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CELL MEDIATED
HYPERSENSITIVITYMODERATOR------DR .VARSHA.A.SINGH
cell mediated hypersensitivity
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cell mediated hypersensitivity !
Hypersensitivity
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Human bodys way of keepn! "s #os" safe f$om
dsease and fo$e!n n%ade$s
cell mediated hypersensitivity "
Immune sys"em
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cell mediated hypersensitivity #
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Immune $esponse
I& An"body meda"ed ' #umo$a( Immune $esponse
II& Ce(( meda"ed Immune $esponse
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Hype$sens"%e $ea)"ons* E+a!!e$a"ed
mmune $esponse
cell mediated hypersensitivity $
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C(ass,)a"on
I& T$ad"ona( )(ass,)a"on
II& Coombs and -e(( )(ass,)a"on
III& C(n)a( )(ass,)a"on
cell mediated hypersensitivity %
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I& T$ad"ona( )(ass,)a"on
Immeda"e De(ayedRapid
Antibody
Circulating Abs present
Transferred by serum
Desensitization
Slow
cell mediated
Absent
Not transferred
difficult
cell mediated hypersensitivity &
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III& C(ass,)a"on based on C(n)a(manfes"aons
Immeda"e*anap#y(a+s
A"opy
An"body meda"ed )e(( dama!e
A$"#us p#enomenon
Se$um s)kness
De(ayed*nfe)"on."ube$)u(n/
Con"a)" de$ma""s "ype
cell mediated hypersensitivity (
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Type v hypersensitivityType V hypersensitivity is the )nal type *+
hypersensitivity in ,hich anti*dies are
pr*dced ,ith the pr*perty *+ stimlatin/
speci)c cell tar/ets.
Graves disease cased y anti*dies that
stimlate the thyr*id-stimlatin/ h*rm*ne
recept*r0 leadin/ t* *veractivity *+ the thyr*id
/land.
Type II hypersensitivitycell mediated hypersensitivity
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cell mediated hypersensitivity !
Type IV #ype$sens"%"y
0$ Ce(( meda"ed #ype$sens"%"y$ea)"ons
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Ce(( meda"ed #ype$sens"%"y $ea)"ons ' "ype IV#ype$sens"%"y
Gests ,h* c*me0 stay eat and react
cell mediated hypersensitivity "
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Immuno(o!)a( Me)#ansm of Type IV#ype$sens"%"y
1& Sens"2a"on p#ase
3& E4e)"o$ p#ase
cell mediated hypersensitivity #
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cell mediated hypersensitivity 1
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Cy"oknes n sens"2a"on p#ase
ma)$op#a!e en!u(fs A((e$!en
IL3
Pep"de ep"opes w"# MHC II
IL13
A)"%a"e TH CELLS
I5N !amma 6 TN5b
TH
T#1.CD7 )e((s/ 6 T#3.CD8)e((s/ 6 a)"%a"edma)$op#a!es
cell mediated hypersensitivity $
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cell mediated hypersensitivity %
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I& Con"a)" de$ma""s 78*93#$s
II& Infe)"on "ype 78*93#$s
III& -$anu(oma"ous 31*38days
cell mediated hypersensitivity &
an"s of de(ayed #ype$sens"%"y
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Con"a)" de$ma""s
An"!ens
Metals-2e,elry 3*is*ns
Ivy
4rshi*l
Nic5el
6hr*mim
cell mediated hypersensitivity '
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!(
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cell mediated hypersensitivity !
1& Sens"2a"on p#ase
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cell mediated hypersensitivity !!
E4e)"o$ p#ase
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6*ntact dermatitis
cell mediated hypersensitivity !"
