Ekta Dr Hypersensitivity

7/24/2019 Ekta Dr Hypersensitivity

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CELL MEDIATED

HYPERSENSITIVITYMODERATOR------DR .VARSHA.A.SINGH

cell mediated hypersensitivity


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cell mediated hypersensitivity !

Hypersensitivity


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Human bodys way of keepn! "s #os" safe f$om

dsease and fo$e!n n%ade$s

cell mediated hypersensitivity "

Immune sys"em


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cell mediated hypersensitivity #


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Immune $esponse

I& An"body meda"ed ' #umo$a( Immune $esponse

II& Ce(( meda"ed Immune $esponse


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Hype$sens"%e $ea)"ons* E+a!!e$a"ed

mmune $esponse

cell mediated hypersensitivity $


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C(ass,)a"on

I& T$ad"ona( )(ass,)a"on

II& Coombs and -e(( )(ass,)a"on

III& C(n)a( )(ass,)a"on

cell mediated hypersensitivity %


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I& T$ad"ona( )(ass,)a"on

Immeda"e De(ayedRapid

Antibody

Circulating Abs present

Transferred by serum

Desensitization

Slow

cell mediated

Absent

Not transferred

difficult

cell mediated hypersensitivity &


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III& C(ass,)a"on based on C(n)a(manfes"aons

Immeda"e*anap#y(a+s

A"opy

An"body meda"ed )e(( dama!e

A$"#us p#enomenon

Se$um s)kness

De(ayed*nfe)"on."ube$)u(n/

Con"a)" de$ma""s "ype

cell mediated hypersensitivity (


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Type v hypersensitivityType V hypersensitivity is the )nal type *+

hypersensitivity in ,hich anti*dies are

pr*dced ,ith the pr*perty *+ stimlatin/

speci)c cell tar/ets.

Graves disease cased y anti*dies that

stimlate the thyr*id-stimlatin/ h*rm*ne

recept*r0 leadin/ t* *veractivity *+ the thyr*id

/land.

Type II hypersensitivitycell mediated hypersensitivity


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Type IV #ype$sens"%"y

0$ Ce(( meda"ed #ype$sens"%"y$ea)"ons


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Ce(( meda"ed #ype$sens"%"y $ea)"ons ' "ype IV#ype$sens"%"y

Gests ,h* c*me0 stay eat and react



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Immuno(o!)a( Me)#ansm of Type IV#ype$sens"%"y

1& Sens"2a"on p#ase

3& E4e)"o$ p#ase

cell mediated hypersensitivity #


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cell mediated hypersensitivity 1


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Cy"oknes n sens"2a"on p#ase

ma)$op#a!e en!u(fs A((e$!en

IL3

Pep"de ep"opes w"# MHC II

IL13

A)"%a"e TH CELLS

I5N !amma 6 TN5b

TH

T#1.CD7 )e((s/ 6 T#3.CD8)e((s/ 6 a)"%a"edma)$op#a!es

cell mediated hypersensitivity $


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cell mediated hypersensitivity %


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I& Con"a)" de$ma""s 78*93#$s

II& Infe)"on "ype 78*93#$s

III& -$anu(oma"ous 31*38days

cell mediated hypersensitivity &

an"s of de(ayed #ype$sens"%"y


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Con"a)" de$ma""s

An"!ens

Metals-2e,elry 3*is*ns

Ivy

4rshi*l

Nic5el

6hr*mim

cell mediated hypersensitivity '


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!(


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1& Sens"2a"on p#ase


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cell mediated hypersensitivity !!

E4e)"o$ p#ase


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6*ntact dermatitis

cell mediated hypersensitivity !"


