26
45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian, Epidemiologi, dan Kriteria Diagnosis. Informasi Laboratorium Prodia. 2006;4. 2. WHO. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complication. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva: 1999. 3. Hossain S, Fatema K, Ahmed KR. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Clin Res Rev. 2014;394:4. 4. Cameron A, Shaw J, Zimmet P. The metabolic syndrome: prevalence in worldwide populations. 2004;33:351-75. 5. Kamso S, Purwantyastuty, Lubis DU, Robbi YK, Besral. Prevalensi dan Determinan Sindrom Metrabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya. Jurnal Kesehatan Masyarakat Nasional. 2011;6:85-90. 6. Soewondo P, Purnamasari D, Oemardi M, Waspadji S, Soegondo S. Prevalence of Metabolic Syndrome Using NCEP/ATP III Criteria in Jakarta, Indonesia: The Jakarta Primary Non-communicable Disease Risk Factors Surveillance 2006. Department of Internal Medicine. Faculty of Medicine. University of Indonesia: 2010;42. 7. Kamso S. Metabolic syndrome in the Indonesian Elderly Medical Journal of Indonesia. 2007;16. 8. Yu D, Simmons D. Association between lung capacity measurements and abnormal glucose metabolism: findings from the Crossroads study. Diabetic medicine : a journal of the British Diabetic Association. 2014;31:595-9. 9. Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, et al. Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. Internal medicine. 2012;51:2291-7. 10. Zammit C, Liddicoat H, Moonsie I, Makker H. Obesity and respiratory diseases. International journal of general medicine. 2010;3:335-43.

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45

DAFTAR PUSTAKA

1. Adrianjah H, Adam J. Pengertian, Epidemiologi, dan Kriteria Diagnosis.

Informasi Laboratorium Prodia. 2006;4.

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5. Kamso S, Purwantyastuty, Lubis DU, Robbi YK, Besral. Prevalensi dan

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9. Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, et al.

Relationships of decreased lung function with metabolic syndrome and

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10. Zammit C, Liddicoat H, Moonsie I, Makker H. Obesity and respiratory

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42. Paek Y-J, Jung K-S, Hwang Y-I, Lee K-S, Lee DR, Lee J-U. Association

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44. Wright B. A miniature wright peak-flow meter. Br Med J. 1978;2:1627-8.

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56. Tammeling G, Berg W, Sluiter H. Estimation of the extrathoracic collapse

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of potentially modifiable risk factors associated with myocardial infarction

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65. Seo JA, Kim BG, Cho H, Kim HS, Park J, Baik SH, et al. The cutoff values

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and rate of lung function decline: a longitudinal analysis. Int J Tuberc Lung.

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70. Paek Y-J, Jung K-S, Hwang Y-I, Lee K-S, Lee DR, Lee J-U. Association

between low pulmonary function and metabolic risk factors in Korean

adults: the Korean National Health and Nutrition Survey. Metabolism

Clinical and Experimental. 2010;58:1300-6.

71. Yeh F, Dixon AE, Marion S, Schaefer C, Zhang Y, Best LG, et al. Obesity

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Syndrome and Diabetes. Diabetes Care. 2011;34:2306-13.

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LAMPIRAN

Lampiran 1. Ethical clearance

Page 9: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

53

Lampiran 2. Informed consent

PERSETUJUAN SETELAH PENJELASAN

(INFORMED CONSENT)

Selamat pagi/siang/sore, Ibu/Bapak. Kami adalah mahasiswa Fakultas

Kedokteran Universitas Diponegoro yang sedang mengadakan penelitian tentang

gangguan metabolik. Penelitian ini bertujuan untuk mengetahui hubungan lingkar

pinggang dengan arus puncak pengeluaran napas pada masyarakat dengan

gangguan metabolik. Kami membutuhkan ketersediaan Ibu/Bapak untuk

melakukan beberapa tes: Harvard step test (tes naik turun bangku), tes kekuatan

genggaman tangan, arus puncak pengeluaran napas, dan laboratorium darah sebagai

sampel penelitian yang akan kami periksa serta menjawab beberapa pertanyaan

yang berhubungan dengan penelitian kami. Manfaat dari penelitian ini adalah

Ibu/Bapak akan mendapatkan pemeriksaan laboratorium darah yang meliputi asam

urat, gula darah puasa dan kolesterol tanpa dipungut biaya apapun. Selain itu,

Bapak/Ibu juga akan mendapatkan penyuluhan tentang pencegahan faktor-faktor

yang dapat menyebabkan gangguan metabolik.

