9. YL Kegawatdaruratan Pediatric.pptx

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    PEDIATRIC

    EMERGENCY Silvia TriratnaDivisi Pediatri Gawat Darurat

    Bagian Ilmu Kesehatan Anak FK UNSRIPalembang

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    • RSPIRAT!R" #RGN$"

    • $IR$U%AT!R" #RGN$"

    • NUR!G" #RGN$"• ND!$RIN #RGN$"

    •  TRAU#A

    • P!IS!NING& INT!'I$ATI!N• (((((((

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    • A )undamental *+n*e,t in,ediatri* emergen*- *are is

    that *hildren are n+t sim,l-s*aled.d+wn adults and*ann+t be treated as su*h(

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    Pediatri* *+nsiderati+n

    • A *hild/s ,h-si+l+gi* res,+nse t+ a*riti*al illness +r in0ur- is di1erent)r+m an adult/s((

    • $hildren are als+ devel+,ingmentall- and behavi+rall-(

    • In)ants and -+ung *hildren *ann+ttell -+u what the ,r+blem is +r whereit hurts(

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    PEMERIKSAAN  

    SULIT DILAKUKAN

    KOMINIKASI SULIT

    C NDRUNG

    K TAKUTAN

    PENILAIAN KEGAWATAN

    SULIT DILAKUKAN

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    CHILD IS NOT SMALL ADULT

     The ke- di1eren*es t+ *+nsiderin *hildren are23( 4eight5( Anat+mi*al 6 si7e and sha,e8( Ph-si+l+gi*al 6

    *ardi+vas*ular9 res,irat+r-9

    immune )un*ti+n:( Ps-*h+l+gi*al 6 intelle*tualabilit- and em+ti+nal res,+nse

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    In)ant is nasal breather

    • N+se is res,+nsible )+r ;res,irat+r- distress +r )ailure

    S+S+metimes9 +ral and nasalsu*ti+ning is all that is

    needed??

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    Tongue

    • %arge in ,r+,+rti+n t+ rest +) +ral *avit-

    • %+ss +) t+ne with slee,9 sedati+n9 $NSd-s)un*ti+n

    • Fre@uent *ause +) u,,er airwa- +bstru*ti+n

    P+siti+ning with +r with+ut+ral airwa- *an be en+ugh(

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    Pediatric Cardiopulmonary Arrest 

     Almost all pediatric “codes” are of respiratory origin

    Internal Data. B.C. Children’s Hospital, ancou!er. "#$#.

    10%10

    %

    80%

    100%

    75%

    %ur!i!al rate

    HentiNapas

    HentiKa!iopu"#ona"

    75 $ 0 %

    7 $ 11 %

    9

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    KEHI&ANGANCAIRAN

    PRDARAANG

    %UKA BAKAR

    MA&DI'TRI()'ICAIRAN

    S"!K SPTIK PN"(ANTUNG

    ANAFI%AKSIS

    DI'TRE'PERNAPA'AN

    ASPIRASIAS#A

    BP

    DEPRE'IPERNAPA'AN

    KANG TIK ↑

    KRA$UNAN

    GAGA% SIRKU%ASI GAGA% NAPAS

    GAGA& KARDI*P)&M*NA&

    HENTI +ANT)NG

    Pen,e-a- Kega.atan Ka!iopu"#ona"

    10

    Pediatric&CP'((((((

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    'PIRAT*RY EMERGEN

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    The Need for Oxygen

    0 – 1 minute: cardiac irritability 0 – 4 minutes: brain damage not likely 4 – 6 minutes: brain damage ossible 6 – 10 minutes: brain damage !ery likely " 10 minutes: irre!ersible brain damage