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In+ecti*nOr/anisms-Myc*acterim tercl*sis

myc*. 7eprae

listeria m*n*cyt*/enes84NGI-candida alicans

hist*plasma capslatm

VIR4S-Herpes simple9

measles3ARASITE-7eishmania spp.

cell mediated hypersensitivity !#


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Tube$)u(n "es" 33D

macr*pha/es

indrati*n and erythmacell mediated hypersensitivity !1

Intradermally

A36s en/l+

mem*ry T cells

7ymph*5ines


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Tube$)u(n "es"

cell mediated hypersensitivity !$


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Granl*manon*spe),) "ype of n:amma"o$y $esponse

an"!en) a!en"s o$ by ne$" fo$e!n ma"e$a(s&

T (ymp#o)y"es and ma)$op#a!e!$anu(omas a$e fo$med as "#e $esu(" of "#e

)omp(e+ n"e$a)"on of )y"oknes p$odu)ed by"#ese )e((s&

.my)oba)"e$a< fun!< e")&/

be$y((um< "#e unknown an"!en $esponsb(e fo$sa$)odoss

cell mediated hypersensitivity !%


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Disease mani+estin/ type iv

/ranl*mat*s hypersensitivityT4:ER647OSIS

7E3ROS;

S6HISOTOSOMIASISSAR6OIDOSIS

6ROHN


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A36

T 6E77S

THIMMAT4RE MA6R3O3HAGE

E3ITHE7IOID 6E77

M47TIN467EATE GIANT 6E77

cell mediated hypersensitivity !'


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:*rderline lepr*sy reacti*n

hyp*pi/mented s5in lesi*ns

S,*llen and in=amed I8N y secretin/ lymph*cyets

MITS4DA REA6TION >M.7E3RAE ANTIGENS

?VEIM TEST-SAR6OIDOSIS

cell mediated hypersensitivity "(


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Au"ommune dseases asso)a"ed w"# TYPE IV#ype$sens"%"y

Dabe"es me(("us "ype 1

Mu("p(e s)(e$oss

R#euma"od a$"#$"s

pe$p#e$a( neu$opa"#es

Has#mo"o=s T#y$od"s

C$o#n=s dsease



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Type diaetesIS7ETS O8 7ANGERHANS

TRAGET ANTIGENS ARE-GAD0I6A-1!@IA-!03HOGRIN

AMINOA6ID SE4EN6E

6OBSA6?IE VIR4S 3ROTIEN AND IS7ET 6E77

A4TOANTIGENS

cell mediated hypersensitivity "!


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Mltiple scler*sis

cell mediated hypersensitivity ""


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M47TI37E S67EROSISAt*reactive T cells in2re rain tisse

Destrcti*n *+ myelin sheath

At* anti/ens are +*rmed a/ainst myelin asic pr*tien

pr*tei*lip*pr*tein

*li/*dendr*cyte

cell mediated hypersensitivity "#


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cell mediated hypersensitivity "1


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Rhemat*id arthritis6hr*nic in=ammat*ry disease

Virses

Mechanism- at*anti*dies are directed end*thelial cells

levels *+ adhesi*n m*lecles

e9travasati*n *+ lec*cytes

6D# T cells are pred*minant 6D& cells scattered in syn*vial

tisse

cell mediated hypersensitivity "$


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6D# T cells >I7!0TN8a0I7$0I7(0I7"0GM-6S8

tisse in=ammati*n 0 pr*li+erati*n 0

6artila/e dama/e

cell mediated hypersensitivity "%


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Hashim*t*mediated cell death

Recritment *+ macr*pha/e and dama/e t*+*llicles.

G*iter-an in=ammat*y resp*nse

cell mediated hypersensitivity "&


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All*/ra+t re2ecti*nAll*/ra+t as anti/en

T cells are activated

MH6II >6D#T 6ellsI7! release

Rec*/niti*n *+ speci)c anti/en

3er+*rins and /ranyymes

Ap*pt*sis

M*n*cytes y DTH

cell mediated hypersensitivity "'


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Recipient anti/en presentin/ cell /ra+t cells

6D#CHE73ER T 6E77S : 7;M3HO6;TE

I8Ny 37ASMA 6E77

ANTI:ODIES

A6TIVATED MA6RO3HAGES

RENA7 :7OOD VESSE7S

cell mediated hypersensitivity #(


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