Kami menjamin bahwa penelitian ini tidak akan menimbulkan efek yang

merugikan pada Bapak/Ibu. Penelitian yang kami lakukan ini bersifat sukarela dan

tidak ada unsur paksaan. Dalam penelitian ini, kami menjamin kerahasiaan segala

data yang kami peroleh, data hanya akan kami gunakan untuk kepentingan

penelitian. Penanggung jawab penelitian ini adalah dr. Bahrudin, M.Si.Med, Ph.D,

dosen Bagian Anatomi FK Undip. Alamat kantor: Jl. Prof. Dr. Soedarto,

Tembalang, Semarang, nomor HP 081228000876.

Demikian penjelasan dari kami. Terima kasih atas kerja sama Bapak/Ibu

dalam penelitian ini.

Setelah mendengar dan memahami penjelasan penelitian, dengan ini saya

menyatakan

SETUJU / TIDAK SETUJU

untuk menjadi subjek penelitian.

Semarang, ……………………. 2015

Saksi

Nama Terang Nama Terang

Alamat: Alamat:

Page 10: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

54

Lampiran 3. Identitas Subjek Penelitian

IDENTITAS SUBJEK PENELITIAN

“FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP SINDROM

METABOLIK”

I. IDENTITAS

1. Nama :

2. Tempat, tanggal lahir : Usia: tahun.

3. Jenis kelamin :

4. Alamat :

RT/RW :

Kelurahan :

Kecamatan :

5. No. telepon/HP :

6. Pendidikan :

( ) Tidak sekolah

( ) Tidak tamat

SD/sederajat

( ) Tamat SD/sederajat

( ) Tamat SMP/sederajat

( ) Tamat SMA/sederajat

( ) Tamat perguruan tinggi/sederajat

7. Pekerjaan :

( ) Tidak bekerja

( ) Petani

( ) Wiraswasta

( ) PNS

( ) Lain-lain, sebutkan ...........

II. Riwayat Penyakit

1. Riwayat DM : Ya Tidak

Tidak tahu

Jika Ya: . . . . tahun, terkontrol/tidak

terkontrol

Page 11: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

55

2. Riwayat Hipertensi : Ya Tidak

Tidak tahu

Jika Ya: . . . . tahun, terkontrol/tidak

terkontrol

3. Riwayat Kolestrol tinggi

(Dislipidemia)

: Ya Tidak

Tidak tahu

Jika Ya: . . . . tahun, terkontrol/tidak

terkontrol

4. Riwayat Stroke : Ya Tidak

Tidak tahu

Jika Ya: . . . . tahun, terkontrol/tidak

terkontrol

5. Riwayat Merokok : ( ) Tidak pernah

( ) Pernah, sudah berhenti sejak …..

bulan yang lalu

( ) Merokok aktif ……… batang/hari

6. Riwayat Keluarga : - Siapa dari keluarga Bapak/Ibu yang

menurunkan penyakit tersebut?

- Sejak umur berapa Bapak/Ibu

mengidap penyakit tersebut?

7. Riwayat Obat-obatan :

II. PEMERIKSAAN

1. Tekanan Darah (mmHg) : S: D: mmHg. HR:

x/menit

2. Tinggi Badan (cm) :

3. Berat Badan (kg) :

4. Lingkar Pinggang (cm) :

Page 12: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

56

Lampiran 4. Pemeriksaan fisik subjek penelitian

PEMERIKSAAN FISIK SUBJEK PENELITIAN

“FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP SINDROM

METABOLIK”

Kepala : Konjungtiva anemis ( )

Sklera ikterik ( )

Lain-lain......................................................................