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    Res,irat+r- mergen*ies

    • In *hildren9 illness and in0ur-)re@uentl- result in res,irat+r-

    *+m,r+mise9 a leading *ause +),ediatri* m+rbidit- and m+rtalit-C

    • #anagement +) the airwa- and

    breathing sh+uld be -+ur rst*+n*ern in all ,ediatri* ,atients

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    Res,irat+r- mergen*ies

    #esiratory distress is one of the mostcommon chief comlaints for $hichchildren seek medical care%

    nearly 10 & of ediatric emergencydeartment !isits and '0 & ofhositali(ations

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    #esiratory distress in children)articularly neonates and infants)must be romtly recogni(ed andaggressi!ely treated because theymay decomensate *uickly%

    1+

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    #esiratory arrest is the mostcommon cause of cardiac arrest inchildren and outcomes are oor foratients $ho de!elocardioulmonary arrest as the resultof resiratory deterioration

    16

    P di t i

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    Pening/atan

    penggunaan 'u-stat

    */sigenG"u/osa

    Pu"ses

    )ottled 

    Dingin

    Pu2at

    CRT

    Respon3!oice,

     pain4

    Ge"isa

    Irrita*l 

    e

    Ke6ang

    Ko#a

    ''PKu"itKa!ioas/u"

    e

    *ganA-!o#en

    Gin6a"

    +hirdspacing

    uids

    I"eus

    Dysmotili ty 

    Bo-elslough

     Anuria

    liguri a

    /rine

    output 0

    Gaga" 6antung

    Resistensi /api"e

    Ta/i/a!

    i

    (a!i/a!i

     Asystol e

    Pediatric&CP'((((((

    Maniestasi /"inis

    1,

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    1-

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    Pediatric considerations

    The fre*uency of acute resiratoryfailure is higher in infants and youngchildren than in adults) for se!eralreasons%

    19

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    .actors that contribute to raidresiratory comromise in children

    smaller air$ays)

    increased metabolic demands)

    decreased resiratory reser!es)

     inade*uate comensatorymechanisms as comared to adults%

    '0

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    /xtrathoracic air$ay differences

    The area extending from the nosethrough the nasoharynx)oroharynx) and larynx to thesubglottic region of the tracheaconstitutes the extrathoracic air$ay%

    This area differs in ediatric !ersusadult atients

    '1

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    /xtrathoracic air$ay differences

    Neonates and infants are obligatenasal breathers until the age of '6months because of the roximity ofthe eiglottis to the nasoharynx%

    Nasal congestion can lead toclinically significant distress in thisage grou%

    ''

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    /xtrathoracic air$ay differences

    The air$ay is small this is one of therimary differences in infants andchildren younger than - years comared$ith older atients%

    2nfants and young children ha!e a large

    tongue that fills a small oroharynx% 2nfants and young children ha!e a

    cehalic larynx% The larynx is oosite!ertebrae 34 in children !ersus 36,

    in adults% '

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    /xtrathoracic air$ay differences

    The eiglottis is larger and morehori(ontal to the haryngeal $all inchildren than in adults%

    The cehalic larynx and large eiglottis

    can make laryngoscoy challenging%

    '4

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    /xtrathoracic air$ay differences

    2nfants and young children ha!e a narro$subglottic area%

    2n children) the subglottic area is coneshaed) $ith the narro$est area at thecricoid ring%

    5 small amount of subglottic edema canlead to clinically significant narro$ing)increased airway resistance, andincreased work of breathing%

    '+

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    /xtrathoracic air$ay differences

    5dolescents and adults ha!e a cylindricalair$ay that is narro$est at the glotticoening%

    '6

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    /xtrathoracic air$ay differences

    2n slightly older children) adenoidal andtonsillar lymhoid tissue is rominent andcan contribute to air$ay obstruction%

    ncorrected congenital anatomicabnormalities 7eg) cleft alate) 8ierre

    #obin se*uence or ac*uiredabnormalities 7eg) subglottic stenosis)laryngomalaciatracheomalacia maycause insiratory obstruction

    ',

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    2ntrathoracic air$ay differences

