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Microsystems for biomedical and environmental applications
MicrofluidicsPart III: Commercial examples
Prof. Dr.-Ing. S. GaßmannSevilla 2018
Commercial microfluidic examples
- Abott I-stat - first blood gas analyzer- Edan 15 – yet another blood gas analyzer (nice video:
https://www.youtube.com/watch?v=o8W331MmMw0)
- Picollo Xpress – blood tests on a disk(https://www.abaxis.com/medical/piccolo-xpress)
- Roche Cobas Liat – DNA Analysis in a tube(https://diagnostics.roche.com/global/en/products/systems/cobas-liat-system.html)
- Bosch Vivalytics – platform for molecular diagnastics(https://www.bosch-vivalytic.com/en.html)
- Medimate Minilab – electrophoresis used for Lithium detection (www.medimate.com)
- Nutrient analyzer for oceanography (6 monthautonomy, 6000m depth)
2 von <8> Prof. Dr. Ing. Gaßmann FMEMS Summer School 2018
Point-Of-Care Analyzer (Bsp: I-Stat Abbott)
System for blood gases and electrolytes
Modular system– Handheld device– Data evaluation (download calibration data)– Microfluidic cartridge
detector: MEMS Biosensors– Amperometric, Potentiometric, Konduktometric
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 3 von <8> Mikrofluidische Anwendungen
Point-Of-Care Analyzer (I-Stat Abbott)
usage:fill the sample close insert and wait
External calibration (once a day)!Electric stimulator
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 4 von <8> Mikrofluidische Anwendungen
Centrifugal platforms
Forces:• Centrifugal force:
Fc = −mω × (ω × r)• Coriolis force
Euler Force
Pressure over a liquid column
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 15 von <8> Mikrofluidische Anwendungen
Fc = −mω × (ω × r)
Piccolo Xpressblood chemistry and electrolyte analyzer
• Principle: centrifugal forces• All tasks are performed on the
disc• Detection by absorption
measurement• Many discs with different tests
and combinations available(even veterinarianapplication!)
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 16 von <8> Mikrofluidische Anwendungen
Lithiumtest by electrophoresis
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 19 von <8> Mikrofluidische Anwendungen
• Detecting Lithium by electrophoresis• Disposable Chip with all integrated reagents• Reader for measurement
• Spinoff made by students of U Twente
teststrip reader
Medimate Minilab principle
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 20 von <8> Mikrofluidische Anwendungen
Source: www.medimate.com
Nutrient Analyzer for Oceanography
National Oceanography Centre SouthamptonOCEAN TECHNOLOGY AND ENGINEERING GROUPHead: Matt Mowlem
- development of lab-on-chip systems for oceanography- several analytes- long term deployment test- commercialization by technology transfer
Med. Mikrotechnik Prof. Dr. Ing. Gaßmann 21 von <8> Mikrofluidische Anwendungen
Phosphate Analyzer
• Grand Maxime et.al “A Lab-On-Chip Phosphate Analyzer for Long-term In Situ Monitoring at Fixed Observatories: Optimization and Performance Evaluation in Estuarine and Oligotrophic Coastal Waters”,Frontiers in Marine Science, Vol. 4, 2017 URL=https://www.frontiersin.org/article/10.3389/fmars.2017.00255
Microfluidics - Prof. Dr. Ing. Gassmann 22 von <8>
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