Leher : JVP.......................................................................................

Dada : Jantung (Bunyi jantung): ....................................................

................................................................................................

Paru: ...................................................................................

Abdomen : ..............................................................................................

Ekstremitas : ..............................................................................................

Rekomendasi : Ya Tidak

1. Peak flow meter ( ) ( )

2. Hand Grip Dynamometer ( ) ( )

3. Harvard Step Test ( ) ( )

Semarang, 18 Januari 2015

(………………………………………)

Dokter

Page 13: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

57

Lampiran 5. Hasil analisis statistik

Descriptive Statistics

N Minimum Maximum Mean Std.

Deviation

Umur (tahun) 30 41 76 56.93 8.233

Valid N (listwise) 30

Descriptive Statistics

N Minimum Maximum Mean Std.

Deviation

Tinggi Badan (cm) 30 137.0 173.0 154.323 8.4734

Berat Badan (kg) 30 41.0 80.0 65.183 9.2861

IMT (kg/m2) 30 18.7 34.6 27.365 3.3284

Valid N (Listwise) 30

Tests Of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statisti

c

df Sig. Statistic df Sig.

Umur (tahun) .107 30 .200* .974 30 .657

Tinggi Badan (cm) .072 30 .200* .987 30 .964

Berat Badan (kg) .119 30 .200* .955 30 .236

GDP (mg/dL) .258 30 .000 .718 30 .000

HDL (mg/dL) .125 30 .200* .956 30 .250

TG (mg/dL) .143 30 .121 .939 30 .087

IMT (kg/m2) .097 30 .200* .984 30 .926

Tekanan Sistolik (mmHg) .129 30 .200* .961 30 .328

Tekanan Diastolik

(mmHg)

.144 30 .115 .962 30 .346

*. This Is A Lower Bound Of The True Significance.

A. Lilliefors Significance Correction

Page 14: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

58

Descriptive Statistics

N Minimum Maximum Mean Std.

Deviation

Tekanan Sistolik (mmHg) 30 124 218 161.43 22.538

Tekanan Diastolik (mmHg) 30 60 125 88.17 13.249

HDL (mg/dL) 30 29 61 41.70 7.340

TG (mg/dL) 30 62 350 161.23 67.108

Valid N (Listwise) 30

Statistics

GDP (mg/dL)