    The intrathoracic air$ays and lunginclude the conducting air$ays andal!eoli) the interstitia) the leura) thelung lymhatics) and the ulmonarycirculation%

    '-

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    2ntrathoracic air$ay differences

    The intrathoracic air$ays and lunginclude the conducting air$ays andal!eoli) the interstitia) the leura) thelung lymhatics) and the ulmonarycirculation%

    '9

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    2ntrathoracic air$ay differences

    2nfants and young children ha!e fe$eral!eoli than do adults% The numberdramatically increases during childhood)

    from aroximately '0 million at birth to00 million by - years of age%

    The al!eolus is small% 5l!eolar si(eincreases from 1+01-0 to '+000 ;mduring childhood%

    Therefore) infants and youngchildren ha!e a relati!ely small

    area for gas exchange0

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    3ollateral !entilation is not fullyde!eloed

    therefore) atelectasis is more common

    in children than in adults%

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    The resiratory um includes

    the ner!ous system $ith central control7ie) cerebrum) brainstem) sinal cord)

    eriheral ner!es)  resiratory muscles) and

    chest $all%

    Respiratory pump differences

    '

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    The resiratory center is immature ininfants and young children

    leads to irregular resirations and anincreased risk of anea%

    The ribs are hori(ontally oriented%=uring insiration) a decreased

    !olume is dislaced)the caacity to increase tidal !olumeis limited comared $ith that in

    older indi!iduals%

    Respiratory pump differences

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    The small surface area for theinteraction bet$een the diahragmand thorax limits dislacing !olume in

    the !ertical direction%

    The musculature is not fullyde!eloed% The slo$t$itch fatigue

    resistant muscle fibers in the infantare underde!eloed%

    Respiratory pump differences

    4

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    The soft comliant chest $all ro!ideslittle oosition to the deflatingtendency of the lungs%

    This leads to a lo$er functionalresidual caacity in ediatric

    atients than in adults) a !olumethat aroaches the ediatrical!eolus critical closing !olume%

    Respiratory pump differences

    +

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    6

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    3auses of acute resiratorycomromise in children

    #esiratory tract

    3ardio!ascular

    Ner!ous system

    >astointestinal

    ?etabolic and endocrine diseases

    @ematology

    8oisoning

    2N./3T2ON) etc,

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    3auses of acute resiratorycomromise in children

    #esiratory tract

    -

    =ecrease muscle tone

    2nfection

    5sthma

    5nahylaxis

    .oreign body 7uer air$ay) lo$er air$ay) esohagus5ir$ay anomalies 7eg) laryngomalacia) laryngosasm)

    tracheoesohageal fistula) tracheal stenosis) tracheal ring

    Aiologic or chemical $eaons 7eg) anthrax) ner!e agents) ricin

    3hest $all abnormalities 7eg) flail chest) oen neumothorax

    Thoracic ca!ity conditions 7eg) neumothorax) hemothorax) leuraleffusion) emyema) mediastinal mass

    8ulmonary contusion

    8ulmonary embolism

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    3auses of acute resiratorycomromise in children

    Respiratory tract

    9

    INFECTION

    !ulitis)

    /iglottitis#etroharyngeal abscess) 8eritonsillar

    abscess3rouAacterial tracheitisAronchiolitis)

    8neumonia

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    3auses of acute resiratorycomromise in children

    3ardio!ascular

    40

    Congenital heart disease

    5cute decomensated heart failure

    ?yocarditis

    8ericarditis

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    3auses of acute resiratorycomromise in children

    Ner!ous system

    41

    • Depressed entilation !eg, ingestion, CN"

    tra#$a, sei%#res, or CN" infection&

    • @yotonia 7!ariety of etiologies causing oor

    air$ay or resiratory tone and ineffecti!eresiratory effort

    • 8ulmonary asiration due to loss of air$ay

    rotecti!e reflexes

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    3auses of acute resiratorycomromise in children