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In+ecti*nOr/anisms-Myc*acterim tercl*sis
myc*. 7eprae
listeria m*n*cyt*/enes84NGI-candida alicans
hist*plasma capslatm
VIR4S-Herpes simple9
measles3ARASITE-7eishmania spp.
cell mediated hypersensitivity !#
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Tube$)u(n "es" 33D
macr*pha/es
indrati*n and erythmacell mediated hypersensitivity !1
Intradermally
A36s en/l+
mem*ry T cells
7ymph*5ines
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Tube$)u(n "es"
cell mediated hypersensitivity !$
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Granl*manon*spe),) "ype of n:amma"o$y $esponse
an"!en) a!en"s o$ by ne$" fo$e!n ma"e$a(s&
T (ymp#o)y"es and ma)$op#a!e!$anu(omas a$e fo$med as "#e $esu(" of "#e
)omp(e+ n"e$a)"on of )y"oknes p$odu)ed by"#ese )e((s&
.my)oba)"e$a< fun!< e")&/
be$y((um< "#e unknown an"!en $esponsb(e fo$sa$)odoss
cell mediated hypersensitivity !%
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Disease mani+estin/ type iv
/ranl*mat*s hypersensitivityT4:ER647OSIS
7E3ROS;
S6HISOTOSOMIASISSAR6OIDOSIS
6ROHN
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A36
T 6E77S
THIMMAT4RE MA6R3O3HAGE
E3ITHE7IOID 6E77
M47TIN467EATE GIANT 6E77
cell mediated hypersensitivity !'
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:*rderline lepr*sy reacti*n
hyp*pi/mented s5in lesi*ns
S,*llen and in=amed I8N y secretin/ lymph*cyets
MITS4DA REA6TION >M.7E3RAE ANTIGENS
?VEIM TEST-SAR6OIDOSIS
cell mediated hypersensitivity "(
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Au"ommune dseases asso)a"ed w"# TYPE IV#ype$sens"%"y
Dabe"es me(("us "ype 1
Mu("p(e s)(e$oss
R#euma"od a$"#$"s
pe$p#e$a( neu$opa"#es
Has#mo"o=s T#y$od"s
C$o#n=s dsease
cell mediated hypersensitivity "
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Type diaetesIS7ETS O8 7ANGERHANS
TRAGET ANTIGENS ARE-GAD0I6A-1!@IA-!03HOGRIN
AMINOA6ID SE4EN6E
6OBSA6?IE VIR4S 3ROTIEN AND IS7ET 6E77
A4TOANTIGENS
cell mediated hypersensitivity "!
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Mltiple scler*sis
cell mediated hypersensitivity ""
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M47TI37E S67EROSISAt*reactive T cells in2re rain tisse
Destrcti*n *+ myelin sheath
At* anti/ens are +*rmed a/ainst myelin asic pr*tien
pr*tei*lip*pr*tein
*li/*dendr*cyte
cell mediated hypersensitivity "#
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cell mediated hypersensitivity "1
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Rhemat*id arthritis6hr*nic in=ammat*ry disease
Virses
Mechanism- at*anti*dies are directed end*thelial cells
levels *+ adhesi*n m*lecles
e9travasati*n *+ lec*cytes
6D# T cells are pred*minant 6D& cells scattered in syn*vial
tisse
cell mediated hypersensitivity "$
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6D# T cells >I7!0TN8a0I7$0I7(0I7"0GM-6S8
tisse in=ammati*n 0 pr*li+erati*n 0
6artila/e dama/e
cell mediated hypersensitivity "%
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Hashim*t*mediated cell death
Recritment *+ macr*pha/e and dama/e t*+*llicles.
G*iter-an in=ammat*y resp*nse
cell mediated hypersensitivity "&
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All*/ra+t re2ecti*nAll*/ra+t as anti/en
T cells are activated
MH6II >6D#T 6ellsI7! release
Rec*/niti*n *+ speci)c anti/en
3er+*rins and /ranyymes
Ap*pt*sis
M*n*cytes y DTH
cell mediated hypersensitivity "'
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Recipient anti/en presentin/ cell /ra+t cells
6D#CHE73ER T 6E77S : 7;M3HO6;TE
I8Ny 37ASMA 6E77
ANTI:ODIES
A6TIVATED MA6RO3HAGES
RENA7 :7OOD VESSE7S
cell mediated hypersensitivity #(
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