N Valid 30

Missing 0

Median 102.50

Jenis Kelamin

Frequency Percent Valid Percent Cumulative Percent

Valid

Perempuan 22 73.3 73.3 73.3

Laki-Laki 8 26.7 26.7 100.0

Total 30 100.0 100.0

Status Gizi

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 2 6.7 6.7 6.7

Berat Badan Lebih 5 16.7 16.7 23.3

Obestas 1 17 56.7 56.7 80.0

Obesitas Ii 6 20.0 20.0 100.0

Total 30 100.0 100.0

Riwayat Merokok

Frequency Percent Valid Percent Cumulative

Percent

Valid

Tidak 28 93,3 93,3 93,3

Ya 2 6,7 6,7 100,0

Total 30 100,0 100,0

Page 15: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

59

Kategori Tekanan Darah Sistolik

Frequency Percent Valid Percent Cumulative

Percent

Valid

Prehipertensi 5 16,7 16,7 16,7

Hipertensi derajat 1 12 40,0 40,0 56,7

Hipertensi Derajat 2 13 43,3 43,3 100,0

Total 30 100,0 100,0

Kategori Tekanan Darah Diastolik

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 7 23,3 23,3 23,3

Prehipertensi 9 30,0 30,0 53,3

Hipertensi derajat 1 10 33,3 33,3 86,7

Hipertensi derajat 2 4 13,3 13,3 100,0

Total 30 100,0 100,0

Kategori Lingkar Pinggang

Frequency Percent Valid Percent Cumulative

Percent

Valid

NORMAL 2 6,7 6,7 6,7

MENINGKAT 14 46,7 46,7 53,3

MENINGKAT

TAJAM

14 46,7 46,7 100,0

Total 30 100,0 100,0

Kategori Gula Darah Puasa

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 19 63,3 63,3 63,3

Meningkat 11 36,7 36,7 100,0

Total 30 100,0 100,0

Page 16: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

60

Kategori HDL

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 6 20,0 20,0 20,0

Rendah 24 80,0 80,0 100,0

Total 30 100,0 100,0

Kategori Trigliserida

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 15 50,0 50,0 50,0

Meningkat 15 50,0 50,0 100,0

Total 30 100,0 100,0

Tests Of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Arus Puncak Ekspirasi

(L/menit)

,080 30 ,200* ,974 30 ,643

Lingkar Pinggang (cm) ,130 30 ,200* ,962 30 ,349

*. This is a lower bound of the true significance.

A. Lilliefors significance correction

Descriptive Statistics

N Minimum Maximum Mean Std.

Deviation

Arus Puncak Ekspirasi (L/Menit) 30 180 570 352.67 101.572

Valid N (Listwise) 30

Descriptive Statistics

N Minimum Maximum Mean Std.

Deviation

Lingkar Pinggang (cm) 30 74 112 91.33 7.617

Valid N (Listwise) 30

Page 17: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

61

Kategori APE

Frequency Percent Valid Percent Cumulative

Percent

Valid

Normal 13 43.3 43.3 43.3

Tidak Normal 17 56.7 56.7 100.0

Total 30 100.0 100.0

6,66%

2

46,67%

14

46,67%

14

Normal

Meningkat

Meningkat tajam

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43,3%

1356,7%

17 Normal

Tidak Normal

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63

Correlations

Arus Puncak

Ekspirasi

(L/menit)

Lingkar

Pinggang (cm)

Arus Puncak Ekspirasi

(L/menit)

Pearson Correlation 1 -.420*

Sig. (2-tailed) .021

N 30 30

Lingkar Pinggang (cm)

Pearson Correlation -.420* 1

Sig. (2-tailed) .021

N 30 30

*. Correlation is significant at the 0.05 level (2-tailed).

Kategori Lingkar Pinggang * KAT_APE Crosstabulation

Kategori APE Total

Normal Tidak Normal

Kategori Lingkar

Pinggang

Normal

Count 2 0 2

Expected Count ,9 1,1 2,0

% within

Kategori LP

100,0% 0,0% 100,0%

Meningkat

Count 8 6 14

Expected Count 6,1 7,9 14,0

% within

Kategori LP

57,1% 42,9% 100,0%

Meningkat Tajam

Count 3 11 14

Expected Count 6,1 7,9 14,0

% within

Kategori LP

21,4% 78,6% 100,0%

Total

Count 13 17 30

Expected Count 13,0 17,0 30,0

% within

Kategori LP

43,3% 56,7% 100,0%

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64

Chi-Square Tests

Value df Asymp.

Sig. (2-

sided)

Monte Carlo Sig. (2-sided)

Sig. 95% Confidence Interval

Lower Bound Upper Bound

Pearson Chi-Square 6,438a 2 ,040 ,027b ,024 ,030

Likelihood Ratio 7,384 2 ,025 ,027b ,024 ,030

Fisher's Exact Test 5,956 ,027b ,024 ,030

Linear-by-Linear

Association

6,200c 1 ,013 ,014b ,011 ,016

N of Valid Cases 30

a. 2 cells (33,3%) have expected count less than 5. The minimum expected count is ,87.

b. Based on 10000 sampled tables with starting seed 2000000.

c. The standardized statistic is 2,490.

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65

Correlations

Kat APE Umur (tahun)

Spearman's rho

Kat APE

Correlation

Coefficient

1.000 .436*

Sig. (2-tailed) . .016

N 30 30

Umur (tahun)

Correlation

Coefficient

.436* 1.000

Sig. (2-tailed) .016 .

N 30 30

*. Correlation is significant at the 0.05 level (2-tailed).