    'astrointestinal syste$

    4'

    "plinting fro$ abdo$inal pain!intraabdo$inal tra#$a&

    5bdominal distention 7eg) small bo$elobstruction) bo$el erforation

    >astroesohageal reflux $ith ulmonary

    asiration

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    3auses of acute resiratorycomromise in children

    ?etabolic and endocrine diseases

    4

    (etabolic acidosis !eg, diabetic ketoacidosis, seere

    dehydration, sepsis, to)ic ingestions&

    @yerthyroidism

    @yothyroidism

    @yerammonemia

    @ematologic=ecreased O' carrying caacity 7eg) acute se!ere anemia fromhemolysis) methemoglobinemia) carbon monoxide oisoning

    5cute chest syndrome 7atients $ith sickle cell disease

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    3auses of uer and lo$erair$ay roblems in children

    44

    *pper+iway

    ower+irway

    -oth

    • Trauma• 3rou• Aacterial

    Tracheitis• 5bscess

    • /iglotitis• Neck 2mBury

    • 5sthma• Aronchiolitis• 8neumonia• Aruising of

    the Cung

    • 3ollaseCung

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    #esiratory roblems ha!e le!els of se!erity

    #esiratory distress)

    #esiratory failure) and #esiratory arrest%

    4+

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    #esiratory /mergencies

    E #esiratory distress is a state $here achild is able to maintain ade*uateoxygenation of the blood) but only by

    increasing his or her $ork of breathing%

    E #esiratory failure occurs $hen a child

    cannot comensate for inade*uateoxygenation and the circulatory andresiratory systems begin to collase%

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    #esiratory /mergencies

    E #esiratory arrest

    are unresonsi!e and lim) $ith cyanosisaround the lis%

    #esiratory rate and $ork of breathingmay be !ery slo$ or absent) or you maynote agonal resiration

    Dinfre*uent) gasing breaths $ith nochest rise

    Da attern that is seen in dying

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    #esiratory arrest

    3hildren are unresonsi!e andlim) $ith cyanosis around the lis%

    #esiratory rate and $ork ofbreathing may be !ery slo$ orabsent) or you may note agonal

    resirationDinfre*uent) gasingbreaths $ith no chest rise

    4-

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    #esiratory arrest is the mostcommon cause of cardiac arrest inchildren and outcomes are oor for

    atients $ho de!elocardioulmonary arrest as the resultof resiratory deterioration

    49

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    3linical e!aluation of#esiratory /mergency

    .ow do yo# initially assess apatient in respiratory distress/

    +0

    should be rapid and 0#ickly deter$ineif atient needs emergent inter!entions

    and rule out life threatening conditions

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       P   E   N   A   M   P

       I   &   A   N

    )    P   A   

    Y    A    N    

    A   9    A   '   

    'IRK)&A'I K)&IT

    ;3

    T = Tonus

    I =Interactiveness C = Consolability  L = Look/Gaze S = Speech/Cry 

    Suara nafasabnormal

    Posisi abnormal Retraksi apas cupin!

    hi"un!

    #ottle" Pucat Sianosi

    s

    'EGITIGA PENI&AIAN PEDIATRIK  P$%I&TRIC &SS$SS#$T TRI&GL$ = P&T'

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    • A)ter *+m,leting the Triangle9begin a m+re *+m,lete

    •    pediatric primary sur!ey (

    AIRWAY

    BREATHING

    CIRCULATION

    DISABILITY

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    Tachynea: Eorld @ealthOrgani(ation

    +ge -reaths per $in#te

    Cess than ' months "60 breathsmin

    ' to 1' months "+0 breathsmin

    1 to + years "40 breathsmin

    ?ore than + years "'0 breathsmin

    #eroduced $ith ermission from: Eorld @ealth Organi(ation% The management of acute resiratory infections inchildren% 2n: 8ractical guidelines for outatient care% Eorld @ealth Organi(ation) >ene!a) 199+% 3oyright F199+ Eorld@ealth Organi(ation%

