayresult in imaired functioning of theresiratory centre)
imaired functioning of theresiratory centre $hich suressedby deressant drugs
109
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Brainstem
S,inal*+rdNerve r++tAirwa-
Nerve
Neur+mus*ular 0un*ti+n
Res,irat+r-mus*le
%ung
Pleura
$hest
wall
es at .i2 !isease #a, 2ause enti"ato, !istu-an
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111
• The ner!e roots may be damaged by trauma or tumour• ner!e inBuries and neuroathies such as >uillain Aarre or
critical illness neuroathy may affect motor neuronssulying resiratory muscles
• Neuromuscular blockers or disease of the neuromuscular Bunction 7eg myasthenia gra!is may imair transmission of
ner!e imulses to resiratory muscles• Or the roblem may be in the muscle itself% #esiratory
muscle fatigue) disuse atrohy and malnutrition areimortant causes of resiratory muscle failure in the 23
• 5lternati!ely the roblem may be a roblem of increasedresistance to airflo$% .or examle due to obstruction of the
uer air$ay or bronchosasm• Or the roblem may be decreased comliance of the lung
itself) the leura or the chest $all%
#esiratory .ailure
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#esiratory .ailure
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#esiratory .ailure
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3linical
#esiratory comensation
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3linical
#esiratory comensation Tachynoea 5ccessory muscles
#ecesssion Nasal flaring
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3linical
#esiratory comensation
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3linical
#esiratory comensation
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3linical
5ltered mental state
=PaO2 3 PaCO2 acidosis> ? ?dilatation of cerebral resistance
esseles ICP? >
=isorientation @eadache
coma asterixis
ersonality changes
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3linical
#esiratorycomensation
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Caboratory Testing
5rterial blood gas8aO'
8a3O'
8@
3hest imaging3hest xray
3T sacn
ltrasound
#esiratory .ailure
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Caboratory Testing
Other tests@emoglobin
/lectrolytes) blood urea nitrogen) creatinine
3reatinine hoshokinase) aldolase/R>) echocardiogram
/lectromyograhy 7/?>
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8 l i t
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Pa!5 kPaM
A b s a t u r a t i + n F =
M
O<
8ulse oximetry
< f
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C *
I" CRITIC+ TO+C.IE5IN'
-OT. "*R5I5+ +ND+ F+5OR+-E
NE*ROO'ICO*TCO(E 7