Correlations

Kat APE Tinggi Badan

(cm)

Spearman's rho

Kat APE

Correlation

Coefficient

1.000 .101

Sig. (2-tailed) . .595

N 30 30

Tinggi Badan (cm)

Correlation

Coefficient

.101 1.000

Sig. (2-tailed) .595 .

N 30 30

Chi-Square Tests Kat APE dengan Status Gizi

Value df Asymp. Sig.

(2-sided)

Pearson Chi-Square 7.538a 3 .057

Likelihood Ratio 8.569 3 .036

Linear-by-Linear

Association

6.840 1 .009

N of Valid Cases 30

a. 6 cells (75,0%) have expected count less than 5. The minimum

expected count is ,87.

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66

Chi-Square Tests Kat APE dengan JK

Value df Asymp. Sig.

(2-sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)

Pearson Chi-Square 1.493a 1 .222

Continuity Correctionb .649 1 .421

Likelihood Ratio 1.558 1 .212

Fisher's Exact Test .407 .212

Linear-by-Linear

Association

1.443 1 .230

N of Valid Cases 30

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 3,47.

b. Computed only for a 2x2 table

Correlations

Arus Puncak

Ekspirasi

(L/menit)

Berat Badan

(kg)

Arus Puncak Ekspirasi

(L/menit)

Pearson Correlation 1 .052

Sig. (2-tailed) .783

N 30 30

Berat Badan (kg)

Pearson Correlation .052 1

Sig. (2-tailed) .783

N 30 30

Chi-Square Tests Kat APE dengan Riwayat Merokok

Value df Asymp. Sig.

(2-sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)

Pearson Chi-Square 2.802a 1 .094

Continuity Correctionb .875 1 .350

Likelihood Ratio 3.533 1 .060

Fisher's Exact Test .179 .179

Linear-by-Linear

Association

2.709 1 .100

N of Valid Cases 30

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is ,87.

b. Computed only for a 2x2 table

Page 23: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

67

Correlations

Arus Puncak

Ekspirasi

(L/menit)

Berat Badan

(kg)

Arus Puncak Ekspirasi

(L/menit)

Pearson Correlation 1 .052

Sig. (2-tailed) .783

N 30 30

Berat Badan (kg)

Pearson Correlation .052 1

Sig. (2-tailed) .783

N 30 30

Variables in the Equation

B S.E. Wald df Sig. Exp(

B)

95% C.I.for EXP(B)

Lower Upper

Step 1a

Umur .118 .083 2.018 1 .155 1.126 .956 1.325

Kat LP .419 .179 5.474 1 .019 1.521 1.070 2.160

Constant -44.164 17.192 6.599 1 .010 .000

a. Variable(s) entered on step 1: Umur, Kat LP.

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68

Lampiran 6. Dokumentasi penelitian

Gambar 11. Pendataan sampel penelitian

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69

Gambar 12. Pengambilan data berat badan, tinggi badan dan lingkar pinggang

Gambar 13. Pengambilan data APE

Page 26: 45 DAFTAR PUSTAKA 1. Adrianjah H, Adam J. Pengertian

70

Lampiran 7. Biodata mahasiswa

Identitas

Nama : Ihwanu Sholeh

NIM : 22010111130087

Tempat Lahir : Cirebon

Tanggal Lahir : 2 Juli 1991

Jenis Kelamin : Laki-laki

Alamat : Jl. Yudhistira No. 43 Desa Karangasem, Plumbon, Cirebon

Nomor HP : 08977261640

Email : [email protected]

Riwayat Pendidikan Formal

1. SD : SD Negeri 1 Karangasem Lulus tahun : 2003

2. SMP : SMP Negeri 1 Plumbon Lulus tahun : 2006

3. SMA : SMA Negeri 1 Cirebon Lulus tahun : 2009

4. S1 : Pendidikan Dokter Fakultas Kedokteran

Universitas Diponegoro Masuk tahun : 2011

Keanggotaan Organisasi

1. HIMA KU Universitas Diponegoro Tahun 2011-2013

2. ROHIS Fakultas Kedokteran Universitas Diponegoro Tahun 2011-2013