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    =iagnostic studies for e!aluationof acute resiratory distress

    -edside testing1 8ulse oximetry

    2N=235T2ON:

    5ll atients $ith resiratory distress

    +4

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    =iagnostic studies for e!aluationof acute resiratory distress

    -edside testing1 8ulse oximetry

    Normal !alues desite hyoxia seen in atients $ith se!ereanemia) carboxyhemoglobin) or sickle cell disease

    .alsely lo$ !alues obtained in atients $ith ulse oximeter

    not correlating $ith ulse) oor eriheral erfusion) !enouscongestion) methemoglobinemia) certain nail olish colors)and in atients recei!ing !ital dyes 7eg) methylene blueduring surgical rocedures

    ++

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    =iagnostic studies for e!aluationof acute resiratory distress

    Test Indications Co$$ents

    -edside testing

    /ndtidal

    3O'7/T3O'

    measurement

    3onfirmation of

    succesful endotracheal

    intubationNonin!asi!e monitoring

    of !entilation inintubated atients

    Nonin!asi!e monitoringfor sedation in children

    ?easurable in nonintubated and

    intubated) atients

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    -edside testing

    /lectrocar

    diogram

    3linical susicion of

    cardiac disease

    7eg) cardiacmurmur) gallo)

    differential ulsesor blood ressure

    bet$een uer andlo$er extremities

    Tyically combined $ith chestradiograh to assess heart si(e and

    ulmonary !asculature in order todetermine need for echocardiograhy

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    aboratory testing

    5rterial blood

    gas

    =etermine 8aO' for

    calculation of

    hysiologic measuresof oxygenation 7eg) 5

    a gradient) 8aO'.iO'ratio

    3orrelate 3O' $ithendtidal 3O'

    measurments?easure @ and

    correlate $ith !enous@

    /ndtidal 3O') ulse oximetry)and !enous blood gases may be

    used as less in!asi!e methodsfor ongoing monitoring of

    oxygenation) !entilation) andacidbase status if they

    correlate $ith arterial blood gasmeasurements

    d f l

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    aboratory testing/lectrolytes

    ) blood urea

    nitrogen)creatinine

    8atients $ith

    metabolic acidosis

    5ssesses for the resence of

    an anion ga and renaldysfunction

    >lucose5ltered mental

    status 

    5mmonia

    5ltered mentalstatus and other

    findings suggesti!e

    of urea cycle

    defects

     

    d f l

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    aboratory testing

    3arboxyhemoglobin

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    aboratory testing

    =dimer

    3linical findings

    suggesti!e of

    ulmonary embolus7eg) lo$ oxygenation)

    leuritic chest ain)$edgeshaed

    infiltrate on chestradiograh) and

    redisosing conditionGeg) sickle cell

    disease) thromboticconditionH

    8ulmonary embolus is a rare

    cause of resiratory distress in

    children2maging otions in atients $ith

    moderate to high clinicalrobability and ele!ated =

    dimer include!entilationerfusion scan)

    ultrasound of extremity !einsand dee !eins) 3T ulmonary

    angiograhy) and ulmonaryangiograhy

    =i ti t di f l ti

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    I$aging

    Cateral neckradiograh

    3linical findings

    suggesti!e ofeiglottitismretroharyngealabscess or ingested

    foreign body

    3rou can usually bediagnosed clinically

    $ithout a radiograh

    3hest

    radiograh

    5ll children $ith

    significantresiratory distress

    and those $ith focal

    lung findings

     

    =i ti t di f l ti

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    I$aging.orced

    exiratory or

    bilateraldecubitus

    chestradiograh

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    =iagnostic studies for e!aluation

    of acute resiratory distressTest Indications Co$$ents

    I$aging

    5bdominalradiograhs

    7suine and

    uright) orcrosstable

    lateral

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    3rou lateral neck radiograh

    66Cateral neck radiograh sho$ing subglottic narro$ing and

    distended hyoharynx consistent $ith acute laryngotracheitis%

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    Aacterial tracheitis

    6,

    Cateral neck radiograh sho$ing intraluminal membranes and tracheal $allirregularity consistent $ith bacterial tracheitis%3ourtesy of #% 8aul >uillerman) ?=) =eartment of #adiology) Aaylor 3ollege of?edicine%

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    #etroharyngealabscess

    6-

    Cateral neck radiograh demonstrating $idening of the retroharyngeal sace and re!ersal of thenormal cer!ical sine cur!ature% The retroharyngeal sace is considered $idened if it is greater than, mm at 3' or 14 mm at 36% The eiglottis and subglottic area in this radiograh are normal%

    3ourtesy of Koe Alack) =eartment of =iagnostic 2maging) Texas 3hildrenJs @osital%

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    >/N/#5C 5

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    ,0

    52#E5L 5

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    52#E5L 5

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    5ir$ay and Areathing?anagement

    8ositioning is the first ste in air$aymanagement%

    2nfants : should be laced in the

    Isniffing ositionI by a head tilt3hinlift or Ba$thrust maneu!er thatbrings the angle of the chin u 90

    degrees from the bed

    ,'

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    5ir$ay Obstruction

    3rou 5 !iral infection of the air$ay belo$

    the le!el of the !ocal cords

    /iglottitis 2nfection of the soft tissue in the

    area abo!e the !ocal cords

    .oreign body air$ay obstructions

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    3rou

    is a common !iral infection that usuallyaffects children ' to 4 years old%

    affects the larynx and trachea) although

    this illness may also extend to thebronchi%

    -+& of children to ha!e mild crou)

      less than 1& $ith se!ere crou%

    ,4

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    3rou

    Tyical signs include a lo$grade fe!erof -M3 to 9M3)

    a sealbark cough) and stridor)

    articularly if the child is agitated% onset is gradual%

    Areathing roblems $orsen at night) and

    may aear se!ere and extremelyusetting to caregi!ers%

    ,+

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    /iglottitis

    5 bacterial infection that usually affectschildren 4 to 6 years old

    usually resents $ith a higher fe!er rangingfrom 9M3 to 40M3%

    =ifficulty s$allo$ing may cause the child todrool%

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    Aacterial tracheitis

    This bacterial infection causes thetrachea to s$ell)

    resulting in artial air$ay obstruction%

    @igh fe!er)

    lo$itched stridor 7a snoring sound

    a roducti!e cough are usually

    resent

    -0

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    &'

    Questions ?

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    -

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    -4

    $+ngenital an+malies ass+*iated with strid+r

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    gMa"o#ation Caa2teisti2s

    N+se Nasal de)+rmities$h+anal atresia +r agenesis9 se,tum de)+rmities9 turbinateh-,ertr+,h-9 vestibular atresia +r sten+sis(

    Phar-n

    $rani+)a*ialan+malies

    An+malies *ausing )a*ial retrusi+n are ass+*iated with u,,erairwa- +bstru*ti+n9 in*luding $r+u7+nHs9 Pierre R+bin9 and A,ertHsS-ndr+me(

     T+ngue #a*r+gl+ssia and gl+ss+,t+sis

    %ar-n 

    %ar-ng+mala*ia#+st *+mm+n *ause +) *hr+ni* strid+r in in)ants( Alm+st all,atients ,resent b- J weeks +) age( S-m,t+ms are m+re,r+n+un*ed a)ter u,,er res,irat+r- in)e*ti+ns(

    %ar-ngeal webs; ,er*ent l+*ated in the gl+tti* area( $+m,lete webs *auseres,irat+r- distress at birth9 ,artial webs ,r+du*e strid+r9 weak*r- and di1erent degrees +) res,irat+r- distress(

    %ar-ngeal *-sts%+*ated in su,ragl+tti* area ma- *ause res,irat+r- distress andstrid+r(

    Subgl+tti*hemangi+ma

    Presents as ,r+gressive l+ud strid+r with in*reased res,irat+r-distress( Ass+*iated with hemangi+mas in +ther ,arts +) theb+d-(

    Subgl+tti* sten+sis#a- be *+ngenital but m+re +)ten a*@uired se*+ndar- t+intubati+n( Usuall- l+*ated 5. 8 mm bel+w the gl+ttis(

     Tra*he

    a

     Tra*heal sten+sisUsuall- ,resent with strid+r +r b+th strid+r and whee7ing( I)sten+sis is signi*ant9 res,irat+r- distress +**urs(

    Las*ular rings +rslings

    : ,er*ent +) vas*ular rings are s-m,t+mati*(

    Ass+*iated with +ther *+ngenital an+malies( #a- be se*+ndar-t+ a vas*ular rin +r * sts( 4+rsens with u er res irat+r

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    =efinitions

    -6

    +c#te respiratory fail#re

    •  inability of the lung to meet themetabolic demands of the body%

    • This can be from failure of tissue

    oxygenation andor failure of 3O'homeostasis

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    =efinitions

    hyoxaemic resiratory failure:

    8aO' ≤ +0 mm @g $hen

    breathing room air

    hyercanic resiratory failure:

    8a3O'≥ +0 mm @g%

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    Aasic resiratory hysiology

    --

    The maBor function of the lung is to get oxygen into thebody and carbon dioxide out

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    !5$!5

    body and carbon dioxide out

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    90

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    Oxygen in

    =eends on

    85O'

    =iffusing caacity

    8erfusion

    entilationerfusion matching

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    $arb+ndi+ide

    4aterva,+ur

    !-gen

    Nitr+gen 

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    Oxygen in =eends on

    85O

    '

    .2O' 853O' 5l!eolar ressure entilation

    =iffusing caacityOksigen terusmenerus berdifusi dari udara dalam al!eoli ke dalam aliran darahdan karbon dioksida 73O' terus berdifusi dari darah ke dalam al!eoli% Dif#si 

    adalah ergerakan molekul dari area dengan konsentrasi tinggi ke areakonsentrasi rendah% =ifusi udara resirasi terBadi antara al!eolus denganmembrane kailer% 8erfusion:

    8erfusi aru adalah gerakan darah mele$ati sirkulasi aru untuk dioksigenasi)dimana ada sirkulasi aru adalah darah deoksigenasi yang mengalir dalamarteri ulmonaris dari !entrikel kanan Bantung% entilationerfusion matching:

    entilasi adalah roses keluar masuknya udara dari dan aruaru) Bumlahnyasekitar +00 ml

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    3arbon dioxide out

    Cargely deendent on al!eolar!entilation

    5natomical deadsace constant buthysiological deadsace deends on!entilationerfusion matching

     

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    3arbon dioxide out

    #esiratory rate

    Tidal !olume

    entilationerfusion matching

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     8athohysiology

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    @yoxemia) defined as a decreasedle!el of oxygen in the blood

    hyoxia) defined as a decreased le!el

    of oxygen in the tissues%

    %

    9,

    These ' conditions may be

    closely related and may or maynot coexist) but they are notsynonymous

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    3auses of @yoxemia

    ?ismatch bet$een al!eolar !entilation 7 andulmonary erfusion 7P

    2ntraulmonary shunt

    @yo!entilation

    5bnormal diffusion of gases at the al!eolarcaillary interface

    #eduction in insired oxygen concentration

    2ncreased !enous desaturation $ith cardiacdysfunction lus one or more of the abo!e +factors

    9-

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    The most imortant abnormalities ingas exchange that lead to resiratoryfailure are

    P mismatch)intraulmonary shunt) and

    hyo!entilation

    99

    9 *:

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     9I*:

    ;enti"ation.itout

    peusion3!ea!spa2eenti"ationM

    Di

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    101

    8erfusi  Balan darah menuBu embuluh darah aru

    =ifusi  ergerakan oksigen dan karbon dioksida melintasi

    membran kailer al!eoli

    entilasi   ertukaran udara dari rongga al!eoli dan

    atmosfer

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    ;= ;=

    3

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    7

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    7shunting

    2ntraulmonary

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    P mismatch:

    Dead space entilation

      5l!eoli that are normally !entilated butoorly erfused

    +nato$ic dead space  >as in the large conducting air$ays that does

    not come in contact $ith the caillaries e%gharynx

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    P mismatch:

    Dead space entilation

    8hysiologic dead sace

      5l!eolar gas that does not e*uilibrate fully $ithcaillary blood

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    Diff#sion abnor$ality:

    Cess common

    5bnormality of the al!eolar membrane or a

    reduction in the number of caillariesresulting in a reduction in al!eolar surfacearea

    3auses include: 5cute #esiratory =istress

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    @yo!entilation

    can be caused by disease at any of the anatomical sites

    in!ol!ed in !entilation%

    Arainstem inBury or disease mayresult in imaired functioning of theresiratory centre)

    imaired functioning of theresiratory centre $hich suressedby deressant drugs

    109

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    Brainstem

    S,inal*+rdNerve r++tAirwa-

    Nerve

    Neur+mus*ular 0un*ti+n

    Res,irat+r-mus*le

    %ung

    Pleura

    $hest

    wall

    es at .i2 !isease #a, 2ause enti"ato, !istu-an

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    111

    • The ner!e roots may be damaged by trauma or tumour•  ner!e inBuries and neuroathies such as >uillain Aarre or

    critical illness neuroathy may affect motor neuronssulying resiratory muscles

    • Neuromuscular blockers or disease of the neuromuscular Bunction 7eg myasthenia gra!is may imair transmission of

    ner!e imulses to resiratory muscles• Or the roblem may be in the muscle itself% #esiratory

    muscle fatigue) disuse atrohy and malnutrition areimortant causes of resiratory muscle failure in the 23

    • 5lternati!ely the roblem may be a roblem of increasedresistance to airflo$% .or examle due to obstruction of the

    uer air$ay or bronchosasm• Or the roblem may be decreased comliance of the lung

    itself) the leura or the chest $all%

    #esiratory .ailure

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    #esiratory .ailure

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    #esiratory .ailure

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    3linical

    #esiratory comensation

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    3linical

    #esiratory comensation Tachynoea 5ccessory muscles

    #ecesssion Nasal flaring

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    3linical

    #esiratory comensation

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    3linical

    #esiratory comensation

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    3linical

    5ltered mental state

    =PaO2 3 PaCO2 acidosis> ? ?dilatation of cerebral resistance

    esseles ICP? >

    =isorientation @eadache

    coma asterixis

    ersonality changes

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    3linical

    #esiratorycomensation

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    Caboratory Testing

    5rterial blood gas8aO'

    8a3O'

    8@

    3hest imaging3hest xray

    3T sacn

    ltrasound

    #esiratory .ailure

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    Caboratory Testing

    Other tests@emoglobin

    /lectrolytes) blood urea nitrogen) creatinine

    3reatinine hoshokinase) aldolase/R>) echocardiogram

    /lectromyograhy 7/?>

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    8 l i t

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    Pa!5 kPaM

       A   b  s  a   t  u  r  a   t   i  +  n   F   =

       M

    O<

    8ulse oximetry

    < f

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    C *

    I" CRITIC+ TO+C.IE5IN'

    -OT. "*R5I5+ +ND+ F+5OR+-E

    NE*ROO'ICO*TCO(E 7